Maantibiotic agwira kalekale m'moyo wamunthu. Tsopano mutha kupeza mankhwala ochepetsa mphamvu ya antibacterial, sopo wa antibacterial, gel osakaniza kapena kupukuta, ndi zina zotero. Koma gwiritsani ntchito njira zonse mosamala. Makamaka pankhani ya mankhwala. Nkhani ya lero ikufotokozerani zomwe Gentamicin-Akos ndi. Pazomwe mafuta omwe amagwiritsidwa ntchito, ndipo pazinthu zina zimakhala bwino kukana, muphunziranso zambiri.

Pharmacokinetics

Mukatha kugwiritsa ntchito, malonda sakhala osakanikirana kunja. Mankhwalawa amathandizira msanga pamalo a kutupa kapena bala.

Pambuyo makonzedwe intramuscularly, yogwira mankhwala mofulumira odzipereka. Excretion ili ndi mkodzo ndi bile. Amamangiriza mapuloteni ena am'madzi a plasma.

Kuponyedwa kwa madontho amaso kumatha kudziwika kuti ndi kochepa.

Contraindication

Mafuta sayenera kulimbikitsidwa pochiritsa munthu ngati ali ndi chidwi chogwiritsa ntchito mankhwalawa (kuphatikizapo mbiri) kapena aminoglycosides, uremia, kuchepa kwa mitsempha ya mitsempha, kuwonongeka kwa aimpso.

Gentamicin Akos amagwiritsidwa ntchito pochiza zotupa za maso.

Mankhwala

Kumangiriza ku gawo la 30S la ribosomes ndikusokoneza kaphatikizidwe ka mapuloteni, kulepheretsa mapangidwe azovuta kuyendetsa ndi mthenga RNA, ndikuwerenga molakwika kwa code genetic ndikupanga mapuloteni osagwira ntchito. Pozama kwambiri, imaphwanya cholepheretsa ntchito ya nembanemba ya cytoplasmic ndikuyambitsa kufa kwa tizilombo.

Kugwiritsa ntchito polimbana ndi mabakiteriya ambiri opanda gramu komanso gramu. Wotengeka kwambiri ndi ma gramicin (MPC ochepera 4 mg / l) ma gram osasokoneza 4 - Proteus spp. (kuphatikiza mitundu ya indole-positive ndi indole-hasi), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., tizilombo tating'onoting'ono ta gram - Staphylococcus spp. (kuphatikiza ndi penicillin zosagwira), wovuta ndi MIC 4-8 mg / l - Serratia spp., Klebsiella spp., Pseudomonas spp. (kuphatikiza Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Resistant (MPC oposa 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Streptococcus spp. (kuphatikiza Streptococcus pneumoniae ndi ma group D), Bacteroides spp., Clostridium spp., Providencia rettgeri. Kuphatikiza ndi penicillins (kuphatikizapo benzylpenicillin, ampicillin, carbenicillin, oxacillin), wogwira kapangidwe kazenera ka cell wa tizilombo, imagwira ntchito motsutsana ndi Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus faiumium ndi pafupifupi onse a Streptococins awo mitundu (kuphatikizapo Streptococcus faecalis liguifaciens, Streptococcus faecalis zymogene), Streptococcus faecium, Streptococcus durans. Kukana kwa tizilombo tating'onoting'ono tating'onoting'ono kumayamba pang'onopang'ono, komabe, zovuta zosagwirizana ndi neomycin ndi kanamycin zimasonyezanso kukana kwa glamicin (osakwanira pazowonjezera). Zisakhudze anaerobes, bowa, ma virus, protozoa.

Bongo

Zizindikiro: yafupika ya kuchepa kwa mitsempha (kupuma pomanga).

Chithandizo: Mankhwala a anti-cholinesterase (Proserinum) ndi kukonzekera kwa calcium (5-10 ml yankho la 10% ya calcium chloride, 5-10 ml ya yankho la 10% ya calcium gluconate) amapezeka mwa akulu. Prozerin isanakhazikitsidwe, atropine muyezo wa 0.5-0.7 mg imayendetsedwa mwachangu iv, kuwonjezereka kwamkati ndikuyembekezeredwa, ndipo 1.5-2 mphindi pambuyo pake, 1.5 mg (3 ml ya yankho la 0.05%) ya Prozerin. Ngati mphamvu ya mankhwalawa inali yosakwanira, mlingo womwewo wa Prozerin umaperekedwanso (ndikuwoneka kwa bradycardia, jekeseni wowonjezera wa atropine amaperekedwa). Ana amapatsidwa mankhwala owonjezera calcium. Woopsa kukhumudwa kupuma, makina mpweya wabwino amafunikira. Itha kuthandizidwa ndi hemodialysis (yothandiza kwambiri) komanso peritoneal dialysis.