Momwe mungagwiritsire ntchito mankhwala Neyrolipon?

Parenteral, mkati 300 ndi 600 mg: diabetes komanso zakumwa zoledzeretsa.

Mkati mwa 12 ndi 25 mg: mafuta a chiwindi, matenda a chiwindi, matenda a chiwindi, hepatitis A, kuledzera (kuphatikizapo mchere wa zitsulo zolemera), poyizoni ndi toadstool, hyperlipidemia (kuphatikizapo kukula kwa koronary atherosulinosis - chithandizo ndi kupewa )

Zotsatira zoyipa

Kuchokera pamimba: mukamamwa mkamwa - nseru, kusanza, kupweteka m'mimba, kutsegula m'mimba.

Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa, urticaria, anaphylactic mantha.

Zina: mutu, kusokonezeka kwa glucose metabolism (hypoglycemia), ndi kayendetsedwe ka iv mofulumira - kuchepa kwakanthawi kochepa kapena kuvuta kupuma, kuchuluka kwazovuta zamkati, kupsinjika, diplopia, kutupa kwamatumbo pakhungu ndi mucous nembanemba komanso chizolowezi chakutulutsa magazi (chifukwa cha kuwonongeka kwa maphatikizidwe am'magazi )

Capsule Neurolipon (Neurolipon)

Malangizo ogwiritsira ntchito mankhwalawa

• Zizindikiro zogwiritsidwa ntchito
• Kutulutsa Fomu
• Pharmacodynamics wa mankhwala
• Pharmacokinetics wa mankhwala
• Gwiritsani ntchito pa nthawi yoyembekezera
• Contraindication
• Zotsatira zoyipa
• Mlingo ndi makonzedwe
• Bongo
• Kuchita ndi mankhwala ena
• Njira zopewera kugwiritsa ntchito
• Malo osungira
• Tsiku lotha ntchito

Gulu la Nosological (ICD-10)

Mlingo ndi makonzedwe

Mu / mu. Akuluakulu pa mlingo wa 600 mg / tsiku. Lowani pang'onopang'ono - osaposa 50 mg / min ya thioctic acid (1.7 ml ya njira yothetsera kulowetsedwa).

Mankhwalawa amayenera kuperekedwa ndi kulowetsedwa ndi 0,9% sodium chloride njira kamodzi patsiku (600 mg ya mankhwala osakanikirana ndi 50-250 ml ya 0.9% sodium chloride solution). Muzovuta kwambiri, mpaka 1200 mg zimatha kutumikiridwa. Malangizo a kulowetsedwa amayenera kutetezedwa ku kuwala powaphimba ndi zikopa zopepuka.

Njira ya mankhwalawa imachokera ku milungu iwiri mpaka inayi. Pambuyo pake, amasintha kukonzekera mankhwalawa ndi mitundu ya thioctic acid ya pakamwa pamankhwala a 300-600 mg / tsiku kwa miyezi 1-3. Kuphatikiza momwe mankhwalawa amathandizira, tikulimbikitsidwa kuti njira ya mankhwala ndi mankhwala a Neyrolipon iyenera kuchitidwa kawiri pachaka.

Kuchita bwino komanso chitetezo cha mankhwalawa kwa ana sichinakhazikitsidwe.

Kutulutsa Fomu

Tsatirani njira yothetsera kulowetsedwa, 30 mg / ml. M'magalasi akuda, okhala ndi mphete yopumira kapena 10 break.

5 kapena 10 amp. Pamodzi ndi thumba la filimu yakuda ya PE kapena popanda iyo phukusi la makatoni okhala ndi mabatani okhala ndi matayala.

5 amp. mu chithuza cha PVC film. 1 kapena 2 bl. yokhala ndi ma ampoules palimodzi ndi thumba la filimu yakuda ya PE kapena popanda iyo phukusi la makatoni.

Wopanga

PJSC Farmak. 04080, Ukraine, Kiev, st. Frunze, zaka 63.

Tel./fax: (8-10-38-044) 417-10-55, 417-60-49.

Bungweli likuvomera zomwe zimachitika kuchokera kwa ogula: ofesi yoyimira gulu la anthu Farmak JSC ku Russia: 121357, Moscow, ul. Chiyembekezo cha Kutuzovsky, 65.

Tele. ((495) 440-07-58, (495) 440-34-45.

Contraindication

Hypersensitivity pamagawo a mankhwala.

Mimba, nthawi yoyamwitsa (zinachitikira ndi mankhwalawa sizokwanira).

Ana ochepera zaka 18 (kuyenera ndi chitetezo chogwiritsa ntchito sanakhazikitsidwe).

Chowonjezera chotsutsana pakugwiritsa ntchito Neurolipon mu mawonekedwe a makapisozi ndi cholowa cha galactose chosagwirizana, kuperewera kwa lactase kapena galgose-galactose malabsorption.

Mankhwala

Gawo lomwe limagwira ntchito la Neyrolipon - thioctic acid - limapangidwa mwachindunji m'thupi ndipo limagwira ngati coenzyme mu oxidative decarboxylation ya α-ketonic acid. Udindo wofunikira umaseweredwa ndi thioctic acid mu metabolism yama cell. Mwanjira ya lipoamide, asidi amakhala ngati cofactor yofunikira ya ma enzyme angapo, omwe amathandizira pa decarboxylation ya α-keto acids pamajikelezo a Krebs.

Neyrolipon ali ndi antitoxic ndi antioxidant katundu, kuwonjezera apo, thioctic acid ikhoza kubwezeretsa ma antioxidants ena, mwachitsanzo, mu matenda a shuga, kuchepetsa insulin komanso kuchepetsa kuchepa kwa zotumphukira za neuropathy.

Thioctic acid imathandizira kuchepetsa shuga wa plasma ndikupanga glycogen m'chiwindi. Zimakhudza kagayidwe ka cholesterol, imagwira nawo ntchito yokhudzana ndi kagayidwe ka mafuta ndi chakudya, imayendetsa ntchito ya chiwindi chifukwa cha hepatoprotective, antioxidant komanso detoxification.

Pharmacokinetics

Makhalidwe a Pharmacokinetic malingana ndi momwe ntchito:

• m`kamwa makonzedwe: mayamwidwe limapezeka m'mimba thirakiti (m'mimba thirakiti) mwachangu komanso kwathunthu, pamene kudya Neurolipon ndi chakudya, mayamwidwe yafupika. Bioavailability amachokera 30 mpaka 60%, thunthu limapangidwa musanalowe mu kayendedwe ka magazi mukadutsa khoma la m'mimba thirakiti ndi chiwindi (mphamvu yoyamba). Nthawi yofika ndende yayikulu (T_max) ofanana ndi 4 μg / ml ndi pafupifupi mphindi 30. Kagayidwe mu chiwindi kumachitika ndi makutidwe ndi okosijeni am'mbali ndi conjugation. Thioctic acid imachotsedwa mkodzo kudzera mu impso: mu mawonekedwe a metabolites - 80-90%, osasinthika - ochepa. T_1/2 (theka-moyo) ndi mphindi 25,
• kholo makonzedwe: bioavailability ndi

30%, kagayidwe kumachitika m'chiwindi ndi makutidwe ndi okosijeni am'mbali ndi ma conjugation. T_1/2 - 20-50 mphindi, zivomerezo zonse ndi

694 ml / min, voliyumu yogawa ndi malita 12.7. Pambuyo jekeseni imodzi yokha ya thioctic acid m'mitsempha yake, kuphipha kwake kwa impso m'nthawi yoyamba 3-6 maola mpaka 93-97% mwa mawonekedwe osasintha kapena zinthu zina.

Malangizo ogwiritsira ntchito Neyrolipon: njira ndi mlingo

Neuroleipone yooneka ngati capsule imatengedwa pamlomo pamimba yopanda kanthu (theka la ola musanadye), osafuna kutafuna ndi kumwa ndi madzi pang'ono kapena madzi osagwirizana nawo.

Mlingo woyenera: 300-600 mg kamodzi patsiku. Zochizira kwambiri matenda ashuga polyneuropathy poyambira, makolo ake a thioctic acid ndi abwino.

Dokotala amawona kutalika kwa njira ya mankhwalawa payekhapayekha.

Tsatirani njira yothetsera kulowetsedwa

Njira yothetsera kuchokera ku Neyrolipon yokhazikika imayendetsedwa ndi kulowetsedwa kwapang'onopang'ono (≤ 50 mg thioctic acid pamphindi).

Mlingo woyenera: 600 mg kamodzi patsiku, woopsa, mpaka 1200 mg ndikuloledwa.

Kukonzekera kulowetsedwa, 0.9% NaCl yankho imagwiritsidwa ntchito mpaka 50-250 ml pa 600 mg ya thioctic acid.

Kutalika kwa nthawi ya maphunzirowa ndi masabata 2- 4, kenako amasintha mankhwalawa pogwiritsa ntchito mankhwala osakanikirana atatu (300-600 mg patsiku) kwa miyezi 1-3.

Kuti muphatikize zotsatira za Neyrolipona tikulimbikitsidwa kuti tichite maphunziro obwereza kawiri kawiri pachaka.

Bongo

Zizindikiro za bongo wa thioctic acid atatengedwa pakamwa, nseru, kusanza, kukhudzika kwakukulu, kusokonezeka kwakukulu mu acid-base balance ndi lactic acidosis, hypoglycemic chikomokere, magazi okokomeza a m'mitsempha.

Pofuna kuthana ndi vutoli, muyenera kusiya kumwa mankhwalawo, kusamba m'mimba, kenako ndikuthira makala ndi kukonza mankhwalawo.

Zizindikiro zakuchuluka kwa thioctic acid wokhala ndi makulidwe a makolo sizikudziwika.

Ngati mukukayikira mankhwala osokoneza bongo kapena kupezeka kwa zovuta zoyipa, muyenera kusokoneza kulowetsedwa, ndiye, osachotsa singano ya jekeseni, pang'onopang'ono mupeze yankho la 0.9% isotonic NaCl kudzera munjira. Mankhwala alibe mankhwala enaake;

Malangizo apadera

Mayankho a kulowetsedwa okhala ndi thioctic acid ayenera kutetezedwa ku kuwala pophimba zida zokhala ndi zikopa zopepuka.

Mankhwalawa odwala omwe ali ndi matenda ashuga, kuwunika pafupipafupi kuchuluka kwa shuga m'magazi kumafunika, nthawi zina, ngati kuli kotheka, kusintha kwa mankhwalawa kwa othandizira a hypoglycemic pofuna kupewa kukula kwa hypoglycemia.

Pa chithandizo ndi Neurolipone, munthu ayenera kupewa zakumwa zomwe zimakhala ndi mowa, chifukwa ethanol imaletsa ntchito zake zochizira.

Kuyanjana kwa mankhwala osokoneza bongo

• glucocorticosteroids: asidi wa thioctic amawonjezera mphamvu yawo yotsutsana ndi kutupa,
• chisplatin: kuchepa kwake pochiritsa kumadziwika,
• mankhwala okhala ndi zitsulo (chitsulo, magnesium, calcium kukonzekera): thioctic acid imamanga zitsulo, motero, kuyendetsa kwawo munthawi yomweyo kuyenera kupewedwa, ndikofunikira kuti pakhale nthawi yayitali pakati pa Mlingo osachepera maola 2,
• insulin kapena mkamwa hypoglycemic wothandizila: thioctic acid akhoza kuyambitsa zotsatira zawo,
• Mowa ndi metabolites: ziletsa zochita za thioctic acid.

Njira yothetsera ya Neyrolipon imalephera kusakanikirana ndi mashuga, motero siyigwirizana ndi mayankho a Ringer, glucose, ndi fructose. Ndizosagwirizana ndi mayankho a mankhwala omwe amakhudzana ndi magulu a SH-magulu kapena kuwononga milatho ndi kukonzekera komwe kumakhala ndi ethanol.

Ndemanga za Neyrolipone

Ndemanga za neuroleepone ndizotsutsana. Kwa odwala ena, mankhwalawa sioyenera, amatchulidwa ngati chithandizo chosagwira bwino chomwe chimachepetsa pang'onopang'ono zizindikiro za matendawa ndikupangitsa zovuta zoyipa.

Mu ndemanga zina zingapo, neurolypone imadziwika kuti ndi mankhwala osankhidwa chifukwa chosagwirizana ndi zovuta komanso kuyendetsa bwino kwambiri.

Mtengo wa Neyrolipon m'masitolo ogulitsa mankhwala

Mtengo woyerekeza wa NeroLipone:

• khazikitsani mtima pansi pakukonzekera njira yothetsera kulowetsedwa (ma ampoules asanu pakatoni): ma ampoules a 10 ml - ma ruble 170, m'mapulogalamu 20 20 - ma ruble a 360,
• makapisozi (ma PC 10. m'matumba, matuza atatu muthumba la makatoni) - ma ruble 250.

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo aboma. Kudzipatsa nokha mankhwala kuopsa!

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Njira yothetsera kulowetsedwa imaperekedwa kudzera kwa akulu kwa mlingo wa 600 mg patsiku. Imayendetsedwa pang'onopang'ono - osaposa 50 mg ya thioctic acid (1.7 ml ya njira yothetsera kulowetsedwa) miniti.

Mankhwalawa amayenera kuperekedwa ndi kulowetsedwa ndi 0,9% sodium chloride njira imodzi patsiku (600 mg ya mankhwala osakanikirana ndi 50-250 ml ya 0.9% sodium chloride solution). Muzovuta kwambiri, mpaka 1200 mg zimatha kutumikiridwa. Malangizo a kulowetsedwa amayenera kutetezedwa ku kuwala powaphimba ndi zikopa zopepuka.

Njira ya mankhwalawa imatha 2 kapena 4 milungu. Pambuyo pake, amasintha kukonzanso mankhwala a Neyrolipon pamlomo wapakhungu (makapisozi) pamankhwala a 300-600 mg patsiku kwa miyezi 1-3. Makapisozi amatengedwa pakamwa popanda kutafuna, kutsukidwa ndimadzi pang'ono, mphindi 30 asanadye (pamimba yopanda kanthu). Kuphatikiza momwe mankhwalawa amathandizira, njira yochiritsira imalimbikitsidwa 2 pachaka.

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Kuchita bwino komanso chitetezo cha mankhwalawa kwa ana sichinakhazikitsidwe.

Zotsatira za pharmacological

Thioctic acid, yomwe ndi gawo la Neuroleipon, imapangidwa mthupi ndipo imagwira ntchito ngati coenzyme mu oxidative decarboxylation ya alpha-keto acids, ndipo imagwira gawo lofunikira mu kagayidwe kazinthu zama cell. Mu mawonekedwe amide (lipoamide) ndi cofactor yofunikira ya ma enzyme ambiri omwe amachititsa ma decarboxylation a Krebs alpha-keto acids. Thioctic acid imakhala ndi zotsatira za antitoxic ndi antioxidant, imathanso kubwezeretsa ma antioxidants ena, monga matenda a shuga. Odwala omwe ali ndi matenda ashuga, thioctic acid amachepetsa kukana kwa insulin ndipo amalepheretsa chitukuko cha zotumphukira za m'mitsempha.

Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi am'magazi komanso kuchuluka kwa glycogen m'chiwindi. Thioctic acid imakhudzanso kagayidwe ka cholesterol, imatenga gawo mu kayendedwe ka lipid ndi carbohydrate metabolism, imayendetsa ntchito ya chiwindi (chifukwa cha hepatoprotective, antioxidant, detoxification zotsatira).

Kuchita

Imapititsa patsogolo anti-yotupa ya glucocorticosteroid mankhwala.

Ndi makonzedwe apakati a thioctic acid ndi cisplatin, kuchepa kwa mphamvu ya chisplatin kumadziwika.

Thioctic acid imamanga zitsulo, motero, sayenera kutumizidwa nthawi yomweyo ndi mankhwala okhala ndi zitsulo (mwachitsanzo, chitsulo, magnesium, calcium) - nthawi yayitali pakati pa Mlingo uyenera kukhala osachepera maola 2.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala a thioctic acid ndi insulin kapena pakamwa hypoglycemic, zotsatira zawo zitha kukhala zabwino.

Mowa ndi metabolites ake umafooketsa mphamvu ya neuroleipone.