Malangizo ogwiritsira ntchito "Rosinsulin S", zikuonetsa, contraindication, mawonekedwe, mawonekedwe omasulidwa, mavuto

Njira yolowera insulin m'mbale

(yatsekedwa m'matumba ndi mabotolo a 5 ndi 10 ml)

Ngati wodwala agwiritsa mtundu umodzi wa insulini yokha:

1. Thirani mankhwala okhala ndi mphira.

2. Thirani mpweya mu syringe kuchuluka kogwirizana ndi insulin yomwe mukufuna. Ikani mpweya mu vial of insulin.

3. Tembenuza vial ndi syringe mozondoka ndikujambula gawo la insulini mu syringe. Chotsani singano mu vial ndikuchotsa mpweya ku syringe. Onani ngati mlingo wa insulin ulondola.

4. Lowani nthawi yomweyo.

Ngati wodwala ayenera kusakaniza mitundu iwiri ya insulin:

1. Tulutsani mankhwala amtundu wa mphira pambale.

2. Nthawi yomweyo musanayimbe, ikulirani botolo la insulin yayitali ("yamtambo") pakati pama manja anu mpaka insuliniyo ikhale yoyera komanso yamitambo.

3. Thirani mpweya mu syringe muyezo wofanana ndi mlingo wa insulin yamitambo. Lowetsani mpweya mu vidiyo ya insulin yamitambo ndikuchotsa singano mu vial.

4. Jambulani mpweya mu syringe mu chiwerengero chofanana ndi mlingo wa insulin yochepa ("mandala"). Lowetsani mpweya mu botolo la insulin yabwino. Tembenuzani botolo ndi syringe mozondoka ndikuyimba muyezo wa insulin "yoyenera". Tulutsani singano ndikuchotsa mpweya ku syringe. Chongani mlingo woyenera.

5. Ikani singano mu vial ndi insulin ya "mitambo" yambiri, tembenuzani vinolo ndi syringe pansi ndikuyimba insulini yomwe mukufuna. Chotsani mpweya mu syringe ndikuwonetsetsa ngati mulondola. Ikani mankhwala osakanikirana a insulin nthawi yomweyo.

6. Nthawi zonse lembani insulin mosiyanasiyana monga tafotokozera pamwambapa.

Njira Yogwiritsira Ntchito Cartridge Injection

(yotsekedwa mu phukusi ndi makatoni 3 ml)

Makatoni okhala ndi mankhwala a Rosinsulin R adapangidwa kuti agwiritsidwe ntchito ndi Autopen Classic 1-Unit, Autopen Classic 2-Unit syringe cholembera yopangidwa ndi Owen Mumford Ltd., United Kingdom kapena ROSINSULIN ComfortPen reusable syringe cholembera chopangidwa ndi LLC Chomera cha Medsintez, Russia.

Wodwalayo ayenera kuchenjezedwa za kufunika kotsatira malangizo mosamala mu malangizo ogwiritsira ntchito cholembera cha syringe popereka insulin.

Musanagwiritse ntchito, onetsetsani kuti palibe zowonongeka (mwachitsanzo, ming'alu) pa cartridge ndi Rosinsulin P. Osagwiritsa ntchito cartridge ngati pali zowonongeka. Kathumba katayikidwa mu cholembera, chingwe chautoto chiyenera kuwonekera kudzera pazenera la wonyamulira.

Pambuyo pa jekeseni, singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera. Sungani batani kuti lipanikizidwe mpaka singano itachotsedwa kwathunthu pakhungu, ndikuwonetsetsa kuti mayendedwe olondola a mankhwalawo komanso kuthekera kwa magazi kapena zamitsempha kulowa mu singano kapena katemera wa insulin ndizochepa.

Katemera ndi Rosinsulin P adapangidwira kuti azigwiritsa ntchito payekhapayekha ndipo sakukwaniritsidwa.

Ndi zala ziwiri, tengani khola, ikani singano m'munsi mwa khola pakona pafupifupi 45 ° ndikuvulaza insulin pansi pa khungu. Pambuyo pa jekeseni, singano imayenera kukhalabe pansi pakhungu kwa masekondi osachepera 6 kuti muwonetsetse kuti insulini idayikidwa kwathunthu. Ngati magazi abwera pamalo opukusira jakisoni atachotsa singano, pang'onopang'ono dinani jakisoniyo ndi swab wothira ndi yankho la mankhwala ophera tizilombo. Ndikofunikira kusintha tsamba la jakisoni.

Maupangiri akugwiritsira ntchito cholembera chazaza chokha cha Autopen Classic 1-Unit

Autopen Classic Syringe pen ndi cholembera chosavuta kugwiritsa ntchito njira imodzi yosiyanasiyana ya jakisoni yambiri, yopangidwira makina a insulin Rosinsulin ndi zochitika za 100 IU / ml mu ma cartridge atatu a 3.0 ml. Yogwirizana ndi singano iliyonse ya zolembera za syringe. Chonde onani malangizo oyambira pang'onopang'ono ogwiritsira ntchito zolembera.

Kulephera kutsatira malangizo kungachititse kuti mupeze Mlingo wa insulin yolondola.

Kuphatikizidwa kwa cholembera chodzaza ndi zotayira

3. Tulutsani batani

4. Mlingo Wosankha

6. Wogulitsa Cartridge

8. Kutulutsa batani chosinthira

9. Mlingo Wosankha Dose

Kukonzekera kuti mugwiritse ntchito

Kokani chipewa cha cholembera chodzaza ndi syringe kuti muchichotse. Osachotsa cholembera ku cholembera chodzaza ndi zotayira.

Chotsani filimu yoteteza ku singano yatsopano (singano yophatikizidwa). Konzani singano mwachindunji pa chosungira. Chotsani chophimba chakunja ndi kapu ya singano.

Tsatirani masitepe a 2-3 musanadwe jekeseni iliyonse. Ndikofunika kukonzekera cholembera chodzaza ndi zotayira kuti muchotsemo mpweya wonse womwe ungakhale mkati mwa singano. Musanagwiritse ntchito, ikani magawo 8 pa chosankha cha mankhwala (mkuyu. 2A / 2B).

Sungani cholembera chodzaza ndi singano. Press ndikusunga batani loyambira mpaka chithunzi cha muvi pa cholembera cholembera chibwereranso pamzere woyambira pa cholembera cha mankhwala.

Sonkhanitsani ndikuchepetsa ziwalo ziwiri chilichonse mpaka dontho la insulin lithe kumapeto kwa singano (mkuyu. 3A / 3B). Tsopano cholembera chodzaza ndi syringe chokha chatsala kuti chigwiritsike ntchito.

Ngati mukuchita gawo lachitatu, wosankhidwayo wa mankhwalawa sabwerera pamzere woyambira ndipo insulin siyikupezeka kumapeto kwa singano, ndiye kuti mwina singano yomwe imagwiritsidwa ntchito ya cholembera yodzazidwa isanathe. Poterepa, chotsani singano yakale ndikuisintha ndi yatsopano. Bwerezaninso masitepe a 2-3.

Onetsetsani kuti muvi ► pa thupi la syringe yomwe yadzazidwa kale mpaka mzere woyamba wa cholembera. Imbani manambala ofunikira amayunitsi. Osatembenuza wokonza mlingo panjira ina, zomwe zingayambitse kuwonongeka kwa cholembera chadzadzacho ndipo, chifukwa chake, mu gawo lolakwika la mankhwala.

Ngati mwangolipira kuchuluka kwa insulin yofunika kwambiri, tikulimbikitsani kuti muthetse muyeso yolakwika ndikudzazanso kuchuluka kofunikira.

Musanabaye jekeseni, onetsetsani kuti muvi wa ► ukuonetsa kuchuluka kwa mayunitsi pazomwe mungayankhe. Mwachitsanzo, Chithunzi 4A ndi 4B chikuwonetsa mawonekedwe olondola a insulin 20.

Ikani singano pogwiritsa ntchito jakisoni yemwe dokotala wanu wakupatsani.

Kanikizani batani lomasulira kuti mulowe ndi singano ndikuyika mpaka mzere woyamba wa cholembera wosankha ubwereranso ku cholembera ► pa thupi la syringe yomwe idadzazidwa. Werengani mpaka 10 ndikutulutsa singano kuchokera pakhungu lanu.

Ngati kusankha kosankhidwa kwa mankhwalawo kuyimitsidwa mzere woyamba usanayanjane ndi muvi wa ►, zikutanthauza kuti simunalandire mlingo wa insulin. Dongosolo chosankha chikuwonetsa kuchuluka kwa magawo omwe amayenera kuperekedwa kwa insulin yonse.

Chotsani singano yakunja ndikuchotsa singano kuchokera ku syringe yomwe yadzaza kale. Nthawi zonse onetsetsani kuti singanoyo yasokonekera. Ikani kapu ya cholembera chodzaza ndi syringe m'malo ake (mkuyu. 6). Kutaya singano zogwiritsidwa ntchito kuyenera kuchitika molingana ndi malingaliro a ogwira ntchito yazaumoyo komanso zaukhondo komanso zodwala.

· Cholembera chodzaza chisanadze chitha kugwiritsidwa ntchito mukakambirana ndi othandizira azaumoyo.

Musanapange jekeseni iliyonse, onetsetsani kuti cholembera chodzaza ndi cholembera chili ndi mtundu woyenera wa insulini womwe amapereka kwa omwe amakuthandizani pazaumoyo.

· Werengani ndikutsatira malangizo a mankhwalawa. Nthawi zonse onetsetsani kuti cholembera chadzaza chomwe sichinadzazidwe nchakonzedwa kuti chigwiritsidwe ntchito molingana ndi buku ndi ndima 2-3.

Kuphwanya njira pokonzekera cholembera chodzaza chimbudzi kuti mugwiritse ntchito kungayambitse kuti mupeze insulin yolondola.

Pakani jakisoni aliyense, gwiritsani ntchito singano yatsopano. Jakisoni itangotha, singano imayenera kuchotsedwa ndikuitaya mosamala. Ngati singano ikatsalabe pa cholembera, izi zimatha kubweretsa kutsukidwa ndikusokoneza kulondola kwa mlingo.

Ngati mutachotsa singano ku cholembera, mutha kupeza inshuwaransi, mwina simunakhale ndi insulin yonse. Osayesa kudzipangira mlingo wa insulin womwe watayika ndi jakisoni wachiwiri (muyika chiopsezo chochepetsa kwambiri magazi anu). Monga kusamala, tikukulangizani kuti mupange shuga lanu la magazi pafupipafupi, werengani malangizo ogwiritsira ntchito insulin, kapena peanani ndi katswiri wazachipatala.

· Funsani dokotala ngati mupeza shuga wambiri.

Kusunga ndi kutaya

· Chingwe chodzaza ndi syringe cholembera chizisungidwa nthawi zonse ndi singano kuchotsedwa ndi chipewa.

· Cholembera chodzaza ndi zotayira sichitha kugwiritsidwa ntchito ngati chakhala kunja kwa firiji kwa nthawi yopitilira nthawi yodziwika mu malangizo ogwiritsira ntchito mankhwala.

· Cholembera chimbudzi chomwe simuchigwiritsa ntchito chomwe mukugwiritsa ntchito pano chiyenera kusungidwa kutentha 15-25 ° C osaposa masiku 28, otetezedwa ku dzuwa ndi kutentha mwachindunji.

Lambulani cholembera ndi nsalu yonyowa. Osamiza cholembera m'madzi.

· Zola zomwe zisagwiridwe ntchito zomwe sizigwiritsidwa ntchito ziyenera kusungidwa mufiriji kutentha kwa 2 mpaka 8 ° C.

· Sungani zotayira zanthawi zonse kuchokera kwa ana.

· Tayetsani masingano omwe agwiritsidwa ntchito m'makina awo olemba, kapena malinga ndi zomwe akatswiri azaumoyo akuthandizani.

Chotsani ma cholembera ogwiritsira ntchito syringe popanda singano zophatikizidwa kwa iwo komanso mogwirizana ndi upangiri wa dokotala.

Cholembera cha syopinge ya Autopen Classic chidayesedwa bwino ndipo chimakwaniritsa zofunikira za ISO 11608-1 kuti mudziwe kulondola kwa mlingo.

Bukuli limaphatikizidwa ndikuyika ndi zolembera za 3 ml zitha kutayika.

Wopanga cholembera: "Owen Mumford Ltd.", UK.

Maupangiri akugwiritsira ntchito cholembera chodzaza ndi ROSINSULIN ComfortPen chopangidwa ndi LLC Plant Medsintez

Cholembera cha syringe chidapangidwa kuti chithandizire Rosinsulin insulin ndi zochitika za 100 IU / ml mu ma cartridge a 3.0 ml. Yogwirizana ndi singano iliyonse ya zolembera za syringe.

Chonde onani malangizo oyambira pang'onopang'ono ogwiritsira ntchito zolembera.

Kulephera kutsatira malangizo kungachititse kuti mupeze Mlingo wa insulin yolondola.

Kuphatikizidwa kwa cholembera chodzaza ndi zotayira ROSINSULIN ComfortPen chopangidwa ndi Plant Medsintez LLC

1. Kukonzekera kugwiritsa ntchito

A. Kokani chipewa cha cholembera chodzaza ndi zotayira kuti muchotse. Osachotsa cholembera ku cholembera chodzaza ndi zotayira.

B. Chotsani filimu yoteteza ku singano yatsopano (singano yophatikizidwa).

Mkuyu. 2. Magawo a singano

Konzani singano mwachindunji pa chosungira.

Chotsani zakunja, ndiye zingano zamkati za singano. Osataya kapu yakunja.

B. Ndikofunikira kukonza cholembera chodzaza chisanachitike musanagwiritse ntchito koyamba kuti muchotse mpweya wonse womwe ungakhale mkati mwa katiriji ndi singano.

Khazikitsani magawo 8 pa chosankha cha mankhwala.

Sungani cholembera chodzaza ndi singano. Kanikizani batani lomasulira ndi kupitiriza kulikakanikiza mpaka zero zero mu cholembera chosankha cha machesi ikugwirizana ndi cholembera pa cholembera cholembera. Ngati insulin pambuyo pake sichikuwoneka kumapeto kwa singano, ndiye kuti tsatirani gawo 1G.

D. Sungani ndikuchepetsa ziwalo ziwiri chilichonse mpaka insulin ikawonekera kumapeto kwa singano (mkuyu. 5, 6).

Tsopano cholembera chodzaza ndi syringe chokha chatsala kuti chigwiritsike ntchito.

Ngati cholembera chosankha sichibwerera ku zero ndipo insulini siyikupezeka kumapeto kwa singano, ndiye kuti zotheka kuti singano yomwe imagwiritsidwa ntchito ya cholembera yodzaza ndi syringe siyingatheke. Poterepa, chotsani singano yakale ndikuisintha ndi yatsopano. Kenako bwerezani gawo 1G.

2. Dose management

A. Onetsetsani kuti cholembera pa cholembera chodzaza ndi zotayira chimaloza kumaso kwa ziro mu zenera la chosankha. Imbani manambala ofunikira amayunitsi.

Mlingo wolakwika wa insulin mu cholembera cha ROSINSULIN Comfort cholembera chopangidwa ndi Zavod Medsintez LLC chitha kusinthidwa ndikutembenukira kwa chosankha cha mtundu uliwonse.

Pamaso jakisoni, onetsetsani kuti cholembera pa thupi chimaloza nambala yofunikira ya mawunidwe muwindo la chosankha cha mlingo.

B. Ikani singano pogwiritsa ntchito jakisoni yemwe dokotala wanu wakupatsani.

Kanikizani batani lomasulira ndi kupitiriza kulikakanikiza mpaka zero zero mu cholembera chosankha cha machesi ikugwirizana ndi cholembera pa cholembera cholembera. Werengani mpaka 10 ndikutulutsa singano kuchokera pakhungu lanu.

Mukamayambitsa mankhwalawa, gwiritsani ntchito kukanikizira batani kuti mutulutse dzanja ndi chala chamanja mosatalikirana ndi cholowera kutalika kwa syringe, osakhudza gawo lozungulira la cholembera, kuphatikizapo chosankhira mlingo.

Ngati chosankha cha dokotalayo chitayima chizindikiro cha zero chisanalumikizane ndi chojambulira, zikutanthauza kuti simunalandire mlingo wa insulin. Pankhaniyi, chosankha cha mankhwalawa chikuwonetsa kuchuluka kwa mayunitsi omwe ayenera kulowetsedwa insulin isanayambike.

3. Kuchotsa singano

Ikani chotsekera chakunja pa singano ndikumasulira singano kuchokera ku cholembera chodzaza.

Nthawi zonse onetsetsani kuti singanoyo yasokonekera. Sinthani kapu ya syringe yomwe yadzazidwa kale. Kutaya singano zogwiritsidwa ntchito kuyenera kuchitika molingana ndi malingaliro a ogwira ntchito yazaumoyo komanso zaukhondo komanso zodwala.

Nthawi iliyonse singano ikasinthidwa, tsatirani masitepe 1B ndi 1D.

· Cholembera chodzaza chisanadze chitha kugwiritsidwa ntchito mukakambirana ndi othandizira azaumoyo.

Popewa matenda, cholembera chodzaza, chokhachokha chokha chizigwiritsa ntchito wodwala m'modzi ndipo sayenera kupita kwa wina.

· Ngati mukuipitsidwa ndi zinyalala za mphira, ndikuthira mankhwala ndi ma antiseptic, dikirani mpaka diskiyo itayimikiratu isanakhazikitse singano.

· Ngati mukukayikira kuti cholembera chida chodzaza ndi syringe chawonongeka, gwiritsani ntchito cholembera chatsopano chodzaza.

Musanapange jekeseni iliyonse, onetsetsani kuti cholembera chodzaza ndi cholembera chili ndi mtundu woyenera wa insulini womwe amapereka kwa omwe amakuthandizani pazaumoyo.

· Werengani ndikutsatira malangizo a mankhwalawa. Nthawi zonse onetsetsani kuti cholembera chomwe sichinadzazidwepo ndi choti chitha kukonzedwa kuti chigwiritsidwe ntchito molingana ndi bukuli. Kuphwanya njira pokonzekera cholembera chodzaza chimbudzi kuti mugwiritse ntchito kungayambitse kuti mupeze insulin yolondola.

Pakani jakisoni aliyense, gwiritsani ntchito singano yatsopano. Atangobayira jekeseni, singano imayenera kuchotsedwa ndikuitaya mosamala. Ngati singano ikatsalabe pa cholembera, izi zimatha kubweretsa kutsukidwa ndikusokoneza kulondola kwa mlingo.

Ngati mutachotsa singano ku cholembera, mutha kupeza inshuwaransi, mwina simunakhale ndi insulin yonse. Osayesa kudzipangira mlingo wa insulin womwe watayika ndi jakisoni wachiwiri (muyika chiopsezo chochepetsa kwambiri magazi anu). Monga kusamala, tikukulangizani kuti mupange shuga lanu la magazi pafupipafupi, werengani malangizo ogwiritsira ntchito insulin, kapena pezani akatswiri azaumoyo.

· Funsani dokotala ngati mupeza shuga wambiri.

Kusunga ndi kutaya

· Chingwe chodzaza ndi syringe cholembera chizisungidwa nthawi zonse ndi singano kuchotsedwa ndi chipewa.

· Cholembera chodzaza ndi zotayira sichitha kugwiritsidwa ntchito ngati chakhala kunja kwa firiji kwa nthawi yopitilira nthawi yodziwika mu malangizo ogwiritsira ntchito mankhwala.

· Cholembera chimbudzi chomwe simuchigwiritsa ntchito chomwe mukugwiritsa ntchito pano chiyenera kusungidwa kutentha 15-25 ° C osaposa masiku 28, otetezedwa ku dzuwa ndi kutentha mwachindunji.

Lambulani cholembera ndi nsalu yonyowa. Osamiza cholembera m'madzi.

· Zola zomwe zisagwiridwe ntchito zomwe sizigwiritsidwa ntchito ziyenera kusungidwa mufiriji kutentha kwa 2 mpaka 8 ° C.

· Sungani zotayira zanthawi zonse kuchokera kwa ana.

· Tayetsani masingano omwe agwiritsidwa ntchito m'makina awo olemba, kapena malinga ndi zomwe akatswiri azaumoyo akuthandizani.

Ma cholembera opanda kanthu sayenera kugwiritsidwanso ntchito. Taya zolembera zomwe mugwiritse ntchito singano popanda singano zophatikizidwa kwa iwo komanso mogwirizana ndi malingaliro a dokotala.

Bukuli limaphatikizidwa ndikuyika ndi zolembera za 3 ml zitha kutayika.

Wopanga cholembera wa Syringe: Medsintez Plant LLC, Russia.

Mankhwala

Mankhwala Rosinsulin P - insulin yaumunthu yomwe imapezedwa ndi kuyambiranso biotechnology ya DNA pogwiritsa ntchito kupsyinjika E. coli. Ndikukonzekera mwachidule insulin. Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsanso njira zina, kuphatikizapo kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthase, etc.). Kutsika kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe ka intracellular, kuchuluka kwa minofu, kukondoweza kwa lipogenesis, glycogenogeneis, kuchepa kwa kuchuluka kwa shuga ndi chiwindi, etc.

Kutalika kwa zochita za insulin kukonzekera kumatsimikiziridwa makamaka ndi kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo, njira ndi malo oyendetsera, makulidwe a subcutaneous mafuta wosanjikiza, monga matenda a shuga), chifukwa chake zochitika za insulin zimasinthasintha kwambiri, monga anthu osiyanasiyana, ndi munthu yemweyo.

Mbiri yakuchitapo kanthu kwa jakisoni wocheperachepera (ziwerengero): kuyambika kwa mphindi 30, kuchuluka kwake kumakhala pakati pa maola 2 ndi 4, nthawi yayitali ndi maola 6-8.

Pharmacokinetics

Hafu ya moyo wa insulini kuchokera m'magazi ndi mphindi zochepa chabe.

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo wa insulin, njira ndi malo oyendetsera, makulidwe a subcutaneous mafuta wosanjikiza ndi mtundu wa matenda osokoneza bongo). Chifukwa chake, magawo a pharmacokinetic a insulin ali ndi kusinthasintha kwakukulu kwapakati pa intaneti ndi munthu payekha.

Kuzindikira kwakukulu (C_max) plulin ya insulin imatheka mkati mwa maola 1.5-2,5 pambuyo povomerezeka.

Palibe zomangamanga zomanga mapuloteni a plasma zimadziwika, kupatulapo ma antibodies ozungulira a insulin (ngati alipo).

Insulin yaumunthu imapangidwa ndi ma insulinase kapena ma enzyme osokoneza bongo a insulin, komanso mwina ndi protein disulfide isomerase.

Amaganiziridwa kuti mu molekyulu ya insulin ya anthu pali malo angapo a cleavage (hydrolysis), komabe, palibe amodzi a metabolites omwe amapangidwa chifukwa cha cleavage akugwira ntchito.

Hafu ya moyo (T_1/2) chimadziwika ndi kuchuluka kwa mayamwidwe subcutaneous minofu. Chifukwa chake, T_1/2 m'malo mwake, ndi gawo la mayamwidwe, ndipo osati makamaka muyeso wochotsa insulini kuchokera ku plasma (T_1/2 insulin yochokera m'magazi ndi mphindi zochepa chabe).

Kafukufuku wasonyeza kuti T_1/2 ili pafupifupi 2-5 maola.

Ana ndi achinyamata

Mbiri ya pharmacokinetic ya mankhwala a Rosinsulin P mwa ana ndi achinyamata ndi chimodzimodzi ndi akulu. Komabe, pali kusiyana pakati pa magulu amisinkhu yosiyanasiyana malinga ndi chizindikiro monga C_max, yomwe ikugogomezeranso kufunika kwa kusankha kwa munthu payekha.

• Matenda a shuga.
• Zinthu zadzidzidzi kwa odwala matenda a shuga, komanso limodzi ndi kuwonongeka kwa kagayidwe kazakudya.

Mimba komanso kuyamwa

Palibe choletsa kuchiza matenda osokoneza bongo a shuga ndi insulin pa nthawi yomwe ali ndi pakati, popeza insulin siyidutsa chotchinga. Mukakonzekera kukhala ndi pakati komanso panthawi imeneyi, ndikofunikira kulimbikitsa chithandizo cha matenda ashuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri. Pambuyo pobadwa, kufunikira kwa insulin kumabwereranso msanga momwe kunaliri asanakhale ndi pakati. Palibe choletsa pa chithandizo cha matenda osokoneza bongo a shuga ndi insulin panthawi yoyamwitsa, popeza chithandizo cha mayi ndi insulin ndi chabwino kwa mwana. Komabe, kusintha kwa insulin ndi / kapena zakudya kungakhale kofunikira, chifukwa chake kuyang'anira mosamala ndikofunikira kuti bata likhale ndi insulin.

Mlingo ndi makonzedwe

Mankhwala Rosinsulin P adapangidwira kuti azigwiritsa ntchito, kumitsempha, mtsempha wamitsempha. Mlingo ndi njira makonzedwe a mankhwala mtima ndi dokotala aliyense payekha malinga ndi kuchuluka kwa shuga m'magazi. Pafupifupi, tsiku lililonse mlingo wa mankhwalawo umachokera ku 0,3 IU / kg mpaka 1 IU / kg kulemera kwa thupi (kutengera umunthu wa wodwalayo komanso kuchuluka kwa shuga m'magazi). Kufunika kwa insulin tsiku lililonse kumatha kukhala kwabwino kwambiri kwa odwala omwe ali ndi insulin kukaniza (mwachitsanzo, nthawi yakutha msinkhu, komanso odwala omwe ali ndi kunenepa kwambiri), komanso kutsika mwa odwala omwe ali ndi zotsalira za insulin.

Mankhwalawa umaperekedwa kwa mphindi 30 asanadye kapena chakudya. Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.

Ndi monotherapy ndi mankhwala, pafupipafupi makonzedwe ndi 3 pa tsiku (ngati ndi kotheka, 5-6 pa tsiku). Pa mlingo wa tsiku ndi tsiku wopitilira 0.6 IU / kg, ndikofunikira kulowa mu mawonekedwe a jekeseni a 2 kapena kuposa m'malo osiyanasiyana a thupi.

Mankhwala Rosinsulin P nthawi zambiri amathandizidwa mosachepera zigawo za khoma lachiberekero lakumbuyo. Jekeseni amathanso kuchitika m'tchafu, matako kapena dera lonyowa la phewa. Ndi kuyambitsa kwa mankhwala m'dera lakhomopo la khomo lachiberekero, kuyamwa mwachangu kumatheka bwino kuposa kumayambitsa madera ena. Ndikofunikira nthawi zonse kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Intramuscularly, mankhwala a Rosinsulin P amatha kuperekedwa kokha ngati akuwongoleredwa ndi dokotala. Mitsempha yoyeserera ya mankhwala ikhoza kuchitika kokha ndi akatswiri azachipatala.

Rosinsulin R ndi insulin yochepa ndipo amagwiritsidwa ntchito limodzi ndi insulin (Rosinsulin C).

Mukamagwiritsira ntchito zolembera zama syringe zosadzaza kale, muyenera kuchotsa cholembera mufiriji musanagwiritse ntchito ndikulola kuti mankhwalawo afikire kutentha kwa chipinda. Mankhwala a Rosinsulin P mu cholembera chimbale sangathe kugwiritsa ntchito ngati atapanga mazira. Ndikofunikira kuti mutsatire malangizo ogwiritsira ntchito cholembera chomwe amaperekedwa ndi mankhwalawo.

Matenda okhala ndi vuto limodzi, makamaka opatsirana komanso kutentha thupi, nthawi zambiri amalimbikitsa kufunika kwa insulin. Kusintha kwa magazi kungafunikenso ngati wodwala ali ndi matenda a impso, chiwindi, mkhutu wa adrenal ntchito, pituitary gland kapena chithokomiro cha chithokomiro.

Kufunika kosinthidwa kwa mlingo kumatha kuonekanso posintha zolimbitsa thupi kapena zakudya zomwe wodwala amadya. Kusintha kwa Mlingo kungafunike posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina.

Zotsatira zoyipa

Zotsatira zoyipa kwambiri za insulin ndi hypoglycemia. Pa maphunziro azachipatala, komanso munthawi yogwiritsira ntchito mankhwalawa atamasulidwa pamsika waogula, zidapezeka kuti zochitika za hypoglycemia zimasiyanasiyana malinga ndi kuchuluka kwa odwala, kuchuluka kwa mankhwalawa, komanso kayendedwe ka glycemic (onani. "Kufotokozera kwamomwe munthu amakumana ndi zovuta").

Pa gawo loyambirira la insulin, zolakwika zotupa, zotumphukira ndi zomwe zimachitika pamalo opangira jakisoni (kuphatikizapo kupweteka, redness, urticaria, kutupa, hematoma, kutupa ndi kuyunkhira pamalo a jekeseni. Zizindikirozi nthawi zambiri zimakhala zakanthawi. Kusintha kwapang'onopang'ono pakuwongolera glycemic kumatha kubweretsa mkhalidwe wa "ululu wammbuyo wamitsempha," womwe umatha kusintha. Kulimbitsa kwa insulin mankhwala ndikusintha kolimba kwa mphamvu ya kagayidwe kazakudya kungayambitse kuwonongeka kwakanthawi mu matenda a shuga, pomwe kusintha kwakanthawi kwakanthawi ka glycemic kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy.

Mndandanda wazotsatira zoyipa zimaperekedwa pagome.

Zotsatira zonse zoyipa zomwe zaperekedwa pansipa, kutengera za mayeso azachipatala, zimayikidwa m'magulu molingana ndi kukula kwa chitukuko malinga ndi MedDRA ndi kachitidwe ka ziwalo. Zotsatira zoyipa zimafotokozedwa ngati: pafupipafupi (≥ 1/10), nthawi zambiri (≥ 1/100 to

Kutulutsa Fomu

Rosinsulin S imagulitsidwa ngati yankho lomveka bwino (mabotolo, makatoni olemba, zolembera zodzaza). Zowonjezera zimapezekanso m'maiko ena. Koma izi sizachidziwikire.

Mankhwalawa ayenera kusungidwa mufiriji kutentha kwa 2 mpaka 8 ° C. Mulimonse momwe mankhwalawo angagwiritsire ntchito popukutira. Pambuyo kutsegula, mankhwalawa amatha kusungidwa kutentha kwa firiji kwakanthawi - nthawi zambiri mwezi umodzi. Mankhwalawa sayenera kuwonekera padzuwa.

Ma insulin adapangidwa mu 1920s. Zidayamba kutulutsidwa kuchokera kuzinyama zanyama (nkhumba ndi ng'ombe). Masiku ano amapangidwa makamaka ndi njira zamaumboni. Insulin yothandizanso yakhala ikupezeka kuyambira 1980s.

Zizindikiro ndi contraindication

Insulin imagwiritsidwa ntchito pamitundu yonse ya matenda ashuga. Cholinga cha mankhwalawa ndi kuchepetsa matenda a glycemia, omwe angalepheretse zovuta za matenda ashuga. Mavutowa ndi monga kugunda kwa mtima ndi sitiroko, komanso khungu, kudula miyendo, komanso kulephera kwa impso. Amachitika chifukwa cha matenda obwera chifukwa cha matenda ashuga komanso kuwonongeka kwa mitsempha.

Ntchito mankhwalawa matenda a matenda ashuga, insulin nthawi ina idapezeka kuchokera ku nyama. Masiku ano, insulin ya nkhumba imagwiritsidwa ntchito mu mankhwala ochepa. Mafuta a insulin omwe amagwiritsidwa ntchito kwambiri. Natural endo native insulin sichimatha kuposa mphindi 6-7.

Pochiza matenda a shuga, ma insulin omwe amakhala osakhalitsa (omwe amatchedwa kuti insulin yakale kapena yakale) amagwiritsidwa ntchito. Komabe, kuchitapo kanthu kwakutali kumalimbikitsidwa kuti odwala ateteze ku hyperglycemia yambiri. Izi zinapangitsa kuti pakhale zinthu zomwe zimatchedwa kuti zazitali.

Mu Rosinsulin C, insulin imamangidwa ndi mapuloteni otchedwa protamine. Kutengera ngati mankhwala awa ali munjira yamakristali kapena ma block (amorphous), nthawi yawo yamachitidwe imasiyanasiyana. Mawonekedwe amorphous amawumbidwa ndi thupi mwachangu ndipo, motero, amakhalanso ofupikirako. Kukonzekera konse kwa insulini kumatulutsidwa pang'onopang'ono kwambiri kulowa mkati mwa jakisoni. Mu Rosinsulin, zotsatira zimangoyambira mphindi 90 jekeseni. Kuchuluka kwake kumatheka pambuyo pa maola 4-12, ndipo nthawi yake imatha kufika maola 24.

Mtundu wa mayankho onse omwe angathe kubayidwa ndikuti ma insulini amakhazikika mu mawonekedwe a makhiristo kapena zidutswa pansi pa wokwanira. Chifukwa chake, ndikofunikira kusakaniza madzimadzi bwinobwino musanabaye jekeseni wa subcutaneous.

"Rosinsulin C" imapangidwa chifukwa cha hypersensitivity, hypoglycemia ndi insulinoma. Zidziwitso zokwanira pazamankhwala osamala komanso magwiridwe antchito zimapezeka pazidziwitso zamankhwala. Mankhwala ambiri amakhudza shuga wanu wamagazi.

Mlingo ndi bongo

Malinga ndi malangizo ogwiritsira ntchito, mlingo womwe umayenera kuperekedwa umatsimikiziridwa payekhapayekha. Zimatengera zinthu zosiyanasiyana (mwachitsanzo, kunenepa kwambiri, zolimbitsa thupi, monga chakudya, matenda, kupsinjika). Mtengo wa shuga wamagazi uyenera kuyesedwa tsiku ndi tsiku.

Chifukwa cha kukomoka mkamwa bioavailability, insulin nthawi zambiri imayendetsedwa mwachisawawa, mwachitsanzo pamimba, ntchafu kapena matako. Odwala sayenera kuperekedwa kudzera muzibongo. Malo opangira punction ndi singano yovundikira ziyenera kusinthidwa ndi jakisoni aliyense.

Nthawi ya makonzedwe zimatengera mawonekedwe ndi yogwira pophika. Amathandizidwa ndi zolembera za insulin, mapampu, komanso ocheperako ndi ma syringe kuchokera ku mbale. Mitundu ina ya mankhwalawa ikhoza kupakidwa ndi wodwala.

Kuchita

Mankhwala osavomerezeka kuti aperekedwe limodzi ndi Mao inhibitors, beta-adrenergic receptors, fibrate, opioid analgesics, salicylic acid ndi maantibayotiki. Mankhwala a Glucocorticoid, mahomoni, diuretics, mahomoni okula, estrogens, salbutamol, clozapine angayambitse hyperglycemia ndipo, motero, amachepetsa mphamvu ya mankhwalawa. Musanagwiritse ntchito chilichonse, ndikofunikira kuti mupemphe katswiri woyenera.

"Rosinsulin S" - ma fanizo ndi cholowa m'malo mwa mankhwalawa:

Maganizo a odwala matenda ashuga komanso dokotala.

Rosinsulin S ndi mankhwala okwera mtengo koma ogwira mtima omwe ndakhala ndikugwiritsa ntchito kwa chaka chathunthu kuchiza matenda ashuga. Mankhwalawa amagwira ntchito kwanthawi yayitali, koma nthawi zina amayambitsa hypoglycemia. Sindikudziwa zoyipa zina kunyumba.

"Rosinsulin C" imagwira ntchito kwanthawi yayitali, motero, imatha kukulitsa chiopsezo cha hypoglycemia mu odwala matenda a shuga omwe amadalira insulin. Mankhwala tikulimbikitsidwa kuti atengedwe mosamalitsa pambuyo pokambirana ndi dokotala. Ndikofunikira kuyesa mitundu yonse ya ngozi ndi phindu la mankhwalawo.

Leonid Aleksandrovich, katswiri wa matenda ashuga

Mtengo (mu Russian Federation)

Mtengo wapakati pamsika wa mankhwalawo ndi 926 ma ruble aku Russia. Mtengo womaliza umalimbikitsidwa kuti ukayang'ane ndi wogulitsa zamankhwala, chifukwa amatha kusiyanasiyana.

Zofunika! Mankhwala amafesedwa mosamalitsa ndi mankhwala osungirako mankhwala. Popanda lingaliro, ndizoletsedwa kugwiritsa ntchito mankhwalawa.