Rosart: malangizo ogwiritsira ntchito, zikuonetsa, malingaliro ndi ma fanizo

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Rosart - mankhwala okhudzana ndi ma statins, omwe amagwiritsidwa ntchito kutsitsa cholesterol yamagazi. Mankhwala Rosart monga yogwira pophika amakhala ndi rosuvastatin. Mankhwalawa amapezeka mu mawonekedwe a mapiritsi a 5, 10, 20 ndi 40 mg mu mawonekedwe a Actavis Gulu ku Iceland. Rosart imagwiritsidwa ntchito kwambiri pochiza hypercholisterinemia.

• Zisonyezero zamankhwala
• Chithandizo cha zakudya ndi statin
• Malamulo a Rosart
• Kodi Ndingatani Kuti Ndimugwiritse Ntchito Rosart?
• Mimba komanso kudyetsa mwana
• Gwiritsani ntchito Rosart mosamala
• Zotsatira zoyipa
• Mitu ya mankhwalawa

Rosart ali ndi mankhwala awa:

• kutsitsa mafuta m'thupi - lipoproteins otsika,
• kutsitsa kiwango cha cholesterol A - lipoprotein otsika kwambiri,
• kutsitsa cholesterol yathunthu ndi triglycerides m'magazi,
• kutsitsa mafuta m'thupi - liproteins okwera,
• amachepetsa osiyanasiyana kuchuluka kwa mafuta m'thupi - lipoproteins okwera komanso otsika.
• zimakhudza mulingo wa alipoproteins A ndi B.

Hypolipidemic zotsatira za Rosart zimatengera mlingo womwe umagwiritsidwa ntchito. Pambuyo pa chiyambi cha mankhwala a Rosart, njira yothandizira achiwonetsero imawonekera patatha sabata limodzi, pambuyo pa masabata awiri imafika 90%, ndipo patatha milungu inayi yogwiritsira ntchito mphamvu yayikulu yamankhwala imatheka ndipo imakhalabe pamlingo uwu. Mankhwalawa amalowetsedwa m'matumbo am'mimba, amaphatikizidwa m'chiwindi ndikuwachotsa mpaka m'matumbo, komanso pang'ono ndi impso.

Kodi chimathandiza Rosart ndi chiyani?

Rosart, chithunzi cha mapiritsi

Zowonetsa kugwiritsa ntchito mankhwalawa ndi motere:

• hypercholesterolemia kapena hyperlipoproteinemia yophatikizika,
• cholowa cholowa m'magazi, chosagwiritsidwa ntchito pakudya ndi njira zina zosagwiritsa ntchito mankhwala,
• kuchuluka kwa triglycerides,
• kuti muchepetse kupita patsogolo kwa atherosulinosis,
• monga kupewa kwakukulu kwa zovuta zamatenda amtima (matenda a mtima, matenda a mtima, ischemia).

Kutulutsa mawonekedwe ndi kapangidwe kake

Rosart imapezeka ngati mapiritsi okhala ndi filimu: biconvex, mbali ina amalembedwa "ST 1" pamapiritsi azizungulira, "ST 2" ndi "ST 3" pamapiritsi ozungulira pinki, "ST 4" pa mapiritsi okhala ndi mawonekedwe ozungulira a pinki (m'matumba: ma 7 ma PC., pamatoni akunyamula matuza 4, ma PC 10., pamatumba okhala ndi matuza 3 kapena 9 matuza, ma PC 14.

Piritsi limodzi lili:

• yogwira mankhwala: rosuvastatin calcium - 5.21 mg, 10.42 mg, 20,84 mg kapena 41.68 mg, izi ndizofanana ndi zomwe zili mg 5 mg, 10 mg, 20 mg kapena 40 mg wa rosuvastatin, motero.
• othandizira: lactose monohydrate, microcrystalline cellulose (mtundu 102), calcium hydrogen phosphate dihydrate, crospovidone (mtundu A), magnesium stearate,
• makina ophatikizira amakanema: mapiritsi oyera - oyera Opadry II 33G28435 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin, macrogol-3350), mapiritsi a pinki - Opadray pink II 33G240007 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin , macrogol-3350, utoto wa carmine wofiira).

Malangizo a Rosart, ntchito

Rosart imatha kutengedwa nthawi iliyonse masana, mosasamala chakudya. Ndikofunikira kwa wodwala panthawi ya mankhwalawa kuti azitsatira zakudya zowonjezera, zomwe zimapangitsa kuti pakhale kukana mafuta ambiri.

Mlingo amasankhidwa mosiyanasiyana payekhapayekha ndipo zimatengera zinthu monga maulalo a cholesterol, kukhalapo kwa matenda a mtima ndi matenda ammimba.

Kumayambiriro kwa chithandizo chamankhwala, mulingo woyenera tsiku lililonse ndi 5 kapena 10 mg. Kuwunika kwa mankhwalawa kumachitika pakatha milungu inayi: ngati kuchuluka kwa cholesterol "yabwino" sikunakhale koyenera, ndiye kuti mankhwalawa amawonjezeka mpaka 20 mg, ndipo ngati ndi kotheka, mpaka 40 mg.

Wodwala akalandira mlingo wovomerezeka, ndiye kuti amafunika kumuyang'anira pafupipafupi, popeza pamakhala chiopsezo chambiri chodwala.

Malangizo ogwiritsira ntchito Rosart makamaka amakopa chidwi chokhudzana ndi mankhwala ndi mankhwala ena:

1. Ngati wodwala akutenga mankhwala a cyclosporine, ndiye kuti mlingo wa Rosart ndi 5 mg.

2. Mankhwala Hemofibrozil amafanana ndi a Rosar ofanana, motero, onse a mankhwalawa amayenera kumwedwa mosamala.

3. Protease inhibitors (mankhwala ochepetsa mphamvu ya kachilombo ka antiretroviral omwe amaperekedwa kuti apewe chitetezo cha mthupi, mankhwala - Agenerase, Crixivan, Virasept, Aptivus) amatseketsa enzyme yomwe imayambitsa kuphwanya kwa polyproteins. Chifukwa chake, ngati wodwala atenga Rosart ndi mankhwalawa, ndiye kuti mphamvu yake yotsirizira imachulukanso katatu. Pankhaniyi, mulingo woyenera kwambiri wothandizidwa ndi lipid sayenera kupitirira 10 mg.

Mankhwala ayenera kutsukidwa ndi madzi okwanira, kutafuna mapiritsi osavomerezeka.

Contraindication ndi bongo

Kuwonongeka kwambiri kwa impso, matenda a chiwindi omwe amagwira ntchito ndi minyewa ya dystrophy, mapiritsi sinafotokozedwe. Rosart simalimbikitsidwanso kwa amayi omwe akukonzekera kutenga pakati.

Zotsutsana zina - nthawi yonse ya kubereka, mkaka wa m'mawere (ndi yoyamwitsa) ndi ana osakwana zaka 18.

Mlingo wokwanira sukhazikitsidwa ngati wodwala ali ndi vuto la hypothyroidism (kusowa kwa mahomoni a chithokomiro) kapena amwa zakumwa zoledzeretsa (mwanjira iyi, mlingo wofatsa umalimbikitsidwa kapena mankhwalawo sanalembedwe konse). Mapiritsi amawayikira mosamala odwala omwe wachibale wawo ali ndi vuto la minyewa ya dystrophic. Kwa anthu amtundu wa Mongoloid, mankhwalawa amalamulidwa mosamalitsa.

Nthawi zina, kumwa mankhwalawa kumatha kuyambitsa zotsatirazi zotsatirazi:

• matupi awo saonekera pakhungu.
• chizungulire, kupweteka mutu, kufooka kwa minofu,
• kuphwanya ntchito ya endocrine, kuwonetsedwa pakupanga matenda a shuga 1
• kutopa msanga ndi kutopa,
• kuthamanga kwa magazi, palpitations.

Wodwala samalimbikitsidwa kuti azitha kusintha yekha mlingo wokwera. Kupanda kutero, zizindikiro za bongo zingakhale:

• nseru, kusanza, mapando otayirira,
• kupweteka m'mimba
• khungu, kusazindikira.
• kuphwanya kupuma ndi kugunda kwa mtima.

Ngati zoterezi zikuchitika, chisamaliro chamankhwala ayenera kulimbikitsidwa mwachangu, ndipo madokotala asanafike, pezani m'mimba mwa wodwalayo.

Mankhwala

Rosart ndi mankhwala ochokera ku gulu la ma statins okhala ndi ntchito yokhala ndi lipid. Zomwe zimagwira, rosuvastatin, ndi mpikisano wosankha wa 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), enzyme yomwe imatembenuza HMG-CoA kukhala mevalonate, chotsogola cholesterol.

Powonjezera kuchuluka kwa otsika kwambiri a lipoprotein receptors (LDL) pamtunda wa hepatocytes, rosuvastatin imakulitsa kukhudzana ndi katemera wa LDL, imalepheretsa kaphatikizidwe kakang'ono kwambiri ka lipoproteins (VLDL) ndikuchepetsa kuchuluka kwathunthu kwa LDL ndi VLDL. Amatsitsa kuchuluka kwa LDL cholesterol, cholesterol yathunthu, triglycerides (TG), cholesterol ya VLDL, TG-VLDL, cholesterol yopanda HDL (high density lipoproteins), apolipoprotein B (ApoV). Zimayambitsa kuwonjezeka kwa kuchuluka kwa cholesterol ya HDL ndi ApoA-I. Imachepetsa kuchuluka kwa cholesterol-LDL ku cholesterol-HDL, cholesterol yathunthu kupita ku cholesterol-HDL, cholesterol yopanda HDL kupita ku cholesterol ya HDL, apolipoprotein B (ApoB) kupita ku apolipoprotein A-I (ApoA-I).

Hypolipidemic zotsatira za Rosart zimatengera mwachindunji kuchuluka kwa mlingo womwe wapatsidwa. Zotsatira zakuchizira zimachitika sabata yoyamba ya mankhwala, pakatha milungu iwiri imafika 90% ya mphamvu yayikulu, ndipo pofika sabata lachinayi - 100% ndipo imakhalabe yosasintha. Rosuvastatin akuwonetsedwa zochizira hypercholesterolemia popanda / ndi hypertriglyceridemia, mosaganizira jenda, zaka kapena mtundu wa wodwalayo, kuphatikiza odwala omwe ali ndi matenda osokoneza bongo komanso hypercholesterolemia. Zotsatira za kafukufukuyu zikuwonetsa kuti mutatenga Rosart pa mlingo wa 10 mg wa mtundu IIa ndi IIb hypercholesterolemia (gulu la Fredrickson) wokhala ndi cholesterol yayikulu ya LDL ya 4,8 mmol / L, LDL cholesterol concentration imafika pazosakwana 3 mmol / L mu 80 % ya odwala. Ndi homozygous achibale hypercholesterolemia, kutsika kwapakati kwa LDL cholesterol kuchuluka ndi rosuvastatin pa 20 mg ndi 40 mg ndi 22%.

Mphamvu yowonjezera pakuphatikiza kwa Rosart ndi nicotinic acid pa mlingo wa 1000 mg kapena kuposa patsiku (mogwirizana ndi kuchuluka kwa cholesterol ya HDL) ndi fenofibrate (mogwirizana ndi kuchepa kwa kuchuluka kwa TG) kumadziwika.

Pharmacokinetics

Mutamwa piritsi C_max (kuchuluka kwa ndende) ya rosuvastatin m'madzi am'magazi imatha kufikira pafupifupi maola 5. Kudziwulutsa kwake kantchito kumawonjezeka molingana ndi mlingo womwe umamwa. Mtheradi bioavailability pafupifupi 20%. Magawo a tsiku ndi tsiku a pharmacokinetic sasintha.

Kulumikizana ndi mapuloteni am'madzi am'magazi (kwakukulu ndi albumin) kuli pafupifupi 90%. Kuchepetsa kwa pakhungu kumachitika m'chiwindi. V_d (voliyumu yogawa) - 134 l. Mankhwala amathana ndi chotchinga chachikulu.

Ndi gawo lopanda chapakati pazesoenzymes za cytochrome P system₄₅₀. Pafupifupi 10% ya rosuvastatin ndi biotransformed mu chiwindi. Kuchita kwa rosuvastatin kukhudzana ndi chiwindi kumachitika ndi gawo la chonyamula membrane - polypeptide, yomwe imayendetsa organic anion (OATP) 1B1 ndipo imathandizira pakuchotsa kwina kwa hepatic. Isoenzyme CYP2C9 ndiye isoenzyme yayikulu ya metabolism ya rosuvastatin, mpaka ochepera CYP3A4, CYP2C19 ndi CYP2D6.

Ma metabolites akuluakulu a rosuvastatin ndi othandiza paacactic metabolites ndi N-desmethyl, omwe ndi 50% osagwira kuposa rosuvastatin. Kuletsa kuyendayenda kwa HMG-CoA reductase kumathandizidwa ndi 90% ya pharmacological ntchito ya rosuvastatin, otsala

10% - ntchito ya metabolites ake.

Mwanjira yosasinthika, pafupifupi 90% ya mlingo wa Rosart umatulutsidwa m'matumbo, ndipo zotsalazo kudzera mu impso. T_1/2 (theka-moyo) - pafupifupi maola 19, ndi kuchuluka kwa mankhwalawa, sikusintha. Kuchuluka kwa madzi a plasma 50 l / h.

Ndi kufatsa komanso kufatsa kwa aimpso, kusintha kwakukuru mu rosuvastatin mu plasma ya magazi kapena N-desmethyl sikuchitika. Kulephera kwakukulu kwa aimpso ndi creatinine chilolezo (CC) osakwana 30 ml / min, zomwe rosuvastatin mu plasma zimawonjezeka katatu, N-desmethyl - 9 times. Odwala pa hemodialysis, kuchuluka kwa rosuvastatin mu plasma kumawonjezera pafupifupi 1/2.

Pamagawo osiyanasiyana a kulephera kwa chiwindi (7 mfundo ndi pansi pa Mwana - Pugh lonse), kuwonjezeka kwa T_1/2 osadziwika. Bakuman T_1/2 rosuvastatin imawonetsedwa kawiri mwa odwala omwe ali ndi vuto la chiwindi pamasamba 8 ndi 9 pamawonekedwe a Mwana-Pugh. Ndi kuphwanya kokwanira kwa chiwindi, palibe zinachitikira ndi kugwiritsa ntchito mankhwalawa.

The pharmacokinetics of rosuvastatin alibe kwambiri mathupi amtundu ndi zaka odwala.

Kuyanjana kwamtundu kumakhudza magawo a Rosartokinetic a Rosart. Plasma AUC (kuchuluka kwathunthu) kwa rosuvastatin ku China ndi Japan ndi kawiri kupirikiza kawiri kuposa kwa azungu ndi North America. C_max ndi AUC kwa Amwenye ndi oimira mpikisano wa Mongoloid mwapakati amawonjezeka ndi 1,3.

Zizindikiro zogwiritsidwa ntchito

• hypertriglyceridemia (mtundu IV malinga ndi Fredrickson) - monga chowonjezera chakudya,
• hypercholesterolemia yoyamba (mtundu IIa malinga ndi Fredrickson), kuphatikizapo heterozygous cholowa hypercholesterolemia, kapena kuphatikiza (chosakanikirana) hyperlipidemia (mtundu IIb malinga ndi Fredrickson) - monga chowonjezera chakudya, zolimbitsa thupi ndi kuchepa thupi,
• homozygous mawonekedwe a cholowa hypercholesterolemia pakalibe chakudya chokwanira ndi mitundu ina ya mankhwala yotsitsa kuchepa kwa ndende ya lipid (kuphatikiza LDL-apheresis) kapena ndi tsankho la munthu payekha pamitundu yotereyi,
• kupewa kwakukulu kwa mtima wamavuto (kugunda kwa mtima, kugunda kwa mtima, kusintha masinthidwe) mwa akulu popanda matenda am'matumbo a matenda a mtima (CHD), koma ndi zofunikira pakukula kwake (msinkhu wa amuna okulirapo zaka 50 ndi azimayi opitirira zaka 60, ndende C - protein protein 2 mg / l ndikukwera pamaso pa zinthu zochepa zowopsa: ochepa matenda oopsa, cholesterol yotsika ya HDL, kumayambiriro kwa matenda a mtima m'mitsempha ya banja, kusuta).

Kuphatikiza apo, Rosart amatchulidwa ngati chowonjezera pakudya kwa odwala omwe akuwonetsedwa kuti amachepetsa cholesterol yonse ndi LDL cholesterol kuti achepetse kupita patsogolo kwa atherosulinosis.

Ma analogi a Rosart, mndandanda wa mankhwala

Mankhwala osokoneza bongo ali ndi mawonekedwe ambiri ofanana ndi mankhwala. Komabe, sizikulimbikitsidwa kuti m'malo mwanu mupeze mankhwala ena nokha (mwachitsanzo, chifukwa cha kusiyana kwa mtengo). Izi zitha kutsogola kuti chida chomwe mwasankha chachipatala chitha kukhala ndi zotsatira zoyipa mthupi, kuwonetsa zoyipa kapena kusakhala ndi zotsatira zoyenera zochizira.

Zofananira za Rosart:

1. Akorta. Uku ndi kutsitsa kwa lipid komwe kumathandizira kuwonjezeka kwa ziwerengero zotsika kwambiri za lipoprotein receptors, zomwe zimapangitsa kutsika kwa kuchuluka kwa cholesterol yoyipa.
2. Crestor. Mapiritsi amawonetsanso momwe zimakhalira chiwindi (pali kuchepa kwa metabolic lipoproteins wapansi ndi mapangidwe a cholesterol). Kuwonjezeka kwa hepatic receptors pama cell membrane kumakwiyitsa catabolism komanso kugwidwa kwa otsika osalimba lipoproteins.

Komanso ma analogu ndi mankhwala osokoneza bongo - Rosucard, Rosistark, Tevastor.

Chofunikira - malangizo a Rosart ogwiritsira ntchito, mtengo ndi kuwunika sikugwira ntchito pa analogues ndipo sangagwiritsidwe ntchito ngati chitsogozo pakugwiritsa ntchito mankhwala omwe ali ndi kapangidwe kake. Nthawi zonse zochizira ziyenera kupangidwa ndi dokotala. Mukasankha Rosart ndi analogue, ndikofunikira kulandira upangiri waluso; mungafunike kusintha njira zamankhwala, mankhwalawa, etc. Osadziyimira nokha!

Ndemanga za madotolo za Rosart ndizosakanikirana. Pazinthu zabwino, njira yothandizira komanso yokhazikika yomwe imakhalapo kwakanthawi ingathe kudziwika. Komabe, zingakhale zovuta kusankha payekha. Odwala amakumananso ndi zovuta pamankhwala, popeza amasiya zakudya zabwino, ngakhale zazing'ono.

Zotsatira zoyipa

Zotsatira zoyipa ndizochepa. Zotsatira zotsatirazi ziyenera kudziwitsidwa kwa dokotala ngati akupitiliza kapena kukulira:

Zotsatira zotsatirazi ndizowopsa. Ngati alipo, muyenera kusiya kumwa Rosart ndi kukaonana ndi dokotala nthawi yomweyo. Zotsatira zoyipa izi zikuphatikiza:

• kupweteka kwa minofu kapena kufooka
• malungo,
• kupweteka pachifuwa
• chikaso cha khungu kapena maso,
• mkodzo wakuda
• kupweteka pamimba kwakumaso,
• nseru
• kutopa kwambiri
• kukha magazi kwachilendo kapena kuvulala
• kusowa kwa chakudya
• zizindikiro ngati chimfine,
• zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda.

Ngati pali vuto lililonse lomwe lingayambitse thupi lanu, muyenera kulankhulana ndi achipatala msanga:

• zotupa
• urticaria,
• kuyabwa,
• kuvutika kupuma kapena kumeza,
• kutupa nkhope, mmero, lilime, milomo, maso, manja, mapazi, matumbo kapena miyendo yotsika,
• kuyamwa
• dzanzi kapena kumva chilala m'm zala ndi zala zakumaso.

Malangizo ogwiritsira ntchito Rosart

Mu malangizo ogwiritsira ntchito, Rosart 10 mg imati mankhwalawa amatengedwa pakamwa popanda kupera isanakwane. Imwani mankhwalawa ndi madzi okwanira, makamaka madzi. Kumwa mapiritsi kulibe chakudya.

Malinga ndi malangizo a Rosart ogwiritsira ntchito, ma milligram 10, mankhwalawa amayenera kumwa ndi osachepera 5 milligram kapena ma milligram 10, ngakhale mlingo waukulu wa ma statin ena atengedwapo kale. Kusankhidwa kwa Mlingo woyamba kumatengera:

• cholesterol mulingo
• chiopsezo cha matenda a mtima kapena sitiroko,
• atengeke zigawo zikuluzikulu za mankhwala.

Ndi muyezo woyambira wa mamiligalamu 5, adokotala amatha kuwirikiza kawiri pa mamiligalamu 10, ndikuwonjezera mpaka mamiligalamu 20 ndi mamiligalamu 40, ngati pangafunike kutero.

Masabata anayi ayenera kudutsa pakati pa kusintha kulikonse. Mlingo wapamwamba wa tsiku ndi tsiku ndi 40 milligrams. Mlingowu umangoperekedwa kwa odwala omwe ali ndi cholesterol yambiri komanso omwe ali ndi chiopsezo chodwala mtima kapena stroko, momwe mulingo wa mamilimita 20 ndi wokwanira kutsitsa cholesterol yamagazi.

Mukamapereka mankhwala kuti muchepetse chiopsezo vuto la mtimasitiroko kapena lawo
mavuto azaumoyo, tsiku lililonse mlingo 20 mg. Mlingo umatha kuchepetsedwa ngati wodwala ali ndi zomwe zili pamndandanda wazolakwa.

Mlingo wa ana a zaka zapakati pa khumi ndi khumi ndi zisanu ndi ziwiri - muyezo woyambira ndi mamiligalamu asanu, mlingo waukulu wa tsiku ndi tsiku ndi 20 mg. Mankhwala ayenera kumwedwa kamodzi patsiku.

Mankhwala a Rosart, mogwirizana ndi malangizo, gwiritsani ntchito 40 mg ali osavomerezeka kwa ana.

Kuchita ndi mankhwala ena

Rosart, pakumwa mankhwala ena, amatha kupweteketsa mawonekedwe osakhudzika:

• Kulandila kwa Rosart ndi Cyclosporine - mankhwala omaliza amalimbikitsa kuwonjezeka kwatsatanetsatane rosuvastatinChifukwa chake, odwala omwe adalandira chithandizo cha cyclosporine ayenera kumwa Rosart muyezo wochepera - osaposa mamililita asanu patsiku.
• Hemofibrozil (Gemfibrozil) - kwambiri kumawonjezera kuyatsidwa kwa ricuvastatin. Chifukwa cha kuchuluka kwa myopathy / rhabdomyolysis, kuphatikiza kwa Rosart ndi Gemfibrozil kuyenera kupewedwa. Mlingo wokwanira sayenera kupitilira mamiligalamu 10 patsiku.
• Mapuloteni oletsa - kuphatikiza kwa Rosart ndi ma proteinase inhibitors osakanikirana ndi ritonavir kumabweretsa zotsatira zosiyanasiyana za rosuvastatin, makamaka makamaka pazinthu zomwe zimapangitsa thupi. Mapuloteni Oletsa Kuphatikiza: lopinavir / ritonavir ndi atazanavir / ritonavir zitha kuwonjezera kukhudzana kwatsatanetsatane wa rosuvastatin mpaka katatu. Pakuphatikiza kumeneku, mlingo wa Rosart suyenera kupitilira mamiligalamu 10 kamodzi patsiku.

Zisonyezero zamankhwala

Ntchito ya Rosart ikuwoneka pazochitika zotsatirazi:

• Kuwonjezeka kwa kuchuluka kwa cholesterol yoyamba, kuphatikiza nthenda yotsimikizika pamtundu, komanso mawonekedwe osakanikirana.

• Anakweza triglycerides m'mwazi.
• Ndi atherosulinosis - kuti muchepetse kupita patsogolo kwa matendawa.
• Kupewera kwa mavuto a ischemic mwa anthu omwe ali ndi matenda amtima komanso a mtima omwe ali pachiwopsezo chachikulu chotukuka: kusuta, kumwa mowa mwauchidakwa, zaka zopitilira 50, cholowa cham'tsogolo, matenda oopsa, kuchuluka kwa mapuloteni a C.

Mankhwalawa amagwiritsidwa ntchito kwambiri pochita zochizira matenda komanso kupewa matenda a mtima. Pakadali pano, mankhwala a Rosart ndi ofanana ndi omwe amaperekedwa kwa odwala ambiri omwe ali ndi cholesterol yayikulu yamagazi yokhala ndi chithandizo chamankhwala osagwira ntchito.

Chithandizo cha zakudya ndi statin

Zakudya zopatsa thanzi pakhungu la hypercholesterolemia siziyenera kukhala zopatsa mphamvu kwambiri - kuchokera 2400 mpaka 2700 zopatsa mphamvu patsiku. Kuphatikiza apo, zakudya sizikhala ndi:

• mafuta, mafuta osuta, komanso zakudya zomwe zimakonzedwa pa grill ndi grill,
• Zakudya zamzitini zokhala ndi mafuta ndi mafuta ambiri,
• mazira - zidutswa zopitilira katatu pa sabata,
• batala
• nyama yambiri ndi nsomba,
• masoseji, masoseji, odzola, zofunafuna,
• mkaka wonse woposa 2.5%, kirimu wowawasa, kirimu,
• nyama yankhumba, nyama yankhumba

• mafuta tchizi,
• Confectionery ndi batala kirimu ndimtundu wowotcha.

Zakudya zomwe zili ndi cholesterol yayikulu zimaphatikizanso masamba ndi zipatso zambiri. Masamba amayenera kudyedwa mwatsopano mumaladi, masamba ophika ndi ophika, masamba otentha. Saladi, ma compotes amakonzedwa kuchokera ku zipatso, ophika ndi uchi. Monga gwero la mapuloteni ophika, tchizi yatsopano yamafuta ochepa komanso nyama yotsika (nkhuku, nyama yamphongo, kalulu, Turkey) amagwiritsidwa ntchito. Kugwiritsa ntchito mbewu za chimanga kumalimbikitsidwa.

Zakudya za tsiku ndi tsiku ziyenera kugawidwa zakudya zingapo - kuyambira zinayi mpaka zisanu ndi chimodzi. Zakudya zimadyedwa mofunda. Muyenera kumwa osachepera malita ndi theka a madzi patsiku, kuwonjezera pa sopo, misuzi, tiyi.

Malamulo a Rosart

Milandu yomwe kugwiritsidwa ntchito kwa zakudya sikupereka zotsatira zomwe zimafunikira ndipo cholesterol imakhalabe pamalo okwera, mapiritsi a Rosart kapena ma statins ena amapatsidwa. Mapiritsi amatha kuledzera nthawi iliyonse yamasiku, mosasamala nthawi yakudya. Mankhwala ayenera kutsukidwa ndi madzi opanda kanthu. Zakudya za hypolipidemic zomwe tafotokozazi ziyenera kutsatiridwa pamankhwala a statin. Mlingo wa mankhwalawa munjira iliyonse amasankhidwa payekha. Monga lamulo, chithandizo cha Rosart chimayamba ndi mlingo wochepa wa 5 mg. Nthawi zina, ndi manambala a cholesterol apamwamba oyambira, mlingo woyambira ungakhale 10 mg wa mankhwalawa. Masabata ochepa pambuyo poyambira chithandizo, ndikulephera kwamankhwala, mlingo umawonjezeka mpaka 20 mg. Kugwiritsa ntchito mankhwala omwe amachepetsa cholesterol nthawi zonse kumakhala kotalika, nthawi zina pamoyo wanu.

Bongo

Zizindikiro za bongo wa rosuvastatin sizinakhazikitsidwe. Mlingo umodzi wambiri wa tsiku ndi tsiku wa Rosart sizikukhudza ma pharmacokinetics.

Chithandizo: kupangika kwa chizindikiro. Kuwongolera zochitika za creatine phosphokinase (CPK) ndi mawonekedwe a chiwindi kuyenera kutsimikiziridwa. Ngati ndi kotheka, njira zimatengedwa kuti zolimbitsa thupi zizigwira ntchito bwino.

Mphamvu ya hemodialysis ndiyokayikitsa.

Malangizo apadera

Chiwopsezo chotenga myopathy, kuphatikiza rhabdomyolysis, chikuchulukitsidwa pamene mukumwa mankhwala a rosuvastatin: cyclosporine, HIV protease inhibitors, kuphatikizapo kuphatikiza kwa ritonavir ndi atazanavir, tipranavir ndi / kapena lopinavir. Chifukwa chake, kuyenera kuganiziridwanso pakusankhidwa kwa njira zina zochiritsira, ndipo ngati kuli kotheka, kugwiritsa ntchito ndalama izi - chithandizo ndi rosuvastatin ziyenera kuyimitsidwa kwakanthawi.

Mukamagwiritsa ntchito Rosart pa 40 mg, ndikofunikira kuwunika pafupipafupi zizindikiro za impso.

Posankha zochita za CPK, ndikofunikira kupatula kukhalapo kwa zinthu zomwe zingaphwanye kudalirika kwa zotsatira, kuphatikizapo zolimbitsa thupi. Odwala omwe ali ndi kuwonjezeka kwakukulu mu ntchito yoyambirira ya CPK amayenera kuwunikanso pambuyo pa masiku 5-7. Pankhani yotsimikizira kuwirikiza kawiri kwa chizolowezi cha ntchito ya KFK, kugwiritsa ntchito mankhwalawa kumatsutsana.

Chisamaliro chapadera chiyenera kuthandizidwa popereka mankhwala kwa Rosart kwa odwala omwe ali pachiwopsezo chotukula myopathy kapena rhabdomyolysis, kuwunika mosamala kuchuluka kwa mapindu omwe akuyembekezeka komanso zoopsa zomwe zingachitike chifukwa cha mankhwala. Zowona zamankhwala ziyenera kuperekedwa kwa gulu ili la odwala nthawi yonse yomwe akuchira. Simungayambe kumwa mapiritsi ndi ntchito yoyamba ya CPK nthawi 5 kuposa malire apamwamba.

Dotolo ayenera kudziwitsa wodwalayo za kupezeka kwa kupweteka kwa minyewa, malaise, kutentha thupi, kufooka kwa minofu kapena kukokana panthawi ya mankhwala, komanso kufunika kofunsa malangizo kuchipatala msanga. Kukula kwakukulu kwa ntchito za KFK kapena zizindikiro za minofu, mankhwalawa ayenera kusiyidwa. Ndi kutha kwa zizindikiro ndi kubwezeretsanso kwa ntchito ya KFK, ndikotheka kutumikiranso mankhwalawo mumaling'ono ang'onoang'ono.

1-2 kawiri pamwezi, mbiri ya lipid iyenera kuyang'aniridwa ndi mlingo wa Rosart kusintha malinga ndi zotsatira zake.

Pokhala ndi mbiri yodwala matenda a chiwindi komanso odwala omwe amamwa mowa mopitirira muyeso, tikulimbikitsidwa kuti isanayambike mankhwala ndikatha miyezi itatu yogwiritsa ntchito mankhwalawa, Zizindikiro zokhudzana ndi chiwindi zimatsimikizika. Ngati ntchito ya hepatic michere mu magazi seramu ndi 3 kuchulukitsa kuposa malire apamwamba, muyenera kuchepetsa mlingo kapena kusiya kumwa Rosart.

Popeza kuphatikiza kwa HIV proteinase inhibitors ndi ritonavir kumapangitsa kuchuluka kwa dongosolo la rosuvastatin, kuchepa kwa magazi lipid ndende kuyenera kuyang'aniridwa mosamala, kuwonjezereka kwa kuchuluka kwa rosuvastatin m'madzi a m'magazi kuyenera kuganiziridwanso kumayambiriro kwa chithandizo komanso pakukula kwa mlingo wa mankhwalawa, ndipo kusintha koyenera kwa mankhwala kuyenera kuchitika.

Kutseka kwa Rosart kumafunikira ngati pakukayikira matenda am'mapapo, omwe angayambitse kufupika, chifuwa chosabereka, kufooka, kuchepa thupi komanso kutentha thupi.

Mimba komanso kuyamwa

Malinga ndi malangizo, Rosart amatsutsana mu nthawi ya gestation ndi kuyamwitsa.

Kukhazikitsidwa kwa mankhwalawa kwa akazi azaka zoyenera kubereka kuyenera kuchitidwa pokhapokha ngati akugwiritsa ntchito njira zodalirika zakulera.

Wodwala ayenera kudziwitsidwa za chiopsezo chotheka kwa mwana wosabadwa ngati ali ndi pakati pa nthawi ya chithandizo.

Ngati kuli kotheka kutenga Rosart panthawi yoyamwitsa, kuyamwitsa kuyenera kuyimitsidwa.

Ndi mkhutu aimpso ntchito

Kugwiritsa ntchito Rosart kumapangidwa mulingo uliwonse wa Mlingo wolephera kwambiri waimpso ndi CC zosakwana 30 ml / min, pa 40 mg - ndi CC kuchokera 30 mpaka 60 ml / min.

Ndi kufatsa kochepa kapena kosapindika kwa kulephera kwa impso, kusintha kwa mankhwalawa sikofunikira, mlingo woyambirira ndi CC wochepera 60 ml / min uyenera kukhala 5 mg.

Ndi chiwindi ntchito

Kusintha kwa mlingo wa rosuvastatin sikofunikira kwa chiwindi kulephera kwa 7 mfundo kapena kutsika pamlingo wa Mwana-Pugh, wokhala ndi mfundo za 8 ndi 9 pamlingo wa Mwana-Pugh, kuikidwa kuyenera kuchitika pambuyo poyeserera koyambirira kwa ntchito ya impso.

Zochitika ndi Rosart mu kufooka kwa chiwindi pamwamba pa mfundo 9 pamakwerero a Mwana-Pugh sizikupezeka.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito nthawi yomweyo Rosart:

• mankhwala omwe amalepheretsa mapuloteni, omwe amagwiritsidwa ntchito ndi rosuvastatin, kuwonjezera mwayi wopanga myopathy,
• cyclosporine imayambitsa kuwonjezeka kwakukulu kwa rosuvastatin, ndikuwonjezera kuchuluka kwake mu plasma nthawi 11,
• erythromycin imawonjezera C_max ndi 30% ndi kuchepa kwa AUC ya rosuvastatin ndi 20%,
• warfarin ndi ma anticoagulants ena osadziwika angayambitse kusinthasintha kwa MHO (chiwembu chapadziko lonse chomwe chimagwiritsidwa ntchito kudziwa chizindikiro cha kuphatikizika kwa magazi): kumayambiriro kwa kugwiritsidwa ntchito komanso kuwonjezeka kwa mlingo wa rosuvastatin, kuwonjezeka kwa MHO, ndipo mukathetse kapena kuchepetsa mlingo wa rosuvastatin, kuchepa kwa INR, chifukwa chake kuwunikira MHO
• mankhwala ochepetsa lipid, kuphatikiza gemfibrozil, amachititsa kuchuluka kwa AUC ndi C_max 2 times rosuvastatin,
• Maantacid okhala ndi aluminiyamu ndi magnesium hydroxide amachepetsa plasma ndende ya mankhwalawa 2,
• kulera kwapakamwa kumawonjezera AUC ya ethinyl estradiol ndi 26% ndi norchedrel ndi 34%,
• fluconazole, ketoconazole ndi mankhwala ena omwe amalepheretsa ma isoenzymes CYP2A6, CYP3A4 ndi CYP2C9 sachititsa kuti pakhale kulumikizana kwakukulu,
• ezetimibe (pa mlingo wa 10 mg) mwa odwala omwe ali ndi hypercholesterolemia amawonjezera AUC ya rosuvastatin (pa 10 mg) pofika nthawi ya 1.2, kukulitsa kwa zovuta zovuta,
• HIV protease inhibitors imatha kupangitsa chiwopsezo chowonjezereka cha rosuvastatin,
• digoxin sayambitsa kudwala kwakukulu.

Pogwiritsa ntchito rosuvastatin, muyenera kufunsa dokotala ngati pakufunika kuti muphatikize ndi mankhwala ena.

Zofanizira za Rosart ndi izi: Akorta, Actalipid, Vasilip, Lipostat, Mertenil, Medostatin, Zokor, Simvakol, Rosuvastatin, Krestor, Rosucard, Rosistark, Rosulip, Torvazin, Tevastor, Kholetar.

Ndemanga za Rosart

Ndemanga za Rosarte ndizabwino. Odwala akuwonetsa njira yothanirana mwachangu, kutsindika kuti cholesterol imatsika ndikuyamba mapiritsi, koma kugwiritsa ntchito mankhwalawa ndikofunikira kuti mfundo zake zizikhala zofanana moyenera.

Odwala ena amachenjeza kuti kusintha kosautsa komwe kumayamwa ndi kuyamwa, kutsitsa magazi, kuoneka ngati mutu ndi kupweteka kwam'mimba ndikotheka. Koma mwambiri, zimadziwika kuti Rosart imapereka zotsatira zoyipa zochepa poyerekeza ndi mankhwala ena ofanana. Kwa ambiri, mtengo wa mankhwalawo ndiwokwera kwambiri.

Mtengo wa Rosart m'masitolo ogulitsa mankhwala

Mtengo wa Rosart kutengera mtundu:

• Rosart 5 mg pakiti iliyonse ya mapiritsi 30 - kuchokera ku ma ruble 400, mapiritsi 90 - kuchokera ku ruble 1009,
• Rosart 10 mg pakiti iliyonse ya mapiritsi 30 - kuchokera ma ruble 569, mapiritsi 90 - kuchokera ku ruble 1297,
• Rosart 20 mg pakiti iliyonse ya mapiritsi 30 - kuchokera 754 ma ruble, mapiritsi 90 - kuchokera 1954 ma ruble,
• Rosart 40 mg pakiti iliyonse ya mapiritsi 30 - kuchokera ku ma ruble a 1038, mapiritsi 90 - kuchokera ku ruble 2580.

Njira zogwiritsira ntchito

Kufotokozera kwa kagwiritsidwe ntchito ka mankhwala kuchokera ku cholesterol yayitali kwambiri ndi gawo lalikulu la rosuvastatin - Rosart:

• Kuyamba kwa mankhwala osokoneza bongo ndi mankhwala a Rosart kumayamba ndi zakudya za cholesterol, zomwe zimagwirizana ndi njira yonse yothandizira ndi ma statins,
• Dokotala yemwe akupezekapo akufotokozerani momwe angatenge Rosart, komanso mlingo wosankhidwa payekha ndi dotolo molingana ndi zizindikiro za biochemistry yokhala ndi lipid spectrum (lipograms),
• Piritsi ya Rosart iyenera kukhala yoledzera kwathunthu osatafuna, ndikutsukidwa ndi madzi ambiri. Palibenso chifukwa chomangirira mankhwalawo ku chakudya, muyenera kungodziwa nthawi yeniyeni yomwe kudya tsiku lililonse. Ndikulimbikitsidwa kutenga Rosart madzulo asanagone, ndipo izi zimachitika chifukwa cha bioprocesses mthupi la munthu, komanso kuyambira nthawi yogwira mafuta a cell cholesterol.
• Mlingo woyamba wa Rosart wa mamiligoramu 5.0 kapena 10,0, kamodzi tsiku lililonse,
• Dokotala wokhazikika ndi okhayo amene angachulukitse mlingo kapena amwe mankhwalawo ndi analogue, koma osapitirira mwezi umodzi atalandira chithandizo cha Rosart. Kuchulukitsa kwa mankhwalawa kumachitika pokhapokha potsatira zotsatira za kufufuza zamankhwala am'magazi komanso ngati mlingo wocheperako sugwira ntchito,
• Mlingo wambiri patsiku - mamiligalamu 40.0, amawonetsedwa kwa odwala omwe ali ndi chiopsezo chopanga matenda a mtima kapena pathologies a kayendedwe ka magazi, koma pokhapokha ngati mankhwala a Rosart omwe ali ndi mulingo wa mamilimita 20.0 samabweretsa kuchepa kwa index cholesterol (ndi hypercholesterolemia ya genetic kapena etiology ya mabanja). Kuchiza ndi mlingo wa Rosart mu mamiligalamu 40.0 kumachitika kokha mu chipatala moyang'aniridwa ndi dokotala,
• Mlingo wokwanira umaperekedwanso kwa odwala omwe ali ndi mawonekedwe oopsa a systemic atherosulinosis,
• Ndi mankhwala omwe ali ndi mlingo wa mamiligamu 10,0, yang'anani cholesterol index ndi ma transaminase inde - atatha masiku 14 a makonzedwe,
• Ndi pang'ono pang'ono kakulidwe ka matenda a impso, palibe chifukwa chosinthira mlingo, ndipo mankhwalawa sasinthidwa atakalamba - okulirapo kuposa zaka 70, koma chithandizo chiyenera kuyambitsidwa ndi ma milligram a 5.0 patsiku,
• Pa mlingo waukulu wa mamiligalamu 40.0 patsiku, nthawi zonse muziyang'anira cholembera cha phosphokinase,
• Ngati wodwala ali ndi mbiri ya myopathy, ndiye kuti chithandizo chikuyenera kuchitika ndi mankhwala a Rosart pa mamiligoramu 5.0,
• Odwala omwe ali ndi ma pathologies a maselo a chiwindi malinga ndi kukula kwa Mwana-Pugh, mpaka mfundo 7.0, asanaikidwe kuti apange kafukufuku wambiri komanso osapereka mankhwala opitilira ma milligram a 5.0 patsiku.

Mulingo waukulu wa mankhwala opezeka piritsi, umakhala wolakwika kwambiri mthupi kuchokera ku kayendetsedwe kake.

Zisonyezero zakudikirira

Rosart ndi mankhwala zochizira matenda:

• Mtundu woyambirira wa heterozygous wosabadwa komanso mtundu wa hypercholesterolemia (mtundu wa 2A malinga ndi Fredrickson) kuwonjezera pa zakudya za cholesterol, komanso hypercholesterolemia yopanda genetic, kuphatikiza zakudya, kupsinjika kwa thupi, komanso kunenepa.
• Ndi homozygous mtundu wa hypercholesterolemia wophatikiza ndi zakudya, ngati chakudya chokha sichithandiza kutsika cholesterol index,
• Mtundu Wosakanikirana wa hyperlipidemia (mtundu wa 2B malinga ndi Fredrickson), wophatikiza mafuta a cholesterol,
• Matenda a dysbetalipoproteinemia (mtundu 3 malinga ndi Fredrickson), palimodzi ndi zakudya,
• The etiology ya banja ya hypertriglyceridemia (Fredrickson mtundu 4) monga chowonjezera chachikulu chakudya cha cholesterol,
• Kuletsa kupitirira kwa systemic atherosulinosis kuphatikiza ndi zakudya, zolimbitsa thupi, komanso kuchepa thupi.

Kupewa koyambirira kwa mankhwala a Rosart kumachitika ndi zotere:

• Ndi mtundu wamtundu wa kusinthanso,
• Cardiac ischemia,
• Myocardial infaration ndi matenda a mtima,
• Ndi msinkhu wa thupi la amuna zaka 50 ndi zaka 55 mwa akazi,
• Kuchuluka kwa mapuloteni a C
• Ndi matenda oopsa
• Ndi index yochepetsedwa ya cholesterol ya HDL,
• Ndi chikonga komanso mankhwala osokoneza bongo.

Kodi Ndingatani Kuti Ndimugwiritse Ntchito Rosart?

Malangizo ogwiritsira ntchito Rosart akuphatikizira mafotokozedwe a milandu omwe mankhwalawo sangathe kufotokozedwera. Rosart mu Mlingo wa 5, 10, 20 mg wodziwika milandu:

1. Atsikana achichepere omwe sagwiritsa ntchito njira zodalirika popewa kutenga pakati.
2. Matenda a chiwindi.
3. Zokwera milingo ya hepatic transaminases (michere) yopanda tanthauzo.
4. Matenda a impso, yodziwika ndi kuwonongeka kwakukulu kwa ntchito.
5. Mitundu ina yamatenda a metabolic.
6. Ana osakwana zaka 18.
7. Njira ya myopathic.
8. Nthawi ya mankhwala ndi cyclosporine.
9. Nthawi ya bere ndi kuyamwitsa.

Mapiritsi a Rosart okhala ndi 40 mg a Rosuvastatin amadziwikanso ndi matenda omwe ali pamwambapa ndi zikhalidwe zathupi. Kuphatikiza apo, Rosart 40 mg siingagwiritsidwe ntchito ndi:

1. Chithandizo cha mankhwala okhudzana ndi mafupa.
2. Matenda a chithokomiro (hypothyroidism).
3. Mowa.
4. Myopathies m'mbuyomu idachitika chifukwa chogwiritsa ntchito ma statins ndi ma fiber.
5. Zinthu zomwe zingayambitse kuchuluka kwa plasma ndende ya rosuvastatin.
6. Kuchotsedwa kwa cholowa chifukwa cha matenda amthupi.
7. Kukhala wa liwiro la a Mongoloid.

Mimba komanso kudyetsa mwana

Popeza Rosart amatha kudutsa chotchinga, kugwiritsa ntchito mankhwalawa panthawi ya gestation kumatsutsana.

Mimba ikachitika munthawi ya Rosart, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.

Popereka mankhwala a Rosuvastatin kwa amayi omwe ali ndi zaka zakubadwa osagwiritsa ntchito njira zodalirika zakulera komanso omwe ali ndi chiwopsezo chachikulu cha kutenga pakati, ndikofunikira kufotokozera zovuta za mankhwala a Rosuvastatin pa mwana wosabadwayo. Kutha kwa Rosuvastatin kudutsa mkaka wa m'mawere sikunachitikebe, koma sikunaphatikizidwe. Chifukwa chake, Rosart sagwiritsidwa ntchito poyamwitsa.

Gwiritsani ntchito Rosart mosamala

Kuphatikiza apo, pali zinthu zina zomwe Rosart imagwiritsidwa ntchito, koma mosamala. Mapiritsi okhala ndi 5, 10 ndi 20 mg wa Rosuvastatin amalembedwa mosamala mu:

1. Kuopsa kwa myopathy.
2. Oimira mtundu wa Mongoloid.
3. Zoposa zaka 70.
4. Hypothyroidism
5. Kuwonongeka kwa khungu kwa mapangidwe a myopathic njira.
6. Kukhalapo kwa zochitika komwe chizindikiro cha Rosuvastatin mu madzi am'magazi chitha kuchuluka kwambiri.

Mukasankha Rosart, munthu ayenera kuganizira mosamala ma contraindication omwe alipo kuti aletse kukula kosakhudzidwa kuchokera ku ziwalo zofunika komanso machitidwe. Zotsatira zoyipa ndizodziwika ndi ma statins onse komanso mankhwala omwe ali ndi rosuvastatin ndiwonso.

Zotsatira zoyipa

• Mitsempha yam'mimba ndi psyche: kupweteka mutu, nkhawa, kusowa tulo, kukhumudwitsa, chizungulire, paresthesia, chitukuko cha asthenic syndrome.

• Matumbo dongosolo: kudzimbidwa, pafupipafupi zotayirira, kupweteka kwam'mimba, kupindika, nseru, kutentha kwa mtima, kutupa kwa kapamba, chiwindi.
• Metabolism: matenda ashuga.
• Machitidwe opumira: mphuno yam'mimba, pharyngitis, kutupa kwa sinus, chifuwa, mphumu la bronchial, kulephera kupuma.
• Musculoskeletal system: myalgia (kupweteka kwa minofu), kamvekedwe ka minofu, kupweteka kwa msana ndi kumbuyo, kufooka kwa mtima.
• Thupi lawo siligwirizana limatha kupezeka ndi zotupa pakhungu, ming'oma, kutupa kwa nkhope ndi khosi, kukulira kwa anaphylaxis.
• Zotsatira zina zosafunikira.

Monga lamulo, kuwoneka kosakhudzidwa kosakhudzana mwachindunji ndi kuchuluka kwa mankhwalawa. Nthawi zambiri ndikusintha kwa mlingo, Zizindikiro zimachepa kapena kutha kwathunthu.

Komabe, ndi kukulira kwa zizindikiro za myopathy ndi thupi lawo siligwirizana, muyenera kusiya kugwiritsa ntchito Rosart ndikupita kuchipatala.

Dokotala adzalembera njira zoyenera ndi mankhwala kuti athetse vuto losafunikira ndikusankha m'malo mwake.

Mitu ya mankhwalawa

Mu msika wogulitsa mankhwala ku Russia mumapezeka mankhwala ambiri okhala ndi rosuvastatin. Zofanizira za Rosart zimapangidwa ndi makampani onse aku Russia ndi akunja. Mankhwalawa ndi otchuka kwambiri: Rosucard, Rosulip, Rosuvastain-SZ, Roxer, Rosufast, Rustor, Rosustark, Tevastor, Mertenil. Mankhwalawa onsewa ndimakopi opangidwanso - majeniki. Mankhwala oyamba omwe ali ndi Rosuvastatin ndi Krestor, opangidwa ku UK ndi Astra Zeneca. Mtengo wamankhwala omwe ali ndi rosuvastatin ndiwosiyana ndipo zimatengera mtengo wopanga, mtundu ndi kuchuluka kwa mapiritsi omwe ali phukusi.

Mukamasankha mankhwala ochepetsa cholesterol yamagazi, muyenera kuwongoleredwa, choyambirira, ndi malangizo a dokotala.

Ndi zoletsedwa kupereka mankhwala a statin nokha!

Ndi dokotala yekhayo amene angasankhe molondola mankhwala oyenera ndi mlingo wake, poganizira zomwe zikuwonetsa ndi contraindication. Ndikofunikira kuti muuzeko dokotala zamankhwala onse omwe mumamwa kuti mupewe kuyanjana ndi mankhwala mosafunikira.

Mapiritsi a Rosart cholesterol: ndemanga ndi zisonyezo zogwiritsidwa ntchito

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

Chimodzi mwazinthu zofunika komanso zofunika kwambiri kwa thupi la munthu ndi cholesterol. Ndikofunikira kwambiri kuti zisonyezo zake zigwirizane ndi chizolowezi, chifukwa kuchepa kapena kupindulitsa kwambiri kumabweretsa thanzi. Kuwonjezeka kwa LDL m'magazi kumathandizira kuti ma atherosulinosis awoneke, omwe amadziwika ndi kusintha kwa mitsempha yamagazi komanso kuchepa kwawo.

Pakadali pano, maziko othandizira matenda osiyanasiyana a mtima ndi mankhwala osokoneza bongo omwe amaphatikizidwa ndi kayendedwe ka cholesterol metabolism m'thupi la munthu. Pali mitundu yambiri. Chimodzi mwazida zapamwamba kwambiri, zogwira ntchito komanso zotetezeka za lipid ndi Rosart.

Pakugwiritsa ntchito bwino, Rosart amakhala patsogolo pakati pa gulu la ma statins, kutsitsa bwino zizindikiro za "zoyipa" (low lowens lipoproteins) ndikukulitsa kuchuluka kwa cholesterol "yabwino".

Kwa ma statins, makamaka, Rosart, mitundu yotsatirayi ya zochizira ndi chikhalidwe:

• Imalepheretsa zochita za ma enzyme omwe amatenga nawo gawo pakuphatikizika kwa cholesterol mu hepatocytes. Chifukwa cha izi, kuchepa kwakukulu kwa cholesterol ya plasma kumaonekera,
• Zimathandizira kuchepetsa LDL mwa odwala omwe ali ndi cholowa cholowa hypercholisterinemia. Ichi ndi katundu wofunikira wama statins, chifukwa mankhwalawa samachiritsidwa pogwiritsa ntchito mankhwala am'magulu ena opanga mankhwala,
• Imakhala ndi phindu pa ntchito ya mtima ndi mtima, imachepetsa kwambiri zovuta pamagwiritsidwe ake ndi ma pathologies omwe amagwirizana nawo,
• Kugwiritsa ntchito kwa mankhwalawa kumabweretsa kuchepa kwa cholesterol ndi oposa 30%, ndipo LDL - mpaka 50%,
• Kuchulukitsa HDL mu plasma,
• Simalipira mawonekedwe a neoplasms ndipo alibe mphamvu yotulutsa thupi.

Mtengo wa Rosart

Kusiyana kwa mtengo wamankhwala a Rosart cholesterol kumatengera zomwe zili mwa iwo (mg) ndi kuchuluka kwa mapiritsi omwewo.

Mtengo wa Rosart 10 milligrams a 30 zidutswa mu phukusi uzikhala pafupifupi ma ruble 509, koma mtengo wa Rosart wokhala ndi zinthu zomwezo zogwira ntchito, koma zidutswa 90 mu phukusi ndizokwera kawiri - pafupifupi 1190 rubles.

Rosart 20 mg 90 zidutswa pa paketi iliyonse pama ruble 1,500.

Mutha kugula mankhwala m'mafakisoni mwa mankhwala. Tiyenera kukumbukira kuti musanayambe kulandira chithandizo, muyenera kupita ku katswiri, kukafufuza kwathunthu ndikukhala ndi moyo wathanzi kuti mukwaniritse bwino.

Momwe mungatenge akatswiri a statins anganene mu kanema munkhaniyi.

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

Kuchita ndi mankhwala ena

• Mankhwala a Antacid amachepetsa kuchuluka kwa Rosart m'magazi ndi 35.0%,
• Mukamatengedwa ndi Digoxin, pamakhala chiopsezo chopanga ma pathologies, myopathy ndi rhabdomyolysis,
• Maantibayotiki am'magazi a erythromycin ndi gulu la ufafanuzi wa ascithromycin, amawonjezera plasma ndende ya mankhwala a Rosart mu kapangidwe ka magazi a plasma,
• Mankhwalawa cyclosporin. Kuchuluka kwa rosuvastatin kumakwera koposa maulendo 7,
• Mukamagwiritsa ntchito Rosart ndi ma inhibitors, kuchuluka kwa rosuvastatin kumawonjezeka, komwe kumakhala kowala ndi kukula kwa myopathy,
• Mukamachitira ndi warfavir, ndikofunikira kuyang'anira nthawi ya prothrombin,
• Niacin wa mankhwalawa amadzetsa chiopsezo cha rhabdomyolysis.

Malangizo oyang'anira

Mankhwala a Rosart amangoperekedwa ndi adokotala omwe amapita malinga ndi zotsatira za zida zothandizira.

Asanayambe chithandizo, odwala onse ayenera kudziwitsidwa ndi dokotala za zovuta zomwe zingakhale ndi kumwa mankhwala a Rosart.

Kugogomezera kwakukulu kuyenera kuyikidwa pa kuthekera kwa kupweteka kwa minofu ndikukula kwa matenda a myopathy:

• Pa chithandizo cha Rosart pamlingo wa 20,0 ndi 40.0 mamililita a yogwira pophika, zochitika za cholefine phosphokinase index m'madzi a plasma zimayang'aniridwa nthawi zonse, komanso ntchito ya minofu ya minofu ndi mafupa a impso. Kuwonjezeka kwa ntchito ya creatine phosphokinase ndi chizindikiro cha kukula kwa matenda a myopathy mu minofu. Mankhwalawa ayenera kuyimitsidwa, kapena mlingo wake usinthidwe pang'ono,
• Ndi kukula kulikonse kwa ululu m'minyewa kapena mafupa, wodwalayo ayenera kuwona dokotala. Nthawi zambiri kuchokera pakumwa mankhwala a Rosart, kufooka kwa minofu kumachitika, ndipo autoantibodies amapangidwa mwa iwo,
• Ngati mayiyo anapezeka kuti ali ndi pakati pa mankhwala a Rosart ndi mankhwalawo, ndiye kuti mankhwalawo ayenera kuthetsedwa mwachangu, ndipo mayi woyembekezera ayenera kuyesedwa, ndipo mwana wosabadwayo amayenera kuwunikidwa
• Ngati mankhwala osokoneza bongo a Rosart apezeka, ndiye muyenera kufunsa dokotala. Dokotala adzakuwuzani kuti mutha kugwiritsa ntchito matenda oopsa; hemodialysis ngati mankhwala osokoneza bongo a Rosart sagwira ntchito.

Zofanizira zapakhomo

Zofanizira zakunja

Pomaliza

Kugwiritsa ntchito mankhwala a Rosart kuti muchepetse cholesterol index kumaloledwa kokha ndikusankhidwa kwa dokotala wokhazikika. Kusintha mlingo nokha ndikuloledwa.

Ngati mutsatira malingaliro onse a dokotala ndikutsatira zakudya, ndiye kuti mufulumizire njira yochizira.

Kuchiza kumachitika ndikuwunikira kolesterol yothandizira.

Vitaliy, wazaka 60: Ndakhala ndikutenga Rosart pafupifupi chaka chimodzi. Cholesterol imatsika mwanjira yokhazikika mutamwa mapiritsi mwezi umodzi.

Adotolo adandilimbikitsanso kumwa mankhwalawo m'njira yogawa, chifukwa ndiyenera kuyang'anira cholesterol yanga yabwino.

Ndisanamwa mankhwalawa, ndidadutsa chakudya chama hypolipidemic, koma sikuti kutsitsa kwa cholesterol index.

Ndi kuikidwa kwa Rosart ndi zakudya zokha, ndidatha kutsitsa, ndipo tsopano ndikhazikitse cholesterol yanga yabwino. Zotsatira zoyipa zinali kumayambiriro kwa maphunziro a mankhwalawa mawonekedwe a zotupa pakhungu ndi matumbo kukhumudwa, koma pambuyo pa milungu iwiri yoyendetsa adadutsa.

Valentine, wazaka 51: Kuphatikiza pa zakudyazo, adotolo adandiwuza Rosart chifukwa cha kunenepa kwambiri komanso cholesterol yambiri (9.0 mmol / L).

Kwa miyezi itatu nditamwa mankhwalawa komanso zakudya, ndinakwanitsa kutaya ma kilogalamu 12, ndipo cholesterol inatsika mpaka 6.0 mmol / L.

Ndine wokhutira ndi izi, koma ndikofunikira kupitiliza mankhwala ndi mapiritsi a Rosart, mpaka cholesterol yanga ikhazikike. Sindinamve zovuta zina zilizonse kuchokera ku mankhwalawa panthawi yanthawi yamankhwala.