Malingaliro a Dr. Myasnikov pa chithandizo cha cholesterol yayikulu

Lingaliro lodziwika kuti cholesterol ndi zovulaza thanzi silikugwirizana kwenikweni ndi zenizeni. M'malo mwake, ndikofunikira kuonetsetsa njira zina zofunika mthupi.

Pafupifupi 20% yokha ya chinthu ichi chimabwera ndi chakudya, ndipo 80% amapanga chiwindi. Chokondweretsa ndichakuti lingaliro la dotolo wodziwika komanso wowonetsa pulogalamu yodziwika bwino ya udokotala, a Dr. Myasnikov, pa cholesterol ndi ma statins. Amadziwika kuti iye mwini amatenga mankhwalawa kwa nthawi yayitali kuti ateteze matenda a atherosulinosis.

Maganizo okhudza vuto la dokotala wotchuka

Thupi laumunthu limakhala ndi cholesterol yapamwamba komanso yotsika. Zotsirizirazi "sizothandiza," ndipo ndiamene zimayambitsa mapangidwe a atheroscrotic plaque pamitsempha yamagazi ndi mitsempha. Pamlingo wake wokwera, mankhwala ochokera ku gulu la statins ndi omwe amapatsidwa. Awa ndi chithandizo chachikulu chomwe chimagwiritsidwa ntchito pochiza matenda a m'mitsempha.

Amakhulupirira kuti kusiyanitsa zakudya kwawo, kuchuluka kwa cholesterol yotsika m'magazi kumachepera. Cholesterol imakhala ndi cholesterol, yomwe imakhala mbali ya membrane wa cell ndikupatsanso kukana kutentha kwambiri. Kuphatikiza apo, vitamini D, wofunikira pakukula kwakanthawi kwam'mafupa, samapangidwa popanda cholesterol.

A Alexander Myasnikov, dotolo wamkulu wachipatala cha ku Moscow, adalangiza kuwunika zoyipa ndi zopindulitsa za cholesterol m'thupi, kutengera mphamvu ya lipoprotein yomwe imapezeka m'chipangizochi. Dokotala akuwunikira kuti, kawirikawiri, kuchuluka kwa lipids otsika kwambiri komanso okwera ayenera kukhala omwewo.

Ngati zizindikiro za chinthu chokhala ndi kachulukidwe kachuluka kwambiri, ndiye kuti izi ndizofunikira pakapangidwe ka cholesterol polekezera mkati mwa makoma amitsempha yamagazi. Ndipo izi, ndizomwe zimayambira kutenga ma statins. Dr. Myasnikov akuwonetsa kuti njira zoterezi zimapangika mwachangu pansi pa zochitika zotsatirazi:

• matenda ashuga
• kuthamanga kwa magazi
• kunenepa
• matenda a mtima
• kusuta
• kuzunza mafuta.

Komanso, Dr. Myasnikov amalankhula za kuvulala kwapadera kwa cholesterol kwa azimayi omwe ali ndi nyengo ya postmenopausal. Ngati mpaka nthawi ino kuchuluka kwamphamvu ya mahomoni ogonana achikazi otetezedwa ku chitukuko cha atherosulinosis, ndiye kuti kusiya kusintha kwa mapangidwe awo kumachepetsedwa, zomwe zikutanthauza kuti chiopsezo chokhala ndi matendawa chikuwonjezeka. Poterepa, adotolo akuwunikira kuti cholesterol ndiyofunikira kwa thupi, chifukwa ndichoofunikira kwambiri pakupanga mahomoni onse.

Kusowa kwa ziwopsezo ndi kukwera moyenera kwa cholesterol sikufuna mankhwala. Mabuluzi akuwonetsa kuti kuikidwa kwawo kuli koyenera pamaso pa matenda kapena pamene wodwala ali ndi kuphatikiza pazinthu zingapo zowopsa. Izi ndi, mwachitsanzo, ngati wodwala yemwe amasuta matenda oopsa amakhala ndi cholesterol yokwanira, pomwe amakhalanso ndi matenda a shuga.

Monga akatswiri ena pantchitoyi, Dr. Myasnikov akuti ngakhale mwa anthu omwe amangodya zakudya zokhazokha, cholesterol yawo imatha kukwezedwa. Izi zikufotokozedwa ndi cholowa chamtsogolo, zovuta za metabolic, kupezeka kwa zizolowezi zoipa, moyo wokhazikika.

Kodi ma statins ndi ati?

Statins ndi lipid-kuchepetsa mankhwala omwe amaletsa kupanga enzyme yomwe imakhudzidwa ndi kapangidwe ka cholesterol ndi maselo a chiwindi.Kukonzekera kwa izi kumathandizira kuti mawonekedwe amitsempha yamagazi awonongeke panthawi yomwe sikutheka kuzindikira atherosulinosis, koma mawonekedwe a cholesterol ayamba kale kukhoma lamkati.

Ino ndi gawo loyambirira pakukula kwa atherosulinosis. Kuphatikiza apo, akatswiri amawona phindu la ma statins pazinthu zamagazi, makamaka, mamvekedwe ake amachepa. Izi, zimalepheretsa mapangidwe azigazi komanso zimalepheretsa kudziphatika kwawo ku cholesterol plaque. Pali mibadwo 4 ya ma statins. Muzochita zamankhwala, mankhwala a m'badwo woyamba amakhala ochulukirapo.

Zinthu zogwira ntchito mwa iwo ndi lovastatin, pravastatin, rosuvastatin. Mankhwalawa ndi ochokera ku chilengedwe, koma izi sizabwino, chifukwa sizothandiza kwenikweni ndipo zimakhala ndi zovuta zingapo. Amakhalanso ndi mtengo wotsika. Izi zikuphatikizapo Cardiostatin, Sinkard, Zokor, Vasilip, Holetar.

Ma statin a m'badwo wachiwiri samakhala ndi mphamvu kwambiri pamthupi ndipo amakhala ndi mphamvu yayitali. Mankhwala a m'badwo uno ndi Leskol Forte ndi yogwira mankhwala fluvastatin. Amatsitsa cholesterol osaposa 30%. Mbadwo wachitatu wama statins wozikidwa pa atorvastatin (Tulip, Atomax, Liprimar, Torvakard) amakhala ndi zovuta:

• cholesterol wotsika wotsika kwambiri,
• chepetsa kupanga triglyceride,
• kumapangitsa kukula kwa mkulu osalimba lipids.

Zothandiza kwambiri ndi ma statins a m'badwo wotsiriza, wachinayi. Ubwino wawo ndikuti samathandizira kuchepetsa cholesterol yoyipa, komanso kuwonjezera cholesterol yapamwamba. Mbadwo waposachedwa wa statins ndi rosuvastatin. Komabe, osavomerezeka kwa anthu omwe ali ndi matenda a impso. Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumatha kuyambitsa matenda a shuga.

Kuphatikiza pa izi, zotsatirazi zikuyembekezeka kuchokera ku ma statins:

• kutsika kwa kuchuluka kwa zolembedwa zam'madzi,
• kuponderezana kwa minofu ya mtima,
• odana ndi yotupa mphamvu ya magazi.

Momwe milandu amaikidwira

Zizindikiro zoika ma statins zimaphatikizidwa m'magulu awiri: mwamtheradi komanso wachibale. Mtheradi amati kuvomerezedwa kwa kugwiritsa ntchito mankhwalawa kuteteza matenda ake. Mikhalidwe yothandizirana imaphatikizapo pamene mankhwalawa amatha kusinthidwa ndimankhwala ena kapena mankhwala azakudya. Kwa magulu ena a odwala, kukana kudya ma statins kumatha kubweretsa zovuta zazikulu komanso kufa.

Zizindikiro Zathunthu ndizophatikiza:

• cholesterol imaposa 10 mmol / l,
• hypercholesterolemia wolimba pambuyo miyezi itatu yamankhwala
• tsogolo la banja kuti liwonjezere kupangika kwa lipoproteins otsika,
• kukhalapo kwa zizindikiro zazikulu za atherosulinosis,
• kuphwanya lipid kagayidwe,
• matenda a mtima oopsa omwe ali ndi chiopsezo chachikulu cha matenda a mtima komanso sitiroko,
• abortinal aortic aneurysm,
• matenda am'mitsempha
• matenda a shuga ophatikizika ndi matenda a mtima,
• mbiri ya matenda opha ziwalo kapena matenda a mtima.

Chizindikiro chotsimikizika pakusankhidwa kwa mankhwalawa ndi cholesterol yamagazi yowonjezereka, ngati chiwonetsero chonse chikuposa 6 mmol / L, ndi lipoproteins otsika - oposa 3 mmol / L. Komabe, kuikidwa kwa ma statins ndi munthu mwachilengedwe. Chifukwa chake, nthawi zina, mumayenera kutenga ma statins pamtengo wotsika, koma pali zinthu zambiri zowopsa.

Kugwirizana kwa mawonetsero kumatanthauza kuti ndikofunikira kumwa ma statins, koma simungayesere kugwiritsa ntchito mankhwala, koma mankhwala othandizira. Malingaliro omwewo amagwiritsidwa ntchito mu milandu yotsatirayi:

• mbiri ya angina wosakhazikika,
• kumwalira mwadzidzidzi wachibale wapamtima wazaka zosaposa 50 chifukwa cha matenda a mtima,
• chiopsezo chochepa cha matenda amtima,
• matenda ashuga
• kunenepa
• kukwaniritsa kwa zaka 40 ndi chiopsezo chomwe chikukula kwa matenda a mtima.

Malinga ndi miyezo wamba, cholesterol yayikulu, koma kusakhala pachiwopsezo cha kukhala ndi mtima wamtima sizikhala chokwanira pakuyika ma statins. Koma kuthekera kwa kumwa mankhwalawa kumawunikiridwa ndi dokotala aliyense payekhapayekha, poganizira matenda omwe ali ndi matenda obadwa nawo.

Ndi dokotala yekhayo amene amawerengetsa omwe wodwala angatenge ndipo ayenera kumwa. Lingaliro la adokotala Myasnikov ponena za kuperekedwa kwa ma statins ndi motere: kukhalapo kwa zinthu zoopsa, mwachitsanzo, kunenepa kwambiri komanso matenda osokoneza bongo, ndi cholesterol ya 5.5 mmol / l ndiye maziko a kudya kwawo.

Contraindication ndi zotheka kuvulaza

Funso lokhudza maubwino ndi zovulaza za ma statins lidakalipobe ndipo likuyambitsa mikangano yambiri. Ngakhale kuti mankhwalawa ndi othandiza kwambiri kuchepetsa kuthana kwa cholesterol yochepa, mankhwalawa amatha kuyambitsa mavuto. Dr. Myasnikov akutsimikiziranso izi, ndipo sizokayikitsa kuti pakhale katswiri yemwe anganene motsutsa izi. Choyamba, mankhwalawa amakhudza chiwindi.

Kuwerengera molakwika kwa kuchuluka kwa ma statins kungayambitse kusakonzekera kosafunikira. Nthawi zambiri, mankhwala osokoneza bongo amayamba chifukwa cha kupezeka kwa dyspeptic phenomena, makamaka, wodwalayo amakhala ndi mseru, amachepetsa kapena alibe, kugaya chakudya kumasokonezeka. Potere, kuchepetsa kuchuluka kwa mankhwalawa kungathandize kupirira nawo.

Kodi cholesterol ndi chiyani ndipo chifukwa chiyani ingakhale yoopsa

Cholesterol ndi zovuta bile kapena lipophilic mowa. Achilengedwe pawiri ndi gawo limodzi mwa nembanemba am'm cell, zomwe zimapangitsa kuti azigwirizana kwambiri ndikusintha kwa kutentha. Popanda cholesterol, kupanga mavitamini D, ma acid a bile ndi mahomoni a adrenal ndikosatheka.

Pafupifupi 80% ya zinthu zomwe thupi la munthu limadzipanga zokha, makamaka m'chiwindi. 20% yotsala ya cholesterol imabwera ndi chakudya.

Cholesterol imatha kukhala yabwino komanso yoyipa. Dokotala wamkulu wa State Clinical Hospital No. 71 Alexander Myasnikov akuwonetsa chidwi cha odwala ake kuti chidziwitso chothandiza kapena chosasangalatsa m'thupi la chinthu chimadalira kuwuma kwa lipoproteins omwe amapanga organic piritsi.

Mwa munthu wathanzi, kuchuluka kwa LDL mpaka LDL kuyenera kukhala kofanana. Koma ngati zisonyezo za ma lipoprotein otsika kwambiri zimachulukira, zotsalazo zimayamba kukhazikika pamakoma a zotengera, zomwe zimayambitsa mavuto.

Dokotala wa Myasnikov akuti kuchuluka kwa cholesterol yoyipa kumachuluka makamaka ngati pali zinthu zotsatirazi zoopsa:

1. matenda ashuga
2. matenda oopsa
3. onenepa kwambiri
4. kusuta
5. Matenda a mtima wa Ischemic,
6. kuperewera kwa zakudya m'thupi
7. atherosulinosis yamitsempha yamagazi.

Chifukwa chake, chifukwa choyambirira cha kukhwimitsa kwa stroko ndi kugunda kwa mtima kuzungulira padziko lonse lapansi ndikuwonjezereka kwa cholesterol yoyipa m'magazi. LDL imayikidwa pamatumbo, ndikupanga zolembera za atherosselotic, zomwe zimathandizira kuwoneka kwa ziwalo zamagazi, zomwe nthawi zambiri zimabweretsa kufa.

Butcher imalankhulanso za cholesterol ya azimayi, yomwe imakhala yoyipa kwambiri pambuyo kusamba. Inde, asanasiye, kupangika kwama mahomoni ogonana kumateteza thupi ku mawonekedwe a atherosulinosis.

Ndi cholesterol yayikulu komanso zoopsa zochepa, mankhwalawa saikidwa mankhwala.

Komabe, adokotala akukhulupirira kuti ngati wodwalayo ali ndi cholesterol osapitirira 5.5 mmol / l, koma nthawi yomweyo pali zoopsa (kuchuluka kwa shuga m'magazi, kunenepa kwambiri), ndiye kuti ma statins ayenera kumwedwa.

Zizindikiro za hypercholesterolemia

Statins ndi gulu lotsogoza la mankhwala omwe amachepetsa cholesterol yoyipa kukhala yovomerezeka.Mankhwalawa amachepetsa kwambiri mwayi wokhala ndi matenda amtima, ngakhale Dr. Myasnikov amayang'ana odwala kuti mfundo yeniyeni yochita zawo sichidziwika ngati mankhwala.

Dzina lasayansi la statins ndi HMG-CoA reductase inhibitors. Ndi gulu latsopano la mankhwala omwe amatha kutsitsa LDL mwachangu ndikukulitsa chiyembekezo chamoyo.

Mwina, statin imachepetsa kugwira ntchito kwa hepatic cholesterol yomwe imapanga. Mankhwalawa amawonjezera kuchuluka kwa LDL-receptors of apoliprotein ndi HDL muma cell. Chifukwa cha izi, cholesterol yovulala imatsalira kumbuyo kwa makoma a mtima ndipo imagwiritsidwa ntchito.

Dr. Myasnikov akudziwa zambiri za cholesterol ndi ma statin, popeza akhala akuwatenga kwa zaka zambiri. Dotoloyo akuti kuphatikiza ndi zotsatira za kuchepa kwa lipid, ma inhibitors amtundu wa chiwindi ndiwofunika kwambiri chifukwa chothandiza pamitsempha yamagazi:

• khazikitsani mapepala, kuchepetsa mwayi wophulika
• Chotsani zotupa m'mitsempha,
• khalani ndi anti-ischemic zotsatira,
• Sinthani microsolysis,
• limbitsa mtima epithelium,
• kukhala ndi antiplatelet.

Kuphatikiza pa kuchepetsa mwayi wokhala ndi matenda amtima wamagazi, kugwiritsa ntchito ma statins ndikupewa kupezeka kwa mafupa ndi khansa ya m'matumbo. HMG-CoA reductase inhibitors imalepheretsa mapangidwe a gallstones, matenda a impso.

Dokotala wa Myasnikov amatengera chidwi chakuti ma statins ndi othandiza kwambiri kwa abambo. Mankhwala osokoneza bongo amathandizira kusokonekera kwa erectile.

Ma statin onse amapezeka mu mawonekedwe a mapiritsi. Phwando lawo limachitika kamodzi patsiku pogona.

Koma musanamwe ma statins, muyenera kumwa mkodzo, kuyezetsa magazi ndikupanga mbiri ya lipid yomwe imawulula zakuphwanya kwa metabolism yamafuta. M'mitundu yoopsa ya hypercholesterolemia, ma statin adzafunika kuledzera kwa zaka zingapo kapena moyo wonse.

Inhibitors a chiwindi enzyme amadziwika ndi mankhwala zikuchokera ndi m'badwo:

Ngakhale kuphatikiza kwakukulu kwa ma statins mu hypercholesterolemia, Dr. Myasnikov akuwonetsa mwayi wokhala ndi zotsatirapo zoipa mutawatenga. Choyamba, mankhwalawa amakhudza chiwindi.

Amakhulupirira kuti ma statins amawonjezera chiopsezo cha matenda amtundu wa 2. Komabe, Myasnikov akukhulupirira kuti ngati mutatenga mapiritsiwo muyeso wamba, ndiye kuti kuchuluka kwa glucose kumakwera pang'ono pokha. Komanso, kwa odwala matenda ashuga, matenda a m'matumbo, omwe amakhala ndi matenda a mtima komanso stroko, owopsa kuposa kuphwanya pang'ono kagayidwe kazakudya.

Kafukufuku wambiri adatsimikizira kuti nthawi zina, ma statin amasokoneza kukumbukira komanso amatha kusintha machitidwe a anthu. Chifukwa chake, ngati mutatha kutenga ma statins zoterezi zimachitika, muyenera kufunsa dokotala yemwe angasinthe kapena kusiya kugwiritsa ntchito mankhwalawa.

Nthawi yomweyo, Alexander Myasnikov amalimbikitsa kuti odwala omwe, pazifukwa zina, sangathe kuthandizidwa ndi ma statins, m'malo mwake ndi Aspirin.

Ma statin achilengedwe

Kwa anthu omwe sakhala pachiwopsezo, omwe cholesterol imachulukitsidwa pang'ono, Myasnikov amalimbikitsa kuchepetsa zomwe zili ndi mafuta m'magazi mwachilengedwe. Sinthani mulingo wa LDL ndi HDL ndi chithandizo cha zakudya.

Choyamba, adokotala amalimbikitsa kudya mtedza, makamaka ma amondi. Zimatsimikiziridwa kuti ngati mumadya pafupifupi 70 g ya mankhwala tsiku lililonse, ndiye kuti thupi lidzakhalanso ndi zofanana pochiritsa pambuyo poti mutenge ma statins.

A Alexander Myasnikov amalimbikitsanso kudya zakudya zam'madzi kangapo pa sabata. Koma kuchuluka kwa mafuta, nyama yofiira, soseji ndi ma offal kuyenera kukhala kochepa.

Polankhula za cholesterol yayikulu, Dr. Myasnikov amalimbikitsa kuti odwala ake asinthe mafuta a nyama ndi mafuta azomera. Zosakhazikika zopendekera, zitsulo kapena mafuta a azitona, zomwe zimalimbitsa mtima makoma, ndizothandiza kwambiri kwa thupi.

Kwa anthu onse omwe ali ndi vuto la hypercholesterolemia, a Alexander Leonidovich alangiza kuti azidya zinthu zopatsa mkaka tsiku lililonse. Chifukwa chake, yogurt yachilengedwe imakhala ndi sterol, yomwe imatsitsa cholesterol yoyipa ndi 7-10%.

Ndikofunikanso kudya masamba ndi zipatso zambiri zomwe zimakhala ndi fiber. Utoto wolimba umamanga ndikuchotsa LDL mthupi.

Mu kanema mu nkhaniyi, Dr. Myasnikov amalankhula za cholesterol yayikulu.

Alexander Myasnikov ndi ndani

Alexander Leonidovich Myasnikov anabadwira ku banja la madotolo olowa m'malo ndipo adalandira maphunziro ku N.I. Pirogov Medical Institute. Kenako adamaliza sukulu yomaliza ndikuteteza lingaliro lake laudindo wa munthu amene adzalembetse maphunziro azachipatala. Dr. Myasnikov ndi katswiri wamtima ndi katswiri wamkulu. M'mzaka zosiyanasiyana za moyo wake adapita ku US, France, ndi mayiko ena a ku Africa.

Lero, Alexander akutsogolera chipatala chazachipatala chotchedwa M.E. Zhadkevich ku Moscow. Ndipo amayendetsa pulogalamu "Pa chofunikira kwambiri" ndipo nthawi zambiri amalankhula pa wailesi, akulankhula momveka bwino za matenda omwe ali ponseponse masiku ano.

Lingaliro la Dr. Myasnikov pa cholesterol yayikulu

Matenda amtima ukadali pamalo oyamba padziko lapansi monga chitsogozo chachikulu cha imfa. Chifukwa chake, ndikofunikira kulabadira cholesterol yokwezeka, yomwe ndi harbinger wa atherosulinosis ndi matenda a mtima, amatero Dr. Myasnikov. Wasayansi waku Russia Nikolai Nikolaevich Anichkov anali m'modzi mwa oyamba kutsimikizira kulumikizana kwa cholesterol yayikulu komanso kupezeka kwa matenda atherosclerotic. Iye ndi mlembi wazithunzi zambiri zomwe zimagwiritsidwa ntchito pochiritsira chamakono cha cholesterol yapamwamba.

Dr. Myasnikov amalankhula zakuti pafupifupi 80% ya cholesterol imapangidwa m'thupi la munthu, ndipo timangopeza 20% kuchokera ku chakudya. Cholesterol imagawidwanso kukhala "yoyipa" ndi "yabwino", LDL ndi HDL, motsatana. Ma lipoproteins otsika kwambiri amatha kukhazikika pamtundu wa mitsempha ndikukula mu epithelium yamitsempha, ndikupanga lipidini. Koma lipoprotein yapamwamba kwambiri, m'malo mwake, imatha kuthana ndi kukonzekera kwa LDL m'mitsempha yamagazi ndikuyendetsa cholesterol yoyipa molunjika ku chiwindi kuti iwonongeke kwambiri mu hepatocytes.

Dokotala wa Myasnikov akuti zisonyezo za cholesterol yoyipa, mwanjira ina, lipoproteins yotsika, pamodzi ndi triglycerides iyenera kukhala yotsika. Nthawi yomweyo, mulingo wa milingo yapamwamba kwambiri uyenera kukhala wokwera. Kuphatikizika uku komwe kukuwonetsa kuthekera kotsika kwa kufa chifukwa cha kuphedwa kwa myocardial m'zaka khumi zikubwerazi, malinga ndi kuchuluka komwe kungachitike pakukula kwa njira iyi.

Adokotala a Myasnikov akufotokozera, pogwiritsa ntchito chitsanzo cha asodzi a Yakut omwe amedza nsomba zochuluka ndi caviar, kuti nthawi zambiri cholesterol yayikulu imalumikizidwa ndi kudya nyama. Popeza pakati pa anthuwa, modabwitsa ndizovuta zamtima ndi mtima zomwe zimapezeka.Makonda a malonda m'zaka zaposachedwa ndikutsimikiza kwazinthu zonse. Koma katswiri wamtima wamtundu wa Myasnikov amakhulupirira kuti kukana kwathunthu mafuta mu chakudya sikuyenda bwino. Popeza kuti thupi lonse limagwira, ndikofunikira kudya zakudya ndi mafuta m'thupi. Ndi chenjezo limodzi - kudya mafuta kuyenera kukhala koyenera komanso kovomerezeka.

A Alexander Leonidovich akuganiza kuti chophweka ngati mtedza (makamaka ma amondi) chogwiritsidwa ntchito tsiku lililonse chimachepetsa kwambiri lipids yamagazi. Malinga ndi zofalitsa zaku America zamankhwala, ndikofunikira kudya pafupifupi 70 magalamu a mtedza popewa hypercholesterolemia.

Mu gawo lina la telecast yake, cardiologist Myasnikov adalankhula mwatsatanetsatane za cholesterol ya azimayi, bwanji samakonda kwambiri hypercholesterolemia. Chilichonse ndichopepuka kwambiri - mahomoni ogonana achikazi amateteza thupi kuti lisachulukane kwambiri ndi lipids m'magazi. Ndipo pokhapokha atayamba kusamba (zaka 45-50) mwa akazi, chiopsezo cha hyperlipidemia chimawonjezeka. Ndi nthawi imeneyi pomwe Dr. Myasnikov amalimbikitsa azimayi kuti azikhala ndi chidwi ndi zomwe zili ndi lipid.

Mabatani amatenga ma statins

A Alexander Leonidovich Myasnikov amalankhula kuti lero ma statins akhala mankhwala ogulitsa kwambiri padziko lapansi. Osati kale kwambiri, gulu lonse la asayansi linavomereza kuti kugwiritsa ntchito ma statin, ngakhale ndi cholesterol yokwezeka pang'ono, kumachepetsa kwambiri kufa kwa matenda a mtima. Mankhwala amakono, anti-atherogenic magulu a mankhwala amaperekedwa pokhapokha ngati pali zina zomwe zikukulitsa kuphatikiza cholesterol yayikulu.

Dr. Myasnikov ali ndi nkhawa kuti nthawi zambiri anthu amamwa mankhwala a cholesterol mosaganizira komanso popanda mankhwala. Ubwino wa ma statins ndikuletsa kupitirira kwa matenda a atherosulinotic ngati pali njira zina zodziwika bwino. Mavuto a statins amaphatikizapo kuthekera kwa matenda ashuga, kapamba, hepatitis. Kugwiritsidwa ntchito kosalamulirika kwa ma statins kungayambitse kuchepa kwa chitetezo chamthupi pang'onopang'ono. Popeza kupangika kwa chitetezo cha mthupi kumalepheretsa. Chifukwa chake popanda dokotala, muyenera kugwiritsa ntchito mapiritsi awa.

Zizindikiro zokwanira zama statins ndizokwera kwambiri kwa cholesterol (> 9 mmol / L). Nthawi zina, mwachitsanzo, ngati cholesterol yanu imangochulukirapo pang'ono pazovomerezeka popanda ma concomitant pathologies, ma statins safunika. Ndikokwanira kusintha kadyedwe ndi kagwiritsidwe kake kokwanira, atero Dr. Myasnikov.

Ma cholesterol okwera moyenera omwe ali ndi ma pathologies osakhalapo komanso zinthu zoopsa sizomwe zikuwonetsa mwachindunji kuti atenge ma statins, wokhulupirira zamtima amakhulupirira. Kupereka ma statins, kuphatikiza kwa zinthu zingapo ndikofunikira, mwachitsanzo:

• Kusuta.
• Kuthamanga kwa magazi.
• Hyperglycemia.
• Kunenepa kwambiri.
• Amuna kapena akazi
• Wophedwa ndi cholowa.
• Kupezeka kwa matenda a mtima.

Ndi kuphatikiza kwa zinthu zambiri zomwe zimakhudza atherosulinosis, dokotala amatulutsa dongosolo la mankhwala a statin. Popeza kwa odwala omwe ali pachiwopsezo, mankhwala a anti-atherogenic osakanikirana ndi zakudya amachepetsa chiwopsezo cha kugwa kwamitsempha, ischemia ya minofu ya mtima, ndi mitsempha yodutsika yam'munsi.

Dr. Myasnikov ndi gawo la njira yophatikizira yochizira cholesterol yapamwamba. Asanapange njira yothandizira anti-atherogenic mankhwala, dokotala woyenera ayenera kudziwa momwe thupi la wodwalayo limakhudzidwira ndi zomwe zimagwirizana ndi zina zake. Alexander Leonidovich amakumbukiranso kufunikira kwa zakudya zoyenera zomwe zimakhala ndi mapuloteni, mafuta komanso chakudya chamagulu ambiri.

Adokotala akuba za dokotala za ma statins a cholesterol maubwino ndi zoyipa - About cholesterol

Kukula kofala kwa atherosulinosis ndi matenda okhudzana ndi (matenda a mtima, matenda amitsempha, kulowetsedwa kwamatenda am'munsi) zapangitsa kuti ma statins agwiritsidwe ntchito pafupipafupi kuti apeze anticholesterol. Komabe, ngakhale gululi limagwira bwino ntchito, sikulimbikitsidwa kuti mupereke kwa wodwala aliyense. Pali zifukwa zingapo izi: zoyipa za ma statins pa chiwindi, ziwalo zina za thupi, komanso kusamvetseka kwazomwe amagwiritsidwa ntchito muzochitika zina zamankhwala. Ubwino ndi zovuta za ma statins kwa wodwala wina ziyenera kumawunikidwa nthawi zonse ndi dokotala musanapange mankhwala.

• About cholesterol
• About ma statins
• Zovulala pakutenga ma statins
• Mukamagwiritsa ntchito chiyani?

Atherosulinosis imagwirizana kwambiri ndi cholesterol yokwezeka, chifukwa chake, anthu ambiri amagwirizana ndi mankhwala. Choyambirira, cholesterol ndi lipid yofunikira kwa thupi, yomwe imagwira ntchito yofunika kwambiri pakumanga ndi kusunga umphumphu wama membrane wamaselo, komanso kutenga nawo gawo pakuphatikizidwa kwamahomoni osiyanasiyana mthupi.

Cholesterol ndi lipid yofunika kwambiri m'thupi la munthu, kutenga nawo mbali machitidwe a kagayidwe kake ndikupanga zinthu zambiri zofunika.

Kunena kuti "cholesterol yoyipa" iyenera kuzindikirika ngati milingo yochepa ya ma cell lipoproteins (LDL) - mafuta owonjezera mapuloteni omwe amayenda ndi cholesterol ku chiwindi kupita ku ziwalo zosiyanasiyana kudzera m'mitsempha yamagazi. Ndiye kuwonjezeka kwa LDL komwe kumavulaza khoma lakuthwa ndikuwopseza chitukuko cha malo a atherosulinotic. Kenako, ma lipoproteins okwera kwambiri (HDL) amatenga mbali yotsutsana - amatenga mafuta m'thupi ndi mafuta ena kuchokera kumakoma amitsempha yamagazi ndi ziwalo kupita ku chiwindi, komwe lipids imasinthidwa kukhala mamolekyulu ofunikira. Pankhaniyi, HDL imateteza thupi ku mawonekedwe a atherosulinosis m'matumbo.

Chifukwa chake, kuwerengetsa kwa kuchuluka kwa cholesterol kokha pakuwunika magazi mosiyanasiyana sikungapereke chidziwitso chambiri chokhudza matenda a lipid metabolism mthupi. Ndikulimbikitsidwa kuyeza onse muyeso wa cholesterol, komanso kuchuluka kwa LDL ndi HDL mu plasma.

About ma statins

Ma Statins, ndi chiyani? Ndi mankhwala omwe amagwiritsidwa ntchito kwambiri ngati mankhwala kutsitsa cholesterol yamagazi ndi LDL. Mphamvu ya ma statins imachitika pamlingo wamaselo a chiwindi, komwe ma cholesterol ambiri mthupi la munthu amapangidwa. Kutenga mankhwala alionse kuchokera ku gulu la ma statins, munthu amatchinga ma enzyme ofunika mu kapangidwe ka cholesterol ndipo potero amachepetsa kuchuluka kwake m'magazi. Nthawi yomweyo, mankhwalawa amaikidwa ngati mankhwala abwino kwambiri omwe amapezeka, komabe, ndikofunikira kukumbukira nthawi zonse kuti pali zabwino komanso zovulaza.

Nthawi yomweyo, pali mndandanda wazowonetsa momwe ayenera kumwa ndi odwala omwe ali ndi matenda ena kapena chiwopsezo cha kukula kwawo:

• Kupanga ma statins kumawonetsedwa kwa anthu omwe ali pachiwopsezo chachikulu chokhala ndi myocardial infarction, makamaka okhala ndi LDL komanso cholesterol yambiri m'magazi. Monga lamulo, muzochitika zoterezi, sizotheka kukwaniritsa kuchepa kokwanira pamlingo wa lipids izi pokhapokha pakusintha moyo kapena zakudya. Chifukwa chake, kumwa ma statins munkhaniyi ndikofunikira.
• Mankhwala a gululi ndi oyenera kupewa matenda a ischemic stroke mwa anthu omwe ali ndi LDL ndi cholesterol yambiri, komanso osathanso kudzudzulidwa pogwiritsa ntchito njira zosagwiritsa ntchito mankhwala.
• Nthawi ya infaration nthawi yayitali ndikuwonetsa mwachindunji kugwiritsidwa ntchito kwa ma statins, makamaka koyambirira pambuyo pakuwonongeka kwa myocardial. Ndikofunikira kusankha mlingo woyenera wowonetsetsa kuti mankhwala azithandizira pakukonzanso.
• Hyperlipidemia (kuwonjezereka kwa lipids m'magazi) mwa wodwala kumakhala chizindikiro cha kuperekedwa kwa ma statins.

Munthawi zonsezi, funso loti azimwa kapena osamwa ma statins liyenera kusankhidwa ndi adokotala, atawunika wodwalayo ndi njira zina zowonjezera zofufuzira. Kusankhidwa kwawo kumatha kubweretsa zovuta zingapo zoyipa.

Kugwiritsa ntchito ma statins osankhidwa pawokha kungachepetse chiopsezo cha mavuto.

Zambiri za mibadwo ingapo ndizopadera:

• Mankhwala ochokera m'badwo woyamba (Rosuvastatin, Lovastatin, etc.) amakhala ambiri machitidwe azachipatala. Koma ndizotsatira zawo zomwe ndizofala kwambiri,
• Mankhwala a m'badwo wachiwiri (fluvastatin) amagwirizanitsidwa ndi chiopsezo chochepa cha zotsatira zosafunikira za mankhwala,
• M'badwo wachitatu wama statins (Atoris, Amvastan, Atorvastatin) amagwiritsidwa ntchito ngati othandizira a prophylactic,
• M'badwo wachinayi wa statins (Crestor, Rosart) ndi njira zabwino kwambiri. Zotsatira zawo sizimangoletsa kuchepa kwa cholesterol ndi LDL, komanso zimatha kukhudza zolembedwa za atherosulinotic ndikuziwononga.

Kusankhidwa kwa mtundu wapadera wa statin kumadalira matenda a wodwala, mbiri yachipatala komanso lingaliro la adotolo.

Zovulala pakutenga ma statins

Kulemba molakwika kwa ma statins, cholakwika pakuwerengedwa kwa mankhwalawa, kumatha kuyambitsa zovuta zosiyanasiyana zamankhwala zosokoneza bongo, zomwe zingakhudze thanzi la munthu komanso matendawo chifukwa cha chithandizo. Kufufuza bwino wodwalayo, komanso kuwerengera matenda ophatikizika, kumakupatsani mwayi kuti musachite mantha ndi ma statins akapatsidwa mankhwala. Chifukwa chiyani ma statin ndi oopsa?

• Chimodzi mwazinthu zoyipa ndizotsatira za dyspeptic dalili - nseru, kuchepa kapena kusowa kudya, kugaya chakudya ndi kuwonongeka kwa m'mimba kapena kudzimbidwa. Monga lamulo, kuchepetsa mlingo wa mankhwala mutha kuthana ndi mavuto.
• Kugwira ntchito kwamanjenje kumasokonezeka - kusinthasintha kwa mtima kumachitika ndi kupsinjika, kusokonezeka kwa tulo monga kusowa tulo, kusowa kukumbukira kwakanthawi kochepa ndi ntchito zina zazidziwitso.
• Matenda ndi chiwindi ndizogwirizana chifukwa cha mapangidwe ake a mankhwala. Chifukwa chake, kukulitsa kwa chiwindi, komanso kapamba kuchokera ku ma statins, ndizotheka. Kuwonongeka kwa chiwindi kumayambitsa kukula kwa ululu mu hypochondrium yoyenera, nseru, mwina kuchuluka kwa micirubin ndi michere ya chiwindi pakuwunika kwa magazi.
• Amuna atha kukhala ndi kuphwanya chilakolako chogonana, kusowa mphamvu pokhudzana ndi kuphwanya kapangidwe ka mahomoni ogonana amuna.

• Vuto lodziwika kuchokera ku ma statins ndikuwoneka kwa kupweteka kwa minofu ndi kuphatikizika, zomwe zimagwirizanitsidwa ndi kuphwanya kwa metabolic mu minofu minofu.
• Kuphatikiza pazizindikirozi, mphamvu ya mankhwalawa imatha kubweretsa kuwonongeka kwa impso, mandala, zotupa pakhungu, kutupa, kuchuluka kwamagazi, ndi zina zambiri.

Chiwopsezo cha kuwonongeka kwa chiwindi ndi zotsatira zina zimafuna njira mosamala kuti mudziwe njira zamankhwala zochizira hypercholesterolemia mwa wodwala aliyense komanso kusankha kwa mlingo woyenera kwambiri. Kuti izi zitheke, mankhwalawa amayamba ndi muyezo wochepetsetsa.

Pali zolakwika zingapo pakugwiritsa ntchito ma statins:

• Mankhwala amaletsedwa panthawi yomwe muli ndi pakati kapena poyamwa Chifukwa chiyani zili choncho? Mphamvu ya ma statins pa mwana wosabadwayo kapena khanda silikudziwika bwinobwino.
• Hypersensitivity kwa mankhwala opangira mankhwala kapena kusintha komwe kumagwiritsidwa ntchito m'mbuyomu,
• Kuchulukitsa michere ya chiwindi (transaminases) ndi bilirubin poyesa magazi a biochemical,
• Kuvulala kwa chiwindi chilichonse
• Matenda a shuga
• Kuthandiza ana kumatheka pokhapokha ngati ali ndi zaka 8 ndi mitundu yoopsa ya mabanja hypercholesterolemia.

Kukhazikitsidwa kwa ma statins ndi kusankha kwa mulingo woyenera kumachitika chifukwa cha matenda onse osamutsidwa komanso omwe alipo, komanso mankhwala omwe amagwiritsidwa ntchito.

Mukafuna kutumiza ma statins, ndikofunikira kuganizira mndandanda wazopondera ndikuwonetsetsa kuti ndizoyenera kugwiritsa ntchito.

Mukamagwiritsa ntchito chiyani?

Mndandanda waukulu wazotsatira zoyipa zomwe zingachitike ndikuvulaza kwawo zimachepetsa kugwiritsa ntchito ma statin popanda kuwunika kwenikweni kwa wodwalayo. Komabe, pali matenda angapo pomwe funso loti "bwanji ma statins" siloyenera, popeza kugwiritsa ntchito mankhwalawa kumatha kupititsa patsogolo patsogolo kwa matendawa m'matendawo, komanso kuchepetsa ngozi. Matendawa ndi monga:

1. Pachimake coronary syndrome wokhudzana ndi kuwonongeka kwa myocardial.
2. Pambuyo pambuyo sitiroko pambuyo ischemic atherosulinotic sitiroko.
3. Mitundu yamabanja ya hypercholesterolemia.
4. Inachita stenting, angioplasty kapena coronary artery bypass grafting.
5. Mitundu yosakhazikika ya angina pectoris.
6. Mkhalidwe pambuyo myocardial infaration.
7. Mitundu iliyonse yotulutsidwa ya atherosulinosis, limodzi ndi kuchuluka kwa mafuta m'thupi ndi LDL m'magazi.

Kugwiritsa ntchito ma statins kuyenera kufotokozedwa momveka bwino ndi dokotala yemwe akupezeka, zomwe zikuwonetsa kuchuluka ndi kuchuluka kwa Mlingo. Kutsatira kwambiri malangizowa kumakupatsani mwayi wogwiritsa ntchito mankhwalawa osawopa mavuto.

Malingaliro a Dr. Myasnikov pa chithandizo cha cholesterol yayikulu

Thupi limafunikira cholesterol, chifukwa imakhudzidwa m'njira zambiri zofunika. Pamodzi ndi chakudya, 20% yokha ya zinthu ngati mafuta imalowa, ndipo zotsalazo zimapangidwa m'chiwindi.

Chifukwa chake, ngakhale m'masamba, cholesterol chizindikiro chimatha kukhala chambiri. Chomwe chingatayike chingakhale chobadwa nacho, moyo wokhalitsa, zosokoneza bongo, komanso kuphwanya kagayidwe kazakudya.

Ndi hypercholesterolemia, ma statin nthawi zambiri amapatsidwa mankhwala, omwe amachepetsa mwayi wovuta. Monga mankhwala ena aliwonse, mankhwalawa ali ndi zovuta zake. Kuti timvetsetse kuopsa kwa cholesterol yayikulu komanso zomwe ma statins amatenga pakuchepetsa, Dr. Alexander Myasnikov athandizira.

Ndiyenera kumwa ma statin okhala ndi cholesterol yayikulu - About cholesterol

Kwa anthu omwe ali ndi cholesterol yayikulu m'magazi awo, chidziwitso chimakhala chofunikira ngati ma statins ndi oyipa pakuchepetsa cholesterol. Mbiri ya lipid ikatha kuwonetsa zonyansa za lipoproteins, madokotala amatenga mankhwala okwera mtengo omwe ali m'gulu la statin. Chilichonse chingakhale bwino, koma odwala ali ndi nkhawa kuti kudya kwawo nthawi zonse, ndiko kuti, mpaka kumapeto kwa moyo.

Cholesterol ndi chimodzi mwazinthu zofunika zomwe zimapanga chiwindi. Popanda izi, kupezeka komanso magawikidwe a maselo, kapangidwe ka kugonana ndi mahomoni ena, sizingatheke. Komabe, mankhwala ena a cholesterol ndi opambana. Imagwira ntchito m'magawo awiri:

• Zowononga (LDL) - lipoproteins otsika
• Zothandiza (HDL) - lipoproteins yapamwamba kwambiri

LDL ili ndi mphamvu ya atherogenic ndipo imathandizira kupezeka kwa zotsatirazi:

• atherosulinosis
• Matenda oopsa
• myocardial infaration
• atherosulinosis
• ischemia

Mkulu wa LDL atapezeka, funso loti muchepetse cholesterol ndi mapiritsi silinalingaliridwe. Gulu la mankhwalawa limalembedwa mosalephera.

Kodi ma statins ndi chiyani

Mankhwalawa amapangidwa kuti aletse michere ya chiwindi ndi ma adrenal gland, zomwe zimathandizira kupanga cholesterol. Zotsatira komanso ngati mankhwalawa amayenera kuledzera ndi cholesterol akufotokozedwera malangizo omwe amaperekedwa pa mankhwalawa:

• Zinthu zomwe zili m'mapiritsi zimaletsa kuchezanso kwa HMG, chifukwa chake mafuta omwe amapezeka ndi chiwindi amachepetsa ndipo zomwe zili m'madzi a m'magazi zimachepetsedwa.
• cholesterol yochepa kwambiri, osagwiritsidwa ntchito ndi othandizira a hypolipidemic, amachepetsedwa
• cholesterol yathunthu imachepetsedwa ndi 45%, lipoproteins yotsika pang'ono imachepetsedwa ndi 55-60%
• kulemera kwakukulu (kupindulitsa) cholesterol imakwera kwambiri
• chiopsezo cha matenda a mtima ndi matenda a sitiroko amachepetsa ndi 15-20%

Madera agawika m'mibadwo ingapo, ali ndi gulu la mitengo yosiyana ndipo amagwira ntchito mosiyanasiyana.

Chizindikiro chovomerezeka

Kutenga ma statins okhala ndi cholesterol yayitali kapena kwakanthawi kungadziwike pambuyo pakuwunika kwathunthu ndi dokotala. Nthawi zina, magulu awa a zinthu amatha kuvulaza thupi, choncho ndi mafuta ambiri a cholesterol, madokotala amatipatsa mankhwala osiyanasiyana.

Njira zamakono zikuphatikiza pa mankhwalawa ochizira matenda a mtima a gulu la ma statins. Izi zimachepetsa kufa pakati pa odwala komanso zimathandizira zotsatira zamankhwala. Komabe, ngakhale kwa okalamba odwala, madokotala sangapereke mankhwala a cholesterol popanda kufufuza koyambirira, mapindu ndi kuvulaza komwe kumakhala kofanana.

• kuteteza ischemic sitiroko ndi myocardial infaration
• Pokonzekera opaleshoni ya mtima ndi nthawi yotsatila pambuyo povutira, opaleshoni yodutsa ndi mitundu ina yolowerera
• pambuyo chitukuko chachikulu matenda matenda ndi mtima
• matenda a mtima

Zisonyezo zokhudzana ndi ma statins ochokera ku cholesterol, kugwiritsa ntchito komwe ndikokayikitsa:

• chiopsezo chochepa cha kuchepa kwa minofu ya mtima
• azimayi achichepere ndi achikulire asanasiye
• lembani 1 ndikulemba odwala 2 a shuga

Funso loti amwe mapiritsi a cholesterol muubwana, akatswiri akuganiza. Matenda amaperekedwa kwa ana omwe ali ndi vuto lalikulu, pakakhala zovuta zina zoyambitsidwa ndi chibadwa cha hypercholesterolemia ndi matenda a mtima.

Kusankhidwa kwa nsanamira

Kutengera madandaulo a wodwalayo ndikupeza deta atamuwunika, dotoloyo asankha kuti atenge mafuta a cholesterol. Ndi lingaliro labwino, gulu labwino la mankhwalawa limasankhidwa, poganizira matenda amtundu wanthawi zonse komanso osakhazikika. Ndikoletsedwa kuchita izi nokha.

Popereka mankhwala a statins, adotolo amawerengetsanso kuchuluka kwa ndalamazo, zomwe zingasinthe malinga ndi kusintha kwa kapangidwe ka magazi. Pachifukwa ichi, wodwalayo ayenera kupereka magazi pafupipafupi kuti awunikenso kusintha mtundu ndi mtundu wa ma statins.

Ndikofunikira kulabadira kuti ma statins ndi ovulaza cholesterol:

• anthu achikulire omwe amamwa mankhwala a shuga komanso matenda oopsa amatha kutenga minofu kumatha atatha ma statins
• Odwala omwe ali ndi matenda osachiritsika a chiwindi amalimbikitsidwa magulu omwe samakhudza chiwalo ichi (pravastatin, rosuvastatin)
• Pravastatin amawonetsedwa kwa odwala omwe ali ndi ululu wamisempha.

Pitani pazomwe zili

Ngati vuto la impso, a Leskol ("fluvastatin") ndi Lipitor ("atorvastatin") saloledwa, chifukwa ndi oopsa kwambiri

• Mitundu iwiri ya statins imaloledwa ndikuchepetsa kwakukulu
• kuphatikiza kwa ma statins ndi nicotinic acid ndikosavomerezeka. Izi zingayambitse kutsika kwa shuga wamagazi ndi magazi m'matumbo.

Ngati dokotala atakulemberani mankhwala okwera mtengo, simungathe kulowetsa m'malo anu ndi mitundu yotsika mtengo nokha.

Kuti mudziwe ngati ma statin amayenera kukhala oledzera ndi cholesterol wokwera pang'ono ndikofunikira kwa dokotala. Kutsika kwamafuta kosalekeza kumatha kuyambitsa kutopa, kuchepa kwa magazi m'thupi komanso matenda ena owopsa. Munthu sangakhale moyo wopanda cholesterol. Ndikofunikira kuti tichotse LDL, yomwe imamatira kukhoma lamankhwala ndikupanga ma atherosranceotic malo. HDL ndi mtundu wamafuta womwe umathandizira kuchotsa lipoproteins "zovulaza". Momwemo, zomwe zili, ngakhale zitachulukitsidwa, siziyenera kudandaula wodwalayo. Izi zikutanthauza kuti ziwiya zamunthu ndizotetezedwa kwathunthu.

Mutha kudziwa kuchuluka kwa mitundu yonseyo kokha ndi kuyezetsa magazi, komwe kumatha kuchitika m'mabotolo oyenerera.

Kuvulaza kwama statins

Ma cholesterol a statle sikuti amangothandiza, komanso ndi oyipa. Chikhalidwe cha mankhwala sichimapereka chilichonse chothandiza, kupatula kutsitsa mafuta m'thupi. Kuphatikiza apo, mankhwalawa ali ndi zovuta zambiri zomwe zimatha kubweretsa ngakhale kufa. Zina mwa izo ndi:

• kufooka
• kupweteka kwa minofu
• kutopa mwachangu
• Anachepetsa zogonana (makamaka mwa abambo)
• kukumbukira kusokonezeka ndi chidwi

Sizoletsedwa kutenga ma statin a amayi apakati komanso oyembekezera komanso anthu omwe ali ndi vuto lomwelo. Kafukufuku watsimikizira kuti mankhwalawa amawonjezera mwayi wopanga matenda amkati ndi 50 peresenti kapena kupitilira apo. Ndipo ngati kutenga ma statins limodzi ndi matenda ashuga, ndiye kuti chiwopsezochi chidzafika mpaka 85%. Chifukwa chake, madokotala sathamangira kukalimbikitsa ma statin kwa anthu omwe alibe mbiri yodwala matenda a mtima kapena omwe ali ndi vuto loti asanafike ku sitiroko.

Kodi ndifunika kumwa ma statins

Kudziwa kuvulaza kwa mankhwalawa, munthu angakane kulandira chithandizo mwanjira imeneyi. Koma mutha kupanga chisankho chomaliza pokhapokha poyerekeza zabwino ndi zoipa:

• kukankhira kutali ndi ma statins kuyenera kuloleza milingo yokhala ndi otsika ochepa (LDL), osapitilira 100 mg / dl
• ngati muyamba kutenga ma statins, muyenera kuchita izi kwa moyo wonse. Wodwala akaganiza zosiya kulandira chithandizo, mkhalidwe wakewo udzakulirakulira poyerekeza ndi woyamba
• ambiri sakhutira ndi kukwera mtengo kwa mankhwala
• ndikofunikira kuyang'anira kuwoneka kwa zoyipa, chifukwa chiopsezo chaumoyo chingabuke

Pambuyo pokambirana ndi katswiri wazachipatala, aliyense ayenera kusankha payekha kuti amwe mapiritsi a cholesterol. Chithandizo cha mankhwala osokoneza bongo ndi nkhani yachinsinsi kwa aliyense.

Ngati wodwala akuwopa kapena pazifukwa zina akukana ma statin, madokotala amapereka njira zina. Chimodzi mwa izi chikhoza kukhala chakudya chapadera. Ziphuphu zachilengedwe zimapezeka zochuluka mu zakudya zambiri: zipatso, zipatso, mafuta a nsomba, mafuta ophikira, ndi adyo.

Mitundu ya cholesterol imasankhidwa ndi dokotala malinga ndi momwe wodwalayo alili.

Phindu ndi zovuta za ma statins

Njira yamakono yotsatsira lipid yotsitsa cholesterol ndi imodzi mwamagawo olimbikitsa a chithandizo cha atherosulinosis. Udindo wotsogola m'malamulo azachipatala kwa odwala omwe ali ndi cholesterol yayikulu amakhala ndi ma statins - mankhwala omwe amachepetsa kupanga "zoyipa" zamafuta.

Ngakhale ntchito yothandizidwa ndi statin, kafukufuku wokhudza kuwopsa kwa mankhwalawa kwa nthawi yayitali adasindikizidwa posachedwapa mdziko la sayansi. Zowononga chiwindi ndi ziwalo zina zamkati sizimalola odwala omwe ali ndi matenda osatha kutenga mankhwalawa, ndipo kufunika kwa kugwiritsa ntchito nthawi yayitali kwa ma statins kumatha kuyambitsa mavuto. Ma Statin samangopindulitsa komanso katundu wovulaza: zabwino ndi zovuta za kumwa mankhwalawa zokhala ndi lipid zimaperekedwa kuwunikiridwa pansipa.

Lingaliro la Dr. Myasnikov pa cholesterol ndi ma statins

Dr. Myasnikov akuti zakudya mosakayikira ndizofunikira, koma cholesterol yokhayo singathe kuchepetsedwa ndi chakudya choyenera, chifukwa 80% ya cholesterol imapangidwa ndi chiwindi, ndipo ndiyofunikira kwa thupi.

Koma zakudya zimafunika, chifukwa sizithandiza kuti zinthu ziwonjezere.

Myasnikov pa statins akuti pazaka 15 zapitazi akhala mankhwala ogulitsa kwambiri padziko lapansi. Madokotala ena adatsutsa kuti sayenera kulembedwa pafupipafupi, koma chidziwitsochi chinabisidwa ndi kafukufuku wofufuza kotero kuti amawonjezera moyo wa anthu omwe ali ndi matenda a mtima.

Mankhwalawa amathandizira kuwonjezera cholesterol yabwino komanso kuchepetsa cholesterol yoyipa.Amathandizira kuti ayambitsenso mapepala a atherosulinotic komanso amathandizira kupewa kuwoneka kwatsopano.

Koma chisangalalo chidachepa pomwe maphunziro adawoneka kuti muyenera kumwa mankhwala moyo wanu wonse. Masiku ano, mankhwalawa sasankhidwa kuti akhale ndi cholesterol yayikulu.

Mabutolo okhudzana ndi ma statins a cholesterol akuti amayenera kuyikidwa pamene maulalo ali apamwamba kwambiri kuposa abwinobwino. Ngati cholesterol yoyipa imaposa 9 mmol / l. Matendawa nthawi zambiri amakhala obadwa kale ndipo amayamba kugwidwa ndi mtima ndi mikwingwirima akadali achichepere. Mwa anthu ena, cholesterol siili yokwera kwambiri.

Nthawi zina, ma statins amayenera kuperekedwa ngati, kuwonjezera pa cholesterol yambiri, zinthu zina zomwe zingayambitse matenda a mtima zimawonedwanso. Mwachitsanzo, ngati bambo wazaka 60 ali ndi kuchuluka kwa LDL komwe kuli kokulirapo kuposa momwe amachitira ndipo wodwalayo akusuta, mankhwala amafunikira. Koma vutoli likazindikira mwa mayi wazaka 40, sasuta ndipo amakhala ndi moyo wabwinobwino, cholesterol ndi 7 mmol / l, kupanikizika ndizabwinobwino, mutha kudwala. Ngati wachinyamata wazaka 30 amakhala ndi vuto la mtima, cholesterol 5 mmol / l, ndiye kuti ma statins adamulembera. Zonse zimatengera zaka, mawonekedwe a thupi, zikhalidwe zokhudzana. Mankhwala ndi Mlingo amasankhidwa poganizira ngati pali matenda a mtima ndi mitsempha yamagazi, zizolowezi zoyipa, kapena zina zomwe zingayike pangozi.

Mwambiri, mankhwala amalimbikitsa:

• ndi hypercholesterolemia, pamene Zizindikiro za otsika osalimba lipoprotein amapitilira muyeso,
• ndi matenda a mtima ndi mitsempha yamagazi monga ischemia, angina pectoris, kugunda kwamtima,
• ovulala kwambiri
• ngati pathological kusintha kagayidwe amawonedwa.

Koma mankhwala osokoneza bongo ali ndi zotsutsana nazo. Mwa matenda akulu a chithokomiro komanso impso, kudya kwawo sikokwanira. Komanso, mankhwala amaletsedwa kwa odwala omwe ali ndi matenda amkati, panthawi yoyembekezera komanso yoyamwitsa, komanso ngati pali zovuta zomwe zimachitika.

Zina mwazotsatira zake ndi myopathy, mutu, kusowa tulo, totupa, matumbo. Palibe chifukwa chomwe mungaphatikizire ma statin ndi zakumwa zoledzeretsa, chifukwa izi zimayambitsa chiwindi.

Ponena za mutu wa "ma statins: zabwino ndi zowononga," Dr. Myasnikov akuwonetsa kuti azilingalira zonse mosamala ndikuzitengera pokhapokha ngati pali zovuta kwambiri, chifukwa zakudya zocheperako zimatha kuwongoleredwa potsatira kudya. Pali magulu angapo a mankhwalawa, ndiye adokotala okha omwe angasankhe njira yoyenera. Ngati vutoli litha kukonzedwa popanda iwo, ndiye kuti ndibwino kuyesetsa kutsatira zakudya kaye. Izi zimapewetsa zinthu zomwe zikuipiraipira.

Elena Malysheva

Elena Malysheva ndiye wakuwonetsa TV waku Russia pa pulogalamu yaumoyo ndi Live Healthy. Kwa kanthawi amagwira ntchito ngati othandizira, kuteteza maganizo pa mtima wa mtima. Anali dokotala wochita zolimbitsa thupi kwakanthawi ndipo atagwira ntchito kwa zaka zingapo adakhala wothandizira ku dipatimenti ya Zamankhwala Zamkati ku Russia State Medical University, komwe tsopano amakambirana nthawi ndi nthawi.

Pulogalamu ya "Live Healthy", yomwe imapangidwa pa Channel One, idabweretsa mbiri yosasangalatsa kwa owonetsa, monga zokambirana zimakambidwa pamawa.

Malysheva pa cholesterol ndi ma statins

Ma Statin ndi mankhwala apadera. Maziko omwe adapanga anali bowa wa oyisitara, chifukwa ali ndi lovastatin, yomwe imatsitsa mafuta m'thupi.

Mankhwalawa amachepetsa cholesterol plaque. Amatsitsa cholesterol, komanso amathandizira pa cholembera mkati momwe mumakhala mafuta amadzimadzi.

Statins imathandizanso kukhazikika kwa chotengera, kuchepetsa kutupa. Zochita zamankhwala zimakhazikika pachiwindi, chifukwa zimatulutsa lipoproteins.

Statins amachita telomerase ndipo kwakukulu kutsekereza kufupika kwa DNA, kotero kuti amachepetsa kukalamba kwa chamoyo chonse.

Koma monga Dr. Myasnikov pa statins, Malysheva akuti kuti athandizidwe, mankhwala ayenera kumwedwa moyenera:

1. Amayenera kuledzera madzulo, ndiye kuti chiwindi chimatulutsa cholesterol, ndipo ma statin amatha kugwira lipoproteins yotsika, osakhudza cholesterol yabwino.
2. Mutha kumwa nawo kokha ndi madzi, chifukwa timadziti ndi zinthu zina zimatha kuletsa mphamvu ya mankhwala. Madzi a mphesa ndi mphesa ayenera kusamala makamaka.
3. Simungathe kuphatikiza ma statins ndi mankhwala osokoneza bongo a antibacterial.

Dokotala amayenera kudziwitsa panthawi yomwe akukonzekera kuti wodwalayo ayenera kuyeza mafuta m'thupi pakatha miyezi itatu iliyonse. Muyenera kuyesetsa kutsimikizira za 5.2 mmol / l, ngati munthu sakudandaula, koma makolo ake adadwala matenda a mtima. Ngati zakhudza munthu pambuyo pa sitiroko, adayang'anidwanso kapena kuwongolera m'mitsempha mozungulira, ndiye kuti mulingo wake uyenera kukhala 4.5-4.7 mmol / l. Mankhwalawa amayenera kukhala osinthika nthawi zonse, komanso kusintha kwa mankhwalawa, koma simungathe kusiya kuigwiritsa ntchito, pokhapokha pokhapokha ngati mungadalire kusintha thanzi lanu.

Pomaliza

Phindu ndi zovuta za ma statins, malinga ndi Dr. Myasnikov, ndizoyenera. Anatinso kuti kumwa mankhwalawa sikulimbikitsa nthawi zonse. Ngati izi zikugwira ntchito kwa munthu wokalamba pambuyo pa vuto la mtima kapena wodwala yemwe ali ndi cholowa cholowa, ndiye kuti simungathe kuchita popanda mankhwalawa. Elena Malysheva akuti ma statins ndi mankhwala ochizira matenda amtima. Amangopanga ma atherosselotic plaques kukhala otetezeka, komanso amakhudza telomerase. Katunduyu amakulolani kuti muchepetse kukalamba kwa thupi, koma adzatengedwa mu moyo wonse.

Chifukwa chiyani cholesterol yapamwamba imakhala yoopsa

Cholesterol m'thupi la munthu imagwira ntchito zofunika, kuphatikizapo kutenga nawo gawo pokhudzana ndi kugonana ndi mahomoni a steroid, ma asidi a bile, komanso vitamini D, yemwe amatsimikizira kukhazikika kwa chitetezo cha mthupi komanso kulimba kwa zinthu za m'mafupa a axial. Cholesterol ndiyofunikanso kuonetsetsa kukhazikika kwa mapuloteni omwe amapanga membrane wa cell kuti azitha kutentha (mwachitsanzo, ndi febrile syndrome).

Ngakhale izi, kumwa mopitilira muyeso kwa zinthu zomwe zimatha kukhala "zotsatsa" za cholesterol sizikulimbikitsidwa, chifukwa ma lipoproteins otsika kwambiri amatha kupanga chifukwa cha microsynthesis yama mamolekyulu a cholesterol amatha kupanga crystalline precipitate.

Ma kristalo a cholesterol amaphatikizana ndi zolembera zomwe zimakhazikika pamakoma amitsempha yamagazi ndikupanga chiwopsezo cha matenda otsatirawa:
• atherosulinosis
• matenda a mtima
• myocardial infaration
• kugwidwa muubongo
• matenda oopsa oopsa (kuchuluka kwokhazikika kwaapanikizidwe mpaka ku 180/120 ndi pamwamba).

Mankhwala akuluakulu ochepetsa cholesterol yamagazi ndi ma statins. Iyenera kuikidwa munthawi yomweyo ndi chakudya chomwe chimaletsa kugwiritsa ntchito zinthu zomwe zili ndi zinthu zambiri za "zoyipa" (otsika maselo owonjezera) cholesterol (masoseji, confectionery ndi mafuta ndi zigawo za mafuta, mafuta anyama, Bacon, ndi zina zambiri).

Ma Statin - mankhwalawa ndi otani

Statin ali m'gulu la mankhwala ochepetsa lipid - mankhwala omwe amachepetsa magawo azigawo zosiyanasiyana za lipids (mafuta) mu minofu ndi ziwalo za thupi. Zopindulitsa ndi kuvulaza kwa mankhwala a statin a cholesterol yayikulu akadali nkhani yovuta m'magulu azachipatala, popeza palibe umboni wokwanira kuti alole kutsimikiza kwa 100% ponena za kuphatikiza kwakukulu kwa mankhwalawa popewa matenda a atherosclerosis ndi matenda a coronary.

Pomwe ma statins adalembedwa

Musanafotokozere mwatsatanetsatane zovuta komanso kuvulaza kwa oimira gulu lachiwonetsero cha thupi, ndikofunikira kudziwa kuti adokotala angakupatseni mankhwala liti.

Statins ndi lipid-kuchepetsa mankhwala omwe mawonekedwe ake amachitidwe amaphatikizidwa ndi kusankha kuletsa kwa HMG enzyme CoA reductase, gawo lofunikira pakapangidwe ka cholesterol ndi zigawo zake za atherogenic. Chizindikiro chakugwiritsa ntchito ma statins:

• monga gawo la zovuta la hypercholesterolemia (cholesterol yapamwamba),
• ndi mapangidwe a hypercholesterolemia (mabanja a heterozygous, homozygous),
• kukonza mafuta kagayidwe kachakudya kapena mwatsatanetsatane matenda chithunzi cha mtima, cerebrovascular matenda.

Zothandiza katundu ndi limagwirira a zochita za ma statins

The bioavailability mankhwala ambiri m'gulu lino siopitilira 20%, ndipo pazipita magazi mu plasma amafika 5 mawola kukhazikitsa. Kuyankhulana ndi albumin ndi mapuloteni ena a plasma osachepera 90%.

Zotsatira zakugwiritsidwa ntchito kwa ma statins zimachitika chifukwa cha mankhwalawa omwe ali ndi mankhwalawa:
• kusankha chopinga cha HMG-CoA reductase, ma enzyme omwe amapanga mevalonic acid, pomwe ma cholesterol amapangira,
• kuchuluka kwa hepatic receptors a otsika kulemera lipoproteins,
• kutsika kwa plasma woipa wa cholesterol yonse "yoyipa" ndi "triglycerides" pamene ikuthandizira kupangika kwa cholesterol yayikulu ("yabwino").

Chimodzi mwazinthu zofunikira za ma statins zimawerengedwa kuti ndizothandiza pakugwira ntchito kwa mtima. Malinga ndi ziwerengero, theka la odwala omwe amalandila mankhwala a statin, kukula kwa minofu ya mtima kumafanana ndi chikhalidwe cha thupi, chomwe ndi chizindikiro cha kukana kwambiri kwa nkhawa komanso mawonekedwe a myopia.

Zotsatira zabwino kwambiri zochizira zimawonedwa pakutha kwa sabata lachinayi la chithandizo. Ma Statin amatengedwa ngati chithandizo chokwanira cha hyperlipidemia kokha mwa anthu a zaka zapakati (mpaka zaka 50). Odwala a senile ndi okalamba, kutsogolera kupewa matenda a atherosulinosis amapatsidwa mankhwala ochizira.

Zitha kuvulaza

Ngakhale mapiritsi a cholesterol abwino kwambiri ayenera kuperekedwa ndi adokotala anu, chifukwa nthawi zina amatha kuyambitsa zovuta komanso zovuta.

Zotsatira zoyipa kwambiri za mankhwala a statin ndi:
• Kuchepa kwa chiwerengero cha maselo othandiza magazi kuundana (chizolowezi ndi 150 * 10 9 / l), limodzi ndi kufinya kwam'mimba,
• mutu ndi chizungulire,
• kuwonongeka kwa mitsempha yotumphukira, yomwe imayambitsa kufalikira kwa zikopa pakhungu ndi minofu.
• kuchuluka kwa hepatic transaminases,
• kupuma movutikira ntchito (kufupika, chifuwa),
• kupweteka kwa minofu (myalgia),
• proteinuria (mapuloteni mu mkodzo).

Chiwopsezo chachikulu chogwiritsa ntchito ma statins kwa nthawi yayitali chimakhudzana ndi kuphwanya kwa metabolidi ya lipid-carbohydrate komanso kukula kwa matenda a shuga a mtundu 2. Kwa odwala omwe ali ndi zaka zopitilira 50, pafupipafupi matendawa amathandizidwa ndi lipid-kuchepetsa mankhwala opitilira 40%.

Mfundo zofunikira zopangira ma statins

• Musanagwiritse ntchito mankhwala, odwala onse omwe ali ndi hypercholesterolemia ayenera kulimbikitsidwa njira zowongolera kagayidwe ka mafuta pogwiritsa ntchito zakudya zolimbitsa thupi komanso zokwanira zolimbitsa thupi, kukana zizolowezi zoipa,
• kolesterol ngati sabwerera mwakale pakatha miyezi itatu osagwiritsa ntchito mankhwala, madokotala nthawi zambiri amakupatsani mankhwala,
• statins yozikidwa pa atorvastatin ndi simvastatin amayamba kuchita pambuyo pa masabata awiri a kudya pafupipafupi, kutengera rosuvastatin - mwachangu. The achire zotsatira za mankhwalawa zimachitika pambuyo mwezi umodzi kukonzekera ndi njira yonse ya mankhwala kumatenga,
• Mankhwala a statin nthawi zambiri amakhala nthawi yayitali, ndipo amatenga miyezi ngakhale zaka.

Statins, mndandanda wa mankhwala ochizira cholesterol yayikulu

Zizindikiro za ma statins ndi matenda ndi ma pathologies omwe amakhudzana ndikuwonjezereka kwa mafuta a cholesterol komanso mapangidwe a cholesterol plaques.Izi sizongokhala atherosulinosis, komanso matenda a mtima (vuto la mtima, matenda amitsempha yamagazi, matenda oopsa), komanso chiwopsezo chotulutsa magazi m'mitsempha yamagazi. Nthawi zina, ma statins amatha kulembedwa m'maphunziro ochepa kuti athetse metabolidi ya lipid kwa anthu omwe ali ndi zizolowezi zoyipa (makamaka, akusuta) kapena onenepa kwambiri.

Mndandanda wa mankhwala ochokera pagululi la statins, komanso mwachidule mwachidule komanso mtengo wake:
• Rosuvastatin (300-650 ma ruble). Zomwe zimagwira ndi calcium wa rosuvastatin. Mankhwala ndi mankhwala 20 mg 1 nthawi patsiku. Ngati wodwala alandira chithandizo cha rosuvastatin koyamba, muyenera kuyamba ndi mlingo woyenera (osapitirira 20 mg). Analogs: Rosucard, Suvardio, Roxer.
• Simvastatin (30-120 rubles). Imafotokozedwa nthawi imodzi patsiku mu 10 mg mg wa madzulo. The pakati pakati kumwa mankhwala ndi kudya ayenera kukhala osachepera 2 maola. Analogs: Vasilip, Simvor, Simvastol.
• Lovastatin (240 ma ruble). Kugwiritsa ntchito Lovatstain kumafuna kusintha kwa mankhwalawa kamodzi pakatha milungu 4 iliyonse. Mlingo wapamwamba wa tsiku ndi tsiku ndi 80 mg (mu waukulu magawo awiri). Tengani ndi chakudya. Analogs: Medostatin, Cardiostatin.
• Leskol (2560-3200 rubles). Chomwe chimagwira ndi fluvastatin sodium. Chimagwiritsidwa ntchito makamaka pochiza matenda osagwirizana ndi hyperlipidemia. Tengani mlingo wa 40-80 mg wa patsiku.
• Atorvastatin (170-210 ma ruble). Tengani nthawi iliyonse masana, ngakhale kudya kwambiri. Mlingo watsiku ndi tsiku umachokera pa 10 mpaka 80 mg. Analogs: Atoris, Liprimar, Anvistat.
• Lipobay (310 ma ruble). Zomwe zimagwira ndi cerivastatin sodium. Tengani pakamwa 1 kamodzi patsiku mu 20-25 mg (koma osapitirira 80 mg).

Poyerekeza ndi kugwiritsa ntchito ma statin ena, wodwalayo amatha kumva kupweteka kwapweteka, kukokana kwam'mimba pamimba, kupuma chifukwa (kupuma kwa mphuno, chifuwa). Chiwopsezo cha zotsatira zosafunikira panthawi ya mankhwala omwe amapezeka ndi ma statins amawonjezereka ngati atengedwa nthawi yomweyo ndi mankhwala omwe amalepheretsa kuchepa kwa lipid kwa mankhwalawa.

Mankhwala osokoneza bongo omwe sangaphatikizidwe ndi ma statins

Chiwopsezo chokhala ndi matenda omwe amadziwika ndi kuchuluka kwa myopathy amawonjezeka kangapo ngati wodwala atenga ma statins nthawi yomweyo ndi mankhwala otsatirawa:
• aerosol antimycotic,
• antibacterial mankhwala ochokera ku gulu la macrolide (azithromycin, clarithromycin, erythromycin),
• michere (micrate) ya fibroic acid,
• ma immunosuppressants (mwachitsanzo cyclosporin),
• Verapamil
• Kukonzekera kwa nicotinic acid ndi zotumphukira zake.

Chiwopsezo cha zovuta zimachulukidwanso mwa odwala omwe amadalira mowa, kutsatira zakudya zochepa zama calorie kapena kukhala ndi mbiri yovuta ya chiwindi. Wodwala akamuchita opareshoni, ma statin ayenera kuthetsedwa.

Ndi zoletsedwa kumwa ma statins onse ndi madzi a mphesa.

Limagwirira a zochita za statins

Statins "imagwira" pamlingo wa biochemical, kutseka imodzi mwa michere yofunika pama kapangidwe ka cholesterol m'chiwindi. Chifukwa chake, mankhwalawa ali ndi zotsatirapo zamankhwala:

• kale mwezi woyamba amachepetsa kwambiri kuyambika kwa cholesterol,
• amachepetsa kupanga "zoipa" atherogenic lipids - LDL cholesterol, VLDL, TG,
• mosakhazikika kuwonjezera kuchuluka kwa "kofunikira" kachigawo ka cholesterol - HDL.

Kuphatikiza apo, pakuwonjezera kuchuluka kwa zolandilira za HDL pamtunda wa hepatocytes, ma statin amathandizira kugwiritsidwa ntchito kwawo ndi maselo a chiwindi. Chifukwa chake, kuchuluka kwakasokonekera kwa ma lipoproteins okwera komanso otsika kumabwezeretsedwa, ndipo coheroffiel ya atherogenic imabwereranso.

Ubwino wama statins ndi:

• Kuchepetsa chiwonetsero cha ischemic kwa odwala omwe ali ndi magazi osakwanira kumtima ndi ubongo,
• kupewa matenda amtima mwa anthu omwe ali pachiwopsezo (choposa zaka 60, kusuta, kumwa mowa mwauchidakwa, matenda ashuga, ndi zina zotere),
• Kuchepetsa chiopsezo chakupha cha matenda amitsempha yamagazi ndi matenda am'mimba otsekemera,
• kukonza moyo wa odwala.

Statins amatalikitsa moyo

Si chinsinsi kuti odwala omwe ali ndi cholesterol yokwezeka komanso mawonetseredwe azachipatala a atherosulinosis amathamangitsa zovuta zakumaso monga pachimake myocardial infarction, kusokonezeka kwamagazi m'matumbo a miyendo ndi ziwalo zamkati, komanso sitiroko.

Zonsezi zimalumikizidwa ndi makina wamba popanga dongosolo la matenda:

1. Kuwonjezeka kwa kuchuluka kwa cholesterol yonse ndi zigawo zake za atherogenic m'magazi (LDL).
2. The lipids pa makoma a mitsempha, kulimbikitsidwa ndi cholumikizana minofu mafupa - kapangidwe ka atherosulinotic (cholesterol) zolengeza.
3. Kuphwanya magazi kwa ziwalo zamkati ndi kuchepetsedwa chifukwa cha kuchuluka kwa mafuta m'thupi m'makoma amitsempha. Choyamba, minofu ya mtima ndi ubongo zimavutika, chifukwa ndi iwo omwe amafunikira mpweya wabwino nthawi zonse ndi michere,
4. Maonekedwe a zizindikiro zoyambirira za ischemia: ndi kuwonongeka kwa mtima - kupweteka kosasangalatsa kumbuyo kwa kupsinjika, kupuma movutikira, kuchepa kwa kulolerako masewera olimbitsa thupi, kuperewera kwa mpweya wabwino kuubongo - chizungulire, kuyiwala, kupweteka kwa mutu.

Ngati simulabadira izi pakanthawi kochepa, kulephera kwa magazi kumapita patsogolo kwambiri ndipo kumatha kubweretsa zotsatira zowopsa m'moyo - matenda a mtima kapena stroke.

Kuphatikizika kwa minofu yamtima ndikusintha kosasintha kwa thupi mu minofu ya mtima, kuphatikizapo necrosis (kufa kwa maselo) ndi kutupa kwa aseptic. Mkhalidwewo ukuwonekera ndi ululu wowopsa mumtima, mantha, mantha a imfa. Ngati necrosis yakhudza khoma lonse la mtima, vuto la mtima limatchedwa transmural. Pakakhala zotsatira zabwino, "kukulitsa" malo a necrosis omwe ali ndi minyewa yolumikizana kumachitika, ndipo wodwalayo amakhalabe ndi khungu pamtima.

Ngati kuwonongeka kukukulira, ndiye kuti mtima sungathe kugwira ntchito zake zakukopa magazi. Panthawi yovuta ya vuto la mtima, kulephera kwa mtima, mapapu, ndipo nthawi zina kufa kwa wodwala kumachitika.

Stroko itha kupha - kuphwanya magazi mu gawo la ubongo. Ngati kuwonongeka kwa ischemic kwakula m'dera lofunika la ubongo, kufa kumatha kuchitika nthawi yomweyo. Mavuto onse oopsa a atherosulinosis amapezeka mwadzidzidzi ndipo amafunikira kuchipatala msanga.

Phindu la ma statins popewa komanso kuchiza matenda a atherosulinosis ndiwofunika kwambiri: mankhwalawa amasunga cholesterol mkati mwa zomwe akufuna, amalepheretsa kupangika kwa mapangidwe a atherosrance Kuphatikiza apo, ma statins amachepetsa kufa chifukwa chobwereza mtima komanso kuwonongeka kwa odwala omwe ali ndi cholesterol yambiri m'magazi, atherosulinosis yayikulu komanso kusokonezeka kwa magazi.

Zowononga chiwindi

Monga mukudziwa, mpaka 80% ya mafuta enaake am'mimba omwe amapangidwa m'chiwindi. Mankhwalawa ndi ma statins, njira zomwe zimapangidwira zimasokonekera, ndipo zinthu zomwe zimapangidwa ndi zigawo za atherogenic lipid zimatha kuyambitsa zovuta ku hepatocytes.

Komabe, kuwonongeka kwa maselo a chiwindi sikuchitika mwa odwala onse. Sikovuta kutsatira zovuta zomwe zimapezeka chifukwa cha ma statins: ndikukwanira kuyang'anira pafupipafupi zowonetsa ma laboratori ndikuyesa mayeso a chiwindi.

Kusanthula kwa mayesero a chiwindi kumaphatikizapo zizindikiro ziwiri:

• Alanilamimotransferase (AlAT, ALT) - ponseponse 0.12-0.88 mmol / l,
• Aspartate aminotransferase (AsAT, AST) - mawonekedwe ndi 0.18-0.78 mmol / l.

Kuphatikiza apo, ndikofunikira kuyesa mayeso a bilirubin yathunthu komanso mwachindunji - izi zimagwiritsidwa ntchito nthawi zambiri ndi akatswiri odziwa ntchito za chiwindi. Kuchuluka kwa bilirubin kungasonyeze kuphwanya kwakukulu pamlingo wa hepato-cellular. Pankhaniyi, kusankhidwa kwa ma statins sikulimbikitsidwa.

Mwa chikhalidwe chawo komanso zamankhwala, AlAT ndi AsAT ndi ma enzymer omwe amalowa m'magazi pomwe maselo a chiwindi awonongeka. Nthawi zambiri, hepatocytes amasinthidwa pafupipafupi: akale akafa, malo awo amaloledwa ndi atsopano. Chifukwa chake, zinthu izi m'malingaliro ocheperako zimapezeka m'magazi.

Koma ngati, pazifukwa zina, kufa kwa hepatocytes kumakulirakulira (ngakhale ndi zovuta za chiphe ndi mankhwala osokoneza bongo, matenda a chiwindi osachiritsika, ndi zina), ndiye kuti zomwe zimapanga ma enzymes izi zimawonjezeka kangapo. Ngati mumamwa ma statin kwa nthawi yayitali, kuyezetsa kwa chiwindi kumatha kupitilira miyeso yofananira ndi 2-4.

Njira yoyenera kwa wodwala yemwe akungoyamba kumwa ma statins ndikuyenera kuyezetsa magazi musanalandire chithandizo komanso pambuyo pa miyezi 1-2 ya mankhwala okhazikika. Ngati AlAT ndi ASAT malingana ndi zotsatira za kusanthula koyambirira ndi kwachiwiri zili m'malire abwinobwino, ndiye kuti ma statin alibe zovuta pa chiwindi cha wodwalayo, ndipo kuchira nawo kungapindulitse thupi. Ngati musanamwa mankhwalawa, kuyezetsa magazi kwa chiwindi kunali kwabwinobwino, koma kenako kumawonjezeka kwambiri, ndiye, mwatsoka, ma statin amavulaza chiwindi cha wodwalayo kuposa momwe amachitira m'magazi. Pankhaniyi, ndikofunikira kukaonana ndi dokotala kuti asankhe njira zina zochiritsira. Zotsatirazi ndizotheka:

• Kutha kwa ma statins. Nthawi zambiri, kuchuluka kwa AlAT ndi ASAT kukhala koopsa ku thanzi, chinthu chofunikira kwa katswiri ndikusiya mankhwalawo. Kuti mupewe kuvulaza, komwe mu nkhani iyi imapindulitsa kwambiri, ndikulimbikitsidwa kusinthana ndi magulu ena a mankhwala opatsirana ndi lipid, mutangobwezeretsanso magawo a mayeso a chiwindi. Kuphatikiza apo, odwala sayenera kuyiwala kuti njira yayikulu yochizira cholesterol yapamwamba ndi atherosclerosis imakhalabe chakudya chopezeka ndi mafuta a nyama, komanso zolimbitsa thupi.
• Kusintha kwa Mlingo. Mlingo wofananira wa ma statins onse ndi ofanana: mankhwalawa amaperekedwa kamodzi patsiku, mlingo wocheperako ndi 10 mg, ndipo wokwanira ndi 80 mg. Njira yosankhira mlingo woyenera wodwalayo imatha kutenga nthawi yayitali: kumayambiriro kwa chithandizo, monga lamulo, anthu onse omwe ali ndi atherosclerosis ndi cholesterol yayikulu amamwa kumwa statin iliyonse ndi 10 mg. Ndipo, pakatha milungu 2-4 kuyambira poyambira kupatsidwa mankhwala pafupipafupi, wodwalayo amapatsidwa mayeso olamulira a cholesterol ndi atherogenic lipids, ndipo zotsatira zake zimayesedwa. Ngati 10 mg ya mankhwalawa "sakupirira", ndipo cholesterol choyambirira chimakhalabe pamlingo womwewo kapena kuchuluka, ndiye kuti kuchuluka kwake kumachulukitsidwa, i.e. mpaka 20 mg. Chifukwa chake, ngati pakufunika kutero, mutha kuwonjezera pang'onopang'ono kuchuluka kwa ma statins mpaka 80 mg.

Mokulira kuchuluka kwa mankhwalawa komwe wodwala amafunikira kumwa, ndizomwe zimapweteka kwambiri kwa chiwindi. Chifukwa chake, odwala omwe amamwa mankhwala tsiku lililonse 80 mg ndikukumana ndi zovuta zake, mlingo ungathe kuchepetsedwa (mogwirizana ndi dokotala).

• Malangizo ena othandizira chithandizo ndi ma statins - amasankhidwa payekha.

Kuphatikiza apo, odwala onse omwe amatenga ma statins ayenera kudziwa za zowopsa zawo pachiwindi ndikuyesera kuteteza chiwalo ku zotsatirapo zoipa za chilengedwe:

• kuchepetsa zakudya zamafuta okazinga m'mafuta,
• Siyani mowa ndi kusuta,
• Osamamwa mankhwala ena popanda malangizo a dokotala.

Zowopsa pamisempha ndi mafupa

Vuto linanso lodziwika bwino la ma statins limakhudzidwa ndi kukhudzidwa kwa minofu ya mafupa. Mwa odwala ena, mankhwala amachititsa kupweteka kwambiri kwa minofu (kupweteka, kukoka), makamaka madzulo pambuyo pa tsiku lokonzekera.

Kupanga kwa chitukuko cha myalgia kumalumikizidwa ndi kuthekera kwa ma statins kuwononga myocyte - maselo am'mimba. M'malo mwa maselo owonongedwa, kutupa kumayambitsa - myositis, lactic acid imabisidwa ndikuwakwiyitsa ma nerve receptors.Kupweteka kwa minofu mukamamwa ma statins kumandikumbutsa zovuta kwambiri pambuyo pogwira ntchito zolimbitsa thupi. Nthawi zambiri, minyewa yam'munsi yotsika imavutika.

Rhabdomyolysis ndi gawo lovuta la myopathy syndrome. Mkhalidwewo ukuwonekera ndi kufa kwakuthwa kwakukulu kwa gawo lalikulu la minyewa, kuyamwa kwa zinthu zowola m'magazi ndikutukuka kwaimpso. Mwanjira ina, impso zimalephera, sizitha kuthana ndi kuchuluka kwa zinthu zapoizoni zomwe zimayenera kuchotsedwa m'thupi. Ndi makonzedwe a rhabdomyolysis, wodwalayo ayenera kuchipatala mwachangu m'chipinda cha ICU kuti awongolere ntchito zofunika.

Popewa kukula kwa matenda oopsawa, odwala onse omwe amatenga ma statins amalangizidwa kuti aphatikizire kuwunika kwa creatine phosphokinase (CK), ma enzyme omwe amapezeka mu myocyte ndipo amatulutsidwa m'mitsempha yamagazi panthawi ya minofu necrosis, pokonzekera pafupipafupi. Chikhalidwe cha CPK m'mwazi ndi 24-180 IU / l. Ndi kukula kwa chizindikirochi pakuwongolera kuwongolera, tikulimbikitsidwa kusiya kugwiritsa ntchito ma statins kapena kuchepetsa mlingo.

Pafupipafupi, odwala omwe amapezeka ma statins amakumana ndi zoopsa zolumikizana. Kuvulaza kwa mankhwala ochepetsa mphamvu ya cholesterol kumakhala ndi kusintha kuchuluka ndi mphamvu zamagetsi am'kati mwa intraarticular fluid. Chifukwa cha izi, odwala amakhala ndi nyamakazi (makamaka mafupa akulu - bondo, m'chiuno) ndi arthrosis. Ngati wodwala wotere sanapatsidwe thandizo la panthawi yake, ndikupita patsogolo kwa vutolo, mapangidwe olumikizana angapangidwe - kuphatikizidwa kwazomwe zimayambira. Chifukwa cha izi, zimayamba kuvuta kuyenda molumikizana, ndipo posakhalitsa zimasunthika.

Vuto lamanjenje

Kutenga ma statins kungayambitse zotsatirazi zamagetsi:

• mutu
• kugona, kusintha kwa kugona, zolakwika,
• kugona
• chizungulire
• asthenia wamkulu (kufooka, kutopa, malaise),
• kusokonezeka kwa kukumbukira
• zovuta zam'maganizo - kutayika kapena, m'malo mwake, mawonekedwe a zomverera m'miyendo kapena mbali zina za thupi,
• kulawa kosokoneza
• kusokonezeka kwa kutengeka mtima (kusakhazikika) - kusintha kwadzidzidzi kwakumaso ndi kuwonetsa zakukhosi, kulira, kukwiya,
• ziwalo zamkati, zowonetsedwa ndi asymmetry ya nkhope, kuchepa kwa ntchito zamagalimoto ndi chidwi cha mbali ya zotupa.

Muyenera kumvetsetsa kuti sizotsatira zonse zoyipa izi zomwe zimadza mwa wodwala wina. Mwambiri, kusinthasintha kwa iliyonse sikupitirira 2% (malinga ndi kafukufuku wazachipatala yemwe ali ndi maphunziro oposa 2500). Popeza malangizowo akuyenera kuwonetsa zonse zomwe zingatheke chifukwa cha ma statins m'thupi, osaphatikizidwa kamodzi pazoyeserera zachipatala, mndandandandawu umawoneka wodabwitsa. M'malo mwake, odwala ambiri omwe ali ndi atherosulinosis omwe amatenga ma statins sangayang'ane ndi zoopsa zomwe zimachitika chifukwa cha mankhwalawa.

Zowopsa pamtima ndi m'mitsempha yamagazi

Ngakhale pali phindu lalikulu lomwe ma statins amakhala nawo pamtima, nthawi zina, mu 1-1,5% ya milandu, kukulitsa zotsatira zoyipa kuchokera kuzinthu zoyendayenda ndizotheka. Izi zikuphatikiza:

• palpitations
• zotumphukira vasodilation, kugwa magazi,
• migraine chifukwa cha kusintha kwa kamvekedwe ka ziwiya zaubongo,
• nthawi zina - matenda oopsa,
• arrhasmia,
• mu masabata oyamba ovomerezeka - mawonekedwe owonjezereka a angina pectoris, kenako kukula.

Zotsatira zoyipa kuchokera ku kupuma

Mavulidwe a statins kupita ku kupuma kwamphamvu ndi awa:

• kuchepa pang'onopang'ono kwa chitetezo chokwanira komanso kukula kwa matenda opatsirana m'magawo apamwamba a kupuma (sinusitis, rhinitis, pharyngitis),
• kupitirira kwa matenda komanso kufalikira kwake kumunsi kwamkati mwa kupuma (bronchitis, chibayo),
• kulephera kupuma - dyspnea,
• Mphumu ya bronchial ya chiyambi chosakanizika,
• mphuno.

Vuto impso ndi kwamikodzo dongosolo

Zotsatira zoyipa zama statins pamitsempha yamagazi ndi:

• kukula kwa matenda a urogenital chifukwa kuchepa kwa chitetezo chathupi,
• Matenda opatsirana mwachangu ndi mawonekedwe a cystitis - kukodza mwachangu, kupweteka kwa kuchuluka kwa chikhodzodzo, kupweteka ndi kuwotcha panthawi ya kutulutsa mkodzo,
• kuwonongeka kwaimpso, mawonekedwe a zotumphukira edema,
• kusintha kwa mayeso a labotale kwamikodzo: microalbuminuria ndi proteinuria, hematuria.

Thupi lawo siligwirizana

Hypersensitivity zochitika pachithandizo cha ma statins ndizosowa. Odwala omwe akutenga ma statins kutsitsa cholesterol akhoza kukumana:

• zotupa pakhungu
• kuyabwa
• wamba kapena edema yapafupi,
• dermatitis
• urticaria.

Kukula kwa anaphylactic shock, ngozi zowopsa ma syndromes (Lylel, Stevens-Jones) ndi zovuta zina zonse zomwe zimayipa zidalembedwa pamilandu yokhayokha panthawi yomwe maphunziro akupitilira malonda adatsatsa. Chifukwa chake, amaonedwa kuti ndi achabechabe.

Zotsatira zoyipa za ma statins pa mwana wosabadwayo

Kuchiza ndi ma statins a amayi apakati komanso oyamwitsa sikuletsa. Kuphatikiza apo, ngati mankhwala omwe ali ndi mankhwala omwe amachepetsa cholesterol amalimbikitsidwa kwa mayi wazaka zoyambira kubereka (zaka 15 mpaka 155, kapena okulirapo - musanadutse), ndiye asanamutenge, akuyenera kuonetsetsa kuti ali ndi pakati, ndipo agwiritse ntchito njira zabwino zolerera panthawi ya mankhwalawa .

Ma Statin ndi mankhwala ochokera ku gulu la X la mwana wosabadwa. Maphunziro aumunthu sanachitidwe, koma kuyesa kwa nyama yothandizira ntchito kwawonetsa kuti kuyang'anira kukonzekera kwa atorvastatin kwa makoswe achikazi kumapangitsa kuchepetsedwa kwakukulu kwa kulemera kwa ana. Komanso, mu zamankhwala, pali vuto limodzi lodziwika la kubadwa kwa mwana yemwe ali ndi zovuta zingapo pambuyo poti mayi watenga Lovastatin mu trimester yoyamba ya mimba.

Kuphatikiza apo, cholesterol ndi chinthu chofunikira pakukula kwabwinobwino ndi kukula kwa mwana wosabadwayo. Statins imadutsa mosavuta chotchinga cha hematoplacental ndikudziunjikira m'magazi aana kwambiri. Popeza mankhwalawa, chifukwa cha kuletsa kwa HMG-CoA reductase, amachepetsa kwambiri kapangidwe ka cholesterol m'chiwindi, mwana wosabadwayo angapeze kusowa kwakukulu kwa mowa wamafuta awa ndi zotumphukira zake.

Zambiri za mankhwala a statin

Dokotala asanakusankhani mankhwala ofunikira kwa gulu la ma statins kwa inu, ndikofunikira kuti mupimidwe thupi lonse ndikupita:

• kusanthula kwa matenda a m'magazi ndi mkodzo - kudziwa zambiri za thupi,
• lipidogram - kafukufuku wathunthu wokhudzana ndi kuchuluka kwa mafuta a metabolism m'thupi ndi kutsimikiza kwa cholesterol yathunthu, zigawo zake za atherogenic ndi antiatherogenic, triglycerides ndi chiopsezo cha zovuta zamatenda a mtima komanso matenda a mtima.
• kusanthula kwa zamankhwala amodzi, kuphatikiza kutsimikiza: bilirubin kwathunthu komanso mwachindunji, AlAT ndi AsAT, KFK, creatine ndi urea kuti mupeze impso.

Ngati mayeso awa ali mkati moyenera, ndiye kuti palibe zotsutsana ndi ma statins. Pakatha mwezi kuyambira chiyambi cha mankhwalawa, kuchuluka konse kwa mayeso kuyenera kubwerezedwanso kuti mudziwe njira zamachitidwe ena. Ngati mayeso onse ali mkati moyenera, ndiye kuti ma statin ndi oyenera kuti wodwalayo azitsitsa cholesterol, ndikuchita zabwino kuposa kuvulaza.

Ngati, pakuwunikira kosamalira, odwala akuwonetsa kuphwanya chiwindi, minofu yamatumbo kapena impso, chithandizo cha statin chimapweteketsa kuposa chabwino.

Madera: Zabwino ndi Zabwino

Ngakhale pali mkangano wazomwe zasayansi, zomwe zikadali zopezekanso: zabwino kapena zoyipa, madokotala tsiku lililonse amapereka mankhwalawa kwa ambiri omwe ali ndi cholesterol yayikulu. Ubwino ndi kuipa kwa kutenga HMG CoA reductase inhibitors zaperekedwa mu tebulo ili m'munsiyi.

"Za" kutenga ma statins

“Potsutsa” kugwiritsa ntchito ma statin

lawani cholesterol, ndikuchepetsa kwambiri mwezi woyamba wamankhwalaosayenera kwa odwala omwe ali ndi matenda osatha a chiwindi: amatha kuyambitsa necrosis yayikulu ya hepatocytes ndi kulephera kwa chiwindi Kuchepetsa chiwopsezo cha matenda a mtima ndi dyscirculatory encephalopathy mwa athanzi odwala omwe ali ndi cholesterol yayikulukhalani ndi zovuta zingapo zoyipa, kuphatikiza zovulaza thupi Kuchepetsa chiopsezo chakupha cha mtima ndi matenda a m'matumbo mwa odwala omwe ali ndi 25-25%Zotsatira zoyipa ndi 0.3-2% Kuchepetsa kufa kwa matenda a mtima ndi sitirokosangathe kugwiritsidwa ntchito ndi amayi apakati, oyembekezera kuyamwa ndi ana osakwana zaka 10 mankhwalawa moyenera mitundu ya hypercholesterolemiaamafunika kugwiritsa ntchito nthawi yayitali (miyezi ngakhale zaka), pomwe chiwopsezo cha zotsatira zoyipa chikukula yosavuta kugwiritsa ntchito: muyenera kumwa kamodzi kokha patsikumusamayende bwino ndimankhwala ena Yabwino mankhwalawa atherosulinosis odwala matenda a impso: owonjezeredwa makamaka ndi chiwindi nthawi zambiri amavomerezedwa ndi odwala, kuphatikizapo okalamba

Pambuyo poti ma statins adayambitsidwa machitidwe azachipatala ndikuyamba kugwiritsidwa ntchito kwambiri, kuphedwa kwa mtima komanso matenda amisala amitsempha yam'magazi kunatsika ndi 12-14%. Ku Russia, izi zikutanthauza kuti pafupifupi anthu 3,000,000 amapulumutsa chaka chilichonse.

Cholesterol chotani choti mutenge ma statins

Miyezo ya cholesterol imatsimikiza pogwiritsa ntchito kuyezetsa magazi. M'pofunika kuchitira izi kwa anthu akulu akulu: amuna pambuyo pa zaka 35 ndi azimayi omwe afika msambo. Gulu lowopsa lomwe limakhala ndi anthu odwala matenda a shuga, matenda oopsa komanso onenepa kwambiri komanso osafuna kusuta.

Zowonjezera zake ndi 200 mg / dl. Malinga ndi ziwerengero, avareji ya Russia imafika 240-250 mg / dl. Komabe, izi sizoyenera, zimangofunika kusintha mtundu wa chakudya ndi moyo. Pa 250 mg / dl, mankhwala osokoneza bongo ndi osankha.

Nanga ndi cholesterol iti yomwe imatenga ma statins osati zotheka, komanso zofunika? Pa mulingo wa 270-300 mg / dl, kakhazikikidwe ka chithandizo kakhalira. Potere, palibe moyo wathanzi, kapena chakudya chokhwima kapena chokhwima sichingakuthandizeni. Kwa odwala omwe achulukitsa mitengo, mthandizi wamphamvu wamtundu wa mankhwala amafunikira.

Simvastatin

Mankhwala ndimibadwo. Zomwe zimapangidwira zimatengera chinthu chimodzi chomwe chimagwira. Amawerengera Hypercholesterolemia.

Amapezeka mu mapiritsi a 10 ndi 20 mg. Mtengo wapakati uli mgulu la ma ruble 100 pama mapiritsi 30 (opangidwa ku Russia) komanso m'chigawo cha rubles 210 cha "Simvastatin" chopangidwa ku Serbia.

"Rosuvastatin"

Amawerengedwa ngati mankhwala amphamvu kwambiri m'badwo wachinayi. Amapezeka mu mapiritsi okhala ndi 5, 10, 20 ndi 40 mg yogwira mtima. Mtengo umatengera mlingo ndipo umachokera ku 205 mpaka 1750 rubles.

Tengani ma statins a cholesterol, maubwino ndi zopweteketsa zina mwa njira zoyipa ndizotsatira zamankhwala. Ndikofunikira kukonzekera kuti chithandizo chotsatira chikhale ndi zotsatira zoyipa monga:

• mutu
• kudzimbidwa
• kupweteka kwa minofu,
• kukula kwa thupi lawo siligwirizana (chizindikiro chofala kwambiri ndi zotupa pakhungu).

Nthawi zina, kusokonezeka kwambiri kwa chiwindi kumachitika.

Momwe mungatenge ma statins a cholesterol

Kulandila kumaloledwa kokha monga momwe dokotala wanenera! Momwe mungamwe ma cholesterol, mu kuchuluka komanso kwa nthawi yayitali, akuyenera kutsimikizidwanso ndi dokotala potengera momwe wodwalayo alili.

Maphunziro oyamba nthawi zambiri amayamba ndi kuchuluka kwa 5-10 mg kamodzi patsiku, piritsi liyenera kutsukidwa ndi madzi ambiri. Kukula kwa Mlingo ndikotheka patatha mwezi umodzi.

Mwezi uliwonse cheke chomwe chimakonzedwa chimachitika, malinga ndi zotsatira za kusanthula, mlingo umatsika kapena ukuwonjezeka. Kutalika kwa chithandizo kumatenga nthawi yayitali. Kutalika kochepa kwa maphunziro a mankhwala ndi miyezi 1-2. Odwala ena amafunikira mankhwala okhalitsa.

Momwe mungasinthire ma statins kuti muchepetse cholesterol

Mutha kugwiritsa ntchito osati ma statin okha. Tikulankhula za chithandizo chamankhwala ndi chibwenzi cha anthu. Choyamba, muyenera kuyamba kudya bwino. Ndikulimbikitsidwa kuthetseratu mafuta, okazinga. Onetsetsani kuti mukuwonjezera m'dera lanu:

Makamaka chidwi chake chikuyenera kulipidwa kwa ma prunes ndi mtedza - ndiwofunika kwambiri ngati chovutikira ndipo nthawi yomweyo ndi omenyera mwamphamvu mapangidwe a cholesterol plaques.

Ndipo momwe mungasinthire ma statins kuti muchepetse cholesterol ku mankhwala?

1. Fibroic acid. Kukonzekera komwe kumakhala ndi Fibroic acid kumaphatikizapo clofibrate, fenofibrate, ndi gemfmbrozil. Mukamamwa mankhwalawa, zotumphukira m'mimba zimatheka.
2. Bile Acid Mwa mankhwala othandiza kwambiri omwe ali ndi bile acid olembedwa "Colestid" ndi "Questran." Zitha kugwiritsidwa ntchito ngati chithandizo chamankhwala komanso ngati njira yothandizira. Zovuta zake zimaphatikizira kuwuma komanso kusasangalala pamimba panthawi yamankhwala.

Ndikofunika kukumbukira kuti chithandizo chilichonse chimaloledwa pokhapokha atakambilana ndi dokotala!

Dr. Myasnikov pa cholesterol ndi ma statins, ndemanga yamavidiyo

Ph.D. in Medicine, dokotala wazamankhwala ku United States of America, dotolo wamkulu wa State Clinical Hospital N ° 71 Alexander Myasnikov adanena malingaliro ake pazomwe ma statins ali a cholesterol, maubwino ndi kuvulaza kwa iwo. Dr. Myasnikov akuti mosiyana ndi zomwe ambiri amakhulupirira, ma statin siwopanda chifukwa sangathe kuyamwa cholesterol! Mankhwala amangoletsa mawonekedwe ake.

Mankhwalawa amathandizira kupewa matenda a mtima mwa odwala, amalimbitsa mafupa, komanso kupewa mapangidwe a matenda a ndulu ndi mitundu ina ya khansa. Dr. Myasnikov akuti ntchito yama statins ndi momwe zimakhudzira thupi la munthu sizinaphunzire konse. Amanenanso kuti mankhwalawa amathandizira osati kulimbitsa khoma lamitsempha, komanso kupewa kupewa njira zotupa komanso kupitilira kwa matenda. Kuvuta kwamankhwala kumachitika chifukwa chakuti nthawi zambiri muyenera kumwa mankhwala tsiku lililonse, m'moyo wanu wonse.

Dr. Myasnikov wokhudza cholesterol ndi ma statins, chiwembu cha kanema:

Popeza tazindikira mwatsatanetsatane zomwe ma statins amachokera ku cholesterol, maubwino ndi kuwonongeka kwawo, komanso ndi zina zachilengedwe, titha kunena motsimikiza kuti cholesterol yapamwamba m'magazi si chiganizo! Mutha kulimbana nawo, komanso mtengo wokwera bwino kwambiri. Komanso, matendawa amatha kupewedwa ndi prophylactic mankhwala. Ndemanga pamutuwu mutha kuwerengera kapena kulembedwa pagawoli pamankhwala azithandizo za anthu