Fraxiparin njira analogue

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Fraxiparin. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogwiritsa ntchito mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Fraxiparin pochita zawo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Ma Analogs a Fraxiparin pamakhala ma analogues omwe amapezeka. Gwiritsani ntchito mankhwalawa komanso kupewa thrombosis ndi thromboembolism mwa akulu, ana, komanso pa nthawi ya bere.

Fraxiparin - ndi ochepa maselo wolemera heparin (NMH) wopezeka ndi depolymerization kuchokera ku heparin wokhazikika, ndi glycosaminoglycan wokhala ndi ma molekyulu pafupifupi ma 4300 daltons.

Imawonetsa kuthekera kwakukulu kumangiriza mapuloteni a plasma ndi antithrombin 3 (AT 3). Kumangiriza kumeneku kumabweretsa chiwopsezo chophatikizira cha 10a, chomwe chimapangitsa antithrombotic kuti azitha nadroparin (yogwira mankhwala a Fraxiparin).

Njira zina zopereka antithrombotic zotsatira za nadroparin zimaphatikizanso kutsegula kwa minyewa ya kusintha kwa inhibitor (TFPI), kutsegula kwa fibrinolysis pomasulidwa mwachindunji kwa minofu ya plasminogen activell maselo a endothelial, ndikusintha kwamitsempha yamagazi ndi kuchepa kwamphamvu kwa kupatsidwa magazi kuundana.

Calcium nadroparin imadziwika ndi anti-10a factor zochita kwambiri poyerekeza ndi anti-2a factor kapena antithrombotic zochita ndipo imakhala ndi zochitika zapantchito zamtundu wa antithrombotic.

Poyerekeza ndi heparin yopanda kukonzekera, nadroparin imakhala yocheperako pakugwira ntchito ya maplatelet ndi kuphatikiza, komanso samatchulidwa kwenikweni pa hemostasis yapamwamba.

Mlingo wa prophylactic, Fraxiparin siyambitsa kuchepa kutchulidwa kwa APTT.

Ndi chithandizo cha mankhwala munthawi ya zochitika zapamwamba, kuwonjezeka kwa APTT pamtengo 1.4 nthawi zambiri kuposa momwe mungathere. Kutalika kotereku kumatsalira otsalira a antithrombotic mphamvu ya calcium nadroparin.

Kupanga

Calcium calcium nadroparin.

Pharmacokinetics

Facacokinetic katundu amatsimikiza pamaziko a kusintha kwa ntchito ya anti-10a plasma.

Fraxiparin imayamwa pafupifupi kwathunthu (pafupifupi 88%). Mothandizidwa ndi mtsempha wa intravenous, ntchito yotsutsana ndi 10a imatheka pang'onopang'ono mphindi 10. Zimapangidwa makamaka mu chiwindi mwa kuwonongedwa ndi depolymerization.

Zotsatira za phunziroli zidawonetsa kuti kudziunjikira pang'ono kwa nadroparin kumatha kuwonedwa mwa odwala omwe amalephera kupweteka pang'ono kapena pang'ono (CC ≥ 30 ml / min and and

Malangizo ogwiritsira ntchito ndi mlingo

Momwe mungapangire jakisoni wa Fraxiparin - njira ya jekeseni

Mothandizidwa ndi subcutaneally, mankhwalawa amathandizira wodwalayo pamalo apamwamba, m'matumbo a anterolateral kapena posterolateral padziko pamimba, mbali imodzi kumanja ndi kumanzere. Adaloledwa kulowa ntchafu.

Pofuna kupewa kuwonongeka kwa mankhwalawa pogwiritsa ntchito syringes, thovu la mpweya sayenera kuchotsedwa jakisoni.

Singano iyenera kuyikika paliponse, osati pakona, pakhungu lokhazikika pakati pa chala chachikulu. Khola liyenera kusungidwa nthawi yonse ya mankhwala. Osapukuta tsamba la jakisoni mutatha jakisoni.

Pofuna kupewa thromboembolism machitidwe ambiri opangira opaleshoni, muyezo wa Fraxiparin ndi 0,3 ml (2850 anti-10a ME) s / c. Mankhwala chikuyendetsedwera 2-4 mawola musanachite opaleshoni, ndiye - 1 nthawi patsiku. Chithandizo chimapitilizidwa kwa masiku osachepera 7 kapena nthawi yonse ya chiwopsezo cha thrombosis, kufikira wodwalayo atakonzedwa.

Pofuna kupewa thromboembolism panthawi ya mafupa, Fraxiparin imayang'aniridwa pang'onopang'ono pamtengo womwe umatsimikiziridwa malinga ndi kuchuluka kwa thupi la wodwala pamlingo wa 38 anti-10a IU / kg, womwe ukhoza kuwonjezeka mpaka 50% patsiku la 4 la ntchito. Mlingo woyambirira umaperekedwa maola 12 asana opaleshoni, mlingo wachiwiri - maola 12 atatha opareshoni. Kupitilira apo, Fraxiparin imapitilizidwa kugwiritsidwa ntchito kamodzi patsiku nthawi yonse ya chiwopsezo cha thrombosis mpaka wodwalayo atamuika kumalo ena. Kutalika kochepa kwa mankhwala ndi masiku 10.

Pochiza matenda osakhazikika a angina pectoris ndi myocardial infarction popanda Q wave, Fraxiparin amamuika sc 2 kawiri pa tsiku (maola 12 aliwonse). Kutalika kwa mankhwala nthawi zambiri 6 masiku. M'maphunziro azachipatala, odwala omwe ali ndi vuto losakhazikika la angina pectoris / myocardial infarction popanda Q wave Fraxiparin adayikidwa limodzi ndi acetylsalicylic acid pa mlingo wa 325 mg tsiku lililonse.

Mlingo woyambirira umaperekedwa ngati jekeseni imodzi yamitsempha, Mlingo wotsatira umaperekedwa. Mlingo umayikidwa kutengera kulemera kwa thupi pamlingo wa 85 anti-10a IU / kg.

Mankhwala a thromboembolism, mankhwala oteteza pakamwa (pakakhala kuti pali ma contraindication) ayenera kutumikiridwa posachedwa. Chithandizo cha Fraxiparin sichimayimitsidwa mpaka zomwe zimatsimikiziridwa pazotsimikizira nthawi ya prothrombin zitheke. Mankhwala wolembedwa 2/2 kawiri pa tsiku (maola 12 aliwonse), nthawi yokhazikika pamaphunzirowa ndi masiku 10. Mlingo umatengera kulemera kwamthupi la wodwalayo kutengera thupi 90 la anti-10a IU / kg.

Zotsatira zoyipa

• magazi amitundu ingapo,
• thrombocytopenia
• eosinophilia, kusintha pambuyo mankhwala
• Hypersensitivity zimachitika (edema wa Quincke, zimachitika pakhungu),
• mapangidwe a hematoma yaing'ono subcutaneous pamalo a jakisoni,
• khungu necrosis, nthawi zambiri pamalowa jakisoni,
• chidwi
• hyperkalemia yosinthika (yogwirizana ndi kuthekera kwa heparins kupondereza katulutsidwe ka aldosterone, makamaka kwa odwala omwe ali pachiwopsezo).

Contraindication

• thrombocytopenia ndi mbiri ya nadroparin,
• Zizindikiro za kutuluka magazi kapena chiwopsezo chotaya magazi chifukwa chodwala (heparin), kupatula DIC yopanda heparin.
• organic kuwonongeka ndi chizolowezi kutaya magazi (mwachitsanzo, zilonda zam'mimba kapena zilonda zam'mimba),
• kuvulala kapena kulowererapo kwa bongo ndi msana kapena m'maso,
• intracranial hemorrhage,
• pachimake septic endocarditis,
• kulephera kwambiri kwa aimpso (CC

Mndandanda wa mankhwala Fraxiparin

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 2164.

Wessel Douay F ndi wogwira ntchito pokhazikika wokhazikika pa sulodexide mu Mlingo wa 250 LE. Itha kuthandizidwa pochiza matenda amisala, kuchepa kwa mitsempha, mitsempha yayikulu ndi matenda ena.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 527.

Wopanga: Sanofi Winthrop Viwanda (France)
Kutulutsa Mafomu:

• Syringe 10,000. Anti-ChAME / ml 0,6 ml, ma PC 2., Mtengo kuchokera pa ma ruble 826

Mitengo ya Clexane pamafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

Clexane ndi wogwirizira wotsogola waku France. Amapezeka mu mawonekedwe a yankho lomwe lili ndi enoxaparin sodium. Amawerengera ngati prophylactic ya venous thrombosis, komanso mankhwalawa akutsempha kwamitsempha. Pa mimba ndi mkaka wa m`mawere zitha kuperekedwa pokhapokha pokhapokha.

Analogue ndiokwera mtengo kwambiri kuchokera ku 1428 rubles.

Anfibra ndi analogue yotsika mtengo pang'ono yopanga zoweta zapakhomo. Kugulitsidwa mu phukusi la ma ampoules 10, omwe ali ndi enoxaparin sodium. Chifukwa cha kusiyana kwazomwe zimapangidwira, zimatha kukhala ngati choloweza m'malo pokhapokha ngati dokotala wasankhidwa.

Analogue ndiokwera mtengo kwambiri kuchokera ku 1868 rubles.

Angioflux ndi mankhwala achi Russia ochokera mgulu lofananalo la mankhwala. Amasiyana ndi Fragmin popanga, koma ali ndi mawonekedwe ofanana. Itha kuperekedwa kwa angiopathy, chiopsezo chowonjezereka cha thrombosis, magawo oyamba a miyendo yotsika ya ischemia. Pali zosiyana mu contraindication komanso zotheka zoyipa.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble a 1256.

Wopanga: Vetter Pharma-Fertigung GmbH (Germany)
Kutulutsa Mafomu:

• Syringe 2500 IU, 0,2 ml, ma PC 10., Mtengo kuchokera 155 rubles

Mitengo ya Fragmin muma pharmacistine opezeka pa intaneti
Malangizo ogwiritsira ntchito

Fragmin ndi mankhwala opangidwa ndi Germany opangidwa mwa njira yothetsera kukhazikika kwa ma intravenous and subcutaneous. Itha kuperekedwa pochiza matenda oopsa a m'mitsempha yotupa komanso pulmonary embolism, angina osakhazikika ndi kulowerera kwa myocardial (popanda Q wave pa ECG), komanso kupewa thrombosis pa nthawi ya opaleshoni.

Analogue ndiokwera mtengo kwambiri kuyambira 1418 rubles.

Enixum ndi m'malo mwa Wessel Douay F anticoagulant kanthu, omwe ali ndi mawonekedwe ofanana. Zosiyanasiyana kuchokera koyambirira pazomwe zimagwirira - enoxaparin sodium. Mankhwalawa amaperekedwa mosamala kwambiri kapena m'mitsempha. Chitetezo ndi kuthekera kwa kupereka mankhwalawa kwa ana osakwana zaka 18 sizinaphunzire.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 134.

Wopanga: Italfarmako S.p.A. (Italy)
Kutulutsa Mafomu:

• Syringe 10,000 anti-Ha ME / ml 0,2 ml, 1 pc., Mtengo kuchokera pa ma ruble 165

Mitengo ya Gemapaxan muma pharmacistine apamtaneti
Malangizo ogwiritsira ntchito

Chotchipa chopangidwa ndi Italy. Wogulitsidwa mu njira yankho la subcutaneous makonzedwe ndi enoxaparin sodium mu Mlingo kuyambira 2000 mpaka 6000 IU umagwiritsidwa ntchito ngati chogwira ntchito. Malinga ndi zazikuluzikulu zowonetsera kusankhidwa kwake, ndizofanana ndi Clexane ndipo adalembedwanso chifukwa cha thrombosis (chithandizo ndi kupewa).

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandiza Fraxiparin ndi chiyani? Malinga ndi malangizo, mankhwalawa amalembedwa motere:

• kupewa zovuta za thromboembolic munthawi ya ma opaleshoni wamba kapena a mafupa,
• Odwala omwe ali ndi chiopsezo chachikulu cha matenda a thromboembolic (kupuma komanso / kapena matenda opatsirana a kupuma, ndi / kapena kulephera kwa mtima) amagonekedwa m'chipinda chachipatala cha odwala kwambiri,
• kupewa kupewera kwa magazi pa hemodialysis, mankhwalawa osakhazikika angina ndi myocardial infarction popanda mafinya a Q osagwirizana pa ECG.

Malangizo ntchito Fraxiparin, mlingo

Mothandizidwa ndi subcutaneally, mankhwalawa amathandizira wodwalayo pamalo apamwamba, m'matumbo a anterolateral kapena posterolateral padziko pamimba, mbali imodzi kumanja ndi kumanzere. Adaloledwa kulowa ntchafu.

Pofuna kupewa kuwonongeka kwa mankhwalawa pogwiritsa ntchito syringes, thovu la mpweya sayenera kuchotsedwa jakisoni.

Singano iyenera kuyikika paliponse, osati pakona, pakhungu lokhazikika pakati pa chala chachikulu. Khola liyenera kusungidwa nthawi yonse ya mankhwala. Osapukuta tsamba la jakisoni mutatha jakisoni.

• Pofuna kupewa matenda a thromboembolism ambiri, muyezo wa Fraxiparin ndi 0,3 ml (2850 anti-Xa ME) s / c. Mankhwala chikuyendetsedwera 2-4 mawola musanachite opaleshoni, ndiye - 1 nthawi patsiku. Chithandizo chimapitilizidwa kwa masiku osachepera 7 kapena nthawi yonse ya chiwopsezo cha thrombosis, kufikira wodwalayo atakonzedwa.
• Pofuna kupewa thromboembolism pa nthawi ya mafupa, Fraxiparin imayang'aniridwa pang'onopang'ono pamtengo womwe umayikidwa malinga ndi kuchuluka kwa thupi la wodwala pamlingo wa 38 wotsutsa XA IU / kg, womwe ukhoza kuwonjezeka mpaka 50% patsiku la 4 la ntchito. Mlingo woyambirira umaperekedwa maola 12 asana opaleshoni, mlingo wachiwiri - maola 12 atatha opareshoni. Kupitilira apo, Fraxiparin imapitilizidwa kugwiritsidwa ntchito kamodzi patsiku nthawi yonse ya chiwopsezo cha thrombosis mpaka wodwalayo atamuika kumalo ena. Kutalika kochepa kwa mankhwala ndi masiku 10.
• Odwala omwe ali ndi chiopsezo chachikulu cha thrombosis (nthawi zambiri imakhala m'chipinda chothandizira kwambiri / chisamaliro chachikulu cha odwala / kupuma movutikira komanso / kapena kupuma kwamatenda ndi / kapena kulephera kwa mtima /) Fraxiparin amapatsidwa nthawi / tsiku 1 pa mlingo womwe umadalira thupi wodwala. Ikani ntchito nthawi yonse ya chiwopsezo cha thrombosis.
• Pochiza matenda osakhazikika a angina pectoris ndi myocardial infarction popanda Q wave, s / c amalembedwa 2 kawiri pa tsiku (maola 12 aliwonse). Kutalika kwa mankhwala nthawi zambiri 6 masiku. M'maphunziro azachipatala, odwala omwe ali ndi vuto losakhazikika la angina pectoris / myocardial infarction popanda Q wave Fraxiparin adayikidwa limodzi ndi acetylsalicylic acid pa mlingo wa 325 mg / tsiku. Malangizo ogwiritsira ntchito amalimbikitsa kuti muyeso woyamba kutumikiridwa ngati jekeseni imodzi yamkati, Mlingo wotsatira umaperekedwa s.c. Mlingo umayikidwa kutengera kulemera kwa thupi pamlingo wa 86 anti-XA IU / kg.
• Mankhwala a thromboembolism, mankhwala oteteza pakamwa (pakakhala kuti pali ma contraindication) ayenera kutumikiridwa posachedwa. Mankhwala samayimitsidwa mpaka zitsimikiziro zofunika za chisonyezo cha nthawi ya prothrombin zitheke. Mankhwala wolembedwa 2/2 kawiri pa tsiku (maola 12 aliwonse), nthawi yokhazikika pamaphunzirowa ndi masiku 10. Mlingo umatengera kulemera kwamthupi la wodwala pamlingo wa 85 anti-XA ME / kg thupi.

Malangizo apadera

Osaba jakisoni intramuscularly!

Odwala omwe ali ndi chiopsezo chowonjezereka cha magazi, mutha kugwiritsa ntchito theka la mankhwalawa.

Ngati dialysis gawo limatenga maola opitilira 4, mankhwala ena owonjezera amatha kuperekedwa.

Okalamba odwala, kusintha kwa mankhwala sikofunikira (kupatula odwala omwe ali ndi vuto laimpso). Musanayambe chithandizo ndi Fraxiparin, tikulimbikitsidwa kuwunika mawonetseredwe aimpso.

Odwala omwe ali ndi kufatsa kwambiri aimpso (CC ≥ 30 ml / min ndi.)

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Ndidafunsa adotolo clexane kapena fraksiparin bwino. Adokotala ananena kuti motsimikizika fraksiparin. Osachepera chifukwa chizolowezi chogwiritsa ntchito mankhwalawa mwa amayi apakati ndiwofalikira komanso wowerengeka.