Ciprofibrate: malangizo, ntchito, mtengo, ndemanga, kugwiritsa ntchito mankhwala

Mwa mitundu yosiyanasiyana ya mankhwala omwe amachepetsa cholesterol m'thupi, Ciprofibrate imadzipatula. Ili ndi lipid-kutsitsa kwenikweni, yomwe imakhala ndikukopa ma triglycerides, komanso ma lipoproteins apamwamba komanso otsika. Mankhwala ndi mankhwala kuti amaganiza kukula mtima. Kugwiritsa ntchito nthawi yayitali, kumalimbikitsa kulumikizidwa kwa fibrin ndi kutha kwa tendon xanthomas.

Malangizo ogwiritsira ntchito

Ciprofibrate imachepetsa cholesterol ndikusokoneza mapangidwe a mevalonic acid, omwe ndi chinthu chapakatikati chokhazikitsidwa ndikupanga ma steroids. Kumwedwa kwathunthu kwa mankhwalawa m'mimba ndi pakatha maola awiri mutamwa mapiritsi.

Zimachepetsa nawonso kuchuluka kwa ma triglycerides, kuletsa kaphatikizidwe ka cholesterol m'chiwindi ndikuwonjezera kupasuka kwake. Kuchotsa mthupi kumachitika osasinthika, ndi mkodzo.

Zizindikiro zazikulu za kumwa mankhwalawa ndi izi:

• hypertriglyceridemia, momwe kusintha kwa zakudya sikogwira ntchito mokwanira,
• kukhalapo kwa zinthu zoika pachiwopsezo (kukhala moyo wongokhala, kusuta fodya, chikhalidwe cholowa, matenda oopsa, etc.),
• endo native hypercholesterolemia.

Malinga ndi malangizo ogwiritsira ntchito, mlingo wa tsiku lililonse wa mankhwalawa ndi 100-200 mg. Kuchuluka kwa zolandilira patsiku ndi nthawi 1. Ngati wodwala ali ndi hypoalbuminemia, mlingo umachepetsedwa. Ndi pathologies a chiwindi kapena impso zoyambira mawonekedwe, tsiku ndi tsiku Mlingo umapezeka payekhapayekha.

Kuchita bwino kwambiri kwa chithandizo ndi Ciprofibrate kumawonedwa mukaphatikizidwa ndi zakudya za hypolipidemic komanso njira zina zochiritsira zosagwirizana ndi mankhwala.

Ndi chitukuko cha ziwengo, muyenera kukana kumwa mankhwalawo. Zizindikiro za tsankho zimaphatikizira zotupa pakhungu, kutupa kwa kupuma thirakiti, kuyabwa kwa khungu ndi khungu.

Contraindication

Nthawi zina, kutenga Ciprofibrate kumakhala koyipa. Chifukwa chake, ndikofunikira kuwerenga tanthauzo la mankhwalawo musanagwiritse ntchito.

Ndi zoletsedwa kumwa mankhwala motere:

• kulephera kwa chiwindi
• zaka za ana
• kusalolera payekhapayekha,
• kuwonongeka kwaimpso,
• mkaka ndi mkamwa.

Odwala omwe ali ndi vuto la chithokomiro, kusinthika kwachiwiri kwa mapangidwe amafuta kumawonedwa ndikugwiritsa ntchito mankhwalawa. Ndikofunikira kusintha msinkhu wawo musanagwiritse ntchito mankhwala.

Nthawi ya hypothyroidism, ma neuromuscular pathologies amapita patsogolo, limodzi ndi kuwonongeka kwa minofu yoyamba, komwe kumapangitsa kuti chiwopsezo cha mafupa awononge thupi.

Zotsatira zoyipa

Mukamatenga Ciprofibrate, zosintha zimawonedwa kuchokera ku magawo a labotale. Choyamba, izi zimawonekera pakuwonjezeka kwa LDH, CPK komanso kuwonjezeka kwapang'onopang'ono kwa zochitika za hepatic transaminases mu plasma.

Zotsatira zina zoyipa ndizophatikiza:

• zotupa pakhungu
• nseru
• kuchuluka kwa cholelithiasis,
• kupweteka kwam'mimba
• kuphwanya chopondapo.

Zofunika! Ndi kuwoneka kugona kwambiri ndi chizungulire, pali kuthekera kwoletsedwa kwakanthawi kantchito ya psychophysical

Kuchita ndi mankhwala ena

Mankhwala ena amatha kukulitsa mphamvu ya ciprofibrate, ena amasokoneza kuyamwa kwake. Pa chithandizo, mwayi wophatikiza mankhwala umakambidwa ndi dokotala payekhapayekha.

Pankhaniyi, mfundo zotsatirazi zimawerengedwa:

1. Kugwiritsa ntchito koprofibrate ndi anticoagulants osagwirizana kumatha kukhudza magazi. Chifukwa chake, mulingo woyenera wa Ciprofibrate umachepetsedwa katatu.
2. Nicotinic acid ndi mankhwala okhala ndi zomwe zili mkati mwake zimapangitsa lipid-kutsitsa mphamvu ya mankhwalawo poletsa kuyamwa kwa ma bile acid m'matumbo.
3. Ndi makonzedwe amakono a Ciprofibrate ndi Ibuprofen, kulephera kwaimpso kumayamba ndipo chiwopsezo chokhala ndi rhabdomyolysis chikuwonjezeka.
4. Kugwiritsa ntchito mankhwalawa ndi mankhwala ena ochokera m'gulu la fibrate ndizoletsedwa.
5. Kuphatikizidwa kwa mankhwalawa ndi mao inhibitors a MAO kumawonjezera chiopsezo cha hepatotoxicity.

Malangizo apadera

Kuchepa kwa ndende ya serum lipid kuyenera kuchitika pakatha miyezi 3-6 kuyambira poyambira chithandizo. Kusowa kwa mphamvu zabwino kumawonetsa kufunikira kwa othandizira ena.

Munthawi ya achire othandizira, ndikofunikira kuyang'ana ntchito yama transaminases miyezi iwiri iliyonse ndikupita mayeso oyenera. Izi ndichifukwa choti mwa odwala ena kuwonjezeka kwakanthawi kumawonedwa.

Ciprofibrate imatha kuthamangitsa zinthu zina kuchokera pamapuloteni chifukwa cha mphamvu yomanga mapuloteni a plasma.

Mulingo wovuta wa ntchito ya serum ALT ndi magawo zana. Kuchulukitsa chizindikiro ichi kukusonyeza kufunikira kwa kusiya ntchito kwamankhwala.

Kodi ma fiber ndi momwe amachitira

Muzipatala ndi ma profid apamwamba a lipid, mankhwala a magulu otsatirawa amapezeka nthawi zambiri - fibrate ndi ma statins. Nkhaniyi imatsatila gulu loyamba.

Fibates ndi mankhwala omwe amapangidwa kuchokera ku fibroic acid.

Makina a zochita za fibrate ndikupondera kupanga ma lipoproteins otsika kwambiri otsika kwambiri m'chiwindi. Kuphatikiza apo, michere imathandizira kuchotsedwa kwa cholesterol yoyipa m'thupi. Mothandizidwa ndi mankhwalawa:

• kuchuluka kwa zotengera kumayenda bwino,
• Kuchulukana kwa khoma lamankhwala kumakulirakulira,
• Zizindikiro za cholesterol yayikulu m'magazi zimachepetsedwa.

Mankhwala olimbitsa thupi ali ndi zabwino zambiri pamankhwala ena ochepetsa lipid. Uku ndi kuthekera kolimbikitsa kuwonjezeka kwa kapangidwe kachulukidwe kakakulu ka lipoproteins (HDL) ndi kuchepa kwa triglycerides. Monga mukudziwa, gawo la lipid ndi "cholesterol yabwino", ndipo limakhudza bwino dongosolo la mtima. Awo kupanikizika kwambiri m'mwazi kumachepetsa mwayi wokhala ndi kupititsa patsogolo kwa matenda aheroscosis.

Malinga ndi radar, njira yayikulu yopanga michere ndi mapiritsi. Pulogalamu yawo yogwira, lipoprotein lipase, imayenda nayo ku chiwindi ikalowa m'magazi, yomwe imayambitsa kachulukidwe kake kakakulu ka lipid.

Dziwani kuti: ma fibrate samachiritsa zotsatira za njira ya atherosulinotic ndipo sangathe kuchotsa ma cholesterol akhazikika m'makhoma amitsempha. Mankhwalawa amangolepheretsa kugawa kwawo, kukula, komanso kupangika kwatsopano kwa kulowetsedwa ndikuwonongeka kwamafuta. Ichi ndichifukwa chake kudziwika koyambirira ndi chithandizo chamanthawi yake ndikofunikira.

Cyprofibrate: mungatenge bwanji ndi cholesterol yayikulu?

Mwa mawu akuti cholesterol pachikhalidwe amatanthauza otsika kachulukidwe lipoproteins. Awo kupanikizika kwambiri mu magazi kumawonjezera mwayi wa atherosulinosis ndi chitukuko cha trophic matenda, mtima matenda, sitiroko.

Zakudya zapadera ndi mankhwala amagwiritsidwa ntchito kuti achepetse milingo ya LDL m'magazi. Mapiritsi abwino kwambiri a cholesterol ndi ma statins, ma fibrate ndi zina zachilengedwe.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amaikidwa kuti achepetse LDL pazinthu zotsatirazi:

• Hypercholesterolemia yoyamba.
• Mabanja obadwa mwathupi.
• Hyperlipidemia IIa ndi madigiri a IIb malinga ndi Fredrickson.
• Chiwopsezo cha zovuta zamtima mu mtima mwa odwala omwe ali ndi mtima wamitsempha, matenda oopsa, okhala ndi mbiri yokhudzana ndi myocardial infarction kapena ischemic stroke.
• Dyslipidemia wosakanizika wazinthu zilizonse.

Mankhwala a Anticholesterol amagwiritsidwa ntchito ngati othandizira pawokha kapena ndi gawo la regimens zovuta. Kuti muchite bwino, kugwiritsa ntchito mankhwalawa kumaphatikizidwa ndi kukonza zakudya komanso kuchita masewera olimbitsa thupi.

Zotsatira zoyipa

Mankhwala ochepetsa cholesterol amaloledwa ndi odwala. Zotsatira zoyipa sizidutsa malire ovomerezeka. Mavuto omwe adachitika mwa odwala nthawi yoyesedwa, komanso kupsinjika kwa mwadzidzidzi akuwonetsedwa patebulo:

Mndandandawu siwachangu. Kuphatikiza apo, mankhwala aliwonse amakhala ndi zovuta zake. Zambiri pazandalama zomwe zakonzedwa kuti zigwiritsidwe ntchito zitha kupezeka muzowonjezera zomwe zimaphatikizidwa ndi mankhwalawo. Zotsatira zoyipa zimasonyezedwa malinga ndi gulu la WHO, pomwe:

• Nthawi zambiri (1 / 10-1 / 100).
• Osati kwambiri (1 / 100-1 / 1000).
• Pafupipafupi (1 / 1000-1 / 10000).
• Ochepa kwambiri (oposa 1/10000).

Mndandanda wamankhwala abwino kwambiri am'badwo watsopano

Mankhwalawa amagwiritsidwa ntchito popanga mankhwala a fibroic acid. Agawika m'mibadwo itatu, iliyonse yomwe imaperekedwa pamsika wamasitolo pansi pa mayina osiyanasiyana ogulitsa.

• Nthonje za m'badwo woyamba: clofibrate
• Fibates of 2 mibadwo: gemfibrozil, bezafibrat
• Fiber za m'badwo wachitatu: fenofibrate, ciprofibrate

Fenofibrate

Awa ndi mankhwala a m'badwo wotsiriza, wachitatu. M'mawu azachipatala, tsopano amatha kupezeka pafupipafupi pakati pa michere ina yonse. Amakhala ndi mbiri yotereyi chifukwa cha malo omwe amalembedwera - imalepheretsa kudziphatika kwa magulu ambiri am'magazi komanso tizigawo ting'onoting'ono ta magazi, tomwe timachepetsa kwambiri ngozi yamagazi. Njira yayikulu yochepetsera lipid-kuchepetsa, monga ma fiber ena, ndikuti imakhudza gawo loipa la cholesterol ndi LDL, kuchepetsa kuphatikizika kwake m'chiwindi ndipo, nthawi yomweyo, kumathandizira kukulira kwa cholesterol ya HDL - "yothandiza".

Ngati tikufanizira fenofibrate ndi mankhwala amibadwo ina, ndiye kuti ili ndi zowerengeka zazing'ono zomwe zimapangitsa. Kwambiri bioavailability komanso mosavuta digestibility. Mlingo waukulu patsiku ndi 200 mg. Ndikofunikira kumwa mankhwalawa mukudya. Mwanjira imeneyi, kuyamwa kwathunthu kwa mankhwalawa kumachitika.

M'mafakisi, omwe amafanana ndi omwe amagwira ntchito omwewo amaperekedwa, pansi pa mayina Lipantil, Tricor, Nolipax, Lipofen, Fenofibrat Canon.

Bezafibrat

Amapangidwa m'mapiritsi ndi muyeso wa 200 milligrams. Mosiyana ndi fenofibrate, iwo amatengedwa asanadye. Njira ya chithandizo ndi mwezi umodzi, ndiye kuti nthawi yopuma imapangidwa nthawi yofanana. Mankhwala awa a gulu la fibrate amadziwika ndi kukhudzika kwakukulu komanso kutulutsa msanga m'thupi.

Pamashelu ogulitsa mankhwala osokoneza bongo amathanso kupezeka pansi pa mayina a brand Besifal, Cedur, Oralipin.

Choline Fenofibrate

Ndi mankhwala osokoneza bongo omwe mwachindunji mu minofu amasinthidwa kukhala fenofibroic acid. Amalembera odwala omwe ali ndi mtundu wa III, IV ndi V hypercholesterolemia (malinga ndi gulu la Fredrickson). Mlingo wambiri watsiku ndi tsiku ndi 135 mg. Zosagwirizana ndi mowa.

Itha kupezeka pansi pa dzina la malonda la Trilipix.

Awa ndi mankhwala am'badwo woyamba wa fibrate. Pakadali pano, sigwiritsidwanso ntchito chifukwa chotsatira zoyipa zambiri.Kugwiritsa ntchito kwake kungayambitse cholestasis ya impso, mapangidwe amiyala mu hepatobiliary system ndikuchulukitsa kwa cholelithiasis.

Komanso motsutsana ndi kumbuyo kwa nthawi yoikidwiratu, minofu yam'mimba imavutika. Izi zimawonetsedwa ndi zotupa zosiyanasiyana za neuromuscular, myositis ndi myalgia. Odwala amatha kudandaula za kutopa kwakumbuyo, kufooka, ndi zizindikiro za kuledzera. M'mbuyomu (makamaka kumapeto kwa zaka za zana la 20), adalembera odwala omwe ali ndi zotupa za atherosulinotic zam'mimba, zotumphukira, komanso ziwongo.

Mayina amalonda amitundu yamtunduwu: Lipomid, Amotil, Lipavlon.

Zotsatira zoyipa ndi contraindication

Ziphuphu ndi mankhwala omwe amakhudza thupi. Chifukwa chake, amasankhidwa ndi dokotala wokhazikika atamuwunika kwathunthu. Asanaikidwe, muzikumbukira zolakwika zingapo pagululi, izi:

• Mafayilo sagwiritsidwa ntchito pochita ana. Amaphatikizidwa kwa ana.
• Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa samapangidwanso, popeza ali ndi mphamvu ya teratogenic ndipo amatha kulowa mkaka wa m'mawere.
• Hypersensitivity zimachitika mankhwala kapena zigawo zake.
• Odwala omwe ali ndi vuto la chiwindi kapena matenda a impso, makamaka ndi kulephera kwa aimpso.
• Odwala Omwe Amamwa Mowa Mopitirira Muyeso
• Odwala omwe ali ndi mbiri ya pancreatitis yovuta kapena yopweteka.

Ma fiber achilengedwe kulibe, onsewa ndi zinthu zopangidwa ndi mankhwala. Chifukwa chake, monga chinthu chilichonse chopangidwa, michere imakhala ndi zotsatira zoyipa. Komabe, ngati m'badwo wawo woyamba, mndandanda wazotsatira unali masamba angapo a malangizo, ndiye kwa omaliza, m'badwo wachitatu iwo unachepetsedwa kwakukulu komanso kutalika. Pamodzi ndi mankhwala ena am'badwo uno, Fenofibrate nthawi zambiri amadziwitsidwa ndi madokotala. Pogwiritsa ntchito chitsanzo chake, timaganizira zovuta zakubadwira m'badwo uno.

Kuwerengetsa kwamawonekedwe kunapangidwa chifukwa cha kutenga Fenofibrate. Phunziroli lidakhudza odwala 4389. Mwa iwo, odwala oposa 90% sanamve zotsatira zoyipa za mankhwalawa. 8,9% ya omwe adafunsidwa adazindikira kusasangalala kwam'mimba. 1.1% - kumva kufooka kwa minofu ndi kupweteka pamutu pang'ono. Kuphatikiza pazotsatira zoyipa izi, malangizo a ma fibrate amawonetsa zovuta zingapo zosowa - kuchepa kwa hemoglobin m'mitsempha yamagazi ndi zotupa pakhungu.

Kusiyana pakati pa ma fibrate ndi ma statins

Fibates ndi ma statin ndi magulu awiri osiyanasiyana a mankhwalawa, omwe ali ndi mitundu yosiyanasiyana yochitira zosiyanasiyana. Chifukwa chake, kufunsa funso - lomwe limakhala labwino, ma fiber kapena ma statin - silolondola. Kusiyanitsa kofunikira kwambiri pakati pa ma fiber ndi kuthekera kachitidwe pa triglycerides. Ili ndiye gulu lokhalo lamankhwala lomwe likuwonetsa katunduyu.

Magazi triglycerides: kutsimikiza, nthawi zonse ndi zaka komanso jenda, zomwe zimayambitsa kupatuka mu zizindikiro

Ma Statin ndi mankhwala omwe cholinga chake ndi kuchepetsa kuchuluka kwa cholesterol “yoyipa” ndikuwonjezera “zabwino”. Zitha kuwoneka kuti ma fiber amapanga zomwezo. Koma ayi, ma statins amachita mwachindunji pama cell a chiwindi ndikuletsa ma enzymatic machitidwe omwe amathandizira kapangidwe ka cholesterol. Ndi ma fibrate - imathandizira kuchotsedwa kwa cholesterol yoyipa m'magazi ndikuchepetsa kuchuluka kwa triglycerides.

M'zaka zaposachedwa, kafukufuku yemwe asayansi aku London adachita asonyeza kuti ma cellins amakhudzanso mtima wake, amawongolera kapangidwe kake ndi kagwiridwe kake. Pansi pa zochita zawo, kuchuluka kwa mtima wama hypertrophy kumachepa kwambiri. Musaiwale za momwe zimakhalira pakuyenda kwamitsempha yamagazi - kutanuka kwake kumachuluka, khoma lamitsempha limalimbitsa, ndipo mwayi wokhala ndi kachulukidwe kolesterol kokhazikika pa iwo umachepa kwambiri.

Malinga ndi mawerengero azachipatala ndi machitidwe, chithandizo chamankhwala cha statins chimachepetsedwa kwambiri cholesterol ikafika chizindikiro cha 7.4 mmol pa lita. Ngati lonjezoli lakwaniritsidwa mu mbiri ya lipid, ndiye pazochitika zonse, adokotala ayenera kupanga mankhwala ovuta ndi mitundu ingapo ya mankhwala. Nthawi zambiri, kuphatikiza kwa ma statins okhala ndi ma fibrate kumayikidwa.

Niacin kuti achepetse cholesterol yamagazi

Gulu la mankhwala

Mankhwala samangokhala ndi mphamvu yokhazikika pamatumbo am'mimba, komanso amawonetsa kutulutsa mphamvu. Kuchita bwino kotereku kumatheka chifukwa cha bifidobacteria mu kapangidwe kake kakuphatikizidwa kwa kaboni. Mankhwala amatha kupondereza zochitika za Proteus, Klebsiella, Shigella, Salmonella ndi Staphylococcus aureus.

Otsutsa-matenda zimachitika chifukwa cha njira za sorption wa bifidobacteria pa makala a malasha. Izi zimadzetsa kukhathamiritsa kwa yachilendo microbiocenesis m'mimba thirakiti. Mankhwala amapereka kutsegulitsanso njira mu mucous nembanemba ndipo amatha kuwonjezera kukana kwa thupi.

Mphamvu ya antitoxic imawonekera mofulumira. Zotsatira zake zimachitika chifukwa cha kufalikira kwam'matumbo ndi matumbo a bifidobacteria. Kuphatikizikako kumathandizira kubwezeretsanso kwa matumbo microflora, omwe pambuyo pake amalepheretsa kupatsirana kwa pathogen kwa mucous nembanemba.

Kwa akuluakulu

Ngati pali zizindikiro za kumwa mankhwalawa, angagwiritsidwe ntchito ndi odwala a gululi. Mankhwalawa amalekeredwa bwino, amakhudzidwa mukagwiritsidwa ntchito Mlingo. Kuongoleredwa ndi malangizowo sikuwuka. Mlingo wowonjezereka nthawi zina umatha kudzimbidwa.

Kusintha kwa Mlingo kwa okalamba sikofunikira. Mankhwala tikulimbikitsidwa kuti kumwedwa Mlingo zotchulidwa dokotala. Matenda a hepatatic komanso aimpso sikuti akuphwanya njira yogwiritsa ntchito mankhwalawa. Mankhwalawa amagwiritsidwa ntchito pafupipafupi.

Studifor nthawi zambiri amagwiritsidwa ntchito pochita ana. Mankhwala amalekeredwa bwino. Zotsatira zoyipa zomwe zili pambuyo pake sizigwiritsidwa ntchito. The zikuchokera pamaso pa zikuwonetsa ntchito akhoza kupatsidwa kwa ana a mibadwo yosiyanasiyana, palibe contraindication kutenga zikuchokera nthawi neonatal nthawi. Ndikofunika kukumbukira kuti mlingo uliwonse umawerengeredwa payekhapayekha.

Mlingo ndi Ulamuliro

Pulifor ya mankhwala tikulimbikitsidwa kuti imwe ndi chakudya. Pa matenda am'mimba komanso kusanza, mankhwalawa amatha kugwiritsidwa ntchito mosasamala kanthu za kudya.

Zomwe zimapangidwira mu kapisozi kapamwamba zimangotchulidwa kwa odwala azaka zopitilira 5. Makapisozi amatengedwa pakamwa, tikulimbikitsidwa kuti mumwe mankhwalawo ndi madzi okwanira kapena mkaka wokwanira mkaka.

Mankhwalawa, opangidwa ngati ufa, amatha kuperekedwa kwa ana m'nthawi yamatumbo, nkuwasakaniza ndi osakaniza osakanikirana ndi mkaka wa mayi. Kusakaniza kochokera kusakanikirana kuyenera kutengedwa pokhapokha pakutha kwathunthu kwa tinthu tomwe tikugwira.

Kwa pakati ndi kuyamwitsa

Probitor itha kugwiritsidwa ntchito panthawi yoyembekezera komanso yoyamwitsa. Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito musanabadwe. Palibe choletsa kwa amayi omwe amatenga nthawi imeneyi nthawi imeneyi.

Contraindication

Kulandila ndi koletsedwa kwa odwala omwe ali ndi hypersensitivity kwa omwe amagwira ntchito kapena othandizira pazinthu za mankhwalawo. Mankhwalawa sayenera kumwedwa ngati pakachitika zovuta zina. Kulandila kwa mapangidwe kuyenera kusiyidwa ngati chithandizo cha mankhwalawo sichikuwoneka pambuyo pa masiku 5 kuyambira pachiwonetsero cha makonzedwe.

Mlingo ndi Ulamuliro

Pulifor ya mankhwala tikulimbikitsidwa kuti imwe ndi chakudya. Pa matenda am'mimba komanso kusanza, mankhwalawa amatha kugwiritsidwa ntchito mosasamala kanthu za kudya.

Zomwe zimapangidwira mu kapisozi kapamwamba zimangotchulidwa kwa odwala azaka zopitilira 5. Makapisozi amatengedwa pakamwa, tikulimbikitsidwa kuti mumwe mankhwalawo ndi madzi okwanira kapena mkaka wokwanira mkaka.

Mankhwalawa, opangidwa ngati ufa, amatha kuperekedwa kwa ana m'nthawi yamatumbo, nkuwasakaniza ndi osakaniza osakanikirana ndi mkaka wa mayi. Kusakaniza kochokera kusakanikirana kuyenera kutengedwa pokhapokha pakutha kwathunthu kwa tinthu tomwe tikugwira.

Kwa akuluakulu

Mlingo woyenera wa odwala ndi ana opitirira zaka 7 ndi makapisozi awiri kapena mapaketi awiri kapena atatu kawiri patsiku. Kutalika kwa nthawi ya ntchito ndi mpaka masiku 7.

Kuti muchepetse kutsekula m'mimba, odwala akuluakulu amalangizidwa kuti atenge 2 mapiritsi a mankhwalawa pakadutsa mphindi 30 asanadye. Kutengera momwe wodwalayo alili, mlingo umatha kusintha. Kutalika kwa maphunziridwe ake kuyambira 1 mpaka 3 masiku.

Matenda osachiritsika, kapangidwe kake ndi mankhwala 3 kapena 1 mapaketi 1 kamodzi patsiku. Nthawi yovomerezeka imatsimikiziridwa payekhapayekha. Woopsa matenda, mlingo akhoza kuchuluka kwa makapisozi 6 mu Mlingo 2 wogawanika.

Ana a zaka zapakati pa 5 mpaka 7 amapatsidwa kapisozi 1 mpaka 4 pa tsiku. The pakati pakati Mlingo ayenera kukhala osachepera maola 2-3. Kutalika kwa maphunziridwe ake kuyambira 2 mpaka 5 masiku.

Ana opitirira miyezi isanu ndi umodzi akulimbikitsidwa kuti amwe mankhwalawa m'matumba, kumwa mankhwala ndi mapaketi atatu patsiku. Kutalika kwa maphunzirowa ndi masiku 2-3, ngati zizindikiro zimapitilira masiku 4-5.

Kwa pakati ndi kuyamwitsa

Amayi oyembekezera, ngati njira yolepheretsa kukula kwa zovuta pambuyo pa gawo la cesarean, khalani ndi kapisozi umodzi kapena paketi imodzi katatu patsiku. Njira yovomerezedwa iyenera kuyamba masiku 3-5 asanafike tsiku loti achitidwe opaleshoni. Pakatha masiku 2-7 atatha kulowererapo, makonzedwe akhoza kuyambiranso. Kutalika kwa ntchito kwa mankhwalawa amayikidwa payekhapayekha ndipo amayambira masiku 7 mpaka 10.

Pa nthawi yomwe muli ndi pakati pa 1 ndi 2 trimester, kapangidwe kake kangagwiritsidwe ntchito ngati pali umboni wovomerezeka. Mankhwalawa samabwezeretsa zovuta komanso samalowa mu zotchinga zina. Panthawi yoyamwitsa, imagwiritsidwanso ntchito ngati pali zizindikiro zovomerezeka.

Chithandizo cha Cholesterol Yapamwamba: Mndandanda wazithandizo Zothandiza

Mwa mawu akuti cholesterol pachikhalidwe amatanthauza otsika kachulukidwe lipoproteins. Awo kupanikizika kwambiri mu magazi kumawonjezera mwayi wa atherosulinosis ndi chitukuko cha trophic matenda, mtima matenda, sitiroko.

Zakudya zapadera ndi mankhwala amagwiritsidwa ntchito kuti achepetse milingo ya LDL m'magazi. Mapiritsi abwino kwambiri a cholesterol ndi ma statins, ma fibrate ndi zina zachilengedwe.

Ma Statin a Cholesterol

Gulu la mankhwala atsopano omwe zochita zawo zimafuna kutsitsa LDL m'magazi. Zizindikiro ndi zovuta zake ndizodziwika kwa mankhwala onse a hypocholesterolemic. Oyimira odziwika ndi mankhwala omwe afotokozedwa pansipa.

Statin amatengedwa ngati mankhwala osankhidwa mankhwalawa mtundu wa dyslipidemia. Zida izi ndizotetezedwa poyerekeza ndi antchito ena.

Atorvastatin

Amapezeka m'mapiritsi okhala ndi filimu yokhala ndi yogwira pophika 10, 20 kapena 40 mg. Imasankha mosavomerezeka ma HMG-CoA reductase, motero imasokoneza zochitika zomwe zimapangitsa kuti pakhale kupangika kwa ma steroid, kuphatikiza cholesterol. Amachotseredwa ndi bile, ochepa amasiya thupi ndi mkodzo.

The achire voliyumu ya mankhwala zotchulidwa 10 mpaka 80 mg patsiku. Mlingo wofunikira umatsimikiziridwa payekhapayekha, kutengera mulingo wa LDL m'magazi a wodwalayo komanso momwe amathandizira pochira.

Mapiritsi amatengedwa 1 nthawi patsiku, mosasamala chakudya. Chithandizo chimayamba ndi mlingo wochepa, masabata awiri atachiritsidwa, amatsogozedwa ndi data yoyesedwa yamagazi.

Kuchuluka kwa zotsatira kumachitika mwezi umodzi pambuyo poyambira chithandizo.

Chithandizo cha cholesterol yayikulu chimagawidwa mu filimu ya aluminium foil. Phukusi limodzi limatha kukhala ndi matuza mpaka asanu a mapiritsi 7. Zokwera mtengo. Mtengo wa mankhwala umayamba kuchokera ku ma ruble a 180 ndipo umatha ndi chikwi chimodzi pazipikisano zazikulu ndi mulingo. Amamasulidwa pa mankhwala.

Simvastatin

Amapangidwa pamapiritsi a 10 ndi 20 mg. Zomwe zimagwira ndi dzina la mankhwalawa ndizofanana. Chogulikacho ndi chophatikizika ndi opadra wobiriwira. Ili ndi chiyambi chopangidwa. Chochitikacho chimadalira chopinga cha HMG-CoA reductase ndi kusokonekera kwa kaphatikizidwe ka cholesterol. Amapukusidwa makamaka m'matumbo ngati gawo la bile. Pang'ono ndi impso.

Chithandizo chimayamba ndi 10 mg, kamodzi, musanakagone. Pa mankhwala, kuchuluka kwa mankhwalawa kumasinthidwa. Kwa odwala ambiri, 20 mg ndi yokwanira kukwaniritsa zotsatira zovomerezeka, koma ngati pangafunike, mlingo wake ungakhale 80 mg. Kuchepetsa kwakukulu kwa LDL m'magazi kumatheka mwezi umodzi atayamba kumwa mankhwalawo.

Mapiritsi amagawidwa m'matumba a zidutswa 10, 2 kapena 3 pa paketi iliyonse. Chotulutsidwa ndi mankhwala. Mtengo umayambira ku ma ruble 50, ndipo mtengo wake wokwera umafikira ma ruble 600.

Rosuvastatin

Mankhwala ndi gulu la ma statins, omwe amapezeka pa mlingo wa 5, 10, 20 ndi 40 mg piritsi lililonse. Zomwe zimagwidwa zimaperekedwa mwa mawonekedwe a calcium wa rosuvastatin. Makinawo amafanana ndi mankhwala ena a gululi (zoletsa za HMG-CoA reductase). Amawachotsa ndowe (90%) ndi kwamikodzo dongosolo (10%).

Mankhwala amatchulidwa 1 nthawi patsiku. Kutumizira koyamba ndi 5 mg. Pambuyo pake, imayenera kuwongoleredwa malinga ndi zotsatira za mbiri ya lipid. Kusintha kwa mankhwalawa sikunachitike kuposa milungu inayi kuyambira chiyambi cha mankhwala.

Kupatulako ndi cholesterolemia yayikulu, yomwe imafuna kuti achepetse kwambiri lipid ndende. Mwambiri, zotsatira zabwino zimatheka ndi 20 mg. Piritsi imatengedwa popanda kutafuna, kutsukidwa ndi madzi.

Chakudya sichimakhudza mayamwidwe ndikuyenda bwino kwa mankhwalawa.

Mankhwalawa amagawidwa m'matumba a mapiritsi 10, 14, 15, 30 kapena 60. Phukusili limatha kukhala ndi mbale 6. Mtengo wapakati wa mankhwalawo ndi ma ruble 300-400.

Gemfibrozil

Amachepetsa kuchulukitsidwa kwamafuta am'mafuta mwa chiwindi ndipo amalepheretsa zotumphukira za lipolysis. Amawonjezera kuchulukana kwa cholesterol mu kapangidwe ka bile. Kuchulukitsa kuchuluka kwa HDL m'magazi. Momwe zimachepetsera chiopsezo chokhala ndi myocardial infarction ndi zina za ischemic pathologies zomwe zimachitika chifukwa cha kusintha kwa ma atherosselotic m'matumbo.

Amapezeka m'mapiritsi a 0,3 g, komanso mapiritsi okhala ndi mulingo wa 0,45 ndi 0,6 magalamu. Mlingo umodzi ndi 0,45 g, kuchulukitsa kumachitika kawiri patsiku. A zazikulu zimachitika pambuyo masabata 4-6 kuyambira chiyambi cha mankhwala. Chipangizocho sichofalikira chifukwa chofunikira kugwiritsidwa ntchito kawiri komanso kukhalapo kwa zotsatira zoyipa. Mtengo muma pharmacies opezeka pa intaneti umachokera ku 800 mpaka 1600 rubles.

Fibroic acid yokhala ndi cholesterol yotsitsa mankhwala. Kugwiritsidwa ntchito moyenera masiku ano. Zoyambitsidwa kumayambiriro kwa zaka za m'ma 1900, koma sizinatayike mpaka pano. Dzina lachiwiri ndi lochokera. Pali mitundu pafupifupi 10 ya mankhwala, omwe ambiri mwa iwo ndi mankhwalawa anayi.

Lipantil 200 M

Mankhwala ozikidwa pa micenized fenofibrate. The kuchuluka kwa yogwira mankhwala 1 kapisozi ndi 200 mg. Zotsatira zake zimatengera kukondoweza kwa RAPP-alpha receptors. Imafufutidwa kudzera mu impso mu mawonekedwe a metabolites yogwira.Chimagwiritsidwa ntchito makamaka pochiza matenda oopsa a hyperlipidemia. M'mitundu yachiwiri yamatendawa, imangotchulidwa pokhapokha ngati chithandizo chazomwe chimayambitsa matenda.

Lipantil 200 M imatengedwa kapisozi imodzi patsiku, makamaka ndi zakudya. Kuchiza kumachitika motsutsana ndi maziko a zakudya zopatsa lipid. Kuwunika bwino kumapangidwa miyezi itatu itatha kudya. Ndi kuchepa kosakwanira kwa milingo yokhala ndi kachulukidwe kochepa kwambiri, wodwalayo amapatsidwa chithandizo chowonjezera kapena gulu la anticholesterolemic mankhwala limasinthidwa.

Makapu 10 amapezeka mu chithuza. Ma CD amatha kukhala ndi magawo 20 kapena 30 a mankhwalawa. Mtengo wake ndi ma ruble 850-1000 pa paketi iliyonse ndi mbale zitatu. Kuphatikizidwa ndi mndandanda wa mankhwala ofunikira (mankhwala ofunikira ndi ofunikira). Ndi genen fenofibrate.

Zithandizo Zachilengedwe za Cholesterol (Zowonjezera)

Izi ndizophatikiza pazachilengedwe zomwe zimakhudza kagayidwe ka munthu, kuthamanga kapena kuchepetsa zina. Nthawi yomweyo, homeopathy sagwira ntchito mankhwala, sasintha masinthidwe achilengedwe achilengedwe.

Malinga ndi opanga, zowonjezera zakudya zimatha kuchepetsa kuchuluka kwa LDL m'magazi. Komabe, zithandizo zotere sizipitilira mayesero azachipatala omwe mankhwalawa amawagwiritsa ntchito. Mphamvu ya kukonzekera kwazitsamba sikunayambike.

Kutsika mtengo komanso kwabwino, malinga ndi omwe amagawa, mitundu ya zitsamba imangokhala yopanda ntchito, komanso yopweteketsa.

Amapangidwa kuchokera kuzinthu zopangika za chigamba cha shrimps, lobster, lobster. Makina amachitidwe amafanana ndi aubweya wa chinthu chosakhala chamimba (Polysorb MP).

Tinthu tating'onoting'ono tomwe timateteza ku crustacean mu mawonekedwe amphindi ndi ma resion anion, amatha kuthekera kumangirira ndikumachotsa ma ayoni azitsulo, poizoni, komanso ma radio isotopes kuchokera m'thupi. Kugawidwa m'matumba a zidutswa zana.

Malamulowa ndi makapisozi atatu katatu patsiku. Nthawi - mwezi umodzi. Mtengo wapakati ndi ma ruble 500.

Kukonzekera kokhala ndi ciprofibrate

Dzina lamalonda lamankhwala, chinthu chogwira ntchito chomwe ndi chiprofibrate, ndi Lipanor. Imapezeka mu kapisozi kapangidwe kake, iliyonse kamene kamakhala ndi 100 mg yogwira mankhwala.

Tsiprofibrat moyenera amathana ndi cholesterol yamwazi yokwezeka. Monga mankhwala ena ochokera ku gulu la ma fiber, pamafunika chisamaliro chapadera kuti mugwiritse ntchito. Simungagwiritse ntchito mankhwalawa popanda mankhwala a dokotala. Kusankhidwa kwa Mlingo kumachitika pokhapokha ngati wodwalayo alili komanso kuopsa kwa matendawa.

Vita Taurin

Kuphatikizika kwa amino acid zomera. Malinga ndi opanga, amachepetsa cholesterol bwino, amatulutsa chimbudzi, amatulutsa chimbudzi. M`pofunika kumwa mankhwala piritsi 1 2 pa tsiku, njira ya mankhwala 2 miyezi. Kugawa m'matumba a 100 makapisozi. Mtengo - 1500 rubles.

Malipiro azamasamba

Zosakanikirana za mankhwala zimagwiritsidwa ntchito kukonza mawonekedwe a lipid. Ayenera kugwiritsidwa ntchito mwanjira ya decoction. Zipangizo zofunikira kukonzekera kwake ndi zitsamba monga clover wokoma, nettle, wort wa St. John, yarrow, dogrose, timbewu, tchire, fulakesi, hawthorn, oregano. Kulowetsedwa kwa Garlic kumathandizira kuchepetsa mafuta m'thupi.

Njira yokonzekera infusions ndi yosavuta. Ikani supuni ziwiri zitatu za matebulidwe osaphika kapena adyo (adyo) mu thermos, ndiye kutsanulira malita 0,5 a madziwo, kuphimba ndi kusiya usiku.

M'mawa, chinthucho chimasefedwa, ndikuchotsa tizigawo tating'onoting'ono tomwe timakonzedwa, ndipo kumatenthetsa ndi kutentha kovomerezeka ndikumwa kuledzera kawiri pa tsiku.

Kuchuluka kwa kulowetsedwa kwazitsamba ku phwando ndi 200-250 ml, adyo - supuni 2-3.

Chinsinsi cha msuzi ndi ichi: zosaphika zomwe zimagwiritsidwa ntchito ndi 24 magalamu zimathiridwa ndimadzi ozizira, kuyatsidwa moto ndikuwiritsa kwa mphindi 15-30.Pambuyo pa izi, kapangidwe kake kamakopekedwa, kusefedwa ndi kutengedwa chimodzimodzi ndi infusions. Fomu ya Mlingo imawerengedwa ngati yokhutira kwambiri ndipo imafuna nthawi yochepa yokonzekera.

Maganizo a Dotolo

Kuyeretsa thupi la zolimbitsa zam'mimba zochepa kumatha kuchitika pogwiritsa ntchito mankhwala asayansi, komanso kugwiritsa ntchito mankhwala azikhalidwe, zakudya zamagulu, komanso zakudya.

Kuchita bwino kumawunikiridwa ndi zotsatira za kuyesa kwamwazi wamagazi. Therapy iyenera kuchitika moyang'aniridwa ndi dokotala.

Kudzipangira nokha sikulimbikitsidwa, chifukwa popanda thandizo la katswiri munthu sangathe kusankha mankhwalawa ndikuwunika momwe amathandizira.

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Chithandizo cha mapiritsi a cholesterol ambiri

Cholesterol okwera m'magazi ndi chifukwa chochitirapo kanthu. Zikatero, njira zina zachithandizo zimayikidwa, komanso malingaliro pa moyo ndi zakudya zoyenera.

Njira zothandiza zobwezeretsera zizolowezi monga kuphatikiza kumwa mankhwala.

Mapiritsi a cholesterol amathandiza kuchepetsa chiopsezo chotenga matenda omwe angatheke komanso kupewa zovuta.

Momwe mungabwezeretsere zisonyezo kukhala zofananira

Ndi cholesterol yowonjezereka, pali mwayi waukulu wodwala matenda a mtima, matenda a chiwindi kapena impso, vuto la endocrine, etc. Pankhaniyi, chithandizo cha cholesterol chachikulu chitha kugawidwa m'njira ziwiri zazikulu:

• mankhwala
• mfundo zosagwiritsa ntchito mankhwala osokoneza bongo

Pochiza ndi mapiritsi, izi zimatheka:

• cholesterol imachotsedwa mkati mwa maselo, ndipo kubwereza kwa chiwindi kumachepetsa.
• m'matumbo, chotchinga chimapangidwa kuti chilowetse mafuta m'thupi,
• mtima umayenda bwino
• milomo imasweka ndikuwonongeka kwawo kumachitika
• cholesterol "choyipa" chimachotsedwa,
• magazi amayeretsedwa,
• kuchuluka kwa triglycerides kumayendetsedwa,
• HDL (lipoproteins yapamwamba) imachuluka
• Kapangidwe ka DNA kamakonzedwa motero mitundu yamtundu wa matenda imathandizidwa.

Mosakayikira, mothandizidwa ndi mankhwala osokoneza bongo, mutha kukwaniritsa zotsatira zabwino ndikuchepetsa magwiridwewo ntchito pamiyeso yoyenera. Kupatula izi, pali malingaliro ena oti, mogwirizana, amangowonjezera mwayi wopambana. Pankhaniyi, muyenera kutsatira malamulowa:

1. Khazikitsani dongosolo lazakudya zopatsa thanzi, kupatsa thanzi chakudya chopatsa thanzi. Ndikulamulira mosamala ma calorie olowa mthupi, simungangochepetsa thupi komanso kukwaniritsa mawonekedwe okongola, komanso othandizira kukonza thanzi.
2. Zochita zolimbitsa thupi ziyenera kuchitidwa molingana ndi kuthekera kwawo ndi umunthu wawo. Komabe, ngakhale kupezeka kwa matenda enaake, adynamia ili ndi zovuta, motero onetsetsani kuti mwawonana ndi dokotala za zomwe mungachite pochita masewera olimbitsa thupi komanso kuchuluka kwa katundu.
3. Ngati mukuti "ayi" ku mowa ndi kusuta, mutha kuzindikira kusintha kwakukulu mu mawonekedwe a uric acid metabolism, kuchuluka kwa zinthu za gulu lankhondo la antiatherogenic, kuchepetsedwa kwa zovuta zamtima ndi kuwoneka kwa mavuto obwera chifukwa chomwa mapiritsi. Kusintha kotereku ndikothandiza pakuchepetsa mafuta m'thupi.

Kugwiritsa ntchito njira zina zochiritsira kumathandizira pokhapokha kusintha kwapadera kwa mafuta m'thupi, komanso ngakhale mutamwa mankhwala osokoneza bongo.

Mapiritsi

Mutha kumwa mapiritsi a cholesterol yayikulu pokhapokha mutakambirana ndi adokotala. Pankhaniyi, njira zodzidzipangira nokha sizololedwa, pomwe zotsatira zake sizingakhale zambiri, koma, m'malo mwake, kuwoneka kwa mavuto ena azaumoyo.

Mu pharmacology yamakono, mankhwala osiyanasiyana amatulutsidwa omwe amayeretsa ziwiya zokhala ndi lipid yambiri komanso kuchepetsa kuchuluka kwa lipoproteins ochepa.Pankhaniyi, mndandanda wamagulu a mankhwala ochepetsa cholesterol yamagazi amawoneka motere:

• ma statins
• mafupa
• cholesterol mayamwidwe zoletsa,
• niacins
• kwachilengedwe zowonjezera.

Gulu lirilonse limakhala ndi zake ndi njira zopangitsira cholesterol yayikulu. Ndizofunikanso kudziwa kuti kuphatikiza kwathunthu kugwiritsa ntchito mtundu uliwonse ndiko kupezeka kwa munthu yemwe ali ndi vuto lakupanga zinthu.

Mwinanso mankhwala omwe ali mgululi ndi abwino kwambiri pamankhwala omwe mumalandira. Izi zikufotokozera kutchuka kwawo kwapamwamba kwambiri. Akakhala m'thupi, amayamba kuletsa ma enzyme omwe amachititsa kuti mafuta a chiwongo azikwaniritsidwa.

Izi zimathandizira kutsika kwa ma lipoproteins otsika kwambiri, chifukwa amasiya kupanga. Kuphatikiza apo, mankhwalawa alibe vuto lililonse ku chiwindi.

Kutengera ndi kuyamba kwa kupanga mankhwala ndi nthawi yogwiritsira ntchito mankhwala, magulu anayi am'badwo atha kusiyanitsidwa, omwe muphunzira zambiri pansipa.

M'badwo woyamba

Mankhwala a m'badwo woyamba amakula kwambiri matenda oopsa a lipoprotein ("abwino" cholesterol), omwe mosakayikira amakhudza thanzi. Komanso, mukamamwa, kuchuluka kwa lipoproteins otsika kwambiri kumachepa, ndipo nthawi yomweyo, chiwopsezo chokhala ndi zovuta zotheka zimachepa.

M'badwo wachiwiri

Woimira wochititsa chidwi m'badwo wachiwiri ndi Fluvastatin. Awa ndi omwewo omwe amachepetsa lipid ndikuwachepetsa.

Izi zikutanthauza kuchepa kwa chiwerengero cha LDL, ndipo kutchulidwa kumatha kuwonekera patatha masabata awiri. Komabe, mankhwalawa, monga mankhwala am'mbuyomu, ali ndi zotsutsana zambiri komanso zoyipa.

Zinali izi zomwe sizimalola kuyikira chida ichi.

M'badwo wachitatu

Atorvastatin ndi Ceristatin amatenga malo owongolera m'badwo wachitatu wa mankhwala.

M'badwo wachinayi

Uwu ndi m'badwo watsopano wamankhwala omwe aphunziridwa mokwanira pano ndipo ndi mankhwala abwino kwambiri kuti athetse ziwopsezo za atherosselotic, kuchepetsa chiopsezo cha thrombosis, komanso kuyeretsa mitsempha ya magazi ndikuwongolera mawonekedwe a khoma lamitsempha. Mankhwalawa amapereka zabwino zabwino ndipo cholinga chake ndi kuchepetsa magazi m'thupi, kuchepetsa mwayi wokhala ndi zovuta zamtima ndi kufa chifukwa cha zovuta zomwe zingachitike. Amalekereredwa bwino ndi odwala ndipo samapereka zovuta zoyipa.

Mapiritsi ochepetsa cholesterol amapezeka mosiyanasiyana, kutengera kuuma kwa mkhalidwe wa wodwalayo. Popeza mankhwala ndi otetezeka, angagwiritsidwe ntchito ngati mankhwala kwa nthawi yayitali.

Mankhwala a Statin ali ndi zinthu zingapo zofunika kwambiri:

• letsa kukula kwa magazi kuundana,
• khalani otentha kwamtsempha wamagazi,
• kupewa yotupa mu mtima khoma.

Ndipo monga momwe ziliri kale, zotsatira zotere zimachepetsa chiopsezo chotumphukira kwa cholembera cha atherosselotic ndi mapangidwe a kutupa pamalo a magazi omwe adagwa, omwe angayambitse kuphwanya kwa myocardial kapena stroko. Komabe, ngakhale mankhwala amphamvu komanso odalirika kwambiri amatha kukhala olakwika, motero mothandizidwa ndi kusanthula, kuyang'anira mosamala ma enzyme m'chiwindi ndikofunikira.

Magulu ena a mankhwala osokoneza bongo

Muthanso kuunikiranso magulu ena angapo a mankhwala omwe amatha kuyeretsa magazi, ndikuthandizanso kuchepetsa cholesterol pazoyenera zovomerezeka.

Ngati titha kunena za kuchuluka kwa mapiritsi onse a cholesterol, titha kusiyanitsa kutchulidwa kwawo, komwe kumachepetsa kuchepa kwa minyewa yamtima, kukonza rheology yamagazi, kumasuka ndikukula kwa khoma lamitsempha, komanso kusunga kukula kwokhazikika kwa zolembera za atherosselotic. Zonsezi ndizabwino kuti tipewe kuchitika kwa sitiroko, ischemia, myocardial infarction ndikuchepetsa kukula kwa atherosulinosis. Zomwe mankhwala oti mugwiritse munthu m'modzi anganene kwa dokotala, pomwe phwando limaperekedwa.

Mndandanda wa mankhwala abwino kwambiri m'gulu la fibrate kuti muchepetse cholesterol yamagazi

Matenda a atherosclerosis akukhala matenda ofala tsiku lililonse. Zimachitika chifukwa cha kuchuluka kwa lipoprotein otsika kwambiri komanso otsika kwambiri omwe amakhala pamakoma amitsempha yamagazi, kuchepetsa kupezeka kwawo.

Mapangidwe oterowo amatchedwa cholesterol plaques, mapangidwe awo amatha kusungunuka kokha ndi mafuta achilengedwe ndi ma sol sol.

Chimodzi mwazomwe mankhwala amapatsidwa kuti achulukitse cholesterol ndikuchepetsa chiopsezo cha magazi ndi mafupa - mankhwala, mndandanda womwe mpaka pano amatenga zinthu zingapo. Munkhaniyi tiona mwatsatanetsatane magwiridwe amachitidwe awo ndikupanga mankhwala abwino kwambiri omwe achititsa chidaliro cha madokotala ndi odwala kwazaka zambiri.

Malo osungira

Mankhwalawa amagulitsidwa kwa anthu kudzera pamaneti am'misika pamsika waulere. Mankhwala ziyenera kusungidwa pa kutentha osaposa 10 digiri. Nthawi yosungirako - chaka chimodzi kuyambira tsiku lopangidwa.

The Probifor ya mankhwala amatengedwa ngati mawonekedwe omwe amatsimikizira kayendedwe ka matumbo microflora. Mankhwalawa ali ndi chiwerengero chokwanira cha ma analogu omwe ali ndi machitidwe ofanana. Mankhwalawa amawonetsedwa monga mankhwala, koma tikulimbikitsidwa kuti mankhwalawo asinthidwe pambuyo pofunsa dokotala.

Mankhwala Sporobacterin ali ndi zotsalira zazamoyo. Kuphatikizikako kumawonetsera zotsatira zoyipa komanso zolimbitsa thupi. Mankhwalawa ndi otetezeka kwambiri komanso ogwira ntchito. Mukasunga, pamafunika kutentha kwapadera.

Lactobacterin ndi mankhwala osokoneza bongo omwe zochita zawo zimangobwezeretsanso microflora yachilengedwe. Ubwino wa kapangidwe kameneka ndikusinthidwa kwamitundu yosiyanasiyana yamasulidwe. Mankhwalawa amapangidwa ndi makampani azachipatala amomwe amapangira, mapiritsi, kuyimitsidwa ndi ufa. Mankhwalawa amalekeredwa bwino, zochitika zoyipa machitidwe amakono sizinalembedwe.

Kaputeni wa phenootic wopangidwa kuti abwezeretse microflora yamatumbo. Ntchito kuthana ndi zotupa zosiyanasiyana za bakiteriya, zogwira ntchito mu candidiasis.

Zochita za mankhwala zimakhazikika pakubwezeretsa matumbo microflora. Nthawi zambiri amagwiritsidwa ntchito pofuna kuchiza dysbiosis yamatumbo mwa odwala azaka zosiyanasiyana.

Njira yamachitidwe

limagwirira a zochita za fibrate

Atherosulinosis ndi matenda osachiritsika omwe amatsogolera kulumala komanso kufa msanga. Ichi ndi mwatsatanetsatane matenda omwe amakhudza mizere yayikulu yonse yamagazi ndi kudzikundikira kwa cholesterol mwa iwo. Myocardial infaration ndi matenda am'mimba ndizovuta zakupha za atherosclerosis, ndikupha anthu mamiliyoni padziko lonse lapansi. Atherosclerosis imayambitsa kukula kwa angina pectoris, kugunda kwa mtima, kuchepa kwa phokoso, ngozi ya pachimake ya ubongo.

Hypolipidemic wothandizira akuwonetsedwa:

• Anthu omwe ali ndi cholesterol yayikulu magazi,
• Kukhala ndi mbiri yolemetsa yabanja
• Ndi kusathandiza kwa chakudya chochepa cholesterol.

Makina a zochita za fibrate ndi kuchepa kwa enzyme - lipoprotein lipase, yomwe imagwetsa LDL ndi VLDL. Kukumana kwa HDL m'magazi kumakwera, kagayidwe kachakudya ka chiwindi kamathandizika, mafuta a metabolism amafulumira, chiwopsezo cha kukhala ndi atherosulinosis chimachepa.

Imawongolera dyslipidemia ndikuchita zina. Amachotsa ma radicals omasuka, ma anticoagulants, ndipo amatulutsa thupi. Ziphuphu zimathandizira kulimbitsa makoma amitsempha yamagazi ndikuchepetsa kuuma kwa zizindikiro zazikulu za kutupa.

Fibratotherapy pamodzi ndi nicotinic acid, ma statins ndi bile acid sequestators amachepetsa kufa kwa matenda a mtima ndi stroko.

Mankhwala osokoneza bongo omwe ali mgululi amakhala odziwika bwino komanso odziwika bwino ndi thupi. Mothandizidwa ndi fibrate, kaphatikizidwe ka triglycerides kamachepa, ntchito ya kuphwanya cholesterol imawonjezeka, ndipo njira yake yopangidwira imalephereka. Mankhwala amasankhidwa malinga ndi chiwembu china ndipo nthawi zambiri amaphatikizidwa ndi zinthu za gulu lofananira.

Filates imatenga nthawi yayitali: mwezi kapena kupitirira. Dokotala yemwe amatenga mankhwala amapatsa mapiritsi 2-3 patsiku kwa odwala. Kumwa mankhwalawa kuyenera kuphatikizidwa ndi chithandizo chamankhwala ndikuyang'anira ma lipids am'magazi nthawi zonse. Odwala ayenera kuthetseratu zakudya zomwe zimakhala ndi cholesterol ndi mafuta ena azinyama kuzakudya zawo za tsiku ndi tsiku. Kuti muimitse kukula kwa machitidwe a pathological, ndikofunikira kutsatira mfundo zoyambirira za zakudya zoyenera.

Oyimira akuluakulu a gulu lazachipatala awa ndi awa:

1. "Clofibrate" ndi mankhwala othandiza kwambiri omwe ali ndi ntchito yotsitsa lipid. M'mbuyomu, mankhwalawa adalembedwa kwa odwala omwe ali ndi matenda a coronary, ubongo, zotumphukira, matenda ashuga angiopathy, retinopathy, mitundu yosiyanasiyana ya dyslipidemia. Clofibrate adagwiritsidwa ntchito prophylactically kwa cholowa kapena hypercholesterolemia. Koma tsopano madotolo asiya kumuyika wodwala. Izi ndichifukwa cha kukulitsa zovuta zoyipa m'masiku oyamba kugwiritsa ntchito. "Clofibrate" ndi chowonjezera cha intrahepatic cholestasis, kupangidwa kwa ndulu ndi kuchulukitsa kwa matenda a ndulu.Mukamamwa mankhwalawa, odwala amatenga myositis kapena matenda ena am'mitsempha, matenda am'mimba. Odwala amadandaula za kugona, kufooka, malaise wambiri, kupweteka kwa minofu, kuwonda. Mayina amalonda a mankhwala: "Lipomid", "Amotril", "Lipavlon".
2. Gemfibrozil ilinso ndi zovuta zambiri. Zimapangidwa m'mapiritsi ndi mapiritsi a 450 ndi 650 mg. Mankhwalawa amagwiritsidwa ntchito kawiri pa tsiku kwa 600 mg kapena kamodzi 900 mg. Kutalika kwa chithandizo ndi miyezi ingapo. The achire zotsatira za mankhwala kumawonekera pokhapokha ngati ntchito kwa nthawi yayitali. Njira zofala kwambiri za gululi ndi: "Liposide", "Dopur", "Gavilon".
3. "Bezafibrat" amachepetsa kuchuluka kwa cholesterol ndi triglycerides m'mwazi ndikusiya thupi la munthu mwachangu. Mankhwala amamasulidwa pamapiritsi a 200 mg. Imwani mapiritsi musanadye kwa masiku 30, pumulani kwa mwezi umodzi, kenaka ibwerezaninso maphunziro. Zochokera ku "Bezafibrat" zimaphatikizapo "Bezifal", "Cedur", "Oralipin".
4. "Ciprofibrate" - mankhwala omwe amapezeka nthawi yayitali.
5. "Fenofibrate" imatha kusintha zomwe zili lipid mthupi. Ndi othandizira kutsitsa lipid-ponseponse polimbana ndi dyslipidemia ndi insulin kukana. Fenofibrate imalembedwa kwa anthu omwe ali ndi HDL yotsika komanso high triglycerides. Kuphatikiza pa kuchepetsa lipid-kuchepetsa, mankhwalawa ali ndi mitundu yambiri yosakhala ndi lipid: anti-yotupa, antioxidant, anticoagulant, tonic. Odwala nthawi zambiri amapatsidwa Lipantil, Lipofen, ndi Nolipax.

Mndandanda wama pathologies omwe akatswiri amapereka mankhwala kuchokera ku gulu la fibrate:

1. Hypertriglyceridemia,
2. Congenital kapena dyslipidemia,
3. Shuga mellitus - endocrinopathy, yowonetsedwa ndi shuga wambiri chifukwa chosakwanira kukhala ndi insulin,
4. Gout ndi matenda a kagayidwe kamene urate wake umayikidwa m'malo olumikizirana mafupa,
5. Nodular xanthomatosis - kuyika kwa cholesterol mwa mawonekedwe a zophatikizika pakhungu,
6. Metabolic syndrome - kusokonezeka kwa metabolic komwe kumabweretsa kukula kwa matenda a mtima,
7. Kunenepa kwambiri - kunenepa kwambiri kwamafuta m'thupi, minofu ndi ziwalo,
8. Atherosulinosis ndi mawonekedwe a lipids pamakoma a bedi lamitsempha.

Mndandanda wa mapiritsi amakono a cholesterol

Cholesterol okwera amawonedwa kuti ndi chinthu chomwe chimawononga kwambiri thanzi la munthu. Zomwe zimapezeka m'magazi a organic m'magazi zimatengera matenda angapo, omwe ambiri ndi atherosulinosis.

Kuchepetsa kuchuluka kwa cholesterol yamagazi kumatheka pogwiritsa ntchito mankhwala, zomwe zimakhazikika ndi mankhwala apadera. Onani zomwe mapiritsi a cholesterol ali pamsika wamakono komanso momwe amagwirira ntchito.

Kodi mapiritsi a cholesterol ndi ati?

Pali magulu angapo a mankhwala omwe amagwiritsidwa ntchito pochepetsa cholesterol:

1. Fibates. Amakhala m'gulu la mankhwala ochepetsa lipid omwe amachepetsa kuyamwa kwamagawo ena amafuta m'magazi. Mankhwala am'magulu amapanga lipids yamagazi ndikuchepetsa chiopsezo cha matenda a mtima ndi atherosulinosis. Palinso zovuta zina - mankhwalawa kuti muchepetse cholesterol imabweretsa zotsatira zoyipa, ndipo mphamvu yake imakhala yotsika poyerekeza ndi ma statins.
2. Madera Amadziwikanso ngati mankhwala opatsirana a lipid, koma njira yoletsa mafuta acid imakhazikitsidwa chifukwa cha kuletsa kwa HMG-CoA reductase - chinthu chomwe chimayambitsa biosynthesis ya cholesterol m'chiwindi. Njira zothandiza kwambiri pakati pa omwe alipo.
3. Otsatira a bile acid. Zoyenera kuletsa kuyamwa kwa cholesterol m'mimba. Amachetsanso kugaya zakudya zopindulitsa pazinthu ndi zinthu - chitsulo, calcium, antioxidants, ndi zina zambiri.Zotsatira zoyipa zimawonekera mu mawonekedwe amisala am'mimba.
4. Ezetemib. Chida ichi chitha kugwiritsidwanso ntchito kuchepetsa cholesterol, koma kafukufuku wasonyeza kuti sikuti mwanjira iliyonse amachepetsa chiopsezo cha kufa chifukwa cha matenda amtima oyambitsidwa ndi cholesterol yayikulu m'magazi.

Dziwani kuti mankhwala ochepetsa mafuta m'thupi m'magazi achilengedwe (chomera) sakhala pamsika.

Kamodzi m'zaka zochepa, ndalama zotsatsa zilizonse zimawonekera, koma pakapita kanthawi zimangosowa msika pomwe makasitomala akukhulupirira kuti chida chatsopanocho sichibweretsa phindu lililonse.

Cholesterol palokha siyowopsa - imatenga nawo mbali popanga maselo a cell ndi minofu, komanso imathandizira kupanga ma neurotransmitters.

Pofuna kuchepetsa kuchuluka kwa cholesterol yogaya m'magazi, mutha kugwiritsa ntchito mavitamini, mwachitsanzo - beta-carotene, vitamini E ndi mavitamini athunthu a vitamini.

Kugwiritsa ntchito ma statins kuti muchepetse cholesterol

Tisanaganizire mankhwala aliwonse a cholesterol, timalimbikitsa kuganizira za gulu la pharmacological lama statins.

Zotsatira za pharmacodynamic zotsatirazi zikuwonetsedwa mu malangizo a mankhwala a gululi:

• Kuchepa kwa plasma cholesterol chifukwa chopinga cha reductase komanso kuponderezedwa kwa cholesterol synthesis mu chiwindi.
• Munthawi yamankhwala, mankhwalawa amachepetsa kuchuluka kwa mafuta achilengedwe mwa anthu omwe ali ndi homozygous hypercholesterolemia (matenda obadwa nawo), matenda omwe sangathe kuthandizidwa ndimagulu ena a mankhwala a lipid-kuchepetsa.
• Mukamagwiritsa ntchito, kuchuluka kwa cholesterol yonse kumatsika ndi 25-45%, kuvulaza - mpaka 60%.
• Kuchuluka kwa alipoprotenin A kumawonjezeka chifukwa cha kapangidwe kake mafuta acids.
• Palibe matenda ndi mutagenic.

Ngakhale panali zotsatirapo zingapo zabwino, ma statin ali ndi zotsatira zoyipa zingapo, mwa zina zomwe zimakhala ndimmutu, matenda ammimba, myalgia, matupi awo onse, chizungulire, Hypesthesia, neuropathy, ndi zovuta zina zamagetsi.

Kutsutsa kwa kugwiritsa ntchito ma statins

Popeza mtengo wotsika mtengo wa chithandizo ndi njira yayitali, kutsutsa kwa ma statins kwanenedwa mobwerezabwereza ngati chithandizo cha cholesterol.

Chifukwa chake, kafukufuku yemwe adapangidwa ndi rosuvastine watsopano wa statin adawonetsa kuti kuwonjezereka kwa mankhwalawo kumakhudzidwa ndikuwonetsedwa pafupipafupi kwa zovuta.

Ngakhale izi, mankhwala osokoneza bongo a statin ndi omwe akutsogolera padziko lonse lapansi. Pakadali pano, kugulitsa atorvastatin ndi akaunti ya simvastatin osachepera 70% ya malonda athunthu a mankhwala a lipid otsitsa.

Mutha kuthana ndi zovuta zingapo mutatenga ma statins mutatenga coenzyme Q10. Amatengedwa pa 200 mg patsiku, ndipo odwala omwe ali ndi makilogalamu oposa 100 ayenera kumwa 300 mg.

Mankhwala a Statin

Tatha kuunikiranso zambiri, tikukulimbikitsani kuti mudziwe mankhwala omwe gulu la statin limagwiritsidwa ntchito ngati mankhwala a cholesterol apamwamba:

• Simvastatin - imadziwikanso pansi pa mayina amalonda Arieskor, Simvakol, Simvor, Vasilip, Holvasim, etc.,
• Pravastatin,
• Lovastatin - wotchedwanso choletar kapena cardiostatin,
• Fluvastatin (Leskol),
• Atorvastatin (Lipoford, Ator, Atocor, Liptonorm, etc.),
• Rosuvastatin (Rosulip, Rosart, Acorta, Tevastor).

Sitikulimbikitsidwa kuti mutenge ma statins ngati pali cholesterol yokhayo, koma palibe atherosclerosis, komanso ngati zomwe zili mu protein ya C-yogwira m'magazi ndizochepera 1 mg / dl.

Dziwani kuti gululi limaphatikizapo mapiritsi abwino kwambiri a cholesterol.Mankhwala ena amathandizanso, koma amakhala ndi mwayi wowonjezereka.

Mwachitsanzo, lingalirani mankhwala ena omwe angagwiritsidwe ntchito ngati mankhwala omwe amachepetsa cholesterol.

Otsatira a bile acid

Mphamvu ya mankhwalawa imachitika chifukwa chomangidwa m'matumbo a bile acids, omwe pambuyo pake amachotsedwa mwanjira yachilengedwe. Mankhwalawa amalimbikitsanso kapangidwe ka bile acid kuchokera ku cholesterol m'chiwindi.

Zonsezi zikuwoneka motere: mankhwala atatuluka ku cholesterol ya gulu lomwe limayamwa, alowa m'matumbo, mawonekedwe osakwanira a bile acid, izi zimaphatikizapo kusowa kwa asidi m'thupi la munthu, chifukwa chiwindi chimayambira kuphatikizika kwama acid kuchokera ku cholesterol lomwe lili kale m'madzi am'magazi.

Chifukwa chake, kubwezeretsanso kumachitika, komwe kuwonongeka kwa mafuta acid ndikofunikira kuti mapangidwe a bile.

Mankhwala ochepetsa kwambiri cholesterol amatchedwa cholestipol ndi cholestyramine. Amapezeka mu mawonekedwe a ufa ndi mapiritsi, ndipo tsiku ndi tsiku mlingo umagawika pawiri-kawiri kuti ukhale wothandiza kwambiri.

Mankhwalawa ndi a gulu la ma anion-exchange resins, chifukwa chake amangogwira m'matumbo a lumen ndipo samamwetsa m'magazi.

Izi zikutanthauza kuti palibe mavuto oyipa omwe amachitika chifukwa chogwiritsa ntchito mankhwalawa, motero, chithandizo cha cholesterol chachikulu, malinga ndi akatswiri, iyenera kuyamba nawo.

Zotsatira zoyipa zimangokhala ndi kusokonezeka kwa dongosolo logaya chakudya. Zitha kupewedwa pogwiritsa ntchito mavitamini, kudya madzi ambiri ndi zakudya zomwe zimakhala ndi fiber.

Chithandizo chimayambitsa kutsika kwa kuchuluka kwa cholesterol yoyipa, pomwe kuchuluka kwa triglycerides sikuchepa.

Hypolipidemic mankhwala a magulu ena

Dziwani kuti mndandanda wa mankhwala a cholesterol akhoza kukhala akulu kwambiri - pali masauzande ambiri mayina azogulitsa omwe ali ofanana pazinthu zawo.

Chifukwa chake, tikupitilizabe kuganizira za mapiritsi a cholesterol abwino kwambiri osati ndi dzina lokha, komanso ndi ma pharmacological awo:

1. Probucol ndi mankhwala omwe ali ndi ntchito yomweyo. Pafupifupi mayina 9 ogulitsa malonda amadziwikanso pamsika. Chidacho chimathandizira kuthana ndi cholesterol yabwino komanso yoyipa, pomwe kuchuluka kwa triglycerides mukamatenge sikusintha. Kutalika kwa mankhwalawa ndiku kuyambira miyezi iwiri mpaka miyezi isanu ndi umodzi, mwina kuphatikiza ndi mankhwala ena kuti muchepetse LDL. Ndi osafunika kugwiritsa ntchito mankhwalawa panthawi yapakati komanso pamatenda a minofu ya mtima (ischemia, arrhythmia), ilibe zotsutsana zina. Mankhwalawa amalekeredwa bwino, koma zovuta zina za dyspeptic ndizotheka. Awa ndimapiritsi abwino kwambiri, otsika mtengo a cholesterol, mtengo wake omwe si oposa ruble 300.
2. Nicotinic acid ndi kukonzekera zochokera. Imachepetsa ndende ya LDL m'magazi, imayambitsa kuthamanga kwa fibrinolysis. Ndi imodzi mwazinthu zothandiza kwambiri kuwonjezera kuchuluka kwa cholesterol. Chithandizo ziyenera kuchitika ndi kuwonjezeka pang'onopang'ono mu Mlingo wa chinthu. Zilonda zam'mimba, nicotinic acid sikuyenera kugwiritsidwa ntchito, chifukwa imatha kukhumudwitsa mucosa. Chiwerengero chochepa cha zoyipa ndi Enduracin - mankhwala omwe nicotinic acid ndiye chinthu chachikulu chogwira ntchito. Kugwira kwake ntchito kumakhala kokwanira kwambiri, ndipo mavuto ake ndi osowa.
3. Phytoesterols. Kuti muchepetse mulingo wa LDL m'magazi, sikofunikira kuti mugwiritse ntchito mankhwala okhawo kuti muchepetse cholesterol - mutha kugwiritsa ntchito zinthu zomwe zili ndi stanols ndi sterols (nthawi zambiri zimakhala zowonjezera zakudya).Ngakhale kuti kugwiritsa ntchito mankhwalawa "mwamphamvu" pogwiritsa ntchito mankhwala osokoneza bongo a statin kapena fibrate kumathandizira kwambiri, chifukwa cha mayesero azachipatala a 150, zimatsimikiziridwa kuti ma phytoesterols amathandizira kuchepetsa cholesterol yoyipa m'thupi ndi 6-15%.

Dziwani kuti chithandizo chofananachi chikugwiritsidwa ntchito ku maiko aku Western - mutha kuphunzirapo mankhwala ena kuti muchepetse cholesterol yamagazi patsamba lovomerezeka la Mayo Clinic network azachipatala omwe ali ku USA.

Cascade Plasma Filtration

Odwala omwe samathandizidwa ndi zakudya, komanso mankhwala okhala ndi cholesterol yayikulu sapereka zotsatira, amapatsidwa kusefa kwa plasma. Iyi ndi njira yapadera yoyeretsera magazi yomwe yakhala ikugwiritsidwa ntchito ku maiko aku Western kwa zaka zopitilira 30.

Masiku ano, njira zofananira zamankhwala zimagwiritsidwa ntchito m'maiko, koma pokhapokha atalandira chithandizo chamankhwala chomwe cholesterol yotsika sichinapereke zotsatira.

Njirayi imatha kwa maola awiri ndipo imayamba motere: magazi a wodwalayo amadutsa mwa njira yapadera, yomwe imawagawa m'magulu a madzi am'magazi ndi maselo, omwe amalumikizana ndi thupi la munthu, ndipo plasma imatsukidwa pogwiritsa ntchito zida zapadera.

Njira iyi imakupatsani mwayi kuti muthane ndi cholesterol ngakhale mapangidwe a cholesterol asanachitike - izi zimakupatsani mwayi kuyeretsa onse magazi ndi minofu.

Mankhwala ochepetsa cholesterol komanso kuyeretsa magazi

Mankhwala omwe amachepetsa cholesterol ndikuyeretsa mitsempha yamagazi amatengedwa kuti aletse mapangidwe a atherosrance. Gwiritsani ntchito mankhwalawa ayenera kufotokozedwa ndi dokotala. Komanso kukonza zakudya kumachitika, ndikusinthanso zakudya zomwe zimagwiritsidwa ntchito. Njira zoterezi zimathandizira kuchepetsa ngozi ya matenda a mtima nthawi zingapo.

Chifukwa chiyani cholesterol ikukwera?

Kuwonjezeka kwa magazi kumatchedwa hypercholesterolemia. Zimachitika pazifukwa zambiri. Zotsogola:

1. Zakudya zoperewera. Kugwiritsa ntchito kwambiri zinthu zovulaza (nyama yamafuta, chakudya chofulumira), kuchuluka kwa chakudya chamafuta kwambiri kuposa zovuta.
2. Kunenepa kwambiri. Amayenda kuchokera koyamba.
3. Kulephera kuchita masewera olimbitsa thupi. Anachepetsa mphamvu zamagalimoto, kumangokhala.
4. Makamaka. Kukhalapo kwa achibale ndi cholesterol yayikulu.
5. Matenda osachiritsika komanso zizolowezi zoyipa. Izi ndi monga: matenda a chiwindi, impso, matenda am'mimba, kumwa kwambiri mowa, kusuta, kugwiritsa ntchito mankhwala osokoneza bongo.

Chiwopsezo chachikulu chimapangidwa mwa anthu omwe ali ndi mikhalidwe yambiri nthawi imodzi. Kunyalanyaza cholesterol yayikulu, chiwopsezo chokhala ndi matenda amtima chambiri chikuwonjezeka 2 times. Zotsatira zake, izi zimayambitsa kuwundana kwa magazi ndi kupunduka kwa magazi.

Mwa amuna, mapangidwe a zolengeza amapezeka nthawi zambiri kuposa akazi. Kuwerengera kumeneku kumachitika chifukwa cha mawonekedwe a thupi. Mwachitsanzo, khoma lam'mimba la chiwalo chofooka, muteteze mahomoni.

Gulu la mankhwala ochepetsa magazi m'thupi

Mu pharmacology yamankhwala, mankhwalawa amatchedwa lipid-kuchepetsa. Amatha kuchepetsa ndikuyeretsa zombo za LDL ndi VLDL, triglycerides, ndikuwonjezera kuchuluka kwa HDL. Zinthu zofunika kuyeretsa zimagawidwa m'magulu angapo:

1. Madera (Lovastatin, Simvastatin, Atorvastatin).
2. Ezetimibe. (Ezetrol, Lipobon).
3. Nicotinic (Niceritrol, Enduracin, Acipimox).
4. Amachokera ku fibroic acid kapena ma fiber. (Tricor, Lipantil, Clofibrate).
5. Anion-exchange resins (sequestrant of bile acids). (Guarem, Questran, Colestyramine).
6. Kukonzekera kwa LCD. (Omacor, Doppelherz, Omeganol Forte).

Ma Statins ndiomwe amachepetsa cholesterol yambiri. Ma FIBates ndi nicotinic acid mankhwala ndibwino ku VLD. Zowonjezera zimagawidwa pagulu logawanika.

Chiwopsezo chotenga atherosulinosis (kuyimitsidwa kwa lipids yoyipa m'khoma la chotengera) chikuwonjezeka ndi matenda ashuga, hypothyroidism, cholestasis syndrome.

Mankhwala abwino kwambiri ochepetsa cholesterol yamagazi

Ganizirani mndandanda wazida zomwe zimathandizira pochiritsa. Pamodzi ndi mankhwala, njira zachikhalidwe zimagwiritsidwa ntchito. Izi zimaphatikizapo kugwiritsa ntchito uchi tsiku lililonse, ndimu, ginger wodula pang'ono. Izi zimathandizira kuyeretsa ziwiya ndikuthandizira chithandizo choyenera.

Nthawi zambiri amagwiritsidwa ntchito Lovastatin, Simvastatin, Atorvastatin. Fananizani ndi mankhwala omwe amalepheretsa ntchito ya enzyme. Kupezeka kwa gulu la mankhwalawa, momwe mankhwalawo amathandizira matenda a mtima ndi matenda a mtima asintha kwambiri. Choyezera chotengera chikhala motere:

• chopinga cholesterol synthesis,
• kutsika kwa zomwe zili m'maselo a chiwindi,
• kuchuluka kwa zolandila zomwe zayambitsa kuthana kwa LDL ndi VLDL.

Zotsatira zake, kuchuluka kwa lipids zoyipa m'magazi kumatsika, ndipo kuchuluka kwa zabwino zimachuluka. Mphamvu ya mankhwala imayamba pakatha miyezi iwiri. Pachifukwa ichi, amatengedwa kuti akhale ndi moyo. Odwala amamwa mapiritsi kamodzi patsiku chakudya chamadzulo.

Sizoletsedwa kuyeretsa ziwiya ndi ma statins pa nthawi ya pakati, poyamwitsa komanso munthawi yogwira matenda a chiwindi.

Mankhwala amagulitsa pansi pa dzina la Ezetrol, Lipobon. Ndi m'gulu la opanga mankhwala omwe amathandiza kuchepa magazi m'thupi. Ili ndi zinthu zingapo poyeretsa:

• muchepetse kuyamwa
• letsa transporter yomwe imayendetsa lipid.

Zimawonjezeredwa ku chithandizo chamankhwala komanso mukamatenga ma statins. Zosagwiritsidwa ntchito mwa ana ochepera zaka 10, omwe ali ndi chiwindi matenda. Zotsatira zosafunikira: mutu, nseru, kutsegula m'mimba, kudzimbidwa.

Kukonzekera kwa Nicotinic Acid

Mitsempha yamagulu a mavitamini imayeretsanso magazi. Zili pagulu la B3. Muchipatala mungapeze mapiritsi a nicotinic acid omwe, Niceritrol, Enduracin, Acipimox. Kutsika kwa cholesterol kumachitika mukatenga ndende yomwe imaposa zomwe zimafunikira tsiku lililonse. Makina ochitira zinthu ndi awa:

• kuletsa kapangidwe ka VLDL m'chiwindi,
• kutsika kwamasamba amafuta am'mimba momwe amachokera cholesterol yoyipa.
• kumawonjezera kuchuluka kwa HDL.

Kudya sizimakhudza mayamwidwe. Gawani ngati chida chowonjezerapo pakugwiritsa ntchito ma statins kapena motsutsana ndi maziko a tsankho.

Contraindication: kuthamanga kwa magazi, m'mimba ndi m'mimba zilonda zam'mimba, matenda a shuga, kutenga pakati, kuyamwa.

Kukonzekera Kwamafuta

Amagwiritsidwa ntchito kutsitsa triglycerides. Izi zikuphatikizapo Omacor, Doppelherz, Omeganol Forte. Amawonjezera ma statins kapena ma fiber. Chidule:

• zotumphukira za eicosapentaenoic ndi deoxyhexanoic acid,
• chepetsani kuchuluka kwa lipids zoyipa.

Sikugwiritsidwa ntchito poyeretsa mitsempha yamagazi ndi zotupa, matenda a chiwindi komanso nthawi yapakati.

Osamagwiritsira ntchito mankhwala osokoneza bongo, ndi chakudya chamagulu othandizira. Zombo zoyeretsa, zimagwiritsidwa ntchito pokhapokha ngati mankhwala. Muli ma flavonoids omwe amakhudza metabolidi ya lipid ndikuthandizira cholesterol yotsika. Ntchito yoyeretsa:

• Atheroclephitis,
• Vita Taurin,
• Lecithin Granules.

Zokonzekera zina zimakhala ndi zomera, bifidobacteria.

Kudziyang'anira nokha sikulimbikitsidwa. Osamagwiritsa ntchito mankhwala, chifukwa momwe zimagwiritsidwira ntchito zimatha kusiyanasiyana ndizofunikira.

Kukonzekera kutsitsa cholesterol ndi kuyeretsa kwamitsempha yamagazi Lumikizanani

Fibates: mndandanda wa mankhwala, magwiridwe antchito, kusiyana ndi ma statins

Fibates - gulu la mankhwala omwe amachepetsa kuchuluka kwa triglycerides, otsika kwambiri, otsika kwambiri a lipoproteins (LDL, VLDL), cholesterol, amawonjezera zomwe zili ndi kuchuluka kwa milingo ya lipoproteins (HDL). Asanapangidwe, ma statin anali ogwiritsidwa ntchito kwambiri pochiza matenda a atherosulinosis. Masiku ano, mankhwalawa amagwiritsidwa ntchito pochiza odwala omwe ali ndi triglycerides kwambiri komanso otsika HDL.

Mankhwala oyamba a gululi anali clofibrate, omwe amagwiritsidwa ntchito kwambiri mu 60-70s. Kenako adasinthidwa ndi mankhwala am'badwo wachiwiri ndi wachitatu: fenofibrate, bezafibrat, ciprofibrate, gemfibrozil.

Kodi fibrate - mfundo yofunika kuchita

Fibates ndi mankhwala a hypolipidemic - mankhwala omwe amachepetsa magawo a lipids, lipid-like zinthu (cholesterol). Mankhwalawa amachokera ku fenofibroic acid, omwe adawapatsa dzinali. Limagwirira ntchito ya fibrate amatengera kuthekera kwawo:

• onjezerani zochitika za lipotrotein lipase ya enzyme, yomwe imayambitsa kuwonongeka kwa ma chylomicrons, VLDL yokhala ndi triglycerides,
• onjezani kuchuluka kwa zolandila zomwe zimagwira ndi kukonza LDL,
• onjezerani secretion wa cholesterol ndi bile, muchepetse kaphatikizidwe ka sterol,
• kukondoweza kwa kapangidwe ka apolipoproteins AI, III.

Mlingo wa triglycerides (mafuta osalowerera), VLDL, LDL, cholesterol amachepetsa, ndipo HDL imachuluka. Kusintha kwa kuchuluka kwa mafuta a metabolism kumakhala ndi zotsatira zabwino popewa kupitilira kwa atherosulinosis, komanso kukula kwa zovuta zake - matenda a mtima, kupindika kwa myocardial, aneurysm yammimba, ndi stroko.

Mankhwala amachepetsa:

• chakudya dyslipidemia,
• fibrinogen (mawonekedwe a thrombus),
• uric acid
• GGT, alkaline phosphatase ntchito,
• amachepetsa magazi.

Mitengo imayamwa bwino kuchokera m'mimba. Mosiyana ndi ma statin, thupi limapukusidwa makamaka ndi impso.

Mndandanda wazinthu zabwino kwambiri

Ma nyuzi amakono amayimiridwa ndi mibadwo itatu:

• 1 - kusinthana,
• 2 - gemfibrozil, bezafibrat,
• 3 - fenofibrate, ciprofibrate.

Kamodzi pa nthawi, zofala zotchuka nthawi zambiri sizigwiritsidwa ntchito. Zinatsimikiziridwa kuti mankhwalawa amathandizira kukulitsa zotupa zoyipa zam'mimba, mitundu ina ya oncology yam'mimba. Mtundu wothandiza kwambiri wa fibrate umadziwika kuti ndi ma micronanules. Amalumikizidwa bwino ndi thupi, imathandiza kwambiri.

Zotsatira zoyipa zam'badwo waposachedwa wa fibrate

Zotsatira zoyipa za fibrate nthawi zambiri zimakhala zochepa, zazifupi. Nthawi zambiri, odwala amadandaula zam'mimba, mseru, mutu, zidzolo. Zizindikiro zotere zimapezeka mu 5-10% ya odwala.

Woyimira aliyense wa gulu la fibrate ali ndi mndandanda wake wazotsatira zoyipa. Koma pali zovuta zingapo zomwe ndizodziwika ndimankhwala ambiri:

• kusintha kwa kapangidwe ka bile, komwe kumawonjezera chiopsezo chokhala ndi matenda a ndulu (mankhwala a mibadwo 1-2)
• chiwindi
• chisangalalo
• kapamba
• kulephera kwa aimpso
• kudziwa kuwala
• arrhythmias
• kutupa kwa minofu
• myopathies
• khalokuz
• kufooka wamba
• utachepa potency (mawonekedwe a cyclofibrate).

Zotsatira zoyipa za mankhwala am'badwo watsopano

Ngakhale mankhwala akupita kukathetsa kwathunthu mavuto obwera chifukwa cha kumwa mankhwala, mpaka pano, Fenofebrat ndi woimira m'badwo wachitatu wa gulu la fibrate, adakali ndi zovuta zina, zomwe zimawonedwa pafupifupi 10% ya odwala. Chimodzi mwazomwe zimachitika ndizosasangalatsa pamimba, kumva kutopetsedwa m'mimba, komanso kugaya chakudya.

Zotsatira za zoyipa pambuyo pakutenga ma fupa a mibadwo ya III.

Pafupifupi 1 mwa 100 odwala adzakumana ndi mavuto monga:

• kufooka kwa minofu
• mutu
• nseru
• kuchepa kwa hemoglobin m'magazi,
• pang'ono totuwa khungu.

Osowa kwambiri muzochitika zachipatala pakhala pali milandu yotsuka tsitsi, kukula kwa chiwindi. Pankhaniyi, mankhwalawa amayimitsidwa nthawi yomweyo.

Kuphatikiza pa fiber, palinso njira zina. Owerenga amalimbikitsa mankhwala achilengedwe, omwe, kuphatikizapo zakudya komanso ntchito, amachepetsa kwambiri mafuta m'thupi pambuyo masabata 3-4. Maganizo a madotolo >>

Fibates kapena statins - ndibwino?

Statins ndi lipid-kuchepetsa mankhwala opangidwa kuti athetse matenda a lipid kapena, mopepuka, kuti achepetse kuchuluka kwa "cholesterol yoyipa" ndikuwonjezera gawo la "cholesterol yabwino". Ngakhale zofanana ndi izi, mfundo ya ma statins ndi yosiyana ndi ma fiber.

Statins imagwira maselo a chiwindi, kutseka ma michere omwe akukhudzidwa ndi kapangidwe ka cholesterol, chifukwa chake kupanga kwake kumachepetsedwa kwambiri. Statin imalimbikitsanso mitsempha ya magazi, imapangitsa kuti ikhale yodalirika, komanso kuchepetsa mwayi wokhala ndi zigawo za atherogenic lipid pamakoma.

Kafukufuku ku mayunivesite aku London adawonetsa kuti kuwonjezera pa zovuta zonse zomwe zafotokozedwa pamwambapa, ma statins amasintha kapangidwe kake ndi kagwidwe ka mtima.

Anthu omwe amamwa mankhwalawa pafupipafupi samakhala ndi mwayi wokuwona kuchuluka kwa minofu ya mtima, komwe ndi chizindikiro cha kufooka kwa minofu.

Mpaka pano, kuti muchepetse cholesterol, ma statins a m'badwo wa 3 ndi 4 amagwiritsidwa ntchito: Atorvastatin ndi Rosuvastatin.

Kusiyana kwakukulu pakati pa ma fibrate ndi ma statins potengera zakale pamlingo wa triglycerides.

Kugwiritsa ntchito ma statins, komanso mankhwala ena omwe alipo masiku ano, sikungalepheretse kwathunthu chitukuko cha atherosulinosis ndi zotsatira zake, ndipo pakubwera mphindi pamene mwayi wa ma statins utatha, ndikusintha kowonjezereka kwa ma doses ndi zinthu zomwe sizikuyenda kumabweretsa zotsatira zabwino zamankhwala.

Malinga ndi machitidwe azachipatala, kuthekera kwama statins kumatha mphamvu ya cholesterol ya 7.4 mmol / l kapena kuposa. Pazowonetsa pamwamba pamtunda uno, madokotala mosakayikira amapereka mankhwala angapo, nthawi zambiri ma statin amagwiritsidwa ntchito molumikizana ndi ma fibrate. Chifukwa chake, kunena kuti ndi mankhwala ati omwe ali bwino sikutheka.

Kodi mukuganizabe kuti kuthana ndi cholesterol yamagazi ndikosatheka?

Poona kuti mukuwerenga izi tsopano - vuto la cholesterol yayikulu mwina likukuvutitsani kwakanthawi. Koma izi sizolankhula nthabwala ayi: kupatuka kotereku kumakulitsa magazi ndipo ngati sichingachitike, kumatha kutha kwambiri.

Koma ndikofunikira kumvetsetsa kuti ndikofunikira kusamalira osati zotsatira zake mwanjira yakukakamizidwa kapena kuiwalika, koma choyambitsa.

Mwina muyenera kuzolowera zida zonse pamsika, osati kungotsatsa? Inde, nthawi zambiri, mukamagwiritsa ntchito mankhwala opangira mankhwala omwe ali ndi zotsatira zoyipa, zimachitika zomwe zimadziwika kuti "chimodzi chimagwira, zina zolumala". M'modzi mwa mapulogalamu ake, a Elena Malysheva adakhudza mutu wa cholesterol yayikulu ndipo adalankhula za mankhwala omwe amapangidwa kuchokera kuzomera zachilengedwe ...

Werengani nkhani ya Elena >>> ...

Kutsitsa cholesterol ndi mankhwala

Kuchulukitsa kuchuluka kwa mafuta m'thupi kumakhala kowopsa kwambiri. Vutoli ndilofala kwambiri masiku ano ndipo, ngakhale kuti zifukwa zazikulu zomwe zimaphunzitsidwa ndi madokotala, sizotheka nthawi zonse kuchitapo kanthu kupewa matenda.

Nthawi zambiri odwala amagwiritsa ntchito njira zosiyanasiyana kuthana ndi vuto lofananalo: kulowetsedwa kwa zitsamba zamankhwala ndi mapiritsi. Muzochitika zapamwamba, pamene vuto la mowa wamafuta mthupi lili m'njira yapadera, opaleshoni imachitidwa.

Komabe, mapiritsi osankhidwa bwino panthawi yoyenera cholesterol amathandiza kuchepetsa chiopsezo cha kuwonetsa zovuta.

Momwe mungachepetse cholesterol yoyipa

Zinthu zambiri zimatha kuchotsa lipoprotein yotsika m'thupi ndikukulitsa kuchuluka kwa mowa wofunikira. Kuchuluka kwa cholesterol yoyipa ndiyowopsa.

Poyerekeza ndi kuphwanya koteroko, chiopsezo chotenga matenda am'mitima ya mtima ndi magazi mwa munthu chimawonetsedwa. Popeza matenda oterewa amatenga miyoyo ya anthu ambiri chaka chilichonse, ndikofunikira kudziwa njira zoyambira zothanirana ndi vutoli.

Piritsi iyenera kusankhidwa ndi dokotala kuti muchepetse cholesterol yamagazi. Pambuyo pa matenda ena. Kuphatikiza apo, katswiriyo ayenera kuyang'anitsitsa momwe amasinthire komanso ngati pakufunika kutero, asinthe njira yakuchiritsira.

Kodi ndimankhwala ati omwe amagwiritsidwa ntchito kuphatikiza zizindikiro zofunika ndipo zimakhudza bwanji thupi la munthu? Mayankho a mafunso amenewa afotokozedwa m'nkhaniyi.

Zambiri

Mapiritsi a cholesterol okwera m'magazi amasankhidwa ndi dokotala aliyense payekha kwa wodwala aliyense.

Yang'anani! Katswiri yekha ndi amene angalimbikitse wodwala chida chomwe chimapereka cholozera cha mafuta ammadzi komanso matenda a thanzi. Kusankha kwakanokha kwamankhwala sikungapangitse zotsatira zomwe zikuyembekezeredwa, wodwalayo angakumana ndi zovuta zingapo pakugwiritsa ntchito.

Chithandizo chamakono chimasiyanitsa magulu angapo a mankhwala omwe amapangidwa kuti akhazikitse zizindikiro:

• mafupa
• ma statins
• zigawo zomwe zimakulitsa katulutsidwe ka ma asidi a bile,
• zotumphukira za niacin ndi gawo lokha,
• zamagulu ophatikizira.

Zinthu zonsezi zimasiyana machitidwe amomwe amachititsa thupi la munthu. Zinthu zomwe zimagwira ntchito zosiyanasiyana, mosiyanitsa zimakhudza thupi.

FFA - sequestrants za bile acid

Mukamaganizira mapiritsi a cholesterol yayikulu m'magazi, munthu sangangotchulapo zinthu monga sequestrants za bile acid. Zinthu zoterezi zitha kutengedwa zokha kapena kugwiritsidwa ntchito ngati mankhwala osokoneza bongo.

Yang'anani! Mfundo zoyeserera za bile acid sequestrants zimakhazikitsidwa padera pa kubwezeretsa kolesterol.

Poyerekeza ndi kagwiritsidwe ntchito ka zinthu zoterezi, zosintha zotsatirazi zimachitika: Mafuta akumwa amachotsedwa m'thupi popanda kulowa m'magazi. Kutengera ndi chidziwitso ichi, titha kudziwa kuti lipoproteins yotsika kwambiri imachoka mofulumira m'thupi popanda kulowa m'magazi.

Chofunikira kwambiri cha mankhwalawa ndikuti ali otetezeka kwathunthu. Kunyowa m'magazi sikumachitika, zomwe zimapangitsa kupereka njira zotere kwa anthu omwe ali pachiopsezo: azimayi oyembekezera, ana ndi odwala omwe ali ndi mavuto osiyanasiyana pogwira ntchito kwa thupi.

Ngakhale atetezedwe kotere, mavuto obwera chifukwa chakumwa amatha kukhalabe. Izi zikuphatikiza:

• kukhumudwa kwakanthawi kochepa,
• kuwonekera kwa kutentha
• kusanza ndi kusanza.

Zizindikiro zolembedwa nthawi zambiri zimakhala zachilengedwe ndipo zimangowonekera kwa nthawi yoyamba yokha masiku atatu kuyambira nthawi yolowa. Chithandizo cha Syndrome nthawi zambiri sichofunikira, koma zizindikiritso ziyenera kudziwitsidwa kwa dokotala. Ngati wodwala atatha masiku 5-7, matendawa a cholesterol okwanira m'magazi amayimitsidwa ndipo amasankhidwa m'malo mwake.

Mapiritsi ochepetsa magazi a cholesterol amasankhidwa payekha ndi dokotala, ataphunzira zambiri zamatenda a wodwala wina. Ndikofunika kukumbukira kufunika kochezera pafupipafupi kwa katswiri, izi zitsimikiza kuwunika kwathunthu komanso kusintha kwakanthawi kwa njira zochizira ngati pakufunika.

Sizotheka kukwaniritsa zotsatira zanu zokha, osayanjananso ndi dokotala, chifukwa odwala ayenera kukumbukira kuti ndizowopsa kuchitira nokha.