Mikardis® (40 mg) Telmisartan

Mankhwalawa ndi mapiritsi oyera okhala ndi mawonekedwe a 51H olembedwa m'mphepete mwake ndi logo yamakampani mbali inayo.

Mapiritsi 7 oterewa ali ndi mulingo wa 40 mg mu chithuza; 2 kapena 4 matuza oterowo mu katoni. Pafupifupi mapiritsi 7 oterewa omwe ali ndi mulingo wa 80 mg wa chithuza, matuza awiri, 4 kapena 8 m'bokosi lamatoni

Pharmacodynamics ndi pharmacokinetics

Mankhwala

Telmisartan - kusankha receptor blocker angiotensin II. Ali ndi kutentha kwakukulu AT1 cholandilira subtype angiotensin II. Kupikisana ndi angiotensin II mu ma receptor osakhala ndi zofanana. Kumangiriza ndikupitiliza.

Siziwonetsa kutenthedwa kwa ma subtypes ena a receptors. Imachepetsa zomwe zili aldosterone m'magazi, sikumachepetsa plasma renin ndi njira za ion m'maselo.

Yambani Hypotensive zotsatira Amawonedwa pa maola atatu oyamba atatha kukhazikitsa telmisartan. Mchitidwewu ukupitilira kwa tsiku limodzi kapena kupitilira apo. Mphamvu yotchulidwa imayamba mwezi umodzi wokhazikika.

Mwa anthu okhala ndi ochepa matenda oopsatelmisartan amachepetsa kuthamanga kwa magazi kwa systolic ndi diastolic, koma sasintha kuchuluka kwa mtima.

Sizimayambitsa kusiya achiwerewere.

Pharmacokinetics

Ikamamwa pakamwa, imatengedwa mwachangu kuchokera m'matumbo. Bioavailability ikuyandikira 50%. Pambuyo maola atatu, ndende ya plasma imakhala yokwanira. 99.5% ya chinthu chomwe chimagwira ndimapuloteni amwazi. Kupangidwa poyankha ndi glucuronic acid. Ma metabolites a mankhwalawa sagwira ntchito. Kuthetsa theka-moyo woposa maola 20. Amachotseredwa m'mimba, kutulutsa kwamkodzo kumakhala kochepera 2%.

Contraindication

Mapiritsi a Micardis amatsutsana mwa anthu omwe ali nawo chifuwa pazigawo za mankhwala, zolemetsa matendachiwindi kapenaimpso,fructose tsankho, pa mimba ndi nyere, ana osakwana zaka 18.

Zotsatira zoyipa

• Kuchokera ku dongosolo lamanjenje lalikulu: kukhumudwachizungulire mutukutopa, kuda nkhawa, kusowa tulo, kukokana.
• Kuchokera kupuma dongosolo: matenda a chapamwamba kupuma thirakiti (sinusitis, pharyngitis, bronchitis), chifuwa.
• Kuchokera kwamuzungulire: kutchulidwa kuchepa kwa mavuto, tachycardia, bradycardiakupweteka pachifuwa.
• Kuchokera kugaya chakudya: nseru, kutsegula m'mimba, dyspepsiakuchuluka kuchuluka kwa chiwindi michere.
• Kuchokera ku minculoskeletal system: myalgiakupweteka kumbuyo arthralgia.
• Kuchokera ku genitourinary system: edema, matenda a genitourinary system, hypercreatininemia.
• Hypersensitivity Reaction: Khungu Zotupa, angioedema, urticaria.
• Zizindikiro zasayansi: kuchepa magazi, Hyperkalemia.
• Zina: erythemakuyabwa dyspnea.

Mikardis, malangizo ogwiritsira ntchito

Malinga ndi malangizo ogwiritsira ntchito Mikardis, mankhwalawa amatengedwa pakamwa. Chalangizidwa kwa akulu mlingo 40 mg kamodzi patsiku. Mu odwala angapo, achire zotsatira zimawonedwa kale akamamwa mankhwala20 mg patsiku. Ngati kuchepa kwa kukakamizidwa pamlingo wofunidwa sikunawonedwe, ndiye kuti mlingowo ungathe kuwonjezeka mpaka 80 mg patsiku.

Kuchuluka kwa mankhwalawa kumatheka patadutsa masabata asanu atayamba chithandizo.

Odwala ovuta mitundu ochepa matenda oopsa kugwiritsa ntchito 160 mgmankhwala patsiku.

Kuchita

Telmisartan yambitsa Hypotensive zotsatira njira zina zochepetsera kupanikizika.

Mukamagwiritsa ntchito limodzi telmisartan ndi digoxin Nthawi ndi nthawi kuganizira za ndende ndikofunikira digoxin m'magazi, chifukwa amatha kuchuluka.

Mukamamwa mankhwala limodzi lifiyamu ndi ACE zoletsa kuwonjezeka kwakanthawi kawonedwe lifiyamum'magazi, owonetsedwa ndi zoyipa.

Chithandizo mankhwala osapweteka a antiidal pamodzi ndi Mikardis mu odwala omwe alibe madzi am'mimba amatha kutsogolera kukula kwa impso.

Malangizo apadera

Chifukwa odwala osowa madzi m'thupi (kuletsa mchere, chithandizo okodzetsa, kutsegula m'mimba, kusanza) kuchepa kwa mlingo wa Mikardis ndikofunikira.

Mosamala, sankhani anthu omwe stenosismwa onse mitsempha ya impso, mitral valve stenosiskapena aortic hypertrophic cardiomyopathy zotupa, aimpso kwambiri, kwa chiwindi kapena mtima kulephera, matenda am'mimba.

Ndi zoletsedwa kugwiritsa ntchito liti chachikulu aldosteronismndi fructose tsankho.

Ndi mimba yomwe mwakonza, muyenera kupeza kaye malo a Mikardis ndi enanso antihypertensive mankhwala.

Gwiritsani ntchito mosamala mukamayendetsa magalimoto.

Pogwiritsa ntchito mankhwala osokoneza bongo lifiyamu kuyang'anira zinthu za lithiamu m'magazi akuwonetsedwa, chifukwa kuwonjezeka kwakanthawi pamlingo wake ndizotheka.

Mlingo

Mapiritsi 40 mg, 80 mg

Piritsi limodzi lili

ntchito yogwira - telmisartan 40 kapena 80 mg, motero,

zokopa: sodium hydroxide, povidone K 25, meglumine, sorbitol P6, magnesium stearate.

40 mg mapiritsi - mapiritsi okhala ndi mawonekedwe, oyera kapena pafupifupi oyera, okhala ndi chizindikiro cha 51N mbali imodzi ndi logo ya kampaniyo mbali inayo, ndi biconvex kumtunda, makulidwe a 3.6 - 4.2 mm.

Mapiritsi a 80 mg - mapiritsi okhala ndi mawonekedwe, oyera kapena pafupifupi oyera, okhala ndi chizindikiro cha 52N mbali imodzi ndi logo ya kampani inayo, yokhala ndi biconvex kumtunda, 4.4 - 5.0 mm.

Mankhwala

Pharmacokinetics

Telmisartan imatengedwa mwachangu, kuchuluka kwake komwe kumamwa kumasiyana. The bioavailability wa telmisartan pafupifupi 50%.

Mukamamwa telmisartan nthawi yomweyo ndi chakudya, kuchepa kwa AUC (dera lozunguliridwa ndi nthawi yoponderezedwa) kumachokera ku 6% (pa 40 mg) mpaka 19% (pa mlingo wa 160 mg). Pakadutsa maola atatu atatha kumwa, kuchuluka kwa madzi am'magazi kumatha, ngakhale chakudya. Kutsika pang'ono kwa AUC sikupangitsa kuti mankhwalawa athe kuchepa.

Pali kusiyana pamaganizidwe a plasma mwa amuna ndi akazi. Cmax (ndende yozungulirapo) ndi AUC anali okwera pafupifupi katatu ndi kawiri mwa azimayi poyerekeza ndi abambo popanda phindu lalikulu.

Kuyankhulana ndi mapuloteni a plasma oposa 99.5%, makamaka ndi albumin ndi alpha-1 glycoprotein. Kuchuluka kwa magawo ndi 500 malita.

Telmisartan imapangidwa poyanjanitsa zinthu zoyambira ndi glucuronide. Palibe pharmacological ntchito ya conjugate yomwe idapezeka.

Telmisartan ali ndi chikhalidwe chodziwika bwino cha pharmacokinetics ndikuchotsa kupatula kwa theka-moyo> maola 20. Cmax ndi - mochepera - AUC ichulukane mosasamala ndi mlingo. Palibe kondwerero yofunika kwambiri ya telmisartan yomwe yapezeka.

Pambuyo pakumwa pakamwa, telmisartan imangotsala kwathunthu kudzera m'matumbo osasinthika. Kutulutsa kwathunthu kwamkodzo kumachepera 2% ya mlingo. Chilolezo chonse cha plasma ndi chachikulu (pafupifupi 900 ml / min) poyerekeza ndi magazi a hepatic (pafupifupi 1500 ml / min).

Odwala okalamba

Ma pharmacokinetics a telmisartan mwa odwala okalamba sasintha.

Odwala omwe ali ndi vuto la impso

Odwala omwe ali ndi vuto la impso akukumana ndi hemodialysis, kutsika kwa plasma kumawonedwa. Odwala omwe amalephera kupweteka kwa impso, telmisartan imagwirizanitsidwa kwambiri ndi mapuloteni a plasma ndipo samachotsa pakhungu. Ndi kulephera kwa aimpso, theka la moyo silisintha.

Odwala omwe ali ndi vuto la chiwindi

Odwala ndi hepatic kusowa, kutsimikizika bioavailability wa telmisartan ukuwonjezeka mpaka 100%. Hafu ya moyo wa chiwindi kulephera sasintha.

The pharmacokinetics ya jakisoni awiri a telmisartan adayesedwa mwa odwala omwe ali ndi matenda oopsa (n = 57) azaka 6 mpaka 18 atatenga telmisartan pa Mlingo wa 1 mg / kg kapena 2 mg / kg pakanthawi kwamankhwala anayi. Zotsatira za kafukufukuyu zatsimikiza kuti pharmacokinetics ya telmisartan mwa ana osaposa zaka 12 amagwirizana ndi omwe ali ndi akulu, makamaka, chikhalidwe chosagwirizana ndi Cmax chatsimikiziridwa.

Mankhwala

MIKARDIS ndi wogwira mtima komanso wosankha (wosankha) wa angiotensin II receptor antagonist (mtundu wa AT1) wowongolera pakamwa. Telmisartan yokhala ndi ogwirizana kwambiri imasamutsa angiotensin II kuchokera m'malo ake omangiramo malo a AS1 subtype receptors, omwe ali ndi udindo wothandizira angiotensin II. Telmisartan ilibe agonist mphamvu pa AT1 receptor. Telmisartan mosamala imamangirira ku receptors a AT1. Kulumikizana ndikupitiliza. Telmisartan siziwonetsa kuyanjana kwa receptor ena, kuphatikizapo AT2 receptor ndi ena, sanaphunzire kwambiri AT receptors.

Kufunika kwa magwiridwe antchito izi, komanso momwe zimakhalira ndikulimbikitsa kwakukulu ndi angiotensin II, kugwiritsidwa ntchito kwa zomwe zimawonjezeka poika telmisartan, sikunaphunzire.

Telmisartan imachepetsa plasma aldosterone, sichiletsa renin mu plasma ya anthu ndi njira za ion.

Telmisartan sichimaletsa enzyme yotembenuza-angiotensin (kinase II), yomwe imawononga bradykinin. Chifukwa chake, palibe kukonzekera kwa mavuto omwe amabwera chifukwa cha bradykinin.

Mwa anthu, mlingo wa 80 mg wa telmisartan pafupifupi umalepheretsa kuthamanga kwa magazi (BP) chifukwa cha angiotensin II. Mphamvu ya inhibitory imasungidwa kwa maola opitilira 24 ndipo imatsimikiziridwabe pambuyo pa maola 48.

Chithandizo cha ochepa matenda oopsa

Mutatenga mlingo woyamba wa telmisartan, kuthamanga kwa magazi kumachepa pambuyo pa maola atatu. Kutsika kwakukulu kwa kuthamanga kwa magazi kumatheka pang'onopang'ono masabata 4 pambuyo poyambira chithandizo ndikusungidwa kwanthawi yayitali.

Mphamvu ya antihypertensive imatha kwa maola 24 mutatha kumwa mankhwalawa, kuphatikiza maola 4 musanamwe mlingo wotsatira, womwe umatsimikiziridwa ndi kuchuluka kwa kuthamanga kwa magazi, komanso kukhazikika (kwapamwamba 80%) pazakuchepera komanso kuzama kwa mankhwalawa mutatenga 40 ndi 80 mg ya MIKARDIS pakuyesedwa kwachipatala. .

Odwala omwe ali ndi matenda oopsa, MIKARDIS imachepetsa kuthamanga kwa magazi kwa systolic ndi diastolic popanda kusintha kugunda kwa mtima.

Mphamvu ya antihypertensive ya telmisartan ikufanizidwa ndi oimira magulu ena a antihypertensive mankhwala, monga: amlodipine, atenolol, enalapril, hydrochlorothiazide, losartan, lisinopril, ramipril ndi valsartan.

Pankhani yakuchotsedwa kwadzidzidzi kwa MIKARDIS, kuthamanga kwa magazi pang'onopang'ono kumabwereranso kuzikhalidwe musanalandire chithandizo kwa masiku angapo popanda zizindikiro za kuyambiranso kwamankhwala oopsa (palibe "rebound").

Kafukufuku wachipatala awonetsa kuti telmisartan imagwirizanitsidwa ndi kuchepa kwakukulu kwa kuchuluka kwamanzere kwamitsempha yamanzere yamanzere yamanzere yamitsempha yamagazi kwa odwala omwe ali ndi matenda oopsa komanso osagwirizana ndi hypertrophy yamanzere.

Odwala omwe ali ndi matenda oopsa komanso matenda ashuga nephropathy omwe amathandizidwa ndi MIKARDIS amawonetsa kuchepa kwakukulu kwa proteinuria (kuphatikizapo microalbuminuria ndi macroalbuminuria).

M'mayesero azachipatala apadziko lonse lapansi, zinawonetsedwa kuti panali owerengeka ochepa odwala omwe adwala telmisartan kuposa odwala omwe amalandila angiotensin-converting enzyme inhibitors (ACE inhibitors).

Kupewa matenda a mtima komanso kufa

Odwala azaka zapakati pa 55 ndi akulu omwe ali ndi mbiri yodwala matenda a mtima, matenda opha ziwalo, matenda amitsempha kapena matenda a shuga. kulephera kwa mtima ndi kuchepetsa kufa kwa matenda amtima.

Mphamvu ya antihypertensive ya telmisartan idayesedwa mwa odwala omwe ali ndi zaka 6 mpaka 18 (n = 76) atatenga telmisartan pa mlingo wa 1 mg / kg (ankachitira n = 30) kapena 2 mg / kg (ankachitira n = 31) pakanthawi yamankhwala anayi .

Kuthamanga kwa magazi kwa systolic (SBP) kutsika kuchokera pa mtengo woyambira ndi 8.5 mm Hg ndi 3.6 mm Hg. m'magulu a telmisartan, 2 mg / kg ndi 1 mg / kg, motsatana. Kuthamanga kwa magazi kwa diastolic (DBP) pafupifupi kunachepa kuchoka pamtengo woyambira ndi 4.5 mmHg. ndi 4.8 mmHg m'magulu a telmisartan, 1 mg / kg ndi 2 mg / kg, motsatana.

Kusintha kudalira mlingo.

Mbiri ya chitetezo idafanana ndi yomwe imachitika mwa achikulire odwala.

Mlingo ndi makonzedwe

Chithandizo cha ochepa matenda oopsa

Mulingo woyamwa wabwino ndi 40 mg kamodzi tsiku lililonse.

Muzochitika zomwe kuthamanga kwa magazi sikukwaniritsidwa, mlingo wa MIKARDIS ukhoza kuchuluka mpaka 80 mg kamodzi patsiku.

Mukachulukitsa mlingo, muyenera kukumbukiranso kuti mphamvu yotsalira ya antihypertgency nthawi zambiri imakwaniritsidwa patatha milungu inayi mpaka isanu ndi itatu mutayamba chithandizo.

Telmisartan ikhoza kugwiritsidwa ntchito limodzi ndi thiazide diuretics, mwachitsanzo, hydrochlorothiazide, yomwe kuphatikiza ndi telmisartan imakhala ndi chowonjezera chama hypotensive.

Odwala omwe ali ndi matenda oopsa oopsa, mlingo wa telmisartan ndi 160 mg / tsiku (makapisozi awiri a MIKARDIS 80 mg) komanso osakanikirana ndi hydrochlorothiazide 12.5-25 mg / tsiku anali wololera komanso wogwira ntchito.

Kupewa matenda a mtima komanso kufa

Mlingo womwe umalimbikitsa ndi 80 mg kamodzi tsiku lililonse.

Sizinatsimikizike ngati Mlingo womwe uli pansi pa 80 mg ndiwothandiza kuchepetsa kuchepa kwa mtima ndi kufa.

Pachigawo choyambirira chogwiritsa ntchito telmisartan popewa kuthamanga kwa mtima ndi kufa, ndikofunikira kuti magazi azithamanga (BP), ndipo kuwongolera kwa BP kungafunikire ndi mankhwala omwe amachepetsa kuthamanga kwa magazi.

MIKARDIS imatengedwa mosasamala kanthu za chakudya.

Kusintha kwa odwala omwe ali ndi vuto la aimpso sikofunikira, kuphatikiza odwala pa hemodialysis. Telmisartan samachotsedwa m'magazi panthawi ya kuwonongeka kwa magazi.

Odwala omwe ali ndi chiwindi chochepa kwambiri, ntchito ya tsiku ndi tsiku sayenera kupitirira 40 mg kamodzi patsiku.

Kusintha kwa Mlingo sikofunikira.

Chitetezo ndikuyenda bwino kwa kugwiritsa ntchito kwa MIKARDIS mwa ana ochepera zaka 18 sikunakhazikitsidwe.

Kupanga ndi mankhwala a Mikardis

Chofunikira chachikulu pa mankhwalawa ndi Telmisartan. Piritsi limodzi limakhala ndi 80, 40 kapena 20 mg. Omwe amachokera ku mankhwalawa omwe amasintha kuyamwa kwa gawo lalikulu ndi meglumine, sodium hydroxide, polyvidone, sorbitol, magnesium stearate.

Mikardis ndi wotsutsana ndi angiotensin-2 hormone receptor antagonist. Hormone iyi imawonjezera mamvekedwe a makoma a mtima, zomwe zimapangitsa kuchepa kwa lumen ya ziwiya. Telmisartan mu kapangidwe kake kama kemikali ndi ofanana ndi subspecies a angiotensin AT1 receptors.

Atalowa m'thupi, Mikardis amapanga mgwirizano ndi AT1 receptors ndipo izi zimapangitsa kuti angiotensin asamuke, ndiye kuti, chomwe chikuwonjezera kuchuluka kwa magazi amachotsedwa. Telmisartan imayambitsa kutsika kwa systolic ndi diastolic, koma chinthu ichi sichisintha mphamvu komanso kuchuluka kwa minofu yamtima.

Kugwiritsa ntchito koyamba kwa Mikardis kumapangitsa kuti magazi azikhala pang'onopang'ono - amayamba kuchepa maola atatu.Mphamvu ya antihypertensive mutatha kumwa mapiritsi imawonedwa kwa tsiku limodzi, ndiye kuti, kuti mupanikizike, muyenera kumwa mankhwalawo kamodzi kokha patsiku.

Kutsika kwakukulu komanso kosalekeza kwa kupanikizika kumachitika pakatha milungu inayi mpaka isanu kuyambira pachiyambireni cha mankhwala ndi Mikardis. Ngati mankhwalawo atathetsedwa modzidzimutsa, mphamvu yochotsera sikukutikika, ndiye kuti, kuthamanga kwa magazi sikubwereranso modukiziratu kwambiri, nthawi zambiri izi zimachitika mkati mwa milungu ingapo.

Zigawo zonse za Mikardis, zikagwiritsidwa pakamwa kuchokera m'matumbo, zimamwa kwambiri mwachangu, bioavailability ya mankhwalawa imafika pafupifupi 50%. Pazitali kwambiri yogwira ntchito ya plasma imadziwika pambuyo pa maola atatu.

Kupanga mapangidwe kumachitika poyankha telmisartan ndi glucuronic acid, ma metabolites omwe amayamba alibe ntchito. Kutha kwa theka la moyo kumapangitsa maola opitilira 20. Mankhwala omwe adakonzedwamo amachotsedwera limodzi ndi ndowe, osakwana 2% ya mankhwalawa amamasulidwa ndi mkodzo.

Mukamagwiritsa ntchito

Mankhwala Mikardis adapangidwa kuti azitha matenda oopsa. Madokotala ena amapereka mankhwala kwa odwala azaka zopitilira 55 omwe ali pachiwopsezo chachikulu chotenga matenda oopsa a mtima ogwirizana ndi matenda oopsa.

Kuphatikiza pa Mikardis wokhazikika, Mikardis Plus imapezekanso. Mankhwalawa, kuphatikiza telmisartan, ali ndi zowonjezera za 12.5 mg za hydrochlorothiazide, mankhwalawa ndi okodzetsa.

Kuphatikizidwa kwa okodzetsa ndi chidwi cha angiotensin kumakupatsani mwayi wopezeka ndi zotsatirapo zabwino za mankhwalawo. A diuretic zotsatira zimachitika pafupifupi maola awiri mutamwa mapiritsi. Malangizo a mycardis kuphatikiza amawonetsa kuti mankhwalawa amalembedwa ngati sizingatheke kukwaniritsa kukakamizidwa komwe mukumwa mankhwala a antihypertensive.

Pamene Mikardis amatsutsana

Mikardis 40 ilinso ndimalingana ndi mapiritsi ofanana ndi mapiritsi okhala ndi chinthu china chogwira ntchito. Kuchiza ndi antihypertensive mankhwala sikuchitika:

• Ngati hypersensitivity ikuluikulu kapena yowonjezera ya mankhwala ikhazikitsidwa,
• Zoyipa zonse za pakati ndi poyamwitsa,
• Ngati wodwala ali ndi biliary traology yomwe imakhudza patency yawo,
• Ndi kuphwanya kwakukulu pakugwira ntchito kwa chiwindi ndi impso,
• Ndi chibalo cha fructose chosalolera.

Mikardis analogues iyenera kufunidwa pochiza matenda oopsa kwa achinyamata ndi ana, izi zimachitika chifukwa chakuti zotsatira za telmisartan pazinthu zosapangika sizinakhazikitsidwe.

Malangizo a mycardis kuphatikiza akuwonetsa kuti, kuwonjezera pa contraindication pamwambapa, mankhwalawa sayenera kutumizidwa kwa odwala omwe ali ndi Reflexory hypercalcemia ndi hypokalemia, omwe ali ndi vuto lactase komanso tsankho lactose ndi galactose.

Pali zotsutsana pamtundu wa myarkis mankhwala. Ndiye kuti, adotolo ayenera kusamala ndikuyamba kulandira chithandizo chamankhwala ochepetsedwa, ngati mbiri ya matenda oopsa ndi:

• Hyponatremia kapena hyperkalemia,
• CHD - ischemia wamtima,
• Matenda a mtima - kulephera kosalekeza, ma stenosis, mtima,
• Stenosis ya mitsempha yonse ya impso - ngati wodwalayo ali ndi impso imodzi, ayenera kusamala popereka mankhwala ngati pali stenosis yamitsempha yamagazi yokha.
• Kuthetsa magazi chifukwa cha kusanza ndi kutsegula m'mimba,
• Chithandizo cham'mbuyomu ndi okodzetsa,
• Kubwezeretsa pambuyo pochotsa impso.

Zotsatira zoyipa

Ndemanga za Mycardis sizikhala zabwino nthawi zonse. Odwala ena amawona mawonekedwe osiyanasiyana osasangalatsa pamakhalidwe oyenera, ndipo chitukuko chawo chimatengera mlingo wa mankhwalawo, zaka za wodwalayo komanso kupezeka kwa ma concomitant pathologies. Nthawi zambiri, zosintha zotsatirazi ndizotheka:

• Chizungulire, kupweteka mutu, kutopa ndi nkhawa, kukhumudwa, kusowa tulo, nthawi zina, kukomoka.
• Kuchulukana kwa kupuma kwa matenda opatsirana omwe amapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, zomwe zimayambitsa pharyngitis, sinusitis, bronchitis ndi chifuwa cha paroxysmal.
• Matenda a dyspeptic mu mawonekedwe a mseru, m'mimba kukokana, ndi m'mimba. Mwa odwala ena, mayeso amawonetsa kuwonjezeka kwa michere ya chiwindi.
• Hypotension, kupweteka pachifuwa, tachycardia, kapena mosemphana ndi bradycardia.
• Kupweteka kwa minofu, arthralgia, kupweteka kwa msana.
• Mavuto owononga a genitourinary thirakiti, kusungunuka kwa madzi mthupi.
• Thupi lawo siligwirizana mu mawonekedwe a khungu totupa, urticaria, angioedema, kuyabwa, erythema.
• Mu zasayansi mayeso - hyperkalemia ndi zizindikiro za kuchepa magazi.

Maphunziro a Prequinical a Mikardis anakhazikitsa mphamvu ya fetotoxic ya mankhwala. Pankhaniyi, ndikosayenera kugwiritsa ntchito mankhwalawa panthawi yonse yovomerezeka.

Ngati kutenga pakati kukonzekera, ndiye kuti wodwala, malinga ndi lingaliro la dokotala, asinthana ndi mankhwala otetezeka a antihypertensive. Ngati mayi ali ndi pakati pamankhwala a Mikardis, kuyimitsidwa kwa mankhwalawa kumayimitsidwa nthawi yomweyo.

Zolemba ntchito

Mankhwala a Mikardis ayenera kufotokozedwa ndi dokotala ndipo angagwiritsidwe ntchito palokha komanso ndi mankhwala ena omwe machitidwe awo cholinga chake ndi kukonza kayendedwe ka mtima. Wopanga amalimbikitsa kudya tsiku lililonse kuti azikhala ndi piritsi limodzi la Mikardis lokhala ndi 40 mg ya chinthu chomwe chikugwira ntchito.. Koma ziyenera kukumbukiridwa kuti odwala omwe ali ndi matenda oopsa, nthawi zambiri amakhala osokoneza bongo akamamwa mankhwala 20 mg.

Kusankhidwa kwa njira yochizira kumachitika kwa masabata anayi. Zimatenga nthawi yayitali kuti mankhwalawa asonyeze mphamvu yake yonse yochizira. Ngati zotsatira zomwe mukufuna sizikuchitika panthawiyi, ndiye kuti wodwala akulimbikitsidwa kuti atenge Mikardis 80, piritsi limodzi patsiku. M'mitundu ikuluikulu ya matenda oopsa, 160 mg wa telmisartan ikhoza kutumizidwa, ndiye kuti, itenge mapiritsi awiri a 80 mg aliyense.

Nthawi zina, sizingatheke kuti magazi achulukane mukamagwiritsa ntchito mankhwala amodzi. Dokotala amalimbikitsa odwala oterowo kuti agule Mikardis kuphatikiza, chifukwa cha okodzetsa omwe amaphatikizidwa ndi izi, kupanikizika kumachepa mwachangu komanso bwino. Mlingo wa mankhwala ophatikiza umasankhidwa malinga ndi kuwonongeka kwa matenda oopsa. Ndemanga ya mycardis kuphatikiza imatsimikizira mphamvu yake yotchedwa antihypertensive.

Mankhwalawa amatengedwa nthawi iliyonse yamasana, kudya sikumakhudzanso digestibility ya zinthu za mankhwala. Kutalika kwakanthawi kovomerezeka ndi dokotala, kutengera thanzi la wodwalayo, dokotala atha kukuthandizani kuti musinthe 20 mg.

Momwe Mikardis amathandizira ndi mankhwala ena

Ngati mukufunika kugwiritsa ntchito mankhwala osokoneza bongo ndi telmisartan, dokotala ayenera kudziwa zomwe wodwala akumwabe. Ndi makonzedwe amodzi a mankhwala angapo, zotsatira zawo kapena zotsatira za Mikardis zitha kuchuluka.

• Telmisartan imakulitsa mphamvu za antihypertensive zamankhwala ena ndizofanana,
• Ndi chithandizo chanthawi yomweyo ndi Digoxin ndi Mikardis, kugwiritsidwa ntchito kwa zigawo za mankhwala oyamba kumawonjezeka
• Kuchuluka kwa Ramipril kumawonjezera pafupifupi nthawi 2.5, koma kufunikira kwakukhudzana ndi mankhwalawa sikunadziwike,
• Kuchulukitsa kwa zinthu zomwe zimakhala ndi lithiamu kumawonjezeka, komwe kumayendetsedwa ndi kuwonjezereka kwa poizoni m'thupi.
• Ndi munthawi yomweyo makonzedwe a NSAIDs ndi telmisartan odwala matenda am'madzi, chiwopsezo cha matenda a impso ndi kuchepa kwa hypotensive zotsatira za Mikardis ukuwonjezeka.

Zomwe zimagwiritsidwa ntchito pakuwongolera njira zovuta

Malangizo omwe adaphatikizidwa ogwiritsira ntchito Mikardis 80 mg ndi 40 mg akuwonetsa kuti palibe kuyesedwa kwapadera komwe kumachitika momwe kumwa mankhwalawa kumathandizira chidwi cha munthu ndi kuthamanga kwa zomwe akuchita. Komabe, mukamamwa mankhwala osokoneza bongo, muyenera kukumbukira kuti mankhwala omwe ali mgululi nthawi zambiri amachititsa kugona. Ngati ogwira ntchito omwe amagwiritsidwa ntchito ndikuthandizira njira zovuta ali ndi zofananira, ndiye kuti ayenera kupatsidwa fanizo la mycardis.

Zosunga

Mankhwala amayenera kusungidwa pomwe kupezeka kwake kwa ana sikuphatikizidwa. Kutentha pamalo osungirako sikuyenera kukhala kokulirapo kuposa madigiri 30. Mapiritsi okhala ndi mulingo wa 40 ndi 80 mg amasungidwa popanda kuphwanya umphumphu wa chithupsa osaposa zaka 4 kuyambira tsiku lomwe adapanga. 20 mg mapiritsi ali ndi lalifupi lalifupi moyo 3 zaka.

Mtengo wa Mikardis zimatengera muyeso wa zomwe zimagwiritsidwa ntchito mu mankhwala. Mutha kugula Mikardis 40 ndi mapiritsi 14 pa paketi imodzi ndi ma ruble 500 ndi ena. Mutha kugula Mikardis 80 ndi mapiritsi 28 mumasitolo pamitengo yama ruble 950. Mtengo wa mycardis kuphatikiza mapiritsi 28 uyambira pa 850 rubles.

Nthawi zambiri, ndemanga za mankhwala a Mikardis ndi zabwino - anthu omwe amagwiritsa ntchito mankhwalawa amakhala osaneneka komanso amayamba kuthamanga kwa magazi. Koma zochulukira zambiri za mankhwalawa zimayimitsidwa ndi mtengo wake wokwera.

Dokotala asankhe ma analogi a mycardis otsika mtengo, omwe ndi odziwika bwino omwe ali ndi vuto lofanana ndi awa: