Mankhwala Lipothioxone: malangizo ntchito

chotsani madzi kuchokera ku chikasu chopepuka chikasu chikasu.

Mankhwala

Thioctic acid (alpha-lipoic acid) - mankhwala am'mbuyomu antioxidant (omanga ma free radicals), amapangidwa mthupi ndi oxidative decarboxylation a alpha-keto acid. Monga coenzyme ya mitochondrial multenzyme complexes, imakhudzidwa ndi oxidative decarboxylation ya pyruvic acid ndi alpha-keto acid. Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera glycogen m'chiwindi, komanso kuthana ndi insulin. Mwa chikhalidwe cha zochita zamapangidwe amtundu, zimakhala pafupi ndi mavitamini a B. Amatenga nawo gawo la lipid ndi carbohydrate metabolism, imalimbikitsa kagayidwe ka cholesterol, ndikuwongolera ntchito ya chiwindi. Ali ndi hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Amakweza ma neuroni a trophic.

Pharmacokinetics
Ndi makonzedwe amtsempha, nthawi yofikira kuchuluka kwambiri ndi 10-11 mphindi, kupezeka kwa ndende 25 25 μg / ml, dera lomwe lili pansi pa nthawi yokhazikika ndi pafupifupi 5 μg h / ml. Bioavailability ndi 30%.
Thioctic acid imakhala ndi "gawo loyamba" kudzera mu chiwindi. Kapangidwe ka metabolites kumachitika chifukwa cha kupendekeka kwa mbali ndi oxidation.
Kuchuluka kwa magawidwe ndi pafupifupi 450 ml / kg. Thioctic acid ndi ma metabolites ake amuchotsa impso (80-90%). Kutha kwa theka-moyo ndi mphindi 20-50. Chilolezo chonse cha plasma ndi 10-15 ml / min.

Mlingo ndi makonzedwe

Mankhwalawa adakonzekera kukonzekera njira yothetsera kulowetsedwa pambuyo poyambira kuchepetsedwa mu isotonic sodium chloride solution.
Woopsa mitundu ya matenda ashuga kapena uchidakwa polyneuropathy, 300-600 mg 1 nthawi patsiku ayenera kutumikiridwa monga kulowetsedwa kulowetsedwa kulowetsedwa. Kulowetsedwa kwa mtsempha kuyenera kuperekedwa mkati mwa mphindi 50. Mankhwala tikulimbikitsidwa kuti mugwiritse ntchito pakatha milungu iwiri. Kenako, mutha kupitiliza kumwa thioctic acid mkati mwa 300-600 mg patsiku. Kutalika kochepa kwa mapiritsi ndi miyezi itatu.

Zotsatira zoyipa

Ndi mtsempha wamitsempha, kupweteka, diplopia, kutulutsa zotupa mu mucous nembanemba, khungu, thrombocytopathy, hemorrhagic zidzolo (purpura), thrombophlebitis ndizosowa kwambiri. Ndi makonzedwe achangu, kuwonjezeka kwa kuthinikizidwa kwa intracranial ndikotheka (kuwoneka kumverera kwa kulemera kumutu), kuvutika kupuma. Zotsatira zoyipa sizimadzokha.
Thupi lawo siligwirizana n`zotheka: urticaria, zokhudza zonse zoyipa (mpaka chitukuko cha anaphylactic mantha).
Hypoglycemia imatha kukhazikika (chifukwa cha kutuluka kwa glucose).

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo ndi njira yokhayo yomwe ikukonzekera njira yothetsera kulowetsedwa: madzi amtundu wowonekera kuchokera ku mtundu wobiriwira mpaka kuwala wachikaso mumtundu (mkatoni paketi 1 contour cell kapena pulasitiki ya pulasitiki yokhala ndi ma ampoules 5 a 12 kapena 24 ml, ndi malangizo ogwiritsira ntchito Lipothioxone).

Zopangidwa pa 1 ampoule amodzi:

• yogwira ntchito: thioctic (α-lipoic) acid - 300 kapena 600 mg (mu mawonekedwe a meglumine thioctate - 583.86 kapena 1167.72 mg, wopangidwa chifukwa cha kuyanjana kwa thioctic acid ndi meglumine),
• othandizira zigawo (300/600 mg): anhydrous sodium sulfite - 6/12 mg, macrogol-300 - 2400/4800 mg, meglumine - mpaka pH 8-9 (12.5-35 mg / 25-70 mg), edetate disodium - 6/12 mg, madzi a jakisoni - mpaka 12/24 ml.

Mankhwala

Thioctic (α-lipoic) acid ndi antioido wa amkati omwe amamanga ma radicals aulere, mapangidwe ake omwe m'thupi limachitika nthawi ya oxidative decarboxylation ya α-keto acid. Monga coenzyme ya mitochondrial multenzyme complexes, thioctic acid imaphatikizidwa mu oxidative decarboxylation ya α-keto acid ndi pyruvic acid.

Lipothioxone ali ndi hepatoprotective, hypolipidemic, hypoglycemic ndi hypocholesterolemic kwenikweni. Mwa chikhalidwe cha zamankhwala am'mthupi za α-lipoic acid ili pafupi ndi mavitamini a gulu B.

Zotsatira zazikulu za thioctic acid:

• kutsika kwa ndende ya magazi,
• kuchuluka kwa glycogen m'chiwindi,
• kuthana ndi insulin,
• kutenga nawo gawo pa chakudya ndi lipid kagayidwe,
• kukondoweza kwa mafuta a cholesterol,
• kukonza magwiridwe antchito a chiwindi ndi kuwonjezera trophism ya neurons.

Pharmacokinetics

Kuchuluka kwa thioctic acid wokhala ndi mtsempha wama khosi kumatheka mwa mphindi 10-11, ndi 0.025-0.038 mg / ml. Dera lomwe kuli pansi pajika - "ndende - nthawi"

0,005 mg h / ml. Bioavailability pamlingo wa 30%.

Thupi limakhala ndi mphamvu yoyamba kudutsa m'chiwindi. Mapangidwe a metabolite mapangidwe amalumikizidwa ndi conjugation ndi makutidwe ndi okosijeni am'mbali.

450 ml / kg. Kutulutsa zinthu ndi ma metabolites ake amapezeka makamaka ndi impso (kuyambira 80 mpaka 90%). Kuchotsa hafu ya moyo kumapangitsa mphindi 20-50. Chilolezo chonse cha plasma chili mndandanda wa 10-15 ml / min.

Lipothioxone, malangizo ntchito: njira ndi mlingo

Lipothioxone imayang'aniridwa mwa njira ya infusions pambuyo pa kulowetsedwa mu isotonic sodium chloride solution.

Woopsa matenda a pathology, yankho limaperekedwa kamodzi patsiku mlingo wa 300-600 mg kukapumira kwa mphindi 50.

Kutalika kwa mankhwala ndi milungu iwiri kapena itatu. Pakutha kwa nthawi imeneyi, chithandizo chimapitilizidwa ndi kamwa yokhala ndi thioctic acid yemweyo muyezo wa miyezi 3.

Zotsatira zoyipa

Nthawi zosowa kwambiri, motsutsana ndi kukhazikitsidwa kwa Lipothioxone, pamakhala zovuta zamkati mwa kugwidwa, diplopia, thrombophlebitis, zotupa za pakhungu pakhungu ndi mucous membrane, zotupa za hemorrhagic (phenura), thrombocytopathy.

Ngati njira yothetsera vutoli ingalowe mwachangu, zovuta za kupuma komanso kukhudzika kwachulukidwe kumatha kuchitika (kuwonetsedwa ngati kumverera kolemetsa m'mutu). Zinthu zoyipa izi nthawi zambiri zimakhala zokha.

Urticaria, zokhudza zonse ziwonetsero (mpaka anaphylactic mantha) zitha kuchitika.

Kupititsa patsogolo kukhathamira kwa shuga kungayambitse hypoglycemia.

Malangizo apadera

Odwala omwe ali ndi matenda ashuga, makamaka kumayambiriro kwa kugwiritsa ntchito Lipothioxone, amafunikira kuwunikira pafupipafupi kuchuluka kwa shuga m'magazi. Nthawi zina mlingo wa othandizira a hypoglycemic umayenera kuchepetsedwa.

Ndikulimbikitsidwa kuti musamamwe mowa munthawi ya mankhwalawa, chifukwa amachepetsa mphamvu ya mankhwalawo.

Ampoules ochokera phukusi amayenera kuchotsedwa pokhapokha asanagwiritse ntchito, chifukwa Lipothioxone ili ndi zithunzi zapamwamba kwambiri. Pa kulowetsedwa, ndikofunikira kuteteza vial yankho kuti isayerekezedwe ndi kuwala pakukulunga ndi foil ya aluminiyamu kapena kuyiyika m'matumba osapepuka.

Pambuyo pa dilution, lipothioxone iyenera kugwiritsidwa ntchito kwa maola 6, malinga ngati imasungidwa m'malo amdima.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mu / mu (ndege, dontho), mu / m.

Mitundu yayikulu ya polyneuropathies - iv pang'onopang'ono (50 mg / min), 600 mg kapena iv drip, mu 0.9% NaCl yankho kamodzi patsiku (muzovuta, mpaka 1200 mg imayendetsedwa) kwa masabata a 2-4. Mu / kumayambitsa ndikotheka ndi mothandizidwa ndi perfuser (nthawi ya makonzedwe - osachepera mphindi 12).

Ndi jekeseni / m malo omwewo, mlingo wa mankhwalawa suyenera kupitirira 50 mg.

Pambuyo pake, amasinthana ndi mankhwala othandizira pakamwa kwa miyezi itatu.

Zotsatira za pharmacological

Coenzyme ya mitochondrial multenzyme maofesi omwe amaphatikizidwa mu oxidative decarboxylation wa pyruvic acid ndi alpha-keto acid amathandizira kwambiri pakulimbitsa thupi. Mwa chikhalidwe cha biochemical action, thioctic (alpha-lipoic) acid ndi wofanana ndi mavitamini a B. Ndi antioididant wamkati. Amatenga nawo gawo la lipid ndi carbohydrate metabolism, ali ndi lipotropic, amakhudza cholesterol metabolism, amasintha ntchito ya chiwindi, amakhala ndi mphamvu pobweretsa poizoni ndi mchere wambiri ndi zakumwa zina zoledzeretsa. Zotsatira za kagayidwe kazakudya zimawonetsedwa mu kuchepa kwa shuga wamagazi komanso kuchuluka kwa glycogen m'chiwindi, komanso kuthana ndi insulin. Amakweza ma neuroni a trophic.

Mafunso, mayankho, ndemanga pa mankhwala a Lipothioxone

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe amaphatikizidwa ndi zomwe amapanga ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Analogs ndi mitengo ya mankhwala Lipothioxone

mapiritsi okutira

kulowetsedwa njira

mapiritsi okhala ndi filimu

mapiritsi okutira

kulowetsedwa njira yang'anani

mapiritsi okhala ndi filimu

mapiritsi okhala ndi filimu

kulowetsedwa njira yang'anani

kulowetsedwa njira yang'anani

mapiritsi okhala ndi filimu

mapiritsi okutira

yankho la mtsempha wa magazi

kulowetsedwa njira yang'anani

mapiritsi okhala ndi filimu

mapiritsi okutira

mapiritsi okhala ndi filimu

gwiritsani ntchito yankho la intravenous makonzedwe

kulowetsedwa njira yang'anani

kulowetsedwa njira yang'anani

kulowetsedwa njira yang'anani

mapiritsi okhala ndi filimu

Mavoti onse: madokotala 76.

Zambiri za omwe adayankha mwapadera:

Kuchita ndi mankhwala ena

Alpha lipoic acid (monga njira yothetsera kulowetsedwa) amachepetsa mphamvu ya cisplatin.
Pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito insulin ndi mankhwala ena amkamwa a hypoglycemic, kuwonjezeka kwa zotsatira za hypoglycemic kumawonedwa.
Alpha-lipoic acid imapanga zovuta kusungunuka zovuta ndi mamolekyulu a shuga (mwachitsanzo, yankho la levulose), chifukwa chake, sizigwirizana ndi yankho la glucose, yankho la Ringer, komanso ndi mankhwala (kuphatikiza mayankho awo) omwe amakhala ndi magulu a disulfide ndi SH .

Kuyanjana kwa mankhwala osokoneza bongo

• cisplatin: zake zimachepa
• insulin ndi ena othandizira pakamwa a hypoglycemic: mphamvu ya hypoglycemic imatheka,
• glucose solution, yankho la Ringer, kuphatikiza komwe kumachitika ndi discride ndi magulu a SH (kuphatikiza mayankho awo): kusayenerana, popeza kupangidwa kovuta kusungunuka kwa α-lipoic acid ndi ma mamolekyulu a shuga kumachitika.

Ndemanga za Lipothioxone

Ndemanga za Lipothioxone ndi ochepa. Nthawi zina, akatswiri amawona kukonzekera kwa zoyipa, nthawi zambiri mwa mtundu wa hypoglycemia (kwa mlingo wa 600 mg). Matenda am'mimba komanso kuchuluka kwa michere ya chiwindi kumayang'anidwanso.

Zina mwa zabwino zambiri zimaphatikizapo njira yabwino komanso yotsika mtengo.

Lipothioxone: mitengo pamafakitale apakompyuta

Lipothioxone 25 mg / ml kuganizira kwambiri njira yothetsera kulowetsedwa 12 ml 5 ma PC.

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Pogwira ntchito, ubongo wathu umagwiritsa ntchito mphamvu zambiri zofanana ndi babu la 10-watt. Chifukwa chake chithunzi cha babu wapamwamba pamutu panu panthawi yomwe chikuwoneka ngati chosangalatsa sichili kutali ndi chowonadi.

Asayansi aku America adayesera mbewa ndipo adati madzi amadzi amalepheretsa kukula kwa atherosulinosis yamitsempha yamagazi. Gulu limodzi la mbewa limamwa madzi am'madzi, ndipo lachiwiri ndi madzi a mavwende. Zotsatira zake, zombo za gulu lachiwiri zinali zopanda ma cholesterol.

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Ngati mungagwere kuchokera pabulu, mukulola khosi lanu kusiyana ndi kugwa kuchokera pa kavalo. Ingoyesani kutsutsa mawu awa.

Zoposa $ 500 miliyoni pachaka zimagwiritsidwa ntchito pa mankhwala azisamba okha ku United States. Kodi mukukhulupilirabe kuti njira yoti mugonjetse ziwengo ikapezeka?

Mwazi wa munthu "umayenda" m'matumbo omwe akukakamizidwa kwambiri, ndipo ngati umphumphu wake waphwanyidwa, amatha kuwombera mpaka 10 metres.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

Ntchito yomwe munthu samakonda imakhala yovulaza psyche yake kuposa kusowa kwa ntchito konse.

Mimba ya munthu imagwira ntchito yabwino ndi zinthu zakunja komanso popanda chithandizo chamankhwala. Madzi am'mimba amadziwika kuti amasungunula ngakhale ndalama.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Malinga ndi kafukufuku wa WHO, kuyankhulana kwa theka la ola limodzi pafoni kumawonjezera mwayi wokhala ndi chotupa muubongo ndi 40%.

Mabakiteriya mamiliyoni ambiri amabadwa, amoyo ndi kufa m'matumbo athu. Amatha kuwoneka pa kukula kwakukulu, koma ngati atakhala palimodzi, akhoza kukhala mu kapu ya khofi yokhazikika.

Kutentha kwambiri kwa thupi kudalembedwa ku Willie Jones (USA), yemwe adamulowetsa kuchipatala ndi kutentha kwa 46,5 ° C.

Impso zathu zimatha kuyeretsa malita atatu a magazi mphindi imodzi.

Nthawi yayitali yotsala ndiyotsika ndi yoyipa.

Mafuta a nsomba akhala akudziwika kwazaka zambiri, ndipo munthawi imeneyi zatsimikiziridwa kuti zimathandizira kupewetsa kutupa, kuchepetsa ululu wolumikizana, kukonza sos.

Zithunzi za 3D

Wopanga

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