Momwe mungagwiritsire ntchito mankhwala Glyurenorm?

Mankhwala Glurenorm ndi wothandizira pakamwa wa hypoglycemic, womwe ndi wochokera ku m'badwo wachiwiri. Glurenorm imathandizira kubisalira kwa insulin ya insulin mwa pancreatic β-cell, kumakulitsa kugwiritsidwa ntchito kwa glucose, linalake ndipo tikuletsa lipolysis.
Glurenorm imachepetsa kukana kwa insulin mu chiwindi ndi ma adipose minofu yowonjezera kuchuluka kwa insulin zolandilira komanso njira zolimbikitsira za post-receptor chifukwa cha zochita za insulin. Chofunikira pakuchita kwa hypoglycemic kwa Glyurenorm ndi kukhalapo kwa insulin.
Mphamvu yochepetsera shuga m'magazi imayamba mphindi 60-90 patatha pakamwa ndikufikira pakapita maola atatu pambuyo poti ituluke.
Kutalika kwa zotsatira za hypoglycemic ya Glurenorm ndi maola 8-10. Chifukwa chake, Glurenorm imadziwika kuti ndi mankhwala osakhalitsa.
Kugwiritsa ntchito sulfonylureas, omwe ndi mankhwala osokoneza bongo kwakanthawi, amalimbikitsidwa pochiza odwala omwe ali pachiwopsezo cha hypoglycemia, mwachitsanzo, odwala okalamba komanso odwala omwe amalephera aimpso.
Popeza kuti aimpso amachotsedwa kwa Glyurenorm, mankhwalawa amatha kuperekedwa makamaka kwa odwala omwe amalephera kupweteka aimpso kapena matenda a shuga.
Kugwiritsa ntchito bwino komanso chitetezo cha Glyurenorm kwa odwala omwe ali ndi matenda osokoneza bongo kwatsimikiziridwa, zomwe zikuwonetsedwa pakukonzekera ndi sulfonylurea kukonzekera komwe kumayenderana ndi matenda a chiwindi.
Pharmacokinetics Patatha maola 2-3 atatha kumwa 30 mg wa Glurenorm, kuchuluka kwambiri kwa plasma kumafikiridwa (500-700 ng / ml), kutsatiridwa ndi kutsika kwapafupipafupi kwa maola 1 / 2-1. mankhwala.
Glurenorm imagwira ntchito limodzi ndi mapuloteni a plasma (99%).
Glurenorm imapangidwa kotheratu, makamaka ndi hydroxylation ndi demethylation. Zambiri mwa metabolites zimapukusidwa kudzera mu biliary system yokhala ndi ndowe. Kachigawo kochepa chabe ka metabolites kamatuluka ndi impso. 5% yokha ya kuchuluka kwa mapiritsi imapezeka mu mkodzo. Ngakhale Mlingo wobwereza wa Glyrenorm utagwiritsidwa ntchito, kupweteka kwa impso kumakhalabe kochepa.
Kuphatikiza apo, ndikukhazikika kwa Glyrenorm kwa odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto la impso, palibe kusintha komwe kunapezeka komwe kunapezeka. Palibe chiopsezo chowerengera zinthu kapena ma metabolites ake.
Magazi metabolites ndi a pharmacodynamically osagwira ndipo samakhudza kuchuluka kwa shuga m'magazi.
Kuyesa kwa pharmacological komwe kumachitika pa mbewa ndi mbewa kwawonetsa kuti Glyrenorm ndi metabolites ake sawoloka BBB kapena placental barriers.

Kugwiritsa ntchito mankhwala Glyurenorm

Chithandizo choyambirira
Nthawi zambiri, muyeso woyamba wa Glenrenorm ndi piritsi 1/2 (15 mg). Amatengedwa nthawi ya chakudya cham'mawa. Ndi kusakwanira, mlingo umatha kuwonjezeka pang'onopang'ono. Malinga ngati palibe mapiritsi 2 (60 mg) omwe adapangidwira, mlingo wa tsiku ndi tsiku wa Glyurenorm ungatengedwe kamodzi pakudya kadzutsa. Komabe, mukamagwiritsidwa ntchito mu Mlingo wapamwamba, kuwongolera bwino kwambiri kumaperekedwa ndi 2-3 kawiri pa tsiku. Pankhaniyi, mlingo woyenera uyenera kumwedwa nthawi ya chakudya cham'mawa. Mapiritsi a Glenrenorm ayenera kumwedwa kumayambiriro kwa chakudya. Dziwani kuti kuwonjezera kuchuluka kwa mapiritsi 4 (120 mg) patsiku nthawi zambiri sikuti kumabweretsa chiwongola dzanja china.
Mukamayikanso wothandizira wina wamkamwa pogwiritsa ntchito makina ofanana
Mlingo woyambirira umatsimikiziridwa kutengera njira ya matendawa panthawi ya mankhwala. Mukasankha wina wogwirizira wothandizila ndi Glurenorm, muyenera kukumbukira kuti piritsi limodzi la Glurenorm ndi lofanana ndi 1000 mg ya tolbutamide.
Kuphatikiza mankhwala
Ngati monotherapy yokhala ndi Glurenorm sichimapereka chiwonetsero chokwanira cha kuchuluka kwa shuga m'magazi, kuwonjezereka kwa Biguanide kuyenera kuganiziridwanso.
Kutalika kwa njira ya mankhwalawa kutengera mtundu wa matendawa komanso kuthandizira kwake.

Contraindication kugwiritsa ntchito mankhwala Glurenorm

Mtundu wotengera insulin I shuga, kupunduka, matenda ashuga komanso precomatosis, chifuwa chachikulu cha shuga Kukonzekera kwa sulfonylurea.

Zotsatira zoyipa za mankhwala Glenrenorm

Monga lamulo, Glurenorm imalekeredwa bwino ndi odwala, koma nthawi zina hypoglycemic zimachitika, nseru, kusanza, kudzimbidwa, kuchepa kwam'mimba, kusowa chilimbikitso: kuyabwa, kupweteka, mutu, chizungulire, kusokonezeka kwa malo okhala, thrombocytopenia kumatha kuchitika.
Nthawi zina, intrahepatic cholestasis, urticaria, Stevens-Johnson syndrome, leukopenia, agranulocytosis angayambe.

Malangizo apadera ogwiritsira ntchito mankhwala Glurenorm

Nthawi ya pakati ndi kuyamwa. Kafukufuku wamagwiritsidwe ntchito a Glyurenorm pa nthawi yoyembekezera komanso mkaka wa m'mawere sanachitike. Chifukwa chake, kugwiritsa ntchito Glurenorm kuyenera kupewedwa panthawiyi. Ngati mimba yakhazikitsidwa, ndikofunikira kusiya kumwa Glyurenorm posachedwa.
Pochiza matenda a shuga, kuyang'aniridwa kawirikawiri kuchipatala ndikofunikira. Kusamalidwa kwapadera kuyenera kuthandizidwa pakusankhidwa kwa mankhwala kapena kumwa mankhwala.
Ngakhale ndi 5% yokha ya Glurenorm yomwe imachotsedwapo ndi impso ndipo nthawi zambiri imavomerezedwa bwino kwa odwala omwe ali ndi matenda a impso, chithandizo cha odwala omwe ali ndi vuto laimpso liyenera kuchitika moyang'aniridwa ndi achipatala.
Odwala omwe ali ndi matenda ashuga amakonda kuchita matenda a mtima. Izi zitha kuchepetsedwa pokhapokha kutsatira zakudya zomwe dokotala watipatsa. Kugwiritsa ntchito mankhwala othandizira odwala matenda ashuga sayenera kuthandizira kudya kwina komwe kumakupatsani mwayi wowongolera thupi ndipo kumalimbikitsidwa ngakhale mutagwiritsa ntchito mankhwala a hypoglycemic. Onse othandizira odwala matenda am'mimba omwe amadya zakudya zosakhazikika kapena kuphwanya mlingo wovomerezeka angayambitse kuchepa kwakukulu kwa shuga m'magazi. Kugwiritsa ntchito shuga, maswiti, kapena zakumwa za shuga kumathandizanso kupewa matenda asanakwane.
Kukopa pa kuyendetsa magalimoto ndikugwira ntchito ndi zina.Odwala ayenera kuchenjezedwa za kutsatira njira zopewera hypoglycemia poyendetsa. Izi ndizofunikira kwambiri kwa iwo omwe alibe zizindikiro za hypoglycemia kapena omwe amazindikira pafupipafupi gawo la hypoglycemia. Kuyenera koyendetsa kuyenera kuonedwa molingana ndi zochitika izi.

Kuchita ndi mankhwala Glurenorm

Kuyanjana komwe kungachitike ndi mankhwala omwe amakhudza kagayidwe ka glucose kuyenera kukumbukiridwa.
Mankhwala omwe amatha kupititsa patsogolo zotsatira za hypoglycemic za Glurenorm: NSAIDs, Mao inhibitors, oxytetracyclines, ACE inhibitors, clofibrate, cyclophosphamides ndi zotumphukira zawo, mankhwala a sulfonamides ndi mankhwala ena omwe amalepheretsa excretion, mankhwala ena a antidiabetes.
Mankhwala omwe amatha kupititsa patsogolo zotsatira za hypoglycemic za Glurenorm: β-adrenergic receptor blockers, ena a sympatholytics (mwachitsanzo, clonidine), reserpine, guanethidine. Zinthu izi zitha kugwiranso ntchito zizindikiro za hypoglycemia.
Mankhwala omwe amatha kuchepetsa kuchuluka kwa hypoglycemic kwa Glurenorm: GCS, kulera kwa steroid, sympathomimetics, mahomoni a chithokomiro, glucagon, diuretics (mtundu wa thiazide kapena loop diuretics), diazoxide, phenothiazine, nicotinic acid.
Ma Barbiturates, rifampicin, phenytoin ndi zinthu zina zofananira zimachepetsa kuopsa kwa zotsatira za hypoglycemic za Glyrenorm polimbikitsa michere ya chiwindi.
Kutsika kapena kuwonjezeka kwa zovuta za hypoglycemic ya Glurenorm kumadziwika ndi kugwiritsa ntchito pamodzi ndi H2 receptor antagonists (cimetidine, ranitidine) ndi mowa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mtundu wa Glyurenorm ndi mapiritsi: ozungulira, osalala, oyera, okhala ndi mbali zokutidwa, mbali ina pali zolemba za kampani, mbali inayo pali zoopsa, mbali zonse ziwiri pali zolemba "57C" (ma PC 10. Matuza 12 mu paketi okhala ndi makatoni).

Yogwira pophika: glycidone, piritsi limodzi - 30 mg.

Zowonjezera: sungunuka ndimanga wowuma, wowuma chimanga wowuma, magnesium stearate, lactose monohydrate.

Mankhwala

Glycvidone imawonjezera kaphatikizidwe ka insulin mwa kuyambitsa njira yolumikizira shuga kuti ipange chinthuchi. Kuyesa kwa zinyama kumatsimikizira kuti mankhwalawa amachepetsa kukana kwa insulin mu minofu ya adipose ndi minyewa ya chiwindi pakukulitsa kuyanjana kwa insulin receptors, komanso kulimbikitsa njira ya post-receptor yoyambitsidwa ndi insulin. Hypoglycemic effect imayamba maola 1 mpaka 1.5 pambuyo pakamwa. Kuchuluka kwake amalembedwa patatha maola awiri pambuyo pa utsogoleri ndipo kumatenga maola 8-10. Glycvidone ndi sulfonylurea yochokera kwa kanthawi kochepa, yomwe imayambitsa kugwiritsidwa ntchito kwa odwala omwe ali ndi matenda a shuga 2 omwe ali ndi chiopsezo chachikulu cha hypoglycemia, mwachitsanzo, mwa odwala okalamba kapena odwala omwe ali ndi vuto la impso.

Popeza glycidone amathandizidwa kudzera mu impso yaying'ono, mankhwalawa amatha kuperekedwa kwa odwala omwe ali ndi matenda ashuga nephropathy komanso aimpso ntchito. Pali umboni kuti kutenga Glenrenorm mwa odwala omwe ali ndi matenda a shuga 2, omwe akudwala matenda amchiwindi, ndi othandiza komanso ndi otetezeka. Komabe, chimbudzi cha zinthu zomwe zimagwira ntchito mwa odwala sichimalephera. Pankhaniyi, kukhazikitsidwa kwa glycidone kwa odwala omwe ali ndi matenda osokoneza bongo osakanikirana ndi zovuta kwambiri kwa hepatic sikulimbikitsidwa.

Zotsatira za kafukufuku wazachipatala zimatsimikizira kuti kugwiritsa ntchito Glyurenorm kwa miyezi 18 ndi 30 sikuyambitsa kuchuluka kwa thupi, ndipo nthawi zina pamakhala kuchepa kwambiri kwa thupi ndi makilogalamu 1-2. Kafukufuku woyerekeza omwe ena omwe amapezeka mu sulfonylurea anaphunziridwa amatsimikizira kusowa kwakukulu kwa kusintha kwa thupi mwa odwala omwe akutenga glycidone.

Pharmacokinetics

Ndi kumeza kamodzi kwa glycidone pa mlingo wa 15 kapena 30 mg, chinthucho chimatengedwa kuchokera m'matumbo oyenda ndi kuthamanga kwambiri ndipo pafupifupi kwathunthu (80-95%). Kuchuluka kwa kuchuluka kwa madzi a m'magazi m'magazi a 0,65 μg / ml (kumasiyana kuchokera pa 0.12 mpaka 2.14 μg / ml) ndikufikiridwa pafupifupi maola 2 mphindi 15 (kusinthasintha kosiyanasiyana kwa 1.25-4.75 ndikotheka maola). Dera lomwe lili pansi pa ndende nthawi yayikulu (AUC) ndi 5.1 μg × h / ml (kusinthasintha pakati pa 1.5 ndi 10,1 μg × h / ml ndikotheka).

Palibe kusiyana mu magawo a pharmacokinetic pakati pa anthu athanzi ndi odwala omwe ali ndi matenda osokoneza bongo.

Glycvidone amadziwika ndi mgwirizano wapamwamba wa mapuloteni a plasma ochulukirapo 99%. Zambiri pamaluso azinthu kapena ma metabolites ake kudzera mu ubongo-wamagazi ndi zotchingira za placental zikusowa. Palibe umboni womwe wapezeka kuti glycidone atha kukhalapo mkaka wa m'mawere.

Glycvidone imapukusidwa kwathunthu m'chiwindi, makamaka kudzera mu demethylation ndi hydroxylation. Glycvidone metabolites ndiwothandizika pamankhwala, kapena kuwonetsa zochitika pang'ono podziyerekeza ndi pawiri la kholo.

Glycvidone metabolites amuchotsa makamaka ndi ndowe, ndipo ochepa mwaiwo ndi omwe amaponyedwa mkodzo. Zotsatira zakufufuza zikuwonetsa kuti pambuyo pakukonzekera kwamlomo, pafupifupi 99% ya glycidone imatuluka kudzera m'matumbo. Pafupifupi 5% (mu mawonekedwe a metabolites) ya kumwa yomwe adatenga imatuluka kudzera mu impso, ndipo njirayi siyodalira mlingo ndipo sizodalira njira yoyendetsera Glyurenorm. Ngakhale kugwiritsa ntchito mankhwalawa pafupipafupi, imatulutsidwa mu mkodzo mosakhazikika kwambiri.

Kutha kwa theka-moyo ndi maora a 1.2 (kuchuluka kwa kusinthika ndi maola 0,4-3), ndipo kutha kwa theka-moyo ndi pafupifupi maola 8 (mtengo ukhoza kusiyana ndi maola 5.7 mpaka 9.4).

Odwala aukalamba ndi zaka zapakati, magawo a pharmacological ndi ofanana. Odwala aimpso ndi chiwindi dysfunctions, kuchuluka kwa glycvidone amachotsa ndowe. Pali umboni kuti kagayidwe kake kogwira mankhwalawa kamakhala kosasinthika kwa odwala omwe ali ndi vuto la chiwindi. Popeza glycidone amathandizidwa kudzera mu impso yaying'ono, palibe kukonzekera kwa mankhwalawa odwala omwe ali ndi vuto laimpso.

Malangizo ogwiritsira ntchito Glyurenorm: njira ndi mlingo

Glurenorm imatengedwa pakamwa malinga ndi zomwe dokotala akutsimikiza zokhudzana ndi kumwa komanso zakudya.

Kumayambiriro kwa zamankhwala, monga lamulo, mapiritsi a are amayikidwa pakudya cham'mawa (kumayambiriro kwa chakudya). Ngati palibe kusintha komwe kumadziwika, mlingo umawonjezeka.

Ngati mlingo wa tsiku ndi tsiku upitirire mapiritsi 2, ayenera kumwedwa pakumwa kamodzi m'mawa. Ngati ichulukitsa, ndikofunikira kugawanitsa ndi Mlingo 2-3, koma tengani gawo lalikulu kwambiri m'mawa m'mawa.

Mulingo wovomerezeka tsiku lililonse ndi mapiritsi 4. Kuchulukitsa mlingo wa mapiritsi opitilira 4 sikungathandize, chifukwa sizitsogolera pakuwonjezeka.

Osadumpha chakudya mutatha kumwa Glyurenorm ndikusiya mankhwala osafunsa dokotala.

Popereka mankhwala mankhwala oposa 75 mg (mapiritsi a 2,5), odwala omwe ali ndi vuto la chiwindi amafunikira kuwunika momwe zinthu zilili.

Ngati vuto losakwanira lachipatala pa monotherapy ndi Glyrenorm, mankhwala othandizira osakanikirana ndi metformin amatha kuikidwa.

Zotsatira zoyipa

Hematopoietic dongosolo: leukopenia, thrombocytopenia, agranulocytosis,
Machitidwe amanjenje: kugona, vertigo, paresthesia, mutu, kutopa,
Mtima wamtima: extrasystole, hypotension, angina pectoris, kulephera kwamtima,
Matumbo: Kutupa msambo, kusowa kudya, pakamwa pouma, kusasangalala pamimba, kudzimbidwa / kutsegula m'mimba, kusanza, cholestasis,
Metabolism: hypoglycemia,
Gulu la masomphenya: zosokoneza malo okhala,
Khungu ndi minyewa yodutsa: photosensitivity reaction, urticaria, zidzolo, kuyabwa, matenda a Stevens-Johnson,
Zina: kupweteka pachifuwa.

Bongo

Mankhwala osokoneza bongo a Glyurenorm angayambitse hypoglycemia, womwe umatsimikiziridwa ndi zizindikiro zotsatirazi: nkhawa yamagalimoto, tachycardia, palpitations, kuyankhula modandaula komanso masomphenya, thukuta kwambiri, njala, kusakwiya, kugona tulo, kupweteka mutu, kunjenjemera, ndi kukomoka. Zizindikiro za hypoglycemia zikawoneka, ndikofunikira kudya zakudya zopatsa thanzi kapena shuga (dextrose).Ngati kwambiri hypoglycemia, limodzi ndi kusazindikira kapena chikomokere, dextrose imayendetsedwa kudzera m'mitsempha. Wodwalayo akayambanso kudziwa bwino, ayenera kudya zakudya zopatsa mphamvu mosavuta kuti asadzadwalidwenso.

Mimba komanso kuyamwa

Zambiri pakugwiritsa ntchito glycidone mwa odwala nthawi yapakati komanso mkaka wa m`mawere sapezeka. Amayi oyembekezera omwe amapezeka ndi matenda ashuga amayenera kuyang'anitsitsa kuchuluka kwa shuga wa m'magazi. Kumwa mankhwala a hypoglycemic amkati mwa odwala pakadali pano sikutanthauza kutsimikizika kwa glycemic. Pachifukwa ichi, kutenga Glyurenorm pa nthawi ya pakati kumapangidwa.

Wodwala akakhala ndi pakati panthawi ya mankhwalawa, kapena akalinganiza, glycidone imathetsedwa ndikuyamba insulin.

Ndi chiwindi ntchito

Glurenorm siyikulimbikitsidwa kwa odwala omwe ali ndi vuto lowopsa la chiwindi, chifukwa 95% ya mankhwalawo amatengedwa imapukusidwa mu chiwindi ndikuchotsa ndowe. Kafukufuku wachipatala omwe odwala omwe ali ndi matenda a shuga komanso kuperewera kwa chiwindi kosiyanasiyana (kuphatikiza matenda oopsa a chiwindi, limodzi ndi portal matenda oopsa) adachitapo kanthu, adawonetsa kuti glycvidone sinayambitse kuwonongeka kwa chiwindi, kuwonjezeka kwa mavuto, komanso kuperewera kwa hypoglycemic. sanali kwina.

Kuyanjana kwa mankhwala osokoneza bongo

N`zotheka kupititsa patsogolo hypoglycemic zotsatira za Glurenorm pamodzi ndi munthawi yomweyo: , sulfonamides, sulfinpyrazone, clofibrate, clarithromycin, chloramphenicol, allopurinol.

Sympatholytics (kuphatikiza clonidine), beta-blockers, guanethidine ndi reserpine sangangokulitsa mphamvu ya hypoglycemic ya Glyrenorm, koma nthawi yomweyo imadzaza zizindikiro za hypoglycemia.

Ndikotheka kuchepetsa zotsatira za hypoglycemic za Glyurenorm pomwe mukupereka mankhwala otsatirawa: sympathomimetics, glucocorticosteroids, mahomoni a chithokomiro, thiazide ndi loop diuretics, kulera kwapakamwa, kukonzekera kwa nicotinic acid, aminoglutetimide, phenothiazine, diazoxide, glucagin.

Pogwiritsa ntchito munthawi yomweyo Mowa, histamine H blockers₂-receptors (mwachitsanzo, ranitidine, cimetidine), ndizotheka zonse kuwonjezera ndi kufooketsa mphamvu ya hypoglycemic ya Glyrenorm.

Mafanizo a Glurenorm ndi awa: Amix, Glair, Glianov, Glibetic, Gliklada.

Kupanga ndi mawonekedwe a kumasulidwa

Glurenorm imapezeka mu mawonekedwe a miyala, yoyera mozungulira yokhala ndi "57C" ndi logo yakampani kumbuyo. Piritsi lililonse limakhala ndi 30 mg yogwira ntchito - glycidone, zigawo zothandizira zimaperekedwa mwanjira ya: lactose monohydrate, mafuta a chimanga chosungunuka, zouma, magnesium. Mapiritsi amadzaza zidutswa 10. M'matumba okhala ndi makatoni 3, 6 kapena 12 ma PC.

Mlingo ndi makonzedwe

Mapiritsi amatengedwa pakamwa. Malangizo omwe amatenga Glenrenorm ndi mlingo wa mankhwalawa amatsimikiza pamaziko a kagayidwe kazachilengedwe.

Nthawi zambiri, koyamba mlingo wa mankhwalawa ndi theka la piritsi, tikulimbikitsidwa kuti mumwera pakudya cham'mawa. Kupitilira apo, ngati kuli kotheka, mlingo umakulitsidwa pang'onopang'ono (malinga ndi malingaliro a dokotala).

Muzochitika zomwe wodwala amapatsidwa mapiritsi 2 patsiku, amatha kumwa kamodzi. Mlingo wapamwamba wa Glenrenorm uyenera kugawidwa pawiri.

Migwirizano ndi magwiritsidwe akusungidwa

Malinga ndi malangizo, Glurenorm iyenera kusungidwa m'malo amdima, owuma komanso osawonekera kwa ana, kutentha kwa firiji.

Kuchokera ku pharmacies, mankhwalawa amaperekedwa ndi mankhwala. Moyo wa alumali wa mapiritsi, malinga ndi malingaliro a wopanga, ndi zaka zisanu. Glurenorm silingagwiritsidwe ntchito tsiku litatha.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Zotsatira za pharmacological

Glurenorm imayambitsa pancreatic and extrapancreatic effect, imathandizira kubisalira kwa insulin (insulin yofunikira kwambiri ya carbohydrate metabolism) ndi maselo a pancreatic beta, pomwe imakulitsa zochitika za insulin, imakhudza kupezeka kwa glucose ndimisempha ndi chiwindi, komanso kupewa lipolysis mu minofu ya adipose. Kuchuluka kwa shuga m'magazi kumayamba kuchepa ola limodzi mutatha kumwa mankhwalawo, mphamvu yake imatheka pambuyo pa maola awiri ndi atatu, kutalika kwa nthawi ya Glenrenorm malinga ndi ndemanga ndi maola 8-10. Glurenorm imalowetsedwa kwathunthu kuchokera kumimba yotsekemera, imapangidwa mu chiwindi ndikuchotsa makamaka m'matumbo ndi 5% yokha mumkodzo.

Glurenorm, pokhala sulfonylurea yotumphukira, ndimankhwala osakhalitsa, chifukwa chake amalimbikitsidwa kuti agwiritsidwe ntchito ndi odwala omwe ali ndi matenda a shuga a 2 omwe ali pachiwopsezo chachikulu cha hypoglycemia (okalamba kapena vuto laimpso). Komanso, mankhwalawa angagwiritsidwe ntchito kwa odwala omwe ali ndi matenda ashuga nephropathy komanso kulephera kwaimpso, chifukwa glycidone imachotsedwa impso ndi ochepa.

Zotsatira za Glenrenorm

Malinga ndi malangizo omwe aphatikizidwa kwa Glurenorm, kugwiritsa ntchito mankhwalawa kumatsutsana:

Zowopsa za chiwindi,
Mtundu woyamba wa shuga
Matenda a shuga komanso matenda opatsirana,
States pambuyo pancreatic resection,
Matenda opatsirana
Mimba komanso nthawi yoyamwitsa,
Opaleshoni yogwira ndi insulin yothandizira,
Galactosemia, kuchepa kwa mkaka wa m'matumbo,
Osakwana zaka 18,
Hypersensitivity mankhwala.

Komanso, mosamala kwambiri, mankhwalawa amaperekedwa kwa odwala omwe ali ndi vuto la chithokomiro, omwe ali ndi febrile syndrome, komanso akuledzera.

Kapangidwe ka mankhwalawo, kufotokozera, ma CD, mawonekedwe

Kodi kukonzekera kwa Glurenorm kumabweretsa mtundu wanji? Malangizo ogwiritsira ntchito amadziwitsa kuti malonda amtunduwu amapezeka mu mawonekedwe a mapiritsi oyera ndi osalala a mawonekedwe ozungulira, ali ndi notch komanso m'mphepete, komanso cholembedwa "57C" ndi logo ya kampani.

Gawo lalikulu la mankhwala omwe amafunsidwa ndi glycidone. Amaphatikizanso wowuma chimanga wowuma, lactose monohydrate, mafuta wowuma a chimanga ndi magnesium stearate (mankhwala ena).

Glurenorm ya mankhwala (mapiritsi) imapitilira kugulitsa m'matumba a zidutswa 10, zomwe zimadzaza m'matakada.

Zotsatira za pharmacological

Kodi mankhwala a Glurenorm ndi ati? Malangizo ogwiritsira ntchito akuti awa ndi othandizira a hypoglycemic, omwe amachokera ku sulfonylurea (m'badwo wachiwiri). Amapangidwira pakamwa pokhapokha.

Mankhwala omwe amafunsidwa ali ndi zotsatira za extrapancreatic ndi pancreatic. Zimathandizira kubisalira kwa insulin ndipo imayendetsa njira ya shuga mkati mwa mapangidwe ake.

Kafukufuku wokhudza nyama yothandizira matenda adawonetsa kuti mankhwalawa "Glyurenorm", malangizo omwe ali pakatoni, amatha kuchepetsa kukana kwa insulini mu minofu ya adipose komanso chiwindi cha wodwalayo. Izi zimachitika pogwiritsa ntchito makina a postreceptor, omwe amalumikizidwa ndi insulin, komanso kuwonjezeka kwa ma receptors ake.

Hypoglycemic zotsatira atatha kumwa mankhwalawa pambuyo 65-95 Mphindi. Zambiri za kuchuluka kwa mankhwalawa, zimachitika pambuyo pa maola pafupifupi 2-3 ndipo zimatha pafupifupi maola 8-10.

Katundu wa Kinetic

Malangizo ogwiritsira ntchito "Glyurenorm" akuti kugwiritsa ntchito limodzi muyezo wa mankhwalawa (15-30 mg) kumathandizira kuyamwa kwake mwachangu komanso kwathunthu kuchokera m'matumbo am'mimba (pafupifupi 80-95%). Amafika pachimake pa ndende yake patatha maola awiri.

Chithandizo chogwira mankhwalawa chimakonda kwambiri mapuloteni a plasma.

Palibe zambiri pa gawo la glycidon kapena zotumphukira zake mwa placenta kapena BBB. Palibenso chidziwitso pazilowedwe za glycidone mkaka wa m'mawere.

Kodi kagayidwe kake ka mankhwala "Glyurenorm" kali kuti? Malangizo ogwiritsira ntchito akuti mankhwala omwe amafunsidwa amaphatikizidwa m'chiwindi kudzera mu demethylation ndi hydroxylation.

Kuchuluka kwa zochuluka za glycidone zimachokera m'matumbo. Hafu ya moyo wa mankhwalawa ndi maola 1-2.

Kwa odwala okalamba komanso azaka zapakati, magawo a kinetic a Glyurenorm ndi ofanana.

Malinga ndi akatswiri, kagayidwe ka mankhwalawa sikasintha mwa odwala omwe ali ndi vuto la chiwindi. Tiyeneranso kudziwa kuti odwala omwe ali ndi vuto laimpso, mankhwalawa sadziunjikira.

Kodi mankhwalawa amagwiritsidwa ntchito motani? Malangizo ogwiritsira ntchito, ndemanga zikuwonetsa kuti chisonyezo chogwiritsidwa ntchito ndi mtundu wa 2 matenda a shuga mwa anthu okalamba komanso azaka zapakati (osagwiritsa ntchito mankhwalawa pakudya).

Zoletsa kumwa mankhwala

Ndi nthawi ziti zomwe zimalephereka kuti mupereke mapiritsi a Glurenorm? Malangizo ogwiritsira ntchito akuwonetsa zotsutsana zotsatirazi pamankhwala awa:

Porphyria alternating pachimake,
mtundu 1 shuga
kulephera kwambiri kwa chiwindi,
diabetesic acidosis, precoma, ketoacidosis ndi chikomokere,
nthawi yapadera yapa kapamba,
Matenda achilengedwe obadwa nawo monga galactosemia, tsankho lactose, kusowa kwa lactase ndi glugose-galactose malabsorption,
zovuta za wodwala (mwachitsanzo, opaleshoni yayikulu, matenda opatsirana),
nthawi yapakati
zaka zazing'ono (chifukwa chosakwanira ndi chitetezo cha mankhwalawa mu gulu laka lino),
nthawi yoyamwitsa
Hypersensitivity kuti sulfonamides.

Mankhwala "Glurenorm": malangizo ogwiritsira ntchito

Mapiritsi a Glurenorm amadziwika okha mkati. Mukamamwa, muyenera kutsatira malangizo onse a dokotala pokhudzana ndi kuchuluka kwa mankhwalawa komanso zakudya. Ndi zoletsedwa kusiya kumwa mankhwalawo osakambirana kaye ndi katswiri.

Mlingo woyambirira wa mankhwala omwe amafunsidwa ndi mapiritsi 0,5 (i.e. 15 mg) pa kadzutsa koyamba. Mankhwalawa amayenera kumwedwa kumayambiriro kwa chakudyacho. Mukatha kudya, kudumpha zakudya ndizoletsedwa.

Ngati kugwiritsa ntchito piritsi la 1/2 sikubweretsa kusintha, ndiye mutatha kufunsa dokotala, mlingo wake umakulitsidwa pang'onopang'ono. Ngati muli ndi mapiritsi a tsiku lililonse a "Glyurenorm" osaposa 2 mapiritsi, akhoza kumwa kamodzi pakudya kadzutsa.

Ngati dokotala wakupatsani mitundu yayikulu ya mankhwalawa, ndiye kuti iyenera kugawa bwino pazigawo ziwiri kapena zitatu.

Kuchulukitsa mlingo wa mapiritsi opitilira anayi patsiku nthawi zambiri sikukula mphamvu zawo. Chifukwa chake, kumwa mankhwalawa "Glyurenorm" mopitilira muyeso womwe sukulimbikitsidwa sikulimbikitsidwa.

Kwa anthu omwe ali ndi vuto la impso, kusintha kwa mankhwalawa sikofunikira.

Kumwa mankhwala opitilira 75 mg mwa odwala omwe ali ndi vuto la chiwindi kumafuna kuwunika pafupipafupi ndi dokotala.

Ngati osakwanira achire kwenikweni, pamodzi ndi "Glurenorm" wodwala akhoza kupatsidwa "Metformin".

Milandu yambiri

Kutenga Mlingo wambiri wa mankhwala a sulfonylurea nthawi zambiri kumabweretsa hypoglycemia. Kuphatikiza apo, mankhwala osokoneza bongo amatha kuyambitsa zotsatirazi: thukuta, tachycardia, kusakwiya, njala, kupweteka kwa mutu, kugwedezeka, kunjenjemera, kusowa tulo, nkhawa zamagalimoto, kusawona bwino komanso kulankhula.

Zizindikiro za hypoglycemia zikawoneka, muyenera kudya glucose kapena zakudya zamafuta ambiri.

Zotsatira zoyipa

Tsopano mukudziwa chifukwa chake mankhwala monga Glurenorm amadziwika. Malangizo ogwiritsira ntchito mankhwalawa awunikiranso pamwambapa.

Malinga ndi odwala, mukumwa mankhwalawa, mutha kukumana:

thrombocytopenia, angina pectoris, agranulocytosis,
paresthesia, hypoglycemia, chizungulire,
leukopenia, mutu, kugona kunja, kugona.
zosokoneza malo, kutopa, hypotension,
kulephera kwamtima, pakamwa pouma, matenda a Stevens-Johnson,
kudya kwakachepa, kusowa kwa photosensitivity, nseru, zotupa,
urticaria, kusanza, kupweteka pachifuwa, cholestasis,
kudzimbidwa, kuyabwa kwa khungu, kutsekula m'mimba, kusapeza bwino pamimba.

Zochita Zamankhwala

Ndi munthawi yomweyo makonzedwe a glycidone ndi Allopurinol, ACE zoletsa, mankhwala antifungal, analgesics, coumarin zotumphukira, NSAIDs ndi ena, zotsatira za hypoglycemic zakale zitha kupititsidwa patsogolo.

Rifampicin, barbiturates, komanso Phenytoin amachepetsa mphamvu ya hypoglycemic ya Glyurenorm.

Malangizo apadera

Hypoglycemic wothandizira pakamwa sayenera kulowa m'malo mwa chithandizo chamankhwala.

Anthu omwe ali ndi matenda ashuga ayenera kutsatira mosamalitsa malingaliro onse a dokotala.

Zizindikiro za hypoglycemia zikawoneka, muyenera kudya nthawi yomweyo zakudya zomwe zimakhala ndi shuga.

Zochita zolimbitsa thupi zitha kupititsa patsogolo zotsatira za hypoglycemic.

Chifukwa chakuti kuwonongeka kwa glycidone ndi impso ndi kofunikira, mankhwalawa atha kufotokozedwa mosamala kwa odwala omwe ali ndi vuto la impso, komanso matenda a shuga.

M'maphunziro azachipatala, zidapezeka kuti kugwiritsidwa ntchito kwa mankhwalawa kwa miyezi 30 sikunathandize pakuwonjezeka kwa odwala. Kuphatikiza apo, pakhala pali milandu yochepetsa thupi ndi 1-2 kg.

Analogs ndi ndemanga

Mankhwala otsatirawa amatchulidwa kwa ma Glurenorm analogues: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Ndemanga za mankhwala omwe amafunsidwa atha kupezeka mosiyana kwambiri. Malinga ndi malipoti a ogula, mankhwalawa ndi othandiza kwambiri komanso opezeka kwa aliyense. Komabe, ziyenera kudziwidwa kuti odwala ambiri ali ndi nkhawa kwambiri chifukwa cha mndandanda wazotsatira zamtunduwu. Ngakhale madotolo amati ndi osowa kwambiri komanso nthawi zina.