Amoxiclav Quicktab

Mu kapangidwe mapiritsi 250 mg / 125 mg yogwira pophika amoxicillin (mawonekedwe a trihydrate) ndi clavulanic acid (potaziyamu mchere). Mapiritsiwo amakhalanso ndi zigawo zothandiza: MCC sodium croscarmellose.

Mapiritsi a Amoxiclav 2X 625 mg ndi 1000 mg ili ndi zigawo zomwe zimagwira amoxicillin ndi clavulanic acid, komanso zina zowonjezera: anhydrous colloidal silicon dioxide, zonunkhira, machitidwe, oxide wachikasu chachitsulo, talc, mafuta a castrogen hydrate, MCC silrate.

Yopangidwa ndi mapiritsi Amoxiclav Quicktab 500 mg ndi 875 mg Muli yogwira pophika amoxicillin ndi clavulanic acid, komanso zina zowonjezera: anhydrous colloidal silicon dioxide, flavorings, aspartame, yellow iron oxide, talc, hydrogenated castor mafuta, MCC silicate.

Yopangidwa ndi ufa womwe kuyimitsidwa kwawakonzekere Amoxiclavmulinso amoxicillin ndi clavulanic acid, komanso ngati zinthu zopanda pake zimaphatikizanso sodium citrate, MCC, sodium benzoate, mannitol, sodium saccharin.

Yopangidwa ndi ufa pokonzekera kulowetsedwa Amoxiclav iv muli amoxicillin ndi clavulanic acid.

Kutulutsa Fomu

Mankhwalawa ali ngati mapiritsi. Amoxiclav 250 mg / 125 mg - mapiritsi okhala ndi mbali, phukusili lili ndi ma PC 15.

Amoxiclav 2X (500 mg / 125 mg, 875 mg / 125 mg) - mapiritsi, omwe amaphatikizidwa, amatha kukhala ndi 10 kapena 14 ma PC.

Amoxiclav Quicktab (500 mg / 125 mg, 875 mg / 125 mg) amapezeka mu mawonekedwe a mapiritsi omwazika, phukusi - mapiritsi 10 otere.

Komanso, chinthucho chimapangidwa ngati ufa kuchokera komwe kuyimitsidwa kumapangidwira; botolo limakhala ndi ufa wokonzekera 100 ml ya chinthucho.

Ufa umapangidwanso, momwe umapangidwira yankho, lomwe limayendetsedwa kudzera m'mitsempha. Botolo ili ndi 600 mg ya mankhwalawa (amoxicillin 500 mg, clavulanic acid 100 mg), mabotolo a 1.2 g amapezekanso (amoxicillin 1000 mg, clavulanic acid 200 mg), 5 fl.

Zotsatira za pharmacological

Kuzindikira kumapereka chidziwitso kuti mankhwala Amoxiclav (INN Amoksiklav) ndiwothandiza pazowonera zambiri. Gulu la antibiotic: penicillin yotakata. Kuphatikizidwa kwa mankhwalawa kuli amoxicillin (penicillin semi-synthetic) ndi clavulanic acid (β-lactamase inhibitor). Kupezeka kwa clavulanic acid pakukonzekera kumatsimikizira kukana kwa amoxicillin machitidwe a β-lactamases, omwe amapangidwa ndi tizilombo.

Kapangidwe ka clavulanic acid ndi ofanana ndi mankhwala a beta-lactam, mankhwalawa amakhalanso ndi antibacterial. Amoxiclav ikugwira ntchito yolimbana ndi zovuta zomwe zimawonetsa kukhudzika kwa amoxicillin. Ichi ndi mzere mabakiteriya abwino, aerobic gram-negative bacteria, gram zabwino ndi gram alibe anaerobes.

Pharmacokinetics ndi pharmacodynamics

Malinga ndi kalozera wamankhwala a Vidal, pambuyo pakukonzekera pakamwa, zinthu zonse ziwiri zimaphatikizidwa kuchokera m'matumbo, kuyamwa kwa zinthuzo sikukhudzidwa ndi chakudya, choncho zilibe kanthu kuti muzidya bwanji musanadye kapena mutatha kudya. Oyang'anira ndende kwambiri magazi anati ola limodzi atamwa mankhwalawo. Zosakaniza zonse ziwiri za mankhwalawa zimagawidwa m'madzi ndi zimakhala. Amoxicillin amalowanso m'chiwindi, madzi amtunduwu, Prostate, ma cell, chikhodzodzo, minofu yamatenda, malovu, kubisala kwa bronchial.

Ngati ziwalo zaubongo sizipsa, zonse zomwe zimagwira sizimalowa mu BBB. Nthawi yomweyo, zigawo zikuluzikulu zimadutsa zotchinga, zovuta zawo zimatsimikiziridwa mkaka wa m'mawere. Amamangirira mapuloteni am magazi pang'ono.

Mthupi, amoxicillin amakhala ndi tsankho kagayidwe, clavulanic acid imapangidwa mwamphamvu kwambiri. Amachotsedwa m'thupi kudzera mu impso, tinthu tating'onoting'ono tomwe timatulutsa timatulutsa timimba ndi mapapu. Hafu ya moyo wa amoxicillin ndi clavulanic acid ndi maola 1-1,5.

Zowonetsa kugwiritsa ntchito Amoxiclav

Amoxiclav amalembera matenda opatsirana komanso otupa omwe amayamba chifukwa cha mphamvu ya tizilombo tomwe timayamwa mankhwalawa. Zizindikiro zotsatirazi zogwiritsira ntchito mankhwalawa zimatsimikiziridwa:

• matenda a ziwalo za ENT, komanso matenda opatsirana a chapamwamba kupuma thirakiti (otitis mediapharyngeal chotupa, sinusitis, pharyngitismatendawa)
• matenda amkodzo thirakiti ( cystitisat Prostate etc.)
• matenda a m'munsi kupuma thirakiti (chibayo, bronchitispachimake komanso chovuta)
• matenda azachidziwitso a matenda opatsirana,
• matenda a cholumikizira mafupa,
• matenda opatsirana a minofu yofewa, khungu (kuphatikizapo zotsatira zakuluma),
• matenda a m'mimba thirakiti (cholangitis, cholecystitis),
• matenda odontogenic.

Zomwe zimathandizanso Amoxiclav, muyenera kufunsa katswiri kuti mukambirane.

Contraindication

Kudziwa chifukwa chake mapiritsi ndi mitundu ina ya mankhwalawa amathandizira, munthu akuyenera kukumbukiranso zotsutsana zomwe zilipo kale:

• matenda mononucleosis,
• matenda am'mimba oyambitsidwa ndi chiwindi kapena cholestatic jaundice mukamamwa clavulanic acid kapena amoxicillin,
• lymphocytic leukemia,
• chidwi chachikulu ndi mankhwala opha maantibayotiki kuchokera pagulu la cephalosporins, penicillin, komanso mankhwala ena a beta-lactam,
• kukhudzika kwakukulu pazigawo zogwira ntchito za mankhwala.

Amalembedwa mosamala kwa anthu omwe ali ndi vuto la kuchepa kwa chiwindi, anthu omwe ali ndi matenda oopsa a impso.

Zotsatira zoyipa

Mukamamwa maantibayotiki, zotsatira zotsatirazi zitha kuoneka mwa odwala:

• Matumbo oyenda: kuwonongeka kulakalakakusanza, nseru, kutsegula m'mimba, kawirikawiri, kuwonetsa kupweteka kwam'mimba, kukanika kwa chiwindi ndikotheka, chiwonetsero chimodzi ndi hepatitis, jaundice, pseudomembranous colitis.
• Hematopoietic dongosolo: Nthawi zina, reukopenia, thrombocytopenia, kawirikawiri - eosinophilia, pancytopenia.
• Mawonetseredwe amatsutsa: kuyabwazotupa za erythematous urticaria, nthawi zina - anaphylactic manthakukokoloka kwachisoni, kutupa, Matupi a vasculitis, mawonetseredwe amodzi - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
• Machitidwe amachitidwe amanjenje: chizungulire, mutu, nthawi zina - kukomoka, kumva kuda nkhawa, kusowa tulo.
• Njira yamikodzo: khalid, interstitial nephritis.
• Nthawi zina, kukhala wamphamvu kwambiri kumachitika.

Amadziwika kuti chithandizo chotere, monga lamulo, sichimabweretsa mavuto.

Malangizo ogwiritsira ntchito Amoxiclav (Njira ndi Mlingo wa Amoxiclav kwa akuluakulu)

Mankhwala omwe amapezeka m'mapiritsi sakhazikitsidwa kwa ana osakwana zaka 12. Popereka mankhwala, muyenera kukumbukira kuti mlingo wovomerezeka patsiku la clavulanic acid ndi 600 mg (kwa akuluakulu) ndi 10 mg pa 1 kg ya kulemera kwa mwana. Mlingo wovomerezeka watsiku ndi tsiku wa amoxicillin ndi 6 ga kwa munthu wamkulu ndi 45 mg pa 1 kg yoleza mwana.

Kukonzekera kwa makolo kumakonzedwa ndikumatha kusungunula kwa vial m'madzi jekeseni. Kutha kwa 600 mg ya mankhwalawa, muyenera magawo 10 a madzi, kupasuka kwa 1.2 g ya mankhwalawa - 20 ml ya madzi. Njira yothetsera vutoli iyenera kuperekedwa pang'onopang'ono kwa mphindi 3-4. Kulowetsedwa kwamitseko kumayenera kupitilira kwa mphindi 30 mpaka 40. Osamayimitsa yankho.

Pamaso pa opaleshoni yoletsa kuphatikizira kwa purulent mavuto, muyenera kulowetsedwa kudzera mu mtsempha wa 1.2 g wa mankhwala. Ngati pali vuto la zovuta, mankhwalawa amaperekedwa kudzera pakhungu kapena pakamwa panthawi yomwe akuchitidwa opareshoni. Kutalika kwa kuvomerezedwa ndi adokotala.

Mapiritsi a Amoxiclav, malangizo ogwiritsira ntchito

Monga lamulo, achikulire ndi ana (omwe kulemera kwawo ndi woposa 40 makilogalamu) amalandira piritsi 1 lililonse maola asanu ndi atatu. (375 mg), bola ngati matendawa ndi ofatsa kapena ochepa. Njira inanso yovomerezeka pamilandu iyi ndi piritsi 1 lililonse maola 12. (500 mg + 125 mg). Kwa matenda opatsirana opatsirana, komanso matenda opatsirana am'mapapo, piritsi limodzi limawonetsedwa maola asanu ndi atatu aliwonse. (500 mg + 125 mg) kapena kudya piritsi lililonse la maola 12. (875 mg + 125 mg). Kutengera ndi matendawa, muyenera kumwa maantibayotiki masiku khumi ndi anayi, koma adotolo ayenera payekha kupereka mankhwala.

Kwa odwala omwe ali ndi matenda odontogenic, onetsani mankhwala maola 8 aliwonse, piritsi limodzi. (250 mg + 125 mg) kapena kamodzi kwa maola 12, piritsi limodzi lililonse. (500 mg + 125 mg) kwa masiku asanu.

Anthu okhala ndi malire kulephera kwa aimpsoPhwando la tebulo limodzi likuwonetsedwa. (500 mg + 125 mg) maola 12 aliwonse. Kulephera mwamphamvu kwaimpso ndi chifukwa chokulitsa nthawi yomwe yapezeka pakati Mlingo mpaka maola 24.

Kuyimitsidwa Amoxiclav, malangizo ntchito

M'badwo wa ana wodwalayo umapatsa kuwerengera kwa mlingo poganizira kulemera kwa mwana. Musanakonze madziwo, muyenera kugwedeza botolo bwino. Mlingo iwiri, 86 ml ya madzi uyenera kuwonjezeredwa m'botolo, nthawi iliyonse mukafuna kugwedeza zomwe zili mkati mwake bwino. Tiyenera kudziwa kuti supuni yoyesera imakhala ndi 5 ml ya malonda. Perekani mlingo kutengera zaka komanso kulemera kwa mwana.

Malangizo ogwiritsira ntchito Amoxiclav kwa ana

Kuyambira pobadwa mpaka miyezi itatu, ana amapatsidwa mankhwala pamlingo wa 30 mg pa 1 makilogalamu (patsiku), mankhwalawa amayenera kugawidwa mofananamo ndikuwathandizira nthawi zonse. Kuyambira wazaka zitatu, Amoxiclav amamuika pa 25 mg wa kulemera kwake pa kilogalamu imodzi, amafanizidwa chimodzimodzi. Mu matenda opatsirana olimba, mlingo umayikidwa pa 20 mg pa 1 makilogalamu kulemera kwake, umagawika pazigawo zitatu. Mu matenda opatsirana opatsirana, mlingo umayikidwa pa mlingo wa 45 mg pa 1 makilogalamu kulemera, ugawikane awiri Mlingo patsiku.

Mankhwala

Limagwirira ntchito Amoxiclav Quiktab ndi chifukwa cha kuphatikiza zigawo zina zomwe zimapangidwa:

• amoxicillin ndi anti-spectrum semisynthetotic antiotic womwe umagwira motsutsana ndi ma gram angapo opanda gram komanso opanda gramu, chifukwa chakuwonongeka kwake kwa chiwonongeko cha β-lactamases, chiwonetsero cha ntchito ya amoxicillin amangokhala pazinthu zazing'ono zomwe zimapanga enzyme iyi,
• clavulanic acid, β-lactamase inhibitor mogwirizana ndi penicillins, kupanga macephalosporins osiyanasiyana ndi penicillins omwe amalimbana ndi ma β lactamases omwe amapezeka kawirikawiri amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, timene timayambitsa kukana kwa mabakiteriya, koma timalephera motsutsana ndi chromosomal β mtundu. Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin ku chiwonongeko cha β-lactamases, kuilola kuti iwonjezeke mawonekedwe ake a antibacterial.

Amoxicillin osakanikirana ndi clavulanic acid amagwira ntchito motsutsana ndi microflora yotsatira ya pathogenic:

• Ma grorgan-aerobic tizilombo tating'onoting'ono: Streptococcus pneumoniae, Streptococcus viridans, Streptococcus pyogene, Enterococcus spp.
• Magram-negative aerobic tizilombo: Brucella spp., Bordetella pertussis, Campylobacter jejuni, Gardnerella vaginalis, Escherichia coli, Haemophilus ducreyi, Helicobacter pylori, Haemophilus spp. spp., Salmonella spp., Yersinia enterocolitica, Vibrio cholerae, Eikenella corrodens,
• Magram-zabwino anaerobic tizilombo: Actinomyces israelii, Peptostreptococcus spp., Peptococcus spp., Clostridium spp., Prevotella spp., Fusobacterium spp.,
• Ma grram-negative anaerobic tizilombo: Bacteroides spp.

Malangizo ogwiritsira ntchito Amoxiclav Quicktab: njira ndi mlingo

Mapiritsi a Amoxiclav Quiktab amatengedwa pakamwa, omwe kale amasungunuka mu 1 /₂ magalasi amadzi (osachepera 30 ml) ndikusakaniza bwino. Mutha kugwira piritsi pakamwa panu mpaka atasungunuka kwathunthu, kenako ndikukumeza.

Ndi bwino kumwa mankhwalawa musanadye chakudya kuti muchepetse zovuta zoyambira m'mimba.

Mlingo woyenera wa odwala ndi ana opitirira zaka 12 (okhala ndi kulemera kwa thupi woposa makilogalamu 40):

• Matenda ofatsa kapena ochepa: piritsi limodzi la Amoxiclav Quiktab 500 + 125 mg maola 12 aliwonse,
• woopsa wa matenda ndi kupuma thirakiti kuwonongeka: piritsi 1 la Amoxiclav Quicktab 875 + 125 mg maola 12 aliwonse kapena piritsi limodzi la Amoxiclav Quicktab 500 + 125 mg maola 8 aliwonse.

Kutalika kwa chithandizo mpaka milungu iwiri.

Ngati mankhwala adayamba ndi kholo la makulidwe a amoxicillin ndi clavulanic acid, ndiye kuti mukuyenera kusintha kuti mutenge mapiritsi a Amoxiclav Quiktab mkati.

Bongo

Zambiri pazotsatira zoyipa kapena kufa chifukwa cha mankhwala osokoneza bongo a Amoxiclav Quicktab sizinalembedwe.

Zizindikiro za bongo ndi kusokonezeka kwam'mimba: kupweteka kwam'mimba, kutsegula m'mimba / kusanza, kusowa tulo, kuda nkhawa, chizungulire ndizothekanso, munthawi zina - kukomoka mwamphamvu.

Chithandizo cha mankhwala chimayikidwa, mutatha kuchita kale magawo (ndi ma piritsi aposachedwa, osapitirira maola 4) kuti muchepetse kuyamwa kwa mankhwalawa - kugwedezeka kwam'mimba ndi kugwiritsa ntchito makala. Amoxicillin ndi clavulanic acid amachotsedwa pa hemodialysis. Wodwala amafunikira kuti ayang'anire kuchipatala.

Mukachepetsa kuthamanga kwa magazi, wodwalayo ayenera kutenga malo a Trendelenburg - atagona kumbuyo kwanu, kwezani pelvis molingana ndi mutu pakona pa 45 °.

Malangizo apadera

Munthawi ya mankhwala, kuwongolera ntchito ya chiwindi, impso ndi hematopoiesis kumafunika.

Mukuwonongeka kwambiri kwa aimpso, kusintha kosiyanasiyana kwa mankhwalawa kapena kuwonjezeka pakatikati pa Mlingo wake ndikofunikira.

Pochita mankhwala ndi Amoxiclav Quicktab, njira yonyenga imatheka chifukwa chogwiritsidwa ntchito ndi Benedict's reagent kapena Felling solution kuti mupeze kuchuluka kwa shuga mumkodzo, chifukwa chake, enzymatic reaction ndi glucosidase tikulimbikitsidwa.

Ndi mkhutu aimpso ntchito

Mlingo wa Amoxiclav Kviktab umasinthidwa m'njira yochepetsera mlingo kapena kukulitsa nthawi pakati pa Mlingo mogwirizana ndi kuopsa kwa kupezeka kwa impso:

• kulephera kwapakati mwamphamvu ndi creatinine chilolezo (CC) kuyambira 10 mpaka 30 ml / mphindi: piritsi 1 (500 + 125 mg) maola 12 aliwonse,
• kulephera kwambiri kwaimpso ndi CC zosakwana 10 ml / min: piritsi 1 (500 + 125 mg) maola 24 aliwonse.

Mu anuria, nthawi yapakati pakati Mlingo uyenera kuchuluka mpaka maola 48 kapena kuposerapo.

Chenjezo limalimbikitsidwa kwa odwala omwe ali ndi vuto laimpso pakumwa mankhwala.

Kuyanjana kwa mankhwala osokoneza bongo

• Maantacid, glucosamine, mankhwala ofewetsa tuvi tolimba, aminoglycosides: kuchepa mayamwidwe a Amoxiclav Quiktab,
• ascorbic acid: amachulukitsa kuyamwa kwa amoxicillin ndi clavulanic acid,
• diuretics, allopurinol, phenylbutazone, mankhwala osapinga a antiidal
• methotrexate: Amoxiclav Quicktab imathandizira poizoni wake,
• allopurinol: mankhwalawa amawonjezera zomwe zimachitika exanthema,
• disulfiram: pewani mgwirizano ndi Amoxiclav Quiktab,
• Mankhwala a anticoagulant: popeza Amoxiclav Quiktab nthawi zina amatha kutalikitsanso nthawi ya prothrombin, kusamala kuyenera kugwiritsidwa ntchito nthawi yomweyo.
• rifampicin: Ndiwotsutsana wa amoxicillin wokhala ndi kufooka kwa antibacterial ogwira,
• mankhwala opatsirana a bacteriostatic (macrolides, tetracyclines), sulfonamides: Amoxiclav Quiktab ayenera kugwiritsidwa ntchito maola angapo asanatengedwe,
• phenenecid: linalake ndipo tikulephera kuphipha kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu,
• njira zakulera pakamwa: Amoxiclav Quicktab amachepetsa kugwira ntchito kwawo.

Anoxiclav Quiktab analogues akuphatikizapo Amoxivan, Amovicomb, Amoxicillin + Clavulanic acid, Amoxiclav, Arlet, Augmentin, Betaclav, Bactoclav, Verclav, Medoclav, Clamosar, Novaclav, Panclav 2X, Rapiclav, Ranklav, Flemoclav Soloktab, Dr.

Ndemanga za Amoxiclav Quiktab

Malinga ndi ndemanga, Amoxiclav Quicktab ndi mankhwala othandizira omwe amathandizira matenda osiyanasiyana. Odwala ambiri amakonda kukoma kwa mapiritsi osungunuka ndipo owerengeka okha amawatcha osasangalatsa. Kutheka kugwiritsa ntchito mankhwalawa panthawi yapakati komanso panthawi yoyamwitsa kumadziwika kuti ndi mwayi wabwino. Kutsimikizika kwapadera pakuwunika kumaperekedwa pakufunika kotsatira malangizo azachipatala akamamwa mapiritsi.

Ambiri mwa odwala nthawi zambiri amaganiza kuti mtengo wa mankhwalawo ndiye mtengo waukulu womwe ungabwezere.

Mapiritsi a Amoxiclav ndi ufa - malangizo ogwiritsira ntchito

Kwa ana ochepera zaka 12 - 40 mg pa kilogalamu ya kulemera kwa tsiku.
Kwa ana omwe kulemera kwawo kupitilira 40 makilogalamu, mankhwalawa amamulembera ngati munthu wamkulu.

Akuluakulu amalembedwa: Mapiritsi 375 mg amatengedwa tsiku lililonse la 8 tsiku lililonse, mapiritsi a 625 mg maola 12 aliwonse. Popereka mankhwala othandizira odwala kwambiri, Mlingo wa 625 mg maola 8 aliwonse, kapena 1000 mg maola 12 aliwonse, amagwiritsidwa ntchito.

Tiyenera kudziwa kuti mapiritsi amatha kusiyanasiyana malinga ndi zomwe zimagwira. Chifukwa chake, simungathe kusintha piritsi la 625 mg (500 g ya amoxicillin ndi 125 g ya clavulanic acid) ndi mapiritsi awiri 375 mg (250 g of amoxicillin ndi 125 g ya clavulanic acid).

Dongosolo lotsatirali limagwiritsidwa ntchito pochiza matenda a odontogenic. Mapiritsi 375 mg amatengedwa maola 8 aliwonse, pozungulira wotchi. Mapiritsi a 625 mg pambuyo pa maola 12.

Ngati ndi kotheka, kugwiritsa ntchito mankhwala pochiza odwala omwe ali ndi matenda a impso ayenera kuganizira zomwe zili mu mkodzo waine. Odwala omwe ali ndi matenda a chiwindi amafunikira kuwunika ntchito yawo nthawi zonse.

Mphamvu yakuyimitsidwa kwa makanda ndi ana mpaka miyezi itatu. Dosing imachitika pogwiritsa ntchito kapeniki woyezera wapadera kapena supuni. Mlingo - 30 mg ya amoxicillin pa kilogalamu ya kulemera, kawiri pa tsiku.

Kwa ana okulirapo kuposa miyezi itatu kwa matenda ofatsa komanso odziletsa - 20 mg / kg yolemetsa thupi, komanso matenda oopsa - 40 mg / kg. Mlingo wachiwiri umagwiritsidwanso ntchito pochizira matenda oopsa - kutupa kwa khutu lapakati, sinusitis, bronchitis, chibayo. Malangizo amaphatikizidwa ndi mankhwalawa, momwe mumakhala matebulo apadera omwe amakupatsirani kuti muwerenge molondola kuchuluka kwa mankhwalawa kwa ana.

Mlingo wovomerezeka wa ana tsiku lililonse ndi ana ndi 45 mg / kg, kwa akulu - 6 magalamu. Clavulanic acid imatha kutengedwa patsiku osaposa 600 mg kwa akulu ndi 10 mg / kg kwa ana.

Mlingo

Mapiritsi okhala ndi mafilimu 500 mg / 125 mg, 875 mg / 125 mg

Piritsi imodzi yokutidwa ndi kanema ili

ntchito: amoxicillin (monga amoxicillin trihydrate) 500 mg ndi clavulanic acid (monga potaziyamu clavulanate) 125 mg (kwa 500 mg / 125 mg) kapena amoxicillin (monga amoxicillin trihydrate) 875 mg ndi clavulanic acid (monga potaziyamu clavulanate) 125 mg (Mlingo wa 875 mg / 125 mg).

zokopa: colloidal silicon dioxide, crospovidone anhydrous, sodium carboxymethyl cellulose, magnesium stearate, ya cellulose yophimba ya microcrystalline.

filimu co kuyanika: hydroxypropyl cellulose, ethyl cellulose, polysorbate, triethyl citrate, titanium dioxide (E 171), talc.

Mapiritsiwa adakutidwa ndi utoto wa filimu yoyera kapena yoyera, oblong, yokhala ndi bevel, wolembedwa "875/125" ndi chikhomo mbali imodzi, ndipo adalemba ndi "AMS" mbali inayo (pamtundu wa 875 mg / 125 mg).

Fgulu laacacotherapeutic

Mankhwala a antibacterial pakugwiritsa ntchito kwadongosolo. Beta-lactam antibacterial mankhwala - Penicillins. Ma penicillin osakanikirana ndi beta-lactamase zoletsa. Clavulanic acid + amoxicillin.

ATX Code J01CR02

Mankhwala

Pharmacokinetics

Amoxicillin ndi clavulanic acid amasungunuka kwathunthu mu madzi amchere pazofunikira za thupi pH. Zonsezi ndizoyamwa bwino pakamwa. Mulingo woyenera kumwa amoxicillin / clavulanic acid mukadzayamba kudya. Pambuyo pakamwa, bioavailability wa amoxicillin ndi clavulanic acid pafupifupi 70%. Mphamvu ya kuchuluka kwa mankhwalawa mu plasma ya zigawo zonse ziwiri ndi zofanana. Pazambiri za seramu ndizodziwikiratu zimafikira ola limodzi pambuyo pa kukhazikitsa.

Serum imags ya amoxicillin ndi clavulanic acid akamatenga kuphatikiza kwa amoxicillin / clavulanic acid akukonzekera ali ofanana ndi omwe amawerengedwa pakamwa pokhapokha ngati gawo limodzi la amoxicillin ndi clavulanic acid.

Pafupifupi 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin amamangiriza mapuloteni a plasma. Kuchuluka kwa magawa pakamwa pakumwa mankhwala pafupifupi 0.3-0.4 l / kg wa amoxicillin ndi 0,2 l / kg wa clavulanic acid.

Pambuyo pokonzanso mtsempha wamagazi, onse amoxicillin ndi clavulanic acid adapezeka mu chikhodzodzo, mafinya am'mimbamo, khungu, mafuta, minofu yamatumbo, zotumphukira ndi zotumphukira, bile ndi mafinya. Amoxicillin amalowa bwino mu madzi a cerebrospinal.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga. Zinthu zonsezi zimadutsanso mkaka wa m'mawere.

Amoxicillin amachotsekedwa pang'ono mu mkodzo wofanana ndi penicillic acid wofanana ndi 10-25% ya mlingo woyamba. Clavulanic acid imapangidwa m'thupi ndi kuponyera mkodzo ndi ndowe, komanso mpweya wa mpweya wothira mpweya.

Kuchulukitsa kwapakati theka la moyo wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi, ndipo kuvomerezeka kokwanira pafupifupi 25 l / h. Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo mkati mwa maola 6 atatha kumwa kamodzi pa mapiritsi a amoxicillin / clavulanic acid. Pa maphunziro osiyanasiyana, zidapezeka kuti 50-85% ya amoxicillin ndi 27-60% ya clavulanic acid amachotsedwa mkodzo mkati mwa maola 24. Kuchuluka kwacrosulanic acid kumachotsedwa pakatha maola 2 mutatha ntchito.

Kugwiritsa ntchito pamodzi kwa phenenecid kumachepetsa kutulutsidwa kwa amoxicillin, koma mankhwalawa samakhudza kutuluka kwa clavulanic acid kudzera mu impso.

Hafu ya moyo wa amoxicillin imakhala yofanana mwa ana a zaka zitatu mpaka ziwiri, komanso mwa ana achikulire ndi akulu. Popereka mankhwala kwa ana aang'ono kwambiri (kuphatikiza ana akhanda) m'milungu yoyamba ya moyo, mankhwalawa sayenera kuperekedwa kawiri patsiku, omwe amalumikizidwa ndi kusakhazikika kwa njira ya impso kwa ana. Chifukwa chakuti odwala okalamba amatha kuvutika ndi vuto la impso, Amoxiclav 2X iyenera kugwiritsidwa ntchito mosamala m'gululi la odwala, koma ntchito yaimpso iyenera kuyang'aniridwa ngati kuli koyenera.

Chilolezo chonse cha amoxicillin / clavulanic acid m'madzi am'magazi amachepetsa mwachindunji kuchepa kwa impso. Kuchepa kwa chilolezo cha amoxicillin kumanenedweratu poyerekeza ndi clavulanic acid, chifukwa kuchuluka kwa amoxicillin kumathandizidwa kudzera mu impso. Chifukwa chake, popereka mankhwala kwa odwala omwe amalephera aimpso, kusintha kwa mankhwalawa ndikofunikira kuti muchepetse kuchuluka kwa amoxicillin ndikukhalabe wofunikira clavulanic acid.

Popereka mankhwala kwa odwala omwe ali ndi vuto la chiwindi, muyenera kusamala posankha mlingo ndikuwonetsetsa ntchito ya chiwindi.

Mankhwala

Amoxicillin ndi mankhwala opanga ma cell kuchokera ku penicillin gulu (beta-lactam antiotic) lomwe limalepheretsa ma enzyme amodzi kapena angapo (omwe nthawi zambiri amatchedwa ma penicillin-binding protein) omwe amaphatikizidwa ndi biosynthesis ya peptidoglycan, yomwe ndi gawo lofunikira kwambiri mwa khoma la bakiteriya. Kuletsa kwa peptidoglycan synthesis kumayambitsa kufooka kwa khungu la cell, nthawi zambiri kumatsatiridwa ndi lysis l cell ndi cell cell.

Amoxicillin amawonongeka ndi beta-lactamases opangidwa ndi mabakiteriya osagwira, chifukwa chake zochitika za amoxicillin zokhazokha sizimaphatikizapo tizilombo tating'onoting'ono timene timatulutsa ma enzymes amenewa.

Clavulanic acid ndi beta-lactam mwapangidwe kogwirizana ndi penicillin. Imalepheretsa ma beta-lactamase, potero kuletsa kuyamwa kwa amoxicillin, ndikukulitsa zochitika zake. Clavulanic acid yokha ilibe mphamvu yokhudza antibacterial.

Kuchulukitsa nthawi yopitilira muyeso wosachepera (T> IPC) imawerengedwa kuti ndiyo yofunika kwambiri pakuwonetsa mphamvu ya amoxicillin.

Njira ziwiri zomwe zingalimbane ndi amoxicillin ndi clavulanic acid ndi:

inactivation ndi bacteria beta-lactamases omwe saponderezedwa ndi clavulanic acid, kuphatikiza makalasi B, C ndi D.

kusintha kwa mapuloteni omangira penicillin, omwe amachepetsa kuyanjana kwa antibacterial wothandizila ku pathogen yomwe akufuna.

Kusakhudzidwa kwa mabakiteriya kapena njira ya pampu ya efflux (kayendedwe ka zinthu) kumatha kuyambitsa kapena kupitiliza kulimbana ndi mabakiteriya, makamaka mabakiteriya osavomerezeka.

Miyezo yokhazikika ya MIC ya amoxicillin / clavulanic acid ndizomwe zimatsimikiziridwa ndi Komiti Yaku Europe Yoyesa Antimicrobial Sensitivity (EUCAST).

Mlingo wa mapiritsi a Amoxiclav kwa akuluakulu

Njira ndi Mlingo wa kugwiritsa ntchito Amoxiclav zimatsimikiziridwa ndi adotolo pamaziko a zinthu zambiri - kukonza, kuopsa kwa njira yotenga kachiromboka, kutulutsa kwake. Ndibwino kuchititsanso kuwunika kwawoko maubwino wa chithandizo cha mankhwala pogwiritsa ntchito maphunziro a bacteria.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Popeza mapiritsi osakanikirana a amoxicillin ndi clavulanic acid a 250 mg + 125 mg ndi 500 mg + 125 mg ali ndi kuchuluka komweko kwa clavulanic acid -125 mg, mapiritsi 2 a 250 mg + 125 mg siofanana ndi piritsi limodzi la 500 mg + 125 mg.

Zotsatira zoyipa

Kumwa mapiritsi a Amoxiclav kungayambitse kukulitsa zovuta zingapo:

• Dyspeptic syndrome - kusowa kwa chilakolako cha chakudya, nseru, kusanza kwakanthawi, kutsegula m'mimba.
• Mphamvu yamankhwala pakudya chamagaya oyambitsidwa ndi Amoxiclav imapangitsa khungu kuwonongeka kwa mano, kutupa kwa m'mimba mucosa (gastritis), kutupa kwamatumbo ang'onoang'ono (enteritis) ndi (colitis) yayikulu.
• Kuwonongeka kwa hepatocytes (maselo a chiwindi) ndi kuchuluka kwa michere yawo (AST, ALT) ndi bilirubin m'magazi, kuwonongeka kwa bile (cholestatic jaundice).
• Thupi lawo siligwirizana zomwe zimachitika kwa nthawi yoyamba ndipo zimatha kutsagana ndi matenda osiyanitsa - kuyambira pakhungu pakhungu mpaka pakukhazikika kwa anaphylactic.
• Kusokonezeka mu hematopoietic dongosolo - kuchepa kwa milingo ya leukocytes (leukocytopenia), maselo othandiza magazi kuundana (thrombocytopenia), kuchepa kwa magazi, magazi a hemolytic chifukwa cha kuwonongeka kwa maselo ofiira amwazi.
• Kusintha kwa magwiridwe antchito amtundu wamanjenje - chizungulire, kupweteka pamutu, kukulitsa khunyu.
• Kutupa kwamkati mwa impso (interstitial nephritis), mawonekedwe a makhiristo (crystalluria) kapena magazi (hematuria) mkodzo.
• Dysbacteriosis ndikuphwanya microflora wabwinobwino wa mucous membrane, chifukwa cha kuwonongeka kwa mabakiteriya omwe amakhala momwemo. Komanso, motsutsana ndi maziko a dysbiosis, vuto linalake lingakhale kukula kwa matenda oyamba ndi fungus.

Pankhani ya zovuta, kumwa mapiritsi a Amoxiclav kuyimitsidwa.

Gwiritsani ntchito panthawi yoyembekezera komanso poyamwitsa

Kafukufuku wazinyama sanawululire zowopsa za kumwa mankhwalawa panthawi yomwe ali ndi pakati komanso momwe zimakhudzira kukula kwa fetal.

Kafukufuku wina mwa azimayi omwe ali ndi matendawa asanakwane, zimapezeka kuti kugwiritsa ntchito prophylactic ndi amoxicillin / clavulanic acid kumatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mu akhanda. Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa amagwiritsidwa ntchito pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana. Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere. Mu makanda omwe amalandila yoyamwitsa, kukula kwa chidwi, kutsegula m'mimba, ma micidi a mucous nembanemba amkamwa amatha. Mukamamwa Amoxiclav 875 + 125, ndikofunikira kuthetsa nkhani yosiya kuyamwitsa.

Kufotokozera kwa mafomu omasulira

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi zoyera kapena zoyera. Mapiritsiwo ali ndi mawonekedwe owundana a biconvex.

Piritsi limodzi la 625 mg limakhala ndi 500 mg ya amoxicillin trihydrate ndi 125 mg ya clavulanic acid (mchere wa potaziyamu).

Mapiritsi amatha kupanga zitini zamapulasitiki (mapiritsi 15 aliyense) kapena matuza a aluminium a 5 kapena 7.

Mapiritsi a 1000 mg amaphatikizanso, amakhala ndi mawonekedwe osungika okhala ndi mbali zopindika. Pa iwo, mbali imodzi, zolemba za "AMS" zimayikidwa, mbali inayo - "875/125". Amaphatikizapo 875 mg ya antiotic ndi 125 mg ya clavulanic acid.

Kugwirizana kwina ndi mankhwala ena

• Ndiosafunika kugwiritsa ntchito nthawi yomweyo Amoxiclav ndi kukonzekera kwa anticoagulants. Izi zingayambitse kuchuluka kwa prothrombin nthawi.
• Kugwirizana kwa Amoxiclav ndi allopurinol kumayambitsa chiopsezo cha exanthema.
• Amoxiclav imawonjezera kawopsedwe wa metatrexate.
• Simungagwiritse ntchito onse amoxicillin ndi rifampicin - awa ndi osokoneza, ophatikizira ntchito amachepetsa mphamvu ya antibacterial onse.
• Amoxiclav sayenera kulembedwa pamodzi ndi tetracyclines kapena macrolides (awa ndi mankhwala opatsirana a bacteriostatic), komanso sulfonamides chifukwa chakuchepa kwa mphamvu ya mankhwalawa.
• Kutenga Amoxiclav kumachepetsa mphamvu zakulera m'mapiritsi.

Madokotala amafufuza

Anna Leonidovna, wothandizira, Vitebsk. Amoxiclav imakhala yothandiza kwambiri pochiza matenda osiyanasiyana opuma kuposa ake analogue, amoxicillin. Ndikupereka maphunzirowa masiku 5, kenako ndikofunikira kumwa mankhwala omwe amakonzanso microflora.

Veronika Pavlovna, dotolo. Mr. Kreshyi Rih. Mankhwalawa ali ndi zabwino kwambiri pamatenda oyambitsidwa ndi bakiteriya. Samakonda kuyambitsa mavuto, nthawi yomweyo ndimapereka mankhwala a antifungal, nditatha kumwa ma probiotic kuti ndikonzenso microflora yachilendo.

Andrei Evgenievich, dotolo wa ENT, Polotsk. Kugwiritsa ntchito mankhwalawa jekeseni kumakuthandizani kuti muchepetse kuwonetsa kwa matenda oopsa komanso olimbitsa a ziwalo za ENT. Mankhwala amathandizira kutukusira khutu lapakati. Kuphatikiza apo, odwala amatenga bwino kuyimitsidwa kwa zipatso.

Ndemanga za Odwala

Victoria, Dnipropetrovsk. Kugwiritsidwa ntchito ndi adokotala pochiza matenda a tonsillitis. Anaona masiku 5. Mankhwala olimbana ndi mankhwalawa adayamba patsiku la 3 la matenda. Matendawa adachepetsa ndi wachitatu. Khosi langa linasiya kuwawa. Panali matenda otsegula m'mimba, ndinadutsa patangotha ​​masiku awiri, nditayamba kumwa mankhwala okonzanso kuti ndikonzenso microflora.

Alexandra, mzinda wa Lugansk. Mankhwalawa adalembedwa ndi dokotala kuti azichiza pyelonephritis. Maphunzirowa anali masiku 7. Jekeseni wa masiku atatu - kenaka mapiritsi. Jakisoni amakhala wowawa. Komabe, kusintha kunayamba mozungulira tsiku lachinayi. Panalibe mavuto. Ndiye kamwa youma ija.

Tamara, mzinda wa Boyarka. Adandilowetsa mankhwalawa ngati mankhwalawa. Zimakhala zopweteka kwambiri, mikwingwirima idatsalira pamalo a jakisoni. Komabe, patatha sabata limodzi palibe chomwe chatsalira mu smears kuchokera kwa pathogen.

Malangizo ogwiritsira ntchito Amoxiclav Quicktab

Asanatenge, piritsi liyenera kusungunuka mu 100 ml ya madzi (kuchuluka kwa madzi kungakhale kambiri). Sanjani zomwe zili mkati musanagwiritse ntchito. Mukhozanso kutafuna piritsi, ndibwino kugwiritsa ntchito mankhwalawa musanadye. Akuluakulu ndi ana atafika zaka 12 ayenera kumwa piritsi limodzi patsiku. 625 mg katatu patsiku. M'matenda opatsirana opweteka, piritsi 1 ndi mankhwala. 1000 mg 2 kawiri pa tsiku. Kuchiza sikuyenera kupitilira milungu iwiri.

Nthawi zina adotolo atha kufotokozera fanizo la mankhwalawa, mwachitsanzo, Flemoklav Solutab ndi ena.

Amoxiclav ndi angina

Mankhwala a Amoxiclav zilonda zapakhosi wamkulu ndi piritsi 1. 325 mg kamodzi pa maola 8 aliwonse. Njira inanso yoyenera imaphatikizira kumwa piritsi limodzi kamodzi pa maola 12 aliwonse. Dokotala atha kukulemberani mankhwala apamwamba ngati matendawo ali akulu. Chithandizo cha angina mu ana zimaphatikizapo kugwiritsa ntchito kuyimitsidwa. Monga lamulo, supuni 1 imayikidwa (supuni ya kumwa ndi 5 ml). Pafupipafupi kuvomerezedwa ndi adokotala, zomwe ndizofunika kutsatira. Momwe kumwa Amoxiclav mu ana angina zimatengera kuopsa kwa matendawa.

Mlingo wa Amoxiclav wa sinusitis

Kodi Amoxiclav amathandizira ndi sinusitis, zimatengera zomwe zimayambitsa matendawa. Mlingo watsimikiza ndi otolaryngologist. Ndikulimbikitsidwa kuti mumwe mapiritsi 500 mg katatu patsiku. Masiku angati kumwa mankhwalawa zimatengera kuopsa kwa matendawa. Koma zizindikiro zikatha, muyenera kumwa mankhwalawo masiku ena awiri.

Kuchita

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala enaake ndi mankhwala ena, mawonekedwe osafunikira amatha kuchitika, chifukwa chake mapiritsi, madzi osokoneza bongo komanso osakanikirana sayenera kugwiritsidwa ntchito limodzi ndi mitundu ingapo ya mankhwala.

Kugwiritsa ntchito pamodzi mankhwala Glucosamine, maantacid, aminoglycosides, mankhwala ofewetsa nkhawa amachepetsa kuyamwa kwa Amoxiclav, mukamamwa pamodzi Ascorbic acid - mayamwidwe kwachitika mofulumira.

Ndi mankhwala omwewa pamodzi ndi phenylbutazone, okodzetsa, NSAIDs, Allopurinol ndi mankhwala ena omwe amatseka katulutsidwe ka tubular, kuwonjezeka kwa kuchuluka kwa amoxicillin kumachitika.

Ngati munthawi yomweyo makonzedwe a anticoagulants ndi Amoxiclav amachitidwa, nthawi ya prothrombin imawonjezeka. Chifukwa chake, ndikofunikira kupereka ndalama mosakanikirana mosamala.

Amoxiclav imawonjezera kawopsedwe Methotrexate mukutenga.

Mukamamwa Amoxiclav ndipo Allopurinol mwayi wowonetsera wa exanthema ukuwonjezeka.

Sayenera kumwedwa nthawi yomweyo Disulfiramndi Amoxiclav.

Otsutsa ogwirizana ndi amoxicillin ndipo Rifampicin. Mankhwala onse amachepetsa mphamvu ya antibacterial.

Amoxiclav ndi bacteriostatic antibacterial (tetracyclines, macrolides), komanso sulfonamides sayenera kumwa nthawi yomweyo, chifukwa mankhwalawa amatha kuchepetsa mphamvu ya Amoxiclav.

Khalid kumawonjezera ndende ya amoxicillin ndikuchepetsa mayeso ake.

Mukamagwiritsa ntchito Amoxiclav, mphamvu ya zotsatirapo za kulera kwapakamwa imatha kuchepa.

Zowonjezera

Ngati mankhwalawa amagwiritsidwa ntchito kwanthawi yayitali, ndikofunikira kuyang'anira ntchito ya chiwindi, ziwalo zopanga magazi ndi impso za wodwalayo. Ngati wodwalayo wasokoneza ntchito yaimpso, ndikofunikira kusintha mlingo kapena kuonjezera pakadali pakati Mlingo wa mankhwala. Ndikwabwino kumwa mankhwala ndi chakudya. Pankhani ya superinfection (mawonekedwe a microflora osazindikira maantibayotiki), ndikofunikira kusintha mankhwalawa. Chifukwa chakuchulukana kwa matupi a cephalosporins mwa odwala omwe ali ndi penicillin, sikofunikira kugwiritsa ntchito maantibayotiki nthawi imodzi.

Mukamamwa mankhwalawa, muyenera kumwa madzi ambiri kuti mupewe mapangidwe amkodzo wa amoxicillin.

Mukuyenera kudziwa kuti kupezeka kwa Mlingo wambiri wa maantibayotiki mthupi kumatha kupangitsa kuti shuga azigwirizana ndi mkodzo (ngati njira ya Benedict kapena yankho la Fleming imagwiritsidwa ntchito kuti adziwe). Zotsatira zodalirika pamenepa zimapereka ntchito ya enzymatic reaction ndi glucosidase.

Popeza zotsatira zoyipa za m'magazi amanjenje ndizotheka kugwiritsa ntchito mankhwalawa, ndikofunikira kuyendetsa bwino magalimoto (magalimoto) kapena kuchita zinthu zomwe zimafunikira chidwi, kuthamanga ndi chidwi.

Amamasulidwa pa mankhwala.

Kutulutsa Mafomu

Pakalipano, wopanga mankhwalawa amapanga mitundu iyi:

• mu mapiritsi okhala ndi filimu
• mu mawonekedwe a ufa, cholinga chake chachikulu ndikupanga kuyimitsidwa,
• mu mawonekedwe a lyophilized ufa, womwe umapangira jekeseni wamkati.

Dziwani kuti musanagwiritse ntchito mankhwalawa ngati ufa, ayenera kuchepetsedwa m'madzi apadera - njira yothetsera. Kapenanso mutha kugwiritsa ntchito madzi omveka. Mitundu yonse ya Mlingo wa wothandizirayo tikambirana kwambiri.

Amoxiclav mu mawonekedwe a mapiritsi ali ndi ndende yosiyanasiyana yogwira zinthu. Amaperekedwa m'makanema amitundu itatu:

Kuphatikiza apo, mapiritsi a Amoxiclav pali zina zowonjezera zomwe zimapereka mapangidwe a mamasukidwe a mankhwala. Izi zikuphatikiza ndi magnesium stearate, silicon dioxide, komanso cellulose ndi citric acid. Mankhwala Amoxiclav mu mawonekedwe a mapiritsi musanayambe kugwiritsidwa ntchito amalimbikitsidwa kuti asungunuke m'madzi mu 100 ml. Ngati sizotheka kuchita izi, ndiye kuti muyenera kutafuna piritsi, kenako kumwa mankhwalawo ndi madzi okwanira.

Amoxiclav mu mawonekedwe a ufa wopangidwira kukonzekera kuyimitsidwa amatengedwa pakamwa. Imapezeka m'mitundu itatu:

• Amoxiclav 125. Kuphatikiza pa chinthu chachikulu yogwira amoxicillin, chomwe chili ndi 75 mg pakukonzekera kumeneku, kumakhala ndi mchere wa clavulanic acid wambiri 31.25 mg, woperekedwa mwa mawonekedwe a trihydrate,
• Amoxiclav 250. Zomwe zimapangidwira ufa zimakhala ndi 250 mg ya antiotic komanso kuwonjezera mchere wamchere mu 62,5 mg,
• Amoxiclav 400. Muli 400 mg ya amoxicillin ndi clavulanic acid mu 57 mg.

Monga zowonjezera zina, chingamu, sodium saccharase, silicon dioxide, ndi citric acid zilipo pakuyimitsidwa.

Pokonzekera kuyimitsidwa, malangizo ogwiritsa ntchito amatsatiridwa. Ufa umasungunuka m'madzi oyenera. Botolo loti lisungunuke kwathunthu pazigawo limagwedezeka mwamphamvu.

Ufa wothandizira kuti mtsempha wa magazi aziyamwa. Wopanga amapanga mitundu iwiri:

• Amoxiclav 500. Zomwe zili muzinthu zazikulu zomwe zimagwira ntchito ndi 500 mg. Amawonetsedwa ngati mchere wa sodium. Kuphatikiza apo, mchere wa clavulanic acid mu mawonekedwe a mchere wa potaziyamu wa 100 mg ulipo.
• Amoxiclav 1000. Muli amoxicillin mu kuchuluka kwa 1000 mg ndi 200 mg ya acid.

Kwa jekeseni wamkati, kuyimitsidwa kumachitika ndi kupukuta ufa wowuma ndi madzi omwe amalowetsedwa kulowetsedwa. Mankhwala omalizidwa amapaka jekete kapena ndi dontho. Mankhwala akaperekedwa ndi njira ya ndege, amayesa kuyiyendetsa mu mtsempha pang'onopang'ono momwe mungathere. Izi zimathandizira kukwaniritsa mwachangu kwa njira yothandizira odwala, komanso zimathandizira kukonza mkhalidwe wa wodwalayo. Ngati pakufunika kachitidwe ka mankhwala kwa nthawi yayitali, ndiye kuti kulowetsedwa kwa mankhwalawa kumachitika kudzera mu mtsempha.

Mankhwalawa ali ndi ma analogu ena omwe amalepheretsa ngati pakhale kuti palibe mu mankhwala:

Mankhwala, mtengo wa Amoxiclav ufa umakhala pafupifupi 120 r. Mtengo wamapiritsi umatengera kuchuluka kwa zinthu zomwe zimagwira, komanso mawonekedwe a kumasulidwa. Pafupifupi, mtengo wamankhwala amtunduwu wamankhwala umasiyana 230 mpaka 450 p. pa paketi iliyonse.

Malangizo ogwiritsira Amoxiclav mu piritsi

Zochizira odwala ochepa azaka zopitilira 12 ndi thupi lolemera kuposa 40 kg, komanso achikulire, Amoxiclav 250 mg nthawi zambiri amakhazikitsidwa. Wodwala amatenga piritsi limodzi masana maola 8 aliwonse. Pa mankhwala ndi Amoxiclav 500 mg, mlingo wa mankhwalawa ndi katatu patsiku, piritsi limodzi. Kwa akulu omwe akulimbana ndi matenda oopsa, Amoxiclav 1000 mg ndi mankhwala. Wodwala ayenera kumwa piritsi limodzi kawiri pa tsiku. Kutalika kwa mankhwala ndi mankhwalawa piritsi kumasiyana masiku 5 mpaka 14. Ngati maantibayotiki agwiritsidwa ntchito kwanthawi yayitali, ndiye kuti mungakhumudwenso.

Musanagwiritse ntchito piritsi la Amoxiclav, ndikofunikira kuti muyiyeretsa ndi theka kapu yamadzi. Zomwe zikuchokera zimayenera kusakanikirana. Pambuyo pokhapokha izi, izi zikuyenera kuledzera. Ngati palibe madzi pafupi, ndiye kuti piritsi liyenera kutafunidwa mosamala musanameze, kenako ndikusambitsidwa ndi madzi ambiri.

Malangizo ogwiritsira ntchito Amoxiclav mu mawonekedwe a kuyimitsidwa

Zochizira matenda omwe adadza mwa ana, Amoxiclav mu mawonekedwe a kuyimitsidwa amagwiritsidwa ntchito makamaka. Popereka mankhwala kwa ana akhanda ndi akhanda kuyambira zaka zitatu, mlingo uyenera kusankhidwa mosamala pakukhazikitsa mankhwalawa. Pofuna kutsogolera mlingo wa mankhwalawa panthawi ya mankhwala, supuni yoyezera imapezeka phukusi ndi mankhwalawo.

Kwa ana okulirapo, mulingo chigono chimodzi. Mu malangizo omwe aphatikizidwa ndi mankhwalawa, mutha kupeza piritsi lapadera lomwe mutha kuwerengera moyenera mankhwalawa kwa mwana, kutengera kulemera kwake komanso msinkhu wake.

Kugwiritsa ntchito bwino, mankhwalawa amayenera kumwedwa kawiri pa tsiku maola 12 aliwonse. Kapena mankhwalawa amatha kutha pambuyo pa maola 8 katatu patsiku. Dokotala amatha kudziwa kuchuluka kwa mankhwalawo, komanso kusankha mtundu woyenera wa mankhwalawo. Simuyenera kudzipangira nokha mankhwalawa, chifukwa kumwa mankhwalawo mosayenera kungayambitse matenda bongo. Ndipo izi zimakhala ndi zotsatirapo zoipa zaumoyo.

Mankhwala a Amoxiclav pa nthawi yapakati

Ndi osafunika kupereka Amoxiclav pa nthawi yochizira zochizira matenda opatsirana. Chowonadi ndi chakuti zinthu zomwe zimapezeka pakupanga mankhwalawa zimatha kulowa m'chiberekero cha fetus popanda zovuta zilizonse, komanso, kupukusidwa mkaka wa m'mawere.

Mbali iyi ya mankhwalawa imatha kupangitsa kuti kugwiritsa ntchito mankhwala oyembekezera kukhudza thanzi la mwana.

Zochizira amayi apakati, mankhwalawa amagwiritsidwa ntchito molingana ndi mawonekedwe. Pa mankhwala, amachita mogwirizana ndi malangizo. Amalandira kwa amayi omwe ali ndi "mwayi wosangalatsa" pokhapokha ngati mankhwalawo atha kukhala ochuluka kuposa chiwopsezo chomwe chingaberekedwe kwa mwana wosabadwayo. Chifukwa chakuti pawiri yogwira mankhwalawa imalowa mosavuta mkaka wa m'mawere, nthawi ya mkaka wa m'mawere, ngati pakufunika chithandizo, kuyamwitsa kumayimitsidwa ndikudyetsedwa pazosakaniza zochita kupanga.

Zotsatira zoyipa

Madokotala akasankha mankhwala monga Amoxiclav pochiza matenda, wodwalayo amatha kupeza zotsatirazi:

• Kuperewera kwa chakudya, nseru. Kuphatikiza apo, Zizindikiro zomwe zimayambitsa matenda monga colitis, gastritis, ndi khungu la enamel ya mano zimatha kuchitika. Kuwonongeka kwa chiwindi kumatsimikiziridwa mu milandu yayikulu. Kusintha kwa kuchuluka kwa magazi kumatha kuonekeranso, zizindikiro zokhudzana ndi kuchepa kwa chiwindi, chiwindi chimatha. Ndikofunika kudziwa kuti zoyipa zimakonda kupezeka kwa odwala atakalamba.
• Mutu, chizungulire komanso kusowa tulo. Hyperacaction kapena kusachita bwino kwa wodwala yemwe akutenga Amoxiclav zitha kuwonekeranso. Matenda okomoka amatha kuchitika kwa odwala omwe ali ndi matenda a impso ngati Amoxiclav atengedwa waukulu.
• thrombocytopenia, thrombocytosis,
• kuyabwa, kuwoneka kwa poizoni wa epidermal necrolysis.

Amoxiclav imatengedwa nthawi yayitali, ndizotheka chiopsezo cha malungo.

Ndikofunika kudziwa kuti zomwe zimatchulidwa pamwambapa zimachitika pakumwa mankhwalawa kapena mukangomaliza chithandizo. Zochitika zonse zosasangalatsa zimasinthidwa, komabe, kuwonongeka kwa chiwindi kungakhale kwambiri. Amapezeka makamaka mwa odwala omwe ali ndi chiwindi, kapena amayamba chifukwa cha kumwa mankhwala a hepatoxic.

Pomaliza

Amoxiclav ndi mankhwala omwe ali m'gulu la mankhwala a penicillin. Itha kugwiritsidwa ntchito pochiza matenda osiyanasiyana. Mankhwalawa ali ndi mphamvu yothandizira antibacterial, yomwe imakuthandizani kuti muchotse wodwala matenda omwe abwera. Chida ichi chimapezeka m'mafakitale osiyanasiyana.

Amamasulidwa mu mawonekedwe a mapiritsi, ufa. Kuchiza matenda kumachitika mwa ana ndi akulu. Mwachilengedwe, kuchuluka kwa mankhwalawa kwa mitundu iyi ya odwala kumasiyana. Pa nthawi yoyembekezera, mankhwalawa ali osavomerezeka. Izi zimaphatikizana, choyambirira, ndi chakuti zigawo zomwe zimapezeka mu mankhwalawa zimalowa mosavuta mu placenta ndi mkaka wa m'mawere. Chifukwa chake, tikulimbikitsidwa kuchiza matenda opatsirana panthawi yoyembekezera mothandizidwa ndi njira zina.

Panthawi yodyetsa, ndikofunikira kusiya kuyamwitsa ndikusamutsira chakudya ndi zosakaniza zopanga. Sitikulimbikitsidwa kudzipangira payekha chithandizo ndi Amoxiclav (mapiritsi), popeza kusankha kolakwika kwa mankhwalawa kungayambitse mavuto azaumoyo. Zikatero, ndikofunikira kutsuka m'mimba ndikuyamwa makala.

Analogi za Amoxiclav

Pali zitsanzo zingapo za mankhwalawa. Mtengo wa analogi zimatengera, choyambirira, pa wopanga mankhwalawo. Pali ma analogu ogulitsa otsika mtengo kuposa Amoxiclav. Kwa odwala omwe ali ndi chidwi chofuna kuthana ndi maantibayotiki, akatswiri amapereka mndandanda waukulu wa mankhwalawa. Izi zikutanthauza Moxiclav, Co-Amoxiclav, Augmentin, Clavocin, Flemoklav, Samalirani, Baktoklav, Ranklav, Amovicombndi ena Komabe, ndi dokotala yekha yemwe ayenera kupereka mankhwala othandizira. Mutha kusankha analogue yotsika mtengo pamapiritsi, mwachitsanzo, Augmentin. Muthanso kusankha analogue yaku Russia, mwachitsanzo, Amoxicillin.

Zomwe zili bwino: Amoxiclav kapena Augmentin?

Kodi Amoxiclav ndi Augmentin akupanga chiyani, pali kusiyana kotani pakati pa mankhwalawa? Zida zonsezi zili ndi zosakaniza zofanana, ndiye kuti, izi ndizofanana. Momwemo, zamankhwala zimapangitsa mankhwalawo kukhala ofanana, komanso mavuto ena. Opanga okha mankhwalawa ndiomwe amasiyana.

Amoxiclav pa mimba ndi mkaka wa m`mawere

Amoxiclav mimba itha kugwiritsidwa ntchito ngati zomwe zikuyembekezeredwa zikuchuluka kuposa zomwe zingavulaze fetus. Kugwiritsa ntchito Amoxiclav koyambirira kwa mimba ndikosayenera. 2 trimester ndi 3 trimester ndizofunikira kwambiri, koma ngakhale panthawiyi mlingo wa Amoxiclav pa nthawi yoyembekezera uyenera kuchitika mosamala kwambiri. Amoxiclav yoyamwitsa osapereka mankhwala, popeza magawo a mankhwala amalowerera mkaka wa m'mawere.

Ndemanga za Amoxiclav

Mukukambirana za Amoxiclav ya mankhwalawa, ndemanga za madokotala ndi odwala ndizabwino. Amadziwika kuti maantibayotiki amatha kuthandizira matenda opuma, ndipo ndioyenera kwa onse akuluakulu ndi ana. Ndemanga zimatchulapo mphamvu ya mankhwalawa a sinusitis, pa otitis media, matenda a kumaliseche. Monga lamulo, odwala achikulire amatenga mapiritsi a 875 mg + 125 mg, ndi mlingo woyenera, mpumulo wamatendawo umabwera msanga. M'mawunikidwe, zimadziwika kuti njira yothana ndi maantibayotiki, ndikofunika kumwa mankhwala omwe amayambiranso microflora.

Ndemanga za kuyimitsidwa kwa Amoxiclav ndizabwino. Makolo amalemba kuti ndibwino kupatsa ana zinthuzo chifukwa zimakoma kwambiri ndipo ana amazizindikira.

Mtengo wa Amoxiclav, komwe ungagule

Mtengo Mapiritsi a Amoxiclav 250 mg + 125 mg pafupifupi 200 ma ruble a 15 ma PC. Gulani maantibayotiki 500 mg + 125 mg ikhoza kukhala yamtengo wapatali pa 360 - 400 rubles kwa ma 15 pcs. Kodi mapiritsi ndi angati? 875 mg + 125 mgzimatengera malo ogulitsa. Pafupifupi, mtengo wawo ndi 420 - 470 rubles kwa 14 ma PC.

Mtengo Amoxiclav Quicktab 625 mg - kuchokera ku ma ruble 420 a ma PC 14.

Mtengo wa kuyimitsidwa Amoxiclav ya ana - 290 ma ruble (100 ml).

Mtengo Amoxiclav 1000 mg ku Ukraine (Kiev, Kharkov, etc.) - kuchokera ku 200 h scrollnias 14 zidutswa.