Ntchito malangizo Trazhenta

Piritsi lililonse lokhala ndi filimu yokhala ndi: yogwira:: linagliptin 5 mg,

zotuluka: mannitol, wowotcha pregelatinized, Copovidone, magnesium stearate, Opadray pink (02F34337) (hypromellose 2910, titanium dioxide (E171), talc, macrogol 6000, red iron oxide (E172).

Mapiritsi a biconvex ozungulira okhala ndi mbali zometedwa, zokutidwa ndi chipolopolo cha mtundu wofiirira, wokhala ndi chithunzi cha kampani mbali imodzi ndikulemba "D5" mbali inayo ya piritsi.

Zotsatira za pharmacological

Linagliptin ndi choletsa wa enzyme dipeptidyl peptidase-4 (apa - DPP-4), yemwe akuphatikizidwa ndi kupangika kwa ma impretins a mahomoni - glucagon-ngati peptide-1 (GLP-1) ndi glucose-insulinotropic polypeptide (GIP). Ma hormone awa amawonongeka mwachangu ndi enzyme DPP-4. Ma hormone onsewa amakhudzidwa ndi kayendedwe ka thupi ka glucose homeostasis. Mlingo woyambira wa insretin secretion masana ndi wotsika, umakwera msanga mutatha kudya. GLP-1 ndi GIP zimathandizira insulin biosynthesis ndi katulutsidwe kake ka pancreatic beta-ketki pazachilendo komanso kukwera kwamagazi a shuga. Kuphatikiza apo, GLP-1 imachepetsa katulutsidwe wa glucagon ndi maselo a pancreatic alpha, omwe amatsogolera kuchepa kwa kupanga kwa shuga mu chiwindi. Linagliptin (TRAGENT) ndiwothandiza kwambiri komanso amagwirizananso ndi DPP-4, zomwe zimapangitsa kuti chiwonetsero chambiri chikhalebe cha ma insretin komanso kusungidwa kwa nthawi yayitali pantchito yawo. TRAGENTA imakulitsa katulutsidwe kamatenda a glucose ndipo amachepetsa katulutsidwe ka glucagon, zomwe zimapangitsa kusintha kwa glucose homeostasis. Linagliptin imamangiriza ku DPP-4 kusankha, mu vitro kusankha kwake kupitilira kusankha kwa DPP-8 kapena ntchito ya DPP-9 nthawi zopitilira 10,000.

Pharmacokinetics

Kuzungulira kwa linagliptin mu plasma kumachepera magawo atatu. Hafu ya theka-yayitali ndi yayitali, yoposa maola 100, makamaka chifukwa cha kumangika kwa linagliptin ndi enzyme ya DPP-4; Kuchita bwino hafu ya moyo, mutatha kubwereza linagliptin pa 5 mg, pafupifupi maola 12. Pankhani ya kumwagliptin pa mlingo wa 5 mg kamodzi patsiku, plasma yokhazikika ya mankhwalawa imatheka pambuyo pa mlingo wachitatu. Munthawi yamapiritsi a pharmacokinetics (mutamwa mankhwalawa 5 mg), AUC (dera lomwe akupanga nthawi yayikulu) ya plasma linagliptin idakulirakulira pafupifupi 33% poyerekeza ndi mlingo woyamba.

Ma coefficients ndi ma coefficients omwe amasinthana pakati pa odwala osiyanasiyana a AUC ya linagliptin anali ochepa (12.6% ndi 28,5%, motsatana). Mitengo ya plasma AUC ya linagliptin yokhala ndi mlingo wowonjezereka idakulirapo pang'ono. Ma pharmacokinetics a linagliptin odzipereka mwaumoyo komanso odwala omwe ali ndi matenda a shuga 2 amakhala ofanana.

Mtheradi wa bioavailability wa linagliptin pafupifupi 30%. Kulandila kwa linagliptin limodzi ndi chakudya chomwe chili ndi mafuta ambiri, nthawi yowonjezera yokwanira Ndi_mosamala Maola 2 ndikuchepetsa C_mosamala 15%, koma sizinakhudze A11Co-72ch- Zotsatira zazikulu pakusintha C_mosamala ndi T_mosamala osayembekezereka. Chifukwa chake, linagliptin ikhoza kugwiritsidwa ntchito limodzi ndi chakudya komanso mosasamala zakudya.

Chifukwa chogwiritsa ntchito mankhwalawa kumankhwala, ambiri amawoneka kuti amagawika malo osungika a pharmacokinetics pambuyo pakulowerera kamodzi kwa linagliptin muyezo wa 5 mg kwa maphunziro abwino ndi pafupifupi 1110 malita, zomwe zikuwonetsa kufalikira kwakanthawi. Kumangidwa kwa lignagliptin ku mapuloteni a plasma kumadalira kuchuluka kwa mankhwalawo ndipo pafupifupi 99% pamatenda a 1 nmol / L, komanso pazowonjezera> 30 nmol / L imatsika mpaka 75-89%, yomwe imawonetsa kuchuluka kwa kumangiriza kwa mankhwalawa ndi DPP-4 ndikuwonjezera kuchuluka kwa lignagliptin . Pazowunikira kwambiri, kukadzaza kwathunthu kwa DPP-4 kumachitika, 70-80% ya linagliptin imamangiriza mapuloteni ena a plasma (m'malo mwa DPP-4), ndipo 30-20% ya mankhwalawo anali mu plasma m'malo osagwirizana.

Pambuyo pakukonzekera kwa pakamwa kwa 14C-linagliptin pa 10 mg ndi mkodzo, pafupifupi 5% ya radioactivity idatulutsidwa. Gawo laling'ono la mankhwala lomwe limalandiridwa limapangidwa. Metabolite imodzi yayikulu idapezeka, ntchito yomwe ndi 13.3% ya zotsatira za linagliptin m'malo opezeka ma pharmacokinetics, omwe alibe zochitika za pharmacological ndipo samakhudza ntchito yoletsa ya lignagliptin mu plasma motsutsana ndi DPP-4.

Patatha masiku 4 kuphatikiza 14C yolembedwa kuti linagliptin mkati mwa maphunziro athanzi, pafupifupi 85% ya mankhwalawa idachotsedwa (ndowe 80% komanso mkodzo 5%). Chilolezo cha impso ku stateacokinetics chokhazikika chinali pafupifupi 70 ml / mphindi.

Matenda aimpso

Kuyesa pharmacokinetics ya linagliptin (pa mlingo wa 5 mg) mwa odwala omwe ali ndi madigiri osiyanasiyana a matenda aimpso ofooka poyerekeza ndi. maphunziro athanzi adachita kafukufuku wotseguka ndi mitundu yambiri ya dosing. Phunziroli lidaphatikizapo odwala omwe amalephera aimpso, omwe adagawikana malinga ndi chilolezo cha creatinine m'mapapo (50 - 2.

Kuwona kusintha malinga ndi jenda la odwala sikofunikira. Kugonana sikunawakhudze kwambiri pharmacokinetics ya linagliptin (malinga ndi zotsatira za kusanthula kwama pharmacokinetic komwe kumachitika potsatira deta ya maphunziro a gawo 1 ndi gawo lachiwiri).

Kusintha kwa Mlingo kutengera zaka za odwala sikofunikira, popeza zaka sizinakhale ndi vuto lalikulu pa pharmacokinetics ya linagliptin. Odwala okalamba (zaka 65-80, wodwalayo wakale. Anali ndi zaka 78) komanso odwala aang'ono, kuchuluka kwa plasma kwa linagliptin kunali kofanana.

Maphunziro a pharmacokinetics a lignagliptin mwa ana sanachitike.

Zizindikiro zogwiritsidwa ntchito

TRAGENT imawonetsedwa kwa odwala akuluakulu omwe ali ndi mtundu wa 2 matenda a shuga kuti athandizire kuwongolera glycemic: monga monotherapy

- kwa odwala omwe ali ndi vuto losakwanira la glycemic pokhapokha kudzera pakudya kapena masewera olimbitsa thupi, komanso kwa iwo omwe sangathe kutenga metformin chifukwa cha tsankho, kapena ngati metformin yatsutsana chifukwa cha vuto laimpso.

- metformin, ngati zakudya ndi masewera olimbitsa thupi osakanikirana ndi metformin sizipereka chiwongolero chokwanira cha glycemic,

- zotumphukira za sulfonylurea ndi metformin, ngati zakudya ndi masewera olimbitsa thupi osakanikirana ndi mankhwalawa sizipereka chiwongolero chokwanira cha glycemic,

- insulin limodzi ndi metformin kapena popanda iyo, ngati zakudya ndi zolimbitsa thupi zomwe zimaphatikizidwa ndi mankhwalawa sizipereka chiwongolero chokwanira cha glycemic.

Mimba komanso kuyamwa

Kugwiritsa ntchito kwa linagliptin mwa amayi apakati sikunaphunzire.

Kafukufuku wazinyama sanawonetse chizindikiro chakubala. Monga njira yopewera, KUTSATIRA kuyenera kupewedwa mukatenga pakati.

Zambiri zomwe zimapezeka mu kafukufuku wa pharmacodynamic mu zinyama zimasonyezera kulowa kwa linagliptin kapena ma metabolites ake mkaka wa m'mawere. Chiwopsezo chowonetsedwa kwa akhanda kapena ana nthawi yoyamwitsa sichimakhudzidwa.

Lingaliro la kusiya kuyamwitsa kapena kumwa TRAG liyenera kutengera phindu la kuyamwitsa khanda ndi kuchira kwa amayi.

Kafukufuku wokhudzana ndi zotsatira za TRAGENT pa chonde chaumunthu sanachitike. Kafukufuku wazinyama sanawonetse vuto lililonse chonde.

Mlingo ndi makonzedwe

Mlingo woyenera ndi 5 mg ndipo amatengedwa nthawi imodzi patsiku.

Pogwiritsa ntchito metformin, mlingo wa metformin uyenera kukhalabe womwewo.

Mukamamwa linagliptin osakanikirana ndi mankhwala a sulfonylurea kapena insulin, mulingo wochepetsetsa wa sulfonylurea kapena zotumphukira za insulin uyenera kuganiziridwa kuti muchepetse chiopsezo cha hypoglycemia.

Matenda aimpso

Odwala ndi mkhutu aimpso ntchito mlingo kusintha siofunika.

Kuwonongeka kwa chiwindi

Kafukufuku wa Pharmacokinetic akuwonetsa kuti kusintha kwa mankhwalawa sikofunikira kwa odwala omwe ali ndi vuto la chiwindi, komabe, palibe chokuchitikirani pakugwiritsira ntchito mankhwalawa kwa odwala mwa odwala.

Kusintha kwa Mlingo kutengera msinkhu sikofunikira.

Komabe, zomwe takumana nazo pa odwala omwe ali ndi zaka zopitilira 80 ndi zochepa, gulu ili la odwala liyenera kumwedwa mosamala.

Ana ndi achinyamata

Chitetezo ndi kugwira ntchito kwa linagliptin kwa ana ndi achinyamata sikunakhazikitsidwe.

Ngati mulingo wa mankhwalawo wakusowa, uyenera kumwedwa wodwala akangokumbukira izi. Osamwa kawiri pa tsiku limodzi.

Zotsatira zoyipa

Kutetezedwa kwa TRAGENT kunayesedwa mwa odwala 6602 omwe ali ndi mtundu wa 2 matenda a shuga, kuphatikiza odwala 5955 omwe atenga muyezo wa 5 mg.

Kafukufuku wolamulidwa ndi placebo anaphatikiza maphunziro momwe linagliptin imagwiritsidwa ntchito motere:

mu mawonekedwe a monotherapy (kugwiritsa ntchito nthawi yochepa, mpaka milungu 4)

monga monotherapy (nthawi> milungu 12) kuwonjezera pa metformin

kuphatikiza kuphatikiza kwa metformin ndi sulfonylureas

supplementation ndi insulini kuphatikiza kapena popanda metformin.

Kukula kwa zoyipa kumasonyezedwa monga: nthawi zambiri (> 1/10), nthawi zambiri (kuchokera> 1/100 mpaka 1/1000 mpaka 1/10000 kupita

Bongo

Panthawi yoyesedwa pamayeso aumoyo wathanzi, Mlingo umodzi wa linagliptin, womwe umafikira 600 mg (nthawi 2000 kuchuluka), anali wololera. Munthu sakumana ndi Mlingo wopitilira 600 mg.

Pankhani ya mankhwala osokoneza bongo, ndikofunika kugwiritsa ntchito njira zofananira zothandizira, mwachitsanzo, kuchotsa mankhwala osagwiritsidwa ntchito m'matumbo, kuyang'anira ndi kulandira chithandizo mogwirizana ndi mawonekedwe a chipatala.

Kuchita ndi mankhwala ena

Mu vitro kugwiritsa ntchito mankhwala

Linagliptin ndi mpikisano wofooka wopikisana ndi CYP3A4 isoenzyme, ndipo choletsa chofooka kapena choperewera cha makina ochitira izi isoenzyme. Linagliptin saletsa zina za CYP isoenzymes ndipo samawalimbikitsa.

Linagliptin ndi gawo lapansi la P-glycoprotein (P-gp) ndipo limalepheretsa pang'ono kuyendetsa P-glycoprotein-Mediated digoxin. Popeza izi ndi zotsatira za kuyanjana ndi mankhwala a vivo, kuthekera kwa linagliptin kuyanjana ndi magawo ena a P-gp kumawerengedwa kuti ndiwokayikitsa.

Mu vivo kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya mankhwala ena pa linagliptin

Zotsatira zakuchipatala izi zikuwonetsa kuyanjana pang'ono kwakanthawi kothandizirana ndi kugwiritsa ntchito mankhwala munthawi yomweyo.

Metformin: kuphatikiza kwa metformin mobwerezabwereza pa mlingo wa 850 mg katatu patsiku ndi linagliptin pa 10 mg 1 nthawi patsiku sizinachititse kuti pakhale kusintha kwakukulu mu pharmacokinetics ya linagliptin mwa odzipereka athanzi.

Zotumphukira za Sulfonylurea: the pharmacokinetics in the equilibrium state of 5 mg ya linagliptin sizinakhudzidwe ndi kuphatikiza limodzi kwa mlingo umodzi wa 1.75 mg wa glibenclamide (glyburide).

Ritonavir: kuphatikiza kwa linagliptin (limodzi mlingo wa 5 mg pakamwa) ndi ritonavir (zingapo Mlingo wa 200 mg pakamwa), inhibitor yogwira ya P-glycoprotein ndi isoenzyme CYP3A4, inakulitsa mfundo za AUC ndi C_tah linagliptin pafupifupi nthawi 2 ndi katatu, motsatana. Kuzungulira kwaulere, komwe nthawi zambiri kumakhala kosakwana 1% ya mankhwala a linagliptin, kumawonjezeka 4-5 pambuyo pothandizidwa ndi ritonavir. Kufanizira kwa plasma wozungulira wa linagliptin m'chigawo chofanana cha pharmacokinetics komanso popanda ritonavir munthawi yomweyo kuyang'anira kunawonetsa kuti kuwonetsa kukhudzana sikuyenera kutsagana ndi kuchuluka kwa kuchuluka kwa lignagliptin. Zosintha izi mu pharmacokinetics za lignagliptin sizofunika kwambiri pakliniki. Chifukwa chake, kuyanjana kwakukulu kwachipatala ndi ma P-glycoprotein / SURZA4 enhibitors sikuyembekezeredwa.

Rifampicin: kugwiritsidwa ntchito mobwerezabwereza kwa 5 mg ya linagliptin ndi rifampicin, gawo lokangalika la P-gp ndi isoenzyme CYP3A4, kunapangitsa kutsika kwa mfundo za AUC ndi C_mosamala lignagliptin, motero, ndi 39,6% ndi 43.8%, ndi kutsika kwa zoletsa zamtundu woyambira wa dipeptidyl peptidase-4 ndi 30%. Chifukwa chake, kufunikira kwa linagliptin, wogwiritsidwa ntchito limodzi ndi P-gp inducers, sikungatheke, makamaka pogwiritsa ntchito kuphatikiza kwa nthawi yayitali. Kugwiritsa ntchito kamodzi ndi mitundu ina yogwira ntchito ya P-gp ndi CYP3A4, monga carbamazepine, phenobarbital ndi phenytoin, sikunaphunzire.

Zotsatira za linagliptin pa mankhwala ena

M'maphunziro azachipatala, monga tawonera pansipa, panalibe zovuta zamankhwala pa pharmacokinetics ya metformin, glyburide, simvastatin, warfarin, digoxin ndi njira zakulera zapakamlomo, zomwe zimatsimikiziridwa mu vivo, ndipo zimatengera kuthekera kotsika kwa linagliptin kulowa mogwirizana ndi mankhwala ndi magawo a CYP3A4 , CYP2C9, CYP2C8, P-dr ndi mamolekyu amakanolo a organic cations.

Metformin: kugwiritsidwa ntchito mobwerezabwereza kwa linagliptin pa mlingo wa 10 mg kamodzi patsiku ndi 850 mg ya metformin, gawo laling'onoting'ono, sikunatsogolera ku pharmacokinetics yofunika kwambiri ya Metformin mwa odzipereka athanzi. Chifukwa chake, linagliptin sichimalepheretsa Uransportag • yolumikizidwa ndi zolengedwa zachilengedwe.

Zotumphukira za Sulfonylurea: kugwiritsa ntchito 5 mg ya linagliptin ndi kumwa kamodzi kwa 1.75 mg wa glibenclamide (gliburide) kunapangitsa kutsika kwakukulu mu AUC ndi C_mosamala glibenclamide ndi 14%. Popeza glibenclamide imapangidwa makamaka ndi CYP2C9, izi zimatsimikiziranso kuti linagliptin si choletsa CYP2C9. Palibe kuyanjana kwakukulu kwachipatala komwe amayembekezeredwa ndi zotumphukira zina za sulfonylurea (mwachitsanzo, glipizide, tolbutamide ndi glimepiride), yomwe, ngati glibenclamide, imapangidwa makamaka ndi CYP2C9.

Digoxin: Kuphatikizidwa mobwerezabwereza kwa 5 mg ya linagliptin ndi 0,25 mg wa digoxin sizinakhudze pharmacokinetics of digoxin mwa odzipereka athanzi. Chifukwa chake, mu vivo linagliptin si choletsa P-glycoprotein-mediated transport.

Warfarin: linagliptin, yogwiritsidwa ntchito mobwerezabwereza pa mlingo wa 5 mg patsiku, sanasinthe pharmacokinetics ya S (-) kapena R (+) warfarin, yomwe ndi gawo la CYP2C9 ndipo imayendetsedwa kamodzi.

Simvastatin: linagliptin atatengedwa ndi odzipereka athanzi pamadontho angapo anali osakhudzidwa kwambiri ndi pharmacokinetics ya simvastatin, gawo laling'ono la CYP3A4. Mutatenga linagliptin pa 10 mg (pamwambapa pamankhwala othandizira) pamodzi ndi simvastatin pamiyeso ya 40 mg kwa masiku 6, AUC ya simvastatin mu plasma yamagazi idakwera ndi 34%, ndipo C_mosamala m'magazi am'magazi - ndi 10%.

Kulera kwapakamwa: kuphatikiza kwa linagliptin pa 5 mg ndi levonorgestrel kapena ethinyl estradiol sikunasinthe ma pharmacokinetics a mankhwalawa.

Njira zopewera kupewa ngozi

TRAGENT sayenera kugwiritsidwa ntchito mwa odwala matenda a shuga 1 kapena mankhwalawa a matenda ashuga a ketoacidosis.

Zomwe zimachitika mu hypoglycemia pakugwiritsa ntchito linagliptin monga monotherapy zinali zofanana ndi placebo.

M'maphunziro azachipatala, zidanenedwa kuti zochitika za hypoglycemia pakugwiritsa ntchito linagliptin kuphatikiza ndimankhwala omwe samakhulupirira kuti amayambitsa hypoglycemia (metformin, thiazolidinedione derivatives) anali ofanana ndi zotsatira zogwirizana za placebo.

Mukamamwa linagliptin kuwonjezera pa mankhwala a sulfonylurea (ndi mankhwala a metformin oyambira), kuchuluka kwa matenda a hypoglycemia kumawonjezereka poyerekeza ndi gulu la placebo.

Zochokera ku sulfonylureas ndi insulin zingayambitse hypoglycemia. Linagliptin osakanikirana ndi mankhwala a sulfonylurea ndi / kapena insulin ayenera kumwedwa mosamala. Ngati ndi kotheka, kuchepetsa kuchepa kwa sulfonylurea kapena mankhwala a insulin.

Pogulitsa pambuyo pa ntchito ya linagliptin, malipoti onena za kukhazikika kwa kapamba am'mimba adalandiridwa. Odwala ayenera kudziwitsidwa ndi chizindikiro cha pancreatitis yayikulu yamkati: kupweteka kwam'mimba kosalekeza. Pancreatitis regression iwonedwa atasiya ntchito ya linagliptin. Ngati pancreatitis ikukayikira, TRAG iyenera kusiyidwa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Trazenta imapezeka m'mapiritsi okhala ndi filimu: biconvex, yozungulira, yopindika, yopingasa, yofiyira, yokhala ndi D5 mbali imodzi ndi chizindikiro cha kampani yopanga inayo (ma PC 7. M'matumba, pamatumba 2, 4 kapena 8 matuza, ma PC 10. M'matumba, pamatumbu 3 a matuza 3.

Mapangidwe piritsi limodzi:

• yogwira mankhwala: linagliptin - 5 mg,
• othandizira zigawo: pregelatinized wowuma, Copovidone, wowuma chimanga, magnesium stearate, mannitol,
• filimu pachimake: Opadray pink 02F34337 (titanium dioksidi, macrogol 6000, talc, hypromellose, utoto wa iron okusayidi).

Mlingo ndi makonzedwe

Mapiritsi ozindikira amatengedwa pakamwa. Kumwa mankhwalawa sikudalira nthawi yakudya ndipo kumatha kuchitika nthawi ina iliyonse masana.

Mlingo woyenera ndi piritsi 1 kamodzi patsiku.

Mlingo wotsatira ukaphonya, wodwalayo ayenera kumwa mankhwalawo akakumbukira piritsi lomwe linasowa. Onjezani mlingo ndi kumwa mapiritsi awiri tsiku limodzi sayenera kukhala.

Ngati chiwindi ndi / kapena impso ntchito, ndi odwala okalamba, kusintha kwa mankhwala sikofunikira.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimadziwika ndi monotherapy ndi Trazent komanso kuphatikiza pamodzi ndi othandizira ena a hypoglycemic:

• m'mimba dongosolo: kapamba,
• kupuma dongosolo: chifuwa,
• chitetezo chamthupi: Hypersensitivity zimachitika,
• matenda opatsirana: nasopharyngitis.

Mankhwala otsatirawa monga gawo la zovuta mankhwala angayambitse zina zowonjezera:

• pioglitazone, metformin ndi pioglitazone: hyperlipidemia ndi kulemera,
• zochokera sulfonylurea zochokera ku: hypertriglyceridemia,
• insulin: kudzimbidwa,
• zotumphukira za sulfonylurea ndi metformin: hypoglycemia.

Munthawi yakuwonera kugulitsa, zotsatira zoyipa kuchokera ku kachitidwe ndi ziwalo zotsatirazi zidadziwika:

• kugaya chakudya dongosolo: ulceration wa mucous nembanemba wamkamwa,
• chitetezo chamthupi: urticaria, edema ya Quincke,
• khungu: zotupa.

Malangizo apadera

Mukamagwiritsa ntchito mankhwala Trazhenta munthawi yomweyo ndi zotumphukira za sulfonylurea, muyenera kusamala, popeza izi zimayambitsa hypoglycemia. Ngati ndi kotheka, ndi kotheka kuchepetsa mlingo wa mankhwala a sulfonylurea.

Trazhenta sikuchulukitsa chiopsezo cha matenda opatsirana ndi mtima.

Ngati pancreatitis yachuma ikukayikira, mankhwalawo ayenera kusiyidwa.

Kafukufuku wapadera wazomwe zimachitika linagliptin pa kuthekera koyendetsa magalimoto ndi kugwira ntchito ndi njira zoopsa sizinachitike. Ngakhale izi, chifukwa cha chiwopsezo cha chizungulire, munthawi ya mankhwala ndi mankhwalawa, kusamala kuyenera kuchitika pochita zinthu zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo mankhwala a Trazhenta omwe ali ndi metformin, glibenclamide, simvastatin, pioglitazone, warfarin, digoxin, rifampicin, ritonavir ndi njira yolerera pakamwa, pharmacokinetics ya lignagliptin ndi mankhwala omwe adatchulidwa sizinasinthe kapena sanasinthe kwenikweni.

Njira zogwiritsira ntchito Trazenti ndi Mlingo

Trazhenta amatengedwa pakamwa muyezo wa 5 mg (piritsi 1) kamodzi patsiku.

Chogwiritsidwacho chimatengedwa nthawi iliyonse masana, mosasamala chakudya, makamaka tsiku lililonse nthawi imodzi. Ngati piritsi limodzi lakusowa, mutha kumwa nthawi iliyonse wodwala akakumbukira izi, koma osavomerezeka kuti mumwe mlingo umodzi mu tsiku limodzi.

Zowonjezera

Mankhwala omwe amachokera ku sulfonylureas, nthawi zambiri, amathandizira kukulitsa kwa hypoglycemia. Chifukwa chake, nthawi zina, ndizotheka kuchepetsa mlingo wake mukamapereka mankhwala ndi Trazhenta.

Kwa odwala omwe amalephera kwambiri aimpso, mankhwalawa amalimbikitsidwa kuti amwe limodzi ndi mankhwala ena a hypoglycemic.

Malinga ndi ndemanga, Trazhenta ndi analogue amachepetsa kwambiri kuchuluka kwa hemoglobin wa glycosylated ndi glucose akamamwa mapiritsi osala.

Chifukwa cha chizungulire, kuthekera kumalangizidwa mosamala poyendetsa magalimoto ndi makina olemera panthawi ya mankhwala.

Malangizo a Trazent akuwonetsa kuti mapiritsi amayenera kusungidwa m'malo amdima, owuma, ozizira komanso osatheka ndi ana.