AT kwa insulin > Amasanthula

Ma antibodies kupita ku insulin (AT mpaka insulin) - Awa ndi ma autoantibodies omwe thupi limapanga motsutsana ndi insulin yake. Amayimira chizindikiro chodziwika bwino chomwe chimawonetsa mtundu wa shuga. Ma antibodies awa adatsimikiza kuti apezeke mtundu 1 wa matenda a shuga komanso chifukwa cha kupezeka kwake ndi matenda a shuga 2.

Mtundu woyamba wa matenda a shuga 1 mellitus (wodalira insulin) umayamba ndi kuwonongeka kwa autoimmune pama cell a pancreatic beta. Kuwonongeka kwa maselo ndi ma antibodies awo kumachitika. Kuperewera kwenikweni kwa insulin kumachitika mthupi, chifukwa sizipangidwa ndi maselo owononga a beta. Kuzindikira kusiyanitsa mtundu 1 ndi matenda amtundu wa 2 ndikofunikira posankha njira zamankhwala ndikudziwa matendawo kwa wodwala wina. Matenda a shuga a Mtundu Wachiwiri samadziwika ndi kukhalapo kwa ma antibodies a insulin, ngakhale kuti milandu ingapo ya mtundu 2 wa shuga imafotokozedwa m'mabuku, momwe ma antibodies a insulin amapezeka mwa odwala.

AT kupita ku insulin nthawi zambiri amapezeka mwa ana omwe ali ndi matenda ashuga a mtundu woyamba, koma mwa achikulire omwe ali ndi matenda amtunduwu amatha kupezeka mosavuta. Miyezi yambiri ya insulin antibodies imatsimikizika mwa ana osakwana zaka 3. Chifukwa chake, kuwunika kwa AT kwa insulin kumatsimikizira bwino kuti matenda a shuga 1 amtundu wa ana omwe ali ndi shuga wambiri (hyperglycemia). Komabe, pakalibe hyperglycemia komanso kupezeka kwa ma antibodies ku insulin, kupezeka kwa matenda a shuga a mtundu wa 1 sikutsimikiziridwa. Nthawi yamatendawa, kuchuluka kwa ma antibodies ku insulin pang'onopang'ono kumachepa, mpaka kutha kwawo kwathunthu mwa akulu. Izi zimasiyanitsa ma antibodies awa ndi mitundu ina ya ma antibodies omwe amapezeka mu shuga, omwe amakhala osasinthika kapenanso kuwonjezeka kwa nthawi.

Heredity ndikofunikira kwambiri pakupanga matenda a shuga 1. Odwala ambiri, amtundu wamtundu wina, HLA-DR3 ndi HLA-DR4, wapezeka. Kukhalapo kwa matenda a shuga 1 amtundu woyandikira kumakulitsa chiopsezo chodwala mwa mwana nthawi 15. Mapangidwe a autoantibodies kupita ku insulin amayamba kale zisanachitike matenda oyamba a matenda ashuga. Popeza, kuti chizindikiro chake chiwonetsere, pafupifupi 90% ya ma cell a pancreatic beta ayenera kuwonongeka. Chifukwa chake, kusanthula kwa ma anti-insulin antibodies kumawerengera mwayi wokhala ndi tsogolo la anthu am'tsogolo omwe ali ndi vuto lobadwa nalo.

Ngati mwana yemwe ali ndi cholowa cham'mbuyomu asonyeza ma antibodies ku insulin, ndiye kuti chiopsezo chokhala ndi matenda amtundu 1 wazaka 10 zikubwera ndi 20%. Ngati ma antibodies awiri kapena angapo a mtundu woyamba wa shuga apezeka, ngozi ya matendawa imakwera mpaka 90%.

Ngati wodwala amalandira insulin kukonzekera (recombinant, exo native insulin) ngati chithandizo cha matenda a shuga, ndiye kuti pakapita nthawi thupi limayamba kupanga ma antibodies kwa iye. Kuwunika kwa ma antibodies kuti apange insulin pankhaniyi kudzakhala kwabwino, komabe, kusanthula sikulola kusiyanitsa ngati ma antibodies amapangidwa pa pancreatic insulin (endo native) kapena kuyambitsa ngati mankhwala (exo native). Chifukwa chake, ngati wodwalayo adapezeka molakwika ndi matenda a shuga a 2 ndipo adalandira insulin, ndiye kuti sizingatheke kutsimikizira mtundu wake wa 1 shuga mothandizidwa ndi mayeso a AT a insulin.

Kukonzekera kuwerenga

Magazi amaperekedwa kuti afufuzidwe pamimba yopanda kanthu m'mawa, ngakhale tiyi kapena khofi sikhala kunja. Ndizovomerezeka kumwa madzi opanda kanthu.

Kutalika kwa nthawi kuchokera pachakudya chotsiriza mpaka kuyesedwa ndi maola osachepera asanu ndi atatu.

Tsiku lisanafike phunzirolo, musamamwe zakumwa zoledzeretsa, zakudya zamafuta, kuchepetsa masewera olimbitsa thupi.

Kutanthauzira kwa Zotsatira

Norm: 0 - 10 magawo / ml.

Kuchulukitsa:

1. Type 1 shuga.

2. Anthu omwe ali ndi chikhalidwe chobadwa nacho cha matenda ashuga 1.

3. Mapangidwe awo a antibodies pa mankhwalawa amakonzekera insulin.

4. Autoimmune insulin syndrome - Matenda a Hirat.

Sankhani zizindikiro zomwe zikukuvutitsani, yankhani mafunso. Dziwani kuti vuto lanu ndi lalikulu bwanji komanso kuti mukaonana ndi dokotala.

Musanagwiritse ntchito zomwe zaperekedwa ndi tsamba la masamba la mareportal.org, chonde werengani mawu omwe mungagwiritse ntchito.

Pangano la ogwiritsa ntchito

Medportal.org imapereka ntchitozo malinga ndi zomwe zafotokozedwazi. Kuyamba kugwiritsa ntchito webusaitiyi, mumatsimikizira kuti mwawerengera Panganoli Pamagwiritsidwe musanayambe kugwiritsa ntchito tsamba la webusayiti, ndipo mukuvomereza zonse zomwe mgwirizanowu unakwaniritsa. Chonde osagwiritsa ntchito tsamba la webusayiti ngati simukugwirizana ndi izi.

Kufotokozera Kwa Ntchito

Chidziwitso chonse chomwe chatumidwa pamalowo ndi chongowerenga chokha, chidziwitso chomwe chatengedwa kuchokera ku magawo ena ndichachidziwitso ndipo sichotsatsa. Webusayiti ya medportal.org imapereka ntchito zomwe zimapangitsa Wogwiritsa ntchito kusaka mankhwala pazinthu zomwe adalandira kuchokera kuzipatala monga gawo la mgwirizano pakati pa malo ogulitsa mankhwala ndi tsamba la masamba a medportal.org. Kuti zitheke kugwiritsa ntchito tsambalo, zambiri zamankhwala ndi zothandizira pazakudya zimakonzedweratu ndikuchepetsedwa kuti zilembedwe chimodzi.

Webusayiti ya medportal.org imapereka ntchito zomwe zimaloleza Wogwiritsa ntchito kuti azisaka chipatala komanso zidziwitso zina zamankhwala.

Kuchepetsa ngongole

Zambiri zomwe zalembedwa muzotsatira zakusaka sizoperekedwa pagulu. Kuwongolera tsamba la tsambalo medportal.org sikutsimikizira kulondola, kutsimikiza ndi / kapena kufunikira kwa zomwe zikuwonetsedwa. Kuwongolera tsamba la tsambalo medportal.org sikuti kumayambitsa kuvulaza kapena kuwonongeka komwe mungakhale nako chifukwa chakutha kupeza kapena kulephera kufikira malowa kapena kuchokera kugwiritsidwa ntchito kapena kulephera kugwiritsa ntchito tsambali.

Pakuvomereza mfundo za panganoli, mumamvetsetsa bwino komanso mukuvomereza kuti:

Zambiri zomwe zili patsamba lino ndizongotchulidwa kokha.

Kuwongolera tsamba la tsambalo medportal.org sikutsimikizira kusowa kwa zolakwika ndi kusiyana pa zomwe zalengezedwa pamalowo komanso kupezeka kwenikweni kwa katundu ndi mitengo ya zinthu zomwe zili mufesi.

Wogwiritsa ntchitoyo amafunikira kuti amfotokozere zomwe zimamuchititsa kuti azimupatsa foni kapena kumuwuza kuti azigwiritsa ntchito mwanzeru zake.

Kuwongolera tsamba la tsambalo medportal.org sikutsimikizira kusakhalapo kwa zolakwika ndi zosiyanazi zokhudzana ndi ndandanda ya zipatala, zambiri zawo - manambala amfoni ndi ma adilesi.

Ngakhalenso Kuwongolera tsambalo medportal.org, kapena gulu lina lililonse lomwe likugwira nawo ntchito popereka chidziwitso ndiloyenera kuvulaza kapena kuwonongeka komwe mungavutike chifukwa chodalira kwathunthu pazomwe zili patsamba lino.

Oyang'anira tsambali medportal.org amayesetsa kuchita zonse mtsogolomo kuchepetsa kusiyana ndi zolakwika pazidziwitso zomwe zaperekedwa.

Kuwongolera tsamba la tsambalo medportal.org sikutsimikizira kuti kulibe kulephera kwaukadaulo, kuphatikiza pa ntchito ya pulogalamuyi. Oyang'anira tsambali medportal.org amayesetsa kuchita zonse zomwe angathe kuti athetse vuto lililonse lomwe lingachitike.

Wogwiritsa ntchito akuchenjezedwa kuti Kuwongolera kwa tsambalo medportal.org sikuyendetsa ntchito ndikuyendera zinthu zakunja, maulalo omwe akhoza kukhala pamalopo, samapereka kuvomereza zomwe zili mkati mwawo ndipo sindiye kuti akupezeka.

Oyang'anira tsambali medportal.org ali ndi ufulu wa kuyimitsa ntchito tsambalo, pang'ono kapena kusintha zonse zake, asintha pa Chigwirizano cha ogwiritsa ntchito. Zosintha zotere zimachitika pokhapokha pakuwona kwa Administration popanda kuzindikira kwa Wogwiritsa ntchito.

Mukuvomereza kuti mudawerengera panganoli.

Zotsatsa zotsatsa zomwe patsamba lake limagwirizana ndi wotsatsa limalembedwa kuti "malonda."

Kukonzekera kwa kusanthula

The biomaterial for the Study is a venous magazi. Njira zoyeserera zimachitika m'mawa. Palibe zofunika kwambiri pokonzekera, koma tikulimbikitsidwa kutsatira malamulo ena:

Pereka magazi pamimba yopanda kanthu, osapitilira maola 4 mutatha kudya.
Tsiku loti lisanachitike phunziroli, muchepetse kupsinjika kwamthupi ndi m'maganizo, osamwa mowa.
Patatsala mphindi 30 kuti asiyiretu kusuta.

Magazi amatengedwa ndi venipuncture, amaikidwa mu chubu chopanda kapena mu chubu choyesera ndi gel yolekanitsa. Ku labotale, biomaterial is centrifuged, seramu imakhala yokhayokha. Kuwerenga kwa zitsanzo kumachitika ndi enzyme immunoassay. Zotsatira zakonzedwa mkati mwa masiku 11-16 a bizinesi.

Makhalidwe wamba

Yachilengedwe kuchuluka kwa ma antibodies kupita ku insulin sizidutsa 10 U / ml. Matalikidwe amomwe amatchulidwa samadalira zaka, jenda, zinthu zakuthupi, monga mawonekedwe amachitidwe, zakudya, thupi. Mukamasulira zotsatira, ndikofunikira kuganizira kuti:

mu 50-63% ya odwala omwe ali ndi matenda a shuga 1, IAA siatulutsidwa, motero, chizindikiritso sichimawerengera kukhalapo kwa matenda
M'miyezi isanu ndi umodzi yoyambirira matendawa atayamba, kuchuluka kwa ma anti-insulin antibodies kumatsika mpaka zero, pomwe ma antibodies ena akupitilira kukula pang'onopang'ono, chifukwa chake, ndizosatheka kutanthauzira kuwunika kumayambitsa kudzipatula
kuchuluka kwa ma antibodies kudzachulukitsidwa mosasamala kanthu za kukhalapo kwa matenda ashuga ngati wodwalayo adagwiritsapo ntchito kale mankhwala a insulin.

Kuchulukitsa mtengo

Ma antibodies m'magazi amawonekera pakupanga ndi mawonekedwe a insulin. Mwa zina mwazowonjezera chizowonetsero ndi:

Matenda a shuga a insulin. Ma anti-insulin antibodies amadziwika ndi matendawa. Amapezeka mu 37-50% ya odwala akuluakulu, mwa ana chizindikiro ichi ndiwambiri.
Autoimmune Insulin Syndrome. Amaganiziridwa kuti chisonyezo ichi chimatsimikizika mwamaumboni, ndipo kupanga kwa IAA kumayenderana ndi kapangidwe ka insulin yosinthika.
Autoimmune polyendocrine syndrome. Zingapo zingapo za endocrine zimagwira nawo gawo mu nthawi yomweyo. Njira ya autoimmune mu kapamba, wowonetsedwa ndi shuga mellitus ndikupanga ma antibodies enaake, amaphatikizidwa ndi kuwonongeka kwa chithokomiro cha chithokomiro ndi tiziwalo tamadontho tambiri.
Kugwiritsa ntchito insulin pakadali pano kapena kale. Ma AT amapangidwa poyankha kukhazikitsa mahomoni obwereza.

Chithandizo Chosawerengeka

Kayezetsa magazi a antibodies kuti apange insulin ali ndi phindu la kuzindikira matenda a shuga 1. Kafukufukuyu amatengedwa kuti ndiwothandiza kwambiri kutsimikizira kuti ana ali ndi zaka zosakwana 3 ndi hyperglycemia. Ndi zotsatira za kusanthula, muyenera kulumikizana ndi endocrinologist. Kutengera ndi kafukufuku wofufuza bwino, adotolo amasankha njira zamankhwala, pakufunika koyesedwa bwino, komwe kumalola kuwonetsa kapena kukana kuwonongeka kwa autoimmune ku gland yina ya endocrine (gland gland, adrenal glands), matenda a celiac, magazi oyipa.

Momwe mungadziwire mtundu wa matenda ashuga

Pofuna kusiyanasiyana kwa mtundu wa matenda osokoneza bongo, ma autoantibodies omwe amatsogozedwa motsutsana ndi islet beta cell amawunikiridwa.

Thupi la odwala matenda ashuga amtundu 1 amapanga ma antibodies kuma cell awo kapamba. Kwa anthu odwala matenda ashuga amtundu wa 2, ma autoantibodies ofanana ndi osagwirizana.

Mtundu woyamba wa matenda ashuga, mahomoni amtundu wa insulin amakhala ngati autoantigen. Insulin ndi pancreatic autoantigen yodziwika bwino.

Hormoneyi imasiyana ndi maantiantijeni ena omwe amapezeka mu matendawa (mitundu yonse ya mapuloteni am'mapiri a Langerhans ndi glutamate decarboxylase).

Chifukwa chake, chikhazikitso chodziwika bwino cha matenda a autoimmune a kapamba mu mtundu 1 wa shuga amadziwika kuti ndi mayeso abwino a antibodies a mahomoni a insulin.

Ma Autoantibodies kupita ku insulin amapezeka m'magazi a theka la odwala matenda ashuga.

Ndi matenda amtundu wa 1 shuga, ma antibodies ena amapezekanso m'magazi omwe amatumizidwa kwa ma cell a beta a kapamba, mwachitsanzo, ma antibodies kuti glutamate decarboxylase ndi ena.

Pakadali pano matenda atazipanga:

70% ya odwala ali ndi mitundu itatu kapena kupitirirapo kwa ma antibodies.
Mtundu umodzi umawonedwa osakwana 10%.
Palibe ma autoantibodies ena mu 2-4% ya odwala.

Komabe, ma antibodies kupita ku mahomoni omwe ali ndi matenda ashuga siomwe amachititsa kuti matendawa akule. Amangowonetsa kuwonongeka kwa kapangidwe ka maselo a pancreatic. Ma antibodies a mahomoni a insulin omwe ali ndi ana 1 a shuga amatha kuonedwa pafupipafupi kuposa akulu.

Tcherani khutu! Nthawi zambiri, mwa ana omwe ali ndi matenda a shuga 1, ma antibodies omwe amapezeka ku insulin amawoneka koyamba komanso pazovuta kwambiri. Zofanana ndi izi zimanenedwanso mwa ana osakwana zaka 3.

Poganizira izi, kuyesa kwa AT lero kukuwoneka ngati kuwunika kwabwino kwambiri kwachipatala kuti kukhazikitse matenda a shuga 1 a ana.

Kuti mupeze chidziwitso chokwanira pakupezeka kwa matenda ashuga, osati kuyesedwa kwa antibody okha, komanso kupezeka kwa mitundu ina ya autoantibodies ya matenda ashuga.

Ngati mwana wopanda hyperglycemia ali ndi chizindikiro cha autoimmune lesion of Langerhans islet cell, izi sizitanthauza kuti shuga mellitus amapezeka mwa ana 1. Pamene matenda a shuga akupita patsogolo, kuchuluka kwa magalimoto otetemera kumatsika ndipo kumatha kuonekeratu.

Chiwopsezo chotengera matenda ashuga amtundu woyamba kudzera cholowa

Ngakhale kuti ma antibodies ku mahomoni amadziwika kuti ndi mtundu wodziwika kwambiri wa matenda ashuga 1, pali zochitika zina pamene ma antibodies omwe adapezeka mu mtundu 2 wa shuga.

Zofunika! Matenda a shuga amtundu woyamba amabadwa makamaka. Anthu ambiri omwe ali ndi matenda ashuga amanyamula mitundu ina yamtundu wa HLA-DR4 ndi HLA-DR3. Ngati munthu ali ndi abale ake omwe ali ndi matenda ashuga amtundu woyamba, chiopsezo choti amadwala chikuwonjezeka nthawi 15. Chiwopsezo chake ndi 1:20.

Nthawi zambiri, ma immunological pathologies omwe ali ngati chikhazikitso cha kuwonongeka kwa autoimmune kwa maselo a isanger a Langerhans amapezeka kale mtundu woyamba wa shuga usanachitike. Izi ndichifukwa choti magawo athunthu azizindikiro za matenda ashuga amafunika kuwonongeka kwa kapangidwe ka maselo a beta 80-90%.

Chifukwa chake, kuyesedwa kwa autoantibodies kungagwiritsidwe ntchito kuzindikira chiopsezo chamtsogolo cha mtundu woyamba wa shuga mwa anthu omwe ali ndi mbiri yotenga matenda amtunduwu. Kupezeka kwa chikhomo cha maselo otchedwa autoimmune lesion a Largenhans mwa odwalawa kukuwonetsa chiopsezo cha 20% chobwera ndi matenda ashuga mzaka 10 zikubwerazi.

Ngati ma insulin antibodies ofanana ndi matenda amtundu 1 amapezeka m'magazi, kuthekera kwa matendawa m'zaka 10 zotsatira mwa odwalawa kumawonjezeka ndi 90%.

Ngakhale kuti kafukufuku pa autoantibodies samalimbikitsidwa ngati kuwunika matenda a shuga 1 (izi zikugwiranso ntchito ku magawo ena a labotale), kuwunikaku kungakhale kofunikira pakuwunika ana omwe ali ndi cholowa cholemetsa malinga ndi mtundu wa matenda ashuga.

Kuphatikiza pa kuyesa kwa glucose, kumakuthandizani kuti muzindikire matenda amtundu wa 1 musanatchulidwe zizindikiro zamankhwala, kuphatikizapo matenda ashuga a ketoacidosis. Chikhalidwe cha C-peptide panthawi yodziwitsa zimaphwanyidwanso. Izi zimawerengera zabwino zatsalira a beta cell ntchito.

Ndizofunikira kudziwa kuti chiopsezo chotenga matenda mwa munthu yemwe ali ndi mayeso abwino a antibodies kuti asungidwe ndi insulin komanso kusakhalapo kwa mbiri yabwinobwino yokhudzana ndi matenda amtundu wa 1 sikusiyana ndi chiopsezo cha matendawa.

Thupi la odwala ambiri omwe amalandira jakisoni wa insulini (recombinant, exo native insulin), pakapita kanthawi amayamba kupanga ma antibodies ku mahomoni.

Zotsatira zomwe adapeza mu odwala zikhala zabwino. Komanso, sizitengera kuti kupanga ma antibodies ku insulin ndi amkati kapena ayi.

Pazifukwa izi, kusanthula sikuli koyenera kuti pakhale mtundu wina wa matenda ashuga amtundu 1 mwa anthu omwe agwiritsa kale ntchito insulin. Zomwezi zimachitikanso pomwe matenda ashuga akaganiziridwa mwa munthu yemwe adapezeka ndi matenda a 2 mwangozi, ndipo adathandizidwa ndi insulin yakale kuti akonze hyperglycemia.

Matenda ogwirizana

Odwala ambiri omwe ali ndi matenda amtundu wa 1 amakhala ndi matenda amodzi kapena angapo a autoimmune. Nthawi zambiri zimakhala zotheka kudziwa:

autoimmune chithokomiro matenda (Graves matenda, Hashimoto's chithokomiro),
Matenda a Addison (matenda a adrenal osakwanira),
matenda a celiac (celiac enteropathy) komanso magazi m'thupi.

Chifukwa chake, chizindikiro chokhala ngati autoimmune pathological cell cha beta chikapezeka ndikulemba mtundu wa 1 shuga chikutsimikiziridwa, kuyesedwa kowonjezereka kuyenera kukhazikitsidwa. Zofunikira kuti athe kupatula matenda awa.

Chifukwa chake kafukufuku amafunikira

Kupatula mtundu 1 wa shuga ndi mtundu wa 2 wodwala.
Kuneneratu kukula kwa matendawa kwa odwala omwe ali ndi mbiri yobadwa nayo, makamaka ana.

Momwe Mungaperekere Kusanthula

Kusanthula kumalembedwa pamene wodwala akuwonetsa matenda a hyperglycemia:

Kuwonjezeka kwa kuchuluka kwamkodzo.
W ludzu.
Kuchepetsa thupi osafotokoza.
Kuchulukitsa chilakolako.
Kuchepetsa chidwi cham'munsi.
Zowonongeka.
Zilonda za trophic pamiyendo.
Mabala amachiritso aatali.

Monga zikuwonekera ndi zotsatira zake

Nthawi: 0 - 10 Units / ml.

mtundu 1 shuga
Matenda a Hirat (AT insulin syndrome),
polyendocrine autoimmune syndrome,
kukhalapo kwa ma antibodies ku exo native and recombinant insulin kukonzekera.

zizolowezi
kupezeka kwa zizindikiro za hyperglycemia kumawonetsa kwambiri matenda a shuga a 2.

Insulin Antibody Concept

Ambiri ali ndi chidwi ndi: antibodies to insulin - ndi chiyani? Uwu ndi mtundu wa mamolekyulu opangidwa ndi zisa za anthu. Amawatsogolera kuti apange insulin yanu yomwe. Maselo oterewa ndi amodzi mwazidziwitso zodziwika bwino za matenda a shuga 1. Phunziro lawo ndikofunikira kuzindikira mtundu wa shuga wodalira insulin.

Matenda a shuga obwera chifukwa cha kuwonongeka kwa autoimmune maselo apadera a gawo lalikulu kwambiri la thupi. Zimayambitsa kutsekeka kwathunthu kwa mahomoni kuchokera m'thupi.

Ma antibodies a insulin amatchedwa IAA. Amapezeka mu seramu ngakhale asanayambitse timadzi ta protein. Nthawi zina amayamba kupangidwa zaka 8 isanayambike zizindikiro za matenda ashuga.

Kuwonetsedwa kwa kuchuluka kwa ma antibodies kumatengera mwachindunji zaka za wodwalayo. Mu 100% ya milandu, mapuloteni amapezeka ngati zizindikiro za matenda ashuga zimawonekera zaka 3-5 asanabadwe. Mu 20% ya milandu, maselo amenewa amapezeka mwa achikulire omwe ali ndi matenda a shuga 1.

Kafukufuku wa asayansi osiyanasiyana atsimikizira kuti matendawa amakula chaka chimodzi ndi theka - zaka ziwiri mwa anthu 40% omwe ali ndi magazi a anticellular. Chifukwa chake, ndi njira yoyambirira yodziwira kuchepa kwa insulin, zovuta za metabolic zama carbohydrate.

Kodi ma antibodies amapangidwa bwanji?

Insulin ndi mahomoni apadera omwe amapanga kapamba. Amachita ntchito yochepetsa shuga m'chilengedwe. Homoni amatulutsa maselo amtundu wa endocrine wotchedwa islets of Langerhans. Ndi mawonekedwe a shuga mellitus amtundu woyamba, insulin imasinthidwa kukhala antigen.

Mothandizidwa ndi zinthu zosiyanasiyana, ma antibodies amatha kupangidwa paokha insulin, ndi imodzi yomwe ingabayidwe. Mapuloteni apadera apangili oyamba amachititsa kuti thupi lizigwirizana. Jakisoni akapangidwa, kukana kwa mahomoni kumapangidwa.

Kuphatikiza pa antibodies kupita ku insulin, ma antibodies ena amapangidwa mwa odwala omwe ali ndi matenda osokoneza bongo. Nthawi zambiri panthawi yodziwitsa, mutha kudziwa kuti:

70% yamaphunziro ali ndi mitundu itatu yama antibodies,
10% ya odwala ndi eni amtundu umodzi wokha,
Odwala a 2-4% alibe maselo enaake mu seramu yamagazi.

Ngakhale kuti ma antibodies nthawi zambiri amawonetsedwa mu mtundu 1 wa shuga, pakhala pali milandu pomwe amapezeka a matenda a shuga a mtundu wachiwiri. Matendawo oyamba nthawi zambiri amatengera kwa makolo athu. Odwala ambiri amanyamula amtundu womwewo wa HLA-DR4 ndi HLA-DR3. Ngati wodwalayo ali ndi abale ake omwe ali ndi matenda amtundu woyamba, chiopsezo chodwala chikuwonjezeka nthawi 15.

Zowonetsa phunziroli pa ma antibodies

Magazi a venous amatengedwa kuti awoneke. Kafukufuku wake amalola kuti azindikire matenda ashuga koyambirira. Kusanthula ndikofunikira:

Kupanga mtundu wosiyanitsa,
Kupeza zizindikiro za prediabetes,
Tanthauzo lakudziwikiratu ndi kuwunika kwa ngozi,
Zoganiza za kufunikira kwa insulin.

Phunziroli limachitika kwa ana ndi akulu omwe ali ndi abale apamtima omwe ali ndi matendawa. Zimathandizanso mukamayang'ana maphunziro omwe ali ndi vuto la hypoglycemia kapena kulekerera shuga.

Mawonekedwe a kusanthula

Magazi a Venous amasonkhanitsidwa mu chubu choyesera chopanda ndi gel yolekanitsa. Tsamba la jakisoni limapinidwa ndi mpira wa thonje kuti magazi asiye kutuluka. Palibe kukonzekera kovuta kwa phunziroli komwe kumafunikira, koma, monga mayeso ena ambiri, ndibwino kupereka magazi m'mawa.

Pali malingaliro angapo:

Kuchokera pachakudya chotsiriza mpaka kukaperekedwa kwa zinthu zosapindulitsa, pafupifupi maola 8 ayenera kudutsa,
Zakumwa zokhala ndi zakumwa zoledzeretsa, zonunkhira komanso zakudya yokazinga siziyenera kulekedwedwa m'zakudya pafupifupi tsiku limodzi,
Dokotala angalimbikitse kukana kuchita masewera olimbitsa thupi,
Simungathe kusuta ola limodzi musanalandire,
Ndiosafunika kumwa mosiyanasiyana mukamamwa mankhwala ndikutsata njira zolimbitsa thupi.

Ngati kusanthula kukufunika kuwongolera zizindikiro muzazowunikira, ndiye kuti nthawi iliyonse ziyenera kuchitika chimodzimodzi.

Kwa odwala ambiri, ndikofunikira: payenera kukhala ndi antibodies ena a insulin konse. Zabwinobwino ndi mulingo womwe kuchuluka kwawo kumachokera ku 0 mpaka 10 mayunitsi / ml. Ngati pali maselo ochulukirapo, ndiye kuti titha kungoganiza kupangika kwa mtundu 1 wa shuga; komanso:

Matenda omwe amadziwika ndi kuwonongeka kwa autoimmune ku gland ya endocrine,
Autoimmune insulin syndrome,
Chiwopsezo cha jekeseni wa insulin.

Zotsatira zoyipa zimakhala umboni wa chizolowezi. Ngati pali matenda obwera chifukwa cha matenda ashuga, ndiye kuti wodwalayo amatumizidwa kuti akamuzindikiritse matenda a metabolic, omwe amadziwika ndi matenda a hyperglycemia.

Zotsatira za kuyesa kwa magazi kwa ma antibodies

Ndi kuchuluka kwa ma antibodies ku insulin, titha kulingalira kukhalapo kwa matenda ena a autoimmune: lupus erythematosus, matenda a dongosolo la endocrine. Chifukwa chake, asanapangire kuti adziwe matenda ndikupereka mankhwala, dotolo amatenga zonse zokhudzana ndi matendawa komanso zamkati, ndikuchita njira zina zodziwonera.

Zizindikiro zomwe zingayambitse kukayikira kwa matenda amtundu wa 1 ndi:

Ludzu lalikulu
Kuchulukitsa mkodzo
Kuchepetsa thupi
Kuchulukitsa chilakolako
Kuchepetsa maonedwe owoneka ndi ena.

Madokotala akuti 8% ya anthu athanzi amakhala ndi antibodies. Zotsatira zoyipa sizizindikiro kuti matendawa palibe.

Kuyesedwa kwa insulin sikulimbikitsidwa ngati kuyesa matenda a shuga 1. Koma kuwunikiraku ndikothandiza kwa ana omwe ali ndi cholowa chovuta. Odwala omwe ali ndi zotsatira zoyesedwa zabwino komanso osadwala, abale omwe ali pachiwopsezo ali ndi vuto lofanananso ndi maphunziro ena pagulu lomwelo.

Zinthu Zotsatira Zotsatira

Matenda a antibodies kwa insulin amapezeka kawirikawiri mwa akulu.

M'miyezi isanu ndi umodzi yoyambirira matendawa atangoyamba kumene, matendawa amatha kuchepa kwambiri mpaka kufika pozindikira kuchuluka kwawo.

Kusanthula sikulola kusiyanitsa, mankhwala opanga mapuloteni amapangidwa ku mahomoni awo kapena kutuluka (kuperekedwa kudzera mu jakisoni). Chifukwa cha kuyesedwa kwakukulu, dokotalayo amapereka njira zowonjezera zowunikira kuti atsimikizire kuti ali ndi vutoli.

Mukamapanga matenda, zotsatirazi zimakumbukiridwa:

Matenda a Endocrine amayamba chifukwa cha zochita za autoimmune motsutsana ndi maselo a kapamba anu.
Ntchito yoyendetsa ntchito imadalira mwachindunji kuchuluka kwa ma antibodies omwe amapangidwa.
Chifukwa chakuti mapuloteni omaliza amayamba kupangika patatsala nthawi yayitali kuti chithunzi chachipatala chioneke, pali zinthu zonse zofunika kuti munthu adziwe matenda ashuga amtundu woyamba.
Amadziwikanso kuti mu akulu ndi ana maselo osiyanasiyana amapanga mosiyana ndi matendawo.
Ma antibodies ku mahomoni ndiwofunikira kwambiri pakuzindikira pamene akugwira ntchito ndi odwala aang'ono ndi azaka zapakati.

Chithandizo cha odwala omwe ali ndi mtundu 1 wa matenda a shuga ndi ma antibodies a insulin

Mlingo wa ma antibodies kuti mupeze insulin m'magazi ndi njira yofunika kwambiri yodziwunikira. Zimathandizira adotolo kuwongolera chithandizo, kuletsa kukula kwa kukana kwa chinthu chomwe chimathandizira kuchuluka kwa glucose m'magazi wamba. Kutsutsa kumawonekera ndikumayambitsa kukonzekera kosayeretsedwa bwino, komwe mumapezekanso proinsulin, glucagon ndi zinthu zina.

Ngati ndi kotheka, mapangidwe oyera oyeretsedwa (nthawi zambiri nkhumba) amaperekedwa. Samatsogolera pakupanga ma antibodies.
Nthawi zina ma antibodies amapezeka m'magazi a odwala omwe amathandizidwa ndi mankhwala a hypoglycemic.