Reduxin® (Reduxin)

Reduxine akupezeka mu mawonekedwe a makapisozi: kukula No. 2, buluu ndi buluu, zomwe zili mkati mwake zimakhala zoyera kapena zoyera zokhala ndi chikasu chachikasu cha ufa (10 iliyonse mumatumba, pamakatoni a 3 kapena 6 mapaketi).

Zinthu zothandizika (mu 1 kapisozi):

• Ma cell a Microcrystalline - 158,5 mg kapena 153.5 mg,
• Sibutramine hydrochloride monohydrate - 10 mg kapena 15 mg.

Zothandiza zothandizira: calcium stearate.

Mapangidwe a chipolopolo cha kapisozi: gelatin, utoto wa titanium dioxide, utoto wokhala ndi utoto wabuluu, utoto azorubine (makapisozi 10 mg).

Contraindication

• Matenda osagwirizana a magazi (kuthamanga kwa magazi pamwamba pa 145/90 mm Hg)
• Matenda a mtima, matenda am'mitsempha, matenda a mtima, kupunduka kwa mtima, matenda a mtima, tachycardia, matenda amisala
• Kusokonekera kwambiri kwa impso ndi / kapena chiwindi,
• Nkhupakupa,
• Matenda amisala
• Mavuto akulu kudya (bulimia amanosa kapena anorexia),
• Benign Prostatic hyperplasia
• Kupezeka kwa zoyambitsa organic kunenepa (hypothyroidism, etc.),
• Thirotooticosis,
• Angle -otseka glaucoma,
• Mankhwala, mankhwala osokoneza bongo,
• Pheochromocytoma,
• Kugwiritsa ntchito pamodzi mankhwala a antipsychotic, antidepressant ndi mankhwala ena omwe amagwiritsa ntchito dongosolo lamanjenje lamkati,
• Kugwiritsa ntchito nthawi yomweyo kapena kutsata kwa masabata awiri asanaikidwe Reduxine monoamine oxidase inhibitors (mwachitsanzo ephedrine, ethylamfetamine, fenfluramine, phentermine, dexfenfluramine),
• Kugwiritsa ntchito mankhwala ena kuti muchepetse kulimbitsa thupi kwapakatikati, komanso mankhwala okhala ndi tryptophan komanso mankhwala osokoneza bongo;
• Ana osakwana zaka 18
• Mimba komanso kuyamwa
• Okalamba opitilira 65,
• Hypersensitivity pazinthu zilizonse za mankhwala.

Wachibale (samalani mankhwalawa mosamala):

• Matenda oopsa a arterial (mbiri yakale komanso yolamulidwa),
• Kulephera kwazungulira kwa magazi,
• Mbiri ya arrhythmias,
• Matenda a m'mitsempha ya coronary (kuphatikizapo mbiri ya)
• Aimpso owonongeka ndi / kapena chiwindi chambiri komanso zowonda kwambiri,
• Cholelithiasis,
• Mbiri yamawu olankhulira pamoto ndi oyendetsa galimoto,
• Matenda a mitsempha, kuphatikizapo kulanda ndikubweza m'maganizo (kuphatikizapo mbiri).

Mlingo ndi makonzedwe

Makapisozi a Reduxine amatengedwa pakamwa kamodzi patsiku, asanadye kapena panthawi ya chakudya. Kapholo kam'meza lonse ndikusambitsidwa ndi madzi okwanira kapena madzi ena.

Mlingo umayikidwa payekha ndipo zimatengera kulekerera kwa mankhwalawa komanso kuthandizira kwake kwamankhwala. Mlingo woyambayo nthawi zambiri umakhala 10 mg. Ngati mankhwalawa salekerera bwino, mutha kuyamba kumwa ndi 5 mg.

Ndi kuchepa kwa thupi pochepera 5% m'mwezi woyamba wa mankhwala, mlingo wa mankhwalawa umakulitsidwa mpaka 15 mg patsiku. Odwala omwe amalephera kutaya 5% kapena kupitilira kwa kulemera kwawo koyamba mkati mwa miyezi itatu, chithandizo chimayimitsidwa. Mankhwalawa sayenera kupitilizidwa ngakhale, atachepetsa thupi, wodwalayo amawonjezeranso 3 kg kapena kuposa.

Kutalika konse kwa chithandizo cha Reduxin sikupitilira zaka 2, popeza palibe chidziwitso chazotetezeka ndikuyenda bwino kwa mankhwalawa ndi chithandizo chambiri.

Chithandizo chikuchitika moyang'aniridwa ndi dokotala wodziwa ntchito yolimbana ndi kunenepa kwambiri. Therapy imalimbikitsidwa kuti iphatikizidwe ndi masewera olimbitsa thupi komanso zakudya.

Gulu la mankhwala

Mankhwala

Reduxin ® ndi chophatikiza chophatikizika chomwe zochita zake zimachitika chifukwa cha zigawo zake.

Sibutramine Ndi mankhwala osokoneza bongo ndipo amakhala ndi zotsatira zake mu vivo chifukwa cha metabolites (ma pulayimale oyambira ndi sekondale) omwe amalepheretsa kubwezeretsanso kwa monoamines (serotonin, norepinephrine ndi dopamine). Kuwonjezeka kwa zomwe zili mu ma neurotransmitters mu ma synapses kumawonjezera zochitika zapakati pa 5-HT-serotonin ndi adrenergic receptors, zomwe zimapangitsa kuti pakhale kuwonjezereka kwa satiety ndi kutsika kwa kufunikira kwa chakudya, komanso kuwonjezeka kwa mafuta opanga. Zoyambitsa beta mwachindunji₃-adrenoreceptors, sibutramine amachita zotumphukira adipose. Kutsika kwa kulemera kwa thupi kumayendera limodzi ndi kuchuluka kwa plasma ndende ya HDL komanso kuchepa kwa chiwerengero cha triglycerides, cholesterol yathunthu, LDL ndi uric acid. Sibutramine ndi ma metabolites ake sizikhudza kutulutsidwa kwa ma monoamines, osaletsa ma MAO, omwe ali ndi mgwirizano wotsika kwa chiwerengero chachikulu cha ma neurotransmitter receptors, kuphatikizapo serotonin (5-HT₁5-NT_1A5-NT_1B5-NT_2C), adrenergic (beta₁-, beta₂-, beta₃-, alpha₁-, alpha₂-), dopamine (D₁, D₂), muscarinic, histamine (N₁), benzodiazepine ndi glutamate (NMDA) receptors.

MCC Ndi enterosorbent, ili ndi mphamvu za ufiti komanso zotsatira zosakhudzana ndi kutulutsidwako. Amamanga ndikuchotsa tizilombo tating'onoting'ono tambiri, zopangidwa ndi ntchito yofunika kwambiri, poizoni wa chilengedwe komanso chilengedwe, ma allergen, xenobiotic, komanso kuchuluka kwazinthu zambiri za metabolic komanso metabolites zomwe zimayambitsa kukula kwa endo native toxicosis.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, imatengedwa mwachangu kuchokera kumimba yotseguka ndi pafupifupi 77%. Pa gawo loyambirira kudzera pachiwindi, limadutsa biotransformation mothandizidwa ndi CYP3A 4 isoenzyme ndikupanga ma metabolites awiri ogwira ntchito - monodemethylsibutramine (M1) ndi doesmethylsibutramine (M2). Pambuyo pa limodzi mlingo wa 15 mg C_max m'magazi am'magazi, M1 ndi 4 ng / ml (3.2-4.8 ng / ml), M2 ndi 6.4 ng / ml (5.6-7.2 ng / ml). C_max akwaniritsidwa pambuyo pa maola 1.2 (sibutramine), maola 3-4 (M1 ndi M2). Kudya Zapakati Pano_max metabolites ndi 30% ndikuwonjezera nthawi kuti mufikire izo 3 maola osasintha AUC. Imagawidwa mwachangu pazovala. Kuyankhulana ndi mapuloteni ndi 97 (sibutramine) ndi 94% (M1 ndi M2). C_ss yogwira metabolites mu madzi am`magazi amafikira patatha masiku 4 atayamba kugwiritsa ntchito ndipo pafupifupi kawiri kuchuluka kwa plasma atamwa kamodzi. T_1/2 sibutramine - maola 1,1, M1 - 14 maola, M2 - maola 16. Ma metabolites omwe amagwira ntchito amakhala ndi hydroxylation ndi kuphatikizika kwa mapangidwe a metabolites osagwira, omwe amafotokozedwa makamaka ndi impso.

Magulu apadera a odwala

Paulo Zomwe zilipo zochepa zomwe sizikusonyeza kukhalapo kwa kusiyana kwakukulu kwamankhwala mu pharmacokinetics mwa amuna ndi akazi.

Ukalamba. Pharmacokinetics mu okalamba athanzi labwino (pafupifupi zaka - 70 zaka) ali ofanana ndi achinyamata.

Kulephera kwina. Kulephera kwamankhwala sikumakhudza AUC ya metabolites yogwira M1 ndi M2, kupatula kwa metabolite M2 mwa odwala omwe ali ndi vuto la a-end reasy under dialysis.

Kulephera kwa chiwindi. Odwala omwe ali ndi chiwindi chochepa cholephera patatha gawo limodzi la sibutramine AUC, ma metabolites omwe amagwira M1 ndi M2 ndi 24% kuposa anthu athanzi.

Mimba komanso kuyamwa

Popeza pakadali pano palibe chiwerengero chokwanira chokwanira cha maphunziro okhudzana ndi chitetezo cha zovuta za sibutramine pa mwana wosabadwayo, mankhwalawa amatsutsana panthawi yapakati.

Amayi omwe ali ndi zaka zakubala ayenera kugwiritsa ntchito njira zakulera pamene akumamwa Reduxin ®.

Amakanizidwa kutenga Reduxin ® nthawi yoyamwitsa.

Zotsatira zoyipa

Nthawi zambiri, zoyipa zimachitika kumayambiriro kwa mankhwalawa (mu masabata 4 oyamba). Kuuma kwawo komanso ma pafupipafupi kumafooka pakapita nthawi. Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosintha. Zotsatira zoyipa, kutengera mphamvu ya ziwalo ndi ziwalo zamagulu, zimaperekedwa motere: pafupipafupi (≥10%), nthawi zambiri (≥1%, koma dongosolo lamkati lamanjenje: Nthawi zambiri - pakamwa youma komanso kugona, nthawi zambiri - kupweteka mutu, chizungulire, nkhawa, paresthesia, komanso kusintha kwa kukoma.

Kuchokera ku CCC: Nthawi zambiri - tachycardia, palpitations, kuthamanga kwa magazi, vasodilation.

Kukwera kwapakati pa kuthamanga kwa magazi pakupuma ndi 1-3 mm Hg kumawonedwa. ndi kuchuluka kwapamwamba kwamitima ya 3 000 kumenyedwa / mphindi. Nthawi zina, kuchuluka kwambiri kwa magazi ndi kuthamanga kwa mtima sikumachotsedwa. Kusintha kwamankhwala kwakukulu pakukwera kwa magazi ndi zamkati zimalembedwa makamaka kumayambiriro kwa chithandizo (masabata 4 mpaka 8).

Kugwiritsa ntchito Reduxin ® kwa odwala omwe ali ndi kuthamanga kwa magazi: onani "Contraindication" ndi "Malangizo Apadera".

Kuchokera m'mimba: pafupipafupi - kusowa kwa chilimbikitso ndi kudzimbidwa, nthawi zambiri - mseru komanso kukokoka kwa zotupa m'mimba. Ndi chizolowezi chodzimbidwa m'masiku oyambilira, kuyang'anira kuthamangitsidwa kwa ntchito yamatumbo ndikofunikira. Ngati kudzimbidwa kumachitika, siyani kumwa ndikutsukanso.

Pa khungu: Nthawi zambiri - kuchuluka thukuta.

Nthawi zina, chithandizo ndi sibutramine chafotokozanso izi: pachimake interstitial nephritis, magazi, Shenlein-Genoch purpura (zotupa pakhungu), zopweteka, thrombocytopenia, osakhalitsa kuchuluka kwa ntchito ya chiwindi michere mu magazi.

Mu maphunziro a malonda otsatsa, zina zoyipa zomwe zidafotokozedwa, zidafotokozeredwa pansipa, ndi mabungwe:

Kuchokera ku CCC: fibrillation ya atria.

Kuchokera ku chitetezo chamthupi: Hypersensitivity reaction (kuchokera pamatumbo oyamba pakhungu ndi urticaria mpaka angioedema (edema ya edi ya Quincke) ndi anaphylaxis.

Mavuto amisala: psychosis, mayiko oganiza zodzipha, kudzipha komanso mania. Zinthu zotere zikachitika, mankhwalawo ayenera kusiyidwa.

Kuchokera ku dongosolo lamanjenje: kukhumudwa, kukumbukira kwakanthawi kochepa.

Kuchokera kumbali ya gawo la masomphenyawo: masomphenya osalala (chophimba pamaso).

Kuchokera m'mimba: kusanza, kusanza.

Pa khungu ndi subcutaneous minofu: alopecia.

Kuchokera ku impso ndi kwamkodzo thirakiti: kusungika kwamikodzo.

Kuchokera pakubala: kusokonezeka kwa chikodzo / kupindika, kusabala, kusamba kwa msambo, kutaya magazi muchiberekero.

Kuchita

Inhibitors a microsomal oxidation, kuphatikizapo zoletsa za CYP3A 4 isoenzyme (kuphatikiza ketoconazole, erythromycin, cyclosporin) zimachulukitsa kuchuluka kwa plasma ya sibutramine metabolites ndi kuwonjezeka kwa kugunda kwa mtima komanso kuwonjezeka koperewera kopitilira muyeso wa QT.

Rifampicin, macrolide maantibayotiki, phenytoin, carbamazepine, phenobarbital ndi dexamethasone angathandizire kagayidwe ka sibutramine. Kugwiritsa ntchito munthawi yomweyo mankhwala angapo omwe amathandizira kuti serotonin ikhale m'magazi a m'magazi kungayambitse kuyanjana kwakukulu. Nthawi zina, kugwiritsa ntchito mankhwala munthawi yomweyo Reduxin ® ndi ma SSRIs (mankhwalawa pofuna kuthana ndi nkhawa), mankhwala ena ochizira migraine (sumatriptan, dihydroergotamine), potent analgesics (pentazocine, pethidine, fentanyl) kapena mankhwala antitussive (dextromethorphan) amatha. serotonin syndrome.

Sibutramine siyimakhudzanso mphamvu yoletsa kubereka pakamwa.

Ndi makonzedwe omwewo a sibutramine ndi mowa, sizinawonjezeke pazomwe zimapangitsa mowa. Komabe, mowa samaphatikizidwa kwathunthu ndi njira zomwe zingalimbikitsidwe pakudya ma sibutramine.

Pogwiritsa ntchito munthawi yomweyo mankhwala ena omwe ali ndi sibutramine omwe amakhudza hemostasis kapena kupatsidwa zinthu za m'magazi, chiopsezo chotaya magazi chimakulanso.

Kuphatikiza kwa mankhwalawa ndi munthawi yomweyo kugwiritsa ntchito sibutramine ndi mankhwala omwe amalimbikitsa kuthamanga kwa magazi ndi kugunda kwa mtima sikukumveka bwinobe. Gulu la mankhwalawa limaphatikizira mankhwala opatsirana, antitussive, ozizira komanso anti-allergic, omwe amaphatikizapo ephedrine kapena pseudoephedrine. Chifukwa chake, pakakhala munthawi yomweyo kugwiritsa ntchito mankhwalawa ndi sibutramine, muyenera kusamala. Kugwiritsa ntchito sibutramine pamodzi ndi mankhwalawa kuti muchepetse kulemera kwa thupi, kugwira ntchito yamchiberekero yamanjenje, kapena mankhwala ochizira matenda amisala.

Mlingo ndi makonzedwe

Mkati Kamodzi patsiku, m'mawa, osatafuna komanso kumwa madzi ambiri (kapu yamadzi). Mankhwalawa atha kumwa onse pamimba yopanda kanthu ndikudya.

Mlingo umayikidwa aliyense payekha, kutengera kulolera ndi kuthekera kwachipatala. Mlingo woyambira wabwino ndi 10 mg / tsiku. Ngati mkati mwa masabata 4 kuyambira chiyambi cha chithandizo, kuchepa kwa thupi lochepera 2 kg kumakwaniritsidwa, ndiye kuti mlingo umakwera mpaka 15 mg / tsiku.

Chithandizo cha Reduxin ® sichiyenera kupitilira miyezi yopitilira 3 kwa odwala omwe satsatira bwino chithandizo, i.e. omwe mkati mwa miyezi itatu yamankhwala amalephera kukwaniritsa kuchepa kwa thupi ndi 5% kuchokera pachizindikiro choyambirira. Kuchiza sikuyenera kupitilizidwa ngati, pogwiritsa ntchito mankhwala ena pambuyo pakuchepa kwa thupi, thupi la wodwalayo limawonjezeka ndi 3 kg kapena kuposa.

Kutalika kwa mankhwalawa sikuyenera kupitilira chaka chimodzi, chifukwa nthawi yayitali mukamamwa mankhwala a sibutramine, kugwiritsa ntchito bwino komanso chitetezo sichimapezeka.

Kuchiza ndi Reduxine ® kuyenera kuchitika molumikizana ndi zakudya ndikuchita masewera olimbitsa thupi moyang'aniridwa ndi adokotala odziwa ntchito yothana ndi kunenepa kwambiri.

Bongo

Zizindikiro Pali umboni wochepa kwambiri wokhudza bongo wa sibutramine. Nthawi zambiri zoyipa zimakhudzana ndi bongo ndi tachycardia, kuthamanga kwa magazi, kupweteka mutu, chizungulire. Wodwalayo adziwitse athandizi awo ngati atayikiridwa mankhwala osokoneza bongo.

Chithandizo: Palibe chithandizo chamankhwala kapena mankhwala enaake. Ndikofunikira kuchita zambiri: kuonetsetsa kuti kupuma mwaulere, kuwunika momwe CVS ilili, komanso, ngati pakufunika kutero, chithandizireni. Kuyendetsa kwakanthawi kaboni wothandiziridwa, komanso kupukusa kwam'mimba, kumachepetsa kudya kwa sibutramine m'thupi. Odwala omwe ali ndi kuthamanga kwa magazi ndi tachycardia adayikidwa beta-blockers. Mphamvu ya kukakamiza diuresis kapena hemodialysis sinakhazikitsidwe.

Malangizo apadera

Kuchiza ndi Reduxine ® kuyenera kuchitika monga gawo la zovuta mankhwala ochepetsa kuwongolera moyang'aniridwa ndi adokotala odziwa ntchito yochizira kunenepa.

Therapy yovuta imaphatikizapo kusintha kwa zakudya ndi moyo, komanso kuchuluka kwa zolimbitsa thupi.

Chofunikira pakuchiritsira ndikupanga njira zofunikira kuti munthu asinthe kudya ndi chikhalidwe, zomwe ndizofunikira kuti achepetse kuchepetsa thupi ngakhale mankhwala ataletsedwa. Monga gawo la mankhwalawa ndi Reduxin ®, odwala ayenera kusintha momwe amakhalira komanso zizolowezi zawo kuti akamaliza kulandira chithandizo akuwonetsetsa kuti kuchepetsa thupi kwakwaniritsidwa.

Odwala ayenera kumvetsetsa bwino kuti kulephera kutsatira izi kumabweretsa kuwonjezeka kwa thupi ndi kubwereza kwa dokotala.

Odwala omwe akutenga Reduxin ®, ndikofunikira kuyeza kuchuluka kwa kuthamanga kwa magazi ndi kugunda kwa mtima. M'miyezi itatu yoyambirira ya chithandizo, magawo amayenera kuwunikiridwa sabata iliyonse, kenako pamwezi. Ngati pakapita maulendo awiri otsatizana kuwonjezeka kwa kugunda kwa mtima kupuma ≥10 kumenyedwa / mphindi kapena CAD / DBP ≥10 mm Hg wapezeka , muyenera kusiya kulandira chithandizo. Odwala omwe ali ndi matenda oopsa, omwe, motsutsana ndi maziko a antihypertensive chithandizo, kuthamanga kwa magazi ndiwokwera kuposa 145/90 mm Hg. , kuwongolera uku kuyenera kuchitika makamaka mosamala ndipo, ngati kuli kotheka, pakakhala nthawi yayifupi. Odwala omwe kuthamanga kwa magazi kawiri panthawi mobwerezabwereza kuyeza kupitilira kwa 145/90 mm Hg. , chithandizo ndi Reduxine ® iyenera kuletsedwa (onani. "Zotsatira zoyipa").

Odwala omwe ali ndi vuto lagona apnea syndrome, ndikofunikira kuwunika bwino magazi.

Kuwonetsetsa makamaka kumafunikira munthawi yomweyo kugwiritsa ntchito mankhwala omwe amachititsa kuti pakhale nthawi ya QT. Mankhwalawa amaphatikizapo histamine H blockers.₁receptors (astemizole, terfenadine), antiarrhythmic mankhwala omwe amachulukitsa nthawi ya QT (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), gastrointestinal motility stimulator cisapride, pimozide, sertindole ndi tricyclic antidepressants. Izi zikugwiranso ntchito mikhalidwe yomwe ingapangitse kuwonjezereka kwa gawo la QT (hypokalemia ndi hypomagnesemia - onani "Kuchita").

Kutalikirana pakati pakudya kwa MAO zoletsa (kuphatikiza furazolidone, procarbazine, selegiline) ndi mankhwala Reduxin ® ayenera kukhala osachepera milungu iwiri.

Ngakhale palibe kulumikizana komwe kwakhazikitsidwa pakati pa kutenga Reduxin ® ndi chitukuko cha matenda oopsa a pulmonary, komabe, chifukwa chodziwika bwino ndi gulu ili la mankhwalawa, kuwunikira pafupipafupi kuchipatala, chisamaliro chapadera chiyenera kulipidwa pazizindikiro monga dyspnea (kufooka kwa kupuma), kupweteka pachifuwa ndi kutupa kwa miyendo .

Mukadumpha muyezo wa Reduxin ®, simuyenera kumwa mankhwalawa piritsi lotsatira, ndikulimbikitsidwa kuti mupitilize kumwa mankhwalawa malinga ndi dongosolo lomwe mwakhazikitsa.

Kutalika kwa kutenga Reduxin ® sikuyenera kupitilira chaka chimodzi.

Pogwiritsa ntchito sibutramine ndi ma SSRI ena, pamakhala chiopsezo chotulutsa magazi. Odwala omwe akuyembekezeka kukhetsa magazi, komanso kumwa mankhwala omwe amakhudza hemostasis kapena kupatsidwa zinthu za m'magazi, sibutramine iyenera kugwiritsidwa ntchito mosamala.

Ngakhale zambiri zamankhwala zosokoneza bongo za sibutramine sizikupezeka, ziyenera kudziwitsidwa ngati panali milandu yodalira mankhwala m'mbiri ya wodwalayo ndikuwonetsetsa pazovuta zomwe zingachitike.

Sibutramine ndi Mndandanda wazinthu zamphamvu, zovomerezedwa ndi Lamulo la Boma la Russian Federation ya pa Disembala 29, 2007 No. 964.

Zokhudza mphamvu pakutha kuyendetsa magalimoto ndi zida. Kutenga Reduxine ® kumatha kukulepheretsani kuyendetsa galimoto komanso kugwiritsa ntchito makina. Munthawi yogwiritsira ntchito mankhwala Reduxin ®, chisamaliro chimayenera kuthandizidwa poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Wopanga

LLC "Ozone". 445351, Russia, Samara Region, Zhigulevsk, ul. Sand, 11.

Tel./fax: (84862) 3-41-09.

Federal State Unitary Enterprise "Moscow Endocrine Chomera". 109052, Moscow, st. Novokhokhlovskaya, 25.

Tel./fax: (495) 678-00-50 / 911-42-10.

Adilesi ndi nambala yafoni yololezedwa ndi bungwe loyitanirana (zodandaula ndi zodandaula): LLC PROMOMED RUS. 105005, Russia, Moscow, ul. Malaya Pochtovaya, 2/2, p. 1, pom. 1, chipinda 2.

Tele: (495) 640-25-28.

Kuyanjana kwa mankhwala osokoneza bongo

Erythromycin, ketoconazole ndi cyclosporine zimachulukitsa plasma ndende ya sibutramine metabolites ndi kuchuluka kwa mtima komanso kuperewera kwa chipatala mosafunikira.

Phenytoin, rifampicin, phenobarbital, carbamazepine, dexamethasone, ndi macrolide mankhwala othandizira amatha kufulumizitsa Reduxin metabolism.

Pogwiritsa ntchito munthawi yomweyo ndi potent analgesics (pethidine, pentazocine, fentanyl), mankhwala ena ochizira migraine (dihydroergotamine, sumatriptan), mankhwala opatsirana (dextromethorphan) ndi mankhwala ochizira matenda osokoneza bongo, nthawi zina, kukula kwa serotonin syndrome ndikotheka.

Reduxin sichimakhudzanso mphamvu yoletsa kubereka pakamwa.

Ndi makonzedwe a munthawi yomweyo ndi Mowa, kuwonjezeka kwa zotsatira zoyipa sikunadziwike. Komabe, mowa sugwirizana kwathunthu ndi zakudya zomwe zimalimbikitsidwa pakumwa.

Zizindikiro zogwiritsidwa ntchito

Reduxin amatchulidwa kuti achepetse thupi pamaso pazinthu zotsatirazi:

• Kunenepa kwambiri kwamankhwala okhala ndi index ya thupi (BMI) ya 27 kg / m 2 kapena kupitilira apo palinso zinthu zina zowopsa zomwe zimagwirizanitsidwa ndi kunenepa kwambiri (osagwirizana ndi insulin - matenda a shuga a mellitus, dyslipoproteinemia),
• Kunenepa kwamankhwala ndi BMI ya 30 kg / m 2 kapena kupitilira.

Malangizo ogwiritsira ntchito Reduxin: njira ndi mlingo

Reduxin amayenera kumwedwa kamodzi pa tsiku, m'mawa, kumeza makapu athunthu ndikuwamwa ndi madzi okwanira, pamimba yopanda kanthu kapena pakudya.

Mlingo woyambira wabwino ndi 10 mg. Ngati mkati mwa milungu 4 sizingatheke kukwaniritsa kuchepa kwa thupi osachepera 5%, mlingo wa tsiku ndi tsiku umakulitsidwa mpaka 15 mg.

Kutalika konse kwa chithandizo sikuyenera kupitilira zaka 2 (chifukwa cha kusowa kwa chidziwitso pa chitetezo ndi kugwiritsidwa ntchito kwa nthawi yayitali kwa sibutramine).

Ngati mkati mwa miyezi itatu palibe kuchepa kwa thupi ndi osachepera 5% ya kulemera koyamba, Reduxine imachotsedwa. Kuchiza sikuyenera kupitilizidwa ngati, ndi mankhwala ena othandizira, wodwalayo amawonjezeranso 3 kg kapena kuposerapo.