Matenda a Steroid

Nthawi zambiri, asayansi monga zifukwa zopititsa patsogolo matendawa amatchula hypothalamic-pituitary syndrome ndi matenda ake a Itsenko-Cushing. Ngati chiopsezo cha pituitary ndi hypothalamus chasokonekera, ndiye kuti vuto la mahomoni limapezeka m'thupi. Izi, zimayambitsa kuchepa kwa chizindikiro cha kukana kwa maselo a cell kupita ku insulin. Matenda ofala kwambiri pamenepa ndi matenda a Itsenko-Cushing.

Amadziwika ndi kuchuluka kwambiri kwa kaphatikizidwe ka corticosteroids ndi adrenal cortex. Pakadali pano, njira zenizeni zopangira matendawa sizinakhazikitsidwe. Asayansi akuwona kulumikizana komwe kumachitika pakati pa amayi pakati pa pakati ndi izi. Si chinsinsi kuti munthawi yamatumbo, mphamvu yamafuta amkazi imagwira ntchito mosiyanasiyana ndipo kusayenerana kwa mahomoni ndizotheka.

Tiyenera kudziwa kuti chodabwitsa cha matenda a Itsenko-Cushing ndi kusapezeka kwa zosokoneza mu kapamba, zomwe zimapanga insulin. Uku ndiye kusiyana kwakukulu pakati pa matenda a shuga a steroid ndi matenda apamwamba. Tanena kale kuti chifukwa cha izi zimatha kukhala mankhwala makamaka corticosteroids. Amawonjezera kuchuluka kwa shuga mu chiwindi, komwe kumabweretsa glycemia.

Matenda a Steroid nthawi zambiri amapezeka mwa anthu omwe ali ndi poizoni woopsa. Poterepa, minofuyo samamwa glucose mwachangu monga momwe amafunikira. Ngati vuto la chithokomiro cha wodwala limaphatikizidwa ndikupanga matenda a shuga, ndiye kuti matenda a shuga omwe amadalira insulin amakula. Corticosteroids imasokoneza ntchito ya kapamba ndipo imalepheretsa kugwira ntchito kwa insulin. Zotsatira zake, thupi limakakamizidwa kugwira ntchito kufikira malekezero ake. Nthawi yochulukirapo ya corticosteroids imagwiritsidwa ntchito, imakhala yowopsa kwambiri yolephera kapamba.

Kodi ma steroid amathandizira bwanji matenda a shuga - pali kulumikizana?

Masiku ano, pafupifupi akatswiri onse ochita masewera olimbitsa thupi amagwiritsa ntchito anabolic steroids. Popanda mankhwalawa, ndizovuta kudalira zotsatira zabwino. Malinga ndi asayansi ambiri, kugwiritsa ntchito AAS kumangoika munthu pachiwopsezo. Tiyeni tiyesere kudziwa ngati pali mgwirizano pakati pa ma steroid ndi matenda ashuga? Madokotala akutsimikiza kuti ilipo komanso zoopsa zomwe zingayambitse matenda a shuga omwe amadalira insulin ndi okwera kwambiri.

Ngakhale kuti anabolic steroid amagwiritsidwa ntchito nthawi zambiri pamasewera, m'malo mwa corticosteroids, zovuta pa adrenal cortex sizingapeweke. Izi zimabweretsa kuwonjezeka kwa minulin insulin kukana. Titha kunena kuti ubale pakati pa ma steroid ndi matenda a shuga ungatengedwere mbali ziwiri:

Njira yoyamba ya chitukuko cha matendawa

Njira yachiwiri yopezera matendawa - Amawonjezera kukana minofu. Potsutsana ndi izi, matenda a shuga omwe amadalira insulin amatha.

Kodi mankhwala a mahomoni amakhudza bwanji matenda ashuga?

Mahomoni ena oletsa kubereka omwe amagwiritsidwa ntchito ndi amayi amatha kuyambitsa matenda a shuga a 2. Ndizachidziwikire kuti mahomoni opanga amatha kusokoneza dongosolo la endocrine. Nthawi zina zomwe zimayambitsa kukula kwa matendawa zimakhala prednisone, yaprilin, ndi zina. Mwachilungamo, tikuwona kuti kukhudzika kwa minofu kumapangitsa insulini pazinthu zotere. Matenda a metabolism omwe amayamba chifukwa cha mankhwalawa nthawi zambiri samatchulidwa.

Koma chiopsezo chokhala ndi matenda a shuga a steroid mukamagwiritsa ntchito thiazide diuretics ndizochulukirapo. Kumbukirani kuti mankhwala omwe ali mgululi akuphatikizapo hypothiazide, Navidrex, dichlothiazide ndi ena. Ngati mankhwala a lupus erythematosus, pemphigus, eczema, nyamakazi yokhala ndi nyamakazi komanso mphumu, corticosteroids amagwiritsidwa ntchito nthawi zambiri. Tanena kale kuti mankhwalawa amatha kuyambitsa zovuta zazikulu za metabolic ndikupangitsa kukula kwa matenda ashuga. Ngati nthawi yomweyo beta-maselo a kapamba akapuma kuti awonongeke, ndiye kuti matendawa amakhala ndi fomu yodalira insulin.

Zizindikiro za Steroid Diabetes

Zizindikiro za matendawa zimakhala ndi zizindikiro za matenda ashuga, onse oyamba komanso achiwiri. Tanena kale kuti mankhwala a mahomoni amatha kuwononga ma cell a beta a kapamba ndipo thupi silingathe kuthana ndi ntchito yomwe yapatsidwa. Nthawi inayake, kupanga insulin kudzachepa.

Nthawi yomweyo, chizindikiro cha kukana minyewa chimatha kuchuluka mthupi. Pancreas ikangoletsa kubisala kwa insulin, shuga yodalira insulin imayamba kukula. Mwa zina zazikulu za matendawa, zitatu zimatha kusiyanitsidwa:

Kumva ludzu pafupipafupi.
Kutsika kwakuthwa mu magwiridwe antchito.
Pafupipafupi komanso mopatsa chidwi diuresis.

Chodabwitsa cha mtundu uwu wa matenda ashuga ndikuti zizindikiro zomwe zatchulidwazi sizitchulidwa. Zotsatira zake, munthuyo samalangiza. Kuti thupi layamba kale kudwala ndipo siliyenera kupita kukaonana ndi dokotala. Odwala otere, kuchepa thupi kumachitika kawirikawiri. Ngakhale mayeso a labotala samapereka zotsatira zoyenera nthawi zonse, chifukwa kuchuluka kwa shuga m'magazi kumatha kukhala koyenera.

Zomwe zimayambitsa matenda a shuga a Steroid

Amithenga am'magulu a Hormonal amapangidwa mwachilengedwe ndi ziwalo za adrenal ndi ziwalo zoberekera. Amasokoneza chitetezo chathupi ndipo amagwiritsidwa ntchito pochiza matenda otsatirawa a autoimmune,

Kuti akwaniritse cholinga chawo, corticosteroids amatsata zotsatira za cortisol, timadzi timene timatulutsa impso, motero zimapangitsa mkhalidwe wopsinjika chifukwa cha kuchuluka kwa magazi ndi glucose.

Komabe, palimodzi ndi phindu, zinthu zopangidwa ndi zinthu zina zimakhala ndi zotsatira zoyipa, mwachitsanzo, kunenepa kwambiri ndi kuwonda kwa mafupa mukamatengedwa nthawi yayitali. Odwala a Corticosteroid atengeka mosavuta ndi chitukuko cha dziko lotengeka.

Pakukhudzidwa kwambiri kwa m'magazi, maselo opanga insulin amatulutsa timadzi tambiri kuti timatseke shuga. Chifukwa chake, umasiyanitsa shuga mkati mwa yokhazikika kuti thupi lonse lizigwira ntchito.

Mu pathological mkhalidwe wa mitundu iwiri, ma steroid amapanga shuga. Amachulukitsa glycemia m'njira zitatu:

Kuletsa zochita za insulin.
Wonjezerani shuga.
Kupanga kwamphamvu kwa chiwindi.

Zinthu zophatikizika zomwe zimagwiritsidwa ntchito pochiza mphumu sizimakhudza shuga. Komabe, mulingo wake umakwera m'masiku ochepa ndipo udzasiyanasiyana kutengera nthawi, mlingo ndi mtundu wa mahomoni:

Zotsatira zamankhwala akumamwa zimathera patatha maola 48 mutachotsedwa,
Zotsatira za jakisoni zimatha masiku atatu mpaka 10.

Atayimitsa kugwiritsa ntchito ma steroid, glycemia imayamba kuchepa, komabe, anthu ena amatha kudwala matenda amtundu wa 2, omwe amayenera kuthandizidwa pa moyo wonse. Matendawa amtundu wamtunduwu amakula ndikugwiritsa ntchito mankhwala osokoneza bongo kwa nthawi yayitali (oposa miyezi 3).

- Ichi ndi endocrine matenda omwe amapezeka chifukwa cha kuchuluka kwamadzi am'magazi a adrenal cortex komanso kuphwanya kagayidwe kazakudya. Amawonetsedwa ndi zizindikiro za hyperglycemia: kutopa msanga, ludzu lochulukirapo, kukodza kwambiri, kuperewera kwa thupi, chidwi chambiri. Kuzindikira mwatsatanetsatane kumatengera kuwonekera kwa labotale ya hyperglycemia, kuwunika kwa kuchuluka kwa ma steroid ndi ma metabolites awo (mkodzo, magazi). Chithandizo cha matenda a shuga a steroid chimaphatikizira kusiya kapena kuchepetsa kuchuluka kwa glucocorticoids, opaleshoni yochepetsera kupanga mahomoni a corticosteroid, komanso mankhwala antidiabetesic.

Zizindikiro za Steroid Diabetes

Chithunzi cha chipatala chikuyimiriridwa ndi matenda a matenda ashuga - polydipsia, polyuria ndi kutopa. Mwambiri, zizindikiro sizimatchulidwa kwenikweni kuposa mtundu wa 1 shuga. Odwala amawona kuwonjezeka kwa ludzu, pakamwa lowuma kosalekeza. Kuchuluka kwa madzimadzi omwe amamwa kumawonjezeka kangapo, mpaka malita 4-8 patsiku. Mkuntho sutha ngakhale usiku. Kulakalaka kumakulitsidwa, kulemera kumakhalabe chimodzimodzi kapena kumawonjezeka. Yesetsani kukodza. Malita atatu a mkodzo amachotsedwa patsiku; enursis amakula ana ndi okalamba. Odwala ambiri amadwala matenda osowa tulo, amakhala otopa masana, sangathe kulimbana ndi zochitika zawo, komanso kugona.

Kumayambiriro kwa matendawa, Zizindikiro zimachuluka msanga, monga matenda amitundu 1: kukhala bwino, kupweteka mutu, kusokonekera, kutentha kwayamba. Njira yayitali ya matendawa imayendera limodzi ndi mawonekedwe a kuyabwa kwa pakhungu ndi mucous nembanemba. Nthawi zambiri pamakhala zotupa, zotupa, mabala samachiritsa kwa nthawi yayitali. Tsitsi limakhala louma, misomali imakhala yowonjezera ndikusweka. Kuwonongeka kwa magazi ndi kufalikira kwamanjenje kumawonetsedwa ndi kuphwanya kwa miyendo, miyendo, kumva thukuta, kuwotcha komanso kutentha m'miyendo, nthawi zambiri kumilingo.

Mavuto

Hyperglycemia yomwe imatenga nthawi yayitali imayambitsa matenda a shuga - kuwonongeka kwa ziwiya zazikulu ndi zazing'ono. Kusokonezeka kozungulira mu ma capillaries a retina kumawonetsedwa ndi kuchepa kwa masomphenya - matenda ashuga retinopathy. Ngati minyewa yolumikizana ndi impso ikuvutikira, ndiye kuti ntchito yake yosefaipa imakulirakulira, kutupa kumachitika, kuthamanga kwa magazi kumadzuka ndipo matenda a shuga amayamba. Zosintha m'matumbo akuluakulu zimayimiridwa ndi atherosulinosis. Zilonda zoopsa kwambiri zam'matumbo a mtima ndi m'munsi. Kusagwirizana kwa ma electrolyte komanso kusakwanira kwa magazi ku minyewa yamanjenje kumayambitsa chitukuko cha matenda ashuga. Itha kuwonetsedwa ndi kukhudzidwa, dzanzi la miyendo ndi zala m'manja, kulakwitsa kwa ziwalo zamkati, kupweteka kwamitundu yosiyanasiyana.

Zizindikiro

Omwe ali pachiwopsezo chotenga mtundu wa matenda amtundu wa sodium ndi anthu omwe ali ndi hypercorticism ya ambulera. Kafukufuku wambiri wamagulu a glucose kuti adziwe hyperglycemia amawonetsedwa kwa odwala omwe ali ndi matenda a Cushing, zotupa za adrenal, anthu omwe amamwa mankhwala a glucocorticoid, thiazide diuretics, kulera kwa mahomoni. Kuunika kwathunthu kumachitika ndi endocrinologist. Njira zofufuzira mwapadera ndizophatikiza:

Kuthamanga mayeso a shuga . Odwala ambiri amakhala ndi glucose wabwinobwino kapena wowonjezera pang'ono wamagazi. Mfundo zomaliza nthawi zambiri zimakhala pamtunda kuchokera pa 5-5.5 mpaka 6 mmol / L, nthawi zina 6.1-6.5 mmol / L ndi kukwera.
Mayeso a kulolera a glucose. Kuyeza glucose patatha maola awiri mutanyamula chakudya kumapereka chidziwitso chokwanira chokhudza matenda ashuga komanso kudziwa kwake. Zizindikiro kuyambira 7.8 mpaka 11.0 mmol / L zikuwonetsa kuphwanya kulekerera kwa shuga, komanso matenda ashuga - zoposa 11.1 mmol / L.
Mayeso a 17-KS, 17-OKS . Zotsatira zake zimatithandizira kuti tizitha kuzindikira zomwe zimachitika mu cell mwa adrenal cortex. Zolemba pazolemba ndi mkodzo. Kuwonjezeka kwa mawonekedwe a 17-ketosteroids ndi 17-hydroxycorticosteroids.
Kafukufuku wa mahomoni . Kuti mupeze zowonjezera pazantchito za pituitary ndi adrenal cortex, kuyesedwa kwa mahomoni kungachitike. Kutengera ndi matenda omwe amayambitsidwa, kuchuluka kwa cortisol, aldosterone, ACTH kutsimikiza.

Chithandizo cha Matenda a Steroid

Etiotropic chithandizo ndikuchotsa zomwe zimayambitsa hypercorticism. Nthawi yomweyo, njira zomwe zimapangidwira kubwezeretsa ndikusunga Normoglycemia, kukulitsa chidwi cha minyewa mpaka kuchitapo kanthu ka insulin, ndikulimbikitsa ntchito ya preserved-cell yomwe ikusungidwa ikuchitika. Ndi njira yophatikizidwa, chisamaliro chachipatala cha odwala chimachitika m'mbali zotsatirazi:

Otsika milingo corticosteroid . Ndi endo native hypercorticism, chithandizo cha matenda oyambitsidwa chimakonzedwanso. Ngati kusintha kwa mankhwalawa kwa mankhwalawa sikothandiza, kufunsa kwa maopaleshoni kungathetsedwe - kuchotsedwa kwa gren adrenal gortical, gortical gawo la adrenal gasm. Masautso a mahomoni a steroid amachepa, kuchuluka kwa shuga m'magazi kumachitika. Ndi hypercorticism ya kunja, mankhwalawa omwe amachititsa kuti shuga ya shuga ipitikize kapena m'malo mwake. Ngati ndizosatheka kuletsa glucocorticoids, mwachitsanzo, mu mphumu yayikulu ya bronchial, mahomoni a anabolic amapatsidwa mphamvu kuti athe kusintha zotsatira zawo.
Mankhwala kukonza hyperglycemia . Mankhwala amasankhidwa payekha, poganizira etiology, gawo lake, kuuma. Ngati kapamba akhudzidwa, maselo a beta amakhala pang'ono kapena atakhazikika kwathunthu, ndiye kuti mankhwala a insulin ndi omwe amakhazikitsidwa. Mwa matenda ofatsa, kuteteza minyewa ya glandular komanso kusinthika kwa maselo ku insulini, othandizira pakamwa ndi hypoglycemic, mwachitsanzo, kukonzekera kwa sulfonylurea. Nthawi zina odwala amawonetsedwa pogwiritsa ntchito mankhwala a insulin ndi hypoglycemic.
Zakudya za antidiabetes . Odwala ambiri amawonetsedwa ngati achire othandizira kudya No. 9. Zakudyazo zimapangidwa m'njira yoti mankhwala azisamba azikhala ndi chakudya, samatsitsimutsa hyperglycemia ndipo muli zinthu zonse zofunika. Mfundo zachakudya zamafuta ochepa zimagwiritsidwa ntchito: magwero a mafuta opepuka samachotsedwa - maswiti, makeke, zakumwa zotsekemera. Mapuloteni ndi zakudya zamafuta ambiri zimakhazikika muzakudya. Mndandanda wa glycemic umatengedwa. Kudya kumachitika m'magawo ang'onoang'ono, nthawi 5-6 patsiku.

Zotsogola ndi kupewa

Matenda a Steroid, monga lamulo, amapitilira modekha ndipo ndi osavuta kuchiza kuposa matenda ashuga amtundu woyamba ndi wachiwiri. Kukula kwake kumadalira zomwe zimayambitsa kukula kwa hypercorticism, nthawi zambiri zimakhala zabwino. Kupewa kumatengera chithandizo chanthawi komanso chokwanira cha matenda a Cushing komanso matenda a adrenal chotupa, kugwiritsa ntchito moyenera glucocorticoids, thiazide diuretics komanso njira yolerera pakamwa. Anthu omwe ali pachiwopsezo ayenera kuwunika magazi a magazi pafupipafupi. Izi zimakuthandizani kuzindikira zovuta zamatenda a carbohydrate pamlingo wa prediabetes, sinthani chithandizo chachikulu, yambani kutsatira mfundo za zakudya.

Second matenda a shuga - matenda opezeka chifukwa cha matenda enaake kapena mankhwala. Matenda a shuga a steroid amakula mwa anthu omwe magazi awo a mahomoni a steroid amawonjezeka.

Matenda a shuga a Steroid amakhalanso odalira insulin. Amayamba mwa anthu chifukwa chambiri cha kuchuluka kwa corticoids m'magazi - ma adrenal mahomoni. Matenda a Steroid amakula modutsa zovuta za adrenal gland pathologies. Komabe, nthawi zambiri matendawa amakumananso ndi vuto atatha kumwa mankhwala a mahomoni. Chodabwitsa cha matenda awa ndikuti zimachitika mwapang'onopang'ono. Zizindikiro zapadera za matendawa sizitchulidwa.

Zomwe zimayambitsa matenda a shuga a Steroid

Cholinga chofunikira kwambiri cha kupezeka kwa matenda a shuga a steroid ndi hypothalamic-pituitary syndromes, komanso matenda a Itsenko-Cushing.Kuphwanya kwa hypothalamus ndi pituitary gland kumayambitsa kusalinganika kwa mahomoni ena m'thupi ndipo, chifukwa chake, amasintha pakukaniza kwa maselo ndi minyewa kupita ku insulin. Mwa zina mwa matenda otere, matenda a Itsenko-Cushing ndi ofala kwambiri.

Matendawa amadziwika ndi kupanga kwambiri hydrocortisone, mahomoni a adrenal. Cholinga chophwanya lamulo sichinadziwikebe bwinobwino. Amadziwika kuti mwa amayi pali ubale pakati pa zomwe zimachitika ndi matendawa komanso pakati. Kusagwirizana pakati pamahomoni m'thupi kumabweretsa chakuti ma cell amthupi samayankha insulin.

Ndi matenda a Itsenko-Cushing, palibe zovuta kutchulidwa pakugwira ntchito kwa kapamba. Izi zimasiyanitsa kwambiri shuga ya steroid kuchokera ku mitundu yake ina.

Chimodzi mwazinthu zomwe zimapangitsa kukula kwa matenda osokoneza bongo ndi kugwiritsa ntchito glucocorticosteroids. Amathandizira kukulitsa mapangidwe a glycogen mu chiwindi. Chifukwa chake wodwalayo ali ndi glycemia.

Matenda a Steroid amakumananso ndi odwala omwe ali ndi poizoni woopsa (matenda a Bazedova, matenda a Graves). Nthawi yomweyo, kukonzanso kwa glucose ndi minofu kumawipira. Pankhani ya kuphatikizika kwa ntchito ya chithokomiro chamtunduwu ndi matenda a shuga, kufunikira kwa insulin kumawonjezeka kwambiri ndipo kukana insulini kumayamba.

Mahomoni a Corticosteroid amachita m'njira ziwiri pa thupi. Amasokoneza kapamba ndipo amathandizira insulin. Ichi ndichifukwa chake gawo lofunikalo limagwira, makamaka, pamphepete mwa zotheka. Pambuyo pakuchiritsa kwambiri kwa mahomoni, zovuta za metabolic nthawi zambiri zimatha.

Zotsatira za ma steroid pa matenda ashuga

Ochita masewera ambiri amatenga anabolic steroids kuti minofu ikule msanga. Ali pachiwopsezo, monga kafukufuku wambiri akusonyeza kuti othamanga otere amatha kukhala ndi shuga osadalira insulin. Ubale wotere umakhalapo chifukwa mahomoni amakula kwambiri kuchuluka kwa mahomoni amtundu wa glucocorticoid. Ma ricochet amachititsa insulin kukana.

Mukamamwa mahomoni a steroid, shuga m'masewera othamanga amatha kukula m'njira ziwiri. Poyambirira, kusokonezeka kwa kapamba kumachitika, ndipo kumatulutsa insulin yochepa kwambiri. Matenda a shuga 1 amayamba.

Nthawi ina, kapamba amatulutsa kuchuluka kwa insulini, koma maselo ndi minyewa yathupi lake zimamvekera pang'ono. Ili ndiye mtundu wa shuga wodziimira payekha.

Mankhwala a mahomoni ndi matenda ashuga

Mankhwala ena a mahomoni omwe amayi amatenga ngati njira zakulera amathandizira kwambiri kutenga matenda ashuga a 2. Izi zimachitika, makamaka, chifukwa chakuti mahomoni omwe amagwiritsidwa ntchito ngati mankhwalawa amasintha kuchuluka kwa mahomoni.

Nthawi zina, zimathandizira kukulitsa matenda a shuga ndi prednisolone, anaprilin ndi mankhwala ena. Komabe, kuphwanya thupi komwe kumapangitsa chidwi cha insulin muzochitika zotere ndizosowa kwambiri: kusokonezeka kwa metabolic sikumatchulidwa kotero kuti kumapangitsa kuti shuga ikule.

Matenda a shuga a Steroid amathanso chifukwa cha thiazide diuretics - Dichlothiazide, Hypothiazide, Nephrix, Navidrex ndi ena.

Glucocorticoids omwe amagwiritsidwa ntchito pochiza mphumu, nyamakazi yodutsa matenda am'mimba, systemic lupus erythematosus, pemphigus ndi eczema zingayambenso kusokonezeka kwa metabolic komanso kuyambitsa matenda osokoneza bongo. Nthawi zina mankhwalawa amatha kupatsira ma cell a pancreatic beta. Poterepa, amalankhula za chitukuko.

Mfundo zachikhalidwe zamankhwala

Njira zochizira matenda amtunduwu ndizofanana ndi matenda ashuga. Zimatanthauzanso zomwe wodwala ali nazo. Chithandizo choyenera cha wodwala aliyense chimatha kusankhidwa ndi dokotala wodziwa zambiri.

Chithandizo chothandiza pa matenda ngati awa:

Kukhazikitsidwa kwa insulini kusintha matendawa. Jekeseni ndikofunikira makamaka pakukonza pancreatic ntchito.
Odwala amapatsidwa.
Phwando limasankhidwa.
Nthawi zina, chithandizo cha opaleshoni chimasonyezedwa ndikuchotsa minyewa yambiri m'magazi a adrenal ndikupanga kuchepetsa ma hormone.
Kuletsa kwakanthawi kwa mankhwalawa omwe amayambitsa kusokonezeka kwa metabolic m'thupi. Komabe, zimachitika kawirikawiri kuti sizingatheke kusiya mankhwala ena - makamaka, pambuyo pothana ndi impso kapena pochiza mphumu. Zikatero, kuyang'anira kwachipatala kumachitika.

Jakisoni wa insulini amaperekedwa ngati makonzedwe a mankhwala omwe amachepetsa shuga sapereka zotsatira zoyenera za hypoglycemic. Wodwala ayenera kukumbukira kuti chithandizo cha insulin ndi chimodzi mwazinthu zomwe zingapangitse matenda a shuga. Cholinga chofunikira kwambiri chomwe chimatsatiridwa ndi chithandizo cha matenda osokoneza bongo ndichakuti tikwaniritse chipepeso ndi kuchedwetsa zovuta za matendawo.

Kuchotsa kwa gawo limodzi la gren ya adrenal kumachitika kwambiri, chifukwa chithandizo chotere chimawopseza odwala omwe ali ndi zovuta zambiri.

Udindo wa chakudya chamafuta ochepa

Njira zabwino zothanirana ndi glucose wamagazi mumtundu 1 kapena shuga ya 2 ndikuyamba. Nthawi yomweyo, zakudya zimachepetsa chakudya chamafuta - mpaka 20-30 magalamu patsiku. Izi zimawonjezera kuchuluka kwa mapuloteni, komanso mafuta azamasamba.

Ubwino wakudya yamtengo wotsika pang'ono:

amachepetsa kufunika kwa thupi kwa insulin ndi mankhwala ochepetsa shuga,
amakulolani kuti muzikhala ndi shuga nthawi zonse, ngakhale mutatha kudya,
Kukhala bwino kwamunthu kumachita bwino ndipo zizindikiro zonse za matenda ashuga zimatha,
mwayi wopanga zovuta umachepetsedwa,
amachepetsa mafuta m'thupi.

Matenda a Steroid (a sekondale omwe amadalira insulin) amawonekera chifukwa chazindikira kuchuluka kwa ma corticosteroids m'magazi, omwe amakhalapobe kwanthawi yayitali.

Nthawi zambiri, imayamba chifukwa cha kuoneka kwa zovuta zazikulu za matenda omwe amapangitsa kuti mahomoni apangidwe mofulumira.

Komabe, komabe, nthawi zambiri zimawonekera pambuyo povomerezeka kwa nthawi yayitali ndimankhwala a mahomoni. Ndiye chifukwa chake kudwala kumeneku kumatchedwanso mtundu wa shuga.

Matenda a shuga a Steroid kuchokera komwe adachokera sakhala m'gulu la matenda achamba. Ndikofunikira kudziwa kuti poyamba sizimagwirizanitsidwa ndi mitundu yayikulu yamatenda a kapamba.

Anthu omwe alibe vuto la metabolism wamafuta, vuto la kuchuluka kwa mahomoni a steroid, amatha kupeza matenda ofatsa, omwe amachoka pomwe atatha. Chofunikira ndichakuti pafupifupi theka la odwala onse omwe akudwala matendawa amalandila fomu yodziyimira payokha kupita ku matenda omwe amadalira insulin.

Glucocorticosteroids (Dexamethasone, Prednisolone, Hydrocortisone) amagwiritsidwa ntchito ngati mankhwala othandiza komanso odana ndi kutupa pazovuta zotere:

Mphumu ya bronchial,
nyamakazi
kuphwanya magwiridwe antchito a chitetezo cha thupi,
multiple sclerosis.

Steroid shuga mellitus imatha kuchitika chifukwa chogwiritsa ntchito mankhwala kwa nthawi yayitali monga kulera pakamwa ndi thiazide diuretics.

Mlingo wamphamvu kwambiri wa corticosteroids ungagwiritsidwe ntchito pochiza, womwe umalimbana ndikuchotsa kutupa pambuyo pa opaleshoni, pomwe unamuyika impso.

Pambuyo pakuchita opaleshoni yayikuluyi, odwala ayenera kumwa mankhwala oyenera pamoyo wawo wonse kuti apondereze chitetezo cha thupi. Amakhala ndi chizolowezi chotupa chomwe chimatha kukhudza ziwalo zopatsirana moyenera.

Zizindikiro za matenda omwe adayamba chifukwa cha chithandizo cha mankhwala chomwe chimatenga nthawi yayitali amadziwitsa kuti odwala amadziwika kuti ndi anthu osatetezeka kwambiri.

Kuti athetse koyamba matenda ashuga, anthu onenepa kwambiri ayenera kudzisamalira ndikuyamba kutaya mapaundi owonjezera.

Koma omwe ali ndi kulemera kwabwino, muyenera kuyamba kusewera masewera ndikusintha pang'ono zakudya zawo za tsiku ndi tsiku, kuwonjezera kuwonjezera zitsamba, masamba ndi zipatso zina.

Ngati munthu akudziwa zam'tsogolo za matendawa, sayenera kuyamba kumwa mankhwala a mahomoni.

Matendawa ndi osiyana chifukwa amakhala ndi zizindikiro za matenda ashuga amtundu woyamba komanso wachiwiri.

Matendawa amayamba chifukwa chakuti kuchuluka kwa corticosteroids kumayamba kuwononga maselo a beta a kapamba.

Amapitilizabe kupanga ma pancreatic mahomoni omwe amayendetsa kagayidwe kazakudya kwa nthawi yayitali.

Pakapita kanthawi, kuchuluka kwa mahomoni omwe amapangidwa amachepetsa kwambiri ndipo khungu lake limasokonekera. Izi ndi mtundu wa matenda ashuga a 2. Pambuyo pake, maselo angapo a beta amawonongeka kwathunthu, zomwe zimapangitsa kuti ayime pakupanga insulin. Poterepa, matendawo amayamba kupitilirabe ngati matenda a shuga a mtundu woyamba.

Zizindikiro za matenda a shuga a Steroid ali ndi izi:

kuchuluka kukodza
ludzu lalikulu
kutopa.

Monga lamulo, chizindikiro cha matenda a shuga a steroid ndi chofatsa, kotero odwala samapereka chidwi chokwanira kwa iwo.

Amayamba kuchepa thupi msanga, ngati matenda amtundu 1. Kuyesedwa kwa magazi sikamathandiza kuzindikira matendawa nthawi yake.

Komabe, kawirikawiri kuchuluka kwa glucose kumatha kukhala okwera kwambiri. Kuphatikiza apo, kuchuluka kwa propanone mu mkodzo kumakhalabe kosangalatsa.

Mtundu wa shuga ungawonekere kwa odwala onse. Koma ngati munthu akumwa mankhwala a mahomoni nthawi zonse, ndiye kuti chiopsezo chotenga matenda ndi iye chikukula kwambiri.

The pathogenesis yokhala ndi matenda a shuga

Njira yolimbikitsira shuga-6-phosphatase m'chiwindi ndi mahomoni amtunduwu amathandizira kutulutsa kwa glucose kuchokera ku chiwalochi. Mwa zina, glucocorticoids amachepetsa kwambiri ntchito ya hexokinase, yomwe imachepetsa kuyamwa kwa glucose.

Polankhula za matenda a shuga a steroid, kuphatikiza kwa matendawa ndikuti kutseguka kwa mapuloteni kungayambitse kukula kwake, chifukwa chomwe mafuta ochulukirapo m'magazi amapangidwa. Chifukwa cha izi, kuchuluka kwa shuga m'magazi kumawonjezeka.

Mwanjira ina, matenda a shuga a steroid ndi mtundu wa matenda omwe amatenga matendawa, omwe amayamba chifukwa cha kuchuluka kwa mahomoni a adrenal m'magazi. Izi zimagwiranso ntchito pa mankhwalawa omwe ali ndi zinthu zomwe zimapangidwa.

Zingachitike kuti insulini italeka kupangidwa mthupi, matendawa amapitilira chimodzimodzi monga matenda ashuga amtundu woyamba. Koma ndi zonsezi, ili ndi zizindikiro za matenda ashuga a 2.

Kuchiza mwachindunji kumatengera mtundu wanji wakuphwanya wodwalayo. Kwa anthu omwe ali onenepa kwambiri, koma amapanga insulin, zakudya zapadera ndi mankhwala omwe shuga yotsika ndiyabwino. Izi zikuphatikiza Glucofage ndi Thiazolidinedione. Mlingo wocheperako wa insulin nthawi zina amalamula.

Pankhani yamavuto apachiwopsezo, kuyambitsa kwa insulin kumapangitsa kuti ichite ntchito ndi katundu wochepa. Izi ndizotheka ngati maselo a beta akupitilizabe ntchito yawo. Zakudya zapadera zimatha kuthandiza mankhwalawo, kuthetseratu kugwiritsa ntchito mankhwala okhala ndi chakudya.

Kwa anthu omwe ali ndi chakudya chamagulu okwanira, chakudya No. 9 chitha kugwiritsidwa ntchito, ndipo kwa odwala okulirapo, zakudya No. 8 zingagwiritsidwe ntchito.

Ngati munthu akuvutika ndi matenda a shuga a steroid, kapamba sathanso kudzipangira payekha payokha, ndiye kuti amamulembera momwe amapangira jakisoni wovomerezeka.

Pankhaniyi, munthu sayenera kuyiwala za kuwunika kosalekeza kwamisempha yamagazi. Njira yakuchiritsira ikuyenera kuchitika momwemo ndi mtundu 1 wa matenda ashuga. Kuphatikiza apo, ndi mtundu uwu wa matendawa pomwe ndikosatheka kubwezeretsa maselo a beta omwe adafa kale.

Matenda amtunduwu amapezeka kuti kuchuluka kwa shuga m'magazi kumayamba kupitirira chizindikiro cha 11.5 mmol mutatha kudya, ndipo kutsogolo kwake kuli zoposa 6 mmol. Pambuyo pozindikira zowopsa, ndikofunikira kulumikizana ndi dokotala kuti akuthandizeni.

Poyamba, katswiri ayenera kupatula kwathunthu matenda onse omwe ali mgululi. Njira yochizira matendawa imatha kukhala yamwambo komanso kukhala ndi mayendedwe ofunikira. Zotsirizirazi ndizothandiza kwambiri, koma zimafunanso maluso ena odziletsa kwa wodwalayo.

Njira zachikhalidwe zachikhalidwe zimachokera pamfundo yomwe ili yofanana ndi miyeso yofananira yachiwiri.

Ngati kapamba amavulala, ndiye kuti mlingo wa insulin ndi womwe umapangidwa. Mankhwala, hypoglycemic ndi mahomoni othandizira amagwiritsidwa ntchito, mwachitsanzo, Glucofage.

Ngati wodwalayo ali ndi mtundu wocheperako wa matenda, ndiye kuti sulfonylureas angagwiritsidwe ntchito, zomwe zingathandize kuthana ndi vutoli. Koma njirayi ili ndi zotsatira zoyipa, zowopsa kwambiri komanso zosayembekezeka zomwe zimachitika ndikubadwa kwa myocardial infarction.

Izi ndichifukwa choti chakudya cha carbohydrate chimachepa kwambiri, chifukwa chomwe pamakhala kuphwanya kowopsa pakuchita kwa ziwalo ndi machitidwe. Ndi chifukwa ichi kuti matendawa amatha kusintha pang'onopang'ono kukhala mawonekedwe otchedwa insulin.

Mwazinthu zina zapadera, yankho lolondola kwambiri ndikuchita opareshoni. Matani osafunikira amachotsedwa ku adrenal gland ngati hyperplasia yapezeka.

Pambuyo pakuchita opaleshoni, mkhalidwe wa wodwalayo umayamba bwino, ndipo akuchira. Komabe, ndikofunikira kutsatira malangizo a adotolo kuti matendawo azikhala okhazikika.

Pangozi ndi anthu omwe ali ndi mafuta ochulukirapo. Kuti mupewe kupatula matendawa omwe mungakhale nawo, muyenera kuyang'anitsitsa zakudya zanu.

Kodi matenda a shuga a steroid amathandizidwa bwanji?

Matenda a shuga a Steroid amatha kuthandizidwa chimodzimodzi monga matenda omwe amadalira insulin. Mukamapereka mankhwala, ndikofunikira kuganizira za matenda onse omwe wodwala ali nawo. Izi zikusonyeza kuti chithandizo chitha kuperekedwa ndi dokotala. Mwa njira zochizira matenda a shuga a steroid, tati:

Onetsetsani kuti mukugwiritsa ntchito pulogalamu yochepetsera ya carb.

Mankhwala ochepetsa shuga amagwiritsidwa ntchito.

Nthawi zina, kulowererapo kwa opaleshoni ndikofunikira kuti muchepetse minyewa yambiri kuchokera ku adrenal cortex, yomwe imakulolani kuti muchepetse kaphatikizidwe ka mahomoni a gulu la corticosteroid.

Patulani mankhwala onse omwe angayambitse matenda a metabolic. Ngakhale izi sizingatheke nthawi zonse, mwachitsanzo, ndi mphumu. Zikatero, kuyang'anitsitsa boma la kapamba ndikofunikira.

Tiyenera kudziwa kuti jakisoni wa insulini amatchulidwa pokhapokha ngati mankhwala ochepetsa shuga sangabweretse zotsatira zomwe akuyembekezeka. Wodwala ayenera kukumbukira kuti insulini makonzedwe ndi njira imodzi yokha yochepetsera kuchuluka kwa shuga m'magazi.Cholinga choyambirira cha mankhwala a shuga a shuga ndi kubwezeretsa ndi kuchedwetsa zovuta zilizonse zomwe zingachitike. Matenda a shuga pankhaniyi ndi matenda oopsa kwambiri ndipo amatha kusokoneza ntchito ya pafupifupi dongosolo lililonse la thupi. Kuchotsa opaleshoni ya minofu ya adrenal cortex ndiye muyeso woopsa kwambiri, chifukwa ungayambitse kuvulaza kwambiri thanzi la munthu.

Kodi ndichifukwa chiyani zakudya zama carb ochepa ndizofunikira mu shuga?

Kuti muthane ndi kuchuluka kwa shuga m'magazi, kwa mtundu uliwonse wa matenda ashuga, ndikofunikira kusintha kugwiritsa ntchito pulogalamu ya zakudya zopatsa mphamvu. Mlingo watsiku ndi tsiku wa michereyi sayenera kupitirira 30 g. Ndikofunikanso kuganizira kuchuluka kwa mapuloteni komanso mafuta azamasamba azakudya. Tiyeni tiwone zabwino zazikulu zaakudya chamafuta ochepa a shuga:

Ngakhale chakudya chikatha, kuchuluka kwa glucose kumakhala kosavuta kukhala kosavuta panthawi yochepa.

Amamva bwino, ndipo zizindikiro za matendawa zimaponderezedwa.

Chiwopsezo cha zovuta zimachepetsedwa.

Mulingo woyenera wa lipoprotein wopanga ndi wofanana.

Kodi matenda a shuga a steroid angalepheretsedwe bwanji?

Njira imodzi yothanirana ndi matendawa ndikugwiritsa ntchito pulogalamu yathanzi ya carb wotsika. Izi zikugwira ntchito kwa onse omwe ali ndi matenda ashuga komanso omwe ali pachiwopsezo. Ngati mwakhala mukugwiritsa ntchito mankhwala a mahomoni, ndiye kuti muyenera kuganizira zamasamba olimbitsa thupi. Kupanda kutero, kuwonjezeka kwa kulemera kwa thupi ndikotheka, komwe nthawi zambiri kumakhala kukula kwa matendawo.

Ngati mumangokhala wopanda mphamvu ndipo ntchito yanu yatsika kwambiri, muyenera kufunsa dokotala. Matenda a shuga a Insulin samachiritsidwa konse. Mwanjira ina, izi zimagwiranso ntchito kwa matenda ashuga akale. Muyenera kukumbukira. Chofunika ndikusayamba matendawa, chifukwa chifukwa ichi chizikhala chovuta kwambiri kulimbana nacho. Dziwani kuti maphunziro angapo adawonetsa maubwino omanga thupi. Kuphatikiza apo, pamene wosewera amatenga nawo mbali kwambiri, pamakhala chiopsezo chotenga matendawa.

Kodi pali chibadwa chomwe chimayambitsa matenda ashuga?

Masiku ano, nthawi zambiri amakambirana za genetics komanso kudziwiratu kwa china chake. Zachidziwikire mudakumana ndi zolemba patsamba lanu zatsamba Zachidziwikire, chidziwitso chobadwa nacho chitha kukhala chofunikira pa matenda. Ngati titalankhula za ubale pakati pa majini ndi matenda ashuga, ndiye kuti zilipo.

Ngati timalankhula za matenda amtundu 1, ndiye kuti muyenera kufunsa dokotala ngati muli ndi abale omwe ali ndi vutoli. Asayansi akutsimikiza kuti kutengera kwa chibadwa cha matendawa ndizofunikira kwenikweni kwa anthu aku Europe. Kafukufuku wasonyeza kuti khansa yambiri ya pakhungu yomwe ilipo pakhungu, imachepetsa mwayi wokhala ndi matenda ashuga.

Pankhani ya matenda a shuga a 2, munthu amayenera kuyesedwa pazinthu zotsatirazi:

Kukhalapo kwa kunenepa kwambiri komanso kunenepa kwambiri.
Atherosclerosis motsutsana maziko a kwambiri matenda oopsa.
Kukhalapo kwa gynecological pathologies mwa akazi, mwachitsanzo, ovary ya polycystic.
Kukhalapo kwa zochitika zosautsa mtima zonse.
Zochita zolimbitsa thupi.
Zaka zopitilira zaka 40 motsutsana ndi chilichonse chomwe chatchulidwa pamwambapa.

Dziwani zambiri za matenda a shuga a steroid mu kanema pansipa:

Kodi ma steroid amakhudza bwanji shuga?

Ma steroids angayambitse kuchuluka kwa shuga m'magazi, ndikupangitsa chiwindi kuti chisagane ndi insulin yomwe ikupezeka m'matumbo.

Mwazi wa m'magazi ukakhala wambiri, insulin imatulutsidwa ku kapamba ndipo imaperekedwa kwa chiwindi.

Insulini ikaperekedwa kwa chiwindi, imayimira kuchepa kwa shuga omwe nthawi zambiri amaperekedwa m'maselo a mafuta. M'malo mwake, shuga amatengedwa kuchokera m'magazi kupita ku maselo. Izi zimachepetsa kuchuluka kwa shuga m'magazi.

Ma steroids amatha kupangitsa chiwindi kuti chisavutike kwambiri ndi insulin. Amatha kupangitsa kuti chiwindi chizipitilira kutulutsa shuga, ngakhale ngati kapamba atulutsa insulin, ndikuti aime.

Ngati izi zikupitirirabe, zimayambitsa kukana kwa insulini pamene maselo amasiya kuyankha insulin yopangidwa ndi thupi. Matendawa amatchedwa shuga.

Matenda a shuga ndi omwe amachititsa kuti shuga wa magazi a munthu akhale wolemera kwambiri. Pali mitundu iwiri yayikulu ya matenda a shuga:

Mtundu woyamba wa shuga: momwe kapamba samatulutsa insulini.
Mtundu wa shuga wachiwiri: momwe zikondamoyo sizipanga insulin yokwanira, kapena maselo amthupi samayankha insulin.

Matenda a shuga omwe amapangidwa ndi steroid ndi ofanana ndi matenda amtundu wa 2, chifukwa ma cell a thupi samayankha insulin. Komabe, shuga ya steroid imazimiririka chithandizo cha mankhwala a steroid chikamalizidwa. Ndipo mtundu 2 wa matenda ashuga ndi matenda amtundu woyamba 1 ndi matenda omwe ayenera kuthana nawo moyo wonse.

Zizindikiro za matenda a shuga a Steroid

Zizindikiro za matenda am'mimba a shuga omwe amachititsa kuti munthu akhale ndi shuga komanso chimodzimodzi. Mulinso:

kamwa yowuma
ludzu
kutopa
kuwonda
kukodza pafupipafupi
masomphenya osalala
kusanza ndi kusanza
Khungu lowuma
kulumikizika kapena kutayika kwa mikono kapena miyendo

Anthu ena atha kukhala ndi shuga wambiri popanda chisonyezo. Ichi ndichifukwa chake ndikofunikira kuti anthu aziyang'anira kawirikawiri shuga m'magazi awo atatha kumwa ma steroids.

Kodi anthu odwala matenda a shuga amathandizira bwanji?

Monga mitundu yonse ya matenda ashuga, kusintha kwa moyo ndikofunikira ndi matenda ashuga chifukwa cha ma steroids kuti pakhale kusintha kwamphamvu kwa shuga m'magazi. Kusintha kumeneku kungaphatikizepo chakudya chamagulu komanso kuchita masewera olimbitsa thupi pafupipafupi.

Kuwonjezeka kwa shuga m'magazi kumachitika kawirikawiri mkati mwa masiku 1-2 atayamba ma steroids. Ngati ma steroid amatengedwa m'mawa, kuchuluka kwa shuga m'magazi nthawi zambiri kumatsika masana kapena madzulo.

Anthu omwe amamwa ma steroid amayenera kuwunika shuga wawo wamagazi pafupipafupi. Angafunike kumwa mankhwala am'kamwa kapena jakisoni wa insulini ngati shuga wawo ali wokwera.

Monga lamulo, misempha ya shuga ya magazi iyenera kubwerera pamlingo wawo wammbuyo mkati mwa masiku 1-2 mutatha kusiya kugwiritsa ntchito ma steroid. Komabe, anthu ena amatha kukhala ndi matenda a shuga a 2, ndipo wodwalayo adzafunika kuthandizidwa ndi mankhwalawa pogwiritsa ntchito mankhwala amkamwa kapena insulin.

Gulu lamavuto

Chiwopsezo chokhala ndi matenda amtundu wa 2 kuchokera ku matenda a shuga a steroid chimawonjezeka ndi Mlingo wowonjezera wa mankhwala a steroid, atapatsidwa kutalika kwa nthawi. Zina zomwe zimayambitsa matenda a shuga 2 ndi monga:

zaka 45 kapena kupitirira
onenepa kwambiri
mbiri ya banja la matenda ashuga a 2
matenda ashuga
kulolerana kwa shuga

Matenda a shuga a Steroid ndi mtundu wachiwiri wa matenda a shuga 1 omwe amadalira insulin. Kukula kwake kumachitika chifukwa chowonjezera corticosteroids m'magazi a odwala omwe amapangidwa ndi adrenal cortex, kapena atatha kumwa mankhwalawa. Amalandira chithandizo cha matenda angapo ndikupereka mwayi wochepetsera kupweteka kwambiri. Chiphunzitsochi sichimagwirizanitsidwa ndi kusokonezeka kwa β-cell of islets a Langerhans a kapamba.

Maziko a chitukuko cha matendawa

Matenda osokoneza bongo amayamba motsogozedwa ndi zinthu zingapo. Izi zikuphatikiza:

Mankhwala osokoneza bongo ochulukirapo a glucocorticoid, omwe amachititsa kuti azindikire shuga wambiri wodwala wa sodium omwe saulula kuphwanya kagayidwe kazakudya.
Kusintha kwa shuga wosadalira insulini kupita ku mawonekedwe ake omwe amadalira insulin.
Kusavomerezeka mu mahomoni kumbuyo chifukwa cha kuphwanya kwa ntchito kwa hypothalamus ndi gitu planditary ndikuchepetsa kukana kwa maselo ndi minofu yake ku insulin.
Dziwitsani matenda oopsa, omwe amawonetsa chithokomiro chamthupi komanso amachepetsa kukonza kwa monosaccharide ndi zimakhala mthupi la wodwalayo.
Kuzindikiritsa kusakhazikika pakati pamahomoni, chomwe chimakhala chifukwa chosagwirizana ndi zomwe thupi limapanga.
Kunenepa kwambiri kwa wodwala, komanso kuchuluka kwa hydrocortisone m'thupi - mahomoni opangidwa ndi adrenal cortex.

Njira yofatsa yamatenda, yomwe kukula kwake kumalumikizana ndi mankhwala osokoneza bongo a glucocorticoids, imatha kutha yokha itatha kumwa. Zinthu ngati izi zimapangitsa kuti pakhale tsogolo labwino la matenda a shuga a steroid, omwe amapezeka chifukwa cha kupatuka kwa mulingo wa monosaccharide m'magazi.

Kusamalira panthawi yake matendawa kumathetsa chiopsezo cha zovuta zomwe zimasokoneza thanzi komanso moyo wa wodwalayo.

Mankhwala ogwiritsa ntchito glucocorticoid wogwiritsidwa ntchito mopitirira muyeso, omwe amachititsa kuti shuga azikhala ndi matenda osokoneza bongo, amakhala ndi anti-kutupa. Amalembedwa kuti athetse mavuto a nyamakazi, mphumu ya bronchial, angapo a autoimmune pathologies. Kuphatikiza pa glucocorticoids, matenda a shuga a steroid amatha chifukwa cha kugwiritsidwa ntchito kwa ma diuretics mu mawonekedwe a Nefriks, Navidrex, Hypothiazide, Dichlothiazide ndi mitundu yina ya mapiritsi oteteza kubereka kwa mahomoni.

Kuwonetsedwa kwa matendawa

Matenda a shuga a Steroid amaphatikiza zizindikiro za matenda amtundu 1 komanso matenda ashuga 2. Izi zikuphatikiza:

Maonekedwe a ludzu ndi kuyabwa kwa zinthu pamtunda wa khungu.
Pafupipafupi kukodza.
Kuphwanya kakhalidwe, kuchepa kwamphamvu yolimbitsa thupi, kuchititsa kutopa kwambiri, kutopa kwa wodwala.
Osowerengeka milandu kupeza kwambiri shuga, acetone m'magazi ndi mkodzo.
Kuchepetsa thupi.

Zizindikiro zazikulu za pathology sizosiyana mu chithunzi chotchulidwa. Amatuluka chifukwa cha kuwonongeka kwa ma β-maselo a ma islets a Langerhans a kapamba ndi kuchuluka kwa corticosteroids. Mavuto a insulini m'thupi la wodwalayo amachepa, ndipo khungu lake limachepa. Zotsatira zake, chifukwa cha kuwonongeka kwa maselo a β-cell, kupanga kwa mahomoni a protein omwe amapangidwa ndi kapamba amayimitsidwa. Kukula kwa matendawa sikusiyana ndi mtundu wa matenda ashuga amtundu wa 1 ndipo kumawonetsa Zizindikiro zomwe zimayamba ndi matendawa.

Njira zothandiza kuti athetse matenda

Chithandizo chovuta kwambiri cha matenda a shuga amellitus ndi ofanana kwambiri ndi njira yothetsera vuto la matenda osagwirizana ndi insulin. Amasanjidwa payekhapayekha, mogwirizana ndi mawonekedwe a thupi la wodwalayo, zizindikiro za mulingo wa monosaccharide m'magazi ake. Matenda a Steroid amathandizidwa popanda zovuta zambiri. Kutsatira okhwima palingaliro, upangiri wa endocrinologist ndiye njira yofunikira yopezera zotsatira zabwino. Chithandizocho chimaphatikizaponso njira zina zochizira. Izi zikuphatikiza:

Kuti mupewe zovuta zomwe zingakhale zowopsa pamoyo komanso thanzi la wodwalayo, ndikofunikira kuzindikira matendawa munthawi ndikuyamba chithandizo moyang'aniridwa ndi dokotala!

Gulu la zakudya zoyenera malinga ndi zakudya zamafuta ochepa.
Kumwa mankhwala ochepetsa shuga.
Kukhazikitsa insulin mankhwala popanda kuyembekezera hypoglycemic zotsatira kumwa mapiritsi zotchulidwa kuti shuga shuga.
Kudzudzula kwambiri.
Kuthana ndi mankhwala opangidwa ndi corticosteroid omwe adayambitsa kukula kwa matenda.

Opaleshoni nthawi zina imatha kutumizidwa kuti ichotse minyewa yambiri m'magazi a adrenal ndikuchepetsa kupanga kwawo kwa corticosteroids.

Chithandizo cha matendawa chili ndi zolinga zingapo. Pambuyo kukhazikitsa, ndikotheka kusintha mulingo wa monosaccharide, ndikuchotsanso zomwe zimapangitsa kuwonjezeka kwa kuchuluka kwa mahomoni opangidwa ndi adrenal cortex. Izi zimawonjezera mwayi wobwezeretsa ntchito za β-maselo a timakhanda tachilumba cha Langerhans cha kapamba, yemwe amayang'anira kupanga insulin. Kutsatira malangizo a dokotala pazakudya zokhala ndi carb ochepa, moyo wokangalika, kusiya zizolowezi zoipa kumapereka mwayi wopeza zotsimikizika komanso kupatula kukula kwa zovuta za matenda ashuga.

Khulupirirani madokotala ndipo khalani athanzi!

Woyambitsa matenda ashuga ali ndi mwayi uliwonse wosokonezeka pamankhwala olemba komanso mayeso omwe adokotala amapanga akakhazikitsa matenda oyamba a matenda ashuga.

Mukubwereza kwa lero, tidzakambirana za chithokomiro cha chithokomiro komanso kufunikira kwake ndikuwonetsa kuzindikira koyenera komanso kolondola kokhudzana ndi chithokomiro cha chithokomiro. Chimodzi mwazinthu zofunikira kwambiri zomwe tikambirane kusanthula kwa mahomoni .

Zomwe zimayambitsa matenda a chithokomiro kulephera nthawi zambiri zimakhala zofanana kwambiri ndizomwe zimayambitsa matenda a shuga 1. Izi zikufotokozedwa ndikudutsa kuyezetsa magazi ndi kuyesa kwamwazi m'magazi ndipo zimawonetsedwa mwa kuchuluka kwa maselo oyera m'magawo ake.

Ngati, mutatha kuyesa magazi ambiri, zotsatira pamwambapa zimapezeka, ndiye tengani mayeso a mahomoni . Ndikofunikira kudziwa kuti kukhazikitsa kuzindikira koyenera sikokwanira thyrotropic hormone assay - dzina lina ndi thyrotropin, TSH .
Ndikofunikira kufufuza, kudutsa kusanthula kwa mahomoni T3 yaulere komanso T4 yaulere .

Ndizofunikanso kudziwa kuti kusowa kwa mahomoni a chithokomiro kungayambitse kuchuluka kwa cholesterol "yoyipa", homocysteine ndi lipoprotein. Izi ndizofunikira makamaka kwa odwala matenda ashuga.

Pakachitika kuti musankhe tengani mayeso a mahomoni nokha ndipo zotsatira zake zinali zopanda pake, muyenera kulumikizana ndi endocrinologist. Nthawi zambiri, pakalandira chithandizo chamankhwala ndi dokotala, kuchuluka kwa mahomoni amabwerera mwakale. Koma izi sizitanthauza kuti tsopano mutha kumasuka ndikuyiwala za chilichonse. Ndikofunikira kutenga mayeso a mahomoni kamodzi pamwezi uliwonse wa 4, kuti mutha kudziwa momwe mankhwalawa amathandizira komanso kukhazikika kwa zotsatirazi.

M'tsogolo mayeso a mahomoni Mutha kumwa miyezi isanu ndi umodzi iliyonse.

Steroid shuga mellitus ndimatenda omwe amayamba chifukwa chakutha kugwira bwino ntchito kwa adrenal cortex kapena kugwiritsa ntchito mankhwala osokoneza bongo kwa nthawi yayitali.

Choopsa chachikulu cha matenda a shuga a steroid ndi cha anthu omwe ali ndi chiyembekezo chokhala ndi matenda ashuga, tidzazindikira chomwe chimakhala, kaya ndi hypercorticism yolumikizidwa ndi izi, komanso zoyenera kuchita.

Matendawa amasokoneza kapamba, amawononga maselo amthupi ndikusokoneza kupanga kwachilengedwe kwa insulin. Pachifukwa ichi, shuga ya matenda a shuga imatchedwa sekondale yodalira matenda a shuga.

Pali zifukwa ziwiri zazikuluzikulu zomwe zimapangidwira shuga ya steroid:

Monga zovuta za matenda omwe amapangitsa kuchuluka kwama mahomoni a adrenal cortex, mwachitsanzo, matenda a Itsenko-Cushing,

Zotsatira zake zakukhazikika kwa mankhwala okhala ndi mahomoni.

Nthawi zambiri, chomwe chimayambitsa matenda a shuga a steroid ndi kugwiritsa ntchito mankhwala a mahomoni, chifukwa chake nthawi zina amatchedwa matenda osokoneza bongo. Matenda owopsa nthawi zambiri amakula limodzi ndi vuto lalitali ndi mankhwala a glucocorticoid monga:

Mankhwalawa nthawi zambiri amawagwiritsa ntchito kuti athane ndi matenda otupa komanso matenda othandizira odwala matenda amitsempha. Chifukwa chake, matenda a shuga a steroid nthawi zambiri amakhudza odwala omwe ali ndi matenda otsatirawa:

Mphumu ya bronchial,
Rheumatoid nyamakazi,
Matenda osiyanasiyana a autoimmune (pemphigus, eczema, lupus erythematosus),
Multiple sclerosis.

Kuphatikiza apo, kugwiritsidwa ntchito kwa ma diuretics ena kungakhudze kukula kwa matenda a shuga a steroid. Odziwika kwambiri pakati pawo ndi zida zotsatirazi:

Komanso, mtundu uwu wa shuga umapezeka kawirikawiri mwa amayi omwe agwiritsa ntchito njira zakulera za mahomoni kwa nthawi yayitali kuti ateteze pathupi osafunikira.

Kuphatikiza apo, anthu omwe anachitapo opaleshoni yopatsirana impso amakhalanso pachiwopsezo.

Kuti mudziwe momwe ma steroid ndi matenda a shuga amagwirizanirana, muyenera kumvetsetsa momwe mankhwala a mahomoni amachitikira m'thupi la munthu. Ndi kudya kwa nthawi yayitali ndalamazi, magazi a wodwalayo amasintha modabwitsa. Potere, mulingo wa corticosteroids mmenemo umachuluka kwambiri.

Ma sodiumids amakhudza maselo apachifungo, omwe amatsogolera pang'onopang'ono. Izi zimakhudza kuchuluka kwa insulini ya mahomoni m'thupi la wodwalayo, ndikuchepetsa pang'ono ndikuyambitsa kukula kwa matenda a shuga. Kuphatikiza apo, mahomoni a steroid amapangitsa kuti maselo amthupi asagwiritsidwe ntchito ndi insulin, zomwe zimasokoneza kagayidwe kazakudwala.

Chifukwa chake, zizindikiro za matenda a shuga a mitundu 1 ndi mtundu 2 amadziwika ndi matenda a shuga. Zotsatira zake, njira ya matendawa imatha kukhala yovuta kwambiri ndipo imabweretsa zovuta zazikulu.

Dziwani kuti matenda ashuga, omwe amayambitsidwa ndi ma steroid, amakula pang'onopang'ono ndipo matendawa akangoyamba matendawa sangathe kudziwonetsa. Zizindikiro zotsatirazi zikuwonetsa kupezeka kwa munthu wodwala matenda a shuga:

Ludzu lalikulu. Kuti muchepetse wodwala wake amamwa madzi ambiri,
Kutopa ndi kuchepa kwa magwiridwe antchito. Zimakhala zovuta kuti munthu achite zinthu wamba,
Kukodza pafupipafupi. Mukamayendera chimbudzi aliyense amadwala mkodzo,

Kuphatikiza apo, mosiyana ndi mtundu 1 ndi mtundu wa 2 wodwala matenda am'mimba, odwala omwe ali ndi mtundu wa matenda a steroid, kuchuluka kwa shuga m'magazi ndi mkodzo sikwaposa momwe zimakhalira. Zomwezo zimagwiranso ntchito pamlingo wa acetone, zomwe nthawi zambiri sizipitilira zovomerezeka. Izi zimasokoneza kwambiri kuzindikira matendawa.

Zomwe zimathandizira pakupanga matenda a shuga a steroid:

Njira yayitali ya chithandizo ndi corticosteroids,
Kukhazikika kwa mankhwala a mahomoni muyezo waukulu,
Kuchulukana pafupipafupi kwa shuga wamagazi pazifukwa zosadziwika,

Ndikofunika kutsindika kuti odwala ambiri omwe amamwa mankhwala a mahomoni amatha kukhala ndi matenda ashuga. Komabe, nthawi zambiri imayamba yokhala yofatsa ndipo imazimiririka ikamaliza maphunziro.

Mtundu wowopsa wa matendawa, monga ulamuliro, umawonedwa mwa anthu omwe ali ndi matenda ashuga kapena kale omwe ali ndi matenda. Anthu ambiri omwe ali ndi matenda ashuga samadziwa za matenda awo, popeza matendawa amapitilira m'njira yatsopano. Komabe, kutenga corticosteroids kumathandizira njira ya matendawa ndikuthandizira kukula.

Chinthu chinanso chomwe chikuthandizira kuti matenda a shuga a steroid ayambe kwambiri ndi onenepa, zomwe zimatsimikizira kuti zimalumikizana.

Anthu omwe ali ndi vuto la kunenepa kwambiri ayenera kumwa mankhwala a mahomoni mosamala kwambiri pokhapokha ngati dokotala akuwalimbikitsa.

Chithandizo cha matenda a shuga a steroid ziyenera kuchitika molingana ndi gawo la matendawa. Ngati chinsinsi cha insulini m'thupi chitathetsedwa, ndiye kuti kulimbana ndi matendawa kuyenera kuchitika chimodzimodzi ndi mtundu wa matenda ashuga 1.

Chithandizo cha matenda a shuga a insulin amadalira njira zotsatirazi:

Jakisoni wa insulin wa tsiku ndi tsiku
Kutsatira zakudya zochiritsika (ichi chingakhale chakudya chochepa kwambiri, koma chimalingana ndi anthu omwe ali ndi matenda a impso),
Zochita zolimbitsa thupi (kuyenda, kuthamanga, masewera olimbitsa thupi),

Kuphatikiza apo, kudya komanso kuchita masewera olimbitsa thupi ndizofunikira kwambiri kukonza mkhalidwe wa wodwalayo. Mankhwalawa amathandiza kukhala ndi shuga wabwinobwino.

Ndikofunikira kutsimikizira kuti shuga yodalira insulini ndi matenda osachiritsika, chifukwa ma cell a pancreatic b omwe anawonongedwa ndi corticosteroids sakubwezeretsedwanso.

Ngati kupanga kwa insulini sikunasokonezeke kwathunthu ndipo maselo a gland akupitiliza kupanga mahomoni, ndiye kuti wodwalayo amapanga shuga wosadalira insulini, womwe umafanana ndi matenda a shuga a 2.

Mankhwalawa amafuna:

Zakudya zamoto zochepa
Zochita zolimbitsa thupi
Kumwa mankhwala omwe amachititsa chidwi cha minyewa kupita ku insulin: Glucophage, Thiazolidinedione ndi Siofor,
Kunenepa kwambiri (ngati kuli)
Analoleza jakisoni wa insulin kuti asungitse zofunsirazo.

Ndi matenda amtunduwu a shuga, ntchito ya pancreatic imatha kuchira kwathunthu, zomwe zikutanthauza kuti shuga yosadalira insulini imachiritsidwa.

Matenda a Steroid ndi mtundu waukulu wa shuga womwe umadalira insulin, womwe umatha kuchitika mosasamala ndi zaka (umatha kukula ngakhale mwa ana). Vuto lalikulu ndi kupezeka kwake ndi kusapezeka kwa zizindikiro za pachimake. Zomwe zimayambitsa matendawa nthawi zambiri zimakhala zodetsa nkhawa. Nthawi zina zambiri zomwe zimapezeka mu mahomoni a adrenal m'magazi zimakhala zomwe zimayambitsa matenda. Izi zitha kuchitika chifukwa cha matenda komanso kuthana kwa nthawi yayitali ndi mankhwala a glucocorticoid.

Njira zakulera za pakamwa, diuretics, mankhwala ena amphumo, arthrosis, matenda a Itsenko-Cushing, ndi collagenosis zimayambitsidwa makamaka ndi matenda a shuga a steroid. Popita nthawi, kugwiritsa ntchito mankhwalawa pafupipafupi kumatha kuyambitsa zovuta zamapuloteni ndi zakudya, motero zimapangitsa kuchuluka kwa shuga m'magazi. Zodabwitsazi ndizowopsa kwambiri komanso zoletsa chiwindi kugwira ntchito molingana ndi kuchuluka kwa glycogen.

Chithandizo cha matenda a shuga a steroid

Chithandizo chovuta cha matenda a shuga a steroid umalimbana ndi:

matenda a shuga
Kuchotsa kwa zomwe zidayambitsa kuchuluka kwa mahomoni mu adrenal cortex.

Nthawi zambiri pamakhala zochitika zomwe odwala sangathe kuchita popanda kuchita opaleshoni: mochuluka amachotsa minyewa yambiri m'magazi a adrenal. Kuchita koteroko kumatha kusintha matendawa pawokha, ndipo nthawi zina kumathandizanso shuga kukhala wabwinobwino. Makamaka ngati wodwalayo angatsatire chithandizo chamankhwala ndi zakudya, zomwe zimapangidwira cholesterol yambiri komanso kunenepa kwambiri.

Kulandira mankhwala kumaphatikizapo kumwa mankhwala omwe amachepetsa shuga ya magazi.

Pa gawo loyamba la mankhwalawa, sulfonylureas amalembedwa, koma amatha kuvutitsa kagayidwe kazakudya, kamene kamayambitsa matenda a shuga a sodium modell. Kuyan'anira kunenepa kwanu ndi gawo lofunikira la mankhwalawa chifukwa kunenepa kwambiri kumawonjezera matendawa ndikuwapanikiza mankhwalawo.

Choyamba, mankhwala omwe matendawa adayamba kudwala ayenera kutha. Nthawi zambiri, dokotala amasankha ma analogi osavulaza. Malinga ndi malangizo azachipatala, ndibwino kuphatikiza mapiritsi ndi jakisoni wa insulin. Chithandizo choterechi chimapatsa mwayi kubwezeretsa maselo a pancreatic omwe amachititsa kuti maselo a insulin apangidwe. Zitatha izi, matendawa amatha kuthana ndi vuto la kudya.

Makanema okhudzana nawo

Kodi shuga ya steroid ndi chiyani? Mayankho mu kanema:

Chithandizo cha matenda a shuga a steroid chitha kuyenda bwino pokhapokha ngati wodwalayo asanyalanyaza malangizo omwe katswiri amamuwona. Ndikofunikira ngati zoyamba zizindikirika munthawi yolumikizana ndi achipatala kuti mukayezetse ndikupeza kuti mwazindikira. Pambuyo pake, adotolo adzalembera chithandizo choyenera, chomwe chingathandize pokhapokha ngati zonse zikutsatiridwa mosamalitsa.

Musaiwale kuti shuga ya steroid imachitika chifukwa chogwiritsa ntchito nthawi yayitali kulera kwa mahomoni ndi mankhwala ena ofanana. Komanso omwe ali pachiwopsezo ndi anthu onenepa kwambiri. Chifukwa chake, kuti mupewe matendawa, muyenera kusiyiratu kumwa mankhwala a mahomoni (ngati sanalengedwe ndi dokotala) ndikuyamba kuyang'anira kudya kwanu. Ndikofunikira kupangira chakudya chanu ndi zinthu zofunikira, makamaka, masamba, zipatso, zitsamba, nyemba, komanso kuchotsa shuga wovulaza, yemwe samabweretsa phindu lililonse.