Mitundu ya Humalog

Type 1 shuga mellitus nthawi zonse imafunikira mankhwala a insulin, ndipo matenda a shuga a 2 nthawi zina amafunikira insulin. Chifukwa chake, pakufunika kuwongolera kwamahomoni ena. Musanagwiritse ntchito mankhwalawa, munthu ayenera kuphunzira za mankhwalawo, kupweteketsa, kuwonongeka, mtengo, ndemanga ndi analogi, funsani dokotala ndi kudziwa mtundu wake.

Humalog ndi ma analogue opanga a timadzi totsitsa shuga. Imakhudza kanthawi kochepa, kuwongolera kayendedwe ka glucose metabolism m'thupi ndi msinkhu wake. Tiyenera kudziwa kuti glucose imadziunjikira m'chiwindi ndi minofu ngati glycogen.

Kutalika kwa mankhwalawa kumatengera zinthu zambiri, kuphatikizapo zomwe wodwalayo ali nazo. Mwachitsanzo, mwa wodwala yemwe ali ndi matenda a shuga a 2, mukamagwiritsa ntchito mankhwala a hypoglycemic ndi insulin, amawongolera kwambiri shuga. Mankhwalawa amathandizanso kuchepa kwambiri kwa glucose pakugona usiku wonse odwala matenda ashuga. Pankhaniyi, matenda a chiwindi kapena impso sasokoneza kagayidwe ka mankhwala.

Mankhwala Humalog amayamba hypoglycemic pambuyo pakulowetsa kwa mphindi 15, motero odwala matenda ashuga nthawi zambiri amapanga jakisoni asanadye. Mosiyana ndi mahomoni achibadwa achilengedwe, mankhwalawa amakhala kwa maola 2 mpaka 5 okha, kenako 80% ya mankhwalawa imatsitsidwa ndi impso, 20% yotsalayi - chiwindi.

Chifukwa cha mankhwalawa, kusintha koteroko kumachitika:

1. kuthamanga kwa kaphatikizidwe kabwino,
2. kuchuluka kwa amino acid,
3. Kuchepetsa kuwonongeka kwa glycogen kusandulika shuga,
4. zoletsa kusintha kwa glucose kuchokera mapuloteni zinthu ndi mafuta.

Kutengera ndi kuchuluka kwa zinthu zomwe zimagwira, Lispro insulin, mitundu iwiri ya mankhwala imatulutsidwa pansi pa dzina la Humalog Remix 25 ndi Humalog Remix 50. Poyambirira, yankho la 25% ya mahomoni opanga ndi 75% ya kuyimitsidwa kwa protamine amapezeka, kwachiwiri, zomwe zili zawo ndi 50% mpaka 50%. Mankhwala amakhalanso ndizinthu zochepa zowonjezera: glycerol, phenol, metacresol, zinc oxide, dibasic sodium phosphate, madzi osungunuka, sodium hydroxide 10% kapena hydrochloric acid (yankho la 10%). Mankhwalawa onse amagwiritsidwa ntchito pa matenda a shuga omwe amadalira insulin komanso osadalira insulin.

Ma insulini opanga oterewa amapangidwa mwa mawonekedwe a kuyimitsidwa, omwe ndi oyera. Thonje loyera komanso madzi ochulukirapo pamwamba amatha kupanga, ndikusokonekera, kusakaniza kumakhalanso kopanda paliponse.

Kuyimitsidwa kwa Humalog 25 25 ndi Humalog Mix 50 kuyimitsidwa kumapezeka m'mabotolo atatu a 3 ml ndi m'ming'alu ya syringe.

Malangizo ogwiritsira ntchito mankhwalawa

Kwa mankhwala osokoneza bongo, cholembera cha syringe chapadera cha Quick Pen chimapezeka kuti chitha kugwiritsidwa ntchito mosavuta. Musanagwiritse ntchito, muyenera kuwerengera Maupangiri Ogwiritsira Ntchito. Kathumba ka insulin kakufunika kuti kakulidwe pakati pa manja m'manja kuti kuyimitsidwa kukhale kopanda pake. Ngati mukupezeka tinthu tachilendo mkati mwake, mankhwalawa ndibwino kuti musagwiritse ntchito konse. Kuti mulowe chida molondola, muyenera kutsatira malamulo ena.

Sambani manja anu mosamala ndikuwona malo omwe adzapange jekeseniyo. Kenako, kuchitira malowa ndi antiseptic. Chotsani kapu yoteteza ku singano. Pambuyo pa izi, muyenera kukonza khungu. Gawo lotsatira ndikuyika singano mobisalira molingana ndi malangizo. Pambuyo pochotsa singano, malowa ayenera kukanikizidwa osasenda. Pa gawo lomaliza la njirayi, singano yomwe imagwiritsidwa ntchito imatsekedwa ndi chipewa, ndipo cholembera cha syringe chimatsekedwa ndi chipewa chapadera.

Malangizo omwe adatsekedwawa ali ndi chidziwitso chokha chomwe dokotala yekha ndi amene angatchule mlingo woyenera wa mankhwalawa komanso kaimidwe ka insulin, poperekera shuga m'magazi a wodwalayo. Pambuyo pogula Humalog, malangizo ogwiritsira ntchito ayenera kuphunziridwa mosamala. Muthanso kudziwa zamalamulo opereka mankhwalawo momwemo:

• mahomoni opanga amaperekedwa pokhapokha, amakanizidwa kulowa nawo mkati,
• Kutentha kwa mankhwalawa panthawi ya makonzedwe sikuyenera kutsika kuposa kutentha kwa chipinda,
• jakisoni amapangidwa ntchafu, matako, phewa kapena pamimba,
• masamba ena obayira
• popereka mankhwalawa, muyenera kuwonetsetsa kuti singano sikuwonekera mukuwoneka bwino kwa zotengera,
• pambuyo insulin, malo jakisoni sangathe kuzunzika.

Musanagwiritse ntchito, kusakaniza kuyenera kugwedezeka.

Alumali moyo wa mankhwala ndi zaka zitatu. Nthawi iyi ikatha, kugwiritsa ntchito kake kumaletsedwa. Mankhwalawa amasungidwa pamtunda kuchokera 2 mpaka 8 madigiri popanda mwayi wowunika.

Mankhwala omwe amagwiritsidwa ntchito amasungidwa pa kutentha osaposa madigiri 30 kwa masiku 28.

Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Zoyimira m'malo, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira

Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?

Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina.Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Malangizo a Humalog

Fomu ya Mlingo:

kuyimitsidwa koyenda

Machitidwe

Kusakaniza kwa lyspro insulin - kukonzekera insulin mwachangu komanso kuyimitsidwa kwa protamine kuyimitsidwa kwa lyspro insulin - kukonzekera kwa insulini pakukonzekera. Lyspro insulin ndi anomuyumu ya DNA yobwerezabwereza ya insulin yaumunthu; imasiyana mwakutero kwa proline ndi lysine amino acid zotsalira pamalo 28 ndi 29 a insulin B. Imayendetsa kagayidwe ka glucose, imakhala ndi zotsatira za anabolic. Mu minofu ndi minyewa ina (kupatula bongo) imathandizira kusintha kwa glucose ndi ma amino acid kulowa mu khungu, kumalimbikitsa kupangika kwa glycogen kuchokera ku glucose mu chiwindi, kutsutsana ndi gluconeogeneis ndikuthandizira kusintha kwa glucose ochulukirapo kukhala mafuta. Zofanana ndi insulin yaumunthu. Poyerekeza ndi insulin yaumunthu wamba, imadziwika ndi kuyamba mwachangu, kuyambika koyambirira kwa kanthu komanso nthawi yayifupi ya hypoglycemic zochita (mpaka maola 5). Kuyambanso mwachangu (mphindi 15 pambuyo pa kupangika) kumalumikizidwa ndi kuchuluka kwa mayamwidwe ndipo kumalola kuti liperekedwe nthawi yomweyo musanadye (kwa mphindi 15) - insulin yachibadwa yamunthu imaperekedwa kwa mphindi 30. Kusankha kwa jakisoni wambiri ndi zinthu zina kungakhudze kuchuluka kwa mayamwidwe ndi kuyamba kwake. Kuchuluka kwake kumawonedwa pakati pa maola 0.5 ndi 2,5, kutalika kwa nthawi ndi maola 3-4.

Zowonetsa:

Type 1 shuga mellitus, makamaka ndi tsankho la ma insulin ena, postprandial hyperglycemia yomwe singathe kuwongoleredwa ndi ma insulin ena: kuthana kwambiri kwa insulini kukana (kuthamangitsa kuchepa kwa insulin). Type 2 shuga mellitus - mu milandu kukana m`kamwa hypoglycemic mankhwala, kuphwanya mayamwidwe ena insulin, pa ntchito, matenda apakati.

Zoyipa:

Hypersensitivity, hypoglycemia, insulinoma.

Zotsatira zoyipa:

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kuchepa kwa magazi), lipodystrophy, zolakwika zosakhalitsa (nthawi zambiri mwa odwala omwe sanalandire insulin kale), hypoglycemia, hypoglycemic coma. Zizindikiro: ulesi, thukuta, thukuta lotupa, tachycardia, kunjenjemera, njala, nkhawa, paresthesias mkamwa, kutsekemera kwa khungu, kupweteka mutu, kunjenjemera, kusanza, kugona, kugona tulo, mantha, kuthedwa nzeru, kukwiya, zachilendo, kusatsika koyenda, kusalankhula bwino ndi masomphenya, chisokonezo, chikomokere, kupweteka. Chithandizo: ngati wodwalayo akudziwa, adamulamula kuti adzipatsanso dextrose pakamwa, s / c, i / m kapena iv pobayira glucagon kapena iv hypertonic dextrose solution. Ndi chitupa cha hypoglycemic coma, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayamwa kudzera mu mtsempha kulowa kufikira wodwalayo atatuluka.

Mlingo ndi makonzedwe:

Mlingo umatsimikiziridwa payekha kutengera mulingo wa glycemia. Kusakaniza kwa 25% insulin lispro ndi 75% kuyimitsidwa kwa protamine kuyenera kuperekedwa kokha s / c, nthawi zambiri mphindi 15 musanadye. Ngati ndi kotheka, mutha kulowa limodzi ndi insulin yokonzekera nthawi yayitali kapena ndi sulfonylureas pakamwa. Majakisoni amayenera kupangidwa m'ma s, mapewa, matako, matumbo. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Ndi s / c makonzedwe, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.Odwala omwe ali ndi vuto laimpso komanso / kapena chiwindi, kuchuluka kwa insulin yozungulira kumakulitsidwa, ndipo kufunika kwake kumachepetsedwa, komwe kumafunikira kuwunika moyenera kuchuluka kwa glycemia ndi kusintha kwa insulin.

Malangizo apadera:

Njira yoyendetsera njira yomwe ikugwiritsidwa ntchito ikuyenera kuonedwa bwino. Posamutsa odwala kuchokera ku insulin yomwe ikuyenda mwachangu kuchokera ku insulin lispro, kusintha kwakufunikira kungafunike. Kusamutsidwa kwa odwala omwe amalandira insulin tsiku lililonse mlingo wopitilira 100 kuchokera ku mtundu umodzi wa insulin kupita kwa ena ndikulimbikitsidwa kuti upangidwe mu chipatala. Kufunika kwa insulin kumatha kuwonjezeka panthawi yomwe matenda opatsirana, ndi nkhawa zam'maganizo, ndi kuchuluka kwa chakudya chamagulu ambiri, pakudya kowonjezereka kwa mankhwala omwe ali ndi vuto la hyperglycemic (mahomoni a chithokomiro, GCS, kulera kwapakamwa, thiazide diuretics). Kufunika kwa insulin kumatha kuchepa ndi kuchepa kwaimpso komanso / kapena chiwindi, ndi kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya, kuwonjezera kuchuluka kwa thupi, panthawi yowonjezera ya mankhwala omwe ali ndi vuto la hypoglycemic (Mao inhibitors, osasankha beta-blockers, sulfonamides). Chizolowezi chokhala ndi hypoglycemia chitha kupangitsa kuti odwala azichita nawo mwachangu magalimoto, komanso kukonza makina ndi zida zina. Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia mwa iwo kudzera pakudya shuga kapena zakudya zopatsa mphamvu zamafuta (tikulimbikitsidwa kuti nthawi zonse muzikhala ndi shuga osachepera 20 g). M'pofunika kudziwitsa adokotala za hypoglycemia yomwe yasamutsidwa kuti athetse vuto la kusintha kwa mankhwalawa. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndikuwonjezereka mu gawo lachiwiri mpaka lachitatu. Panthawi yobereka komanso pambuyo pawo, kufunika kwa insulin kumatha kuchepa kwambiri.

Kutulutsa Fomu

• Njira yothetsera vutoli ndi yopanda utoto, yowonekera m'makatoreji atatu a 3 ml mu paketi yonyamula m'makatoni olemba nambala 15.
• Katoni yomwe ili mu cholembera cha syringe ya QuickPen (5) ili pabokosi la makatoni.
• Humalog Remix 50 ndi Humalog Remix 25 ikupezekanso.Insulin Humalog Mix ndi osakaniza mu gawo limodzi la Lizpro yochepa-insulin solution ndi Lizpro insulin kuyimitsidwa ndi nthawi yayitali.

Mankhwala

Humalog Mix 50 ndi msanganizo wopangidwa wokonzeka wokhala ndi 50% yankho la lyspro insulin (analog yothamanga ya insulin yaumunthu) ndi kuyimitsidwa kwa 50% ya protamine kuyimitsidwa kwa inspro insulin (njira yapakatikati ya insulin analog).

Katundu wamkulu wa mankhwalawa ndi kukhazikitsidwa kwa kagayidwe ka glucose. Ilinso ndi zotsutsa-catabolic komanso anabolic zotsatira zosiyanasiyana za thupi. Mu minofu yamatenda motsogozedwa ndi Humalog Remix 50, zomwe zimakhala ndimafuta, glycerol ndi glycogen, kuphatikiza mapuloteni kumalimbikitsidwa, ndipo kumwa ma amino acid kumakulitsidwa. Izi zimachepetsa glycogenolysis, gluconeogeneis, lipolysis, ketogenesis, mapuloteni catabolism ndi kutulutsidwa kwa ma amino acid.

Zakhazikitsidwa kuti insulin lyspro imakhala ndi molarity wofanana ndi insulin yaumunthu, koma zotsatira zake zimakula mwachangu komanso zimakhala zochepa.

Pambuyo pakhungu pansi pa khungu, kuyambika kwa msambo wa lyspro insulin ndi kuyamba kwake kwa pachimake. Humalog Remix 50 imayamba kugwira ntchito pafupifupi mphindi 15 pambuyo pa kubayidwa, kotero imatha kutumikiridwa musanadye (mu mphindi 0 mpaka 15), mosiyana ndi insulin wamba.

Mbiri ya insulin lysproprotamine imafanana ndi mbiri ya insulin isofan yotalika pafupifupi maola 15.

Pharmacokinetics

Pharmacokinetics ya Humalog Remix 50 imatsimikiziridwa ndi mphamvu ya pharmacokinetic yazinthu zake ziwiri zogwira ntchito.

Kuchuluka kwa mayamwa ndi kuyambika kwa mankhwala kumadalira malo oyimitsidwa (ntchafu, pamimba, matako) ndi mlingo wake, komanso pazochitika zolimbitsa thupi za wodwalayo, kutentha kwake kwa thupi ndi magazi.

Lyspro insulin pambuyo subcutaneous makonzedwe mofulumira odzipereka. Kuchuluka kwa ndende m'magazi kumafika pambuyo pa mphindi 30-70.

Ma paracokinetic magawo a lysproprotamine insulin ndi ofanana ndi isofan insulin (sing'anga-insulin).

Mwa kuperewera kwa impso ndi kwa hepatic, inshuwaransi ya lyspro imayamwa mwachangu kwambiri kuposa insulin yaumunthu.

Contraindication

• achina,
• wazaka 18
• Hypersensitivity ku gawo lililonse la Humalog Mix 50.

• aimpso / chiwindi kulephera,
• kupsinjika mtima, kuchuluka kwa zochita zolimbitsa thupi, kapena kusintha kwa zakudya zabwinobwino (kusintha kwa mankhwala a insulin kungafunike),
• Kutalika kwa matenda a shuga, matenda ashuga, kapena kugwiritsa ntchito nthawi yomweyo kwa beta-blockers (mwina kusintha kapena kuchepa kwake kwa zizindikiro zoneneratu za hypoglycemia),
• mimba ndi nthawi yoyamwitsa.

Humalog Sakanizani 50, malangizo ogwiritsira ntchito: njira ndi mlingo

Humalog Mix 50 idapangidwa kuti ikwaniritse makina oyang'anira okha. Mutha kulowa nawo musanadye kapena musanadye. Mlingowo umatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense, potengera kuchuluka kwa shuga m'magazi.

Mutha kulowa mankhwalawa pamimba, ntchafu, phewa kapena matako. Masamba obayira ayenera kusinthidwa kuti, pamalo omwewo, kuyimitsidwa ndikuyenera, ngati kungatheke, osaperekanso kamodzi pamwezi.

Mukamayambitsa Humalog Mix 50, chisamaliro chiyenera kutengedwa kuti aletse kuyimitsidwa kulowa mitsempha yamagazi. Palibenso chifukwa chokwanira kupukusa jekeseni pambuyo pa jekeseni.

Kugwiritsa ntchito mankhwalawa makatiriji

Malangizo a kukhazikitsa cartridge mu chipangizo chothandizira kupangira mankhwalawo ndi malingaliro othandizira kuti apange singano isanachitike makonzedwe akufotokozedwa mu malangizo a wopanga chipangizocho kupangira insulin. Ndikofunikira kutsatira mosamalitsa njira.

Asanakhazikitsidwe, mankhwalawa amayenera kutentha. Nthawi yomweyo jekeseni isanachitike, makatoni amayenera kugubudwa kakhumi pakati pa manja ndikugwedezeka kanthawi 10, kutembenuka ndi 180 °, kotero kuti insulini yatsitsimuka, i.e. Simuyenera kuchita kugwedeza bokosi mwamphamvu, chifukwa pamenepa thovu lingapangike, zomwe zimapangitsa kukhala kovuta kukhazikitsa mulingo woyenera. Kuti zithandizire kusakanikirana kwa mankhwalawa, mpira wamgalasi yaying'ono umaperekedwa mkati mwa cartridge.

Ngati pambuyo poyambitsa kuyimitsidwa sikupezeka mosasunthika (ma flakes akuwoneka), sangathe kugwiritsidwa ntchito!

Malamulo akukhazikitsa mtundu wa Humalog Mix 50:

1. Sambani manja.
2. Sankhani jakisoni ndikupanga khungu, kutsatira malangizo a dokotala.
3. Chotsani kapu yakunja yoteteza ku singano.
4. Sinthani khungu lanu mwakuwusakaniza khola laling'ono.
5. Ikani singano pansi pa khungu mumkhola ndikuchita jakisoni, kutsatira njira zogwiritsira ntchito cholembera.
6. Kuti muchotse singano ndi swab thonje, pofinyani pang'onopang'ono malo a jekeseni kwa masekondi angapo. Osatupa malo a jakisoni.
7. Tulutsani singano pogwiritsa ntchito chophimba chakunja ndi kutaya.
8. Ikani chipewa pa cholembera.

Kugwiritsa ntchito Humalog Remix 50 mu syringe yachangu

Cholembera Chachangu penipeni ndi chipangizo chapadera chopangira insulin (cholembedwa kuti cholembera cha insulin). Muli 3 ml ya mankhwalawa (300 IU), imakulolani kuti mulowe kuyambira 1 mpaka 60 magawo a insulin pa jakisoni, ndipo mlingo wake umatha kukhazikitsidwa molondola gawo limodzi.

Mtundu wamtambo wa syringe thupi la QuickPen amawonetsa kuti adapangidwa kuti azigwiritsidwa ntchito ndi zinthu za Humalog.Mtundu wa batani la jakisoni pak cholembera ulusi umagwirizana ndi mtundu wa Mzere pa cholembera cholembera ndipo zimatengera mtundu wa insulin.

Chikwangwani cha QuickPen Syringe chimalimbikitsidwa kuti chizigwiritsidwa ntchito ndi singano zoyenera zopangidwa ndi Becton, Dickinson ndi Company (BD).

Cholembera chilichonse cha syringe chimapangidwa kuti chizigwiritsa ntchito payekha. Osazipatsira ena, chifukwa izi zimabweretsa chiopsezo chotenga matenda opatsirana. Pa jakisoni aliyense, muyenera kugwiritsa ntchito singano yatsopano ndikuonetsetsa kuti imalumikizidwa kwathunthu ndi cholembera asanalowe.

Sizoletsedwa kugwiritsa ntchito cholembera ngati gawo lake lililonse lasweka kapena lowonongeka. Ndikulimbikitsidwa kuti odwala nthawi zonse amakhala ndi syringe yopanda pake ngati atayika kapena atayika.

Humalog Mix 50 mu cholembera cha syPinge ya QuickPen sikulimbikitsidwa kuti igwiritsidwe ntchito palokha ndi odwala omwe ali ndi vuto la kuwona.

Malangizo okonzekera jekeseni:

1. Tsatirani mosamala malamulo a antiseptics ndi asepsis omwe adalimbikitsidwa ndi dokotala.
2. Sambani manja.
3. Sankhani malo pobayira, pukuta khungu.

Malangizo pakukonzekera QuickPen Syringe pen ndi kuyambitsa kwa Humalog Remix 50:

1. Kokani chipewa cha cholembera. Osazungulira kapu, osachotsa chizindikiro pa syringe. Onetsetsani mtundu woyenera wa insulini komanso kufunika kwa alumali. Onani mawonekedwe akuimitsidwa.
2. Tengani singano yatsopano. Chotsani chomata pamapepala akunja. Pukutani disc ya mphira kumapeto kwa cholembera ndi thonje lomwe limasungunuka ndi mowa. Ikani singano mu chipewa pa syringe cholembera mwachindunji molumikizana ndi nkhwangwa mpaka itakhala yolumikizidwa kwathunthu.
3. Chotsani kapu yakunja kuchokera singano (musataye). Kenako chotsani chophimba chamkati (chitha kutayidwa).
4. Chongani cholembera kuti mupeze insulin (mawonekedwe achinyengo). Izi zikuyenera kuchitika nthawi iliyonse jekeseni isanakwane, kuonetsetsa kuti cholembera chilili chakonzeka kumayambiriro kwa mankhwala ofunikira, apo ayi mutha kulowa muyezo wochepa kwambiri kapena waukulu.
5. Konzani khungu pakukoka ndikusonkhanitsa khola lalikulu. Ikani singano pansi pa khungu monga momwe adalimbikitsira ndi dokotala. Sinthani batani la kuchuluka kwa manambala a insulin. Kanikizani batani mwamphamvu ndi chala chamanja molunjika. Kuti mulowetse muyezo wokwanira, gwiritsani batani ndipo pang'onopang'ono muwerenge mpaka 5.
6. Chotsani singano ndikudikirira pang'ono malo a jakisoni ndi swab ya thonje kwa masekondi angapo osapukusira. Kupezeka kwa dontho la mankhwala kumapeto kwa singano ndichinthu chachilendo chomwe sichikhudza mlingo. Ngati kuyimitsidwa kwatuluka singano, mwina wodwalayo sanagwiritse singano pansi pakhungu nthawi yayitali yokwanira kukonzekera mankhwalawo.
7. Gwirizanitsani kapu yakunja ndi singano. Chotsani mu cholembera kuti tiletse mabulawuti kulowa pakatoni.

Ngakhale manambala pawindo la chizindikirocho amasindikizidwa mu manambala, osamvetseka - pogwiritsa ntchito mizere yolunjika pakati pa manambala.

Ngati mukufunikira kulowa muyezo pazochulukitsa kuchuluka kwa ma insulin omwe atsalira mu cartridge, mutha kulowa mankhwala otsalawo ndikugwiritsa ntchito cholembera chatsopano kapena nthawi yomweyo gwiritsani ntchito cholembera chatsopano.

Musayese kusintha mlingo wa insulin panthawi ya jakisoni.

Chidziwitso chofunikira! Cholembera sichingakulorerenso kuti muyike mlingo mopitilira kuchuluka kwa zigawo zomwe zimatsalira mu cartridge. Wodwala akakhala kuti sakudziwa kuti wapereka mlingo wonse wambiri, ndiye kuti sayenera kutumikiridwa.

Zinthu zosunga ndi kutaya cholembera:

• osagwiritsa ntchito cholembera ngati chasungidwa kunja kwa firiji kupitilira nthawi yomwe idafotokozedwa,
• osasunga cholembera ndi singano yomwe idalumikizidwa (mankhwalawa amatha kutayikira kapena kupukuta mkati mwa singano, ndikupangitsa kuti ikhale yotsekedwa, thovu lakuthwa mkati mwa katoni lingayambenso),
• zolembera zosagwiritsidwa ntchito ziyenera kusungidwa mufiriji pa kutentha kwa 2-8 ° C. Simungagwiritse ntchito mankhwalawa ngati mwazizira,
• cholembera chomwe chikugwiritsidwa ntchito pakalipano chimayenera kusungidwa kutentha kwambiri (osapitirira 30 ° C), kutali ndi kuwunikira kwa dzuwa ndi magwero a kutentha,
• singano zogwiritsidwa ntchito ziyenera kutayidwa mu zotengera zotsekeka, zotetezedwa kuti musalembe,
• Chidebe cha singano chodzaza sichizikonzanso,
• zolembera za syringe (zopanda singano) ziyenera kutayidwa malinga ndi upangiri wa dokotala ndi malamulo am'deralo otaya zinyalala zamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimadziwika kwambiri ndi mitundu yonse ya insulin ndi hypoglycemia. Milandu yayikulu, imatha kuyambitsa chikumbumtima, pokha pokha - imayambitsa imfa.

Nthawi zina thupi lanu siligwirizana: redness, kuyabwa, kapena kutupa pamalo a jakisoni. Monga lamulo, zochitika izi zimadalira palokha patatha masiku angapo / masabata. Mwa wodwala payekhapayekha, samagwirizanitsidwa ndi insulin, koma amayambitsidwa, mwachitsanzo, popanda kuyamwa kwa mankhwala kapena pakhungu pakatha kugwiritsa ntchito mankhwala oyeretsa.

Insulin nthawi zambiri imayambitsa zochitika zonse zamatsenga, koma zimakhala zazikulu kwambiri. Zizindikiro zotsatirazi zitha kuwoneka: kupuma movutikira, kupuma movutikira, kuchepa kwa magazi, tachycardia, kutuluka thukuta, pruritus. Ngati thupi lanu siligwirizana kwambiri, muyenera kuchitapo kanthu mwachangu. Odwala oterowo angafunike kufooka kwa mankhwala kapena kusintha kwa insulin.

Ndi chithandizo chotenga nthawi yayitali, lipodystrophy imatha kupezeka pamalo a jekeseni.

Milandu yapadera yokhudzana ndi chitukuko cha edema imadziwika, makamaka ndi kufalikira kwamisempha ya magazi motsutsana ndi maziko a insulin Therapy poyambira osakhutiritsa glycemic control.

Bongo

Ndi mankhwala osokoneza bongo ambiri a insulin, hypoglycemia imayamba, ikuphatikizidwa ndi khungu lotuwa, kuchuluka thukuta, kufoka, mutu, chisokonezo, kunjenjemera, tachycardia, ndi kusanza. Nthawi zina (mwachitsanzo, pakayang'aniridwa kwambiri kwa matenda a shuga kapena kutalika kwa matenda a shuga), Zizindikiro zakutsogolo za hypoglycemia zimatha kusintha.

Hypoglycemia nthawi zambiri imayimitsidwa ndi kumeza shuga kapena shuga. Monga zochizira, insulin, zakudya ndi / kapena zochitika zolimbitsa thupi zimakonzedwa.

Hypoglycemia wolimbitsa imakonzedwa ndi minyewa kapena subcutaneous makonzedwe a glucagon, ndiye kuti wodwalayo akulimbikitsidwa kudya pakamwa.

Hypoglycemia kwambiri imatha kuyambitsa matenda amitsempha, kukomoka, chikomokere. Odwala zotchulidwa intramuscular kapena subcutaneous makonzedwe a glucagon kapena mtsempha wa magazi makonzedwe a anakonza njira ya shuga (dextrose). Pofuna kupewa kukonzanso kwa hypoglycemia, pambuyo pobwezeretsa chikumbumtima, wodwalayo ayenera kudya chakudya chopatsa thanzi. Wodwala ayenera kuyang'aniridwa ndi dokotala.

Malangizo apadera

Posamutsa wodwala kupita ku mtundu wina wa insulin kapena mankhwala a insulin wokhala ndi dzina lina, kuyang'aniridwa mosamala kuchipatala kumafunika. Ngati mungasinthe mtundu (wopanga), mitundu (insulin ya nyama, analog ya anthu kapena yaumunthu), mtundu (sungunuka insulini, isophan insulin, ndi zina) ndi / kapena njira yokonzekera (DNA recombinant insulin kapena insulin ya nyama), kukonza kungafunike Mlingo.

Posamutsa wodwala kuchokera ku insulin yakuchokera kwa nyama kupita ku insulin yaumunthu, kusintha kosafunikira kungafunikire, kuwonjezera apo, pakumwa koyamba kwa mankhwala kapena pang'onopang'ono kwa milungu ingapo / miyezi ingapo.

Mikhalidwe ya Hypo-ndi hyperglycemic iyenera kuwongoleredwa, apo ayi imayambitsa kutha kwa chikumbumtima, chikomokere ngakhale kufa.Tiyenera kukumbukira kuti zizindikiro za zomwe zimayambira ku hypoglycemia zimatha kusintha, kuuma kwawo kungachepetse ndi njira yayitali ya matenda a shuga kapena matenda ashuga, komanso kugwiritsa ntchito munthawi yomweyo beta-blockers.

Mlingo wosakwanira komanso kufalikira kwa Humalog Mix 50, makamaka matenda a shuga 1, angayambitse matenda a hyperglycemia ndi matenda ashuga a ketoacidosis - zinthu zomwe zitha kuwonongera wodwala moyo.

Ndi matenda ena ndi kupsinjika kwamalingaliro, kufunikira kwa insulin kungakulitse.

Kusintha kwa mtundu wa Humalog Remix 50 kungafunike ngati kusintha kwa zakudya zabwinobwino kapena kuchuluka kwa zolimbitsa thupi. Kuchulukitsa zolimbitsa thupi nthawi zina kumawonjezera chiopsezo cha hypoglycemia.

Makatoni okhala ndi mankhwalawa ayenera kugwiritsidwa ntchito ndi zolembera zomwe zimakhala ndi chizindikiro cha CE.

Pofuna kupewa kufalitsa matenda opatsirana, munthu m'modzi yekha ayenera kugwiritsa ntchito cholembera kapena cholembera, ngakhale atasintha singano.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Ndi chitukuko cha hypoglycemia, kuchepa kwamphamvu kwa magwiridwe antchito ndi chidwi kwambiri ndizotheka, zomwe zimawonjezera chiopsezo chovulala mukamachita zinthu zoopsa, kuphatikizapo kuyendetsa galimoto komanso kugwira ntchito ndi magawo ena. Pankhaniyi, kusamala kuyenera kuchitika, makamaka kwa odwala omwe zizindikiro za okhazikika za hypoglycemia palibe kapena ofatsa. Pankhani yakukhazikika kwa hypoglycemia, kuthekera kochita zinthu zomwe zingachitike ndi zoopsa kuyenera kuyesedwa.

Mimba komanso kuyamwa

Maphunziro okwanira komanso owongoleredwa mosamalitsa mwa amayi apakati sanachitike. Poyeserera nyama, zovuta za chonde komanso zovuta zomwe zimachitika ndi mankhwala pa mwana wosabadwayo sizinapezeke. Komabe, zimadziwika kuti zotsatira zomwe zimapezeka chifukwa cha kafukufuku wamavuto amomwe zimachitika pakubala kwachinyama sizimafananizidwa nthawi zonse ndi zomwe zimachitika chifukwa cha mankhwalawa. Pamenepa, pa nthawi ya pakati Humalog Remix 50 ikhoza kugwiritsidwa ntchito pokhapokha ngati pali zifukwa zokwanira za kuchipatala.

Ngati kutenga pakati kumachitika panthawi ya chithandizo, muyenera kuchenjeza dokotala, chifukwa nthawi imeneyi ndikofunikira kuwunika momwe zinthu zilili komanso njira yothandizira. Mu trimester yoyamba, kufunika kwa insulin nthawi zambiri kumachepera, mu wachiwiri ndi wachitatu ma trimesters amachulukana. Nthawi yobadwa pambuyo komanso pobadwa, zofunika za insulini zimatha kuchepa kwambiri.

Nthawi yoyamwitsa, amayi omwe ali ndi matenda osokoneza bongo angafunikire kusintha kwa insulin ndi / kapena zakudya.

Ndi chiwindi ntchito

Pankhani ya kulephera kwa chiwindi, Humalog Remix 50 iyenera kugwiritsidwa ntchito mosamala, moyang'aniridwa ndi dokotala, chifukwa kufunika kwa insulin kumatha kuchepa chifukwa kuchepa kwa kuthekera kwa gluconeogeneis komanso kuchepa kwa insulin metabolism. Komabe, kulephera kwa chiwindi, kuwonjezeka kwa insulin kungatheke, komwe kumafunikira kuchuluka kwa mlingo.

Kuyanjana kwa mankhwala osokoneza bongo

Hypoglycemic zotsatira za Humalog Remix 50 zimachepetsa beta₂adrenergic agonists (mwachitsanzo terbutaline, salbutamol, rhytodrine), glucocorticosteroids, phenothiazine zotumphukira, thiazide diuretics, chithokomiro iodine, mkamwa kulera, nicotinic acid, diazoxide, chlorprotixene, isoniazid, danazole.

Hypoglycemic kanthu Humalog Mix 50 kumapangitsanso m'kamwa wothandizila hypoglycemic, mankhwala a sulfa mankhwala anabolic mankhwala, beta-blockers, angiotensin akatembenuka zoletsa enzyme (captopril, enalapril), angiotensin II cholandilira muzikangana, ena antidepressants (monoamine oxidase zoletsa), salicylates (mwachitsanzo, acetylsalicylic acid), tetracyclines ,Kukonzekera kwa ethanol ndi ethanol, octreotide, guanethidine, fenfluramine.

Pogwiritsa ntchito munthawi yomweyo mankhwala a gulu la thiazolidinedione, chiopsezo chowonjezeka cha edema ndi kulephera kwa mtima ndizotheka, makamaka kwa odwala omwe ali ndi matenda amtima komanso kupezeka kwa zinthu zomwe zingayambitse matenda osalephera a mtima.

Reserpine, clonidine, ndi beta-blockers amatha kufinya zizindikiro za hypoglycemia zomwe zimapangidwa ndi Humalog Remix 50.

Kuchita kwa Humalog Mix 50 ndi insulin ina kukonzekera sikunaphunzire.

Kuthekera kwa kugwiritsa ntchito mankhwala ena aliwonse pachipatala cha matenda ashuga kuyenera kuvomerezedwa ndi dokotala.

Analogues Humalog Mix 50 ndi NovoMiks 30 Penfill, NovoMiks 30 FleksPen, NovoMiks 50 FleksPen, NovoMiks 70 FleksPen, kapamba aspart NovoRapid Penfill, NovoRapid FleksPen, Lantus SoloSTAR, Tudzheo SoloSTAR, Apidra, Homolong 40, insulin detemir, insulin lispro, Rosinsulin, Homorap 40 ndi ena.

Mtengo wa Humalog Mix 50 m'masitolo ogulitsa mankhwala

Mtengo woyenera wa Humalog Mix 50 ndi ma ruble 1767-1998. kwa ma cholembera a 5 QuickPen 3

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo aboma. Kudzipatsa nokha mankhwala kuopsa!

Poyamba zinkakhala kuti kumatheka kumapangitsa thupi kukhala ndi mpweya wabwino. Komabe, izi zidatsutsidwa. Asayansi atsimikizira kuti ukamadzuka, munthu amazizira ubongo ndikusintha magwiridwe ake.

Munthu wophunzira sakhala wokonzeka kutenga matenda aubongo. Ntchito zaluso zimathandizira kuti pakhale ziwalo zina zowonjezera kulipirira odwala.

Matenda osowa kwambiri ndi matenda a Kuru. Oimira okha a fuko la Fore ku New Guinea amadwala naye. Wodwala amafa chifukwa cha kuseka. Amakhulupirira kuti chomwe chimayambitsa matendawa ndicho kudya ubongo wa munthu.

Malinga ndi asayansi ambiri, mavitamini zovuta ndizothandiza kwa anthu.

Kuphatikiza pa anthu, cholengedwa chimodzi chokha padziko lapansi - agalu, omwe ali ndi vuto la prostatitis. Awa ndi abwenzi athu okhulupilika kwambiri.

Kutentha kwambiri kwa thupi kudalembedwa ku Willie Jones (USA), yemwe adamulowetsa kuchipatala ndi kutentha kwa 46,5 ° C.

James Harrison wazaka 74 yemwe amakhala ku Australia amakhala wopereka magazi pafupifupi nthawi 1,000. Ali ndi mtundu wamagazi osafunikira, ma antibodies omwe amathandizira akhanda omwe ali ndi vuto lalikulu la magazi kukhala ndi moyo. Chifukwa chake, waku Australia adapulumutsa ana pafupifupi mamiliyoni awiri.

Pa moyo, munthu wamba amapanga miyala yocheperako yoposa awiri.

Chiwindi ndi chiwalo cholemera kwambiri m'thupi lathu. Kulemera kwake pafupifupi 1.5 kg.

Mafupa aanthu ndi olimba kwambiri kuposa konkriti.

Poyesera kuti wodwala atuluke, madokotala nthawi zambiri amapita kutali kwambiri. Ndiye, mwachitsanzo, Charles Jensen wina mzaka kuyambira 1954 mpaka 1994. adapulumuka ntchito zopitilira 900 neoplasm.

Ku UK kuli lamulo malinga ndi momwe dokotala wothandizira amatha kukanirana opaleshoni ngati atasuta kapena wonenepa kwambiri. Munthu ayenera kusiya zizolowezi zoipa, kenako, mwina, sangafunikire opaleshoni.

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Impso zathu zimatha kuyeretsa malita atatu a magazi mphindi imodzi.

Ngakhale mtima wa munthu sugunda, akhoza kukhalabe ndi moyo nthawi yayitali, monga asodzi aku Norweji a Jan Revsdal. “Galimoto” yake inaimilira kwa maola 4 asodzi atasowa ndikugona mu chisanu.

Chiwerengero cha antchito aku ofesi chakwera kwambiri. Izi ndizodziwika kwambiri m'mizinda yayikulu. Ntchito yamaofesi imakopa amuna ndi akazi.

Zotsatira za insulin: mungasinthe bwanji mankhwala osokoneza bongo

Kuti tichotse matenda a shuga m'mankhwala, ndimakonda kugwiritsa ntchito insulin analogues.

Popita nthawi, mankhwalawa akuchulukirachulukira pakati pa madokotala ndi odwala awo.

Izi zitha kufotokozedwanso:

• zokwanira bwino za insulini popanga mafakitale,
• mbiri yayikulu chitetezo,
• kugwiritsa ntchito mosavuta
• kutengera kulumikizira jakisoni wa mankhwala ndi chinsinsi chake cha mahomoni.

Pakapita kanthawi, odwala omwe ali ndi matenda a shuga 2 amakakamizidwa kuti asinthe mapiritsi ochepetsa shuga m'magazi kuti alowe jakisoni wa insulin. Chifukwa chake, funso loti musankhe mankhwalawa ndiwofunika kwambiri.

Zokhudza insulin yamakono

Pali zolephera zina pakugwiritsira ntchito insulin ya anthu, mwachitsanzo, kuyang'ana pang'onopang'ono (wodwala matenda ashuga ayenera kupereka jakisoni kwa mphindi 30 mpaka 40 asanadye) komanso nthawi yayitali kwambiri yogwira (mpaka maola 12), yomwe imakhala chinthu chofunikira pakuchedwa kuchepa kwa hypoglycemia.

Kumapeto kwa zaka zana zapitazi, kufunikira kwakakulitsa mapangidwe a insulin omwe sangakhale opanda zolakwa izi. Ma insulin omwe amagwira ntchito mwachidule adayamba kupangidwa ndi theka lalifupi kwambiri kuposa momwe angathere.

Izi zinawabweretsa pafupi ndi mphamvu za insulin yakunja, yomwe imatha kulumikizidwa pambuyo pa mphindi 4-5 mutalowa m'magazi.

Mitundu ya insulin yopanda chopanda kanthu imatha kukhala yofanana komanso yodziwikika bwino kuchokera ku mafuta osakanikirana ndipo osaputa hypoglycemia yausiku.

M'zaka zaposachedwa, pakhala kusintha kwakukulu mu pharmacology, chifukwa akuti:

• Kusintha kwa mayankho acidic kukhala ndale,
• kupeza insulin yaumunthu pogwiritsa ntchito tekinoloje ya DNA,
• kupanga kwa insulin mmalo wapamwamba kwambiri ndi mawonekedwe atsopano a pharmacological.

Ma insulin analogi amasintha nthawi ya zochita za munthu mahomoni kuti apereke njira yodziwika yolumikizira matupi a anthu odwala matenda ashuga.

Mankhwalawa amathandizira kuti athe kukwaniritsa bwino pakati pa zoopsa zothira m'magazi amwazi ndikwaniritsa glycemia yomwe mukufuna.

Zofananira zamakono za insulin malinga ndi nthawi yomwe zimachitika nthawi zambiri zimagawidwa:

1. ultrashort (Humalog, Apidra, Novorapid Penfill),
2. yayitali (Lantus, Levemir Penfill).

Kuphatikiza apo, pali mankhwala osakanikirana omwe amalowa m'malo mwake, omwe ali osakanikirana ndi mahashoni a ultrashort komanso ma nthawi yayitali mwanjira inayake: Penfill, Humalog mix 25.

Humalog (lispro)

Mu kapangidwe ka insulin iyi, malo a proline ndi lysine adasinthidwa. Kusiyana pakati pa mankhwalawa ndi insulin yaumunthu yamunthu ndi kuchepa kocheperako kwa mayanjano apakati. Poona izi, lispro imatha kumizidwa mwachangu kulowa m'magazi a munthu wodwala matenda ashuga.

Ngati muzibayira mankhwala omwe ali mgulu lomwelo komanso nthawi yomweyo, Humalog iperekanso msanga kwambiri 2 times mwachangu. Hormone iyi imachotsedwa mwachangu kwambiri ndipo patatha maola 4 kuyika kwake kumafika pachimake. Kukumana kwa insulin yaumunthu yosavuta kudzasungidwa mkati mwa maola 6.

Poyerekeza lyspro ndi insulin yocheperako, titha kunena kuti zakale zingalepheretse kupanga kwa shuga ndi chiwindi kwambiri.

Palinso mwayi wina wa mankhwala a Humalog - ndiwodziwikiratu ndipo ungayambitse kusintha kwa mankhwalawa muzakudya zopatsa thanzi. Amadziwika ndi kusowa kwa kusintha kwakanthawi kofikira kuchokera pakuwonjezeka kwa kuchuluka kwa zinthu.

Kugwiritsa ntchito insulin yosavuta yaumunthu, kutalika kwa ntchito yake kumasiyanasiyana kutengera mlingo. Ndi chifukwa ichi kuti nthawi yotalikirapo maola 6 mpaka 12 imayamba.

Ndi kuwonjezeka kwa mulingo wa insulin Humalog, kutalika kwa ntchito yake kumakhalabe pafupifupi pamlingo umodzi ndipo kudzakhala maola 5.

Pambuyo pake ndikuwonjezereka kwa mlingo wa lispro, chiopsezo cha kuchepa kwa hypoglycemia sichikula.

Aspart (Novorapid Penfill)

Mafuta a insulin amenewa angayerekezere bwino mayankho okwanira a insulin pakudya. Kutalika kwake kumapangitsa kuti pakhale zovuta pakati pa chakudya, zomwe zimapangitsa kuti pakhale gawo lathunthu pakulamulira shuga.

Ngati tifanizira zotsatira za mankhwalawa ndi ma insulin omwe ali ndi insulin wamba yodziwika bwino ya anthu, kuwonjezeka kwakukulu kwa kuwongolera kwa misempha ya shuga yaposachedwa.

Kuphatikiza mankhwala ndi Detemir ndi Aspart kumapereka mwayi:

• pafupifupi 100% imasintha mawonekedwe a tsiku lililonse la insulin,
• kusintha moyenera mulingo wa glycosylated hemoglobin,
• Amachepetsa mwayi wokhala ndi vuto la hypoglycemic,
• muchepetse matalikidwe ndi kuchuluka kwa magazi a anthu odwala matenda ashuga.

Ndizofunikira kudziwa kuti panthawi ya mankhwala omwe ali ndi basal-bolus insulin analogues, kuchuluka kwambiri kwa thupi kunatsika kwambiri kuposa nthawi yonse yowonera mwamphamvu.

Glulisin (Apidra)

Anulin ya insulin ya anthu ndi mankhwala owonetsa pang'onopang'ono.

Malinga ndi pharmacokinetic yake, mawonekedwe a pharmacodynamic ndi bioavailability, Glulisin ndi wofanana ndi Humalog.

Mu ntchito yake ya mitogenic ndi metabolic, timadzi tambiri timasiyana ndi insulin yosavuta ya munthu. Chifukwa cha izi, ndizotheka kugwiritsa ntchito nthawi yayitali, ndipo ndizotetezeka kwathunthu.

Monga lamulo, Apidra iyenera kugwiritsidwa ntchito kuphatikiza ndi:

1. insulin yayitali yaumunthu
2. basal insulin analogue.

Kuphatikiza apo, mankhwalawa amadziwika ndi kuyamba mwachangu pantchito komanso nthawi yofupikirapo kuposa mahomoni abwinobwino amunthu.

Zimathandizira odwala omwe ali ndi matenda ashuga kuwonetsa kusinthasintha kwakukulu pakugwiritsa ntchito ndi chakudya kuposa timadzi ta munthu.

Insulin imayamba kugwira ntchito yake atangoyambika, ndipo magazi a shuga amatsika patadutsa mphindi 10 mpaka Apidra atabayidwa jakisoni.

Popewa hypoglycemia mwa okalamba odwala, madokotala amalimbikitsa kuyambitsidwa kwa mankhwalawa mutangodya kapena nthawi yomweyo. Kutsika kwa mahomoni kumathandiza kupewa zomwe zimadziwika kuti "overlay", zomwe zimapangitsa kupewa hypoglycemia.

Glulisin imatha kukhala yothandiza kwa iwo onenepa kwambiri, chifukwa kugwiritsa ntchito sikumayambitsa kulemera kowonjezereka. Mankhwalawa amadziwika ndi kuyambika mofulumira kwa kuchuluka kwa ndende poyerekeza ndi mitundu ina ya mahomoni a nthawi zonse ndi a lispro.

Apidra ndi yabwino kwa madigiri osiyanasiyana onenepa kwambiri chifukwa chosinthasintha kwambiri. Mu kunenepa kwa mtundu wa visceral, kuchuluka kwa mankhwalawa kumatha kusintha, zimapangitsa kuti zikhale zovuta kwa prandial glycemic control.

Detemir (Levemir Penfill)

Levemir Penfill ndi analogue of insulin ya anthu. Ili ndi nthawi yogwira ntchito ndipo ilibe nsonga. Izi zimathandizira kuyang'anira basal glycemic masana, koma amagwiritsidwa ntchito kawiri.

Mothandizidwa ndi subcutaneally, Detemir amapanga zinthu zomwe zimalumikizana ndi serum albin mu madzi amkati. Pambuyo posamutsira kudzera khoma la capillary, insulin imamangirizanso ku albumin m'magazi.

Pokonzekera, ndi gawo laulere lokha lomwe likugwira ntchito mwachilengedwe. Chifukwa chake, kumangiriza kwa albin ndi kuwola kwake pang'onopang'ono kumapereka ntchito yayitali komanso yopanda pake.

Levemir Penfill insulin imagwira wodwala yemwe ali ndi matenda ashuga bwino ndikuyambiranso kufunikira kwake kwenikweni kwa insulin.Sipereka kugwedeza musanayambe makatani.

Glargin (Lantus)

Glargin insulin cholowa m'malo mwake imakhala yothamanga. Mankhwalawa amatha kukhala osalala komanso osungunuka pang'ono m'malo okhala acidic, ndipo m'malo osalowerera ndendende (pamafuta ochepa) samasungunuka bwino.

Atangokhala subcutaneous makonzedwe, Glargin amalowa mu kusayanjana ndi mapangidwe a microprecipitation, komwe ndikofunikira kuti amasulidwe enanso a mankhwalawa komanso kugawa kwawo kukhala ma cell a insulin komanso ma dimers.

Chifukwa cha kuyenda kosadukiza komanso kwapang'onopang'ono kwa Lantus kulowa m'magazi a wodwala yemwe ali ndi matenda ashuga, kufalikira kwake mu njira kumachitika mkati mwa maola 24. Izi zimapangitsa kuti jakisoni wa mankhwala a insulin azitha kamodzi kokha patsiku.

Tikakhala ndi zinc zochepa, tikamakulungika, timadzi tating'onoting'ono totchedwa Lantus insulin timene timatulutsa, timathandizanso kutalika kwa nthawi yake. Mtheradi zonse za mankhwalawa zimatsimikizira mawonekedwe ake osalala komanso opanda chiyembekezo.

Glargin amayamba kugwira ntchito atatha mphindi 60 atabaya jekeseni wa subcutaneous. Mphamvu yake m'magazi a wodwala imatha kuthandizidwa pambuyo pa maola 2-4 kuyambira nthawi yoyamba kumwa mankhwala.

Mosasamala nthawi yeniyeni ya jekeseni wa mankhwalawa (m'mawa kapena madzulo) ndi malo omwe jekeseni yapafupi (m'mimba, mkono, mwendo), nthawi yowonekera kwa thupi idzakhala:

• pafupifupi - maola 24
• pazambiri - maola 29.

Kusintha kwa insulin Glargin kumatha kufanana ndi mahomoni achilengedwe pakuyenda kwawo kwambiri, chifukwa mankhwalawa:

1. Moyenerera amathandizira kudya shuga ndi zotumphukira zotengera insulin (makamaka mafuta ndi minofu),
2. amalepheretsa gluconeogeneis (amachepetsa shuga).

Kuphatikiza apo, mankhwalawa amalepheretsa kuwonongeka kwa minofu ya adipose (lipolysis), kuwonongeka kwa mapuloteni (proteinolysis), pomwe amalimbikitsa kupanga minofu.

Kafukufuku wazamankhwala a Glargin's pharmacokinetics awonetsa kuti kugawa kosagwiritsa ntchito bwino kwa mankhwalawa kumapangitsa kuti pafupifupi 100% ikhale ndi fanizo loyambira la insulin ya insulin mkati mwa maola 24. Nthawi yomweyo, mwayi wokhala ndi machitidwe a hypoglycemic ndi kulumpha lakuthwa m'magazi a shuga amachepetsa kwambiri.

Kusakaniza kwa Humalog 25

Mankhwala awa ndi osakaniza omwe amakhala ndi:

• 75% yovala kuyimitsidwa kwa horpro ya mahomoni,
• 25% insulin Humalog.

Izi ndi mitundu ina ya insulin imaphatikizidwanso mogwirizana ndi njira yawo yotulutsira. Kutalika kwa mankhwalawa kumaperekedwa chifukwa cha kufalikira kwa mahomoni lyspro, zomwe zimapangitsa kubwereza kupanga kwapansi kwa mahomoni.

25% yotsala ya insulin lispro ndi chinthu chomwe chimakhala chowonekera nthawi yayitali, chomwe chimakhudza glycemia atatha kudya.

Ndizofunikira kudziwa kuti Humalog mu kapangidwe kazosakaniza zimakhudza thupi mwachangu kwambiri poyerekeza ndi mahomoni afupiafupi. Imapereka chiwongolero chomaliza cha glycemia ya postpradial chifukwa chake mbiri yake imakhala yolimba poyerekeza ndi insulin yochepa.

Ma insulin osakanikirana amalimbikitsidwa makamaka kwa anthu omwe ali ndi matenda a shuga a 2. Gululi limaphatikizapo odwala okalamba omwe, monga lamulo, amavutika ndi mavuto a kukumbukira. Ichi ndichifukwa chake kuyambitsa kwa mahomoni musanadye kapena atangomaliza kumene kumathandizira kwambiri kukonza moyo wa odwala.

Kafukufuku wokhudzana ndi thanzi la odwala matenda ashuga omwe ali pagulu kuyambira zaka 60 mpaka 80 pogwiritsa ntchito mankhwala osakanikirana a Humalog 25 adawonetsa kuti adakwanitsa kulipira zabwino za kagayidwe kazakudya.Mwanjira yovomerezeka ya mahomoni isanayambe komanso itatha kudya, madokotala amatha kulemera pang'ono komanso kuchepa kwambiri kwa hypoglycemia.

Kodi insulini yabwino ndi iti?

Ngati tingayerekeze ma pharmacokinetics a mankhwalawa omwe amawaganizira, ndiye kuti kupezeka kwawo ndi adotolo ndikulondola kwa matenda a shuga, onse oyamba ndi achiwiri. Kusiyana kwakukulu pakati pa ma insulin awa ndi kusowa kwa kuwonjezeka kwa thupi panthawi yamankhwala komanso kuchepa kwa chiwerengero cha kusintha kwamasiku usiku m'magazi.

Kuphatikiza apo, ndikofunikira kuzindikira kufunika kwa jakisoni imodzi masana, yomwe ili yabwino kwambiri kwa odwala.

Mwapamwamba kwambiri ndizothandiza kwa Glargin human insulin analogue kuphatikiza ndi metformin kwa odwala omwe ali ndi matenda a shuga a 2.

Kafukufuku akuwonetsa kuchepa kwakukulu kwa ma spikes ausiku mu ndende ya shuga. Izi zimathandizira modabwitsa tsiku lililonse glycemia.

Kuphatikiza kwa Lantus ndi mankhwala apakamwa kuti muchepetse shuga wamagazi kunaphunziridwa mwa odwala omwe sangathe kulipira shuga.

Afunika kupatsidwa Glargin posachedwa. Mankhwalawa atha kulimbikitsidwa kuti athandizidwe ndi dokotala endocrinologist ndi akatswiri onse.

Kulimbitsa kwambiri mankhwala ndi Lantus kumapangitsa kuti pakhale kusintha kwamtundu wa glycemic m'magulu onse a odwala matenda a shuga.

Ultrashort insulin Humalog ndi mawonekedwe ake - ndizabwino kugwiritsa ntchito shuga?

Nzosadabwitsa kuti matenda ashuga amatchedwa matenda a zaka zana lino. Kuchuluka kwa odwala omwe ali ndi vutoli kukukulira chaka chilichonse.

Ngakhale zomwe zimayambitsa matendawa ndizosiyana, chibadwidwe ndichofunika kwambiri. Pafupifupi 15% ya odwala onse amadwala matenda a shuga 1. Mankhwala amafunika jakisoni wa insulin.

Nthawi zambiri, zizindikiro za matenda amtundu 1 zimawonekera paubwana kapena kuubwana. Matendawa amadziwika ndi kukula kwake mwachangu. Ngati zinthu sizikutsatiridwa munthawi yake, zovuta zimatha kubweretsa kusokonekera kwa machitidwe amodzi payekha, kapena thupi lonse.

Kugawa insulin kungachitike pogwiritsa ntchito Humalog, fanizo la mankhwalawa. Mukamatsatira malangizo onse a dokotala, wodwalayo amakhala wodekha. Mankhwala ndi analogue a insulin ya anthu.

Pamaapangidwe ake, pakufunika DNA yofunikira. Ili ndi mawonekedwe - imayamba kuchita zinthu mwachangu (pasanathe mphindi 15). Komabe, kutalika kwa zochita sikupitirira 2-5 mawola atalandira mankhwalawa.

Chofunikira chachikulu

Mankhwalawa ndi njira yopanda maonekedwe, yopaka makatoni (1.5, 3 ml) kapena mabotolo (10 ml). Imaperekedwa kudzera m'mitsempha. Chithandizo chogwira mankhwalawa ndi insulin lispro, kuchepetsedwa ndi zina zowonjezera.

Zina zomwe zikuphatikiza ndi izi:

1. metacresol
2. glycerol
3. zinc oxide
4. sodium hydrogen phosphate,
5. 10% hydrochloric acid solution,
6. 10% sodium hydroxide solution,
7. madzi osungunuka.

Mankhwala akuphatikizidwa mu kayendedwe ka glucose, pochita zotsatira za anabolic.

Analogs ATC Level 3

Mankhwala opitilira atatu omwe ali ndi mawonekedwe osiyanasiyana, koma ofanana ndi mawonekedwe, njira yogwiritsira ntchito.

Mayina a ena ofanana ndi Humalog olembedwa ndi nambala 3 ya ATC:

• Biosulin N,
• Insuman Bazal,
• Protafan
• Humodar b100r,
• Gensulin N,
• Insugen-N (NPH),
• Protafan NM.

Kusintha kwa Humalog ndi Humalog 50: kusiyana

Ndikofunikira kudziwa! Mavuto omwe ali ndi kuchuluka kwa shuga pakapita nthawi imatha kudzetsa matenda ambiri, monga mavuto amaso, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba komanso matenda otupa! Anthu amaphunzitsa zomwe zinawawa kuti azisintha shuga yawo kuti asangalale ...

Ena odwala matenda ashuga molakwika amalingalira kuti mankhwalawo ndi othandizira kwathunthu. Izi siziri choncho. Prostamine Hagedorn (NPH) yosalowerera ndale, yomwe imachepetsa kuchitira insulin, imayambitsidwa mu Kusakaniza kwa Humalog 50.

Zowonjezera zowonjezera, nthawi yayitali ntchito. Kutchuka kwake pakati pa odwala matenda ashuga ndi chifukwa chakuti imathandizira njira yothandizira mankhwala a insulin.

Humalog Sakanizani ma cartridge 50 100 IU / ml, 3 ml mu syringe ya Quick Pen

Chiwerengero cha tsiku ndi tsiku cha jakisoni chimachepetsedwa, koma izi sizothandiza kwa odwala onse. Ndi jakisoni, nkovuta kupereka njira zabwino zowongolera shuga. Kuphatikiza apo, ndale ya protamine Hagedorn nthawi zambiri imayambitsa zovuta zomwe zimayambitsa matenda ashuga.

Kusakaniza kwa humalog 50 sikulimbikitsidwa kwa ana, odwala azaka zapakati. Izi zimawathandiza kupewa zovuta za matenda ashuga.

Nthawi zambiri, insulin yomwe imatenga nthawi yayitali imaperekedwa kwa odwala okalamba, omwe, chifukwa cha ukalamba, amayiwala kupanga jakisoni panthawi.

Humalog, Novorapid kapena Apidra - ndibwino?

Poyerekeza ndi insulin yaumunthu, mankhwalawo pamwambapa amalandiridwa mochita kupanga.

Mitundu yawo yosinthika imapangitsa kuti achepetse shuga mwachangu.

Insulin yaumunthu imayamba kuchita theka la ola, mankhwala ake omwe amafananizidwa ndi zotsatira zake amafunika mphindi 5-15 zokha. Humalog, Novorapid, Apidra ndi mankhwala a ultrashort omwe amapangidwa kuti achepetse shuga.

Mwa mankhwala onse, wamphamvu kwambiri ndi Humalog.. Imachepetsa shuga m'magazi 2,5 kuposeranso insulin yayifupi ya munthu.

Novorapid, Apidra ndiwofooka pang'ono. Ngati mungayerekeze mankhwalawa ndi insulin ya munthu, zimapezeka kuti zimakhala zamphamvu nthawi 1.5 kuposa zotsalazo.

Kupereka mankhwala enaake ochizira matenda a shuga ndi udindo wapadera wa dokotala. Wodwala amakumana ndi ntchito zina zomwe zingamulole kuthana ndi matendawa: kutsatira kwambiri zakudya, malangizo a dokotala, kukhazikitsa njira zotheka zolimbitsa thupi.

Pazakugwiritsa ntchito ka insulin Humalog mu kanema:

Insulin Humalog: momwe mungagwiritsire ntchito, kuchuluka kwake ndizovomerezeka komanso mtengo wake

Ngakhale kuti asayansi adakwanitsa kubwereza molekyulu yonse ya insulin, yomwe imapangidwa m'thupi la munthu, zochita za mahomoniwo zidasinthiratu chifukwa nthawi yomwe amafunika kunyamula magazi. Mankhwala oyamba osinthika anali insulin Humalog. Imayamba kugwira ntchito patangodutsa mphindi 15 jakisoni, choncho shuga yochokera m'mwaziyo imasamutsidwira minofu yake munthawi yake, ndipo ngakhale hyperglycemia yochepa siyimachitika.

Poyerekeza ndi ma insulins omwe adapangidwa kale, Humalog ikuwonetsa zotsatira zabwino: mwa odwala, kusinthasintha kwa shuga tsiku ndi tsiku kumachepetsedwa ndi 22%, mawonekedwe a glycemic amayenda bwino, makamaka masana, ndipo mwayi wa kuchepa kwambiri kwa hypoglycemia umachepa. Chifukwa chachangu, koma chokhazikika, insulin iyi imagwiritsidwa ntchito kwambiri mu shuga.

Moni Dzina langa ndine Galina ndipo sindilinso ndi matenda ashuga! Zinanditengera milungu itatu yokhakubwezeretsa shuga kwachikhalidwe komanso kusakhala mankhwala osokoneza bongo
>>Mutha kuwerenga nkhani yanga apa.

Malangizo achidule

Malangizo ogwiritsira ntchito insulin Humalog ndiwosakhazikika, ndipo magawo omwe amafotokoza zoyipa ndi mayendedwe akugwiritsidwa ntchito amakhala ndi zigawo zingapo.

Kufotokozera kwakutali komwe kumayendera limodzi ndimankhwala ena kumadziwika ndi odwala ngati chenjezo lokhuza kuwopsa kwawo.

M'malo mwake, zonse ndizofanana: langizo lalikulu, latsatanetsatane - umboni wa mayesero ambirikuti mankhwalawa adapirira.

Humalogue wavomerezedwa kuti agwiritse ntchito zaka 20 zapitazo, ndipo tsopano sizabwino kunena kuti insuliniyi ndi yotetezeka pa mlingo woyenera. Imavomerezedwa kuti agwiritsidwe ntchito ndi onse akulu ndi ana; itha kugwiritsidwa ntchito pazochitika zonse zomwe zimaphatikizidwa ndi kuperewera kwamahomoni akulu: mtundu 1 ndi matenda ashuga a 2, shuga ya gestational, ndi opaleshoni ya pancreatic.

Zambiri pa Humalogue:

Zina mwazotsatira zoyipa, hypoglycemia ndi thupi lawo siligwirizana nthawi zambiri zimawonedwa (1-10% ya odwala matenda ashuga). Osakwana 1% odwala amakhala ndi lipodystrophy pamalo opangira jekeseni. Makulidwe azinthu zina zoyipa amakhala ochepera 0.1%.

Chofunika Kwambiri Zokhudza Humalog

Kunyumba, Humalog imayendetsedwa pang'onopang'ono pogwiritsa ntchito cholembera kapena pampu ya insulin. Ngati matenda oopsa a hyperglycemia atachotsedwa, mankhwala osokoneza bongo amathandizanso kuchipatala. Pankhaniyi, kuthana ndi shuga pafupipafupi ndikofunikira kupewa bongo.

Chithandizo chogwira ntchito cha mankhwala ndi insulin lispro. Amasiyana ndi mahomoni amunthu pakupanga ma amino acid mu molekyulu. Kusintha koteroko sikulepheretsa ma cell receptors kuzindikira mahomoni, chifukwa chake amapatsira shuga mwa iwo okha.

Chiwonetserochi chimakhala ndi ma insulin monomers okha - mamolekyulu osalumikizana. Chifukwa cha izi, imakamizidwa mwachangu komanso moyenera, imayamba kuchepetsa shuga mwachangu kuposa insulin yachilendo.

Humalog ndi mankhwala ofupikitsika kuposa, mwachitsanzo, Humulin kapena Actrapid. Malinga ndi gulu, amatchulidwa ndi ma insulin omwe ali ndi ultrashort action.

Kuyamba kwa ntchito yake kumachitika mwachangu, pafupifupi mphindi 15, kotero odwala matenda ashuga sayenera kudikirira mpaka mankhwalawo atagwira, koma mutha kukonzekera chakudya mukangobaya jakisoni.

Chifukwa cha kufupika kwakanthawi, kumakhala kosavuta kukonza zakudya, ndipo chiopsezo cha kuiwala chakudya jakisoni itachepa.

Kuti muthane ndi vuto labwino la glycemic, insulin yothamanga iyenera kuphatikizidwa ndi kuvomerezedwa kwa insulin yayitali. Chokha chosiyana ndi kugwiritsa ntchito pampu ya insulin nthawi zonse.

Sankhani

Mlingo wa Humalog umatengera zinthu zambiri ndipo umatsimikiziridwa payekhapayekha kwa aliyense wodwala matenda ashuga. Kugwiritsa ntchito njira zoyenera sikulimbikitsidwa, popeza zimakulitsa kubwezeretsanso shuga.

Ngati wodwala amatsatira zakudya zamafuta ochepa, mlingo wa Humalog umakhala wocheperako kuposa momwe oyang'anira angapangire. Pankhaniyi, tikulimbikitsidwa kugwiritsa ntchito insulin yofulumira.

Ndikofunikira kwambiri: Lekani kudyetsa mafia azakudya nthawi zonse. Ma Endocrinologists amatipangitsa kuti tiziwonongeratu ndalama pamapiritsi pomwe shuga m'magazi amatha kukhala ngati ma ruble 147 ... >>werengani nkhani ya Alla Viktorovna

Hormashort ya Ultrashort imapereka mphamvu kwambiri. Mukasinthira ku Humalog, mlingo wake woyambirira amawerengedwa ngati 40% ya insulin yayifupi. Malinga ndi zotsatira za glycemia, mlingo umasinthidwa. Chofunikira pakukonzekera mkate uliwonse ndimagawo 1-1,5.

Ndondomeko ya jekeseni

Chakudya chimayalidwa chakudya chilichonse chisanachitike. osachepera katatu patsiku. Pankhani ya shuga wambiri, mawonekedwe okhathamira pakati pa jakisoni wamkulu amaloledwa. Malangizo ogwiritsira ntchito akutsimikizira kuwerengera kuchuluka kwa insulini yochokera pamafuta omwe akukonzekera chakudya chotsatira. Pafupifupi mphindi 15 ayenera kuchokera jakisoni kupita chakudya.

Malinga ndi ndemanga, nthawi ino nthawi zambiri zimakhala zochepa, makamaka masana, pomwe insulin kukana imakhala yotsika. Mlingo wa mayamwidwe ndi munthu payekhapayekha, umatha kuwerengeka pogwiritsa ntchito kuchuluka kwa shuga m'magazi pambuyo pobayidwa. Ngati kutsitsa kwa shuga kumawonedwa mwachangu kuposa momwe malangizowo amafunikira, nthawi yomwe chakudya chisanachitike iyenera kuchepetsedwa.

Humalog ndi imodzi mwamankhwala omwe amafulumira kwambiri, motero ndikosavuta kugwiritsa ntchito ngati thandizo ladzidzidzi la matenda ashuga ngati wodwala akuwopseza kuti ali ndi vuto la hyperglycemic.

Nthawi yogwira (yochepa kapena yayitali)

Peak ya insulin ya ultrashort imawonedwa patatha mphindi 60 kuchokera pakukhazikitsa. Kutalika kwa zochita zimatengera mlingo; kukula kwake ndikutalika kwa shuga, pafupifupi maola pafupifupi anayi.

Kusakaniza kwa Humalog 25

Kuti muwone molondola momwe Humalog ikuyendera, glucose amayenera kuyesedwa pambuyo pa nthawi imeneyi, nthawi zambiri izi zimachitidwa chakudya chotsatira chisanachitike. Miyeso yoyambirira imafunikira ngati hypoglycemia ikukayikira.

Kutalika kwakanthawi kwa Humalog si koyipa, koma mwayi wa mankhwalawa. Tikuthokoza, odwala omwe ali ndi matenda osokoneza bongo sakhala ndi vuto la hypoglycemia, makamaka usiku.

Zofanizira ndi mitengo

Fomu ya Mlingo:kuyimitsidwa koyenda

Machitidwe

Kusakaniza kwa lyspro insulin, kukonzekera insulin mwachangu komanso kuyimitsidwa kwa protamine kuyimitsa lyspro insulin, kukonzekera kwa insulini pakukonzekera.

Lyspro insulin ndi michere ya DNA yophatikizananso ndi insulin ya anthu; Imayendetsa kagayidwe ka glucose, imakhala ndi zotsatira za anabolic. Mumisempha ndi ena.

minofu (kupatula ubongo) imathandizira kusintha kwa glucose ndi ma amino acid m'chipinda, kumalimbikitsa kupangika kwa glycogen kuchokera ku glucose mu chiwindi, kutsutsana ndi gluconeogeneis ndikuthandizira kusintha kwa glucose ochulukirapo kukhala mafuta. Zofanana ndi insulin yaumunthu.

Poyerekeza ndi insulin yaumunthu wamba, imadziwika ndi kuyamba mwachangu, kuyambika koyambirira kwa kanthu komanso nthawi yayifupi ya hypoglycemic zochita (mpaka maola 5).

Kuyambanso mwachangu (mphindi 15 pambuyo pa kupangika) kumalumikizidwa ndi kuchuluka kwa mayamwidwe ndipo kumalola kuti liperekedwe nthawi yomweyo musanadye (kwa mphindi 15) - insulin yachibadwa yamunthu imaperekedwa kwa mphindi 30. Kusankha kwa jakisoni wambiri ndi zinthu zina kungakhudze kuchuluka kwa mayamwidwe ndi kuyamba kwake. Kuchuluka kwake kumawonedwa pakati pa maola 0.5 ndi 2,5, kutalika kwa nthawi ndi maola 3-4.

Zowonetsa:

Type 1 shuga mellitus, makamaka ndi tsankho la insulin, postprandial hyperglycemia, yomwe singathe kuwongoleredwa ndi ena.

insulini: pachimake subcutaneous insulin kukana (inapititsa patsogolo insulin kuwonongeka). Type 2 shuga mellitus - mu milandu kukana m`kamwa hypoglycemic mankhwala, kuyamwa kwa ena.

insulin, pa ntchito, matenda wamba.

Zoyipa:

Hypersensitivity, hypoglycemia, insulinoma.

Zotsatira zoyipa:

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kuchepa kwa magazi), lipodystrophy, zolakwika zosakhalitsa (nthawi zambiri mwa odwala omwe sanalandire insulin kale), hypoglycemia, hypoglycemic coma.

Zizindikiro: ulesi, thukuta, thukuta lotupa, tachycardia, kunjenjemera, njala, nkhawa, paresthesias mkamwa, kutsekemera kwa khungu, kupweteka mutu, kunjenjemera, kusanza, kugona, kugona tulo, mantha, kuthedwa nzeru, kukwiya, zachilendo, kusatsika koyenda, kusalankhula bwino ndi masomphenya, chisokonezo, chikomokere, kupweteka. Chithandizo: ngati wodwalayo akudziwa, adamulamula kuti adzipatsanso dextrose pakamwa, s / c, i / m kapena iv pobayira glucagon kapena iv hypertonic dextrose solution. Ndi chitupa cha hypoglycemic coma, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayamwa kudzera mu mtsempha kulowa kufikira wodwalayo atatuluka.

Mlingo ndi makonzedwe:

Mlingo umatsimikiziridwa payekha kutengera mulingo wa glycemia. Kusakaniza kwa 25% insulin lispro ndi 75% kuyimitsidwa kwa protamine kuyenera kuperekedwa kokha s / c, nthawi zambiri mphindi 15 musanadye.

Ngati ndi kotheka, mutha kulowa limodzi ndi insulin yokonzekera nthawi yayitali kapena ndi sulfonylureas pakamwa. Majakisoni amayenera kupangidwa m'ma s, mapewa, matako, matumbo.

Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Ndi s / c makonzedwe, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Odwala omwe ali ndi vuto laimpso komanso / kapena chiwindi, kuchuluka kwa insulin yozungulira kumakulitsidwa, ndipo kufunika kwake kumachepetsedwa, komwe kumafunikira kuwunika moyenera kuchuluka kwa glycemia ndi kusintha kwa insulin.

Malangizo apadera:

Njira yoyendetsera njira yomwe ikugwiritsidwa ntchito ikuyenera kuonedwa bwino. Posamutsa odwala kuchokera ku insulin yomwe ikuyenda mwachangu kuchokera ku insulin lispro, kusintha kwakufunikira kungafunike.

Kusamutsidwa kwa odwala omwe amalandira insulin tsiku lililonse mlingo wopitilira 100 kuchokera ku mtundu umodzi wa insulin kupita kwa ena ndikulimbikitsidwa kuti upangidwe mu chipatala.

Kufunika kwa insulin kumatha kuwonjezeka panthawi yomwe matenda opatsirana, ndi nkhawa zam'maganizo, ndi kuchuluka kwa chakudya chamagulu ambiri, pakudya kowonjezereka kwa mankhwala omwe ali ndi vuto la hyperglycemic (mahomoni a chithokomiro, GCS, kulera kwapakamwa, thiazide diuretics).

Kufunika kwa insulin kumatha kuchepa ndi kuchepa kwaimpso komanso / kapena chiwindi, ndi kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya, kuwonjezera kuchuluka kwa thupi, panthawi yowonjezera ya mankhwala omwe ali ndi vuto la hypoglycemic (Mao inhibitors, osasankha beta-blockers, sulfonamides).

Chizolowezi chokhala ndi hypoglycemia chitha kupangitsa kuti odwala azichita nawo mwachangu magalimoto, komanso kukonza makina ndi zida zina.

Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia mwa iwo kudzera pakudya shuga kapena zakudya zopatsa mphamvu zamafuta (tikulimbikitsidwa kuti nthawi zonse muzikhala ndi shuga osachepera 20 g). M'pofunika kudziwitsa adokotala za hypoglycemia yomwe yasamutsidwa kuti athetse vuto la kusintha kwa mankhwalawa. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndikuwonjezereka mu gawo lachiwiri mpaka lachitatu. Panthawi yobereka komanso pambuyo pawo, kufunika kwa insulin kumatha kuchepa kwambiri.

Insulin Lizpro, glycerol, metacresol, zinc oxide, sodium hydrogen phosphate heptahydrate, hydrochloric acid (sodium hydroxide solution), madzi.

Zizindikiro zogwiritsidwa ntchito

Insulin-wodwala matenda a shuga: kulekerera bwino kukonzekera insulin ina, postprandial hyperglycemiakukonza pang'ono ndi mankhwala ena, pachimake insulin kukana,

Matenda a shuga: pa milandu yokana mankhwala a antiidiabetes, machitidwe ndi matenda ochulukitsa chipatala cha odwala matenda ashuga.

Humalog, malangizo ogwiritsira ntchito

Mlingo wa mankhwalawa umayikidwa payekha kutengera mphamvu ya odwala exo native insulin ndi momwe alili. Ndikulimbikitsidwa kupatsa mankhwala osapitirira mphindi 15 musanadye kapena mutatha kudya. Njira yoyendetsera ntchito ndi payokha. Pochita izi, kutentha kwa mankhwala akhale pamalo oyenera.

Zofunikira zatsiku ndi tsiku zimatha zosiyanasiyana, mpaka nthawi zambiri zimakhala 0.5-1 IU / kg. Mtsogolomo, tsiku ndi tsiku Mlingo umodzi wa mankhwalawo umasinthidwa malinga ndi momwe wodwala amagwirira ntchito ndi zambiri kuchokera ku mayeso angapo a magazi ndi mkodzo wa glucose.

Intravenous management ya Humalog imachitika ngati muyezo wa jekeseni wovomerezeka. Jakisoni wotsekemera amapangidwa m'apewa, matako, ntchafu kapena pamimba, nthawi ndi nthawi kuwasinthana osaloleza kugwiritsa ntchito malo amodzimodzi kamodzi pamwezi, ndipo malo omwe jakisoniyo sayenera kutenthedwa. Pakati pa njirayi, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Wodwala ayenera kuphunzira njira yolondola ya jakisoni.

Kuchita

Hypoglycemic zotsatira za mankhwala amachepetsa kulera kwamlomo, Mankhwala Osokoneza bongo mahomoni a chithokomiro, GKS, Danazole, beta 2-adrenergic agonists, tridclic antidepressants, okodzetsa, Diazoxide, Isoniazid, Chlorprotixen, lithiamu carbonatezotumphukira phenothiazine, nicotinic acid.

Hypoglycemic zotsatira za mankhwalawa zimatheka anabolic steroids, opanga betamankhwala okhala ndi Mowa Fenfluramine, manzeru, Guanethidine, Mao zoletsa, m`kamwa hypoglycemic mankhwala, salicylates, sulfonamides, ACE zoletsa, Octreotide.

Humalog sikulimbikitsidwa kuti isakanikidwe ndi kukonzekera kwa insulin ya nyama, koma imatha kuyang'aniridwa ndikuyang'aniridwa ndi dokotala wokhala ndi insulin yayitali yaumunthu.

Mtengo wa Halogen, kuti mugule

Mtengo wa Humalog 100 IU / ml makatiriji 3 ml N5 amasiyana pamitundu yama ruble 1730-2086 pakiti iliyonse. Mutha kugula mankhwalawa m'masitolo ambiri ku Moscow ndi m'mizinda ina.

• Humalog Mix 25 kuyimitsidwa kwa 100 IU / ml 3 ml ma PC 5. Lilly Eli Lilly & Company
• Kuyimitsidwa kwa Humalog 100 IU / ml 3 ml ma PC 5. Lilly Eli Lilly & Company

• Humalog solution 100ME / ml 3ml No. 5 cartridge
• Humalog Mix 25 kuyimitsidwa kwa 100ME / ml 3ml No. 5 makatoni

Mankhwala IFK

• Insulin Humalog Lilly France S.A.S., France
• Insulin Humalog Remix 25 Lilly France S.A.S., France
• Insulin Humalog Lilly France S.A.S., France

LAPANI ZOTSATIRA! Zambiri pamankhwala omwe ali pamalowo ndizokhudza zonse, zomwe zimatengedwa kuchokera kwa anthu ndipo sizingagwiritsidwe ntchito ngati lingaliro la kugwiritsa ntchito mankhwalawa munthawi ya chithandizo.

Musanagwiritse ntchito mankhwala a Humalog, onetsetsani kuti mwawonana ndi dokotala.

Ma Analogi a Humalog

Lyspro insulin monga chinthu chogwira imangopezeka mu Humalog yoyambayo. Mankhwala osokoneza bongo ndi NovoRapid (kutengera aspart) ndi Apidra (glulisin).

Zida izi ndizoperewera -fupi, choncho zilibe kanthu kuti muzisankha iti. Zonse zimalekeredwa bwino ndipo zimapereka shuga msanga.

Monga lamulo, zokonda zimaperekedwa kwa mankhwalawa, omwe amatha kupezeka kwaulere kuchipatala.

Kusintha kuchokera ku Humalog kupita ku analogue yake kungakhale kofunikira pakakhala zovuta zina. Ngati wodwala matenda ashuga amatsatira zakudya zamafuta ochepa, kapena amakhala ndi hypoglycemia, ndizosavuta kugwiritsa ntchito anthu m'malo mwa insulin.

Chonde dziwani: Kodi mumalota kuti muthetse matenda ashuga kamodzi? Phunzirani momwe mungathetsere matendawa, osagwiritsa ntchito mankhwala okwera mtengo, pogwiritsa ntchito ... >> werengani zambiri apa

Mitundu ya Humalog Mix

Malangizo pazantchitoKusakaniza Kwa Humalog

Kutulutsa Fomu
kuyimitsidwa koyenda

Kupanga
1 ml ya kuyimitsidwa kuli: insulin lyspro 100 IU ndi osakaniza: insulin solution lispro 25% kuyimitsidwa kwa insulin lyspro protamine 75%

Othandizira: dibasic sodium phosphate, glycerol (glycerin), phenol yamadzi, metacresol, protamine sulfate, zinc oxide, d / I madzi, hydrochloric acid (10% yankho) ndi / kapena sodium hydroxide (10% yankho) (kukhazikitsa pH) .

Kulongedza
5 Senti yofulumira 3 mg uliwonse, makatoni 5 a 3 ml iliyonse.

Zotsatira za pharmacological
Humalog Mix ndi mankhwala osokoneza bongo a hypoglycemic, kuphatikiza kwa ma insulin analogi othamanga komanso apakati.

Humalog Mix 25 ndi DNA - maumboni okonzanso a insulin yaumunthu ndipo ndi chopangidwa chopangidwa chokonzekera chomwe chili ndi lyspro insulin yothetsera (analog yomwe ikugwira ntchito mwachangu insulin ya anthu) ndi kuyimitsidwa kwa lyspro protamine insulin (anthawi yapakati ya insulin analogue.

Chochita chachikulu cha insulin lyspro ndi malamulo a kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi.

Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Zinawonetsedwa kuti insulin lyspro ndiyofanana ndi insulin yaumunthu, koma machitidwe ake amakula mwachangu ndipo amakhalapo kwakanthawi kochepa. Kukhazikika kwa mankhwalawa kumatha pafupifupi mphindi 15, zomwe zimaloleza kuti ziziperekedwa nthawi yomweyo musanadye (0-15 mphindi musanadye), poyerekeza ndi insulin yaumunthu wamba.

Pambuyo pa jekeseni wa s / c wa Humalog Remix 25, kuyamba kwachangu ndi chiwopsezo choyambirira cha ntchito ya lyspro zimawonedwa. Mbiri ya insulin lysproprotamine imafanana ndi mbiri ya insulin isophan yotalika pafupifupi maola 15.

Humalog Remix 25, zikuwonetsa kugwiritsa ntchito
Matenda a shuga odwala matenda a insulin.

Contraindication
Hypoglycemia, hypersensitivity ku zigawo za mankhwala.

Mlingo ndi makonzedwe
Dokotalayo amawona mlingo payekhapayekha, kutengera kuchuluka kwa shuga m'magazi. Ndondomeko ya insulin makonzedwe ali payekha.

Mankhwala amayenera kuperekedwa s / c. Mu / pakukhazikitsa mankhwala a Humalog® Mix 25 ali ndi zotsutsana. Kutentha kwa mankhwalawa kuyenera kugwirizana ndi kutentha kwa chipinda. SC iyenera kuperekedwa kwa phewa, ntchafu, matako, kapena pamimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi.

Mukamayendetsa kukonzekera kwa Humalog® s / c, chisamaliro chimayenera kutetezedwa kuti mankhwalawo asalowe mumtsempha wamagazi. Pambuyo pakubaya, jakisoni wambiri, jekeseni sayenera kuchuluka.Kukakhazikitsa cartridge mu jakisoni wa insulin ndikupeza singano, malangizo a wopanga kuti ayende insulin

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimakhudzana ndi zotsatira zazikulu za mankhwalawa: nthawi zambiri - hypoglycemia. Hypoglycemia yamphamvu imatha kutha kwa chikumbumtima ndipo, mwapadera, amafa.

Zotsatira za mziwopsezo: Zotsatira zoyipa za m'deralo ndizotheka - kufupika, kutupa kapena kuyunkhira pamalo a jakisoni (nthawi zambiri zimatha patadutsa masiku angapo kapena masabata, nthawi zina, izi zimachitika chifukwa cha zifukwa zosagwirizana ndi insulin, mwachitsanzo, kupsa mtima pakhungu ndi jakisoni woletsa kapena jakisoni wosayenera ), zokhudza zonse ziwopsezo zimachitikira (zimachitika kawirikawiri, koma zimakhala zowopsa) - kuyabwa kambiri, kufupika, kupumira, kuchepa kwa magazi, tachycardia, kuchuluka thukuta. Milandu yayikulu yokhudzana ndi matupi awo amatsutsana omwe amatha kukhala osokoneza bongo. Pamafunika kusintha kwa insulin, kapena kufinya mtima.

Malangizo apadera
Kusamutsa wodwala kupita ku mtundu wina kapena kukonzekera kwa insulin ndi dzina lina lamalonda kuyenera kuchitika moyang'aniridwa ndi achipatala. Kusintha kwa zochitika, mtundu (wopanga), mtundu (mwachitsanzo, Wokhazikika, NPH), mitundu (nyama, munthu, insulin analogue) ndi / kapena njira yopanga (DNA recombinant insulin kapena insulin ya nyama) zitha kuthandizira kusintha kwa mlingo .

Kwa odwala ena, kusintha kwa mlingo kumakhala kofunikira pakusintha kuchokera ku insulin yochokera ku nyama kupita ku insulin ya anthu. Izi zitha kuchitika kale poyambilira kukonzekera kwa insulin ya anthu kapena pang'onopang'ono pakangotha ​​milungu ingapo kapena miyezi ingapo atasamutsidwa.

Zizindikiro zakutsogolo kwa hypoglycemia panthawi ya insulin yaumwini mwa odwala ena akhoza kutchulidwa kochepa kapena zosiyana ndi zomwe zimawonedwa ndi insulin ya nyama.

Ndi kusintha kwa matenda a shuga m'magazi, mwachitsanzo, chifukwa cha insulin yokwanira, zonse kapena zizindikiro zina zakutsogolo za hypoglycemia zitha kuzimiririka, zomwe odwala ayenera kudziwitsidwa.

Zizindikiro zakutsogolo kwa hypoglycemia zimatha kusintha kapena kusalankhula pang'ono ndi njira yayitali ya matenda a shuga, matenda ashuga a m'mimba kapena chithandizo cha mankhwala monga beta-blockers.

Mlingo wosakwanira kapena kuleka kwa chithandizo, makamaka kwa odwala omwe ali ndi matenda a shuga omwe amadalira odwala matenda a shuga, kungayambitse matenda a hyperglycemia ndi matenda ashuga ketoacidosis (mikhalidwe yomwe ikhoza kuwopseza moyo wa wodwalayo). .

Ndi matenda ena kapena kupsinjika kwamalingaliro, kufunikira kwa insulin kungakulitse. Kuwongolera mlingo wa insulin kungafunikenso ndi kuwonjezeka kwa zochitika zolimbitsa thupi kapena kusintha kwa zakudya zomwe mumakonda.

Kuyanjana kwa mankhwala osokoneza bongo
Mphamvu ya hypoglycemic ya mankhwala a Humalog Remix 25 imachepa ndi kugwiritsidwa ntchito mosiyanasiyana kwa mankhwalawa: kulera kwapakamwa, corticosteroids, kukonzekera kwa mahomoni a chithokomiro, danazole, beta2-adrenergic agonists (incl.ritodrin, salbutamol, terbutaline), thiazide okodzetsa, kukonzekera kwa lithiamu, chlorprotixen, diazoxide, isoniazid, nikotini acid, zotumphukira za phenothiazine.

Zotsatira za hypoglycemic za Humalog Remix 25 zimapangidwa ndi ophatikiza ndi beta, ma ethanol ndi mankhwala okhala ndi ethanol, mankhwala a anabolic, fenfluramine, guanethidine, tetracyclines, mankhwala a hypoglycemic acid, ma salicylates (mwachitsanzo, acetylsalicylic acid, zoletsa, ma captivitabeta, zoletsa) octreotide, angiotensin II receptor antagonists. Beta-blockers, clonidine, reserpine ikhoza kuphimba mawonetseredwe a zizindikiro za hypoglycemia. insulini sanaphunzire.

Bongo
Zizindikiro: hypoglycemia, limodzi ndi zizindikiro zotsatirazi - ulesi, kuchuluka thukuta, tachycardia, kupweteka mutu, kusanza, chisokonezo. Nthawi zina, mwachitsanzo, pakhale nthawi yayitali kapena kuwunika kwambiri matenda ashuga, Zizindikiro zakutsogolo za hypoglycemia zimatha kusintha.

Chithandizo: Matenda ofooketsa a hypoglycemia nthawi zambiri amayimitsidwa ndikuwonjezera shuga kapena shuga wina, kapena zinthu zokhala ndi shuga. Kusintha kwa mlingo wa insulin, zakudya, kapena zolimbitsa thupi kungafunike.

Kuwongolera kwa hypoglycemia moyenera kumatha kuchitika mothandizidwa ndi / m kapena s / c makonzedwe a glucagon, otsatiridwa ndi kumeza chakudya.

Miyezo yambiri ya hypoglycemia, yokhala ndi chikomokere, kukomoka kapena kuchepa kwa mitsempha, imayimitsidwa mkati / m kapena s / kukhazikitsidwa kwa glugagon kapena iv mwa kuyambitsa kwa yankho la yankho la dextrose (glucose).

Pambuyo pozindikira, wodwalayo ayenera kupatsidwa chakudya chopatsa thanzi kuti ateteze kukonzanso kwa hypoglycemia. kuyambiranso kwa hypoglycemia ndikotheka.

Malo osungira
Pamalo amdima pakutentha kwa 2-8 ° C.

Tsiku lotha ntchito
Zaka 2

Makhalidwe ndi malangizo ogwiritsira ntchito insulin Humalog

Mwa zina mwa mankhwala omwe amapezeka ndi insulin ambiri amatha kutchedwa Humalog. Mankhwala akupangidwa ku Switzerland.

Zimakhazikitsidwa ndi insulin Lizpro ndipo cholinga chake ndikuchizira matenda ashuga.

Mankhwala ayenera kuikidwa ndi dokotala. Ayeneranso kufotokozera malamulo omwera mankhwalawo kuti mupewe mavuto. Mankhwalawa amagulitsidwa kokha ndi mankhwala.

Humalog ili mu mawonekedwe a kuyimitsidwa kapena jakisoni. Kuyimitsidwa kumakhala koyera komanso kutengera kupangika. Njira yothetsera vutoli ndi yopanda utoto komanso wopanda fungo, yowonekera.

Chofunikira kwambiri pakuphatikizidwa ndi Lizpro insulin.

Kuphatikiza apo, zosakaniza monga:

• madzi
• metacresol
• zinc oxide
• glycerol
• sodium hydrogen phosphate heptahydrate,
• sodium hydroxide solution.

Chogulitsachi chimagulitsidwa m'mak cartridge atatu. Makatoni ali mu cholembera cha Quickpen, zidutswa 5 pa paketi imodzi.

Komanso pali mitundu ya mankhwalawa, yomwe imaphatikizapo yankho la insulin yochepa komanso kuyimitsidwa kwa protamine. Amadziwika kuti Humalog Remix 25 ndi Humalog Remix 50.

Lizpro insulin ndi mawonekedwe a insulin yaumunthu ndipo amadziwika ndi zomwezi. Zimathandizira kukulitsa kuchuluka kwa shuga. Pulogalamu yogwira imagwira pama cell membrane, chifukwa choti shuga kuchokera m'magazi amalowa m'matumbo ndipo amawagawa. Zimathandizanso kupanga mapuloteni omwe amagwira ntchito.

Mankhwala amadziwika ndi kuchitapo kanthu mwachangu. Zotsatira zimawonekera mkati mwa kotala la ola mutatha jakisoni. Koma imapitilira kwakanthawi. Hafu ya moyo wa zinthu zimafunika pafupifupi 2 hours. Nthawi yowonetsera kwambiri ndi maola 5, omwe amathandizidwa ndi mawonekedwe a thupi la wodwalayo.

Zizindikiro ndi contraindication

Chizindikiro chogwiritsira ntchito mankhwala omwe ali ndi insulin ndi:

Muzochitika izi, mankhwala a insulin amafunikira. Koma Humalog iyenera kusankhidwa ndi adotolo atatha kuphunzira chithunzi cha matendawa. Mankhwalawa ali ndi zotsutsana zina. Muyenera kuwonetsetsa kuti kulibe, apo ayi pamakhala zovuta za zovuta.

Izi zikuphatikiza:

• kupezeka kwa hypoglycemia (kapena kupezeka kwake),
• ziwengo kuti zikuchokera.

Ndi izi, adotolo ayenera kusankha mtundu wina wa mankhwala. Kusamala ndikofunikanso ngati wodwala ali ndi matenda ena owonjezereka (matenda a chiwindi ndi impso), chifukwa chifukwa cha iwo, kufunikira kwa insulin kumatha kufooka. Chifukwa chake, odwala otere ayenera kusintha mlingo wa mankhwalawa.

Odwala Apadera ndi Mayendedwe

Mukamagwiritsa ntchito Humalog, kusamala kwina kumafunikira pokhudzana ndi magulu apadera a odwala. Matupi awo amatha kukhala osamala kwambiri ndi zovuta za insulin, motero muyenera kukhala anzeru.

Zina mwa izo ndi:

1. Amayi pa nthawi yoyembekezera. Mwachidziwitso, chithandizo cha matenda a shuga mwa odwala amaloledwa. Malinga ndi zotsatira za kafukufuku, mankhwalawa samavulaza kukula kwa mwana wosabadwayo ndipo samayambitsa mimbayo. Koma ziyenera kukumbukiridwa kuti munthawi imeneyi kuchuluka kwa shuga m'magazi kumatha kukhala kosiyana panthawi zosiyanasiyana. Izi ziyenera kuyang'aniridwa kuti mupewe zotsatira zoyipa.
2. Amayi oyamwitsa. Kulowetsedwa kwa insulin mkaka wa m'mawere sikowopsa kwa akhanda. Izi zimachokera kumapuloteni ndipo zimatengedwa m'matumbo a mwana. Chenjezo lokha ndiloti azimayi omwe amadyetsa mwachilengedwe ayenera kudya.

Kwa ana ndi okalamba posakhala ndi mavuto azaumoyo, chisamaliro chapadera sichofunikira. Humalog ndi yoyenera chithandizo chawo, ndipo adotolo ayenera kusankha kuchuluka kwa mankhwalawa kutengera mawonekedwe a matendawa.

Kugwiritsa ntchito Humalog kumafunikira kukonzekereratu poyerekeza ndi matenda ena oyipa.

Izi zikuphatikiza:

1. Kuphwanya chiwindi. Ngati chiwalochi chikugwira ntchito moyipa kuposa momwe chikufunikira, ndiye kuti mankhwalawo atha kukhala ochulukirapo, zomwe zimabweretsa zovuta, komanso kukula kwa hypoglycemia. Chifukwa chake, pakakhala kulephera kwa chiwindi, mlingo wa Humalog uyenera kuchepetsedwa.
2. Mavuto a impso. Ngati alipo, palinso kuchepa kwa kufunika kwa insulin. Pankhaniyi, muyenera kuwerengera mosamala ndi kuyang'anira njira yochiritsira. Kukhalapo kwa vuto lotere kumafuna kupenda kwakanthawi.

Humalog imatha kuyambitsa hypoglycemia, chifukwa chomwe kuthamanga kwazomwe zimachitika komanso kuthekera kwazomwe zimayang'ana zimasokonezedwa.

Chizungulire, kufooka, kusokonezeka - zinthu zonsezi zimatha kugwira ntchito kwa wodwala. Zochita zomwe zimafunikira kuthamanga komanso kusokonezedwa zimatha kukhala zosatheka kwa iye. Koma mankhwalawo pawokha samakhudza izi.

Mtengo, ndemanga ndi fanizo la mankhwala

Mankhwalawa amagulitsidwa kokha ndi mankhwala. Itha kugulidwa ku pharmacy wamba kapena pa intaneti. Mtengo wa mankhwala ochokera ku mtundu wa Humalog siwokwera kwambiri, aliyense amene ali ndi ndalama zambiri amatha kugula. Mtengo wazokonzekera ndi wa Humalog Remix 25 (3 ml, 5 pcs) - kuyambira 1790 mpaka 2050 rubles, ndi Humalog Remix 50 (3 ml, 5 pcs) - kuyambira 1890 mpaka 2100 rubles.

Ndemanga ya anthu ambiri odwala matenda ashuga okhudza insulin Humalog yabwino. Pali ndemanga zambiri pa intaneti ponena za kugwiritsa ntchito mankhwalawa, omwe amati ndizosavuta kugwiritsa ntchito, ndipo amachita mwachangu mokwanira.

Zotsatira zoyipa ndizosowa kwambiri. Mtengo wa mankhwalawa si "kuluma" kwambiri, monga amanenera ndi odwala matenda ashuga. Insulin Humalog imagwira bwino ntchito ndi shuga wambiri.

Kuphatikiza apo, maubwino otsatirawa a mankhwala ochokera munthawiyi amatha kusiyanitsidwa:

• kusintha kagayidwe kazakudya,
• kutsika kwa HbA1,
• Kuchepetsa matenda a glycemic usana ndi usiku,
• luso logwiritsa ntchito zakudya zosinthika,
• kugwiritsa ntchito mankhwala mosavuta.

Ngati wodwala aletsedwa kugwiritsa ntchito mankhwalawo kuchokera ku mtundu wa Humalog, adotolo atha kupereka mankhwala ena mwachitsanzo:

1. Isofan
2. Iletin
3. Pensulin,
4. Depot insulin C,
5. Insulin humulin,
6. Rinsulin
7. Actrapid MS ndi ena.

Mankhwala achikhalidwe amasinthasintha, kupanga ndi kukonza mankhwala omwe amathandiza anthu ambiri kukhala ndi moyo komanso thanzi.

Pogwiritsa ntchito moyenera mankhwala a insulin kuchokera ku mankhwalawa a Humalog, mutha kuchotseratu zovuta za hypoglycemia ndi zizindikiro za "matenda okoma". Muyenera kutsatira malangizo a dokotala anu ndipo musamayeserere.

Pokhapokha ngati munthu akudwala matenda ashuga amatha kutha kuwongolera matendawa ndikukhala mokwanira limodzi ndi anthu athanzi.

Kanemayo m'nkhaniyi afotokoza za mankhwala omwe amapezeka mu insulin Humalog.

Sonyezani shuga yanu kapena sankhani jenda kuti muyimikize.