Pancreatic stool elastase

Pafupifupi kuyambira pobadwa, mu ndowe za munthu aliyense pali enzyme yapadera - pancreatic elastase. Izi sizokhazo zomwe zimapanga michere. Onsewa amagwira ntchito yawo ndikuchita zina muzogaya.

Pancreatic elastase ndi chizindikiritso cha pancreatic, zomwe akatswiri amazindikira momwe gland imayendera, kusintha kwamapangidwe ake parenchyma ndi mkhalidwe wazamoyo.

Gawo lalikulu la elastase mu madzi a pancreatic ndi pafupifupi 9%. Enzyme imalowa m'matumbo aang'ono, pomwe imayamba kuphwanya mapuloteni.

Ngati wodwala ali ndi matenda a kapamba kapena duodenum, ndiye kuti mlingo wa kapamba wam'mimba kwambiri umagwera pansi pazoyenera. Chifukwa chake, kutsimikiza kwa mulingo wake kumawerengedwa ngati chizindikiritso chodziwika bwino cha mitundu yosakwanira ya kapamba.

Enzyme iyi siyimasintha kapangidwe kake kapena kupangika kwake pakapita patsogolo kudzera m'matumbo am'mimba, chifukwa chake, zotsatira zomwe zimapezeka pofufuza ndowe zimawulula bwino chithunzi cha matenda omwe alipo.

Pancreatic elastase imagawika mitundu iwiri:

1. Mawonekedwe a pancreatic kapena elastase-1. Enzimuyi imapangidwa ndi ma cell a glandular cell ndipo imaperekedwa ku lumen ya m'mimba limodzi ndi zinthu zina za enzyme momwe zimapangira proelastase. Kenako, m'matumbo, mawonekedwe a enzyme awa amakonzedwa ndikusinthidwa kukhala elastase, yomwe imakhudzidwa ndikuwonongeka kwa mankhwala a protein. Elastase-1 ili ndi mawonekedwe enaake, kotero sizingatheke kuzimvetsa muzinthu zina kapena zomanga thupi. Gawo limatsimikizika ndi kuphunzira kwa ndowe.
2. Fomu la Serum kapena elastase-2. Utoto wambiri, motsutsana ndi zotupa zotupa kuchokera ku kapamba, umayenda mu kuwonongeka kwa maselo kulowa m'magazi. Wodwala akayamba kudwala matenda owopsa, ndiye kuti ma elastase-2 amapitilira zomwe amapezeka nthawi zambiri, zomwe zimatha kuwoneka pofufuza za labotale m'magazi a wodwalayo. Pambuyo patha maola 6 kuchokera pachiyambidwe cha pathological process, kuchuluka kwa seramu elastase kumayamba kuchuluka, kufikira pazofunikira kwambiri pambuyo pa maola 24-36. Hafu ya moyo wa michere iyi ndi yayitali kwambiri, motero, imatha kukhalabe m'magazi kwa masiku 5, kapenanso kupitirira sabata.

Ndi matenda am'mimba, kafukufuku wowerengera ndowe amawonedwa ngati njira imodzi yowunikira komanso yophunzitsira, chifukwa chake, kafukufuku wa kuchuluka kwa kapangidwe ka kapamba ka elastase akuwonetsedwa pakupangika kwa ma pathological process ngati:

• Kutupa kakhazikika kwa kapamba,
• Matenda a glandular osakwanira
• Cystic fibrosis,
• Gallstone matenda,
• Kuchedwa mu kukula kwa ana,
• Intraorganic chotupa mawonekedwe ndi njira,
• Thermal ileitis, matenda a Crohn,
• Zowonongeka zowopsa m'mapamba, etc.

Kukonzekera ndi kupita patsogolo

Kuti muphunzire kuchuluka kwa elastase mu ndowe, wodwala ayenera kukonzekera kaye.

• Ndikofunikira kusiya kumwa mankhwala omwe mwanjira iliyonse angakhudze zokhudzana ndi kapamba kapangidwe kazinsinsi ndi matumbo a m'mimba,
• Lekani kumwa mankhwala osokoneza bongo kapena mankhwala osokoneza bongo monga mafuta a castor ndi mafuta a parafini, mankhwala ofewetsa thukuta,
• Osamagwiritsa ntchito mafuta opangira kapena owonjezera pakugwiritsa ntchito rectal,
• Kanani kuseketsa ndi ma enema,
• Chepetsani kumwa kwa nyama zophatikizidwa ndi marinade, mafuta ndi okazinga.

Phunziro lofananalo silimalembedwa kwa odwala pakapita msambo, komanso pambuyo pa irrigoscopy ndi njira zina zodziwira pogwiritsa ntchito barium.

Ndikofunikira kusakaniza ndowe m'mawa mutatha kukodza komanso ukhondo wa kumatako komanso kumaliseche. Pambuyo pochulukitsa mu chida chapadera cha mankhwala, muyenera kutola ndowe ndi spatula yapadera.

Ndikofunikira kuti mudzaze zochuluka ndi gawo limodzi mwa magawo atatu, bukuli lidzakhala lokwanira kuphunzira kwathunthu. Malangizowo akuyenera kuphatikizidwa ndi chiwiya, pomwe dzina lonse, msinkhu wa wodwala, tsiku ndi zosonkhanitsa ndi nthawi zidzawonetsedwa.

Mukangolandira biomaterial, chidebecho chimayenera kupita ku labotale. Mwazowopsa, amaloledwa kusungira chidebecho mufiriji kwa madigiri 4-6 Celsius osaposa maola 5-8.

Mlingo wa pancreatic elastase mu ndowe

Mu ma labotale, akatswiri adzachita enzyme immunoassay, malinga ndi zotsatira zomwe dokotala athe kupeza bwino pazochitika za wodwala kapamba. Malinga ndi zomwe zapezeka, ndizotheka kuzindikira kukhalapo kwa njira za m'magazi kwa wodwalayo ndikuyamba kuzithetsa poyambira.

Chizindikiro chokhazikika cha pancreatic elastase imaganiziridwa kuti ndi 200 μg ya thunthu la enzyme pa gawo lililonse la muyeso.

Pozindikira m'munsimu, chizindikiritso chofunikira chidzafunika kuzindikiritsa zomwe zinapangitsa kuchepa kwa elastase-1. Pamitengo yotsika, zochitika za pancreatic sizothandiza.

Pa milingo ya pancreatic elastase ya 200-500 PIECES, ntchito yoyenera ya kapamba imapezeka, ndipo pamlingo wa 101-199 PIECES, kuchepa pang'ono kwa enzyme. Ngati mulingo wa elastase-1 ndi wotsika kuposa 101 PIECES, ndiye kuti wodwalayo ali ndi fomu yovuta ya pathological yovulala kwambiri pancreatic.

Kuti muzindikire zolondola, maphunziro owonjezera adzafunika.

Zomwe zimapangitsa kuchuluka ndi kuchepa kwa enzyme

Zambiri zimatha kuyambitsa kupatuka pamlingo wa elastase-1. Kuperewera kwodziwikiratu kwa enzyme kotereku kumayamba motsutsana ndi maziko azomwe zimachitika monga:

• Pancreatitis - chotupa cha kapamba makamaka chodwala,
• Cystic fibrosis - cholowa m'magazi chomwe chimakhudza magawo amthupi a thupi,
• Lactose tsankho,
• Njira za a Crohn,
• Hepatitis
• Pancreatic oncology,
• Mapangidwe a calculi mu bile ducts
• Matenda a shuga,
• Kutaya kwatsopano kwa kayendedwe kazinthu zamagetsi ndi zotumphukira zake pambuyo pake;
• Kuwonongeka kwa procrine parenchymal glandular minofu, etc.

Ndi kuwonjezeka kwakukulu kwa zizindikiro, pancreatic oncology, pancreatitis kapena gallstone matenda atha kupezekanso.

Mwachizolowezi, zikhalidwe za pathological izi zimaphatikizidwa ndi kupweteka m'matumbo ndi kapamba, kuchepa kwa thupi, kuchepa kwa magazi, kufooka, kutsekula m'mimba, kotero iwo sangayende.

Kusanthula kwamtengo

Mtengo wowerengera ndowe pazomwe zimapezeka pancreatic elastase kuzipatala zaku Moscow ndi ma ruble a 1705-2400.

Ma pathologies am'mimba amapezeka paliponse mwa odwala azaka zonse, popeza tonse timakumana ndi zovuta zoyipa zachilengedwe, chakudya chopanda thanzi, kupsinjika, etc.

Zinthu izi zimawononga thupi kwambiri, zimayambitsa zovuta zambiri komanso matenda. Ndipo mothandizidwa ndi njira zophunzitsira zodziwika bwino monga mayeso a chopondapo pamlingo wa pancreatic elastase, katswiri adzatha kufufuza moyenera komanso kupereka mankhwala othandiza.

Zambiri

Pancreas poyamba amapanga mawonekedwe osagwira a pancreatopeptidase E - proenastase proelastase, yomwe, monga gawo la pancreatic secretion, imalowa mu duodenum, pomwe imasinthidwa ndi trypsin kusinthika kwa elastase-1. Mosiyana ndi trypsin, enzyme iyi imakhala ndi ntchito yapamwamba: imalimbikitsa kukula kwa zomangira zovuta za peptide, mapuloteni elastin (gawo la minofu yolumikizana), ndi zina zambiri. Kuphatikiza poti thupi la munthu limabisa chinsinsi chake, amathanso kuchilandira kuchokera kunjaku (ndi zinthu zoyambira nyama), zomwe sizingakhudze zotsatira za kusanthula kwake.

Mu ana a masiku oyamba amoyo, ntchito yachinsinsi ya kapamba ikalibe kukwana, chifukwa chake, zomwe zili pancreatic elastase m'matumba ndizochepa. Kukula kwachikale, kuchuluka kwa pancreatopeptidase E kumafikira milungu iwiri yokha.

Chidziwitso: kuwerenga kwa ndowe pa elastase-1 kuli ndizodziwika bwino (kumakuthandizani kuti mupeze matenda enaake) komanso kudziwa (mwachangu kanthu pazomwe mukufuna). Kusasokoneza ndi zambiri zazidziwitso (90-94%) za kuwunikaku zimatsimikizira kuti ndiyo njira yabwino kwambiri yowunikira chinsinsi cha kapamba mwa akulu ndi ana ang'ono.

Kuyesedwa kwa pancreatic elastase ndikofunikira kwambiri pakuwunikira kwakanthawi ma cystic fibrosis (kuwonongeka kwa maselo a glandular) ndipo kumachepetsa chiopsezo cha kufa chifukwa cha matenda abwinowa.

Komanso, kudziwa kuchuluka kwa elastase-1 mu ndowe kumapangitsa kudziwa chinsinsi cha kapamba chifukwa cha nthawi yayitali ya kapamba, matenda a ndulu (cholelithiasis), zotupa kapena matenda a shuga.

Kudziwitsa za pancreatic elastase mu ndowe kumatha kuperekedwa kuti mudziwe matenda otsatirawa:

• Cystic fibrosis,
• Matenda apakhungu kapena pachimake,
• Cholelithiasis (miyala mu ndulu ndi zimbudzi zokulira),
• Shuga mellitus (kuphwanya shuga wa kagayidwe m'thupi) ndikulemba I ndi II (wodalira insulini komanso osadalira insulini),
• Lactose tsankho (lactase akusowa),
• Matenda a Crohn (zotupa za m'mimba m'mimba),
• Zochita zoyipa m'makola,
• Opaleshoni yamakina kapena opaleshoni yapanyumba yaposachedwa,
• Matumbo a m'mimba (kupweteka kwambiri mu epigastric dera) kapena kudzimbidwa popanda zifukwa zoyenera,
• Jaundice wovulaza (kuphwanya mapangidwe a bile omwe amayamba chifukwa cha makina (chotupa, masamu) omwe amatseketsa kuwala kwa ndulu ya bile
• Cystic fibrosis wa kapamba.

Kuwona kwa zotsatira za kusanthula kwa elastase-1 mu ndowe kumachitika ndi gastroenterologist, endocrinologist, oncologist, dokotala wa ana, othandizira, opaleshoni, etc.

Mitengo ya Fecal elastase

• Mtunduwo ndi 200 kapena kupitirira kwa μg / g wa ndowe,
• Moder (modekha komanso pang'ono pancreatic secretion insuffence) - kuchokera 100 mpaka 200 μg / g wa ndowe,
• Zowopsa (kuphwanya kwakukulu kwa ntchito ya exocrine pancreatic) - mpaka 100 μg / g ya ndowe.

Zinthu zothandiza pa zotsatirapo zake

• Kuphwanya algorithm posunga zinthu,
• Kuphwanya malamulo osungira chopondapo,
• Kuchita dzulo la kusanthula kwa x-ray, CT, irrigoscopy ndi maphunziro ena pogwiritsa ntchito zosiyana,
• Kudya kwa magnesium, bismuth,
• Kulowetsa mafuta (mchere kapena castor),
• Chithandizo cha antidiarrheal,
• Kugwiritsa ntchito mankhwala ofewetsa tuvi tolimba, ma rectal suppositories kapena enemas tchuthi cha njirayi posungira ndowe.

Zotsatira zake SI zoyendetsedwa ndi zifukwa:

• pancreatic enzyme m'malo mankhwala,
• Chithandizo cha proteinol inhibitors,
• zaka komanso jenda odwala
• zamtundu.

Kukonzekera kwa kusanthula

Masiku 3-4 pamaso pa mayeso, muyenera:

• siyani kumwa mankhwala omwe amakhudza matumbo motility (belladonna, pilocarpine),
• lekani kugwiritsa ntchito mankhwala owonjezera a rectal ndi mafuta.
• lekani kumwa mankhwala othandizira, mafuta a petroli kapena mafuta a castor, mankhwala antidiarrheal,
• Osamatsuka enemas, douching.

Palibe zofunika zapadera pakudya, kupatula poletsa zonunkhira, zokazinga, zamafuta, zosunthidwa ndi mbale zowuma.

Phunziroli silimachitika nthawi ya kusamba kwa akazi mu msambo mwa azimayi ndipo nthawi yomweyo atatha kulowetserera kapena njira zina zodziwira pogwiritsa ntchito barium.

Algorithm posonkhanitsa biomaterial

1. Kutunga ndowe kumachitika m'mawa mutachotsa chikhodzodzo ndikutsuka kwa maliseche ndi anus.
2. Pambuyo poyenda kwamatumbo achilengedwe, mayendedwe a matumbo amasonkhanitsidwa ndi spatula yapadera mumtsuko wapulasitiki. Zakudya zowunikira zitha kugulidwa mwaulere mu uchi uliwonse. bungwe.

Kuchuluka kwa ndowe zofunika phunzirolo mpaka 30% ya kuchuluka kwa chidebe.

• Chidziwitso chotsatirachi chikuwonetsedwa pachidebe: dzina ndi zaka za wodwalayo, tsiku ndi nthawi yosonkhanitsa ndowe.
• Chidebe chokhala ndi biomaterial chimatumizidwa ku labotale akangopeza ndalama. Ngati sizingatheke kuchita izi nthawi yomweyo, ndiye kuti zinthuzo zitha kusungidwa mufiriji kwa maola pafupifupi 5-8 pa kutentha kwa 4-6 ° C.

Kuchulukitsa ndi kuchepa kwa kuchuluka kwa enzyme mu ndowe

Kusintha zizindikiritso sizoyambitsa matenda, chifukwa chake kuchuluka kwa kuchuluka kwa ma pancreatic elastase-1 m'matumba kulibe tanthauzo lachipatala.

Chifukwa chachikulu chochepetsera kuchuluka kwa pancreatic elastase-1 ndi kulephera kwa pancreatic pancreatic kosakwanira kosiyanitsa, kupweteka kwapakati pa neoplasia ya chiwalochi, cystic fibrosis, mtundu 1 kapena mtundu 2 shuga mellitus, granulomatous enteritis kapena kapamba. Zomwe zimayambitsa kuchepa kwa kuchuluka kwa pancreatic elastase-1 mu ndowezo kumatha kukhala mafuta a castor, kuchepa kapena kupindika kwambiri kwa zitsanzo zomwe zapendedwa, kugwiritsa ntchito magnesium ndi bismuth pamankhwala, kapena kuyang'ana kwamatumbo pogwiritsa ntchito x-ray pogwiritsa ntchito njira yosiyanitsa (masiku angapo mayeso asanachitike).

Kodi elastase

Munthu amadya chakudya chambiri tsiku lililonse, chomwe m'mimba mwake chimapangidwa kuti chipukute. Kuti ntchitoyi ichitike moyenera, zinthu zambiri zimapangidwa m'thupi.

Ma enzyme amenewa amathandizira kuphwanya chakudya. Amapangidwa ndi ziwalo zoposa chimodzi. Ntchito yofunika pankhaniyi ndi kapamba.

Madzi a pancreatic amakhala ndi ma enzymes angapo. Pakati pawo pali elastase. Ndikofunikira kuti mapuloteni omwe amalowa mthupi asungidwe kwathunthu.

Ndi kuperewera kwa chinthuchi, njira yogaya chakudya chama protein imasokonezeka, ndipo matenda osiyanasiyana amayamba.

Enzyme imapangidwa kuyambira nthawi yobadwa ndipo imapitilizidwa kupangidwa kwa moyo wonse. Ndi kuchepa kwa ndende yake, kapamba amasokonezeka. Zophwanya zazikulu zimasonyezedwanso ndi mitengo yowonjezeka.

Enzyme iyi ndi yamitundu iwiri:

1. Pancreatic elastase-1. Amapangidwa m'thupi ndipo ndi zinthu zina zimalowa m'matumbo aang'ono, pomwe zimakhudzidwa mwachangu ndi chimbudzi cha chakudya.
2. Whey Kuti muzindikire, kuyezetsa magazi kumaperekedwa.

Chithandizo cha kupatuka kwa zinthu wamba

Chifukwa cha chidwi chachikulu komanso kuyesedwa koyesedwa, kusanthula kuti mupeze kuchuluka kwa elastase mu ndowe ndizodziwika bwino pakuzindikira matenda ambiri mu matenda a endocrinology. Ndi zotsatira za phunziroli, ndikulangizidwa kuti mupitane ndi dokotala - endocrinologist, gastroenterologist kapena katswiri wazachipatala. Kuwongolera zovuta zam'thupi, ndikofunikira kutsatira malamulo onse okonzekera kusanthula.

Kodi limapangidwa kuti?

Pancreatic elastase-1 imapangidwa mu kapamba, kenako imatulutsidwa ngati proelastase m'matumbo ang'onoang'ono pamodzi ndi ma enzyme ena. M'matumbo aang'ono, pansi pa ntchito ya serine proteinase, imasinthidwa kukhala elastase.PE-1 m'matumbo sichikuwonongeka, chifukwa chake kuyika kwake mu chopondapo kuli chisonyezero cha kukhazikitsidwa kwa kuchuluka ndi kapangidwe ka madzi a kapamba omwe amaperekedwa ndi kapamba.

Kodi ndi gulu liti?

Pamodzi ndi chymotrypsin ndi trypsin, elastase ndi gulu la ma serine proteinase. Izi ndichifukwa choti malo omwe amagwira ntchito amakhala ndi serine. Ma enzymes onse omwe adatchulidwa kale amapanga 40% ya kuchuluka kwa mapuloteni amtundu wa exocrine mu kapamba. Onsewa ndi banja limodzi. Pe-1 ili ndi mawonekedwe apamwamba kuposa trypsin. Chifukwa chake, kutseguka kwake kumachitika panthawi yogawa mabatani a peptide opangidwa ndi amino acid. Komanso, elastase imatha kutenga nawo gawo limodzi mwa mapuloteni a elastin, omwe sawola chifukwa cha trypsin ndi chymotrypsin.

Kuzindikira kwa pancreatic elastase mu ndowe nthawi zambiri kumagwiritsidwa ntchito kuti adziwe cystic fibrosis. Chifukwa cha matendawa, cystic fibrosis, yomwe ndi mtundu wa majini, pamakhala kuphwanya kapangidwe kazomwe maselo omwe ali pamitsempha ya zotulutsa. Cystic fibrosis imayambitsa mapapu, m'mimba, impso, matumbo. Pankhaniyi, kuwunika kwa pancreatic elastase kudzawona kuchepa kwakukulu kwa fecal misa. Kuyesedwa kwa chizindikiro ichi ndi njira yofufuzira kwambiri komanso yotsimikizika, yomwe imagwiritsidwa ntchito kwambiri mu gastroenterology, hepatology ndi endocrinology.

Zizindikiro zakusanthula

Kuwunikira kuti muwone mulingo wa kapamba wa kapamba 1 - mutha kuperekedwa kuti mupeze kusakwanira kwa chinsinsi cha kapamba, pakudziwika kwa cystic fibrosis, neoplasms yoyipa, kapamba wamtundu wovuta. Kuphatikiza apo, phunziroli likuwonetsedwa kuti likuwongolera chithandizo cha kuperewera kwa pancreatic enzyme.

Kafukufuku wa pancreatic elastase (chizolowezedwe chawonetsedwa pansipa) akhoza kulembedwa ngati zotsatirazi zikuwonetsedwa:

• Kutsekula m'mimba kapena kudzimbidwa.
• Kufalikira.
• Kupweteka ndi kulemera pamimba mutatha kudya.
• Kuchepetsa kwambiri thupi.
• Sinthani mosasintha, mtundu ndi kununkhira kwa ndowe.
• Kukhalapo ndinyowa zatsalira za osagwidwa chimbudzi chakudya.

Palibe cholakwika pakuwunika uku.

Kukula kwawofuwofu wa ndowe pazomwe zili elastase-1 mmo mutha kufikira 95%, ndi chidwi - pafupifupi 93%. Ubwino wina wa phunziroli ndi kuthekera kotsika kwa pancreatic elastase-1 kumamatira. Izi zimakuthandizani kuti musunge zinthu kwanthawi yayitali, ngati mutsatira zofunikira zonse zosunga.

Kukonzekera kwa kafukufuku ndikusonkha zakuthupi pamayendedwe ake

Pofufuza, muyenera kutenga nyemba. Ndikofunika kuti mupange kusanthula m'mawa, pakatikati kuyambira 7 mpaka 11 m'mawa. Phunziro lisanachitike, chakudya chimaloledwa. Izi ndichifukwa choti elastase yomwe imabwera ndi chakudya m'matumbo sichikuwonongeka ndipo siyingasokoneze zotsatira za kafukufukuyu. Ndikofunika kuti musamamwe mankhwala othandizira kapena osagwiritsa ntchito rectal suppositories kapena kukonzekera kwa barium kwa masiku angapo mayeso asanachitike. Ndikofunikira kupititsa kusanthula kusanachitike kuti musagwiritse ntchito njira zina monga enema kapena colonoscopy.

Mankhwalawa komanso zotsatira za phunziroli pazomwe zili elastase-1 pachondacho zilibe phindu pa mankhwala, zomwe zimaphatikizapo makonzedwe a michere ya pancreatic.

Po sonkhanitsa biomaterial, malamulo angapo ayenera kuwonedwa. Ndikofunikira kuyang'ana kuwuma kwa chidebe ndikuwonetsetsa kuti mkodzo sunalowe mu chopondapo. Kenako muyenera kusamutsa nyemba za ndowe kukhala chidebe chapadera cha 30-60 milliliters ndikutseka mwamphamvu ndi chivindikiro. Mpaka ndowe zitatumizidwa kuti zikafufuze, ziyenera kusungidwa mufiriji. Kutentha kuyenera kukhala pakati pa madigiri asanu ndi asanu ndi atatu. Ndikothekanso kutola ndowe za kafukufukuyu masana, ndipo ngati ndi kotheka, imatha kuzizira pa kutentha kwa -20 madigiri.

Njira yofufuzira

Mukamawunikira, enzyme immunoassay imagwiritsidwa ntchito. Katswiri wa labu amagwiritsa ntchito ma antibodies omwe amatha kuzindikira elastase-1 piritsi la pulasitiki la ELISA. Kenako, zitsanzo za zolembedwazo zimaphatikizidwa ndi ma antibodies. Chizindikiro cha utoto chimayikidwa patsamba la biotin. Chikhazikitso champhamvu chotsimikizika chimatsimikiziridwa ndi spectrophotometry.

Ma enzyme abwinobwino amakhala ndi zotsalira zazomera

Elastase-1 wakhanda wobadwa kumene amakhala wotsika pang'ono kuposa wabwinobwino, koma pofika zaka ziwiri milunguyo imafika pamlingo woyenera. Katswiri wodziwa bwino kwambiri yekha ndi amene ayenera kusanthula zomwe zapezeka. Kutanthauzira kwa zotsatirazi ndi motere.

• Mtengo wa EP> 200 μg / g umawonetsa kugwira ntchito kwapancreatic. Kukwera kwake kumakhala kokwanira, kumathandizira magwiridwe antchito a chiwalo ichi (pancreatic elastase> 500 mcg / g kapena 500 mwabwino).
• Mtengo wa 100-200 mcg / g ndi wochepa pancreatic wosakwanira.
• Mtengo wa EP 3 Ogasiti, 2017

Zizindikiro zakusanthula

Gawani kuwunikira kozungulira kwa elastase nthawi zina.

Monga, ndi:

• kupweteka pakudya
• pakakhala matenda kapamba,
• fibrosis
• kuperewera kwamatenda owonda,
• Matenda a Crohn
• zoyipa, mawonekedwe osakhazikika kapena kukayikira kupezeka kwawo,
• kuvulala kwam'mimba komwe kumatha kusokoneza ntchito ya thupi,
• matenda omwe amayamba mwa anthu chifukwa chakuchotsa ndulu.
• kuwonda msanga,
• amaganiza kuyamba kwa cystic fibrosis,
• Matenda a dyspeptic,
• Yaitali, yopanda matenda otsekula m'mimba.

Zomwe ma pathologies amaulula

Kufufuza ndowe kumathandizira kuzindikira matenda ambiri omwe amayamba chifukwa cha zosintha zotsatirazi:

• zotupa zomwe zimakhudza minofu ya ziwalo,
• kuphwanya kwam'madzi,
• minofu ya parenchymal imawonongeka pang'onopang'ono
• matenda obadwa nawo a ducts a chiwalo.

Njira yofufuzira iyi imakupatsani mwayi wofufuza momwe mungagwiritsire ntchito matenda osiyanasiyana:

• aakulu kapamba
• matenda a chiwindi, kaya akhale otani,
• nthenda ya ndulu, yodziwika ndi kupangidwa kwa miyala mu ndulu ndi maenje ake,
• mawonekedwe a thupi, owonetsedwa mu kusazindikira kwa lactose,
• cystic fibrosis,
• Matenda a Crohn
• khansa

Chifukwa chiyani ndowe zimasonkhanitsidwa kuti zizindikiritse

Enzimuyo imapangidwa m'chiwalo chimodzi chokha ndipo imadutsa m'mimba. Komabe, sizimaphwanya ngakhale pang'ono komanso sizimachepetsa chidwi.

Pambuyo pake, thunthu limasunthira m'matumbo ang'ono ndikusiya mwachilengedwe. Chifukwa chake, kusanthula kwa fecal elastase ndiyo njira yophunzitsira bwino kwambiri.

Kufunika kwa kafukufuku

Elastase ndi enzyme yofunika yomwe imatenga gawo logaya chakudya m'njira zambiri.

Kachulukidwe kake kamakupangitsani kumakupatsani mwayi kuti muwone bwino momwe thupi limakhalira, kapangidwe kazinthu zolephera m'ntchito yake ndikusintha kwa ziwalo za chiwalo. Chifukwa cha izi, kufufuza koyenera kumachitika ndipo matendawa amadziwika munthawi yake, ndipo njira zoyenera zamankhwala zimasankhidwa.

Malamulo Atolera Zinthu

Kuti tidutse izi, ndikokwanira kungotola zinyalala zokha, koma tikulimbikitsidwa kutumiza zosachepera magalamu khumi zofufuza.

Musanagwiritse ntchito pamanja, muyenera kukodza ndikuonetsetsa kuti mukutsuka.

Muyenera kusakaniza ndowe mutangomaliza kuyenda kwamatumbo. Chidebe chapadera chimagwiritsidwa ntchito, chomwe chimadzazidwa ndi chitatu. Zitangochitika izi, imatsekedwa ndi chivindikiro.

Zida zimalimbikitsidwa kuti zizitumizidwa ku labotale mwachangu. Sungani mufiriji saloledwa kuposa maola asanu ndi limodzi.

Njira yofufuzira

Kusanthula kumachitika ndi enzyme immunoassay. Kuti muchite ELISA, gawo loonda la antibody limayikidwa piritsi lopangidwa ndi pulasitiki, lomwe limatha kuzindikira enzyme yokha.

Zitangochitika izi, nyemba za biomaterial zimayikidwa piritsi. Pa gawo la biotin, chizindikiro chimapangidwa pogwiritsa ntchito utoto.

Ndikotheka kudziwa kukula kwa chikhomo pogwiritsa ntchito njira yowonera.

Zotsatira za kutsatsa chidwi

Kutanthauzira kwa zotsatira kuyenera kuchitika kokha ndi dokotala. Ndi iye yekhayo amene angadziwe molondola kwambiri zomwe elastase ikuwonetsa.

Kutembenukira mmwamba kapena pansi sikuti nthawi zonse kumatsimikizira kukula kwa matenda. Chifukwa chake, kudziyesa nokha koletsedwa.

Mukalandira deta kuchokera ku labotale, muyenera kupita kukakumana ndi akatswiri.

Nthawi zonse kwa achikulire

Akuluakulu, njira ya enzyme imaposa 200 μg / g komanso yochepera 500. Pakadali pano, zochitika za kapamba zimachitika popanda zosokoneza.

Tiyenera kudziwa kuti ngati chiwonetserochi chikuchulukirapo 500, ndiye kuti palibe chifukwa chodera nkhawa. Kusintha kwachilengedwe kumawonedwa pakuphatikizidwa kwa 700 μg kapena kuposerapo.

Nthawi zonse kwa ana

Zomwe zimachitika mwa ana a enzyme ndizofanana ndi akulu, ndipo ndizofanana ndi 200-500 mcg. Mwana akakhala wochepa mpaka 100 μg / g, kuyesedwa kwachiwiri kumayikidwa.

Komanso, ana amatha kupanikizika kwambiri (mpaka 700 mcg / g). Pakapita kanthawi, mudzayeneranso kutenganso zinthuzo ku labotale.

Kuchulukitsa

Zizindikiro zotsatsa zomwe zili ndi gawo lalikulu la gawo, momwe elastase imakwezedwa, ndi mfundo izi:

• kudula ululu wam'mimba,
• Khungu lakhungu,
• kuwonda mwadzidzidzi
• kutsegula m'mimba
• ukufalikira
• kumverera kofooka.

Mawonetseredwe ofunikira azakudya ndi awa:

• matenda a ndulu
• oncology
• kapamba

Zotsatirazi zingachititse kuchuluka kwa enzyme:

• kusokonezeka kwachilengedwe kwa maselo ndi kusintha pang'onopang'ono ndi minofu yolumikizana,
• yotupa njira
• kulowetsera,
• kuwonongeka kwa makalata a chinsinsi a chiwalo.

Kuchepetsa

Kuperewera kwa limba chifukwa cha zifukwa zosiyanasiyana.

Monga lamulo, kuchepa kwa chidwi cha zinthu kumayendetsedwa ndi zizindikiro zowonjezera:

• kudzimbidwa
• ndowe zimakhala zachikasu,
• ndowe ndi kukhalapo kwa chithovu ndi zinyalala zopanda chakudya zimawonedwa,
• ndowe zimayamba kufinya, fungo wowonda,
• kupweteka kwapadera m'dera la epigastric,
• kusisita ndi mseru
• atatha matumbo kuyenda, pali zotupa zamagazi ndi ntchofu kuchokera ku anus.

Ma pathologies otsatirawa amatha kupangitsa kusintha motere:

• oncology
• yotupa njira kutukusira m'matumbo,
• kulowetsera,
• cystic fibrosis,
• matenda ashuga
• chiwindi.

Kusintha kwazinthu zamtengo wapatali

Kuzungulira kwa ndulu ya enzyme mwachindunji kumadalira momwe ntchito ya kapamba.

Kuti muwonjezere elastase kapena kuchepetsa mlingo wake, muyenera kuchitapo kanthu pazinthu zomwe zimapanga chinthu ichi. Chofunika kwambiri ndi zakudya.

Muyenera kutsatira malangizo osavuta:

• kudya nthawi zambiri mokwanira, koma pang'ono
• imwani zamadzi zambiri
• kondwerani mbewu monga chimanga ndi msuzi wokonzedwa pamadzi,
• phatikizani mkaka wokazinga mkaka
• Tayani zakudya zokazinga.

Kutengera ndi zifukwa zomwe zinapangitsa kuti zisinthe, sankhani njira zamankhwala osokoneza bongo. Mwanjira iyi, mankhwala othana ndi kutupa ndi mankhwala othandizira amagwiritsidwa ntchito.

Kubwezeretsanso miyezo yabwinobwino ndichinthu chofunikira..

Izi ndichifukwa choti kusakwanira kapena kugwira ntchito kwambiri kwa kapamba, njira zoyambira zimayamba mosagwirizana zomwe zingayambitse zotsatira zoyipa, mpaka pakufa.

Chifukwa chake, ndikofunikira kuti dongosololi lifesedwe mwadongosolo ndikusintha chidziwitsocho ngakhale zitakhala zazing'ono kuchokera kuzowonetsa.

Enzime ya pancreatic imakhudzidwa mu njira zofunika za chimbudzi. Kuchuluka kapena kuchuluka kwake kungasokoneze mkhalidwe wam'mimba komanso thanzi.

Chifukwa cha kusanthula kopindulitsa, ndizotheka kuzindikira kuphwanya koteroko ndikuchotsa vutoli posachedwa.