Protafan nm malangizo ogwiritsa ntchito, contraindication, mavuto, ndemanga

Protafan ® HM Penfill ®

Kutulutsa mawonekedwe Protafan nm penfill, ma CD ndikuphatikizira ndi mankhwala.

Kuyimitsidwa kwa mtundu wa yoyera, ikaphatikizika, imakhala yoyera komanso yopanda utoto, yopatsa chidwi, yolowera iyenera kukhazikikanso.

1 ml
isofan insulin (umisiri wa majini a anthu)
100 IU *

Omwe amathandizira: zinc chloride, glycerol, metacresol, phenol, sodium hydrogen phosphate dihydrate, protamine sulfate, hydrochloric acid ndi / kapena sodium hydroxide solution (kukonza pH), madzi d / ndi.

* 1 IU imafanana ndi 35 μg ya insulin ya munthu wosafunikira.

3 ml - makatoni amtundu osavala magalasi (5) - matuza (1) - mapaketi a makatoni.

Kufotokozera kwa ZOTHANDIZA ZABWINO.
Zonse zomwe zaperekedwa zimangoperekedwa kuti mudziwe bwino za mankhwalawo, muyenera kufunsa dokotala zokhudzana ndikugwiritsa ntchito.

Momwe mungagwiritsire ntchito Protafan?

Mlingo wa insulin ndi munthu payekha ndipo amatsimikiza ndi dokotala mogwirizana ndi zosowa za wodwala.

Pafupifupi, tsiku lililonse zofunika kuti insulini igwiritsidwe ntchito pochotsa matenda ashuga kuyambira 0,5 mpaka 1.0 IU / kg thupi. Mwa ana otsogola, zimasiyana kuchokera pa 0.7 mpaka 1.0 IU / kg. Panthawi yachikhululukiro chochepa, kufunika kwa insulini kumatha kuchepetsedwa, pomwe milandu ya insulin ikulimbana, mwachitsanzo, nthawi yakutha kapena kunenepa kwambiri, kufunikira kwa insulin tsiku ndi tsiku kumatha kuchuluka kwambiri.

Mlingo woyambirira wa insulin kwa odwala omwe ali ndi matenda a shuga a 2 nthawi zambiri amakhala otsika, mwachitsanzo, kuyambira 0,3 mpaka 0,6 IU / kg / tsiku.

Dokotalayo amawona kuchuluka kwa jakisoni patsiku (imodzi kapena zingapo) zomwe wodwala amafunikira. Protafan imatha kuperekedwa yokha kapena kusakanizidwa ndi insulin yothamanga. Pakulimbitsa insulin kwambiri, kuyimitsidwa kumagwiritsidwa ntchito ngati basal insulin, yomwe imayendetsedwa usiku ndi / kapena m'mawa, ndipo insulin yofulumira imathandizidwa musanadye.

Kukhazikitsa kagayidwe kachakudya mu shuga odwala amachedwetsa kuyambirako ndikuchepetsa kukula kwa zovuta za matenda ashuga. Chifukwa chake, kuyang'anira kuchuluka kwa shuga m'magazi tikulimbikitsidwa.

Odwala okalamba komanso osachiritsika, cholinga choyamba cha mankhwalawa ndikuchepetsa zizindikiro za matenda ashuga komanso kupewa kukula kwa hypoglycemia.

Protafan NM adapangira jakisoni wofikira.

Protafan HM nthawi zambiri imayendetsedwa pansi pa khungu la ntchafu. Mutha kulowanso m'dera la khoma lamkati, matako kapena minyewa yolimba ya phewa.

Ndi jakisoni wothira mkati mwa ntchafu, kuyamwa kwa insulini kumayamba pang'onopang'ono kuposa ndikabayidwa mbali zina za thupi.

Kukhazikitsidwa kwa khola lakukhazikika kwa khungu kumachepetsa chiopsezo chofika minofu.

Popewa jakisoni wa jekeseni, malo ayenera kusinthidwa ngakhale mkati momwe.

Palibe chifukwa chilichonse ngati insulin kuyimitsidwa iyenera kuperekedwa.

Zotsatira za pharmacological

Amalumikizana ndi membrane membrane wa plasma ndikulowa mu cell, momwe imayambitsa phosphorylation ya mapuloteni am'magazi, imalimbikitsa glycogen synthetase, pyruvate dehydrogenase, hexokinase, inhibits minofu ya lipip ndi lipoprotein lipase. Kuphatikiza ndi cholandilira china chake, chimathandizira kulowa kwa glucose m'maselo, kumathandizira kukoka kwake ndi minofu ndikulimbikitsa kutembenuka kukhala glycogen. Kuchulukitsa minofu ya glycogen, kumapangitsa kaphatikizidwe ka peptide.

Clinical Pharmacology

Zotsatira zimayambika maola 1.5 pambuyo poyang'anira sc, zimafika patadutsa maola 4-12 ndipo zimatha maola 24. Protafan NM Pulogalamu yodwala matenda a shuga omwe amadalira insulin amagwiritsidwa ntchito ngati insulin insulin limodzi ndi insulin yotsalira, kwa osagwirizana ndi insulini - monga monotherapy , komanso kuphatikiza ma insulini othamangira mwachangu.

Kuchita

Zotsatira za hypoglycemic zimapangidwira ndi acetylsalicylic acid, mowa, alpha ndi ma beta blockers, amphetamine, anabolic steroids, clofibrate, cyclophosphamide, phenfluramine, fluoxetine, ifosfamide, MAO zoletsa, methyldopa, tetracycline, trifamazidigigidi, trifamizidigigidi, trifamizidigigidi, trifamizigidigigidi, trifamizigidigigidi, trifamigidigigidi, trifamigidigigidi, trifamizigigidi, trifamigidigigidi, trifamizigidigigidi, trifamizigigidi, trifamizigigidi, trifamizigidigigidi, trifamizigigidi. thiazides), glucocorticoids, heparin, kulera kwa mahomoni, isoniazid, lithiamu carbonate, nicotinic acid, phenothiazines, audiathomimetics, tricyclic antidepressants.

Mlingo ndi makonzedwe

Protafan ® HM Penfill ®

P / c. Mankhwala adapangira subcutaneous makonzedwe. Kuyimitsidwa kwa insulin sikungalowe / kulowa.

Mlingo wa mankhwalawa amasankhidwa payekha, poganizira zosowa za wodwala. Nthawi zambiri, zofunika za insulin zimakhala pakati pa 0.3 ndi 1 IU / kg / tsiku. Kufunika kwa insulin tsiku lililonse kumatha kukhala kwabwino kwambiri kwa odwala omwe ali ndi insulin (mwachitsanzo, nthawi yakutha msinkhu, komanso odwala omwe ali ndi kunenepa kwambiri), komanso otsika mwa odwala omwe ali ndi zotsalira za insulin.

Protafan ® NM itha kugwiritsidwa ntchito pa monotherapy komanso kuphatikiza mwachangu kapena mwachidule.

Protafan ® NM nthawi zambiri imayendetsedwa mwachangu mu ntchafu. Ngati ndi yabwino, ndiye kuti jakisoni amathanso kuchitika khoma lakunja kwamkati, m'chigawo cha gluteal kapena m'dera la minofu ya m'mapazi. Ndi kukhazikitsidwa kwa mankhwalawa mu ntchafu, pali kuyamwa pang'onopang'ono kuposa komwe kumayambitsidwa m'malo ena. Ngati jakisoniyo wapangidwira pakhungu lalitali, ngozi ya mankhwalawo mwangozi imachepetsedwa.

Singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera, omwe amatsimikizira mlingo wokwanira. Ndikofunikira nthawi zonse kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Protafan ® NM Penfill ® idapangidwa kuti igwiritsidwe ntchito ndi NOvo Nordisk insulin jakisoni ndi singano za NovoFine ® kapena NovoTvist ®. Malangizo atsatanetsatane ogwiritsira ntchito ndi kuyang'anira mankhwalawa amayenera kuonedwa.

Matenda okhala ndi vuto limodzi, makamaka opatsirana komanso kutentha thupi, nthawi zambiri amalimbikitsa kufunika kwa insulin. Kusintha kwa magazi kungafunikenso ngati wodwala ali ndi matenda a impso, chiwindi, mkhutu wa adrenal ntchito, pituitary gland kapena chithokomiro cha chithokomiro. Kufunika kosinthidwa kwa mlingo kumatha kuonekanso posintha zolimbitsa thupi kapena zakudya zomwe wodwala amadya. Kusintha kwa Mlingo kungafunike posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina

Bongo

Zizindikiro Kukula kwa hypoglycemia (thukuta lozizira, palpitations, kugwedezeka, kugona, kukwiya, kusokonekera, pallor, kupweteka mutu, kugona, kusowa poyenda, kuyankhula ndi kuwonongeka kwamaso, kukhumudwa). Hypoglycemia imatha kubweretsa kuwonongeka kwakanthawi kapena kugwira ntchito kwa ubongo, chikomokere, ndi kufa.

Chithandizo: shuga kapena shuga mkati mwake (ngati wodwalayo akudziwa), s / c, i / m kapena iv - glucagon kapena iv - glucose.

Mitengo mumaofesi a mankhwala ku Moscow

Zomwe zimaperekedwa pamitengo yamankhwala si kupatsa kapena kugulitsa zinthu.
Chidziwitsochi cholinga chake ndi kuyerekezera mitengo yamafesi apamtunda yomwe ikuyenda molingana ndi Article 55 ya Federal Law "On the Circulation of Medicines" ya 12.04.2010 N 61-ФЗ.

Pharmacokinetics

Hafu ya moyo wa insulini kuchokera m'magazi ndi mphindi zochepa chabe.

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo wa insulin, njira ndi malo oyendetsera, makulidwe a subcutaneous mafuta wosanjikiza ndi mtundu wa matenda osokoneza bongo). Chifukwa chake, magawo a pharmacokinetic a insulin ali ndi kusinthasintha kwakukulu kwapakati pa intaneti ndi munthu payekha.

Kuzindikira ndende (C_max) insulin ya plasma imafikiridwa patangotha ​​maola 2-18 pambuyo povomerezeka.

Palibe zomangamanga zomanga mapuloteni a plasma zimadziwika, kupatulapo ma antibodies a insulin (ngati alipo).

Insulin yaumunthu imapukusidwa ndi zochita za insulin proteinase kapena ma enzyme okhala ndi insulini, ndipo mwina mwa mapuloteni omwe amachititsa kuti mapuloteni azikhala asomerase. Amaganiziridwa kuti mu molekyulu ya insulin ya anthu pali malo angapo a cleavage (hydrolysis), komabe, palibe amodzi a metabolites omwe amapangidwa chifukwa cha cleavage akugwira ntchito.

Hafu ya moyo (T_½) chimadziwika ndi kuchuluka kwa mayamwidwe subcutaneous minofu. Chifukwa chake T_½ m'malo mwake, ndi gawo la mayamwidwe, ndipo osati makamaka muyeso wochotsa insulini kuchokera ku plasma (T_½ insulin yochokera m'magazi ndi mphindi zochepa chabe). Kafukufuku wasonyeza kuti T_½ pafupifupi maola 5-10.

Deta Yotetezera

M'maphunziro a preclinical, kuphatikizapo maphunziro a chitetezo cha pharmacological, maphunziro a kawopsedwe omwe ali ndi Mlingo wambiri, maphunziro a genotoxicity, chiwopsezo cha carcinogenic komanso zotsatira zoyipa pamagawo obala, palibe vuto lililonse kwa anthu lomwe linadziwika.

Mimba komanso kuyamwa

Palibe choletsa kugwiritsa ntchito insulin panthawi yapakati, popeza insulin siyidutsa chotchinga.

Onsewa a hypoglycemia ndi hyperglycemia, omwe amatha kukhala ndi vuto losankha bwino, amalimbikitsa chiopsezo cha kusokonezeka kwa fetal ndi kufa kwa fetal. Amayi oyembekezera omwe ali ndi matenda ashuga amayenera kuyang'aniridwa panthawi yonse yomwe ali ndi pakati, ayenera kuti amawongolera kuchuluka kwa shuga wamagazi, malingaliro omwewo amagwiranso ntchito kwa amayi omwe akukonzekera kutenga pakati.

Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu.

Pambuyo pobadwa mwana, kufunika kwa insulin, monga lamulo, kumabwereranso msanga pazomwe zimawonedwa musanakhale ndi pakati.

Palibenso zoletsa kugwiritsa ntchito mankhwalawa Protafan® NM pa nthawi ya mkaka. Kuchita insulin kwa amayi oyamwitsa sikowopsa kwa mwana. Komabe, mayi angafunike kusintha njira ya Protafan® NM ndi / kapena zakudya.

Zotsatira zoyipa

Chochitika chovuta kwambiri chambiri ndi insulin ndi hypoglycemia. Pa maphunziro azachipatala, komanso munthawi yogwiritsira ntchito mankhwalawa atamasulidwa pamsika waogula, zidapezeka kuti kuchuluka kwa hypoglycemia kumasiyana malinga ndi kuchuluka kwa odwala, kuchuluka kwa mankhwalawa, komanso kuchuluka kwa kayendedwe ka glycemia (onani. "Kufotokozerazosintha zimasiyana ").

Pa gawo loyambirira la insulin, zolakwika zotupa, edema ndi zimachitika zimapezeka pamalo a jakisoni (kuphatikiza ululu, kufiyira, ming'oma, kutupa, kuphwanya, kutupa ndi kuyunkhira pamalo a jekeseni. Zizindikirozi nthawi zambiri zimakhala zakanthawi. Kusintha kwapang'onopang'ono pakuwongolera glycemic kumatha kubweretsa mkhalidwe wa "ululu wammbuyo wamitsempha," womwe umatha kusintha. Kulimbitsa kwa insulin mankhwala ndikusintha kolimba kwa mphamvu ya kagayidwe kazakudya kungayambitse kuwonongeka kwakanthawi mu matenda a shuga, pomwe kusintha kwakanthawi kwakanthawi ka glycemic kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy.

Mndandanda wazotsatira zoyipa zimaperekedwa pagome.

Zotsatira zonse zoyipa zomwe zaperekedwa pansipa, kutengera data kuchokera ku mayeso azachipatala, zimayikidwa m'magulu molingana ndi kukula kwa chitukuko malinga ndi MedDRA ndi kachitidwe ka ziwalo. Zotsatira zoyipa zimafotokozedwa ngati: pafupipafupi (≥ 1/10), nthawi zambiri (≥ 1/100 to

Njira zopewera kupewa ngozi

Hypoglycemia imatha kukhazikika ngati insulin yapamwamba kwambiri imaperekedwa poyerekeza ndi zosowa za wodwala.

Kudumpha zakudya kapena kuchita masewera olimbitsa thupi mosakonzekera kungayambitse matenda a hypoglycemia.

Pambuyo kulipirira kagayidwe kazakudya, mwachitsanzo, ndi mankhwala olimbitsa kwambiri a insulin, odwala amatha kukumana ndi zisonyezo zam'mbuyomu za hypoglycemia, zomwe odwala ayenera kudziwitsidwa. Zizindikiro zachilendo zimatha kutha ndi matenda a shuga.

Kusamutsa odwala ku mtundu wina wa insulin kapena insulin ya wopanga wina uyenera kuchitika kokha moyang'aniridwa ndi achipatala. Ngati musintha ndende, mtundu wa opanga, mitundu (insulin ya anthu, analog ya insulin ya anthu) ndi / kapena njira yopangira, mungafunike kusintha mlingo wa insulin. Odwala omwe akuchipatala ndi Protafan® NM angafunike kusintha kwa jekeseni kapena kuwonjezeka kwa jekeseni poyerekeza ndi zomwe anakonzera insulin kale. Ngati kusintha kwa mlingo kuli kofunikira posamutsa odwala kuti alandire chithandizo ndi Protafan® NM, izi zitha kuchitika kale pokhazikitsidwa kwa woyamba kapena mu masabata oyamba kapena miyezi ya chithandizo.

Monga mankhwala ena a insulin, zimachitika mu jakisoni wa jekeseni, yomwe imawonetsedwa ndi kupweteka, kufiyira, ming'oma, kutupa, kutupa, kutupa ndi kuyabwa. Kusintha pafupipafupi jekeseni pamalo omwewo anatithandizanso kuthandizira kuchepetsa zizindikiritso kapena kuletsa kukula kwa izi. Kuchitidwa nthawi zambiri kumatha patatha masiku angapo mpaka milungu ingapo. Mwakamodzikamodzi, kuleka kwa Protafan® NM kungakhale kofunikira chifukwa cha zomwe zimachitika jekeseni.

Asanayende ndikusintha kwa magawo a nthawi, wodwalayo ayenera kufunsa dokotala, chifukwa kusintha nthawi kumatanthauza kuti wodwalayo ayenera kudya ndikupereka insulin panthawi ina.

Kuyimitsidwa kwa insulin sikungagwiritsidwe ntchito pamapampu a insulin.

Kugwiritsa ntchito munthawi yomweyo mankhwala a gulu la thiazolidinedione komanso kukonzekera insulin

Milandu yokhudzana ndi kukhazikika kwa mtima wosakanika wafotokozedwanso chithandizo cha odwala omwe ali ndi thiazolidinediones osakanikirana ndi insulin, makamaka ngati odwala oterewa ali pachiwopsezo cha kukula kwa mtima wovuta. Izi zimayenera kukumbukiridwa popereka mankhwala ophatikiza ndi thiazolidatediones ndi insulin yokonzekera odwala.Mukamapereka mankhwala othandizira, muyenera kuyesa mayeso a madokotala kuti muwone ngati ali ndi vuto la mtima, kuchuluka kwa thupi ndi kupezeka kwa edema. Ngati zizindikiro za kulephera kwa mtima zikuchulukirachulukira kwa odwala, chithandizo ndi thiazolidatediones ziyenera kusiyidwa.

Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu

Kuthekera kwa odwala kulolera komanso kuchuluka kwa momwe angachitire amatha kusokonezeka panthawi ya hypoglycemia, zomwe zimakhala zowopsa nthawi zomwe maluso amenewa amafunikira makamaka (mwachitsanzo, poyendetsa galimoto kapena kugwira ntchito ndi makina ndi makina).

Odwala ayenera kulangizidwa kuti achitepo kanthu popewa kukula kwa hypoglycemia mukamayendetsa galimoto. Izi ndizofunikira kwambiri kwa odwala omwe alibe kapena kuchepetsedwa Zizindikiro zakutsogolo kwa hypoglycemia kapena akuvutika ndi zochitika zapafupipafupi za hypoglycemia. Muzochitika izi, kuyendetsa bwino ndikuchita ntchito yotereyi kuyenera kuganiziridwa.

Malo osungira

Kutentha kwa 2 ° C mpaka 8 ° C (mufiriji), koma osati pafupi ndi mufiriji. Osamawuma.

Sungani makatoni makatoni kuti muteteze.

Pa makatiriji otseguka: Osasunga mufiriji. Sungani kutentha osapitirira 30 ° C milungu isanu ndi umodzi.

Protafan ® NM Penfill ® iyenera kutetezedwa ku kutentha kwakukulu ndi kuwala.

Pewani kufikira ana. Pewani kufikira ana.

Malangizo kwa wodwala

Protafan NM mu mbale imagwiritsidwa ntchito ndi ma syringes apadera, omwe ali ndi maphunziro oyenera. Mankhwalawa adapangira kuti aliyense azigwiritsa ntchito.

Musanagwiritse ntchito mankhwala a Protafan NM, muyenera kuwonetsetsa kuti ndiomwe mtundu wa insulin womwe umakhazikitsidwa. Ndikofunikira kupha tiziromboti pamtunda pa mphira ya mphira.

Wodwala akangogwiritsa ntchito Protafan NM:

• Musanagwiritse ntchito, guditsani botolo la insulin pakati pa manja anu mpaka madziwo atasanduka oyera ndi mitambo.
• Sungani kuchuluka kwa mpweya wofanana ndi mlingo wa insulin womwe umalowa mu syringe.
• Lowetsani mpweya mu botolo.
• Tembenuza vial ndi syringe pansi.
• Sungani kuchuluka kwa insulin mu syringe.
• Chotsani singano mu vial.
• Tsitsani mpweya kuchokera ku syringe.
• Onani ngati mulingo woyamwa walowetsedwa molondola.
• Pangani jakisoni nthawi yomweyo.

• Nthawi yomweyo musanagwiritse ntchito, yokulungira pakati pa kanjedza ka botolo ndi Protafan NM mpaka madzi atasanduka oyera ndikukhala ngati mitambo.
• Jambulani mu syringe voliyumu ya mpweya wofanana ndi mlingo wa Protafan NM. Lowetsani mpweya mu vial ndi Protafan NM ndikuchotsa singano mu vial.
• Jambulani mpweya wofanana ndi muyezo wa insulini yochepa. Lowetsani mpweya mu insulin vial. Tembenuza vial ndi syringe pansi.
• Jambulani kuchuluka kwa insulin yomwe yatsala pang'ono kulowa mu syringe. Chotsani singano mu vial. Tsitsani mpweya kuchokera ku syringe. Onani ngati mulingo woyamwa walowetsedwa molondola.
• Ikani singano mu botolo ndi Protafan NM. Tembenuza vial ndi syringe pansi.
• Ikani muyezo wofunikira wa Protafan NM mu syringe. Chotsani singano mu vial. Tsitsani mpweya kuchokera ku syringe ndikuwonetsetsa ngati mlingo wake wakhazikika.
• Nthawi yomweyo jekesani zosakaniza.
• Nthawi zonse muzisakaniza kwa insulin pang'ono komanso nthawi yayitali.

Momwe mungapangire insulin

Vulani khungu ndi zala ziwiri, ikani singano mu khola la khungu ndikupanga jakisoni wokhazikika wa insulin.

Gwirani singano pansi pakhungu kwa mphindi zosachepera 6 kuti muwonetsetse kuti insulini yonse ilowa.

Mlingo wosakwanira kapena kusiya kulandira chithandizo (makamaka ndi matenda amtundu 1) kungayambitse matenda a hyperglycemia ndi matenda ashuga a ketoacidosis. Nthawi zambiri, zizindikiro zoyambirira za hyperglycemia zimayamba pang'onopang'ono kwa maola angapo kapena masiku. Izi ndi monga: ludzu, kukokana pafupipafupi, nseru, kusanza, kugona komanso kuyanika pakhungu, pakamwa pouma, kusowa chilimbikitso, komanso kununkhira kwa acetone mumlengalenga wotuluka (onani gawo la zotsatira zoyipa).

Mtundu woyamba wa matenda ashuga, hyperglycemia yopanda matenda imatsogolera ku matenda ashuga a ketoacidosis, omwe amapha kwambiri.

Hypoglycemia imatha kuchitika ngati mlingo wa insulin uposa kufunika kwake. Mokulira, hypoglycemia imatha kuthandizidwa ndikuyamba kupezeka kwa chakudya. Odwala ayenera kuchita izi nthawi yomweyo, motero amalangizidwa kuti azikhala ndi glucose nthawi zonse.

Kudumpha zakudya kapena kuchita masewera olimbitsa thupi mosayembekezereka kungayambitse hypoglycemia.

Odwala omwe atukula kwambiri kuchuluka kwa shuga m'magazi chifukwa chokhudza insulin yokwanira amatha kuwona kusintha kwa chizolowezi chawo, okhazikika a hypoglycemia, omwe ayenera kuchenjezedwa pasadakhale (onani gawo la Zotsatira zoyipa).

Zizindikiro zachilendo zimatha kutha mwa anthu omwe ali ndi matenda ashuga kwa nthawi yayitali.

Matenda obvuta, makamaka matenda ndi kutentha thupi, nthawi zambiri zimawonjezera kufunikira kwa insulin.

Kulephera kwamkati kapena chiwindi kungayambitse kuchuluka kwa insulin.

Kufunika kokhazikika kwa kuchuluka kwa insulini kungachitike ngati odwala akuwonjezera zolimbitsa thupi kapena kusintha zakudya zomwe amakonda.

Kusamutsa wodwala kupita ku mtundu wina kapena mtundu wa insulin kumachitika moyang'aniridwa ndi achipatala. Zosintha mu ndende, mtundu (wopanga), mtundu (insulin yothamanga, biphasic insulin, insulin yayitali), chiyambi cha insulin (chinyama, chaumunthu kapena chaumwini cha insulin) ndi / kapena njira yopangira (DNA yongofanananso ndi insulin) ingafunike kukonza Mlingo wa insulin. Mukasamutsa wodwala jakisoni wa Protafan NM, pangafunike kusintha mtundu wa insulin. Kufunika kwa kusankha kwa mankhwalawa kumatha kuchitika pakangoyamba kwa mankhwala atsopano, komanso pakatha milungu ingapo kapena miyezi yambiri yogwiritsidwa ntchito.

Odwala ena omwe adakumana ndi vuto la hypoglycemic atasintha kuchokera ku nyama kupita ku insulin ya anthu adazindikira kufooka kapena kusintha kwa zizindikiro zakutsogolo kwa hypoglycemia.

Asanayende m'malo osiyanasiyana, odwala ayenera kufunsa dokotala, chifukwa izi zimasintha jakisoni wa insulin komanso kudya.

Kuyimitsidwa kwa insulin sikungagwiritsidwe ntchito pamapampu a insulini kupitiliza kuperekera insulin.

Protafan HM imakhala ndi metacresol, yomwe imatha kuyambitsa thupi.

Mimba komanso kuyamwa

Chifukwa insulin siidutsa chotchinga, palibe malire ku chithandizo cha matenda ashuga omwe ali ndi insulin panthawi yapakati. Ndikulimbikitsidwa kumalimbitsa kuwongolera pochiza amayi apakati omwe ali ndi matenda ashuga nthawi yonse yomwe ali ndi pakati, komanso pazochitika zomwe akuganiza kuti ali ndi pakati, popeza chifukwa chosayang'anira shuga, onse hypoglycemia ndi hyperglycemia amawonjezera chiopsezo cha kusokonezeka kwa fetal ndi kufa.

Kufunika kwa insulin nthawi zambiri kumachepa mu trimester yoyamba ya kutenga pakati ndikuwonjezeka kwambiri mu trimesters yachiwiri ndi yachitatu.

Pambuyo pobadwa, kufunikira kwa insulin kumabweza msanga.

Palibenso zoletsa zina pa chithandizo cha matenda ashuga omwe ali ndi insulin nthawi yoyamwitsa, chifukwa chithandizo cha mayi sichikhala pachiwopsezo kwa mwana. Komabe, kusintha kwa mankhwalawa kungakhale kofunikira.

Kukopa pa luso loyendetsa magalimoto ndi zida.

Kuyankha kwa wodwalayo komanso kuthekera kwake kochita chidwi kukhoza kukhala ndi vuto la hypoglycemia. Izi zitha kukhala zowopsa nthawi zomwe maluso amenewa ali ofunikira (mwachitsanzo, poyendetsa galimoto kapena makina).

Odwala ayenera kulangizidwa kuti azichita zinthu zoteteza hypoglycemia musanayendetse. Izi ndizofunikira kwambiri kwa odwala omwe afooka kapena kupezeka zizindikiro za kutsogola kwa hypoglycemia, kapena zochitika za hypoglycemia zimachitika pafupipafupi. Zikatero, funso lofunsa kuyendetsa bwino kwambiri liyenera kuthetsedwa.

Kusagwirizana

Monga lamulo, insulini imatha kuwonjezeredwa pazinthu zomwe kuphatikizika kwake kumadziwika. Kuyimitsidwa kwa insulin sikuyenera kusakanikirana ndi kulowetsedwa. Mankhwala omwe amawonjezeredwa pakuyimitsidwa kwa insulin angayambitse kuwonongeka kwake, mwachitsanzo, kukonzekera komwe kumakhala ndi thiols kapena sulfites.

Protafan NM Penfil - makatoni atatu a 3 ml opangidwa kuti azigwiritsidwa ntchito ndi zolembera za Novo Nordisk insulin ndi singano za NovoFayn. Makatoni amayenera kugwiritsidwa ntchito ndi zolembera za syringe zomwe zimagwirizana nawo ndikuwonetsetsa kuti chitetezo chimagwiritsidwa ntchito.

Mlingo wa insulin ndi munthu payekha ndipo amatsimikiza ndi dokotala mogwirizana ndi zosowa za wodwala.

Pafupifupi, kufunikira kwa insulin tsiku lililonse pochiza matenda ashuga kumayambira pa 0.5 mpaka 1.0 IU / kg kapena kupitilira, kutengera mkhalidwe wa wodwala aliyense.

Mlingo ndi njira ya mankhwala.

Lowani s / c, nthawi 1-2 / tsiku, mphindi 30-45 musanadye chakudya cham'mawa. Tsamba la jakisoni liyenera kusinthidwa nthawi iliyonse. Mwapadera, kuyambitsa / m ndikotheka.

Mu / pakubweretsa insulin ya nthawi yayitali sikuloledwa.

Mlingo umayikidwa payekha, kutengera zomwe zili ndi shuga m'magazi ndi mkodzo, mawonekedwe a matendawa.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere.

Pa nthawi ya pakati, ndikofunikira kuganizira za kuchepa kwa insulin mu trimester yoyamba kapena kuwonjezeka kwa trimesters yachiwiri ndi yachitatu. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Pa mkaka wa m`mawere, kuwunikira tsiku ndi tsiku kumafunikira kwa miyezi ingapo (mpaka kufunika kwa insulin kukhazikika).

Malangizo apadera ogwiritsira ntchito Protafan nm penfill.

Mosamala, mlingo wa mankhwalawa umasankhidwa mwa odwala omwe ali ndi vuto laubongo lomwe limakhalapo malinga ndi mtundu wa ischemic komanso mitundu yayikulu ya matenda a mtima a ischemic.
Kufunika kwa insulin kungasinthe mu milandu yotsatirayi: mukasinthana ndi mtundu wina wa insulin, mukamasintha zakudya, kutsegula m'mimba, kusanza, pakusintha kuchuluka kwa zochitika zolimbitsa thupi, matenda a impso, chiwindi, pituitary, chithokomiro cha chithokomiro.
Kusintha kwa mlingo wa insulin kumafunikira matenda opatsirana, matenda a chithokomiro, matenda a Addison, hypopituitarism, kulephera kwaimpso, komanso matenda osokoneza bongo omwe ali ndi zaka zopitilira 65.

Kusamutsa wodwala kupita ku insulin yaumunthu kuyenera kukhala kovomerezeka nthawi zonse ndikuchitika moyang'aniridwa ndi dokotala.

Zomwe zimayambitsa hypoglycemia zitha kukhala: insulin, mankhwala osokoneza bongo, kudumpha chakudya, kusanza, kutsegula m'mimba, kupsinjika kwa thupi, matenda omwe amachepetsa kufunikira kwa insulin (matenda a impso ndi chiwindi, komanso hypofunction ya adrenal cortex, pituitary kapena chithokomiro cha chithokomiro) (mwachitsanzo, khungu pamimba, phewa, ntchafu), komanso mogwirizana ndi mankhwala ena. Ndikotheka kuchepetsa kuchuluka kwa shuga m'magazi posamutsa wodwala kuchokera ku insulin ya nyama kupita ku insulin ya anthu.

Wodwalayo ayenera kudziwitsidwa za zomwe zimachitika mu vuto la hypoglycemic, za zizindikiro zoyambirira za kukomoka kwa matenda ashuga komanso kufunika kofotokozera dokotala za kusintha konse komwe ali.

Pankhani ya hypoglycemia, ngati wodwalayo akudziwa, adayikidwa dextrose mkati, s / c, iv kapena iv pakamwa jakisoni kapena iv hypertonic dextrose solution. Ndi chitupa cha hypoglycemic coma, 20-40 ml (mpaka 100 ml) wa 40% dextrose solution amawayamwa kudzera mu mtsempha kulowa kufikira wodwalayo atatuluka.

Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia mwa iwo podya shuga kapena zakudya zambiri zamagulu ochulukirapo (odwala amalimbikitsidwa kuti azikhala ndi shuga osachepera 20 g).

Kulekerera kwa mowa kwa odwala omwe amalandira insulin kumachepetsedwa.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Chizolowezi chokhala ndi hypoglycemia chimatha kuperewera kuthekera kwa odwala kuyendetsa magalimoto ndi kugwira ntchito ndi zida.