Lipantil mankhwala: malangizo ntchito

mu chithuza 10 ma PC., mumapaketi okhala ndi makatoni 3 matumba.

Mankhwala

Ochepetsa triglycerides ndipo, pang'ono, cholesterol m'magazi. Zimathandizira kuchepetsa zomwe zili mu VLDL, mpaka zochepa - LDL, kuwonjezera zomwe zili anti-atherogenic HDL. Imayambitsa lipoprotein lipase ndipo, motero, imakhudza kagayidwe ka triglycerides, imasokoneza kaphatikizidwe wamafuta acid ndi cholesterol, ndikuthandizira kukulitsa kuchuluka kwa zolandilira za LDL m'chiwindi. Fenofibrate imachepetsa kuphatikiza kwa maselo am'magazi, imachepetsa kuchuluka kwa plasma fibrinogen, imatha kuchepetsa pang'ono shuga wa magazi mwa odwala omwe ali ndi matenda osokoneza bongo, komanso amachepetsa kuchuluka kwa uric acid m'magazi.

Pharmacokinetics

Metabolite yayikulu ndi fenofibroic acid. Pambuyo kumwa mankhwalawo mkati C_max mu plasma imatheka pambuyo maola 5. Mukamamwa mlingo wa 200 mg, pafupifupi plasma ndende ndi 15 μg / ml. Kuphatikizika kwa plasma kwa mankhwala ndikukhazikika. T_1/2 fenofibroic acid - pafupifupi maola 20. Amapukusidwa makamaka mkodzo (fenofibroic acid ndi glucuronide wake) atatha masiku 6. Siziunjikira pakumwa mlingo umodzi ndikugwiritsa ntchito nthawi yayitali. Fenofibroic acid samachotsedwanso pa hemodialysis.

Contraindication

Kusokonekera kwambiri kwa chiwindi ndi impso, mbiri ya kusintha kwa zithunzi kapena zojambula pakasinthidwe ka mankhwala a fenofibrate kapena mankhwala ena ofanana.

Zotsatira zoyipa

Diffuse myalgia, kupweteka kwa minofu, kufooka, komanso (kawirikawiri) rhabdomyolysis, nthawi zina kwambiri. Mankhwala akasiya, zinthu izi zimatha kusintha.

Kuchokera m'mimba: dyspepsia. Kuchulukitsa kwa hepatic transaminases mu seramu.

Zotsatira zoyipa: kawirikawiri - zotupa pakhungu, kuyabwa, urticaria, photosensitivity. Nthawi zina (atatha kugwiritsa ntchito miyezi ingapo), mawonekedwe a photosensitivity amatha kukhala ngati erythema, papules, vesicles, kapena eczematous totupa.

Kuchita

Kuphatikiza komwe kumatsutsana: ndi michere ina, chiwopsezo chowonjezereka cha zoyipa (kuwonongeka kwa minofu).

Kuphatikiza kosayenera: ndi HMG-CoA reductase inhibitors - chiwopsezo chowonjezereka cha zoyipa (kuwonongeka kwa minofu).

Kuphatikiza kugwiritsidwa ntchito mosamala - ndi anticoagulants osadziwika (chiwopsezo cha kutaya magazi). Kuwongolera pafupipafupi kwa PV ndikofunikira pakusankha kwa mlingo wa anticoagulant wosagwiritsidwa ntchito pochiza ndi michere ndipo mkati mwa masiku 8 atachoka.

Fenofibrate sagwiritsidwa ntchito molumikizana ndi Mao inhibitors.

Njira zopewera kupewa ngozi

Pali malipoti a momwe michere imakhudzira minofu ya minofu, kuphatikizapo milandu yachilendo ya necrosis. Njira izi nthawi zambiri zimachitika ndi kuchepa kwa plasma albin. Zomwe akuwonetsa ziyenera kukumbukiridwa mwa onse omwe ali ndi vuto la myalgia, ndikumva kuwawa kwa minofu komanso kuwonjezeka kwakukulu kwa mlingo wa creatine phosphokinase (5 times apamwamba kuposa abwinobwino). Muzochitika izi, chithandizo chikuyenera kusiyidwa.

Kuphatikiza apo, chiopsezo cha kuwonongeka kwa minofu chitha kuwonjezeka ngati mankhwalawo adapangidwa ndi HMG-CoA reductase inhibitors.

Chifukwa cha kupezeka kwa lactose, mankhwalawa amadziwikiridwa mu chibadwa cha galactosemia, vuto la glucose ndi galactose malabsorption kapena kuperewera kwa lactase.

Ngati kuchepa kokhutiritsa kwa ma seramu lipids sikunapezeke panthawi yomwe munagwiritsa ntchito mankhwalawa kwa miyezi 3-6, njira ina yothandizira odwala iyenera kuperekedwa.

Kuwunikira mwadongosolo kwa kuchuluka kwa hepatic transaminases mu seramu iliyonse ya 3 miyezi yoyamba 12 ya chithandizo ndikofunikira. Ngati mulingo wa AST ndi ALT ukuwonjezeka nthawi zopitilira 3 poyerekeza ndi VGN, chithandizo chikuyenera kutha.

Akaphatikizidwa ndi anticoagulants osawerengeka, kuwunika mosamala kayendedwe ka magazi ndikofunikira.

Zotsatira za pharmacological

Hypolipidemic wothandizira, ali ndi uricosuric ndi antiplatelet. Amachepetsa cholesterol yonse ya magazi ndi 20-25%, magazi a TG ndi 40-45% ndi uricemia ndi 25%. Ndi chithandizo chokwanira chotheka, madongosolo a cholesterol owonjezera amachepetsedwa.

Amachepetsa ndende ya TG, VLDL, LDL (mpaka pang'ono), imawonjezeka - HDL, imasokoneza kaphatikizidwe ka mafuta acids. Amachepetsa kuphatikiza kwa maselo a m'magazi, amachepetsa kuchuluka kwa plasma fibrinogen. Odwala omwe ali ndi matenda ashuga ali ndi vuto lotsegula kwambiri.

Malangizo apadera

Chithandizo chikuyenera kuchitika limodzi ndi zakudya zama cholesterol ndikuyang'aniridwa ndi dokotala.

Pokhapokha ngati pali njira yokhutiritsa pambuyo pa miyezi 3-6 yoyang'anira, concomitant kapena njira zina zitha kutumikiridwa.

Ndikulimbikitsidwa kuyang'anira ntchito ya "hepatic" transaminases miyezi itatu iliyonse mchaka choyamba chothandizira, kupuma kwakanthawi ngati chithandizo chawo chikuwonjezeka, komanso kupatulidwa munthawi yomweyo chithandizo cha mankhwala a hepatotoxic.

Mawonekedwe ndi kipimo

Mankhwala a Lipantil 200 m ali m'gulu la mankhwala opangidwa ndi fibroic acid. Chofunikira chachikulu pakupanga ndi fenofibrate. Imagwira pa PPA-α receptors, yambitsa zochita za lipoprotein lipase. Njirayi imathandizira njira yogawa mafuta ndikuchotsa tinthu tokhala m'magazi. Chifukwa chake, mulingo wa lipoproteins wotsika kwambiri umachepetsedwa mosadziwika, ndipo kuchuluka kwa lipoproteins okwera kwambiri, mosiyana, kumawonjezeka. Filrate komanso mopanda kutsika magazi. Mankhwalawa amathandizira kuchepetsa kuchuluka kwa fibrinogen, kupewa mapangidwe a magazi.

Kutulutsa kwa Lipantil ndi kaphokoso kolimba ka khungu la brownatin kokhala ndi ufa woyera mkati. Mankhwalawa amapezeka mu mlingo wa 200 mg, 30 zidutswa pa paketi iliyonse. Dziko loyambira - France. Mutha kugula mankhwalawa pokhapokha ngati mukumvera.

Zizindikiro zogwiritsidwa ntchito

Cholesterol chokwezeka cha digiri yoyamba ndi yachiwiri malinga ndi Fredrickson ndiye chisonyezo chachikulu chakuyika Lipantil. Ndi hyperlipidemia yophatikizika, tikulimbikitsidwa kuphatikiza mapiritsi a Lipantil mu njira ya achire. Ma triglycerides okwera amafunikiranso fenofibrate. Progressive atherosclerosis imawonjezera chiopsezo cha myocardial infarction ndi stroke. Pankhaniyi, kupewa, madokotala amalimbikitsa Lipantil.

Ndi kusalolera kwa mankhwala ena a hypolipidemic, mwachitsanzo, ma statins, kugwiritsa ntchito fenofibrate monga njira ina kukuwonekera.

Zotsatira zoyipa

Nthawi zambiri, odwala amadandaula za kutaya zakudya. Nthawi zina kupweteka kwa minofu kumatha kuchitika, choipitsitsa, kuwonongeka kwa minofu minofu. Hypersensitivity zochita pazigawo za Lipantil zimapezekanso. Kuphwanya ndi kuyabwa kungaoneke. Monga mankhwala ambiri ochepetsa lipid, fenofibrate imakulitsa kuchuluka kwa michere ya chiwindi m'magazi. Mapeto a maphunzirowa atatha, mavuto ambiri amawonongeka popanda kufufuza.

Nthawi zina mankhwalawa amayamba kuchuluka kwa mankhwala osokoneza bongo.

Mlingo ndi makonzedwe

Mlingo woyenera kwambiri ungasankhidwe ndi dokotala, mutaganizira mbiri yanu yazachipatala. Mlingo wokhazikika ndi 200 mg ya mankhwala patsiku. Pakuganiza kwa dokotala, nthawi zina mlingo wa tsiku ndi tsiku umagawika patatu. Kapisolo amatengedwa ndi chakudya, kutsukidwa ndi madzi. M'matenda akulu, kufunikira kwa tsiku ndi tsiku kwa mankhwala kumatha kufika mpaka 400 mg. Pankhaniyi, wodwalayo ali m'manja mwa ogwirira ntchito azachipatala.

Zolemba zogwiritsira ntchito

Osagwiritsa ntchito mankhwala opangira malabsorption a shuga, galactose. Mukapereka mankhwala a fibroic acid, ndikofunikira kuwunika mwadongosolo kuchuluka kwa chiwindi. Zomwe zimayambitsa magazi zimayang'aniridwa kosatha. Palibe chifukwa chomwe michere ndi mowa zingaphatikizidwe. Kuphatikiza koteroko kumatha kukhala ndi vuto lalikulu m'maselo a chiwindi, nthawi yoyipitsitsa, komanso zotsatira zosasintha.

Pa mimba ndi mkaka wa m`mawere

Nthawi ya mimba imapatula kugwiritsa ntchito mankhwalawa. Kwenikweni, monga kuyamwitsa. Popeza kudzera mkaka wa m'mawere, mankhwalawa amatha kusokoneza mwana.

Palibe zowerengeka zokhudzana ndi momwe mankhwala opangira mankhwala amapangira thupi la ana. Pankhaniyi, imaphatikizidwa mwa ana.

Mtengo wa mankhwala

Fenofibrate, dzina lamalonda Lipantil 200 M, ku Ukraine zitha kugulidwa pamtengo pafupifupi 520 UAH pamapiritsi 30. M'mafakitoreti a Russian Federation, mankhwalawa angakutayireni ma ruble 920 a phukusi lofanana. Musaiwale kuwonetsa dokotala wanu mankhwala kuchokera kwa dokotala musanagule. Onetsetsani kuti mankhwalawo atha.

Analogs Lipantil

Ngati mulingo wa Lipantil ndiwokwera kwambiri kwa wodwala, mmalo mwake mumakhala zotsalira za fibrate. Mwachitsanzo, Tricor, yemwe amapangidwa muyezo wa 145 mg piritsi limodzi pamtengo womwewo ndi Lipantil. Otsatsa ena ochulukirapo amaphatikizapo Fenofibrat Canon, opangidwa ndi Russia, ndi Exlip, Turkey. Dokotala wanu yekha ndi amene angakuthandizeni kuti mumvetsetse zochuluka za ma cellacological othandizira motsutsana ndi cholesterol. Osangotsogozedwa ndi chidziwitso chokha kuchokera pa intaneti.

Kugwiritsa Ntchito

Zomwe madokotala anena zokhudzana ndi mankhwalawa ndizodziwikiratu - zotsatira zabwino zilipo. M'mwezi woyamba wamankhwala, ndikotheka kuwunika zotsatira zoyambirira ndipo, ngati kuli kotheka, sinthani mlingo. Lipantil itha kugwiritsidwa ntchito ngati monotherapy, kapena kuphatikiza ndi mankhwala ena.

Odwala amakhudzidwa kwambiri ndi zotsatira za mankhwalawa pachiwindi. Koma kuchepetsa kolesterol kwathunthu kumakwanira chifukwa cha zovuta. Anthu ambiri amawona kuti zoyipa zomwe zimachitika pakumwa mapiritsi zimatha kuwongoleredwa ndikuchotsedwa. Ndipo zachidziwikire, mtengo sioyenera aliyense. Komabe, ambiri amavomereza kuti chinthu choyenera komanso chololedwa ndichofunika ndalama.

Mlingo

Mmodzi kapisozi muli

yogwira mankhwala - micenized fenofibrate 200 mg,

zotuluka: lactose, sodium lauryl sulfate, pregelatinized wowuma, crospovidone, magnesium stearate,

chipolopolo cha kapisozi: titanium dioxide (E 171), Iron (III) okusayidi wachikasu E172, Iron (III) oxide ofiira E172, gelatin.

Makapisozi Opaque kuwala bulauni No. 1. Zomwe zili m'mabotolo ndizoyera kapena pafupifupi ufa wabwino

Kugwiritsa ntchito mankhwala osokoneza bongo kwambiri

Muzochita zamankhwala, zoterezi ndizosowa kwambiri. Mankhwala osokoneza bongo a Lipantil amawonetsedwa ndi kuwodzera, chisokonezo, chizungulire, kukhumudwa kwina. Kupukusa kwa m'mimba kumafunika, kutsatiridwa ndi kukhudzidwa kwa enterosorbent iliyonse - kukonzedwa kaboni, Smecta, Enterosgel. Ndikofunikira kufunafuna chithandizo chamankhwala posachedwa ndi chodwala.

Mphamvu ya hypoglycemic ya mankhwala omwe amapezeka ndi sulfonylurea imatheka chifukwa chogwiritsa ntchito munthawi yomweyo ndi Lipantil. Zimathandizanso kuchulukitsa kochiritsira kwa ma coagulants osadziwika, omwe sikuti nthawi zonse amalangizidwa. Kuphatikiza kwa cyclosporine ndi lipid-kutsitsa kungapangitse kuchepa kwa magwiridwe antchito a ziwalo zamkodzo, makamaka impso.

Kuphatikizidwa mu njira zochizira za Lipantil ndi mankhwala aliwonse ochokera ku gulu la statin ndikotheka pokhapokha ngati wodwalayo ali ndi vuto loopsa la mtima ndi vuto la mtima, chifukwa palibe mbiri yokhala ndi minyewa yokhala ndi minyewa. Chithandizo chimachitika pokhapokha ngati munthu akuwonetsetsa kuti ndi wovuta kuthandizirana.

Analogi ndi mtengo

Akatswiri a mtima amapereka mankhwala a Lipantil omwe amatsutsana ndi zosakaniza zake. Kubwezeretsanso kumachitika ndi mphamvu yochepa yogwiritsira ntchito kwa miyezi ingapo, kuchepa kosakwanira pamlingo wa triglycerides ndi lipoproteins yotsika mu systemic circ.

Mchitidwe wogwiritsa ntchito mankhwala omwe ali ndi kuthekera kwakukulu kosungunula mafuta a cholesterol ndikuwachotsa m'thupi. Mwa mawonekedwe ofanana ndi a Lipantil, Fenofibrate nthawi zambiri amalembedwa. Clofibrate ndi gemfibrozil ali ndi zochitika zofanana zochizira.

Mtengo wa Lipantil umasiyanasiyana pamadera osiyanasiyana mdzikolo. Ku Moscow, phukusi la mapiritsi No. 30 mu gawo la 200 mg lingagulidwe kwa ma ruble 780. Ku Nizhny Novgorod imakhala ndi ma ruble 800, ndipo ku Volgograd mtengo wake ndi ma ruble 820.

Kusankha kusankha kwa mankhwala abwino komanso apamwamba kwambiri kuti muchepetse kuchuluka kwa triglycerides m'magazi ndi kosavuta. Pamasamba azachipatala ndi azachipatala pamakhala ndemanga zambiri zabwino za Lipantil. Odwala matenda a mtima amati mankhwalawa amachotsa zizindikiro zonse za hyperlipidemia mkati mwa miyezi iwiri. Amagogomezera chitetezo cha mankhwala, chiwonetsero chochepa cha zoyipa zam'deralo komanso zadongosolo.

Maria Dmitrievna, wazaka 64, Ryazan: mulingo wa cholesterol wanga unayamba kukwera kuchokera wazaka 50. Poyamba, kunalibe zizindikiro, koma kenako thanzi lake linayamba kufooka. Mutu wanga unayamba kumva kulira, kupuma movutikira kunawoneka ngakhale ndikuyenda pang'ono. Cardiologist adalimbikitsa kutenga lipantil kapisozi kwa miyezi itatu. Thanzi lidayamba kuyenda bwino pafupifupi mwezi umodzi.

Nikolay, wazaka 49, Zheleznovodsk: Ndili ndi chibadwa chatsopano chotenga matenda a mtima. Chifukwa chake, dokotala wa mtima adapereka chithandizo atazindikira njira yayitali ya triglycerides. Poyamba ndinamwa mankhwala kuchokera ku gulu la statin, koma zotsatirapo zake zinali zoipa kuposa momwe ndimayembekezera. Dokotala adalimbikitsa kumwa lipantil pa mlingo wa 200 mg. Patatha miyezi itatu, kuchuluka kwa zamankhwala anali abwino kwambiri.

Mankhwala

Zogulitsa. Pambuyo pakukonzekera kwa Lipantil 200M Cmax kapisozi (pazinthu zambiri), fenofibroic acid amadza pambuyo maola 4-5. Pogwiritsa ntchito nthawi yayitali, ndende ya fenofibroic acid mu plasma imakhazikika, osasamala kanthu za zomwe wodwalayo ali nazo. Cmax m'magazi am'magazi komanso mphamvu yonse ya michere yamtengo wapatali fenofibrate imawonjezeka ndi chakudya.

Fenofibroic acid ndi okhazikika komanso woposa 99% womangidwa ku plasma albin.

Kutetemera ndi chimbudzi

Pambuyo pakukonzekera pakamwa, fenofibrate imatulutsidwa mofulumira ndi ma esterase kuti fenofibroic acid, omwe ndi metabolite yake yogwira. Fenofibrate sazindikira mu plasma. Fenofibrate si gawo limodzi la CYP3A4, silimagwira microsomal metabolism mu chiwindi.

Fenofibrate imapukusidwa makamaka mkodzo mu mawonekedwe a fenofibroic acid ndi glucuronide conjugate. Pakupita masiku 6, fenofibrate imachotsedweratu pafupifupi. Odwala okalamba, chiwonetsero chonse cha fenofibroic acid sichimasintha. Hafu ya moyo wa fenofibroic acid (T1 / 2) ndi pafupifupi maola 20. Pamene hemodialysis siziwonetsedwa. Kinetic Kafukufuku wasonyeza kuti fenofibrate siziunjikana pambuyo pa mlingo umodzi komanso kugwiritsa ntchito nthawi yayitali.

Wothandizidwa ndi hypolipidemic pagulu la zotumphukira za fibroic acid.Fenofibrate amatha kusintha zomwe zili mu lipid m'thupi la munthu kudzera mwa kugwiritsa ntchito kwa PPAR-α receptors (alpha receptors yokhazikitsidwa ndi peroxisome proliferator).

Fenofibrate imathandizira lipolysis ya plasma ndi kuchulukitsidwa kwa lipotrotein ya atherogenic yokhala ndi mawonekedwe apamwamba a triglycerides poyambitsa PPAR-α receptors, lipoprotein lipase ndikuchepetsa kapangidwe ka apoprotein C-III (apo C-III). Zotsatira zomwe zafotokozedwa pamwambapa zimayambitsa kuchepa kwa kachulukidwe kachulukidwe ka lipoprotein (LDL) komanso kachulukidwe kakang'ono kwambiri ka lipoprotein (VLDL), kamene kamakhala ndi apoprotein B (apo B), komanso kuwonjezeka kwa gawo la high density lipoprotein (HDL), kuphatikizapo apoprotein A-I ( apo A-I) ndi apoprotein A-II (apo A-II). Kuphatikiza apo, chifukwa cha kukonza kwa kaphatikizidwe ndi zovuta za catabolism za VLDL, fenofibrate imawonjezera kuwonekera kwa LDL ndikuchepetsa zomwe zili ndi tinthu tating'onoting'ono ta LDL (kuwonjezereka kwa LDL kumawonedwa mwa odwala omwe ali ndi atherogenic lipid phenotype ndipo amagwirizanitsidwa ndi chiopsezo cha matenda a mtima a coronary-IHD).

M'maphunziro azachipatala, zidadziwika kuti kugwiritsa ntchito fenofibrate kumachepetsa cholesterol yathunthu (Ch) ndi 20-25% ndi triglycerides ndi 40-55% ndi chiwopsezo cha HDL-C ndi 10-30%. Odwala omwe ali ndi hypercholesterolemia, momwe mulingo wa Chs-LDL amachepetsedwa ndi 20-35%, kugwiritsa ntchito fenofibrate kunapangitsa kutsika kwa ziwerengero: chonse Chs / Chs-HDL, Chs-LDL / Chs-HDL ndi pomwe B / apo A-I, omwe ali chizindikiro cha atherogenic chiopsezo.

Poganizira mphamvu ya fenofibrate pamlingo wa LDL-C ndi triglycerides, kugwiritsidwa ntchito kwa mankhwalawa kumagwira ntchito kwa odwala omwe ali ndi hypercholesterolemia, onse omwe amatsatana komanso osagwirizana ndi hypertriglyceridemia, mwachitsanzo, hyperlipoproteinemia, mwachitsanzo, ndi mtundu 2 shuga.

Pali umboni kuti fibrate ingachepetse kuchulukana kwa matenda a mtima, koma palibe umboni wotsimikiza kuti kufa kwa anthu m'matenda oyambira kapena owopsa.

Mukamalandira mankhwala a fenofibrate, zowonjezera zowonjezera za XC (tendon ndi tuberous xanthomas) zimatha kuchepa kwambiri mwinanso kutha kwathunthu. Odwala omwe ali ndi milingo yambiri ya fibrinogen omwe amathandizidwa ndi fenofibrate, kuchepa kwakukulu kwa chizindikirocho kunadziwika, komanso kwa odwala omwe ali ndi milingo yayitali ya lipoprotein. Mankhwalawa fenofibrate, kuchepa kwa kuchuluka kwa mapuloteni a C omwe amachititsa kuti maselo azitha kupanga.

Kwa odwala omwe ali ndi dyslipidemia ndi hyperuricemia, mwayi wowonjezera ndikuti fenofibrate imakhala ndi uricosuric, zomwe zimapangitsa kuchepa kwa kuchuluka kwa uric acid ndi pafupifupi 25%.

M'maphunziro azachipatala komanso zoyeserera za nyama, fenofibrate yawonetsedwa kuti ichepetse kuphatikiza kwa platelet chifukwa cha adenosine diphosphate, arachidonic acid, ndi epinephrine.

Zochita zamankhwala osokoneza bongo

Ma anticoagulants amlomo sakuvomerezeka nthawi yomweyo ndi Lipantil 200M. Fenofibrate imathandizira zotsatira za ma anticoagulants amkamwa ndipo imatha kuwonjezera ngozi yotuluka magazi. Kumayambiriro kwa mankhwala ndi fenofibrate, tikulimbikitsidwa kuchepetsa mlingo wa anticoagulants pafupifupi wachitatu, ndikutsatira posankha pang'onopang'ono kwa mlingo. Kusankhidwa kwa dose ndikulimbikitsidwa kuti kuchitika motsogozedwa ndi mulingo wa MHO (chiwembu cha mayiko wamba).

Cyclosporin. Milandu ingapo ikuluikulu yatsoka yomwe imagwiranso pakanthawi imodzi ndi fenofibrate ndi cyclosporine afotokozedwa. Chifukwa chake, ndikofunikira kuyang'anira momwe ntchito yaimpso imakhalira mwa odwala ndi kuletsa Lipantil 200M ngati pakuchitika masinthidwe akulu a ma labotale.

Co-A reductase inhibitors ndi ma fiber ena. Mukamamwa fenofibrate nthawi yomweyo monga HMG-CoA reductase inhibitors kapena ma fiber ena, chiopsezo cha zovuta zowopsa pamitsempha yamafupa chimakulitsidwa. M'pofunika kugwiritsa ntchito mankhwala a gululi omwe ali ndi Lipantil 200M mosamala, odwala amafunika kuwunika mosamala kuti awone ngati mankhwalawa akuvuta

Glitazones. Pali malipoti a kuchepa kwapang'onopang'ono kwa cholesterol ya HDL pomwe akutenga fenofibrate molumikizana ndi mankhwala ochokera ku gulu la glitazone. Chifukwa chake, tikulimbikitsidwa kuyang'anira kuchuluka kwa cholesterol ya HDL ndi kugwiritsa ntchito mankhwala osokoneza bongo kapena kuthetsedwa kwa m'modzi mwa iwo, wokhala ndi cholesterol yotsika kwambiri ya HDL.

Cytochrome P450 Enzymes. Kafukufuku wa in vitro wa microsomes a chiwindi chaumunthu awonetsa kuti fenofibrate ndi fenofibroic acid si zoletsa za isoenzymes CYP3A4, CYP2D6, CYP2E1 kapena CYP1A2. Pazowonjezera zochizira, zophatikizazi ndizofooka za CYP2C19 ndi CYP2A6 isoenzymes komanso zoletsa zochepa kapena zolimbitsa za CYP2C9.

Odwala omwe amamwa mankhwala ndi index yocheperako nthawi imodzi ndi fenofibrate, mu metabolism yomwe ma enzymes CYP2C19, CYP2A6 ndipo, makamaka, CYP2C9 akukhudzidwa, amafunikira kuwunika. Ngati ndi kotheka, kusintha kwa mankhwalawa kumalimbikitsidwa.