Tsifran OD > Chithandizo ndi kupewa

Tsifran OD imapezeka m'mapiritsi okhala ndi zochita zazitali, zokhala ndi utoto: kuyambira pafupi mpaka loyera, chowulungika, pamwambo wa kanema pamakhala cholembera cha inki yakuda ya chakudya "Cifran OD 500 mg" kapena "Cifran OD 1000 mg" (ma 5 ma PC. , pa kakhadakhadi kokhala ndi matuza 1 kapena 2).

Piritsi limodzi lili:

yogwira pophika: ciprofloxacin - 500 mg kapena 1000 mg,
othandizira: masodium bicarbonate, sodium alginate (Kelton LVCR), crospovidone (Kollidon CLM), hydroxypropyl methylcellulose, magnesium stearate, aerosil 200, talc,
kapangidwe ka zipolopolo: Opadry 31B58910 loyera (lactose monohydrate, hypromellose, macrogol 400, titanium dioxide), talc, hydroxypropyl methylcellulose, madzi oyeretsedwa.

Mankhwala

Tsifran OD ndi mankhwala oletsa kuponderezana. Kapangidwe ka kachitidwe kake kamachitika chifukwa cha bactericidal zochita za ciprofloxacin (fluoroquinolone), yomwe imasokoneza zochita za topoisomerase II, puloteni yofunikira ya bakiteriya yofunikira kupatsanso mtundu wina wa bakiteriya (deoxyribonucleic acid). Kupezeka kwa topoisomerase mu biochemical process kumayambitsa kuphwanya kapangidwe ka mapuloteni abwinobwino m'mabakiteriya.

Ciprofloxacin imagwira ntchito molimbana ndi mitundu ingapo ya mabakiteriya otsatirawa:

Gram-positive aerobic: Listeria monocytogenes, Bacillus anthracis, Enterococcus faecalis (kudziwa za abale pazovuta zambiri), Streptococcus pyogene, Staphylococcus epermidis, Staphylococcus aureus (methicillin-chidwi komanso kupangitsa kuti penicillococcus, pintana -ukutukutu;
Gram-negative aerobic: Citrobacter diversus, Campylobacter jejuni, Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Moraxella catarrhalis, Haemophilus parainfluenzae, Haemophilus fuluwenza, Klebsiella pneumoniae, Morganella gerogoromererg , Shigella boydii, Shigella flexneri, Shigella dysenteriae, Shigella sonnei, Salmonella typhi.

In vitro, ciprofloxacin osachepera inhibitory concentration (MIC) ya 0,001 mg / ml ikugwira ntchito motsutsana ndi zoposa 90% ya zovuta zotsatirazi (zovuta zamtunduwu sizinafotokozedwe):

gram-zabwino: Staphylococcus haemophilus, Staphylococcus hominis,
Gram-negative aerobic: Edwardsiella tarda, Aeromonas hydrophila, Acinetobacter lwoffii, Brucella melitensis, Salmonella enterit>

Kukaniza kwa ciprofloxacin kumawonetsedwa ndi: Burkholderia cepacia (madera ambiri), Stenotrophomonas maltophilia (ena mabungwe), Bacteroides fragilis, Clostridium Hardile ndi mabakiteriya ena ambiri a anaerobic.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, mayamwidwe a ciprofloxacin kuchokera m'mimba thirakiti limachitika mofulumira. Kutulutsidwa kwanthawi yayitali kwa ciprofloxacin kumathandizira kuti azisungika nthawi yayitali m'magazi a Cifran OD 1 patsiku.

Kuzindikira ndende (C_max) mankhwala omwe amagwira m'magazi am'magazi amafikira maola 6 ndipo atha kukhala pafupifupi 0.0013 mg / ml pambuyo pa gawo limodzi la mapiritsi a cyfran OD 500 mg ndi 0,0024 mg / ml - Tsifran OD 1000 mg. Chiwerengero chonse cha plasma (AUC) cha ciprofloxacin pamenepa chimafanana pafupifupi 0.0083 ndi 0.0189 mg / ml / h.

Ndi mapuloteni am'madzi am'magazi amamanga 20-40%.

Ciprofloxacin imalowa mosavuta m'madzi amthupi ndi zimakhala. Imapezeka pamasamba, kubisala kwa mucous nembanemba ndi bronchi, zamitsempha, zotumphukira zamkati, umuna, ndi kubisala kwa ndulu ya prostate. Amagawidwa m'mapapu, khungu, minofu, adipose, cartilage ndi minofu yamafupa, gland ya prostate.

Mu chiwindi, ciprofloxacin imapangidwa pang'ono.

T_1/2 (theka-moyo) - maola 3.5-4.5.

Pafupifupi 50% ya mankhwala omwe amumwa pakamwa amachotsedwa mu impso osasinthika, pafupifupi 15% mu mawonekedwe a metabolites yogwira. Pafupifupi 35% ya mlingo womwe umalandira.

Kulephera kwakukulu kwa aimpso komanso kwa achikulire, T_1/2 Itha kutalikitsidwa, motero, dongosolo la mankhwalawa liyenera kusinthidwa poganizira kulengedwa kwa creatinine (CC) kwa wodwalayo.

Ndi njira yokhazikika ya cirrhosis, ma pharmacokinetics a ciprofloxacin sasintha kwenikweni. Chenjezo liyenera kuchitidwa pakulakwitsa pachimake kwa chiwindi chifukwa chosowa deta pa kinetics ya chinthu yogwira.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Tsifran OD ikuwonetsedwa zochizira matenda opatsirana komanso otupa oyambitsidwa ndi tizilombo tating'onoting'ono:

chibayo, kuchulukitsa kwa matenda osakhazikika, matenda opatsirana a cystic fibrosis ndi matenda ena otupa a m'munsi kupuma kwamatenda a etiology,
sinusitis pachimake
cystitis, pyelonephritis (kuphatikizapo mitundu yovuta),
chinzonono
bacterial prostatitis,
cholecystitis, cholangitis, kupondaponda kwa ndulu, peritonitis, zotupa zamkati ndi zotupa zina zamkati mwa m'mimba - kuphatikiza ndi metronidazole,
matenda amkati
pachimake ndi mawonekedwe a osteomyelitis ndi matenda ena opatsirana a mafupa ndi mafupa,
anthrax,
kutsegula m'mimba kuchokera ku matenda opatsirana (kuphatikiza "oyenda m'mimba"),
matenda a typhoid.

Contraindication

Kulephera kwa impso (ndi CC zosakwana 29 ml / min, kuphatikizapo odwala hemodialysis),
pseudomembranous colitis,
mankhwala amodzi ndi tizanidine,
wazaka 18
nthawi yapakati
yoyamwitsa
Hypersensitivity a mankhwala a gulu la fluoroquinolone,
tsankho limodzi ndi zigawo zikuluzikulu za mankhwala.

Mosamala, ndikofunikira kupereka ntchito ya Tsifran OD mu chiwindi kwambiri, kulephera kwaimpso ndi CC ya 35-50 ml / min, ngozi yamitsempha, matenda oopsa amitsempha yamagazi, matenda amisala, khunyu, kuwonongeka kwa tendon panthawi yam'mbuyomu chithandizo ndi fluoroquinolones, mu ukalamba.

Malangizo ogwiritsira ntchito Tsifran OD: njira ndi mlingo

Mapiritsi a Cifran OD amatengedwa pakamwa, mutatha kudya, kumeza lonse (popanda kuswa nembanemba) ndikumwa madzi ambiri.

Wodwalayo amatenga mlingo 1 nthawi patsiku.

Mlingo wovomerezeka wa Tsifran OD:

yotupa ndi yotupa pathologies a m'munsi mwa kupuma dongosolo: zovuta komanso modekha - 1 g kwa masiku 7 mpaka 14, mawonekedwe osavuta - 1.5 g kwa masiku 7-14,
sinusitis pachimake: kufatsa pang'ono - 1 g kwa masiku 10,
kwamikodzo thirakiti matenda: mawonekedwe osavuta - 0,5 ga kwa masiku atatu, kuuma koopsa - 0,5 g kwa masiku 7 mpaka 14, mawonekedwe osavuta - 1 g kwa 7 -Masiku 14
chinzonono: mawonekedwe osavuta - 0,5 ga tsiku 1, zovuta - 0,5 g kwa masiku atatu,
bakiteriya matenda a prostatitis: kuuma koopsa komanso koyenera - 1 g iliyonse, kutalika kwa njira ya chithandizo ndi masiku 28,
matenda okhudzana ndi intraperitoneal (kuphatikiza ndi metronidazole): mitundu yovuta - 1 g kwa masiku 7-14,
matenda opatsirana a pakhungu: kuuma kwambiri - 1 g kwa masiku 7-14, njira zowopsa komanso zovuta - 1.5 g, njira ya mankhwalawa - masiku 7-14,
matenda opatsirana a mafupa ndi mafupa: kuuma koopsa - 1 g kwa masiku 28-42, mawonekedwe osavuta - 1.5 g kwa masiku 28-42 kapena kuposerapo,
matenda am'mimba opatsirana amatenda opatsirana: ofatsa, ochepa kapena owopsa - 1 g kwa masiku 5-7,
matenda a typhoid: kuuma pang'ono - - 1 ga kwa masiku 10,
anthrax (kupewa ndi kuchiza): 1 g iliyonse, nthawi yayitali - masiku 60.

Kuvomerezedwa kwa mankhwalawa kuyenera kupitilizidwa kwa masiku osachepera masiku awiri atatha kutha kwa zizindikiro za matenda.

Pakulephera kwa impso, kuwongolera kwa dongosolo la Tsifran OD kumachitika poganizira QC ya wodwalayo motere:

QC pamwamba pa 50 ml / mphindi: mlingo wamba,
KK 30-50 ml / mphindi: 0.5-1 g patsiku,
QC 5 - 29 ml / mphindi, odwala hemodialysis kapena peritoneal dialysis: ntchito osavomerezeka.

Kwa abambo, QC ikhoza kutsimikizika mwa kuchulukitsa kulemera kwa makilogalamu (makilogalamu) ndi kusiyana komwe kumapezeka pambuyo pochotsa zaka zake zakubadwa za 140 zaka. Zotsatira zake zimagawidwa ndi mankhwala - chiwerengero chomwe chimapezeka pochulukitsa makumi asanu ndi awiri mothandizidwa ndi creatinine m'madzi a m'magazi (mg / dl).

Kwa akazi, QC imafanana ndi cholembera chomwe chimawerengeredwa malinga ndi chiwembu cha amuna, komanso kuwonjezera kuchuluka kwa 0.85.

Odwala okalamba, kuikidwa kwa fluoroquinolones kuyenera kuchitika chifukwa cha kuchepa kwa zaka zokhudzana ndi impso.

Zotsatira zoyipa

Kuchokera kwamankhwala amanjenje: Photophobia, kusowa tulo, kukwiya, kupweteka mutu, chizungulire, kutopa kwambiri, kupweteka kwa mutu, kugona, nkhawa, kunjenjemera, chisokonezo, kufooka kwa ziwalo (kukhumudwa kwam'mimba), kukhumudwa, kuchuluka kwazovuta zamkati, kuyerekezera zinthu, kukomoka, kuwonetsa machitidwe amtopola (kuphatikizapo kudzivulaza), matenda am'mimba a mitsempha, migraine,
kuchokera ku ziwalo zam'malingaliro: kusokonezeka kwa kununkhira ndi kukoma, diplopia, kusamva, tinnitus,
Kuchokera kumimba: kupondaponda, kupweteka kwam'mimba, mseru, kusanza, matenda am'mimba, chiwindi, hepatitis, cholestatic jaundice (nthawi zambiri motsutsana ndi maziko a matenda am'mbuyomu), hepatonecrosis,
Kuchokera pamtima dongosolo: kutsitsa magazi (BP), tachycardia, kutupa kwa nkhope, kusokonekera kwa mtima,
Kuchokera hematopoietic dongosolo: leukopenia, granulocytopenia, eosinophilia, kuchepa magazi, thrombocytopenia, hemolytic anemia, leukocytosis, thrombocytosis,
Kuchokera kwamikodzo dongosolo: kwamikodzo posungira, hematuria, dysuria, polyuria, crystalluria (nthawi zambiri motsutsana ndi maziko amchere wamkodzo, kutsika kwamkodzo), pachimake pakati, nephritis, magaziinuria, glomerulonephritis, urethral magazi, kuchepa kwa impso,
Kuchokera ku chitetezo chamthupi: kuyabwa pakhungu, kutentha kwa mankhwala, urticaria, petechiae, matuza (kuphatikiza magazi), maonekedwe a timinofu ting'onoting'ono tomwe timapanga khungu, kufupika kwa mpweya, kutupa kwa nkhope ndi / kapena larynx, erythema nodosum, vasculitis, erythema multiforme, matenda oopsa a epermermal necrolysis (matenda a Lyell), erythema (Stevens-Johnson syndrome),
Kuchokera kwamankhwala oyendetsa minofu ndi mafupa: nyamakazi, tenosynovitis, arthralgia, myalgia, tendon ruptures,
magawo a labotale: hypercreatininemia, hypoprothrombinemia, hyperglycemia, kuchuluka kwa hepatic transaminases, hyperbilirubinemia, kuchuluka kwa lactate dehydrogenase ndi alkaline phosphatase,
ena: kufooka kwakukulu, thukuta kwambiri, pseudomembranous colitis, candidiasis, photosensitivity.

Bongo

Zizindikiro: Zotsatira zoyipa za impso.

Chithandizo: palibe mankhwala enaake. Pankhaniyi, ndikofunikira kukakamiza kusanza kapena kutsuka m'mimba. Chotsatira ndi kukhazikitsidwa kwa chithandizo chothandizira, kuphatikiza infusions ndi njira zina zokwanira hydrate, kukonza makhwala. Kugwiritsa ntchito hemo- ndi peritoneal dialysis sikuthandiza; mpaka 10% ya mlingo wovomerezeka wa ciprofloxacin ukhoza kuchotsedwa.

Malangizo apadera

Chifukwa cha chiwopsezo cha kuphatikizika kwa photosensitivity komwe kumakhudzana ndi kugwiritsa ntchito fluoroquinolones, kuwonetsa kwambiri ma radiation ya ultraviolet, kuphatikiza dzuwa mwachindunji, kuyenera kupewedwa panthawi yamankhwala. Ngati zithunzi zam'maso zikuchitika, mapiritsi ayenera kusiyidwa.

Pozindikira chomwe chimayambitsa matenda otseguka m'mimba omwe amatenga nthawi yayitali kapena atangomaliza chithandizo cha Cifran OD, kukula kwa pseudomembranous colitis kuyenera kuganiziridwanso. Ngati pseudomembranous colitis imatsimikiziridwa, kusiya kwa mankhwala mwachangu ndikusankhidwa kwa chithandizo choyenera ndikofunikira.

Popewa kukula kwa mankhwala a crystalluria panthawi yomwe mukumwa mapiritsi, ndikofunikira kumwa madzi okwanira, kukhalabe ndi mkodzo komanso kupewa kuchuluka kwa tsiku ndi tsiku kwa mankhwalawa.

Popeza ndi mbiri yachilendo zotupa zamafupa, zotupa zam'mimba, khunyu, kapena kugwidwa, ciprofloxacin imayambitsa chitukuko cha zovuta kuchokera ku dongosolo lamanjenje, odwala omwe ali ndi matenda awa amatha kuyatsidwa Tsifran OD kokha chifukwa cha thanzi.

Odwala ayenera kudziwitsidwa za kufunika kosiya mankhwala pokhapokha ngati pali zowawa m'misempha ndi zizindikiro zoyambirira za tenosynovitis.

Mlingo

Mapiritsi okhala ndi filimu yokutidwa ndi 500 mg ndi 1000 mg

Piritsi limodzi lili

ntchito yogwira - ciprofloxacin 500 mg ndi 1000 mg

tsimikizira: sodium alginate, hypromellose, sodium bicarbonate, crospovidone, magnesium stearate,

kuchuluka: magnesium yakuthwa, talcon dioxide colloidal anhydrous,

chipolopolokoma: Opadry 31V58910 loyera (hypromellose, lactose monohydrate, titanium dioxide (E171), macrogol 400, hypromellose, talc yoyeretsedwa,

inkiOpacodeS-1-17823 (Chakuda): glossy shellac, isopropyl mowa, chonde oxide / chonde oxide wakuda (E 172), butyl mowa, propylene glycol, 28% yankho la ammonia.

Mapiritsi okhala ndi mawonekedwe a Oval atakulungidwa ndi filimu yotulutsa kuyambira yoyera mpaka pafupifupi yoyera, ndipo cholembedwa "Cifran OD 500 MG" mu inki mbali imodzi. Kutalika 17.1  0,1 mm, m'lifupi 8.1  0,1 mm, makulidwe 5.6  0,3 mm (kwa mulingo wa 500 mg).

Mapiritsi okhala ndi mawonekedwe a Oval atakulungidwa ndi filimu yokhala ndi zoyera kuyambira zoyera mpaka pafupi zoyera, zolembedwa "Cifran OD 1000 MG" mu inki mbali imodzi. Kutalika 21.2  0,1 mm, m'lifupi 10,6 mm 0,1 mm, makulidwe 7.6  0,3 mm (kwa mulingo wa 1000 mg).

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo Tsifran OD:

metronidazole, beta-lactams, clindamycin, aminoglycosides ndi antimicrobials ena: chifukwa synergism. Kwa chithandizo chopambana chamatenda oyambitsidwa ndi masheya a Pseudomonas, kuphatikiza kwa ceftazidime ndi azlocillin, matenda a streptococcal omwe ali ndi mankhwala a beta-lactam (meslocillin, azlocillin), matenda a staphylococcal omwe ali ndi vancomycin, isoxazolpenicillin matenda, anaerobic aminerocytamines, anaerobic aminerocytamines
theophylline: imakulitsa kuchuluka kwake m'magazi am'magazi,
tizanidine: imawonjezera chiopsezo cha kutsika kwakukulu kwa kuthamanga kwa magazi, mawonekedwe a kugona,
immunosuppress and antitumor mankhwala: kuchepetsa kuyamwa kwa cyfran OD mukamwa,
didanosine: amathandiza kuchepetsa mayamwidwe a ciprofloxacin,
Maantacid okhala ndi ma aluminium kapena magnesium hydroxide pakapangidwe: amathandizira kuchepa kwa mayamwidwe a ciprofloxacin, chifukwa chake kuphatikizaku kumatsutsana.
mankhwala omwe amatchinga katulutsidwe ka tubular, kuphatikiza phenenecid: kuchepetsa aimpso zotupa za ciprofloxacin,
analgesics: zimayambitsa zotsatira zoyipa za ciprofloxacin kuchokera ku ubongo wamkati,
phenytoin: itha kuchepa kapena kuwonjezera kuchuluka kwako kwa plasma,
sucralfate: kumachepetsa kuyamwa kwa Cyfran OD,
otsutsa a H₂- histamine receptors: palibe zotsatira zamankhwala zazing'ono kwambiri pa bioavailability ya ciprofloxacin,
anticoagulants mkamwa, kuphatikizapo warfarin ndi zotumphukira zake: zimathandizira, chifukwa chake, akaphatikizidwa ndi mankhwala, kafukufuku wokhazikika wa njira yoyipa ya magazi amafunikira,
glyburide: imatha kuyambitsa hypoglycemia,
othandizira a hypoglycemic, caffeine ndi ma xanthine ena: amalimbikitsa kuchuluka kwawo ndikukukulitsa T_1/2,
metoclopramide: imathandizira mayamwa,
othandizira uricosuric: pafupifupi 50% imachepetsa kuchotsedwa kwa kuprofloxacin, ndikuwonjezera kuchuluka kwa plasma ndende,
cyclosporine: imawonjezera mphamvu yake ya nephrotoxic. Popeza pali kuchuluka kwa serum creatinine, mulingo wake uyenera kuyendetsedwa kawiri pa sabata.

Mafanizo a Cifran OD ndi awa: Cifran, Ciprofloxacin, Vero-Ciprofloxacin, Ifippro, Quintor, Basigen, Betaciprol, Nircip, Procipro, Ciprinol, Ciprobay, Ciprolaker, Cipromed, Ciprofloxabol, Ciploxinal, Ciprox.

Mankhwala

Ciprofloxacin mapiritsi otulutsidwa amasulidwe amapangidwa kuti amasule mankhwalawo pamlingo wotsikirapo poyerekeza ndi mapiritsi akumasulidwa.

Mbiri ya pharmacokinetic ya ciprofloxacin mapiritsi okhazikika-a 1000 mg kamodzi tsiku lililonse imafananizidwa ndi mbiri ya mapiritsi a 500 mg aprofloxacin omasulidwa mwachangu kawiri patsiku, malinga ndi kufananizira kwa Auc kwa maola 24.

Pambuyo pakukonzekera pakamwa, ciprofloxacin imatengedwa mwachangu kwambiri m'matumbo aang'ono. Kuchuluka kwakukulu kwa ciprofloxacin mu seramu kumatheka pambuyo pa maola 1-2. Bioavailability pafupifupi 70-80%. Makhalidwe azachuma kwambiri mu plasma (Cmax) ndi dera lomwe kumapeto kwa "ndende - nthawi" (AUC) akuwonjezeka molingana ndi mlingo.

Kulumikizidwa kwa ciprofloxacin ndi mapuloteni a plasma ndi 20-30%, chinthu chogwira ntchito chimapezeka m'madzi a m'magazi makamaka osakhala ionized. Ciprofloxacin imagawidwa mwaulere mu zimakhala ndi zithupi za mthupi. Kuchuluka kwa magawo m'thupi ndi 2-3 l / kg. Kuchuluka kwa ciprofloxacin mu minofu ndikwapamwamba kwambiri kuposa kuchuluka kwa seramu yamagazi.

Biotransformed mu chiwindi. Amayi anayi a profrofloxacin metabolites ang'ono ang'onoang'ono amatha kupezeka m'magazi: diethylcycrofloxacin (Ml), sulfociprofloxacin (M2), oxociprofloxacin (MZ), formylcycrofloxacin (M4), atatu omwe (M1-MZ) amawonetsa zochita za antibacterial zomwe zingagonjetse zinthu zina zotere. ma acid. Ntchito ya antibacterial ya in vitro metabolite M4, yomwe ilipo yaying'ono, imagwirizana kwambiri ndi zochitika za norfloxacin.

Ciprofloxacin imachotseredwa makamaka ndi impso kudzera mu kusefera kwake kwakanthawi komanso katulutsidwe ka tubular, ndalama zochepa kudzera m'mimba. Kuchiritsa kwamankhwala kumachitika pakatha maola 24 mutatha kumwa mankhwalawo. Kuyambira 1 mpaka 2% ya mlingo womwe unatengedwa umapukusidwa mu mawonekedwe a metabolites ndi bile, pafupifupi 20-35% ya mankhwalawa amachotsedwa mu ndowa mkati mwa masiku 5 atatha kuperekedwa. Seramu theka moyo odwala odwala yachilendo aimpso pafupifupi 7 maola.

Pharmacokinetic imawunika mapiritsi otulutsira pakamwa posachedwa (limodzi mlingo) ndi mafrofloxacin mafupa amkati mwachindunji (kamodzi komanso zingapo) akuwonetsa kuti kuchuluka kwa plasma kwa ciprofloxacin ndizokwera kwambiri kwa anthu okalamba (opitilira 65) poyerekeza ndi achikulire achinyamata. Cmax imakwera kuchokera ku 16% mpaka 40%, ndipo AUC wamba imakwera pafupifupi 30%, yomwe mwina imakhala chifukwa chakuchepa kwa impso kwa okalamba. Hafu ya moyo imakhala yotalikirapo pang'ono mwa okalamba (

20%). Kusiyana kumeneku sikofunikira pachipatala.

Odwala omwe ali ndi vuto laimpso, theka la moyo wa ciprofloxacin atha kukulitsidwa. Kusintha kwa Mlingo sikofunikira kwa odwala omwe ali ndi zovuta kwamikodzo thirakiti kuti alandire 500 mg ya fomu yayitali ya ciprofloxacin. Kwa matenda amkodzo amtundu wovuta komanso pachimake kupweteka kosavuta kwa pyelonephritis, komwe mlingo wa 1000 mg umagwiritsidwa ntchito, mlingo wa ciprofloxacin womwe umakhalapo nthawi yayitali uyenera kuchepetsedwa mpaka 500 mg kamodzi patsiku (kulengedwa kwa creatinine pansi pa 30 ml / min).

Pakufufuza kwa odwala omwe ali ndi matenda osatha a chiwindi, palibe kusintha kwakukulu mu pharmacokinetics of ciprofloxacin. Nthawi yomweyo, kinetics ya ciprofloxacin kwa odwala omwe ali ndi vuto la chiwindi cholimba amadziwika.

Ciprofloxacin ndi mankhwala opanga ma antibacterial opangidwa kuchokera ku gulu la fluoroquinolones.

Ciprofloxacin ali ndi ntchito za vitro motsutsana ndi mitundu ingapo yama gram-negative ndi gram-virus. Machitidwe a bactericidal a ciprofloxacin amachitika ndi kuletsa mtundu wachiwiri wa bakiteriya topoisomerases (topoisomerase II (DNA gyrase) ndi topoisomerase IV), zomwe ndizofunikira pakubwereza, kusindikiza, kukonza ndikonzanso kabakiteriya.

Mu vitro kukana ciprofloxacin nthawi zambiri amayamba chifukwa cha masinthidwe a bakiteriya topoisomerases ndi DNA gyrase ndipo imayamba pang'onopang'ono kudzera pakusintha kwamitundu yambiri.

Kusintha kwamtundu umodzi kumatha kuyambitsa kuchepa kwa chidwi kuposa kukhazikika kwa chipatala, komabe, kusinthika kambiri kumayambitsa kukula kwa kukana kwamankhwala kwa ciprofloxacin komanso kutsutsana ndi mankhwala a quinolone. Kukana kwa ciprofloxacin, monga maantibayotiki ena, kumatha kupangidwa chifukwa chakuchepa kwa kuchuluka kwa khoma la bakiteriya (monga momwe zimakhalira ndi Pseudomonas aeruginosa) ndi / kapena kuyambitsa kutulutsa kwa cell cell (efflux). Kukhazikika kwa kukana chifukwa cha kukhazikitsa Qnr gene komwe kumaikidwa pa plasmids akuti. Njira zotsutsa zomwe zimapangitsa kuti ma penicillin apangidwe, ma cephalosporins, amino glycosides, macrolides, ndi ma tetracyclines mwina sangasokoneze antibacterial zochita za ciprofloxacin. Ma microorganism omwe amalimbana ndi mankhwalawa amatha chidwi ndi ciprofloxacin. Bactericidal concentration (MBC) nthawi zambiri sikhala yochepera pazomwe zimalepheretsa kwambiri (MIC) nthawi zopitilira 2.

Kukana kwamtanda. Kutsutsa kwamphamvu pakati pa ciprofloxacin ndi antimicrobial othandizira ena m'makalasi ena sikunawonedwe.

Ciprofloxacin imagwira ntchito molimbana ndi mitundu ingapo ya mabakiteriya otsatirawa mu vitro, ndi muzipatala zamankhwala pochiza matenda.

Aerobic Gram-Positive Microorganisms : Bacillus anthracis, Staphylococcus aureus (wodwala methicillin) Staphylococcus saprophyticus, Streptococcus spp.Aerobic gram-hasi tizilombo tating'onoting'ono : Aeromonas spp., Moraxella catarrhalis, Brucella spp., Neisseria meningitidis, Citrobacter koseri, Pasteurella spp., Francisella tularensi, Salmonella spp., Haemophilus ducreyi, Shigella spp., Haemophilius influenzae, Vibri.Ma virus a Anaerobic : Mobiluncus spp .

Tizilombo tina tosiyanasiyana : Chlamydia trachomatis, Chlamydia chibayo, Mycoplasma hominis, Mycoplasma pneumoniae. Mitundu yosiyanasiyana yamphamvu ya ciprofloxacin yawonetsedwa pazinthu zotsatirazi: Acinetobacter baumann, Burkholderia cepacia, Campylobacter spp. Pseudomonas fluorescens, Serratia marcescens, Streptococcus pneumoniae, Peptostreptococcus spp., Propionibacterium acnes. Amakhulupirira kuti ciprofloxacin imagonjetsedwa mwachilengedwe. Staphylococcus aureus (methicillin zosagwira) Stenotrophomonas maltophilia, Actinomyces spp., Enteroccus faecium, Listeria monocytogene, Mycoplasma genitalium, Ureaplasma urealitycum, tizilombo toyambitsa matenda a anaerobic (kupatula Mobiluncus spp., Peptostreptococus spp., Propionibacterium acnes) .

Ndemanga za Tsifran OD

Ndemanga ya Tsifran OD ndi yabwino, zikuwonetsa kukhudzika kwakukulu kwa mankhwalawa pochiza matenda osiyanasiyana amabakiteriya.

Odwala amafotokoza kulekererana kwabwino kwa Cifran OD, kusakhalapo kwa zotsatira zoyipa, kuyambitsidwa kwachangu ndi kupweteka kwambiri.

Mlingo ndi makonzedwe

Mapiritsi ayenera kumeza popanda kutafuna, kutsukidwa ndi madzi. Amatha kumwedwa mosasamala nthawi yakudya. Ikamamwa pamimba yopanda kanthu, zinthu zomwe zimayamba kugwira ntchito zimatengedwa mwachangu.

Mapiritsi a Cifran OD amatengedwa kamodzi patsiku.

Mlingo ndi njira ya mankhwalawa zimatengera zisonyezo, kuuma ndi malo omwe matendawa ali nawo, chiwopsezo cha tizilombo toyambitsa matenda (pat )genicorganorganism (ciprofloxacin), ntchito yaimpso kwa odwala, komanso kuthandizira kwachipatala komanso mabakiteriya.

Zochizira matenda ena oyambitsidwa ndi bakiteriya (i.e. Pseudomonas aeruginosa, Acinetobacter kapena Staphylococci) ingafune Mlingo wapamwamba wa ciprofloxacin ndi makonzedwe othandizirana ndi othandizira ena okhala ndi antibacterial.

Pochiza matenda ena (mwachitsanzo, matenda am'mimba a ziwalo za m'chiberekero, matenda amkati, matenda amkati mwa odwala a neutropenic, komanso matenda am'mafupa ndi mafupa), kugwirira ntchito limodzi ndi ma antibacterial ena oyenera kungakhale kofunikira malinga ndi tizilombo toyambitsa matenda.

Kutalika kwa mankhwala (makamaka kuphatikiza chithandizo choyambirira cha makolo ndi chiprofloxacin)

Matenda ochepetsa kupuma thirakiti

Matenda opumira kwambiri a m'mapapo

Kuchulukitsa kwa matenda a sinusitis

1000 mg - 1500 mg

Matenda othandizira otitis

1000 mg - 1500 mg

Malignant otitis externa

Masiku 28 mpaka miyezi itatu

Matenda amitsempha

500 mg - 1000 mg

Mwa azimayi amisinkhu yotsalira, 500 mg (limodzi mlingo)

Cystitis yovuta, pyelonephritis yovuta

1000 mg -1500 mg

osachepera masiku 10, amatha masiku opitilira 21 chifukwa cha matenda ena akulu (mwachitsanzo, kutupira)

Masabata awiri mpaka anayi (pachimake) milungu 4 mpaka 6 (aakulu)

Matenda amtundu wa genital

Gonococcal urethritis ndi cervicitis

500 mg (muyezo umodzi)

Tsiku limodzi (mlingo umodzi)

Orchoepididymitis ndi zotupa matenda amchiberekero

1000 mg -1500 mg

osachepera masiku 14

Matenda am'mimba komanso matenda amtumbo

Kutsegula m'mimba chifukwa cha tizilombo toyambitsa matenda, incl. Shigella spp., kupatula mtundu 1 Shigella dysenteriae ndi chithandizo champhamvu cha oyenda m'mimba kwambiri

Lembani 1 m'mimba Shigella dysenteriae

Tsiku lotha ntchito:

Malo opumulira:
Kumasulidwa ndi mankhwala.

Wogwirizira Sitifiketi Yoyang'anira
Ranbaxy Laboratories Limited / Ranbaxy Laboratories Limited
Sahibzada Ajit Singh Nagar (Mohali) - 160055, (Punjab), India / Sahibzada
Ajit Singh Nagar (Mohali) - 160055, (Punjub), India
Zodandaula za ogula ziyenera kutumizidwa ku ofesi yoyimira kampani
Laboratories Limited ku adilesi: 129223, Moscow, Prospect Mira, All-Russian Exhibition Center, Business Center Technopark, yomanga 537/4, office 45-48.

Wopanga
Ranbaxi Laboratories Limited, Paonta Sahib, Dist. Sirmur 173025, Himachal Pradesh, India.
Ranbaxy Laboratories Limited, Paonta Sahib, Dist. Sirmour 173025, Himachal Pradesh, India.

Tsifran ST ndi chiyani

Malinga ndi gulu lazachipatala komanso zamankhwala, Tsifran ST ndi gulu la antimicrobials (maantibayotiki) ochokera mgulu la fluoroquinolones. Mankhwalawa m'mitundu yamapiritsi amapangidwa ndi kampani yaku India. Zosankha za CT za cyfran 250 mg ndi 500 mg zilipo. Amagulitsidwa pabokosi lamakatoni, mapiritsiwo amakhala mu mzere wopangidwa ndi aluminiyumu zojambulazo, malangizo ogwiritsidwira ntchito amawonjezeredwa. Mapiritsiwo ndi owirikiza, wachikaso pamtundu, wokhala ndi utoto.

Zogwira ntchito

Cifran ST ili ndi zida ziwiri zogwira - 250 kapena 500 mg ya ciprofloxacin hydrochloride ndi 300 kapena 600 mg ya tinidazole. Omwe amapeza ndi microcrystalline cellulose, colloidal anhydrous silicon magnesium stearate, sodium starch glycolate, sodium lauryl sulfate. Mapale akunja ali ndi sodium starch glycolate, oyeretsa talc, sodium lauryl sulfate, microcrystalline cellulose, colloidal anhydrous silicon, ndi magnesium stearate. Chipolopolocho chimakhala ndi madzi oyeretsedwa, opadra achikasu.

Ciprofloxacin

Pofuna kupondereza michere yofunika pakukula kwa mabakiteriya, ciprofloxacin imawonjezeredwa ku mankhwala antimicrobial ST Cifran. Imalepheretsa kagayidwe kachizolowezi ka causative wothandizila matendawa, imakhala ndi bactericidal momwe maselo amapumira. Mankhwalawa amakhudzidwa ndi mabakiteriya osagwiritsa ntchito gramu komanso ma gramu omwe ali ndi ma gram - awa ndi ma enterobacteria, morganella, chlamydia. Ciprofloxacin imalowa mu cell, imalepheretsa tizilombo tating'onoting'ono tomwe timatulutsa beta-lactamases.

Kuchokera kwa nitroimidazole ndi gawo la cyphran ST, lomwe limatsutsana ndi anaerobes ndi protozoa. Tinidazole imagwira, imalowa m'maselo, imawononga DNA ya mabakiteriya kapena imalepheretsa kapangidwe kake. Imapondera clostridia, peptococci, gardnerella, fusobacteria ndi matenda ena a anaerobic ambiri. Kugwiritsa ntchito tinidazole kumathandizira motsutsana ndi anaerobes osavuta kwambiri komanso ovomerezeka.

Kuchokera mapiritsi Tsifran ST

Paketi iliyonse ya mapiritsi ili ndi zidutswa 10 kapena 100 zokhala ndi malangizo ogwiritsa ntchito. Kodi Tsifran ST imagwira ntchito ndi matenda ati:

aakulu sinusitis
zotupa zam'mapapo
kuphatikiza
aakulu osteomyelitis,
zilonda zam'mimba
zironda
periodontitis, periostitis, matenda ena amkamwa
Ciprofloxacin imatha kuchiza matenda am'mimba, amoebic kapena kamwazi wosakanikirana.

Njira yamachitidwe

Tsifran yokonzekera antimicrobial yokhala ndi kaphatikizidwe kamapangidwira cholinga cha matenda osakanikirana oyambitsidwa ndi anaerobes ndi aerobes, matenda opatsirana am'mimba. Kuphatikiza kwa tinidazole ndi ciprofloxacin kumakhudza mitundu yonse iwiri ya tizilombo, kupatsanso maantibayotiki pazowoneka zosiyanasiyana. Zinthu zonse zomwe zimagwira ntchito bwino zimangokhala ndi gawo logaya chakudya, pofika pazowonjezera zingapo.

The bioavailability wa tinidazole ndi 100%, mapuloteni omanga a plasma ndi 12%. Mankhwala ophatikizidwawo amalowerera mosavuta, ndipo amalowa kwambiri. Tinidazole amapezeka mu madzi am'magazi, mankhwalawa amachotsedwa mkodzo komanso ndowe. Ciprofloxacin imalowedwa mutagwiritsidwa ntchito, bioavailability wake ndi 70%. Enanso 30% amamangiriza mapuloteni omwe amakhala m'magazi a plasma. Thupi limalowa m'mapapu, khungu, mafuta, minofu, cartilage, mafupa.

Tsifran ST mankhwala - malangizo ntchito

Mankhwala ophatikiza antimicrobial amagulitsidwa ku malo ogulitsa mankhwala, omwe amasungidwa kutentha mpaka madigiri 25 m'malo owuma, oyera, osatheka ndi ana. Moyo wa alumali ndi zaka 2. Malangizo ogwiritsira ntchito ST Tsifran ali ndi malangizo apadera:

osalembera odwala osakwanitsa zaka 12,
sinagwiritsidwe ntchito tsiku litatha,
zikaphatikizidwa ndi anticoagulants osagwirizana zimawonjezera mphamvu yawo ndi machitidwe a ethanol,
yogwirizana ndi sulfonamides, maantibayotiki, koma osagwirizana ndi ethionamide,
akaphatikizidwa ndi phenobarbital imathandizira kagayidwe,
Kugwiritsa ntchito palimodzi kumawonjezera kuchuluka kwa theophylline, osagwirizana mwachindunji, kumachepetsa index ya prothrombin,
Cifran wokhala ndi prefix ST amathandizira kuwopsa kwa cyclosporin, kumawonjezera serum creatinine,
kugwiritsa ntchito munthawi yomweyo mankhwala osapweteka a antiidal
Pamene mukumwa mapiritsiwo, pewani kuwonetsedwa kwambiri ndi dzuwa kuti mupewe kuwonongeka.
sizigwirizana ndi mowa - pali ululu, kukokana m'mimba, mseru, kusanza,
zimakhudza kuthamanga kwa kuchitapo, chifukwa chake ndizoletsedwa poyendetsa, pochita ntchito yoopsa,
kugwiritsa ntchito mankhwalawa pazifukwa zaumoyo kwa odwala omwe ali ndi khunyu, kukomoka, matenda am'mimba ndi muubongo, matenda amkati amanjenje,
kumwa mankhwalawa kuyimitsidwa ngati pali matenda otsekula m'mimba, kupweteka kwa tendon, chiwonetsero cha tendovaginitis,
Pa mankhwala opha maantibayotiki, madokotala amawunika momwe magazi amawonekera.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi. Amakutidwa ndi nembanemba wa filimu, ali ndi mawonekedwe ozungulira ndi mtundu woyera.

Mankhwalawa ali ndi 1000 mg ya mankhwala othandizira, omwe amagwiritsidwa ntchito ciprofloxacin. Kukonzekera kumakhala ndi zinthu zothandiza:

crospovidone
chipolopolo
hypopellose,
talcum ufa
isopropanol
oxide wakuda wachitsulo
silika
ammonia wamadzimadzi
sodium bicarbonate,
sodium alginate
propylene glycol
magnesium wakuba.

Mankhwalawa amapezeka ngati mapiritsi. Amakutidwa ndi nembanemba wa filimu, ali ndi mawonekedwe ozungulira ndi mtundu woyera.

Zotsatira za pharmacological

Chidacho chimakhala ndi bactericidal. Mankhwalawa amagwira ntchito osati pongofalitsa tizilombo toyambitsa matenda, komanso mabakiteriya osiyanasiyana omwe ali m'malo opanda phokoso.

Tsifran ndi yoyenera kuthetseratu matenda oyambitsidwa ndi zochita za gram-negative ndi gram-microflora.

Zomwe zimathandiza

Chida chimathandizira kulimbana ndi matenda otsatirawa:

sinusitis pachimake
kutupa kwa chikhodzodzo (cystitis),
matenda opatsirana am'mimba,
peritonitis
kutupa kutukusidwa kutulutsidwa mu ndulu,
kuwonongeka kwa aimpso tubules (pyelonephritis),
kuchuluka kwa matenda opatsirana,
bacteria bacteria prostatitis
kutupa kwa bile ducts,
chinzonono
chibayo
matenda a typhoid
mafupa a mafupa ndi mafupa, kuphatikiza matenda oopsa oopsa a mafupa,
matenda opatsirana a pakhungu.

Tsifran OD imakupatsani mwayi wolimbana ndi kutupa kwa chikhodzodzo (cystitis).

Ndi chisamaliro

Ndikofunika kulabadira zovuta zotsatirazi ndi matenda:

kulephera kwa chiwindi
matenda amitsempha yamagazi ndi mavuto ndi magazi kukapereka kwa chiwalo,
kuwonongeka kwa tendon chifukwa cha mankhwala ogwiritsa ntchito mankhwala a fluoroquinolone,
mavuto amisala
khunyu
chiwindi ntchito,
kulephera kwa aimpso.

Muzochitika izi, mankhwalawa amayikidwa mosamala.

Momwe mungatenge Cifran OD

Mankhwalawa amagwiritsidwa ntchito kamodzi pa tsiku, i.e maola 24 aliwonse.

Mankhwala ayenera kumwedwa pakamwa, kutsuka piritsi ndi kapu ya madzi oyera.

Mankhwala ayenera kumwedwa pakamwa, kutsuka piritsi ndi kapu ya madzi oyera. Dokotala akuchita dosing, chifukwa popereka mankhwala, munthu ayenera kuganizira zaka, wodwala komanso gawo la chitukuko cha matenda.

Kutalika kwa mankhwalawa kumasankhidwa chifukwa cha zovuta za matendawa. Tiyenera kukumbukira kuti njira ya mankhwalawa iyenera kupitilira kwa masiku ena awiri atatha kutha kwa zizindikiro.

Kumwa mankhwala a shuga

Panthawi yopanga matenda a shuga, mankhwalawa amagwiritsidwa ntchito malinga ndi malangizo. Musanayambe kumwa mankhwalawa, muyenera kufunsa katswiri.

Panthawi yopanga matenda a shuga, mankhwalawa amagwiritsidwa ntchito malinga ndi malangizo.

Matumbo

Kuchokera pamimba yodyera, zizindikiro zotsatirazi zingaoneke:

cholestatic jaundice
chiwindi minofu necrosis,
kuwonda
kutsegula m'mimba
chisangalalo
chiwindi
kupweteka m'mimba
kusanza ndi mseru.

Mbali ya m'mimba, zotsatira zoyipa zimatha kuoneka mwa kusanza komanso kukakamiza kusanza.

Hematopoietic ziwalo

Zotsatira zoyipa izi zitha kuchitika kuchokera ku ziwalo za hemopoietic:

hemolytic mtundu anemia,
kuchuluka kwa magazi a m'magazi,
kuchuluka kwa maselo oyera
kuchuluka kwa magazi
granulocytopenia,
leukopenia
kusintha kwa kuchuluka kwa ma eosinophils.

Pakati mantha dongosolo

Zizindikiro zotsatirazi zikuwonekera:

mutu, kuphatikizapo migraine,
kukomoka
kuwopa kuwala
kunjenjemera
kumverera kwa nkhawa
kusakhazikika
kugona kusokonezedwa
chizungulire
kuzindikira kwamasautso,
zolota
kutopa,
mavuto
kuyerekezera.

Kutenga Tsifran OD kumatha kupweteketsa mutu, kuphatikizapo migraines.

Kuchokera kwamikodzo

Zotsatira zoyipa za mkodzo zimadziwika ndi zizindikiro zotsatirazi:

kusungika kwamikodzo
magazi, kuphatikiza pa mickey
kutulutsa mkodzo wolemera
kuphwanya mkodzo,
kuwonongeka kwa aimpso glomeruli,
katulutsidwe wa mapuloteni ndi mkodzo.

Kuchokera pamtima

Mankhwalawa atha kusokoneza mtima wamthupi, chifukwa chomwe mawonetsedwe otsatirawa amachitika:

kuthamanga kwa magazi pankhope,
kuchuluka kwa mtima
kuchepetsedwa kupanikizika
kusintha kwa matenda a mtima.

Mankhwala amathandizanso kukhumudwitsa mtima, kumapangitsa kutsika kwa magazi.

Mukamagwiritsa ntchito mankhwalawa, zizindikiro zotsatirazi zoyipa ndi zotheka:

zimachitika pakhungu: matuza, kuyabwa, urticaria,
Matenda a Lyell, omwe akuimiridwa ndi zotupa, matuza okhala ndi zotupa mkati, khungu
kupuma movutikira
timabowo ting'onoting'ono
zotupa pakhungu,
malungo a mankhwala,
kutupa kwa m'mphuno ndi nkhope,
kutupa kwa khungu ndi mucous nembanemba, zikubweretsa mapangidwe owopsa exudative erythema.

Kuyenderana ndi mowa

Kumwa mowa panthawi yamankhwala kungavulaze chiwindi ndi ziwalo zina, chifukwa mankhwalawa sagwirizana bwino ndi mowa.

Gwiritsani ntchito mu ukalamba

Mankhwalawa ali contraindified mu mankhwala okalamba odwala.

Nthawi yobala mwana ndi yodziletsa kumwa mankhwalawa.
Mankhwalawa amadutsa mkaka wa m'mawere, chifukwa chake, kuti mugwiritse ntchito mankhwalawa, mwana amayenera kusamutsidwa ku mtundu wina wa chakudya kapena kusankha mankhwala ena.
Zaka 18 zakubadwa ndizotsutsana, chifukwa chake Cifran sagwiritsidwa ntchito ngati ana.
Mankhwalawa ali contraindified mu mankhwala okalamba odwala.

Momwe mungamwe Tsifran

Mapiritsi a antibacterial mankhwala Cifran wokhala ndi prefix ST amatengedwa pakamwa atatha kudya. Iyenera kutsukidwa ndi madzi osakwanira okhala ndi kaboni - pafupi ndi galasi. Sichikulimbikitsidwa kuthyolako, kutafuna piritsi. Odwala ayenera kuona kuchuluka kwa kumwa mankhwalawo, kupewa mankhwala osokoneza bongo, omwe amakhala ndi zovuta zambiri zomwe zimadutsa pamene mankhwalawo adatha.

Malinga ndi malangizo ogwiritsira ntchito Tsifran ST, mankhwalawa amagwiritsidwa ntchito mukatha kudya ndi madzi okwanira. Mlingo wovomerezeka tsiku lililonse kwa anthu azaka zopitilira 18 ndi mapiritsi awiri kawiri patsiku (mankhwala omwe ali ndi kuchuluka kwa ciprofloxacin ndi tinidazole 250/300 mg) kapena piritsi limodzi kawiri patsiku ndi mulingo wa zosakaniza 500/600 mg. Njira ya mankhwalawa imatengera kuuma kwa matendawa komanso zovuta zamatenda ndi bacteria.

Osachepera masiku atatu ayenera kupitiliza mankhwala atatha kutentha kwa thupi, ndipo nthawi yayitali idzakhala:

tsiku ndi zovuta chinzonono,
miyezi iwiri ndi osteomyelitis,
osachepera masiku 10 pamaso pa streptococci ndi chlamydia,
Popeza kuti sangathe kumwa mapiritsi pawokha ndi pakamwa, wodwalayo amalandira yankho la kulowetsedwa kudzera m'mitsempha.

Kodi ndingathe kutenga Cyfran panthawi yapakati?

Sitikulimbikitsidwa kupereka mankhwala a CT a Tsifran pa nthawi yapakati, chifukwa tinidazole amakhala ndi carcinogenic ndi mutagenic, ndipo ciprofloxacin imadutsa chikhodzodzo ndipo imakhudza kukula kwa mwana wosabadwayo. Zinthu zonse zogwira ntchito zimapezeka mkaka wa mzimayi nthawi yayitali, chifukwa chake kuyamwa sikulimbikitsidwa. CT Digital sichikuperekedwa kwa yoyamwitsa. Muyenera kusiya kuyamwitsa kapena kusankha chithandizo china.

Zomwe zimagwiritsidwa ntchito paubwana

Malangizo ogwiritsira ntchito ST Tsifran akunena kuti ndizoletsedwa kwa ana osaposa zaka 18, koma amaloledwa kugwiritsa ntchito mankhwalawa pazovuta zomwe zimayambitsidwa ndi mabakiteriya, omwe ali ndi pulmonary cystic fibrosis. Kenako mwana wazaka 5 mpaka 17 akhoza kumwa mankhwala osokoneza bongo, kusiyananso ndi kupewa ndi kuchiza matenda a pulmonary anthrax. Palibe chidziwitso pakuwerengera kwa mitundu ya ana omwe ali ndi hepatic ndi aimpso kulephera.

Mapiritsi a Cifran opuwala chiwindi ndi impso

Mosamala, tikulimbikitsidwa kutenga Tsifran ndi prefix ST ya anthu omwe ali ndi vuto lalikulu laimpso komanso chiwindi, komanso odwala okalamba. Kwa odwala oterewa, mlingo umachepetsedwa, kuphatikiza adokotala amawazindikira panthawi yonse ya chithandizo. Ndikofunikira nthawi zonse kuwunika momwe chiwindi ndi impso, chithunzi cha magazi, kupatuka pang'ono pang'ono pazomwe zimachitika.

Zotsatira zoyipa ndi contraindication

Malangizo ogwiritsira ntchito antibacterial mankhwala ST Tsifran akuwonetsa zotsutsana zotsatirazi:

Hypersensitivity zimachitikira kapena mtanda-ziwopsezo zina zotumphukira za mankhwala,
mbiri yamatenda a hematologic,
contraindicated odwala ndi chopinga wa marow hematopoiesis, ndi pachimake porphyria,
chifuwa
zotupa zamitsempha
zotupa zachilengedwe
ana ochepera zaka 18,
mosamala mu matenda a arteriosulinosis, ngozi zam'magazi, matenda amisala, khunyu.

Zotsatira zoyipa za kutenga mankhwala a Cifran ndi izi:

kutaya chilakolako, kusanza, kutsekula m'mimba, cholendatic jaundice (monga chithunzi), flatulence, hepatitis,
kupweteka mutu, chizungulire, kutopa kwambiri, mitsempha, kukokana, kukomoka, kunjenjemera, kusowa tulo,
kuchuluka kwazovuta zamkati, kukhumudwa, kusokonezeka, thrombosis, kukomoka, migraines, kuyerekezera zinthu m'magazi,
kuona kwakachepa, kumva kusamva,
tachycardia, kulephera kwa kugunda kwa mtima, kuchepa kwa magazi,
leukopenia anemia, thrombocytopenia, kuchepa magazi,
hematuria, polyuria, kwamikodzo posungira, nephritis, dysuria, kupewa crystalluria,
pruritus, generalitis urticaria, zipsera, zotupa za m'mimba,
arthralgia, nyamakazi, tendovaginitis, asthenia, myalgia, candidiasis, colitis, kupindika kwa tendon.

Zochuluka motani

Dongosolo mu pharmacy yapaintaneti ndi kutumiza kapena kugula kudzera kwa katswiri wazamankhwala amatha mapiritsi a Tsifran. Mukamagula ku Moscow ndi St. Petersburg, mutha kusankha kugwiritsidwa ntchito kwa mankhwala osakaniza. Chifukwa chake, mapiritsi 10 a 500 + 600 mg atenga ma ruble 357, ndi 250 + 300 mg palimodzi - 151 rubles. Pa intaneti, mtengowu umachepetsedwa ndi 10%, koma mtengo wotumizira ndiwowonjezera.

Ndi zinthu zomwe zimagwira, zomwe zimapangidwira muumoyo, mawonekedwe a Tsifran ST, opangidwa ndi mabizinesi aku India komanso am'nyumba, amadziwika:

mapiritsi Tsiprolet, Tsipro-TK, Tsifomed-TZ, Grandazole, Zoksan-TZ, Zoloxacin, Orzipol, Ofor, Polymik, Tifloks, Roksin, Yetat,
Grandazole kulowetsedwa njira
ufa wa Norzidime yankho,
Cephoral, Quintor, Tsiprobay.

Maxim, wazaka 23, Tsifran ST adandiwuza adotolo atazindikira kuti ndi periodontitis. Ndinatenga njira yothandizira maantibayotiki ndipo ndinazindikira kuti ikusintha - kuteteza mtima kunayamba kulira, kutukusira kunayamba kutha, ndizotheka kupitiliza chithandizo ndikuyika korona. Great bajeti mankhwala!

Nina, wazaka 30. Nditayenda paulendo, ndinapeza kamwazi. Zinali zoyipa kwambiri, dotolo adapereka mankhwala kuti athetse msanga. Adandiwuza kuchuluka kwa Tsifran, komanso mankhwala ena. Tinatha kuchotsa matendawa mu sabata limodzi.

Kuchita ndi mankhwala ena

Tsifran imadziwika ndi zotsatirazi zomwe zikugwirizana ndi mitundu ina ya mankhwala:

Kuchepetsa kuyamwa kwa zinthu zogwira ntchito mukamagwiritsa ntchito ma antacid momwe mumakhala ma aluminium hydroxide kapena magnesium hydroxide.
Kuwonjezeka kwa kuchuluka kwa mankhwala ochepetsa shuga, ma anticoagulants, xanthines ndi Theophylline.
Kuchepetsa kwamphamvu kwa ciprofloxacin pakagwiritsidwe ntchito ka didanosine.
Maonekedwe a kugona ndi kuchepa kwakuthwa kupanikizika chifukwa chogwiritsa ntchito tizanidine.
Kuwonjezeka kwa mwayi wokhala ndi zovuta zoyipa ndikamamwa mankhwala osapweteka a anti-kutupa ndi analgesics.
Anachepetsa seramu phenytoin ndende.
Kuwonjezeka kwa zovuta pa impso pa mankhwala ndi cyclosporine.
Kuwonjezeka kwa mphamvu mukamagwiritsa ntchito metronidazole, clindamycin ndi aminoglycosides.
Kuchepetsa kuchotsa kwa thupi ndi kuwonjezera kuchuluka kwa yogwira pophika mankhwala a uricosuric.
Kuthamanga kofulumira kwa cyfran chifukwa chogwiritsa ntchito metoclopramide.

Kulandila kwa Tsifran OD amadziwika ndi kuwonjezereka kwa mwayi wokhala ndi zovuta zoyipa pomwe mukumwa mankhwala osokoneza bongo a anti-kutupa ndi analgesics.

Mafuta a mankhwalawa akuphatikizapo:

Ciprobay ndi mankhwala opangidwa ndi Germany omwe amakhala ndi 250 kapena 500 mg ya ciprofloxacin.
Mapiritsi a Ciprinol okhala ndi antibacterial.
Siflox ndi mankhwala omwe ali ndi mitundu yambiri yama bacteria.
Chowonadi ndi chothandizira antibacterial momwe mankhwala othandizira ndi hemifloxacin mesylate.
Leflobact ndi mankhwala antimicrobial omwe ali ndi 250 kapena 500 mg ya levofloxacin hemihydrate. Mankhwala amalimbana ndi chlamydia, staphylococci, ureaplasma, legionella, enterococci ndi gram alibe tizilombo.
Gatifloxacin ndi antibacterial wothandizila kuchokera pagulu la fluoroquinolones. Ndi m'badwo wachinayi.
Cifran ST ndi mankhwala antimicrobial okhala ndi 500 mg ya ciprofloxacin ndi 600 mg ya tinidazole. Kupezeka ku India. Amagwiritsidwa ntchito ngati uroanaseptic mu gynecology, komanso mu mano, otolaryngology ndi madera ena a zamankhwala.

Kodi pali kusiyana kotani pakati pa Tsifran ndi Tsifran OD

Cecranarity wa Cifran OD amagwirizana ndi gawo lomwe limachepetsa pafupipafupi makonzedwe a mankhwala.

Ndemanga za madotolo ndi odwala za Tsifran OD

Evgeny Alexandrovich, katswiri wamkulu

Kugwiritsa ntchito Cifran OD kumathandiza kuthana ndi matenda opatsirana ambiri, chifukwa mabakiteriya ambiri amamva kwambiri ciprofloxacin. Mankhwalawa amadziwika ndi kuwonekera nthawi yayitali, komwe kumakhala ndi zotsatira zabwino pamankhwala abwino.

Irina, wazaka 41, Togliatti

Chifukwa cha matenda ofewa a shuga mu shuga, Cifran adalembedwa. Mankhwalawa adathandizira m'masiku ochepa kuti athe kuchepetsa zizindikirazo komanso kukula kwa kutupa. Chithandizo chinanso chinachitika kuchipatala chifukwa kuyang'aniridwa kwa achipatala kunali kofunikira. Njira yokhayo yomwe mankhwalawa amachepetsa ndi kukula kwamapiritsi, motero ndi kovuta kuwameza.

Elena, wazaka 39, Irkutsk

Mothandizidwa ndi Tsifran, OD idachotsa matendawa. Komabe, chithandizo chinali chovuta chifukwa cha mavuto, omwe anali ambiri. Atatenga piritsi loyamba, kuwawa kudawonekera mkamwa, chifukwa chakudyacho chidasandulika mayeso. Pambuyo pake chizungulire, kufooka, ndi mseru. Mankhwalawa ndi othandizadi, koma chifukwa cha zotsatira zoyipa, sindingagwiritse ntchito mankhwalawa nthawi ina.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Munthawi yonse ya chithandizo, simungathe kuchita nawo ntchito zowopsa, kuphatikizapo kayendedwe ka mayendedwe, chifukwa Tsifran OD imatha kuchepa kuthamanga kwa ma psychomotor reaction komanso chidwi.

Mimba komanso kuyamwa

Sichikulimbikitsidwa kugwiritsa ntchito Tsifran OD panthawi yapakati.

Popeza ciprofloxacin imachotsedwa mkaka wa m'mawere, ngati mukufunikira kuti mupatsane mankhwala panthawi yoy mkaka, kuyamwa kuyenera kuyimitsidwa.

Gwiritsani ntchito paubwana

Kusankhidwa kwa Tsifran OD pochiza odwala osakwana zaka 18 kumatsutsana, chifukwa mapangidwe a mafupa sanakwane.

Ndi mkhutu aimpso ntchito

Kugwiritsa ntchito kwa Cifran OD kumapangidwira odwala omwe amalephera kupweteka aimpso ndi CC ochepera 29 ml / min, kuphatikiza iwo omwe ali ndi hemodialysis ndi peritoneal dialysis.

Chenjezo liyenera kugwiritsidwa ntchito pakuchepa kwaimpso ndi CC 35-50 ml / min.

Ndi chiwindi ntchito

Mosamala, ndikofunikira kupereka Tsifran OD yovuta kwambiri chiwindi.

Gwiritsani ntchito mu ukalamba

Chenjezo liyenera kuperekedwa poika fluoroquinolones mu okalamba odwala, poganizira kuchepa kwa zaka zokhudzana ndi impso zawo, ndikuwongolera mlingo womwe ukugwirizana ndi kuchuluka kwa kuphwanya.

Pogwiritsa ntchito munthawi yomweyo Tsifran OD:

metronidazole, beta-lactams, clindamycin, aminoglycosides ndi antimicrobials ena: chifukwa synergism. Kwa chithandizo chopambana chamatenda oyambitsidwa ndi masheya a Pseudomonas, kuphatikiza kwa ceftazidime ndi azlocillin, matenda a streptococcal omwe ali ndi mankhwala a beta-lactam (meslocillin, azlocillin), matenda a staphylococcal omwe ali ndi vancomycin, isoxazolpenicillin matenda, anaerobic aminerocytamines, anaerobic aminerocytamines
theophylline: imakulitsa kuchuluka kwake m'magazi am'magazi,
tizanidine: imawonjezera chiopsezo cha kutsika kwakukulu kwa kuthamanga kwa magazi, mawonekedwe a kugona,
immunosuppress and antitumor mankhwala: kuchepetsa kuyamwa kwa cyfran OD mukamwa,
didanosine: amathandiza kuchepetsa mayamwidwe a ciprofloxacin,
Maantacid okhala ndi ma aluminium kapena magnesium hydroxide pakapangidwe: amathandizira kuchepa kwa mayamwidwe a ciprofloxacin, chifukwa chake kuphatikizaku kumatsutsana.
mankhwala omwe amatchinga katulutsidwe ka tubular, kuphatikiza phenenecid: kuchepetsa aimpso zotupa za ciprofloxacin,
analgesics: zimayambitsa zotsatira zoyipa za ciprofloxacin kuchokera ku ubongo wamkati,
phenytoin: itha kuchepa kapena kuwonjezera kuchuluka kwako kwa plasma,
sucralfate: kumachepetsa kuyamwa kwa Cyfran OD,
histamine H2 receptor antagonists: musakhale ndi chiwonetsero chachikulu pakukhudzidwa kwa bioavailability ya ciprofloxacin,
anticoagulants mkamwa, kuphatikizapo warfarin ndi zotumphukira zake: zimathandizira, chifukwa chake, akaphatikizidwa ndi mankhwala, kafukufuku wokhazikika wa njira yoyipa ya magazi amafunikira,
glyburide: imatha kuyambitsa hypoglycemia,
othandizira a hypoglycemic, caffeine ndi ma xanthines ena: kuwonjezera kuchuluka kwawo ndikukuza T1 / 2,
metoclopramide: imathandizira mayamwa,
othandizira uricosuric: pafupifupi 50% imachepetsa kuchotsedwa kwa kuprofloxacin, ndikuwonjezera kuchuluka kwa plasma ndende,
cyclosporine: imawonjezera mphamvu yake ya nephrotoxic. Popeza pali kuchuluka kwa serum creatinine, mulingo wake uyenera kuyendetsedwa kawiri pa sabata.

Migwirizano ndi machitidwe osungidwa

Pewani kufikira ana.

Sungani ku kutentha mpaka 25 ° C m'malo owuma.

Moyo wa alumali ndi zaka 2.

Mankhwala Okhala Pamalo a Pharmacy

Yoperekedwa ndi mankhwala.

Ndemanga za Tsifran OD

Ndemanga ya Tsifran OD ndi yabwino, zikuwonetsa kukhudzika kwakukulu kwa mankhwalawa pochiza matenda osiyanasiyana amabakiteriya.

Odwala amafotokoza kulekererana kwabwino kwa Cifran OD, kusakhalapo kwa zotsatira zoyipa, kuyambitsidwa kwachangu ndi kupweteka kwambiri.

Mtengo wa Tsifran OD m'masitolo ogulitsa mankhwala

Mtengo wa Tsifran OD 1000 mg pa paketi iliyonse yokhala ndi miyala 10 ikhoza kukhala ma ruble 267-325. Mapiritsi 10 a Tsifran OD 500 mg amatenga ma ruble 170-206.

Makhalidwe wamba. Zopangidwa:

Mapiritsi, okutira, osakhalitsa, mu tebulo limodzi.
ciprofloxacin 500 mg, 1000 mg
mu chithuza 5 ma PC., mumapaketi okhala ndi makatoni 1 kapena 2 matuza.

Kufotokozera Mapale "Tsifran® OD 500 mg": chowulungika, kuyambira oyera mpaka pafupi oyera, okhala ndi mafilimu, osindikizidwa ndi inki yakuda yakudya - "Cifran OD 500 mg".
Mapiritsi a Cifran® OD 1000 mg: chowulungika, kuyambira choyera mpaka pafupifupi choyera, yokutidwa ndi kanema, chosindikizidwa ndi inki yakuda ya chakudya - Cifran OD 1000 mg.

Zomwe Mungagwiritse Ntchito:

Mwa odwala ena omwe amalandira fluoroquinolones, mawonekedwe a photosensitivity adawonedwa. Kuwonetsedwa kwambiri ndi dzuwa mwachindunji ndi ma radiation a UV kuyenera kupewedwa. Ngati chithunzi cha photosensitivity chachitika, tikulimbikitsidwa kusiya kugwiritsa ntchito mankhwalawa. Popeza Cifran® OD ndi mankhwala okhala ndi vuto la kusintha kwa impso, sizikulimbikitsidwa kuti mugwiritse ntchito kwa odwala omwe ali ndi vuto laimpso, ndi Cl creatinine

Tsifran OD - mankhwala a nthawi yayitali, mapiritsi a chipolopolo. Dzinalo lomwe limatengedwa ku ntchito zamankhwala zapadziko lonse ndi ciprofloxacin.

Kufotokozera ndi mankhwala

Mankhwalawa amaperekedwa ngati mapiritsi oyera. Iliyonse imakutidwa ndi kanema. Pa dzanja limodzi pali chizindikiro - Cifran ODSOOMG. Inki ya chakudya imagwiritsidwa ntchito polemba. Pozikanda, piritsi limatha kusintha pang'ono.

Izi ndizofunikira! Kuchita kwa mankhwalawa ndikufuna kuwononga microflora (mabakiteriya) osiyanasiyana. Mankhwala ndi mankhwala a matenda a matenda.

Mankhwala mawonekedwe - mapiritsi, mmatumba a matuza a 5 zidutswa. Mu bokosi 1 kapena 2 matuza.

Chithandizo chophatikizika cha mankhwalawa ndi ciprofloxacin.

"Tsifran OD" (500 mg) - ili ndi 500 mg pazomwe zimagwira,
"Tsifran OD" (1000 mg) - 1000 mg ya mankhwala othandizira.

Alginate ndi sodium bicarbonate,
Magnesium wakuba,
Talc,
Silika

Zomwe zimapangidwa ndi chipolopolo:

Mapiritsi amagwiritsidwa ntchito ngati chithandizo cha matenda a pathologies oyambitsidwa ndi tizilombo:

Sinusitis
Matenda am'mapapo amtundu wa matenda opatsirana, omwe amakhala ndi kutupa,
Mitundu yosiyanasiyana ya cystitis, pyelonephritis,
Matenda a prostatitis a bacteria,
Gonorrhea
Matumbo a m'mimba omwe amapezeka ndi zovuta (chithandizo chazimba zimayikidwa limodzi ndi metronidazole),
Njira zachikhalidwe pakhungu la chilengedwe,
Njira zopatsirana zamatenda ophatikizika ndi mafupa,
Matenda a Stool omwe amayamba chifukwa cha matenda,
Matenda a typhoid,
Cholecystitis.

Kutenga mankhwalawa m'magulu apadera a odwala

Ndi kuwonongeka kwakukulu kwa impso.

Ndi zovuta zazing'ono mthupi, theka la moyo wogwira ntchito limakulirakulira. Popeza izi, dokotala amayenera kusintha kuchuluka kwa mankhwalawa komanso kutalika kwa nthawi ya maphunzirowa.

Ndi chiwindi ntchito.

Kafukufuku anachitika mu odwala a matenda amitsempha, kusintha kwakukulu pamankhwala sikunawonedwe. Popereka mankhwala, muyenera kukumbukira kuti palibe maphunziro omwe adachitidwa kwa odwala omwe ali ndi vuto la chiwindi.

Tsifran OD ndi pakati.

Popeza kuti amatha kugwiritsa ntchito mankhwalawa, kutenga Cifran OD pa nthawi yoyembekezera komanso mkaka wa m'mawere sikulimbikitsidwa.

Izi ndizofunikira! Pa nthawi yoyamwitsa, kuikidwa kwa mankhwalawo ndikotheka ngati chiwopsezo cha moyo wa mayi chikukwera kuposa chiwopsezo kwa mwana, koma kuyamwitsa kuyenera kuyimitsidwa.

Zotsatira zoyipa

Ziwalo zogaya:

Khansa yapakhungu (nthawi zina, kusanza)
Zosokoneza pampando
Kusavutika ndi kutulutsa m'mimba,
Kumva kutumphuka m'mimba
Anorexia
Hepatitis
Ngati wodwala wadwala matenda a chiwindi, zizindikiro za jaundice zimatha kuonekera.

Machitidwe amanjenje:

Kuopa kuwalako
Zosokoneza tulo
Kusakwiya
Chizungulire
Kutopa
Kumva nkhawa
Kusokonezeka kwa malingaliro
Zovuta.

Zosangalatsa:

Lawani kusokonekera,
Kusokoneza kwamitundu
Fungo lamphamvu
Makutu owonjezera m'makutu.

Dongosolo la mtima:

Tachycardia,
Zapanikizika,
Kukutira nkhope
Kufika pamtima kumadumpha.

Dongosolo la Hematopoietic:

Leukocytosis
Anemia
Leukopenia
Eosinophilia.

Njira zamankhwala:

Nephritis mu pachimake gawo (nthawi zina, aimpso kulephera),
Hematuria
Dysuria
Kusungika kwamikodzo mthupi,
Albuminuria

Ziwengo:

Kuyenda ndi ming'oma
Matumba akuwoneka kuti amatuluka limodzi ndi magazi,
Zopanda zotupa ndi zopindika zazing'ono zimawonekera,
Pakhungu, miloza mawonekedwe
Nthawi zina, kutupira nkhope ndi m'mimba zimatheka,
Kupuma pang'ono
Vasculitis
Mitundu yosiyanasiyana ya erythema,
Necrolysis.

Makina a minofu ndi mafupa:

Nyamakazi
Myalgia
Arthralgia,
Tenovaginitis.

Izi ndizofunikira! Nthawi zina, odwala amatuluka thukuta kwambiri, kufooka,

Kuchita ndi mankhwala ena

Mukalandira chithandizo cha Cifran OD ndi glucocorticosteroids, odwala azaka zopitilira 60 amathandizira kwambiri kuwonongeka kwa tendon.
Mankhwala omwe amalimbikitsa mkodzo wamkodzo akaperekedwa limodzi ndi Cifran OD, mwayi wa nephrotic umachulukana.
Pali chiwopsezo chachikulu chowonetsedwa cha zotsatira za neurotoxic pomwe chithandizo ndi Cifran OD ndi mankhwala ena osapweteka a antiidal.
Ndikofunikira kuti pakhale nthawi yopuma pakati pa ma antacid, mankhwala omwe amachokera pazitsulo ndi cyfran OD. Kupuma kochepa ndi maola awiri, apo ayi kugwiritsa ntchito bwino kwa mankhwalawa kumachepa kwambiri.
Zogulitsa zimakhudza kuyipa kwa chogwira ntchito.

Zoyenera kuyang'ana

Odwala omwe adalandira fluoroquinol chithandizo adawonetsa kuwonjezeka kwa photosensitivity. Panthawi yamankhwala, muyenera kuchepetsa kuyatsidwa ndi kuwala kwa dzuwa ndi ma radiation a ultraviolet. Ngati chiwopsezo cha kuunika chikuwonjezeka kwambiri, dokotala akuganiza zochepetsa mlingo kapena kuletsa mankhwalawo, ndikusinthanso ndi mankhwala ena.

Tsifran OD imasinthanso poizoni. Sitikulimbikitsidwa kupereka mapiritsi a:

Matenda a impso,
Hemodialysis
Kudina.

Tsifran OD imatha kupangitsa kuti pseudomembranous colitis. Njira zamatsenga zimatha kuchitika mofatsa kapena m'njira yomwe ingawopseze moyo wa wodwalayo. Ngati chithandizo cha mankhwala chikuphatikizidwa ndi matenda otsekula m'mimba otenga nthawi yayitali, ngati mavuto am'mimbamo amayamba pambuyo pake, maphunziro amafunika kuchitidwa kuti apewe kukayikira kwa pseudomembranous colitis. Ngati matendawa atsimikiziridwa, ndikofunikira kuletsa Tsifran OD ndikuwonetsa monga chithandizo.

Kupatula mwayi wokhala ngati crystalluria, simungathe kupitilira zovomerezeka ndikumwa madzi ambiri munthawi yonse ya mankhwala.

Mankhwalawa amalangizidwa pazifukwa zaumoyo, ngati wodwala ali:

Khunyu
Zingwe
Matenda a mtima
Kuwonongeka kwa ubongo.

Izi matendawa zimatha kuyambitsa zotsatira zoyipa zamagetsi.

Muzochita zachipatala, pali milandu ya kuvulala kwa tendon pomwe mankhwala a fluoroquinol adalembedwa. Pazizindikiro zowopsa - kusapeza bwino pa tendons ndi zizindikiro za tenosynovitis - muyenera kufunsa katswiri kuti musinthe mlingo kapena muthane ndi mankhwalawo.

Izi ndizofunikira! Pazaka zamankhwala, munthu ayenera kuchepetsa kuyatsidwa ndi dzuwa ndikusankha mtundu wa zochitika zomwe zimafunikira ndikuwongolera oyendetsa mayendedwe.

Kusunga ndi moyo wa alumali

Mankhwalawa amasungidwa pamatenthedwe mpaka madigiri a +25, m'malo amdima ndi owuma. Tsifran OD imakhalabe yogwira ntchito kwa chaka chimodzi.

Basigen - kuchokera ma ruble 15,
Ciprofloxacin - kuchokera ma ruble 17,
Ciprofloxacin AKOS - kuchokera ma ruble 20,
Ciprofloxacin Bufus - kuchokera ma ruble 25,
Ciprofloxacin SOLOpharm - kuchokera ku ma ruble 30.

Zomwe madotolo amakamba za mankhwalawa.

Nikolai Petrovich, wothandizira: ndimapereka mankhwala a purulent-yotupa a metabolism. Zotsatira zamankhwala zimawonekera tsiku loyamba. Ndimapereka mankhwala a cifran OD ngati chithandizo, komanso prophylaxis musanachite opareshoni. Zokhudza zolakwika - piritsi ndi lalikulupo, ndikovuta kumeza.

Olga Petrovna, dokotala wazachipatala: Poyerekeza ndi mankhwala ena a antibacterial, Tsifran OD ili ndi zotetezeka kwambiri, zotsatira zoyipa zochepa zimawonekera. Ndikufuna kudziwa kuyendetsa bwino mapiritsi. Ngati pali umboni woyenera, ndi Tsifran OD yemwe amasankhidwa woyamba.

Zomwe odwala akunena za mankhwalawa.

Vera, wazaka 39: Tsifran OD wophatikizidwa ndi Smartprost anathandiza mwamuna wanga ku prostatitis.

Oksana, wa zaka 28: Tikuthokoza kwambiri kwa dotolo yemwe anapulumutsa mwana wanga kuchipatala ndi chibayo cham'mbali ziwiri. Adasankha Tsifran OD, ndipo patatha masiku atatu, mwana wake wamwamuna adayamba kuchira, ndipo patatha milungu iwiri kuwombera kwa mapapu kumawonetsa kuti kuwopsa kwatha.

Nikita, wazaka 57: Ndinkamwa mankhwalawo ndikumwa zilonda, kutentha kumatha kubwereranso kwamadzulo. Komabe, Tsifran OD idandiyambitsa mavuto - mkamwa youma, kupweteka mutu, kumva kufoka.