Galvus analogues
Galvus (mapiritsi) Kutalika: 208
Galvus ndi piritsi lokonzekera mankhwalawa a mtundu 2 a shuga omwe amachokera ku vildagliptin mu mlingo wa 50 mg. Itha kuthandizidwa monga monotherapy komanso ngati gawo limodzi la mankhwala othandizira pakakhala zovuta kudya komanso kuchita masewera olimbitsa thupi.
Mndandanda wa mankhwala Galvus
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 981.
Onglisa ndi mankhwala aku America pochiza matenda a shuga 2 omwe amachokera pa saxagliptin mu gawo la 2,5 kapena 5 mg. Amawonjezera kuwonjezera pa zolimbitsa thupi ndi zakudya kuti azitha kusintha glycemic control.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 857.
Wopanga: Beringer Ingelheim (Austria)
Kutulutsa Mafomu:
- Mapiritsi a 5 mg, ma PC 30., Mtengo kuchokera ku ma ruble 1648
Malangizo ogwiritsira ntchito
Trazhenta - mankhwala a ku Austria opangidwa pochiza matenda a shuga 2, angathe kuikidwa onse ngati mankhwala osokoneza bongo. Chokhacho chokhacho chophatikizidwa ndi linagliptin mu mlingo wa 5 mg. Trazenta sinafotokozeredwe mtundu woyamba wa matenda ashuga, pa nthawi yoyembekezera, mkaka wa m'mawere, komanso mwa ana osakwana zaka 18.
Analogue ndiokwera mtengo kwambiri kuyambira 1418 rubles.
Wopanga: Merck Sharp ndi Dome (USA)
Kutulutsa Mafomu:
- Mapiritsi 100 mg, 28 ma PC., Mtengo kuchokera ku ma 900 rubles
Malangizo ogwiritsira ntchito
Januvia ndi mankhwala ku America a matenda ashuga. Zogwira pophika: sitagliptin (mwanjira ya phosphate monohydrate) 100 mg. Itha kugwiritsidwa ntchito ngati kuwonjezera pa zolimbitsa thupi ndi zakudya kuti muchepetse shuga.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 182.
Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:
- Tab. 12,5 mg, 28 ma PC., Mtengo kuchokera ku ma ruble 973
- Tab. 25 mg, 28 ma PC., Mtengo kuchokera ku ma ruble a 1282
Malangizo ogwiritsira ntchito
Vipidia ndi othandizira a hypoglycemic pamapiritsi okhala ndi alogliptin. Amapereka kuchepa kwa glycosylated hemoglobin ndi glucose. Amasonyezedwa ngati pali mtundu wa shuga wachiwiri wa mtundu wa 2 mellitus mu mawonekedwe a monotherapy, komanso kuphatikiza mankhwala ndi ena othandizira a hypoglycemic. Mlingo woyenera ndi 25 mg / tsiku, amatengedwa mosasamala chakudya. Wolemba matenda ashuga ketoacidosis, mtundu 1 shuga mellitus, mtima kulephera, aimpso ndi chiwindi kulephera. Zotsatira zoyipa zingaphatikizepo kupweteka kwa mutu, kupweteka kwa epigastrium, zotupa, matenda opatsirana a ziwalo za ENT. Ana ochepera zaka 18 ndi amayi apakati samayikidwa chifukwa chosowa chidziwitso pazomwe zimachitika.
Analogs mwa chisonyezo ndi njira yogwiritsira ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Onglisa saxagliptin | 1472 rub | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Rosiglitazone wothandiza, metformin hydrochloride | -- | -- |
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 rub | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 rub | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 rub | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Fomu metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Forethine | 37 rub | -- |
| Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc | 26 rub | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Metformin-teva metformin | 43 rub | 22 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
| Glibenclamide Glibenclamide | 30 rub | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeteson MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 44 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 rub | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Guwa | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Wokongola | -- | -- |
| Glimepiride glimepiride | 27 rub | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 rub | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Glamepiride diamerid | 2 rub | -- |
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 rub | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 rub | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 rub | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 rub | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Lixumia lixisenatide | -- | 2498 UAH |
| Malo a Guarem Guar | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 rub | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 rub | 3200 UAH |
| Invocana canagliflozin | 13 rub | 3200 UAH |
| Jardins Empagliflozin | 222 rub | 566 UAH |
| Trulicity Dulaglutide | 115 rub | -- |
Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?
Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.
Malangizo a Galvus
Kupanga
1 tabu. Muli vildagliptin 50 mg,
zotuluka: MCC, anactrous lactose, sodium carboxymethyl starch, magnesium stearate,
Kulongedza
mu phukusi la ma 14, 28, 56, 84, 112 ndi 168 ma PC.
Zotsatira za pharmacological
GALVUS - vildagliptin - nthumwi ya kalasi ya zopititsa patsogolo ziwiya za kapamba, mosamala ziletsa ma enzyme dipeptidyl peptidase-4 (DPP-4). Kulepheretsa mwachangu komanso kwathunthu kwa ntchito ya DPP-4 (> 90%) kumayambitsa kuwonjezeka kwa kubisa komanso kokhala ndi chakudya komwe kumapangitsa mtundu wa 1 glucagon-peptide (GLP-1) ndi glucose-wodalira insulinotropic polypeptide (HIP) kuchokera kumatumbo kulowa kutsekemera kwazinthu tsiku lonse.
Kuchulukitsa milingo ya GLP-1 ndi HIP, vildagliptin kumayambitsa kukhudzika kwa pancreatic? Maselo ku glucose, omwe amatsogolera pakukonzanso katulutsidwe ka insulin. Mukamagwiritsa ntchito vildagliptin pa mlingo wa 50-100 mg / odwala omwe ali ndi vuto lachiwiri la matenda a shuga, kusintha kwa kapangidwe ka mankhwala kapamba kumadziwika. Kuchuluka kwa kusintha kwa ntchito? -Cell imatengera kuchuluka kwa kuwonongeka kwawo koyambirira, kotero, mwa anthu omwe alibe matenda a shuga (chifukwa cha shuga wamagazi), vildagliptin simalimbikitsa kutulutsa kwa insulin ndipo sikuchepetsa shuga.
Potukula miyezo ya am'kati mwa GLP-1, vildagliptin imawonjezera chidwi cha β-cell ku glucose, zomwe zimabweretsa kusintha kwa kayendetsedwe kamatenda a glucagon. Kutsika kwa glucagon ochulukirapo panthawi ya chakudya, kumayambitsa kuchepa kwa insulin.
Kuwonjezeka kwa kuchuluka kwa insulin / glucagon motsutsana ndi maziko a hyperglycemia, chifukwa cha kuchuluka kwa GLP-1 ndi HIP, kumayambitsa kuchepa kwa kupanga kwa chiwindi ndi chiwindi nthawi yonse ya chakudya ndikatha kudya, zomwe zimayambitsa kuchepa kwa shuga m'magazi.
Kuphatikiza apo, pogwiritsa ntchito vildagliptin, kuchepa kwa milomo ya lipids m'magazi amwazi kumadziwika, komabe, izi sizikugwirizana ndi zomwe zimakhudzidwa ndi GLP-1 kapena HIP komanso kusintha kwa ntchito ya pancreatic?
Amadziwika kuti kuwonjezeka kwa GLP-1 kumatha kuchepetsa m'mimba, koma izi sizikuwoneka ndi kugwiritsa ntchito vildagliptin.
Mukamagwiritsa ntchito vildagliptin mu 5795 odwala omwe ali ndi mtundu wa 2 shuga mellitus kwa masabata 12 mpaka 52 monga monotherapy kapena osakanikirana ndi metformin, zotumphukira za sulfonylurea, thiazolidinedione, kapena insulin, kuchepa kwakukulu kwakanthawi kwakanthawi kwa kuchuluka kwa glycated hemoglobin (HbA1c) komanso kusala glucose.
Galvus, zikugwiritsa ntchito
Type 2 matenda a shuga:
- monga monotherapy kuphatikiza mankhwala ochizira komanso masewera olimbitsa thupi,
- monga gawo limodzi la magawo awiri ophatikizira mankhwala ndi metformin, zotumphukira za sulfonylurea, thiazolidinedione kapena insulini pang'onopang'ono chifukwa chokhala ndi mphamvu ya kudya, kuchita masewera olimbitsa thupi komanso monotherapy ndi mankhwalawa.
Contraindication
Hypersensitivity to vildagliptin ndi zina zilizonse za Galvus,
ana ochepera zaka 18 (mphamvu ndi chitetezo sizinakhazikitsidwe).
Ndi chisamaliro:
kuphwanya kwambiri chiwindi, kuphatikiza odwala omwe ali ndi zochitika zambiri za michere ya chiwindi (ALT kapena AST> 2,5 nthawi zambiri kuposa malire apamwamba - 2,5 × VGN),
kuwonongeka kwakanthawi kapena kupweteka kwambiri kwa impso (kuphatikiza CRF yotsitsa pa hemodialysis) - luso logwiritsira ntchito ndilochepa, mankhwalawa ali osavomerezeka m'gulu lino la odwala.
matenda abwinobwino obadwa nawo - galactose tsankho, kuchepa kwa lactase kapena malabsorption a shuga-galactose.
Mlingo ndi makonzedwe
Galvus amatengedwa pakamwa, ngakhale chakudyacho.
Mlingo wa mankhwalawa wa mankhwalawa uyenera kusankhidwa payekha kutengera momwe umagwirira ntchito komanso kulolera.
Mlingo wovomerezeka wa mankhwalawa panthawi ya monotherapy kapena ngati gawo limodzi la mankhwala ophatikizika awiri, metazin, thiazolidinedione kapena insulin ndi 50 kapena 100 mg kamodzi patsiku. Odwala omwe ali ndi matenda oopsa a 2 omwe alandila chithandizo cha insulin, Galvus amalimbikitsidwa pa 100 mg / tsiku.
Mlingo wa 50 mg / tsiku uyenera kutumikiridwa mu 1 mg m'mawa, mlingo wa 100 mg / tsiku - 50 mg kawiri pa tsiku m'mawa ndi madzulo.
Mimba komanso kuyamwa
Mu kafukufuku woyeserera, pamene adafotokozedwa mu Mlingo wowirikiza 200 kuposa momwe analimbikitsira, mankhwalawa sanayambitse chimbudzi ndikukula kwa mluza ndipo sanatulutse mphamvu ya mwana wosabadwa. Palibe deta yokwanira yogwiritsira ntchito mankhwalawa Galvus mwa amayi apakati, chifukwa chake mankhwalawa sayenera kugwiritsidwa ntchito panthawi yoyembekezera. Mu vuto la metabolism wamagazi mwa amayi apakati, pamakhala chiwopsezo chodzala ndi mavuto obadwa nawo, komanso kufalikira kwamatenda a kubadwa kwa neonatal.
Popeza sizikudziwika ngati vildagliptin yokhala ndi mkaka wa m'mawere idachotsedwa mwa anthu, Galvus sayenera kugwiritsidwa ntchito pa mkaka wa mkaka.
Zotsatira zoyipa
Mukamagwiritsa ntchito Galvus ngati monotherapy kapena kuphatikiza mankhwala ena, zovuta zambiri sizinali zofatsa, zosakhalitsa, ndipo sizinafune kusiya kwa mankhwalawa. Palibe kulumikizana komwe kunapezeka pakati pa pafupipafupi pazochitika zoyipa (AE) ndi zaka, jenda, mtundu, nthawi yogwiritsira ntchito, kapena mtundu wa dosing. Zovuta za angioneurotic edema pamankhwala a Galvus anali ≥1 / 10,000. Kutengera komwe kumachitika pakumchira ndi Galvus, kukanika kwa chiwindi (kuphatikiza hepatitis) komanso maphunziro asymptomatic sizinawonekere. Nthawi zambiri, izi kuphwanya ndi kupatuka kwa chiwindi ntchito indices kuchokera munthawi zonse anakambirana popanda zovuta pambuyo kusiya ntchito mankhwala. Mukamagwiritsa ntchito Gal Gal mankhwala mu 50 mg 1 kapena 2 pa tsiku, pafupipafupi kuchuluka kwa michere ya chiwindi (ALT kapena AST ≥3 × VGN) inali 0,2 kapena 0,3%, motero (poyerekeza ndi 0,2% pagulu lolamulira) . Kuwonjezeka kwa ntchito ya ma enzymes a chiwindi nthawi zambiri kunali asymptomatic, sikunapite patsogolo, ndipo sikunayendetsedwe ndi kusintha kwa cholestatic kapena jaundice.
Malangizo apadera
Nthawi zina, mukamagwiritsa ntchito vildagliptin, kuwonjezeka kwa zochitika za aminotransferase kumadziwika (nthawi zambiri popanda mawonekedwe a chipatala). Musanalembe mankhwala ndi chaka choyamba chamankhwala (1 nthawi mu miyezi 3), tikulimbikitsidwa kudziwa magawo amomwe amachititsa chiwindi kugwira ntchito. Ndi kuwonjezeka kwa ntchito za aminotransferases, zotsatira zake ziyenera kutsimikiziridwa ndi kafukufuku wobwerezabwereza, ndipo nthawi ndi nthawi muzitsimikizira magawo a michere ya chiwindi mpaka atasintha. Ngati kuchuluka kwa ntchito ya AST kapena ALT ndikokwera katatu kuchulukitsa kuposa momwe malirewo amatsimikizidwira ndi kafukufuku wachiwiri, tikulimbikitsidwa kuletsa mankhwalawo. Ndi chitukuko cha jaundice kapena zizindikiro zina zokhudzana ndi chiwindi ntchito, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo osakonzedwanso pambuyo podziwonetsa zizindikiro za chiwindi. Ngati chithandizo cha insulin chikufunika, vildagliptin imagwiritsidwa ntchito limodzi ndi insulin. Mankhwala sayenera kugwiritsidwa ntchito ngati matenda a shuga 1 kapena mankhwalawa a matenda ashuga a ketoacidosis. Munthawi yamankhwala (ndi chizungulire), ndikofunikira kupewa magalimoto oyendetsa galimoto ndikuchita zinthu zoopsa zomwe zimafuna kuti anthu azisamalira komanso azithamanga kwambiri.
Kuyanjana kwa mankhwala osokoneza bongo
Galvus ali ndi mwayi wotsika wolumikizana ndi mankhwala. Popeza Galvus si gawo laling'ono la ma enzymes a cytochrome P450, komanso sikulepheretsa kapena kuyambitsa ma enzyme awa, kuyanjana kwa Galvus ndi mankhwala omwe ali apansi, zoletsa, kapena inducers a P450 sizokayikitsa. Pogwiritsa ntchito nthawi yomweyo vildagliptin sikukhudzanso kuchuluka kwa kagayidwe kazakudya kamene kamakhala mu ma enzyme: CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 ndi CYP3A4 / 5.
Bongo
Zizindikiro mukamagwiritsa ntchito mankhwala a 400 mg /, kupweteka kwamisempha kumatha kuchitika, kawirikawiri - mapapu ndi kuchepa kwa kanthawi kochepa, kutentha thupi, edema komanso kuwonjezeka kwapang'onopang'ono kwa ndende ya lipase (2 times kuposa VGN). Ndi kuwonjezeka kwa mlingo wa Galvus mpaka 600 mg /, chitukuko cha edema cha malekezero okhala ndi paresthesias ndi kuwonjezeka kwa kuchuluka kwa CPK, ALT, protein-m-protein komanso myoglobin ndizotheka.Zizindikiro zonse za mankhwala osokoneza bongo komanso kusintha kwa magawo a ma laboratite amatha pambuyo pakutha kwa mankhwalawa.
Chithandizo: Kuchotsa kwa mankhwala kuchokera mthupi kudzera mu dialysis ndikosatheka. Komabe, hydrolytic metabolite yayikulu ya vildagliptin (lay151) imatha kuchotsedwa m'thupi ndi hemodialysis.
Malo osungira
Pamalo amdima pakutentha kosaposa 25 ° C.
Othandizira a Galvus Othandizira Mapale
Vipidia (mapiritsi) Kukala: 88 Pamwamba
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 182.
Vipidia ndi othandizira a hypoglycemic pamapiritsi okhala ndi alogliptin. Amapereka kuchepa kwa glycosylated hemoglobin ndi glucose. Amasonyezedwa ngati pali mtundu wa shuga wachiwiri wa mtundu wa 2 mellitus mu mawonekedwe a monotherapy, komanso kuphatikiza mankhwala ndi ena othandizira a hypoglycemic. Mlingo woyenera ndi 25 mg / tsiku, amatengedwa mosasamala chakudya. Wolemba matenda ashuga ketoacidosis, mtundu 1 shuga mellitus, mtima kulephera, aimpso ndi chiwindi kulephera. Zotsatira zoyipa zingaphatikizepo kupweteka kwa mutu, kupweteka kwa epigastrium, zotupa, matenda opatsirana a ziwalo za ENT. Ana ochepera zaka 18 ndi amayi apakati samayikidwa chifukwa chosowa chidziwitso pazomwe zimachitika.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 857.
Trazhenta - mapiritsi ochepetsa magazi. Zimakhazikitsidwa ndi molekyule ya linagliptin. Amachepetsa kupanga shuga m'magazi, amatulutsa shuga m'magazi. Matenda a shuga a Type 2 ndi chizindikiro chogwiritsidwa ntchito mwa mtundu wa monotherapy komanso chithandizo chamankhwala pamodzi. Kusankha kwa payekha ndi payekha. Sikugwira ntchito pa matenda a mtundu woyamba 1, kudziwa za munthu, matenda ashuga a ketoacidosis. Zotsatira zosafunikira zitha kukhala kutsokomola, kapamba, kuchulukana kwammphuno. Sikugwiritsidwa ntchito mwa ana ochepera zaka 18 ndi amayi apakati.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 981.
Onglisa - mankhwala ochizira matenda a shuga. Zomwe zimagwira mapiritsiwo ndi saxagliptin. Amachepetsa glucagon, shuga wa m'magazi musanadye komanso pambuyo pake. Amawerengetsera mtundu wa matenda a shuga a 2 monga kuwonjezera kwa zakudya mu mawonekedwe a monotherapy komanso kuphatikiza. Mlingo kusuntha kumadalira zikuwonetsa. Mtundu woyamba wa matenda a shuga a mellitus, makonzedwe a insulin, ketoacidosis ndi contraindication. Kutupa, mutu, mphuno, zilonda zapakhosi ndizotheka ndi chithandizo cha Onglisa. Panalibe chidziwitso mu ana ndi amayi apakati, chifukwa chake, sichikugwiritsidwa ntchito pagululi.
Analogue ndiokwera mtengo kwambiri kuyambira 1418 rubles.
Januvia ndi mankhwala enanso a hypoglycemic okhala ndi sitagliptin. Zimawononga kwambiri kuposa Galvus ndi nambala yofanana ya mapiritsi omwe ali phukusi. Amachepetsa kupanga glucagon, amachepetsa glycemia. Amagwiritsidwa ntchito kokha mtundu wa 2 shuga. Mlingo umasinthidwa molingana ndi kuchuluka kwa shuga m'magazi. Sigwiritsidwa ntchito pa matenda a shuga 1, hypersensitivity. Mutu, kutsegula m'mimba, kunyansidwa, kupweteka kwapakati, matenda am'mapapo am'mimba amapezeka panthawi ya chithandizo. Monga mankhwala omwe ali pamwambapa, samalandira ana ochepera zaka 18 ndi amayi apakati.
Galvus Met
Metformin ndi mankhwala padziko lonse lapansi a matenda ashuga 2, amawerengedwa pafupifupi kwa odwala onse. Kwa nthawi yayitali yogwiritsira ntchito, sikuti mphamvu ya mankhwalawa yokha idatsimikiziridwa, komanso adapeza zotsatira zambiri zabwino pamtima, mitsempha yamagazi, magazi a lipid. Malinga ndi malingaliro a mayanjano a odwala matenda ashuga, mankhwala ena amaikidwa pokhapokha ngati metformin sikokwanira kulipiritsa anthu odwala matenda ashuga.
Mapiritsi a Galvus Met amaphatikizidwa, amakhala ndi metformin ndi vildagliptin. Kugwiritsa ntchito mankhwalawa kumatha kuchepetsa kuchuluka kwa mapiritsi, zomwe zikutanthauza kuti kumachepetsa mwayi wosowa mmodzi wawo. Zoyipa za mankhwalawa ndizokwera mtengo pochizira poyerekeza ndi mtundu wina wa Galvus ndi metformin.
| Mlingo Galvus Met, mg | Mtengo wamba wa ma tabu 30, ma ruble. | Mtengo wa mapiritsi 30 a Galvus ndi Glucofage yemweyo mlingo, ma ruble. | Kukweza mtengo,% |
| 50+500 | 1550 | 875 | 44 |
| 50+850 | 890 | 43 | |
| 50+1000 | 950 | 39 |
Analogs ndi choloweza
Popeza Galvus ndi mankhwala atsopano, chitetezo cha patent chimagwiranso ntchito kwa iye. Opanga ena sangathe kupanga mapiritsi okhala ndi zinthu zomwezo, zinthu zotchipa zapakhomo sizipezeka.
DPP-4 zoletsa komanso ma incretin mimetics atha kukhala ngati a Galvus m'malo:
- sitagliptin (Januvius, Xelevia, Yasitara),
- saxagliptin (Onglisa),
- exenatide (Baeta),
- liraglutide (Viktoza, Saksenda).
Onsewa ndi okwera mtengo, makamaka Baeta, Viktoza ndi Saksenda. Chithandizo chokhacho cha Russia pamwambapa ndi Yasitar kuchokera ku Pharmasintez-Tyumen. Mankhwalawa adalembetsedwa kumapeto kwa chaka cha 2017, sichikupezeka mumafakisi.
Wodwala akatsatira zakudya, amatenga Galvus Met pamlingo wambiri, ndipo shuga akadali wabwinobwino, ndiye kuti kapamba wayandikira kutopa. Panthawi imeneyi, mutha kuyesa kuphatikiza kapangidwe ka insulin ndi zotumphukira za sulfonylurea, koma zotheka, zimathandizanso. Ngati insulini yanu yatha kupangidwa, odwala matenda ashuga amafunika insulin. Osachedwetsa chiyambi chake. Mavuto a shuga amapezeka ngakhale ndi shuga wambiri.
Galvus kapena Metformin
Ku Galvus Mete, zinthu zomwe zikugwira ndizofanana. Zonsezi zimakhudza kuchuluka kwa shuga, koma zimachita zochita zawo mosiyanasiyana. Metformin - makamaka chifukwa cha kuchepa kwa insulin, vildagliptin - kuwonjezeka kwa kaphatikizidwe ka insulin. Mwachilengedwe, momwe multifactorial imathandizira pamavuto. Malinga ndi zotsatira zake, kuwonjezeredwa kwa Galvus ku metformin kumachepetsa hemoglobin ya glycated ndi 0.6% m'miyezi itatu.
Palibe nzeru kuganiza kuti Galvus kapena metformin ndiyabwino. Metformin imatengedwa kumayambiriro kwa matendawa limodzi ndi zakudya ndi masewera, a mankhwalawo, Glucofage woyambirira kapena generic yapamwamba kwambiri ya Siofor imakondedwa. Pomwe sikokwanira, Galvus amawonjezeredwa ku regimen yothandizira kapena metformin yoyipa ya Galvus imasinthidwa.
Njira zotsika mtengo zotsalira ku Galvus
Mapiritsi ndi otsika mtengo kuposa a Galvus, koma omwe amatetezeka komanso othandiza pano palibe. Mutha kuchepetsa kukula kwa matenda a shuga ndi kuphunzitsidwa pafupipafupi, zakudya zamafuta ochepa, komanso metformin yotsika mtengo. Kubwezeredwa kwabwino kwa matenda ashuga, mankhwala enanso okwanira safunika.
Kukonzekera kodziwika bwino kwa sulfonyl urea, monga Galvus, kumapangitsa kaphatikizidwe ka insulin. Izi zikuphatikiza Maninil wamphamvu, koma osakhala wotetezeka, Amaryl ndi Diabeteson MV wamakono. Sangatengedwe ngati fanizo la Galvus, popeza momwe zochita za mankhwalawa zimasiyana kwambiri. Zomwe zimachokera ku sulfonylureas zimayambitsa hypoglycemia, zochulukitsa zikondamoyo, zimathandizira kuwonongeka kwa maselo a beta, chifukwa chake mukazitenga, muyenera kukonzekera kuti mu zaka zochepa mudzafunika insulin. Galvus imalepheretsa kufa kwa maselo a beta, kukulitsa kugwira ntchito kwa kapamba.
Malamulo Ovomerezeka
Mlingo Wovomerezeka wa Vildagliptin:
Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva
Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.
Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Science idatha kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.
Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga amatha kuzipeza February 17 - Kwa ma ruble 147 okha!
>> ONANINSO ZABWINO POPHUNZITSANI CHITSANZO
- 50 mg kumayambiriro kwa makonzedwe, akagwiritsidwa ntchito limodzi ndi kukonzekera kwa sulfonylurea, amatenga piritsi m'mawa,
- 100 mg ya odwala matenda ashuga kwambiri kuphatikizapo insulin. Mankhwalawa amagawidwa pawiri.
Kwa metformin, mulingo woyenera kwambiri ndi 2000 mg, omwe ndi 3000 mg.
Galvus imatha kuledzera pachabe kapena pamimba yonse, Galvus Met - kokha ndi chakudya.
Kuchepetsa chiopsezo cha mavuto
Malinga ndi odwala matenda ashuga, Galvus Met imalekerera pang'ono kuposa metformin yangwiro, koma nthawi zambiri imayambitsa zovuta zam'mimba: kutsegula m'mimba, kusanza, komanso kusamva bwino m'mimba. Kukana chithandizo ndi zizindikiro zotere sikuli koyenera. Kuti muchepetse kuwopsa kwa zovuta, muyenera kupatsa thupi nthawi kuti lizolowere mankhwala. Chithandizo chimayamba ndi mlingo wocheperako, pang'onopang'ono kuwonjezerera kuti ukhale wokwanira.
Chitsanzo cha algorithm pakukulitsa mlingo:
- Tikugula paketi ya Galvus Met ya mlingo wocheperako (50 + 500), sabata loyamba lomwe timatenga piritsi limodzi.
- Ngati palibe vuto la kugaya chakudya, timasinthira ku kachulukidwe kawiri m'mawa ndi madzulo. Simungathe kumwa Galvus Met 50 + 1000 mg, ngakhale mulinso chimodzimodzi.
- Paketi itatha, mugule 50 + 850 mg, imwani mapiritsi awiri.
- Ngati shuga akadali pamwamba pa chizolowezi, kumapeto kwa mapaketi, timasinthira ku Galvus Met 50 + 1000 mg. Simungachulukenso mlingo.
- Ngati malipiro a shuga sakwanira, timawonjezera sulfonylurea kapena insulin.
Odwala onenepa omwe ali ndi matenda ashuga amalangizidwa kuti azimwa mlingo waukulu wa metformin. Pankhaniyi, madzulo, iwo amamwa Glucofage kapena Siofor 1000 kapena 850 mg.
Ngati shuga osala kudya amakwezedwa, ndipo mutatha kudya pafupipafupi m'njira zambiri, chithandizo chimatha kusintha: imwani Galvus kawiri, komanso Glucofage Long - kamodzi pamadzulo pa 2000 mg. Glucofage yowonjezera imagwira ntchito mwachangu usiku wonse, potero kuonetsetsa kuti glycemia imayamba m'mawa. Kuopsa kwa hypoglycemia kulibe.
Kuyenderana ndi mowa
M'malangizo opita kwa Galvus, mowa sunatchulidwe, zomwe zikutanthauza kuti mowa suwononga magwiridwe antchito komanso samawonjezera mavuto. Koma mukamagwiritsa Galvus Meta, uchidakwa ndi kuledzera umaphatikizidwa, chifukwa zimachulukitsa mwayi wa lactic acidosis. Kuphatikiza apo, kumamwa mowa nthawi zonse, ngakhale pang'ono, kumapangitsa kubwezeretsa shuga. Kumwa moledzera kosawerengeka kumawoneka kotetezeka ngati kuchuluka kwa kuledzera kuli kochepa. Pafupifupi, ndi 60 g ya mowa kwa akazi ndi 90 g ya amuna.
Zokhudza kulemera
Galvus Met ilibe phindu lililonse mwachindunji, koma zonse zomwe zimagwira pakapangidwe kazake zimasintha mafuta kagayidwe ndipo zimachepetsa njala. Malinga ndi ndemanga, chifukwa cha metformin, odwala matenda a shuga amatha kutaya mapaundi ochepa. Zotsatira zabwino zimakhala ndi anthu omwe ali ndi matenda ashuga omwe ali ndi kulemera kambiri komanso amanenedwa kuti ali ndi insulin.
Kodi Metformin ndi chiyani?
Maziko a shuga mellitus amtundu wachiwiri ndikuphwanya kuzindikira kwa zolandilira mu ziwalo ndi minyewa yake ku insulin, kapena insulin.
Mapiritsi okhathamira okhala ndi biconvex kumtunda, obiriwira, mapiritsi okhala ndi muyeso wa 500 mg ndi 1000 mg - ndi chiwopsezo, mlingo wa 850 mg - popanda zoopsa.
Tikuwona pasadakhale kuti mankhwala aliwonse omwe amaperekedwa kwa matenda ashuga ali ndi zovuta zingapo zoyipa.
Komanso, zomwe tikufotokozera sizotetezeka, koma tidzalankhula izi pang'ono.
Zimatengera mankhwala a hypoglycemic (kalasi yayikulu), i.e. omwe amatha kupondereza, kuchepetsa magazi.
Izi zimachitika pafupifupi mukangomaliza kukonzekera munali metformin hydrochloride. Izi zimachitika chifukwa zimathandizira kuti maselo azikhala ndi insulin komanso kumwa, kutulutsa kwa glucose kumawonjezeka kwambiri. Zowonadi, mwa odwala angapo, pamodzi ndi izi, pali kuwonjezeka kwa magwiritsidwe a shuga (kwa wina, pafupifupi 50%).
Nthawi zina odwala amadandaula kuti mankhwalawa sawathandiza, ndiye kuti, sagwirizana ndi ntchito yake yayikulu - yotulutsa shuga. Izi zitha kuchitika pazifukwa zingapo. Pansipa ndalemba zifukwa zomwe metformin singathandizire.
- Metformin sinatchulidwepo chizindikiro
- Osakwanira mlingo
- Chithandizo Cha Mankhwala
- Kulephera kudya mukamamwa metformin
- Munthu aliyense
Nthawi zina zimakhala zokwanira kukonza zolakwika ndikuchepetsa shuga sizingakudikirire.
Pa izi ndikufuna kumaliza nkhani yanga. Lembetsani ku zosintha za blog kuti mumve zodalirika komanso zofunikira zokhudzana ndi matenda ashuga komanso zina. Dinani mabatani ochezera. ma network ngati mumakonda nkhani ndikuwona posachedwa!
Ndi chisangalalo ndi chisamaliro, endocrinologist Lebedeva Dilyara Ilgizovna
"Metformin" ndi ofanana - mankhwala a hypoglycemic omwe amadziwika kuti amathandizira odwala matenda ashuga - makamaka amtundu wachiwiri, koma nthawi zina, mankhwalawa amatengedwa ndi mtundu woyamba. Chiyambireni mu 1957, Metformin adakhalabe mankhwala othandizira othandizira matenda a shuga, makamaka ndi zovuta monga kunenepa kwambiri.
Insulin imalimbikitsa kuyika kwamafuta, ndipo Metformin, yotsitsa insulin yomwe ili mthupi, imathandizira kuti ichotse. Ndi chifukwa ichi. Anthu ambiri amagwiritsa ntchito Metformin ngati mapiritsi azakudya.
Njira zoteteza za Metformin
Kodi chimapangitsa kuti chithandizire ndi chiyani?
- Mankhwala amasintha insulin,
- Amathandizira kuwongolera glycemic,
- Fibrinolysis ikupita patsogolo,
- Microcirculation mu zotumphukira zimakhala zimayambitsa,
- Endothelial kukanika kumachepa
- Potengera maziko a metformin, hyperglycemia imachepa,
- Mapangidwe a kumapeto kwa glycation kumapeto kumachepetsedwa,
- Kuchulukana kwa magazi kumaundana
- Kupanikizika kwa Oxidative sikutenga mbali,
- Zothandiza pa atherogenesis ndi dyslipidemia.
Mankhwalawa amachepetsa chiopsezo cha zochitika za mtima ndi matenda ashuga omwe ali ndi mtundu wachiwiri wa matenda, ndipo zotsatira za kukumbukira kwa metabolic zimakuthandizani kuti musunge zotsatira kwanthawi yayitali.
Chithandizo ndi Metformin ndi zotumphukira zake zimachepetsa kwambiri glycemia.
Poyerekeza ndi ma analogi ndi mankhwala ena osokoneza bongo, Metformin imakhala ndi gawo losafuna kulemera ndipo imathandizanso kuchepetsa.
Metformin ya antidiabetesic ili ndi katundu wotsitsa shuga, zomwe zikutanthauza kuti sizingalimbikitse kupanga kwa insulin ndi insulin ndikuchulukitsa ziphuphu, zomwe zimagwira kale ntchito moyenera.
Contraindication ndi zomwe zingavulaze
Pamodzi ndi zabwino pamwambapa za metformin, mwayi wovulaza thupi lathu kumwa mankhwalawa siuphatikizidwa.
Choopsa chachikulu cha mankhwalawa chagona pakuwonera mayendedwe oyamba a anthu odwala matenda ashuga, pomwe amakakamizidwa kuti azilamulira kuchuluka kwa glycemia poletsa zakudya zamagulu owonjezera a calcium komanso kuwonjezera zochitika zolimbitsa thupi.
Popanda chakudya, magwiridwe antchito am'thupi onse amunthu, makamaka ubongo, womwe umagwiritsidwa ntchito pongodya mphamvu zokhazokha - shuga, ndizosatheka. Ngati kudya shuga kwachepetsedwa kwambiri, ndiye kuti mulingo wake m'magazi umatsika kwambiri, womwe umayambitsa kuphwanya.
Koma mthupi mwathu muli zotsekera zosunga zolakwika zotere, zomwe zitha kulipirira kuchepa kwambiri kwachinthu. Chimodzi mwazomwe zimathandizira kuti chiwopsezo cha hypoglycemia ndi hepatic gluconeogenesis, pomwe glucagon imayamba kubwezeretsanso kupanga shuga m'magazi a chiwindi omwe amasungidwa kale, koma mukamamwa mankhwalawa amachepetsa!
Lactic acidosis (kapena lactic acidosis, lactic acid chikomokere) imakula mwachangu ndi zovuta zomwe zilipo ndi impso (ndi matenda a shuga a m'mbuyomu, omwe amayamba kukhala olakwika aimpso), popeza metformin hydrochloride imadziunjikira mu tiziwalo tating'onoting'ono, minofu, chiwindi, ndi minyewa ya impso. ndipo wongoperekedwa ndi impso.
Ntchito yawo ikasokonekera, 90% ya mankhwalawa amakhalabe osasintha mthupi la munthu. Koma ndi zonsezi, zovuta zowopsa mu shuga - ketoacidosis, monga lamulo, sizimakula.
Chifukwa chake, ndizowopsa kumwa mankhwala okhala ndi metformin pakagwera vuto la impso kapena vuto lililonse ndi impso, koma akatswiri ambiri am'mawu amodzi amalemberatu, ponena kuti kuchepa kwa glycemia ndikulimbana ndi insulin ndikofunikira, chifukwa cha kuchuluka kwa shuga m'magazi, zovuta zingapo zimayambika, zomwe zimachitika. zimapangitsa kuchuluka kwa anthu odwala matenda ashuga.
Pazochita zapadziko lonse lapansi, mankhwala okhala ndi metformin amalembedwa akangopezeka ndi matenda ndipo amatha kutalikitsa moyo wa odwala matenda ashuga. Ku Russia, monga lamulo, nthawi zambiri limakhazikitsidwa kale pamlingo wapamwamba wa matendawa, pamene metformin imakhala chifukwa china chowonjezera cha kuwonongeka kwa chikhalidwe cha odwala kuphatikiza kuwonjezeka kwa zovuta za matenda osokoneza bongo panthawi yomwe kuyamwa kwakanthawi (m'malingaliro ang'onoang'ono) kumatha kusintha thanzi ndikachedwa chosalephera.
Ndi mtundu wofatsa wa shuga, kukana kwa zotengera zomwe zimadalira insulin, motero, chithandizo chachikulu ndikuchepetsa kukana kwa insulin. Zomwe ngwazi yathu imatha kuthana nayo mosavuta ngakhale pazingwe zazing'ono, zomwe sizitha kuvulaza thupi.
Koma, mwatsoka, ndalama zosungira insulin mu mtundu 2 wa shuga zimatha (i., Insulin sizikupangidwanso mopanda muyeso wofunikira), ndiye kuti madokotala amakakamizidwa kuti awonjezere zolimbikitsa za insulin kudzichiritsa - awa ndi masanfanilamides.
Pambuyo pake, ngati akutsimikizira kuti ndi osathandiza, ndiye kuti kukonzekera kwa insulin nthawi zambiri kumaphatikizidwa ndi mankhwalawa, nthawi zambiri kuphatikiza ndi mankhwala omwe amachititsa chidwi cha insulin yodalira insulin (iyi ndi chikhalidwe chathu chachikulu ndi inu).
Zotsatira zina zoyipa ndizophatikiza:
- mavuto am'mimba (nseru, kusanza, kutulutsa, mpweya, kutsegula m'mimba)
- kukomoka
- kuphwanya kukoma (mwachitsanzo, kukoma kwazitsulo mu chakudya chomwe mumadya)
- kusowa kwa Vitamini B12 (chifukwa chake, kuchuluka kowonjezera kumalimbikitsidwa
mavitamini a shuga
Zochuluka motani
Mankhwala amapezeka monga mapiritsi. Mapiritsi amaikidwa m'matumba a blister opangidwa ndi polyvinyl chloride ndi zojambulazo za aluminium. Paketi iliyonse ili ndi mapiritsi 10.
Ma paketi asanu ndi amodzi amaikidwa pabokosi lamakatoni, momwe mulinso malangizo ogwiritsira ntchito. Makatoni amakhadi a mankhwalawo ali ndi mapiritsi 60.
Sungani mankhwalawo pamalo otetezedwa ndi dzuwa mwachindunji pa kutentha osaposa 25 digiri Celsius. Mankhwala ayenera kusungidwa kuti ana asawapeze.
Moyo wa alumali wa chinthu chachipatala ndi zaka zitatu. Mankhwala amagulitsidwa ku pharmacies ndi mankhwala.
Ndemanga zambiri zomwe anakumana nazo omwe amagwiritsa ntchito mankhwalawa ndi zabwino. Maonekedwe a ndemanga yoyipa imakonda kuyenderana ndi kuphwanya malangizo ogwiritsira ntchito mankhwalawa kapena ngati mukuphwanya malangizowo kuchokera kwa adokotala. Nthawi zambiri pamakhala kuunikiridwa kwa odwala, zomwe zikuwonetsa kuti kugwiritsa ntchito mankhwalawa kumachepetsa kwambiri thupi.
Wopanga wamkulu wa mankhwalawa ku Russian Federation ndi Ozone LLC.
Mtengo wa mankhwala m'gawo la Russian Federation zimatengera ma network a mafakitole ndi dera lomwe mankhwalawo amagulitsidwa. Mtengo wapakati wa mankhwala ku Russian Federation umachokera ku 105 mpaka 125 ma ruble pa paketi iliyonse.
Ma fanizo odziwika kwambiri a Metformin 500 mu Russian Federation ndi awa:
- ,
- Glycon
- Glyminfor,
- Glyformin
- Chikwanje,
- Glucophage Long,
- Methadiene
- Metospanin
- Metfogamma 500,
- Metformin
- Metformin Richter,
- Metformin Teva,
- Metformin hydrochloride,
- Nova Met
- NovoFormin,
- Siofor 500,
- Sofamet
- Fomu,
- Fomu.
Zofanizira za Metformin ndizofanana zonse mu kapangidwe kake ndi kagawo.
Chiyerekezo chachikulu cha Metformin chomwe chilipo, chimalola, ngati kuli kofunikira, dokotala yemwe amapezeka kuti asankhe mosavuta mankhwalawo ndikusintha Metformin ndi chipangizo china chachipatala. Za momwe Metformin imagwirira ntchito m'matenda a shuga, katswiri adzakuwuzani mu kanema munkhaniyi.
Mtengo wa mankhwalawa umachokera ku ruble 100 mpaka 250, kutengera zomwe zili pompopompo.
Msika wama pharmacological umapereka mapiritsi ambiri ndi mankhwala omwe ali ndi chidwi.
Ngakhale mawonekedwe osiyanasiyana othandizira, mapiritsi siokwera mtengo kwambiri Mwachitsanzo, mtengo wake ku Russia umachokera ku 90 mpaka 260 rubles.
Mtengo wa Metformin kuchokera kumakampani ena akunja opanga mankhwala samasiyana kwambiri.
Mtengo wa Metformin kuchokera kwa opanga osiyanasiyana akunja ndi:
- Slovakia - kuchokera pa ma ruble 130 mpaka 210.
- Hungary - kuyambira 165 mpaka 260 rubles.
- Poland - kuchokera 75 mpaka 320 ma ruble.
Zokonzekera zomwe zimakhala ndi metformin hydrochloride nthawi zambiri zimapezeka kwa gulu lapakati. Mutha kusunga ndalama pogula mapiritsi a shuga pa intaneti. Mtengo wa Metformin umatengera mlingo:
- 500 mg (mapiritsi 60) - kuchokera ku 90 mpaka 250 ma ruble,
- 850 mg (mapiritsi 60) - kuchokera 142 mpaka 248 rubles,
- 1000 mg (mapiritsi 60) - kuchokera 188 mpaka 305 rubles.
Monga mukuwonera, mtengo wa hypoglycemic wothandizira Metformin siwokwera kwambiri, womwe ndi kuphatikiza kwakukulu.
Ndemanga za wodwala zamankhwala zimakhala zabwino. Metformin imachepetsa shuga m'magazi ndipo simatsogolera ku hypoglycemia. Madokotala amavomerezanso kugwiritsa ntchito mankhwala othandizira odwala matenda ashuga. Kugwiritsa ntchito Metformin kosalekeza popewa matenda amtima kulipira.
Anthu ena omwe alibe matenda ashuga amatenga mankhwala kuti achepetse kunenepa. Akatswiri salimbikitsa kugwiritsa ntchito mankhwalawa kuti muchepetse kunenepa kwa anthu athanzi.
Mtengo wamba wa METFORMIN m'masitolo ogulitsa mankhwala (Moscow) ndi ma ruble 110.
Mtengo wapakati wa mapiritsi a Metformin m'masitolo ogulitsa mankhwala ku Moscow umasiyana ndi ma ruble 117-123.
Glucophage (Metformin) yochepetsa thupi. Pomwe sizingatengedwe mulimonse
Akatswiri amavomereza chida ichi pochiza matenda osiyanasiyana.
Bobkov E.V., dokotala wamkulu, wazaka 45, Ufa: "Mankhwala okhazikika omwe amagwiritsidwa ntchito pochiza matenda a shuga a 2."
Danilov S.P., dokotala wamkulu, wazaka 34, Kazan: “Kwa zaka zambiri, kwawonetsa kuyeserera kwake polimbana ndi kunenepa kwambiri. Zimathandizira kwakanthawi kochepa kukwaniritsa zabwino. "
Dmitry, wazaka 43, Vladivostok: “Ndili ndi matenda a shuga. Ndakhala ndikumwa mankhwalawa limodzi ndi jakisoni wa insulin kwa pafupifupi chaka. Amachepetsa magazi. ”
Vladimir, wazaka 39, ku Ekaterinburg: "Kwa nthawi yayitali ndinatenga Glibenclamide, koma pambuyo pake Metformin adasankhidwa. Amatengedwa bwino, ndipo shuga m'magazi amayambiranso kukhala bwino. ”
Svetlana, wazaka 37, Rostov-on-Don: “Ndidagula mankhwalawa pamalangizo a katswiri wazakudya. Sindinasangalale nazo. ”
Valeria, wazaka 33, Orenburg: “Kuyambira ndili mwana, ndinayamba kunenepa kwambiri. Dokotala wopezekapo adalangiza Metformin. Patatha mwezi umodzi, ndinasiya kuzitenga, chifukwa kuzunzidwa ndi chizungulire ndi mseru. "
Metformin imapereka kuthamanga kwa kuchepetsa shuga mu pafupifupi odwala onse. Kubwezerani kwakanthawi kwamankhwala kumachitika pafupipafupi.
Kuti ndiwathetse, ndikulimbikitsa kusinthira pamapiritsi otulutsa pang'onopang'ono, kumwa iwo asanagone. Tayi kapena madzi okhala ndi mandimu amathandiza bwino kuchokera ku matenda am'mawa komanso kukoma mkamwa.
Nthawi zambiri ndimafunsa kwa milungu iwiri, pomwe nthawi zambiri zizindikiro zimatha. Nthawi zambiri ndimakhala osalolera, nthawi zonse ndimataya.
Ndakhala ndikutsogoza anthu odwala matenda ashuga kwa zaka zingapo ndipo nthawi zonse ndimapereka mankhwala a Metformin m'gulu lachiwonetsero cha matenda a 2. Poyerekeza odwala achinyamata olemera kwambiri amakhala ndi zotsatira zabwino.
Ndikukumbukira nthawi ina, mayi wina adakwanitsidwa ndi makilogalamu 150 ndikutulutsa kunenepa kwambiri pamimba. Adadandaula chifukwa cha kulephera kuchepetsa thupi, ngakhale kuti zopatsa mphamvu za tsiku ndi tsiku, malinga ndi iye, sizidafikire 800 kcal nthawi zonse.
Kuyesedwa kunawonetsa kuloleza kwa glucose. Ndidalemba ma multivitamini okha komanso Metformin, adavomereza kuti wodwalayo azitha kudya calorie mpaka 1,500 ndikuyamba kuyendera dziwe katatu sabata.
Mwambiri, "njirazi zayamba" mwezi umodzi. Tsopano ndi 90 kg, sangaime pamenepo, matenda a prediabetes amachotsedwa.
Sindimaganiza kuti ndi mankhwala okha, koma Metformin ndiye adalimbikitsa.
Popereka mankhwala a Metformin, nthawi zonse ndimanenanso kuti ndibwino kumwa mankhwalawa. Zotsatira zakugwiritsa ntchito mitundu yama Indian ndi China nthawi zonse zimakhala zoyipa. Mankhwala a ku Europe ndi kwanyumba ndi njira yabwino ngati simungathe kupeza Glucophage.
- Kodi metformin ingagwiritsidwe ntchito kupewa matenda ashuga?
- Mtundu wachiwiri wa mankhwala a shuga
- Momwe mungalandire metformin mu mtundu 2 wa shuga
- Zowonongeka ndi matenda a shuga
Zotsatira za mankhwala
Chifukwa cha vildagliptin, zovuta zoyipa za dipeptidyl peptidase-4 zimachepetsedwa, ndipo kupanga kwa GLP-1 ndi HIP, m'malo mwake, kumalimbikitsidwa. Mlingo wa zinthuzi m'magazi utakwera, vildagliptin imasintha chiwopsezo cha maselo a beta ku glucose wopangidwa, potero, imathandizira kupanga shuga yotsitsa shuga. Tizikumbukira kuti phindu lothandizira magwiridwe antchito a maselo a beta zimatengera mulingo wowonongera. Chifukwa chake, mwa anthu omwe ali ndi shuga omwe ali ndi shuga, vildagliptin sichikhudzanso kupanga kwa insulini, komanso, kupanga shuga.
Gawo lothandizirali limachulukitsa kuchuluka kwa GLP-1 ndipo nthawi yomweyo limakulitsa chidwi cha maselo a alpha a pulogalamu ya islet. Zotsatira zake, kupanga kwa glucagon kumawonjezeka. Kutsika kwa kuchuluka kwake pakudya kumadzetsa chidwi cha zotumphukira zama cell kuzinthu zama cell zomwe zimachepetsa shuga.
Pakukwera msanga kwamisempha, glucagon ndi kuchuluka kwa insulin, zomwe zimadalira mwachindunji pakupanga kwa GLP-1 ndi HIP, njira yopanga shuga m'chiwindi imachepetsa onse pakudya komanso pambuyo pake, zomwe zimayambitsa kuchepa kwa kuchuluka kwa shuga m'magazi. Tisaiwale kuti kungokhala kokhazikika kwa GLP-1 kungachedwetse kutsuka kwa m'mimba, ngakhale muzochita zamankhwala sikunadzetse chitukuko.
Kugwiritsa ntchito kwazinthu ziwiri - metformin ndi vildagliptin, kumawongolera glycemia wodwala matenda ashuga kwa maola 24.
Malangizo ogwiritsira ntchito mapiritsi
Kudya sikukhudzana ndikugwiritsa ntchito mankhwalawa Galvus kapena Galvus Met.
Musanagwiritse ntchito mankhwalawa, ndikofunikira kufunafuna thandizo la katswiri yemwe angadziwe payekha.
Malangizo omwe ali pompopompo a Galvet 50 mg amawonetsa mlingo womwe ungasinthidwe ndi dokotala:
- Ndi monotherapy kapena kuphatikiza ndi insulin, thiazolidinedione, metformin - 50-100 mg.
- Omwe ali ndi mtundu wotsogola kwambiri amatenga 100 mg pa tsiku.
- Kulandila kwa vildagliptin, zochokera ku sulfonylurea ndi metformin - 100 mg patsiku.
- Kugwiritsira ntchito kozama kwa sulfonylurea ndi Galiv zimachokera ku mlingo wa 50 mg patsiku.
- Ngati munthu wodwala matenda ashuga ali ndi vuto lochepa kwambiri komanso laimpso, tsiku lililonse ndi 50 mg.
Choikidwacho chili ndi chidziwitso kuti mlingo wa 50 mg uyenera kutengedwa nthawi imodzi m'mawa, ndipo 100 mg igawidwe magawo awiri - m'mawa ndi madzulo.
Mlingo wa mankhwala a Galvus Met amatsimikizidwanso ndi dokotala, poganizira kuchuluka kwa shuga ndi kulolerana kwa zigawo za mankhwala kwa wodwala. Bukuli likuwonetsa milingo yotsatira:
- osagwiritsa ntchito vildagliptin, tikulimbikitsidwa kuti mutenge 50/500 mg kawiri patsiku,
- Ngati kugwiritsa ntchito metformin sikothandiza, tengani 50/500 mg, 50/8 mg kapena 50/1000 mg kawiri patsiku, kutengera metformin yomwe idagwiritsidwa ntchito kale,
- kuphatikiza kosakwanira kwa vildagliptin ndi metformin, 50/500 mg, 50/8 mg kapena 50/1000 mg kawiri pa tsiku kumagwiritsidwa ntchito, kutengera magawo omwe amagwiritsidwa ntchito,
- Pa mankhwala oyamba ndi mankhwalawa chifukwa cha kusakwanira kwa zakudya komanso masewera olimbitsa thupi, imwani 50/500 mg kamodzi patsiku,
- kuphatikiza ndi insulin mankhwala ndi zotumphukira za sulfonylurea, mlingo wa vildagliptin ndi 50 mg kawiri patsiku, ndipo metformin imakhala yofanana ndi monotherapy.
Kugwiritsa ntchito mankhwalawa ndizoletsedwa kwa odwala matenda ashuga omwe amayamba chifukwa cha kulephera kwa impso ndi zina zomwe zimayambitsa ziwalo. Kuphatikiza apo, chisamaliro chapadera chimaperekedwa kwa odwala omwe ali ndi zaka zapamwamba (zopitilira 65), chifukwa nthawi zambiri amakhala ndi kuchepa kwa impso.
Dokotala amatha kuwonjezera kuchuluka kwa mankhwalawa, komabe, ndizoletsedwa kuchitira nokha chithandizo, izi zingayambitse zotsatira zoyipa komanso zosasinthika.
Mtengo, malingaliro ndi masinthidwe
Wopanga mankhwalawa ndi kampani yaku Swiss pharmacological ya Novartis, yomwe imapanga mankhwala okhala ndi vildagliptin kapena kuphatikiza kwa vildagliptin ndi metformin.
Mankhwala osokoneza bongo amatha kuyitanidwa pa intaneti kapena ingopita ku pharmacy yapafupi. Mtengo wa mankhwala umatengera mawonekedwe ake. Mtengo wake ndi motere:
- Galvus 50 mg (mapiritsi 28) - ma ruble 765.
- Galvus Met 50/500 mg (mapiritsi 30) - 1298 ma ruble.
- Galvus Met 50/850 mg (mapiritsi 30) - 1380 ma ruble.
- Galvus Met 50/1000 mg (mapiritsi 30) - 1398 ma ruble.
Monga mukuwonera, mankhwalawa siotsika mtengo kwenikweni. Sikuti aliyense azitha kulandira mankhwala okhazikika ndi mankhwalawa, choncho pakufunika kusankha mankhwalawa, omwe tikambirane pambuyo pake.
Ponena za lingaliro lamankhwala Galvus, ali ndi chiyembekezo. Ndemanga ya ambiri omwe amamwa mankhwalawa akuwonetsa kuti pambuyo pa miyezi 1-2 atamwa Galvus, zizindikiro za glucose zimabwezeretsa. Kuphatikiza apo, odwala matenda ashuga monga momwe mumagwiritsira ntchito mankhwalawa mutha kudya zakudya zoletsedwa m'mbuyomu. Galvus Met, chifukwa cha metformin yake, imathandizira kutaya mapaundi owonjezera a 3-4 kwa odwala omwe ali ndi kunenepa kwambiri. Komabe, mankhwalawo ali ndi njira imodzi yayikulu - ndi mtengo wake wokwera.
Ngati wodwala akuletsedwa kugwiritsa ntchito Galvus chifukwa cha contraindication kapena chifukwa cha mbali, dokotala amamulembera mankhwala ena. Izi zimatha kukhala zofananira, ndiye kuti, zinthu zomwe zimakhala ndi zinthu zomwezo, kusiyana kumangokhala pazowonjezera. Galvus Met ndiye malo amodzi ofanana ndi Galvus; awa ndi magawo awiri okhala ndi vildagliptin.
Komabe, mankhwalawa ali ndi zithandizo zambiri zofanana zofanizira, zomwe zidzafotokozedwanso pambuyo pake.
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