Kugwiritsa ntchito metformin: kuchokera ku matenda ashuga, ukalamba ndipo osati ...

Metformin ndi chinthu chamgulu. khwawa, momwe amagwirira ntchito akuwonekera chifukwa cha kulepheretsa kwa gluconeogeneis m'chiwindi, kumachepetsa kuyamwa kwa m'matumbo, kumapangitsanso njira yogwiritsira ntchito zotumphukira zama glucose, kumakulitsa kuchuluka kwa minyewa kumva. Zisakhudze njira ya insulin katulutsidwe ka beta maselo a kapamba, sizimawonetsa kuwonetsa kwa hypoglycemic. Zotsatira zake, imayima hyperinsulinemia, chomwe ndichinthu chofunikira kwambiri chothandizira kukulitsa thupi komanso kupita patsogolo kwamavuto amitsempha. Mothandizidwa ndi iye, thupi limakhazikika kapena kuchepa.

Chida chimachepetsa zomwe zili triglyceridesndi ma linoproteinkachulukidwe kakang'ono. Imachepetsa kuchepa kwa mafuta oxidation, amalepheretsa kupanga ma free acid acid. Mphamvu yake ya fibrinolytic imadziwika, kuletsa PAI-1 ndi t-PA.

Mankhwala amaletsa kukula kwa kufalikira kwa minofu yosalala ya khoma la mtima. Zabwino pa boma la mtima dongosolo, kumalepheretsa chitukuko matenda ashuga angiopathy.

Pharmacokinetics ndi pharmacodynamics

Metformin itagwiritsidwa pakamwa, kupindika kwakukulu kumawonedwa mu plasma pambuyo maola 2,5. Mwa anthu omwe amalandira mankhwalawa muyezo waukulu, zomwe zili kwambiri pazomwe zimagwira mu plasma sizinali zapamwamba kuposa 4 μg / ml

Mafuta a yogwira pophika ayimitsa maola 6 mutatha kukhazikitsa. Zotsatira zake, ndende ya plasma imachepa. Ngati wodwala amatenga Mlingo wa mankhwalawa, ndiye kuti pambuyo pa masiku awiri osasunthika okhazikika omwe ali ndi chidwi ndi gawo la 1 μg / ml kapena kuchepera kumawonekera plasma.

Ngati mankhwalawa amatengedwa panthawi ya chakudya, ndiye kuti kuyamwa kwazomwe zimagwira kumachepa. Amadziunjikira makamaka m'makoma a chimbudzi chimbudzi.

Hafu ya moyo wake ndi pafupifupi maola 6.5. Mlingo wa bioavailability mwa anthu athanzi ndi 50-60%. Ndi mapuloteni a plasma, ubale wake ndiwofanana. Pafupifupi 20-30% ya mlingo amatuluka kudzera mu impso.

Zizindikiro Metformin

Zizindikiro zotsatirazi zakugwiritsa ntchito Metformin zimatsimikiziridwa:

• lembani 1 ndi matenda ashuga 2.

Mankhwalawa amalembedwa ngati njira yowonjezerapo yothandizila ndi mankhwala a insulin, komanso mankhwala ena othandizira matenda a shuga. Amatinso ngati monotherapy.

Chidachi chimagwiritsidwanso ntchito, koma izi zitha kuchitika moyang'aniridwa ndi dokotala.

Contraindication

Otsutsa otsatirawa ogwiritsira ntchito mankhwala Metformin atsimikiza:

• wodwala mpaka zaka 15,
• kuchuluka kwa chidwi ndi zomwe zimapangidwira kapena zina za mankhwala,
• matenda oopsa a impso (kukanika, kulephera),
• matenda a shuga
• matenda ashuga ketoacidosis,
• kusowa kwamadzi (ngati kusanza kosalekeza komanso)
• odwala matenda ashuga phazi
• mu mawonekedwe
• kuchepa madzi m'thupi, matenda opatsirana opatsirana, mantha komanso zinthu zina zomwe zingayambitse matenda aimpso.
• adrenal kusowa
• kulephera kwa chiwindi,
• Zakudya zomwe munthu samadya zosaposa 1000 kcal patsiku,
• lactic acidosis,
• uchidakwa wambiri,
• matenda omwe wodwala amakhala ndi minofu hypoxia,
• intravenous kapena intra-arterial oyang'anira a radiopaque mankhwala momwe mumakhala
• poyizoni wa mowa,
• ndi nthawi.

Zotsatira zoyipa

Nthawi zambiri, mukamamwa mankhwalawo, zotsatira zoyipa m'ntchito zake zimawonetsedwa zida zam'mimba: nseru, kusanza, kupweteka kwam'mimba, kuwonjezeka, kulawa kwazitsulo mkamwa. Monga lamulo, izi zimachitika nthawi yoyamba kumwa mankhwalawa. Nthawi zambiri, amachoka okha ndikugwiritsa ntchito mankhwalawa.

Ngati munthu ali ndi chidwi chachikulu ndi mankhwalawa, kukhazikika kwa erythema ndikotheka, koma izi zimachitika nthawi zina. Ndi kukula kwa osowa mbali zotsatira - erythema - - ndikofunikira kuletsa phwando.

Ndi chithandizo chakanthawi, odwala ena amayamba kuwonjezeka chifukwa cha mayamwidwe. Zotsatira zake, mulingo wake mu seramu umachepa, zomwe zimatha kubweretsa kuphwanya hematopoiesis ndi chitukuko megaloblastic anemia.

Mapiritsi a Metformin, malangizo (njira ndi mulingo)

Ndikofunikira kumeza miyala yonse ndikuwamwa ndi madzi ambiri. Amamwa mankhwalawo atatha kudya. Ngati nkovuta kwa munthu kumeza piritsi 850 mg, itha kugawidwa magawo awiri, omwe amatengedwa nthawi yomweyo, wina pambuyo pa mnzake. Poyamba, mlingo wa 1000 mg patsiku amatengedwa, mlingo uwu uyenera kugawidwa pawiri kapena katatu kuti mupewe mavuto. Pambuyo masiku 10-15, mlingo umakulitsidwa pang'onopang'ono. Kutalika kwakukulu kovomerezeka kwa 3000 mg ya mankhwala patsiku.

Ngati achikulire amatenga Metformin, ayenera kuyang'anira impso zawo nthawi zonse. Zochizira zathunthu zitha kupezeka pambuyo pa masabata awiri atayamba chithandizo.

Ngati ndi kotheka, yambani kumwa Metformin mutamwa mankhwala ena a hypoglycemic, muyenera kusiya kaye kumwa mankhwalawa, kenako nkumayamba kumwa Metformin muyezo womwe umanenedwa.

Ngati wodwalayo aphatikiza insulin ndi Metformin, ndiye kuti m'masiku angapo oyamba simuyenera kusintha mtundu wa insulin. Komanso, mlingo wa insulin ungachepetse pang'onopang'ono moyang'aniridwa ndi dokotala.

Mayendedwe Metformin Richter

Dokotala amakhazikitsa muyeso wa mankhwalawo, zimatengera shuga wamagazi a wodwalayo. Mukamamwa mapiritsi a 0,5 g, muyeso woyamba ndi 0,5-1 g patsiku. Kupitilira apo, mankhwalawa akhoza kuchuluka ngati pakufunika. Mlingo wapamwamba kwambiri patsiku ndi 3 g.

Mukamamwa mapiritsi a 0,85 g, muyeso woyamba ndi 0,85 g patsiku. Kupitilira apo, ngati kuli kotheka, kuwonjezera. Mlingo wapamwamba kwambiri ndi 2.55 g patsiku.

Bongo

Ngati mankhwala osokoneza bongo amakula, zotsatira zoyipa zimachitika, ndichifukwa chake mapiritsi amalimbikitsidwa kuti azikumwa pokhapokha muyezo womwe umaperekedwa. Mukamamwa metformin mu mlingo wa 85 g, nkhani ya overdose inalembedwa, chifukwa cha zomwe lactic acidosis inayamba, pomwe kusanza, nseru, kupweteka kwa minofu, kutsekula m'mimba, ndi kupweteka kwam'mimba zimadziwika. Ngati thandizo siliperekedwa munthawi yake, chitukuko, chikumbumtima chovulala chitha. Njira yothandiza kwambiri yochotsa metformin m'thupi ndi. Chotsatira, chithandizo chamankhwala chimayikidwa.

Kuchita

Zotumphukira za Metformin ndi sulfonylurea ziyenera kuphatikizidwa mosamala chifukwa choopsa cha hypoglycemia.

Mphamvu ya hypoglycemic imachepetsedwa mukamamwa glucocorticosteroids wambiri komanso wamba, glucagon, sympathomimetics, gestagens, adrenaline, chithokomiro cha chithokomiro, zotupa za nicotinic acid, thiazide diuretics, phenothiazines.

Ndi makonzedwe munthawi yomweyo, kuchotsedwa kwa metformin m'thupi kumachepa, chifukwa, chiwopsezo cha chiwonetsero cha lactic acidosis chikuwonjezeka.

Zotsatira za hypoglycemic zimatha kuphatikizidwa ndi β2-adrenoreceptor antagonists, angiotensin-converting factor inhibitors, clofibrate derivatives, monoamine oxidase inhibitors, non-steroidal anti-kutupa mankhwala, zotumphukira za cyclophosphamide.

Mukamagwiritsa ntchito intraarterial kapena intravenous kusiyanitsa mankhwala okhala ndi ayodini, omwe amagwiritsidwa ntchito pophunzira ma X-ray, pamodzi ndi Metformin, wodwalayo amatha kukula, ndipo mwayi wa lactic acidosis ukuwonjezeka.Ndikofunikira kuyimitsa phwando lisanachitike, panthawiyo komanso kwa masiku awiri pambuyo pake. Kuphatikiza apo, mankhwalawa amatha kubwezeretsedwanso ngati mawonekedwe a impso amawunikanso ngati abwinobwino.

Mukamamwa antipsychotic chlorpropamazine Mlingo wambiri, seramu shuga imachulukanso ndipo insulin imatulutsidwa. Zotsatira zake, kuchuluka kwa insulin kungakhale kofunikira. Koma izi zisanachitike, ndikofunikira kuti magazi anu azikhala ndi magazi.

Kupewa hyperglycemiasayenera kuphatikizidwa ndi Danazol.

Pogwiritsidwa ntchito kwa nthawi yayitali ndi metformin Vancomycin, Amilorida, , , Quinidine, , , Procainamide, Nifedipine, Triamterena plasma ndende ya metformin imawonjezeka ndi 60%.

Mayamwidwe a Metformin amachepetsa Guar ndi Cholestyramine, chifukwa chake, mutamwa mankhwalawa, kugwiritsa ntchito metformin kumachepa.

Imawonjezera mphamvu ya ma anticoagulants amkati, omwe ali m'gulu lamaphunziro.

Malangizo apadera

Ngati monotherapy yokhala ndi Metformin ikuchitika, hypoglycemia siinawonedwe. Chifukwa chake, wodwalayo amatha kugwira ntchito ndi makina olondola kapena magalimoto oyendetsa. Komabe, kuphatikiza kumwa mankhwalawo ndi insulin kapena ndi mankhwala ena omwe amagwiritsidwa ntchito pochiza matenda a shuga, zitha kuchitika hypoglycemia, yomwe, imayambitsa kuphwanya kwamphamvu kwamaganizidwe ndi mgwirizano wama kayendedwe.

Osamapereka mankhwala kwa anthu atakwanitsa zaka 60, ngati ali ndi mphamvu yolimba. Pankhaniyi, lactic acidosis imayamba.

Odwala omwe amamwa mankhwalawa amafunika kudziwa kuchuluka kwa creatinine m'magazi musanalandire chithandizo, kenako, mukamalandira chithandizo, pafupipafupi. Ndi mulingo wabwinobwino, izi ziyenera kuchitika kamodzi pachaka, ndi kuchuluka koyamba kwa creatinine, maphunziro otere akuyenera kuchitika kawiri pachaka. Maphunziro omwewo amachitika ndi pafupipafupi ofanana ndi okalamba.

Ngati wodwalayo ndi wonenepa kwambiri, ndikofunikira kuti azikhala moyenera nthawi yamankhwala.

Pambuyo pakuchita opaleshoni, mutha kuyambiranso chithandizo pambuyo masiku awiri.

Ma Analogs a Metformin

Kufanana kwa code ya ATX Level 4:

Ma analogi a Metformin ndi mankhwala osokoneza bongo Metformin Hydrochloride, Metformin Richter, Metformin teva, Metfogamma, Metospanin, Glycometer, Glycon, Vero Metformin, Orabet, Glyminfor, Novoformin. Palinso mankhwala angapo omwe ali ndi vuto lofananako (ndi ena), koma ndi ena omwe amagwira ntchito.

Kukonzanso mphamvu kwa metformin

Chithandizo chogwira mankhwalawa ndi metformin hydrochloride, yomwe imapangitsa kuchepetsa kukalamba kwa munthu.

Metformin poyambilira anafuna kuchiritsa matenda ashuga amtundu wa 2. Zinapezeka ndi asayansi aku Russia zaka 60 zapitazo. Kuyambira pamenepo, zambiri zalandiridwa pokhudzana ndi njira zake zothandizira pochiritsa. Anthu omwe ali ndi matenda ashuga omwe amamwa mankhwala a metformin amakhala 25% motalikirapo kuposa omwe alibe matendawa. Izi zimapangitsa asayansi kuphunzira mankhwalawa ngati njira yotalikitsira moyo.

Masiku ano, maphunziro angapo a metformin ngati mankhwala ochiritsira okalamba akuchitika padziko lonse lapansi. Makamaka, mu 2005 ku Oncology Research Institute yotchedwa N.N. Petrova, kafukufuku adachitika mu labotale kuti aphunzire za ukalamba ndi carcinogenesis, zomwe zimawonetsa kuti metformin imatalikitsa moyo. Zowona, kuyesaku kunachitika kokha pa nyama. Kuphatikizanso kwina, chifukwa cha kafukufukuyu, kudapeza kuti chinthucho chimatetezanso nyama ku khansa.

Pambuyo pa kafukufukuyu, gulu lonse la asayansi padziko lonse lapansi lidachita chidwi ndi zochita za metformin. Kuchokera nthawi imeneyo, kafukufuku wambiri wachitika omwe amatsimikizira zotsatira za kuyesa kwa 2005.

Zofunika! Mothandizidwa ndi anthu omwe amamwa mankhwalawo. Zinapezeka kuti mukamamwa mankhwalawo, chiopsezo chokhala ndi oncology chimachepetsedwa ndi 25-40%.

Mu malangizo ogwiritsira ntchito, simukuwona mawu omwe akuwonetsa mphamvu ya mankhwalawa pakukulitsa moyo. Koma, izi zimachitika kokha chifukwa chakuti ukalamba mwalamulo sunazindikiridwe ngati matenda.

Kodi metformin imakhudza bwanji thupi?

Kutulutsidwa kwamitsempha yamagazi kuchokera ku cholesterol plaques. Izi zimabweretsa kuti ntchito yofananira ya kuzungulira kwa dongosolo, imalepheretsa thrombosis ndi vasoconstriction. Mphamvu iyi ya mankhwalawa imathandizira kukulitsa unyamata wamtima mu mtima. Amadziwika kuti kuchuluka kwakukulu kwaimfa kumachitika chifukwa cha matenda amdongosolo lino.

Zimatsimikiziridwa kuti metformin imaletsa kukula kwa matenda a senile.

Kuwongolera kagayidwe kake ndikuwonjezera kuchuluka kwa cholesterol yopindulitsa ndikuchepetsa kuvulaza. Momwemo, pali kagayidwe koyenera m'thupi. Mafuta amamwetsedwa molondola, pamakhala pang'onopang'ono, osautsa, wotaya mafuta owonjezera ndi kulemera. Zotsatira zake, katundu pamakina onse ofunikira amachepetsedwa. Ngati, nthawi yomweyo akamamwa mankhwalawo, munthu amayamba kusintha moyo wake, zotsatira za mankhwalawo zimawonjezeka.

Anachepetsa chilako. Chinsinsi cha moyo wautali ndi kuwonda. Izi ndiye zowona. Metformin imathandizira kukwaniritsa ntchito iyi mwa kupondereza chilakolako chofuna kudya.

Kuchotsa shuga m'magazi am'mimba. Kutha kwa shuga kuthamangitsa njira zogwirizanirana zama mamolekyulu a protein kumathandizira kukalamba msanga komanso kumatenda ambiri.

Kuwongolera magazi. Kuchita izi kumachepetsa chiwopsezo cha kuundana kwa magazi, sitiroko komanso mtima. Matendawa akutsogolera mndandanda wazomwe zimayambitsa kufa msanga.

The zikuchokera mankhwala

• lilac
• muzu wa mbuzi
• talcum ufa
• magnesium wakuba,
• kukhuthala
• titanium dioxide
• crospovidone
• povidone K90,
• macrogol 6000.

Chofunikira chachikulu pakuphatikizidwa kwa mankhwalawo ndi metformin hydrochloride, yopangidwa kuchokera ku zinthu zachilengedwe zofunikira: lilac ndi muzu wa mbuzi. Komanso, mankhwalawa ali ndi zovuta zina zowonjezera, makamaka talc, magnesium stearate, titanium dioxide ndi omwe adalembedwa pamwambapa.

Malangizo a kumwa mankhwala

Kuti mugwiritse ntchito metformin kuti muchepetse kukalamba, muyenera kumwa mankhwalawa pa theka la mankhwalawo omwe akuwonetsa mu malangizo omwe angagwiritsidwe ntchito. Mankhwala othandizira amapatsidwa mankhwalawa. Koma, munthu wathanzi akamagwiritsa ntchito mankhwala amenewa, amatha kuvulaza kuposa zabwino.

Zofunika! Musanaganize zogwiritsira ntchito metformin, kuunika kwathunthu ndikofunikira. Izi ndizofunikira kuti muchepetse chiopsezo cha zotsatira zoyipa ndikuzindikira mtundu wa prophylactic.

Kugwiritsa ntchito mankhwalawa ngati anti-okalamba, ziwonetsero izi ziyenera kukumbukiridwa:

1. zaka siziyenera kupitirira zaka 30, koma osapitirira 60,
2. kunenepa kwambiri komanso kunenepa kwambiri,
3. mafuta a cholesterol ndi / kapena shuga ndi apamwamba kuposa abwinobwino.

Mlingo woyenera uyenera kuthandizidwa ndi dokotala ndikufotokozera momwe mungagwiritsire metformin. Kuti mumve, tikulimbikitsidwa kuti musatenge oposa 250 mg a metformin patsiku.

Kutenthetsa kwa Metformin

Ngakhale kuti bungwe la Metformin Richter ndi zothandizira zina zimalandira ndemanga zokhudzana ndi Metformin chifukwa cha kuwonda, chida ichi sichinapangidwe kuti chigwiritsidwe ntchito ndi anthu omwe akufuna kuti achotse. Mankhwalawa amachepetsa thupi amagwiritsidwa ntchito chifukwa cha zotsatira zake zomwe zimakhudzana ndi kuchepa kwa shuga wamagazi ndi kuchepa kwapakati pa thupi. Komabe, mutha kuphunzira zamomwe mungatenge Metformin kuti muchepetse kulemera kokha kuchokera kumagwero osadalirika pamaneti, chifukwa akatswiri samalangiza kuti azichita izi. Komabe, kuchepetsa thupi ndi mankhwalawa nthawi zina kumakhala kotheka kwa iwo omwe amatenga Metformin kuchiza matenda a shuga.

Ndi metformin iti yomwe ndiyabwino kupangidwanso?

Metformin imapangidwa pansi pa malonda osiyanasiyana ndipo amapangidwa ndi makampani ambiri:

• Metformin
• Glycon
• Metospanin
• Siofor
• Glucophagus,
• Glformin ndi ena.

Malo otetezeka komanso ovomerezeka kwambiri ku America, Russia ndi mayiko ena 17 aku Europe ndi Glucofage. Amaloledwa kutenga ngakhale ana azaka 10. Zimatsimikiziridwa kuti ndi Glucophage yomwe imayambitsa mavuto pang'ono, ndipo poletsa kukalamba imakhala pafupifupi 100% yotetezeka.

Komabe, ndikofunikira kufunsa dokotala za mankhwala omwe mungamwe metformin.

Ndemanga za Metformin

Ndemanga za Metformin pamapiritsi kuchokera kwa odwala omwe ali ndi matenda osokoneza bongo akuwonetsa kuti mankhwalawa ndi othandiza komanso amakulolani kuwongolera shuga. Maguluwa amafotokozanso za kusinthaku kwakuyenda bwino pochiritsidwa ndi mankhwalawa a PCOS. Koma nthawi zambiri pamakhala kuwunikiridwa ndi malingaliro a momwe mankhwalawo amachitikira Metformin Richter , Metformin teva ndipo ena amakulolani kuti muzilamulira thupi.

Ogwiritsa ntchito ambiri amati mankhwala okhala metforminadathandiziradi kuthana ndi mapaundi owonjezera. Koma nthawi imodzimodzi, zovuta zoyendetsedwa ndi m'mimba thirakiti zimawonetsedwa nthawi zambiri. Mukukambirana momwe metformin imagwiritsidwa ntchito pakuchepetsa thupi, malingaliro a madokotala amakhala osalimbikitsa. Amalangiza kwambiri kuti asazigwiritse ntchito pazifukwa izi, komanso kumwa mowa panthawi yamankhwala.

Mtengo wa Metformin, komwe mungagule

Mtengo Metformin muma pharmacies kutengera mankhwala ndi ma CD ake.

Mtengo Metformin teva 850 mg pafupifupi ma ruble 100 pa paketi 30 yama PC.

Kugula Metformin Canon 1000 mg (60 ma PC.) Ikhoza kukhala ya ma ruble 270.

Kuchuluka kwa Metformin, kutengera kuchuluka kwa mapiritsi omwe ali phukusi: 50 ma PC. Mutha kugula pamtengo wa ma ruble 210. Iyenera kukumbukiridwa mukamagula mankhwala ochepetsa thupi omwe amagulitsidwa ndi mankhwala.

• Mankhwala Ogulitsa Pa intaneti ku Russia
• Mankhwala apulogalamu apakompyuta Ukraine Ukraine

Metformin Richter mapiritsi 500 mg 60 ma PC.

Mapiritsi a Metformin Richter 850 mg 60 ma PC. Gedeon Richter Gideon Richter

Mapiritsi a Metformin-Canon 850 mg 60 ma PC. Canonfarm Production CJSC

Mapiritsi a Metformin-Canon 850 mg 30 ma PC. Canonfarm Production CJSC

Mapiritsi a Metformin-Canon 500 mg 60 ma PC. Canonfarm Production CJSC

Metformin ndi mankhwala omwe amadziwika ndi matenda a shuga a 2.

Metformin ndi m'gulu la mankhwala omwe amatchedwa biguanides.

Metformin imathandiza odwala omwe ali ndi matenda a shuga a 2 kuwongolera kuchuluka kwa glucose, amachepetsa mayamwidwe azakudya ndi kaphatikizidwe m'chiwindi. Mankhwalawa amathandizanso chidwi chachilengedwe cha maselo kuti apange insulin.

Kafukufuku wambiri akuwonetsa kuti mapindu a metformin sakhala ndi izi. Mu 2010, Medical News Today idafotokoza kafukufuku awiri yemwe adawonetsa kuthekera kwa Metformin kuteteza omwe amasuta ku khansa ya m'mapapo. Ndipo mu 2012, zidapezeka kuti metformin ikhoza kukhala yothandiza pochiza khansa ya kapamba.

Tsopano gulu lofufuza la University of Katolika ya Leuven (Katholieke Universiteit Leuven) ku Belgium lawonetsa kuti metformin ikhoza kuyimitsa ukalamba ndikupatsa moyo wautali.

Kuyesera kwa Roundworm

"Akamakula, nyongolotsi zazing'ono zimayamba kuchepa, ndikuyamba kuyenda pang'ono. Koma nyongolotsi zomwe tidapereka metformin zikuwonetsa kuchepa kochepa kwambiri ndipo sikununkha. Sikuti amakula pang'onopang'ono, amakhalanso athanzi kwa nthawi yayitali, "akutero a Haes, wolemba kafukufukuyu.

Koma kodi metformin imagwira ntchito bwanji? Gululi limafotokoza kuti maselo a thupi lathu amalandila mphamvu kuchokera ku mitochondria - microscopic "magetsi" omwe amapanga magetsi ochepa mkati mwa selo lililonse. Njirayi imayendetsedwa ndikupanga mitundu yambiri ya okosijeni (ma radicals).

Ma mamolekyulu oterewa amatha kukhala owopsa kwa thupi.Amatha kuwononga mapuloteni ndi ma DNA, kusokoneza magwiridwe antchito a maselo. Koma asayansi amati mutayang'ana pang'ono, mamolekyuwo amatha kukhala othandiza.

"Malingana ngati kuchuluka kwa molekyu yoopsa yomwe ilimo mu maselo ikhale yocheperako, izi zimathandizira pakukula kwa maselo. Maselo amagwiritsa ntchito ma molekyulu othandizira kuti asapweteke ena. Metformin imayambitsa kuwonjezeka pang'ono kwa chiwerengero cha mamolekyulu amenewo. Tikhulupirira kuti izi zimapangitsa kuti maselowo akhale olimba komanso kuti azikhala ndi nthawi yambiri yochezera, ”akufotokoza Haes.

Ma Antioxidants Angayanjane ndi Metformin

Komabe, ofufuzawo anachenjeza kuti ma antioxidants amatha kusintha momwe anti-kukalamba amakhudzidwira, chifukwa, m'malingaliro awo, mamolekyulu "oyipirawo" pamlingo wina wake ayenera kupezeka m'maselo athu.

Ngakhale zotsatira zoyesedwa ngati zowoneka mozungulira zikuwoneka bwino, Haes amalimbikitsa kufufuza kwina kuti: "Tiyenera kusamala ndi momwe zotsatirazi zimasinthidwira kwa anthu. Koma kafukufuku wathu ayenera kukhala maziko abwino pantchito ina mtsogolo. "

Mwa njira, sizokhazo zowerengeka zomwe zawonetsa kuthekera kwamphamvu kwa metformin. Chaka chatha, ogwira ntchito ku National Institute of Aging (NIA) adapeza kuti metformin idakulitsa chiyembekezo cha moyo wa mbewa zogwirira ntchito ndi 5.83% poyerekeza ndi gulu loyang'anira.

Zaka zaposachedwa, asayansi afika pakukhulupirira kuti ukalamba ndi matenda chabe omwe amatha kuchiritsidwa. Mankhwala aliwonse a pharmacological amapita kafukufuku osati pazomwe amafuna, komanso pa anti-kukalamba. Pali mankhwala ambiri padziko lapansi omwe amatha kutalikitsa moyo wa munthu, ndipo imodzi mwa izo ndi Metformin, yopangidwa ndi asayansi aku Russia zaka zoposa 60 zapitazo. Ndiye kodi imatenga nthawi yayitali bwanji?

Kodi Malysheva akuti chiyani za mankhwalawa?

Malysheva amalankhula za metformin mwatsatanetsatane mu pulogalamu yake ya "Health", pomwe amakafotokozera nkhaniyi pogwiritsa ntchito mankhwalawa pobwezeretsa. Gulu la akatswiri limatenganso mbali mu pulogalamuyi, yomwe imapereka mayankho ku mafunso ambiri okhudzana ndi machitidwe ndi mawonekedwe a mankhwalawo.

Mwamtheradi aliyense amalota kukhala ndi moyo komanso kukhala wachichepere kwa nthawi yayitali. M'mbuyomu, machiritso okalamba amatha kupezeka m'mabuku. Masiku ano, mankhwala ngati amenewo ndi enieni. Kodi zimathandizanso kutalikitsa moyo? Mutha kupeza yankho la funsoli m'nkhani yathu.

Kapangidwe ka mankhwala. Zambiri zamankhwala

Ndi anthu ochepa omwe amadziwa, koma chaka chino zidadziwika kuti asayansi adapanga njira yothandizira kukalamba. Kukula kwa mankhwalawa ndi kwa akatswiri a Yunivesite ya Altai. Asayansi akuti mankhwalawa amathandizira kubwezeretsa maselo omwe ali ndi vuto lothandizira thupi lonse. Mukamagwiritsa ntchito mankhwala atsopano, kukalamba kumachepa kwambiri.

Asayansi a Altai adapanga mankhwala ochiritsira okalamba sizabwino. Masiku ano, munthu aliyense wachiwiri padzikoli akuyesetsa kukhalabe ndi thanzi ndi unyamata m'njira iliyonse. Atolankhani ku Russian Federation adawona kuti mu February chaka chino, mankhwala omwe amachepetsa kukalamba adadutsa kale gawo lachiwiri la kuyesedwa. Mwinanso posachedwa titha kuwona machiritso okalamba pamashelefu amitundu yonse. Ndikofunika kudziwa kuti mankhwalawo ali ndi kuphatikiza kwakukulu. Malinga ndi asayansi a Altai, mankhwalawa samakhudzanso mphamvu ya munthu komanso chitetezo cha m'thupi. Pazifukwa izi, mankhwalawa alibe vuto lililonse. Ndizofunikanso kudziwa kuti kuchiritsa kwa ukalamba kumapangitsa kuti maselo atsopano akhale m'thupi la munthu.

Elena Malysheva ndi mankhwala ochepetsa ukalamba

Kanema wawayilesi "Live wathanzi!", Wopangidwa ndi Elena Malysheva, ndiotchuka kwambiri pakati pa omwe amayang'anira thanzi lawo mosamala. Chaka chino, pulogalamu yapa kanema wawayilesiyi idaphunzira mankhwala okalamba kuyambira ukalamba. Mutha kudziwa zambiri za iwo m'nkhaniyi.

Mankhwala okalamba kuchokera ku Malysheva amakulolani kubwezeretsa maselo amthupi. Mankhwala oyamba ndi zoletsa. Mankhwala oterowo sangathandize kuti mukhale achichepere kutalika, komanso kukonza mtima wamitsempha yamagazi. Mankhwalawa ndi monga Captopril, Ramipril ndi ena. Ndizofunikanso kudziwa kuti amachepetsa chiopsezo cholephera mtima.

Mankhwala atakalamba kuchokera ku Malysheva, malinga ndi wowonera TV, amatha kuthana ndi matenda ambiri. Mankhwala oterowo ndi Aspirin. Chifukwa cha mankhwalawa, chiopsezo cha kuwonongeka magazi, mikwingwirima ndi matenda a mtima amachepa. Monga lamulo, aspirin amaperekedwa kwa anthu azaka zopitilira 40.

Mankhwala omwe Elena Malysheva adalimbikitsa mu pulogalamu yake yapa kanema amathandizanso kukhala ndi thupi labwino komanso amachepetsa chiopsezo cha matenda oopsa. Musanagwiritse ntchito mankhwala aliwonse, timalimbikitsa kufunsa dokotala.

Kodi zotsatira za mankhwala a Altai zidayesedwa bwanji?

Monga tanena kale, asayansi a Altai apanga njira ina yothana ndi ukalamba. Pakadali pano, wadutsa magawo awiri oyesedwa. Mu Novembala chaka chino, akatswiri akukonzekera kuyamba kuyesa odzipereka.

Pachiyeso choyambirira, machiritso okalamba adayesedwa pazinyama, zomwe ndi mbewa. Adagawika m'magulu awiri. Woyamba adapatsidwa mankhwalawo, ndipo wachiwiri amakhala ndi moyo wabwinobwino. Patatha chaka ndi theka, zidapezeka kuti gululi, mogwirizana ndi momwe mankhwalawo sanagwiritsidwire ntchito, adayamba kuwonetsa zizindikiro za kukalamba, ndiko kuti, khalani, khungu, ndikuchepa thupi. Gulu lachiwiri la mbewa zomwe zimagwiritsa ntchito mankhwala othandizira Altai okalamba linali lambiri komanso lathanzi. Ndizofunikanso kudziwa kuti pambuyo pakupanga bwino, opanga mankhwalawa adayamba kudzipeza okha.

Kodi mankhwalawa adzagulitsidwa liti?

Nkhani yolenga njira yothetsera kukalamba yafalikira padziko lonse lapansi. Ambiri amavomereza kudzipereka ndikuyesera chaka chino. Mwina aliyense amene wamva nkhani yokhudza kupanga mankhwala ochepetsa ukalamba amakhala ndi chidwi ndi nthawi yomwe adzagulitse.

Monga tanena kale, mu Novembala chaka chino gawo lachitatu loyesera mankhwala liyamba, lomwe limachepetsa ukalamba. Pakhala maphunziro pa anthu omwe asankha kudzipereka. Asayansi a Altai samapereka tsiku lenileni la kulandira mankhwalawo pagulu la anthu. Komabe, akutsimikizira kuti izi zidzachitika zaka ziwiri.

"Metformin" - machiritso okalamba

Masiku ano, aliyense amafuna kukhala ndi moyo wautali komanso kuti azioneka ocheperako nthawi yomweyo. Asayansi ochokera kuzungulira padziko lonse lapansi akuyesera kupanga njira yochizira matenda okalamba. Metformin, yomwe amadziwika kuti ndi mankhwala a shuga, amawathandiza kuchita izi. Asayansi ochokera ku United States of America aganiza kuti ukalamba ndi matenda omwe ayenera kuthandizidwa. Chaka chatha, adapeza kuti Metformin imachepetsa kuwonongeka kwa thupi. Pamaziko ake, asayansi akukonzekera kupanga njira yothandizira kukalamba.

Metformin idayesedwa pa nyongolotsi. Ngakhale anali ndi zaka zambiri, khungu lawo silinkakhala losalala ndipo moyo wawo umakula kwambiri.

Mankhwala a altai cirrhosis

Mankhwala othandizira kukalamba, omwe adapangidwa ndi asayansi a Altai, ali ndi mikhalidwe ina yabwino. Monga tanena kale, pa gawo loyamba loyesedwa adayesedwa pa makoswe. Asayansi a Altai atsimikizira kuti mankhwalawa amathandizira kuti asachedwetse kukalamba, komanso amachiritsa matenda a chiwindi.M'makola omwe adapatsidwa mankhwalawo, maselo a chinthu chofunikira adabwezeretseka kwathunthu. Kutha kuchiritsa chiwindi ndikofunikira kwambiri pakapezeke chiphaso ku Unduna wa Zaumoyo.

Mankhwala omwe amachepetsa ukalamba ali kale mu mankhwala: nthano kapena zenizeni?

Ndi anthu ochepa omwe amadziwa, koma mankhwalawa okalamba ali kale m'mafakisi. Asayansi atsimikizira kuti mankhwalawa omwe amapangidwa kuti athandizire mafupa amachepetsa kwambiri njira zowonongeka. M'milandu yowonetsera mankhwala, mutha kuipeza mosavuta pansi pa dzina la Zoledronate. Akatswiri amakhulupirira kuti zimawonjezera nthawi yozungulira ya maselo a tebulo. Chifukwa cha izi, ntchito yogwira ntchito imakulanso, yomwe, monga mukudziwa, imachepetsa kwambiri ndi zaka. Masiku ano, asayansi akukonzekera maphunziro angapo ndikuwonetsa kuti mankhwalawa amathandizira kuti munthu akhale ndi moyo wautali.

Ngakhale kuti mankhwalawa amakalamba kale m'mafakitale, tikulimbikitsa kuti tisagwiritse ntchito zina. Itha kuvulaza thupi lanu.

Kufotokozera za mankhwalawa

Ambiri amati za Metformin kuti imachulukitsa moyo. Ndipo izi zikunenedwa ndi asayansi omwe akuchita maphunziro osiyanasiyana azachipatala a mankhwalawa. Ngakhale kutsimikizika kwa mankhwalawa kumawonetsa kuti imangotengera shuga mellitus 2T, yomwe imatha kulemedwa ndi kunenepa kwambiri komanso kukana insulini.

Metformin 500 mg

Itha kugwiritsidwanso ntchito kwa odwala matenda a shuga 1T. Komano, Metformin imangowonjezera insulin. Kuchokera pa zomwe zikuwonongeka zikuwonekeratu kuti anthu omwe ali ndi vuto logaya mafuta osavomerezeka sayenera kugwiritsa ntchito mankhwalawa.

Chimachitika ndi chiani ngati mutatenga Metformin popanda matenda a shuga? Yankho limaperekedwa ndi asayansi omwe adaphunzira momwe mankhwalawa amathandizira, kuletsa kukalamba kwa thupi, komanso kuchuluka kwa ma cell.

Mankhwala Metformin:

• imathandizira kufalikira kwa matenda a Alzheimer's, momwe ma cell a mitsempha omwe amachititsa kukumbukira kukumbukira,
• imalimbitsa maselo a tsinde, imathandizira kuti maselo atsopano a ubongo (ubongo ndi msana),
• imathandizira kubwezeretsa maselo amitsempha yama ubongo pambuyo pa sitiroko,
• amalepheretsa chitukuko cha multiple sclerosis.

Kuphatikiza pakuwongolera zinthu muubongo, Metformin imathandizira ntchito ya ziwalo zina ndi machitidwe a thupi:

• Amathandizira kupondereza kuperewera kwa thupi komwe kumachitika chifukwa cha kuchuluka kwa matenda ashuga a C,
• linalake ndipo tikulephera kukula kwa matenda omwe amayamba chifukwa cha ukalamba wa mtima, mitsempha yamagazi,
• zimasokoneza ma calcification wamitsempha, omwe amawononga ntchito ya mtima,
• amachepetsa chiopsezo chotenga khansa (Prostate, mapapu, chiwindi, kapamba). Nthawi zina amagwiritsidwa ntchito mu chemotherapy yovuta,
• zimalepheretsa matenda ashuga komanso mitundu yofananira,
• Amachita zachiwerewere mwa akulu,
• amachitira mafupa am'matumbo ndi nyamakazi yokhudzana ndimatenda a shuga,
• imakongoletsa ntchito ya chithokomiro,
• imathandiza impso ndi nephropathy,
• kumalimbitsa chitetezo chathupi
• Amathandizira kuteteza kupuma pamatenda.

Ntchito zotsutsa ukalamba za mankhwalawa zapezeka posachedwa. Izi zisanachitike, Metformin anali kugwiritsidwa ntchito kokha pothana ndi matenda a shuga. Koma zambiri zomwe zimapezedwa poyang'anira odwala omwe akuchiritsidwa ndi othandizidwawa adawonetsa kuti amakhala nthawi yayitali kuposa anthu opanda matenda awa.

Izi ndi zomwe zidapangitsa asayansi kuganiza zakuthana ndi kukalamba kwa Metformin. Koma malangizowo pakugwiritsidwa ntchito sikuwonetsa izi, chifukwa kukalamba si matenda, koma njira yachilengedwe yomaliza moyo.

Ndondomeko yokonzanso izi:

• kuchotsedwa kwa cholesterol plaque mu zombo. Chiwopsezo cha thrombosis chimachotsedwa, kufalikira kwa magazi kumakhazikitsidwa, kuthamanga kwa magazi kumatheka.
• kukonza kagayidwe kachakudya njira. Kulakalaka kumachepetsedwa, komwe kumapangitsa kuti muchepetse, kuchepa thupi komanso kusintha kulemera,
• utachepa m'mimba shuga. Kulumikizana kwa mamolekyulu a protein amapewedwa.

Metformin ndi ya m'badwo wachitatu biguanides. Zomwe zimagwirira ntchito ndi metformin hydrochloride, yomwe imathandizidwa ndi mankhwala ena.

Chiwembu chogwiritsira ntchito mankhwala motsutsana ndi matenda ashuga ndiwofatsa. Muli zoletsa njira ya gluconeogeneis, pomwe mukulimbikitsa glycolysis. Izi zimabweretsa kuyamwa bwino kwa shuga, pomwe kumachepetsa mayamwidwe ake m'matumbo. Metformin, osakhala othandizira pakupanga insulini, sikuti imayambitsa kutsika kwamphamvu kwa shuga.

Kugwiritsa ntchito Metformin, malinga ndi malangizo omwe aphatikizidwa ndi mankhwalawa, akuwonetsedwa:

• chiwonetsero cha insulin kukana kapena metabolic syndrome,
• kulolerana kwa shuga
• kunenepa kwambiri kokhudzana ndi matenda a shuga
• matenda otupa ovary,
• shuga mellitus 2T ndi zovuta chithandizo,
• shuga 1T ndi jakisoni wa insulin.

Folk yothetsera kukalamba

Monga tanena kale, mankhwala a Altai okalamba atha kugulitsidwa osachepera zaka ziwiri. Ngati mukufuna kukhalabe ndi unyamata wanu lero, mutha kugwiritsa ntchito mankhwala achikhalidwe, zomwe mungapeze mu nkhani yathu.

Kuti mupange, muyenera kusakaniza uchi 300 uchi, 200 magalamu a mandimu omwe mwangoyamba kumene ndi magalamu 100 amafuta. Timalimbikitsa kugwiritsa ntchito osakaniza tsiku lililonse, supuni imodzi mkati. Sungani elixir chotere mufiriji. Chifukwa cha wowerengeka, mawonekedwe anu adzasintha, makwinya ambiri adzatha ndipo chitetezo chokwanira chidzauka. Izi zimathandizira aliyense. Ngati mukusokonezeka ndi chimodzi mwa zosakaniza zamankhwala, tikukulimbikitsani kuti musakane kugwiritsa ntchito mankhwalawa.

Diso lodana ndi ukalamba

Zaka ziwiri zapitazo, asayansi aku America adayesa madontho amaso aku Russia. Adapeza kuti Visomitin ndimachiritso okalamba. Ndiwo madonthawa omwe samangowonjezera minyewa yamaso, komanso kubwezeretsa maselo ake. Pachifukwachi, asayansi aku America akufuna kupanga chida chomwe chitha kupangitsanso thupi lonse.

Pakadali pano, akatswiri adachita kuyesa pa makoswe. Mtsogolomu, asayansi akukonzekera kulemba anthu odzipereka zana limodzi kuti akayeze kwambiri mankhwala osokoneza bongo. Akutsimikiza kuti posachedwa aliyense adzakhala ndi moyo wabwino kwambiri.

Ukalamba wotsika mtengo

Tsoka ilo, chithandizo cha ukalamba chikupangika. Komabe, asayansi apeza chida chotsika mtengo chomwe chingapangire anthu okalamba kusintha thanzi lawo ndi kutalikitsa moyo. Ndi anthu ochepa omwe amadziwa, koma mafuta a nsomba, omwe amadziwika kwa aliyense kuyambira ali mwana, ndi chinthu chabwino kwambiri chomwe chimachedwetsa kuwonongeka mthupi. Chodabwitsa ndichakuti, m'maiko momwe nyanja kapena nyanja iliko, magwero ndi mavitamini ndi mchere wotere amatengedwa moyo wonse.

Asayansi atsimikizira kuti mwa anthu otere, poyerekeza ndi Russian Federation, chiopsezo cha matenda amtima chambiri chimachepa. Kuphatikiza apo, samakhala ndi mwayi wokhudzana ndi sclerosis komanso vuto lama neva. Ndi anthu ochepa omwe amadziwa, koma ku United States, mafuta a nsomba amalembetsa ngati mankhwala. Izi sizinachitike mwangozi, chifukwa anthu kumeneko amagwiritsa ntchito tsiku lililonse la mibadwo iliyonse. Mafuta a nsomba ali ndi phindu lalikulu m'thupi lathu. Zimakuthandizani kuti muchepetse kutupa komwe kumalumikizana, komanso ndilothandiza kwambiri painkiller. Ndi mafuta am'madzi omwe ali ndi kuchuluka kwakukulu kwa ma asidi omwe ali ofunikira m'thupi - Omega-3.

Chodabwitsa, chida, chodziwika bwino kwa aliyense kuyambira ali mwana, chitha kuthandizanso kuthana ndi vuto loyipa.Izi sizomwe zimachitika mwangozi, chifukwa mafuta a nsomba ali ndi zomwe zimapangidwa "mahomoni achisangalalo" - serotonin. Madokotala amalimbikitsa mwamphamvu kuti anthu achikulire aziphatikiza mafuta a nsomba muzakudya zawo. Zingathandize osati kuthana ndi mavuto ambiri, komanso kupewa matenda ambiri oyamba.

Ndikofunika kudziwa kuti palibe chizolowezi chakhazikitsidwa tsiku lililonse chakumwa mankhwalawa. Amasankhidwa payekha. Mutha kudziwa mosavuta izi kuchokera kwa dokotala. Mafuta a nsomba ndimachiritso okalamba, omwe samangokhala pagulu la anthu, komanso otchipa. Timalimbikitsa kwambiri kuphatikiza muzakudya zanu.

Mankhwala olimbana ndi ukalamba wa Altai kuti muthane ndi vuto la kubereka

Asayansi a Altai adayesa mayeso ambiri. Adapeza kuti njira yothandizira kukalamba imathandiza kuthana ndi chiwonongeko chokha, komanso matenda a chiwindi. Kodi mankhwalawa ali ndi zowonjezera zina?

Chodabwitsa, asayansi a Altai adazindikira kuti mankhwala awo amtsogolo azithandizira pobala anthu osabereka. Monga tidanenera kale, ntchito yayikulu ya mankhwalawa ndikukonza maselo. Pochita zoyesa pa makoswe, akatswiri adadzala mazira aanthuza. Modabwitsa, 99% ya maselo omwe adayambitsawo sanangokhala ndi moyo, komanso adakula kukhala makoswe akuluakulu. Mtsogolomo, omwe amapanga mankhwalawa amakonzekereranso ngati njira yothandizira kubereka.

Chozizwitsa chodabwitsa cha mankhwala a Altai. Mtengo wamankhwala

Monga tanena kale, asayansi a Altai adayesa mankhwalawo osati pa mbewa zokha, komanso pa iwo eni. Mmodzi mwa akatswiri anali ndi matenda osachiritsika omwe amayambitsidwa ndi adhesions. Pambuyo kanthawi, atagwiritsa ntchito mankhwalawa pafupipafupi, adazichotsa. Pachifukwa ichi, omwe amapanga mankhwalawa amati ali ndi mikhalidwe yabwino kuposa momwe amaganizira. Mtsogolomo, asayansi akukonzekera kuyesera zingapo zomwe zingathandize kudziwa zotsatira, kuwonjezera pakukonzanso, kumanyamula mankhwala.

Mtengo wa mankhwala amtsogolo osadziwika. Opanga amalonjeza kuti azichita zonse zomwe zingatheke kuti ikhale yotsika momwe angathere. Komabe, akugogomezera kuti mtengo wake udzakhudzana mwachindunji ndi kuchuluka kwa ma batchi omwe atulutsidwa.

Mwachidule

Lero, mankhwala ochiritsira okalamba asayansi a Altai akupangika. Mwinanso, patatha zaka zingapo, titha kugula mankhwala osavuta ngati awa ku pharmacy. Monga tanena kale, ndizotheka kuti zithandiza kuthana ndi chiwonongeko, komanso matenda ena akuluakulu. Ndipo pamene mankhwalawa akukula, tikukulimbikitsani kuti mukhalebe ngati thupi lanu pogwiritsa ntchito njira zina. Musanagwiritse ntchito mankhwala aliwonse, onetsetsani kuonana ndi dokotala. Khalani athanzi!

Metformin ndi piritsi yochepetsera shuga yomwe imagwiritsidwa ntchito ndi mtundu 2 odwala matenda ashuga (2T). Mankhwalawa akhala akudziwika kwazaka zambiri.

Katundu wake wotsitsa shuga adapezeka mu 1929. Koma Metformin idagwiritsidwa ntchito kwambiri kokha mu 1970, pomwe ma greatuanide ena adachotsedwa mu malonda.

Mankhwalawa amakhalanso ndi zofunikira zina, kuphatikizapo kuchepetsa kuchepa. Koma kodi ndizotheka kumwa Metformin ngati palibe shuga? Nkhaniyi iphunziridwa mwachangu ndi onse madokotala ndi odwala.

Ambiri amati za Metformin kuti imachulukitsa moyo. Ndipo izi zikunenedwa ndi asayansi omwe akuchita maphunziro osiyanasiyana azachipatala a mankhwalawa. Ngakhale kutsimikizira kwa mankhwalawo kumawonetsa kuti imangotengedwa ndi matenda a shuga mellitus 2T, omwe amatha kulemedwa ndi kunenepa kwambiri komanso.

Metformin 500 mg

Itha kugwiritsidwanso ntchito kwa odwala matenda a shuga 1T. Komano, Metformin imangowonjezera insulin. Kuchokera pa contraindication ndizowonekeratu kuti anthu omwe ali nazo samalimbikitsidwa.

Chimachitika ndi chiani ngati mutatenga Metformin popanda matenda a shuga? Yankho limaperekedwa ndi asayansi omwe adaphunzira momwe mankhwalawa amathandizira, kuletsa kukalamba kwa thupi, komanso kuchuluka kwa ma cell.

Mankhwala Metformin:

• imathandizira kufalikira kwa matenda a Alzheimer's, momwe ma cell a mitsempha omwe amachititsa kukumbukira kukumbukira,
• imalimbitsa maselo a tsinde, imathandizira kuti maselo atsopano a ubongo (ubongo ndi msana),
• amathandizira kubwezeretsa maselo amitsempha mu ubongo pambuyo,
• amalepheretsa chitukuko cha multiple sclerosis.

Kuphatikiza pakuwongolera zinthu muubongo, Metformin imathandizira ntchito ya ziwalo zina ndi machitidwe a thupi:

• Amathandizira kupondereza kuperewera kwa thupi komwe kumachitika chifukwa cha kuchuluka kwa matenda ashuga a C,
• imalepheretsa kukula kwa matenda omwe amayamba chifukwa cha ukalamba,
• zimasokoneza ma calcification wamitsempha, omwe amawononga ntchito ya mtima,
• amachepetsa chiopsezo chotenga khansa (Prostate, mapapu, chiwindi, kapamba). Nthawi zina amagwiritsidwa ntchito mu chemotherapy yovuta,
• zimalepheretsa matenda ashuga komanso mitundu yofananira,
• Amachita zachiwerewere mwa akulu,
• amachitira mafupa am'matumbo ndi nyamakazi yokhudzana ndimatenda a shuga,
• imakhazikitsa ntchito
• zimathandiza
• kumalimbitsa chitetezo chathupi
• Amathandizira kuteteza kupuma pamatenda.

Ntchito zotsutsa ukalamba za mankhwalawa zapezeka posachedwa. Izi zisanachitike, Metformin anali kugwiritsidwa ntchito kokha pothana ndi matenda a shuga. Koma zambiri zomwe zimapezedwa poyang'anira odwala omwe akuchiritsidwa ndi othandizidwawa adawonetsa kuti amakhala nthawi yayitali kuposa anthu opanda matenda awa.

Izi ndi zomwe zidapangitsa asayansi kuganiza zakuthana ndi kukalamba kwa Metformin. Koma malangizowo pakugwiritsidwa ntchito sikuwonetsa izi, chifukwa kukalamba si matenda, koma njira yachilengedwe yomaliza moyo.

Ndondomeko yokonzanso izi:

• kuchotsedwa kwa cholesterol plaque mu zombo. Chiwopsezo cha thrombosis chimachotsedwa, kufalikira kwa magazi kumakhazikitsidwa, kuthamanga kwa magazi kumatheka.
• kukonza kagayidwe kachakudya njira. Kulakalaka kumachepetsedwa, komwe kumapangitsa kuti muchepetse, kuchepa thupi komanso kusintha kulemera,
• utachepa m'mimba shuga. Kulumikizana kwa mamolekyulu a protein amapewedwa.

Metformin ndi ya m'badwo wachitatu biguanides. Zomwe zimagwirira ntchito ndi metformin hydrochloride, yomwe imathandizidwa ndi mankhwala ena.

Chiwembu chogwiritsira ntchito mankhwala motsutsana ndi matenda ashuga ndiwofatsa. Muli zoletsa njira ya gluconeogeneis, pomwe mukulimbikitsa glycolysis. Izi zimabweretsa kuyamwa bwino kwa shuga, pomwe kumachepetsa mayamwidwe ake m'matumbo. Metformin, osakhala othandizira pakupanga insulini, sikuti imayambitsa kutsika kwamphamvu kwa shuga.

Kugwiritsa ntchito Metformin, malinga ndi malangizo omwe aphatikizidwa ndi mankhwalawa, akuwonetsedwa:

• chiwonetsero cha insulin kukana kapena metabolic syndrome,
• kulolerana kwa shuga
• kunenepa kwambiri kokhudzana ndi matenda a shuga
• matenda otupa ovary,
• shuga mellitus 2T ndi zovuta chithandizo,
• shuga 1T ndi jakisoni wa insulin.

Koma kodi Metformin ingatengedwe ngati palibe shuga? Inde, pali zinthu zina zamankhwala zomwe zimatha kuthana ndi kunenepa kwambiri komanso kukalamba mwa anthu opanda matenda a shuga.

Kuchepetsa Ntchito

Kodi ndizotheka kumwa Metformin kuti muchepetse thupi, ngati shuga ndichabwinobwino? Kuwongolera uku pakukhudzana ndi mankhwala chifukwa cha kuthekera kwake kumenya nkhondo osati ma plaque m'mitsempha yamagazi, komanso ma deposits amafuta.

Kuchepetsa thupi mukamamwa mankhwala kumachitika chifukwa chotsatira:

• kuthamanga kwamafuta oxidation,
• kuchepa kwa kuchuluka kwa zomwe mwapeza
• kuchuluka kwa glucose pogwiritsa ntchito minofu.

Izi zimachotsanso kumverera kwanjala yosalekeza, zimathandizira kuti thupi lizikula mofulumira.Koma muyenera kutentha mafuta mukudya.

Kuti muchepetse kunenepa, muyenera kusiya:

Masewera olimbitsa thupi, monga masewera olimbitsa thupi olimbitsa thupi tsiku lililonse, amafunikanso. Ma regimen akumwa ayenera kuyang'aniridwa mosamala. Koma kumwa mowa ndikoletsedwa.

Tiyenera kukumbukira kuti kuchepa thupi kumangowonjezera mphamvu ya mankhwalawo. Ndipo adokotala okha ndi omwe angadziwe kufunika kwa Metformin kuti athane ndi kunenepa kwambiri.

Ntchito yoletsa kukalamba (anti-okalamba)

Metformin imagwiritsidwanso ntchito polepheretsa kusintha kokhudzana ndi zaka m'thupi.

Ngakhale mankhwalawa siwopanda chiyembekezo chaubwana wamuyaya, amakulolani:

• bwezeretsani kuchuluka kwa bongo ku mawu ofunikira,
• kuchepetsa chiopsezo cha neoplasms yoyipa,
• limbitsani mtima minofu.

Vuto lalikulu la chiwalo chokalamba ndi atherosulinosis, yomwe imasokoneza kugwira ntchito kwa mtima ndi mitsempha yamagazi. Ndiye amene amayambitsa imfa zambiri zomwe zimachitika asanakwane.

Zotsatira za cholesterol yomwe imatsogolera ku atherosulinosis imachitika chifukwa:

• kuphwanya kachitidwe koyenera ka kapamba,
• kulakwitsa kwa chitetezo chamthupi,
• mavuto a metabolic.

Cholinga chake ndikukhalanso ndi moyo womwe anthu okalamba amatsogolera, pomwe amakhala ndi chakudya chambiri komanso zopatsa mphamvu, ndipo nthawi zina zimawonjezera.

Izi zimabweretsa kukokomeza magazi m'mitsempha ndikupanga ma cholesterol amana. Mankhwalawa amathandizira kuchepetsa mafuta m'thupi, kusintha kayendedwe ka magazi ndi kusintha ntchito ya ziwalo zonse ndi machitidwe. Ndiye kodi Metformin ingatengedwe ngati palibe shuga? Ndizotheka, koma pokhapokha ngati pali contraindication.

Zoyipa pa Metformin ndi:

• acidosis (pachimake kapena chovuta),
• nthawi ya pakati, kudyetsa,
• Matendawa ndimankhwala
• chiwindi kapena vuto la mtima,
• myocardial infaration
• Zizindikiro za hypoxia mukamwa mankhwalawa.
• kuchepa kwa thupi ndi matenda opatsirana,
• matenda am'mimba thirakiti (zilonda),
• kuchita zolimbitsa thupi kwambiri.

Lemberani Metformin kuti muchepetse thupi komanso kuti musinthe thupi ndikufunika kukumbukira zotsatirapo zoyipa:

• chiopsezo chowonjezereka cha anorexia
• mseru, kusanza, kutsegula m'mimba kumachitika,
• nthawi zina kukoma kwazitsulo kumawonekera
• kuchepa magazi kumatha kuchitika
• pakuchepa kwa mavitamini a B, ndipo kukonzekera kowonjezereka kumafunikira,
• kugwiritsa ntchito kwambiri, hypoglycemia ingachitike,
• Kuchita zosafunikira kungayambitse mavuto amtundu wa khungu.

Makanema okhudzana nawo

Makhalidwe a pharmacological ndi malangizo ogwiritsira ntchito mankhwala Metformin:

Njira yogwiritsira ntchito Metformin osati pochiza matenda ashuga siyachilendo. Kuyambitsa kudzipanga nokha ndikusankha mulingo woyenera panokha osakambirana ndi othandizira azaumoyo ndizowopsa zomwe sizingachitike. Ndipo ziribe kanthu kuti awongolere motani odwala, kumva kwa dokotala kuti achepetse kulemera / kukonzanso mothandizidwa ndi Metformin ndikofunikira.

Pharmacological zimatha mankhwala

Metformin ndi mankhwala ochokera ku kalasi ya biguanides, yomwe imagwiritsidwa ntchito mwachangu pochiza matenda amtundu wa 2 shuga.

Chofunikira chachikulu cha mankhwalawo ndi Metroformin hydrochloride, silicon dioxide, povidone, magnesium stearate, macrogol amagwiritsidwa ntchito ngati zida zothandiza.

Mankhwalawa amagwiritsidwa ntchito mwachangu kuchepetsa magazi. Nthawi yomweyo, kuchepa kwa zizindikiro kumachitika osati pambuyo pa chakudya chachikulu, komanso kumakupatsani mwayi kuti muchepetse maziko. Gawo lalikulu la mapiritsi limakupatsirani mwayi wopanga insulin ndi kapamba, yemwe amakhudza thupi ndipo samatulutsa chiwopsezo cha hypoglycemia. Kuphatikiza apo, zina mwazabwino ndi izi:

• kulowerera kwa hyperinsulinomy,
• zimapangitsa kuchepetsa thupi,
• amachepetsa chiopsezo cha matenda opatsirana ndi mtima,
• zimakhudza kagayidwe kazida ka lipid m'thupi,
• amachepetsa makutidwe ndi mafutawa,
• Amachepetsa kuchuluka kwa cholesterol yoyipa,
• amachepetsa chiopsezo cha matenda a shuga,
• amachepetsa triglycerides.

Mankhwalawa amatengedwa pakamwa, pambuyo pake patatha maola awiri kapena atatu ntchito yake yayikulu imayamba kuonekera. Pafupifupi maola asanu ndi limodzi atatha kumwa mankhwalawa, plasma ndende ya metformin imachepa, popeza kuyamwa kwa chinthucho kumatha.

Mukamalandira mankhwalawa pakapita masiku angapo, mutha kuwona kupezeka kwake kosalekeza m'magazi ochepa.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala Metformin amapezeka mu mawonekedwe apiritsi osiyanasiyana. Mankhwalawa atha kugulidwa ku malo azamankhwala azigawo mwanjira zotsatirazi:

• 500 mg yogwiritsa ntchito piritsi limodzi,
• 850 mg yogwira pophika
• 1000 mg ya metformin.

Kutengera mlingo wake, malamulo omwera mankhwalawa amadalira. Dziwani kuti ndi madokotala okhawo omwe angalimbikitse kugwiritsa ntchito mankhwalawa, kuphatikizapo m'malo mwa mankhwala omwe adamwa kale. Njira ya chithandizo imafotokozedwa Mlingo womwe umachokera ku chithunzithunzi chachikulu cha matenda ndi mthupi la wodwalayo. Chizindikiro chachikulu chomwe muyenera kulabadira posankha mlingo ndi kuchuluka kwa glucose m'magazi ndi gawo la kulemera kwa wodwala.

Mlingo wocheperapo womwe mankhwalawa amayamba ndi 500 mg ya mankhwalawa ndikuwonjezereka kwina. Komanso, muyezo umodzi womwewo sungathe kupitirira chiwerengero chomwe chatchulidwa pamwambapa. Kuti mulekerererane bwino mankhwalawo, komanso ngati pali Mlingo wokhazikika, kuchuluka kwake kungagawike pawiri kapena katatu masana. Chifukwa chake, zitha kuteteza kukula kwa zoyipa. Mulingo woyenera wa mankhwalawa sayenera kupitirira 3000 mg yogwira ntchito.

Nthawi zina, mwachitsanzo, kumwa mankhwalawa chifukwa cha prophylactic, mlingo umayenera kuchepetsedwa kawiri kapena katatu.

Kuchuluka kwa kumwa mankhwalawa kumatheka patatha milungu iwiri ya chithandizo.

Ngati, pazochitika zina, mankhwala adasowa, palibe chifukwa chowalipirira pochulukitsa mlingo wotsatira.

Mukamamwa mankhwalawa, ndikofunikira kuganizira njira yachilengedwe ya kagayidwe kachakudya ndi thanzi labwino.

Tiyenera kudziwa kuti pali chiopsezo chachikulu cha lactic acidosis.

Zotsatira zoyipa za kumwa mankhwalawa

Chithandizo ndi chithandizo ndi Metformin ziyenera kuchitika moyang'aniridwa ndi achipatala. Ndizosavomerezeka kumwa mankhwalawa mu Mlingo wopitilira malangizo a dokotala, kapena molumikizana ndi mankhwala ena osankhidwa ndi wodwalayo.

Kugwiritsa ntchito molakwika kwa Metformin kumatha kuyambitsa zovuta zambiri, zovuta zamavuto a thupi la munthu atseguka.

Zowonetsa zazikulu za mankhwalawa zimaphatikizapo izi:

• kugaya chakudya cham'mimba, komwe kumayendetsedwa ndi kuseketsa, kupweteka m'mimba kapena kutsekula m'mimba,
• utoto wopanda mchere mkamwa utha kuwonekera mutatha kudya,
• kusanza ndi kusanza
• Kuperewera kwamagulu angapo a mavitamini, makamaka B12, motero tikulimbikitsidwa kuti kudya kowonjezereka kwama mankhwala apadera omwe amatha kusintha magawo onse a zinthu zofunika mthupi,
• kuwonetsedwa kwa thupi lawo siligwirizana pa chimodzi kapena zingapo za mankhwalawo.
• mawonekedwe a hypoglycemia,
• kukula kwa lactic acidosis,
• megaloblastic.

Ndipo ngakhale Metformin ikuphatikizidwa ndi gulu la mankhwala otetezeka, muyenera kuwerenga mosamala mawunikidwe onse oyipa. Mankhwala oterowo amatha kukhala owopsa ngati simutsatira malamulo oyenera kutsata.

Chimodzi mwazinthu zoyipa zomwe zimachitika chifukwa cha mankhwalawa ndi lactic acidosis. Vutoli limayendera limodzi ndi zizindikiro monga kugona kwambiri, kuwonda minofu, kuchepa thupi komanso kuthamanga magazi, komanso kupuma movutikira. Ndi kukula kwa matenda oterewa, wodwala amafunikira kuchipatala mwachangu.

Lactic acidosis ndi imodzi mwazotsatira zoyipa zomwe zimachitika chifukwa cha mankhwala osokoneza bongo ambiri.

Kodi milandu ndi yoletsedwa liti?

Mankhwala Metformin ali ndi mndandanda wofunikira wa zotsutsana ndikugwiritsa ntchito kwake.

Chifukwa chake, musanayambe maphunziro, muyenera kuwerenga malangizo mosamala. Zotsatira zoyipa zilizonse zikachitika, muyenera kufunsa dokotala ndi kukambirana zina za mankhwalawa.

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pamaso pa zinthu ndi matenda:

• zochizira mtundu 1 shuga, odwala a insulin,
• kukula kwa ketoacidosis, chikomokere kapena kholo la mtundu wa matenda ashuga,
• zovuta za pathological mu impso kapena chiwindi, komanso pamaso pa kusakwanira,
• Matenda ena am'mapapo, komanso vuto la kupuma,
• Matenda a mtima, kulephera kwa mtima kapena kulowerera m'mitsempha,
• kukula kwa matenda oyambitsidwa ndi matenda osiyanasiyana,
• opaleshoni yaposachedwa komanso kuvulala,
• mawa komanso pambuyo pofufuzafufuza, zimaphatikizapo kufufuza radiology kapena radioisotropic, popeza wogwiritsa ntchito iodine amagwiritsidwa ntchito.
• lactic acidosis
• tsankho kapena hypersensitivity ku chimodzi kapena zingapo za mankhwalawa.
• pamaso pa madzi am'madzi,
• uchidakwa wosalekeza kapena uchidakwa wokhazikika.

Atsikana ndi amayi oyembekezera panthawi yoyembekezera amaletsedwa kutenga Metformin, chifukwa mavuto osiyanasiyana ndi kukhazikika kwa mwana wosabadwayo angachitike. Ndi chifuno chofunikira chamankhwala, mayi ayenera kusiya kuyamwitsa.

Kuphatikiza apo, ana osakwana zaka khumi ndi zisanu ali pachiwopsezo.

Mndandanda wa mankhwala Metformin

Metformin ndi muyezo wagolide wofunikira pazigawo zonse za kukulitsa kwa chithandizo cha matenda a shuga a 2. Ngakhale zinali zofanana ndi zosiyana pamalingaliro, patadutsa zaka makumi angapo, adasintha kwambiri njira zochizira matenda ashuga amtundu wa 2.

Msika wamakono wamankhwala uli ndi magulu khumi a mankhwala omwe amapangidwa kuti athe kuthana ndi matenda amtundu wa 2, koma Metformin, monga wophunziridwa kwambiri komanso wogwiritsidwa ntchito kwambiri pamagulu onse a matendawa, sanathere pomwepo.

Awa ndi mankhwala okhawo omwe amadziwika kuti amapambana mu monotherapy, kulimbitsa kwambiri sikuthandizanso popanda kutenga nawo mbali. Kodi nchifukwa ninji anayenera kutchuka chotere?

Metformin ndi mankhwala okwera mtengo komanso okhala ndi umboni wamphamvu: ngati mungafufuze pa database ya Pubmed pazaka khumi zapitazi, mutha kupeza zolemba zambirimbiri zomwe zimafufuza kwambiri za Metformin popewa komanso kuchiza matenda amtundu wa 2 matenda, matenda a antitumor ndi mtima.

M'malo mwake, Metformin imachulukitsa moyo wa anthu athanzi, ndikupangitsa kufotokozera kwa majini okhala ndi moyo wautali.

Kafukufuku wachipatala apeza kuti kugwiritsa ntchito Metformin pafupipafupi kumachepetsa ndi kufa kwachitatu, kufa chifukwa cha kulowetsedwa ndi matenda osokoneza bongo, kumathandizira kupulumuka kwa odwala khansa, ndikuchepetsa mwayi wokhala ndi khansa ya m'mawere m'matenda a matenda ashuga.Kuphatikiza apo, mankhwalawa amatulutsa mphamvu yoletsa kudya kwa caloric, njira yodalirika kwambiri yotalikitsa moyo.

Kodi chimapangitsa kuti chithandizire ndi chiyani?

1. Mankhwala amasintha insulin,
2. Amathandizira kuwongolera glycemic,
3. Fibrinolysis imakhala bwino
4. Microcirculation mu zotumphukira zimakhala zimayambitsa,
5. Endothelial kukanika kumachepa
6. Potengera maziko a metformin, hyperglycemia imachepa,
7. Mapangidwe a kumapeto kwa glycation kumapeto kumachepetsedwa,
8. Kuchulukana kwa magazi kumaundana
9. Kupanikizika kwa Oxidative sikutenga mbali,
10. Zothandiza pa atherogenesis ndi dyslipidemia.

Mankhwalawa amachepetsa chiopsezo cha zochitika za mtima ndi matenda ashuga omwe ali ndi mtundu wachiwiri wa matenda, ndipo zotsatira za kukumbukira kwa metabolic zimakuthandizani kuti musunge zotsatira kwanthawi yayitali.

Chithandizo ndi Metformin ndi zotumphukira zake zimachepetsa kwambiri glycemia.

Poyerekeza ndi ma analogi ndi mankhwala ena osokoneza bongo, Metformin imathandizira kulemera ndipo imathandizira kuchepetsa.

Kafukufuku wazaka zisanu zaku China wazaka zisanu, zomwe zidakhudza odwala matenda ashuga 6,800 omwe ali ndi vuto lachiwiri popanda mbiri ya matenda amtima, adawonetsa kuti m'gululi pomwe omwe akuchita nawo kafukufukuyu adatenga metformin kuwonjezera pa kusintha kwa moyo, kuchuluka kwaimfa kunali milandu 7.5 pa Anthu 1000 / zaka (kwa miyezi 62,5).

Tili pagulu lolamulira, pomwe odzipereka odwala matenda ashuga anali ochepa pamasinthidwe amachitidwe, kuchuluka kwaimfa kunali milandu 11.1 pa munthu aliyense wazaka 1000 (kwa miyezi 44.5).

Pulofesa E. Malysheva amalankhula za kuthekera kwa Metformin mu kanema:

Kukonzekera komweku ndi mayina amalonda

Bizinesi yamankhwala ndi amodzi omwe amapindulitsa kwambiri, ndipo kampani yokha yaulesi siyipanga mankhwala okhala ndi metformin yogwira. Masiku ano, palinso mankhwala ofanana ndi mitundu ingapo - kuchokera pamtundu wamtundu kupita nawo kwambiri.

Mankhwala oyamba ali ndi dzina lapadziko lonse - metformin hydrochloride. Mankhwala kuchokera pagulu la ma biagunides, m'gulu lino la mankhwala akadali amodzi. Zina zonse zomwe timapeza mu pharmacy network ndi mayina amalonda amakampani omwe amatulutsa metformin yomweyo.

Pamene wothandizira kapena endocrinologist akapatsa wodwala matenda ashuga, Metformin adzawonetsedwa pamenepo.

Mtundu wa mankhwalawo udzakhala wotani ndikutengera kwa malo ogulitsira komanso mabungwe olamulira amasayina zikalata zovomerezeka zogulitsa mtundu wina wa mankhwala.

Mwachitsanzo, mabungwe olamulira alowa mu mgwirizano ndi Akrikhin. Chifukwa chake, mumasamba omwe mumapatsidwa Glyformin (a genformin a Metformin), osati Glucofage (oyambayo). Chifukwa chake kumuimba mlandu dokotala kuti apereke mapiritsi oti "sanalakwe" kulibe ntchito - uku si luso lake. Fomuyi ikuwonetsa dzina losakhala laudindo.

Mankhwala atsopano asanalowe mu netiweki yogawa, zimatenga mpaka zaka 10. Nthawi yonseyi, Metformin idafufuzidwa ndi kampani imodzi yopanga mankhwala omwe amapanga zoyambira. Mtsogolomo, monga lamulo, amagulitsa patent yopanga mankhwala kwa aliyense. Mankhwala operekedwa ndi makampani awa amatchedwa ma generics.

Zoyambirira zimasiyana ndi zonse mu mtengo komanso mtengo, chifukwa Metformin idaphunziridwa molondola momwe amapangidwira, kuphatikiza kapangidwe kazigoba ndi ena ojambula. Majini amatulutsidwa ndi zowonjezera zina zomwe sizinadutse zaka zambiri za kafukufuku, zomwe zikutanthauza kuti kuthekera kwawo kudzatsikira.

Mankhwala oyambirirawo amatchedwa Glucophage, ndipo amapangidwa ku France. Metformin ili ndi mitundu yambiri, koma ogula ambiri amakonda:

Pali mankhwala ambiri mu netiweki yogawa ndi mizu yaku China kapena India, ndipo adzakhala otsika mtengo kwambiri kuposa omwe alembedwa, koma kugwira ntchito kwawo kumayeneranso ndi mtengo.Pa Metformin, mtengo womwe umapezeka m'mapiritsi a mankhwala amachokera ku 94 mpaka 287 ma ruble ndipo zimatengera mlingo, kampani, kuchuluka kwa mapiritsi.

Zosiyanasiyana Metformin zotheka monga Glucofage-akhala akupanga. Nthawi zambiri, mankhwala ophatikizika a metformin amagwiritsidwa ntchito mwanjira zopangira mankhwala osakanikirana - Gluconorm, Glucovans, Glibomet, Galvus Mete, Yanumet, Amarile M ndi ena. Iwo omwe amalandira mankhwalawo kwaulere alibe njira, koma ngati thanzi ndi lokwera mtengo kuposa ndalama ndipo pali chisankho, yang'anirani mlingo wake.

Njira zowonetsera mankhwala osokoneza bongo

Metformin ya antidiabetesic ili ndi katundu wotsitsa shuga, zomwe zikutanthauza kuti sizingalimbikitse kupanga kwa insulin ndi insulin ndikuchulukitsa ziphuphu, zomwe zimagwira kale ntchito moyenera.

Chachikulu zotumphukira mankhwala:

Ubwino wina wa Metformin ndikusowa kwa kukondoweza kwa ma cell omwe amayankha pakupanga insulin, chifukwa mu odwala matenda ashuga awonongedwa kale.

Metforminum: Zizindikiro zogwiritsidwa ntchito

Chinsinsi cha kukalamba ndi kuchuluka kwa glycemia. Mapuloteni amawerengedwa, makwinya amapezeka pakhungu, ming'alu imawoneka m'matumbo, momwe mafupawo amapanga liwiro lalikulu, mamolekyulu awiri amafuta amapanga molekyulu imodzi ya glucose yopanda phindu.

Koma zotumphukira za metformin sikuti ndim mankhwala ochepetsa shuga okha. Mankhwala ndiwofunikira kwambiri pakakhala vuto la kulolera kwa glucose komanso glycemia wofulumira.

Pali chidziwitso chatsopano chakugwiritsa ntchito metformin pochiza matenda amtundu wa 2 shuga komanso kunenepa kwambiri kwa ana okulirapo zaka 10.

Pamodzi ndi matenda a glycemia, njira zambiri zaukalamba zimachepetsa - kukulira kwa atherosulinosis, kuthamanga kwa magazi kumatulutsa, ndipo mapuloteni osadziwika amakhala olimba. Mlingo wa metformin kuti ukhale ndi moyo nthawi yayitali mpaka 250 mg / tsiku.
Metformin lero sikuti ndi mtundu wokhawo wa shuga: sagwiritsidwa ntchito ndi ma endocrinologists okha, komanso akatswiri azachipatala, akatswiri a zamankhwala, oncologists, ndi ma gynecologists.

Canadian Diabetes Association imalimbikitsa kugwiritsa ntchito Metformin kuchiza odwala omwe ali ndi vuto la mtima.

Zotsatira zoyipa

Mankhwala onse opanga alibe zabwino zokha, komanso zovuta, ndipo metformin ndiyosiyana ndi izi. Zotsatira zoyipa kwambiri ndizokhumudwitsa m'mimba.

Oposa 20% ya odwala matenda ashuga omwe akutenga Metformin ali ndi zodandaula:

Poyerekeza ndi metformin poyerekeza ndi anthu odwala matenda ashuga, nthawi zambiri zinthu izi zimawonekera poyambira chithandizo ndikusowa patangopita sabata limodzi. Izi zitha kufotokozedwa popewa kulowetsa shuga m'makoma a m'matumbo ang'ono; chifukwa, kupsa ndi mpweya kumawonedwa. Zotsatira zake, izi zimachitika mutamwa mankhwalawa, ndipo m'mimba mumatupa. Pakatha milungu ingapo, matumbo azolowera ndipo amayankha modekha.

Ngati matenda am'mimba atatha kumwa mankhwalawa amadzetsa chisangalalo chachikulu, mankhwalawo amathetsedwa kwakanthawi kapena kuti mlingo umachepetsedwa. Ngati izi sizili zokwanira ndipo kuphwanya malamulo sikunadutse, mankhwalawo ayenera kusinthidwa. Pongoyambira - analogue ya wopanga wina.

Malinga ndi odwala matenda ashuga, metformin, mankhwala oyamba omwe ali ndi dzina la malonda Glucofage, ali ndi zovuta zochepa.

Thupi lawo siligwirizana (erythema, totupa, kuyabwa kwa khungu) ndizosowa, koma amafunikira mankhwala mwachangu. Zachidziwikire, muyenera kukumbukira nthawi zonse za lactic acidosis, chifukwa mu 50% ya milandu imeneyi imabweretsa imfa.

Metformin: malangizo ogwiritsira ntchito

Mankhwalawa amalembedwa pamlingo wa prediabetes, komanso monga kupewa patatha zaka 45. Awa ndiwo mankhwala okhawo omwe ali abwino kwa odwala matenda ashuga omwe ali ndi mtundu wachiwiri wamatenda oyambira monotherapy. Kuyambitsidwa panthawi yake ndi chitsimikizo cha kuchita bwino.

Mu Metformin, mawonekedwe omasulira ndi mitundu iwiri ya mapiritsi: mtundu wautali komanso wachilendo. Amasiyana pakukhudzana ndi nthawi komanso mlingo.

Mu mtundu wophatikizidwa, metformin ikhoza kukhala ndi Mlingo wosiyana: mwachitsanzo, ku Glibomet kulemera kwake ndi 400 mg.

Kumayambiriro kwa maphunzirowa, mlingo wocheperako umasankhidwa - 500 mg / tsiku. Muyenera kugwiritsa ntchito piritsi mosamalitsa ndi chakudya kapena pambuyo pake. Pambuyo pa masabata 1-2, mlingo umasinthidwa ngati kusintha kwa moyo ndi kumwa poyambira sizikuwonetsa zotsatira zomwe mukufuna. Kwa Metformin, mlingo waukulu wa tsiku ndi tsiku ndi 2000 mg / tsiku. Ngati mumamwa mapiritsi musanadye, mphamvu zake zimachepetsedwa kwambiri.

Ndikofunikira kumvetsetsa kuti popanda kuyang'ana mfundo zachakudya zamafuta ochepa komanso kuchita masewera olimbitsa thupi mokwanira, mphamvu ya Metformin imachepetsedwa kwambiri.

Metformin imaphatikizana bwino kwambiri ndi magulu onse a mankhwala antidiabetes, kuphatikiza insulini, ndipo amagwiritsidwa ntchito kuphatikiza mankhwala ndi DPP-4 inhibitors, sulfonylureas, thiazolidinediones, ndi b-glucoosidase inhibitors. Kuthekera kwa mankhwalawa sikuwoneka pompopompo: ndikofunikira kuyesa mphamvu ya glycemia pasanathe sabata ziwiri pambuyo pa kudya kwa Metformin koyamba.

Yang'anani shuga wanu mosavuta ndi glucometer yonyamula m'mawa (musanadye chakudya cham'mawa), maola awiri mutatha kudya komanso musanagone. Ndikofunika kuwongolera kuti zopangika pakati pa zokhwasula sizipitirira maola 4-5. Ngati zisonyezo za glycemic zomwe sizikuyendetsedwa sizikufikireni panthawi yomwe yaperekedwa, muyezo ungasinthidwe mu gawo lovomerezeka.

Kutalika kwa mankhwala

Matenda a shuga ndi njira yamoyo wonse, ndipo ndizosatheka kudziwa kuti maphunzirowa atenga nthawi yayitali bwanji. Zonse zimatengera umboni komanso cholinga chomwe mukufuna. Ngati cholingacho ndichakanthawi kochepa, mwachitsanzo, kuchepa thupi, ndiye kuti mankhwalawo amachotsedwa atangopeza zotsatira zomwe mukufuna.

Ndi matenda a shuga a mtundu 2, kuphwanya kwa chakudya chamafuta kumakhala kovuta kwambiri, motero, zimatenga nthawi yayitali kumwa mankhwalawo. Munthawi zonsezi, njira zochizira zimasinthidwa ndi adokotala.

Mu chithunzichi - zitsanzo zamankhwala pakuwerengera kuchuluka kwa chithandizo cha mankhwalawa ndi metformin (Chinsinsi cha Latin - Rp Tab. Metformini).

Kuthandiza ndi bongo

Mlingo wa hypoglycemia mwangozi kapena mwangozi suwopsezedwa, ndipo lactic acidosis ndiyotheka. Vuto loopsa limatha kupha ngakhale mutalandira chithandizo chanthawi yake. Vutoli limatha kuchitika chifukwa cha zovuta zomwe zimayambitsa hypoglycemia.

Mutha kuzindikira lactic acidosis ndi zizindikiro zotsatirazi:

Ngati chithandizo sichikuperekedwa panthawi, wovutikayo amagwa kukomoka ndipo amatha kufa mozizwitsa.

Momwe mungathandizire wozunzidwa ndi lactic acidosis? Kuchotsa mankhwala mwachangu ndi kuchipatala. M'mbuyomu, adayesa kuti athetse vuto la kulowetsedwa kwa sodium bicarbonate, koma panali zovuta kuchokera pamsuzi. Tsopano chithandizo chotere sichimagwiritsidwa ntchito.

Kodi ndizotheka kusintha mankhwalawo

Ngati wodwala ali ndi contraindication kapena mankhwalawo si woyenera pazifukwa zina, muyenera kusankha choloweza m'malo. Ngati tsankho siliri lalikulu, mutha kumwa mankhwalawo motengera metformin, koma kuchokera kwa wopanga wina (mwachidziwikire, woyambayo). Kupatula apo, matupi awo sagwirizana sangayambitse chisakanizo chachikulu, komanso mafayilitsi. Ndipo wopanga aliyense amakhala ndi wake.

Ofanana ndi mankhwala a Metformin antidiabetic ali ndi makina ochitira:

Zomwe zimaperekedwa kuti zidziwike pokhapokha, dokotala ayenera kusankha algorithm yatsopano.

Pamene Metformin Sikuthandizira

Pamabwalo azisangalalo, ena odwala matenda ashuga amadandaula za kusathandiza kwa mankhwalawa. Kodi ndichifukwa ninji mankhwalawa opweteka kwambiri si aliyense 100% angalipire glycemia?

Mukasanthula nkhaniyi ndikuwongolera zolakwikazo, zotsatira zake zimawonekera mofulumira.

Metformin pomanga thupi

Kwa odwala matenda ashuga, mankhwalawa ndiofunikira, amabwezeretsa kagayidwe ka lipid komwe kali ndi matenda. Ikagwiritsidwa ntchito mosalekeza, imatetezanso mitsempha ya magazi kuchokera ku shuga, kuchokera ku cholesterol yowonjezereka ndi kuchepa kwamafuta.Koma thupi la othamanga lili ndi mitundu yosiyanasiyana yosiyanasiyana yofanana, ndipo poyanika mankhwalawo amagwiritsidwa ntchito pamaphunziro ochepa.

Ngati mukupita kukalandira mankhwala popanda mankhwala enaake, ndizovuta kuyendera pamalowo: m'malo mwa Metformin, mudzapatsidwa Metfogamma, Bagomet, Siofor, Novoformin, Glyukofazh, Diaformin, Orabet, ... Mankhwalawa ali ndi mankhwala omwe amagwiritsidwa ntchito kale - Metformin. Mlingo, komanso nthawi ya zochitika, ndizosiyana. Yoyenera kusankha? Chachikulu ndikuyimilira pachinthu chimodzi ndikuchigwiritsa ntchito mpaka kumapeto kwa maphunzirowo.

Metformin imachirikiza kuchuluka kwa shuga poletsa chakudya chamafuta m'mimba ndikulepheretsa kupanga glycogen m'chiwindi. Thupi limakhala loperewera mphamvu ndipo limayenera kugwiritsa ntchito mafuta ake omwe. Mofananamo, mankhwalawa samabweretsa thupi ku hypoglycemia, chifukwa chake, ngakhale pakudya, othamanga sakhala ndi vuto losafuna kudya.

Mankhwalawo pawokha samawotcha mafuta, koma mafuta ochulukirapo amachoka. Ichi ndi chifukwa cha kukhoza kwa mankhwalawa kuti muchepetse kukana kwa insulini - woyang'anira wamkulu wa kagayidwe kachakudya, owongolera anjala komanso njira yopangira mafuta. Ndipo mafuta ochepera amayikidwa, ocheperako nthawi zambiri amakhala ndi chidwi chokhala pansi ndipo mafuta osungunuka amasungunuka kwambiri.

Aliyense amene amagwiritsa ntchito Metformin kuti achepetse thupi, muyenera kutsatira malamulo kuti mupewe zovuta zowopsa. Mlingo umodzi (500 - 850 mg) umadyedwa ndi chakudya kapena pambuyo awiri kapena katatu patsiku, kumene - mpaka miyezi itatu. Ndikofunikira kuchepetsa zakudya zamagulu a shuga komanso zakudya zamafuta othamanga kuti mupewe mavuto. Kuchuluka kwa zakumwa zakumwa ziyenera kukhala 30 ml pa 1 kg wolemera. Tiyenera kudziwa kuti

Metformin ndi mowa ndizosagwirizana kwathunthu!

Kumayambiriro kwa maphunzirowa, othamanga amakhala ndi zofanana ndi toxosis ya amayi apakati: nseru, kuchepa kwa chakudya, kusintha kwa kukoma komwe kumadza chifukwa chosowa chakudya. Kusakhudzika kumadutsa pakokha kapena pambuyo pa kusintha kwa mlingo. Ndikofunika kuti tisafe ndi njala! Ndi matenda a chiwindi ndi impso, ndibwino kuti musayesere kuwonda.

Mndandanda wathunthu wa contraindication wa Metformin uli mu malangizo a boma kuti mugwiritse ntchito. Simungamwe zakumwa zowonjezera mothandizidwa ndi diuretiki kapena mankhwala ofewetsa tuvi tofanana ndi izo - chiwopsezo cha kuvulaza impso ukuwonjezeka.

Werengani zambiri za kugwiritsidwa ntchito kwa Metformin pamasewera - pa chidziwitso cha masewera pa SPORT SCIENCE

Kodi ndikofunika kuchepetsa thupi ndi metformin

Pofunafuna chithunzi choyenera, chomwe sitikugwiritsa ntchito, ngakhale njirayo ikukayikira, komanso mapiritsi ambiri amavulaza thanzi. Ndikofunika kukumbukira kuti Metformin poyambirira adapangidwa kuti azilamulira matenda a shuga a 2. Pophunzira maluso ake, zidapezeka kuti zimapangitsa kunenepa kwambiri - chimodzi mwazifukwa zazikulu zopangitsa kuti matendawa azitha.

Kodi mankhwalawa amagwira ntchito bwanji ndipo kunenepa kwambiri nthawi zonse kumayenderana ndi kudya kwambiri? Madokotala amatsimikizira kuti mu 99% ya milandu, anthu onenepa amakula insulin. Ntchito ya insulin ndikutsatira glucose m'maselo. Mu kapisozi wamafuta m'maselo, chidwi chake chimachepa, ndipo mamolekyule "okoma" samalowa. Zotsatira zake, kapamba amalandila chizindikiro kuchokera ku b-cell kuti tifulumizitse kaphatikizidwe ka insulin, ndi mitundu yake yowonjezera m'magazi. Izi zimabweretsa vuto la lipid metabolism, popeza tsopano ndizosavuta kuphatikiza mafuta.

Pali zifukwa zambiri zomwe zimapangitsa chidwi cha maselo ku insulin kuchepa, koma chachikulu ndicho kudya kwambiri mafuta m'thupi. Maselo omwe amakhala ndi glucose amatsekedwa kuchokera ku insulin. Ndipo kuchuluka kwa mahomoni akuchuluka m'thupi, kumakhala kosavuta kwa iye. Zotsatira za kuzungulira koipa kumeneku kumakhala kunenepa kwambiri, kukana insulini komanso hyperinsulinism.

Mankhwalawa amabwezeretsa chidwi cham'magazi ndikubwezeretsanso mahomoni. Glucose nthawi zambiri imalowa, insulin imapangidwa nthawi zambiri, sizithandiza kuti pakhale mafuta.

Mankhwalawa ali ndi osadziwika concomitant zotsatira - anorexigenic. Ndi zomwe aliyense amafunikira akagula mankhwala ndi cholinga chongofuna kuchepetsa thupi. Koma mankhwalawa amachepetsa kudya pang'ono ndipo samathandiza aliyense.

Malangizo ochepetsa thupi pa Metformin

Palibe piritsi yamatsenga yomwe imawotcha mafuta mwachangu pomwe mukumangiriza bun ina pa TV.

Popanda kusintha kosinthika (zakudya zochepa za carb, zochitika zolimbitsa thupi, zachilengedwe zamaganizidwe), zotsatira zomwe mukufuna sizikhala.

Mwakutero, mutha kuchepetsa thupi popanda Metformin, popeza kutsimikizika kwakukulu ndikadali ndi moyo wathanzi. Chenjezo ili silikugwira ntchito kwa odwala matenda ashuga omwe ali ndi kunenepa kwambiri. Koma ngati atsikana athanzi amakhala omasuka kuchepera thupi ndi mapiritsi, muyenera kuchita molondola.

Mutha kugula ma analogue a Metformin, kampani iliyonse yamankhwala imapangira pansi pa dzina lake kapena kuwonjezera chiwonetsero choyambirira: Teva, Canon, Richter. Makapisozi amasiyana mu kapangidwe ka zigobazi komanso mafilimu. Ndi omwe nthawi zambiri amayambitsa ziwopsezo, ngakhale mankhwalawa ali ndi zotsutsana ndi zotsatira zoyipa, omwe ayenera kudziwa kuchepa thupi.

Yambitsani maphunzirowa ndi osachepera 500 mg, kumwa mapiritsi kamodzi. Mankhwala amapangidwa mosiyanasiyana, ngati muyamba ndi Mlingo wina, mutha kumva kuyambira masiku onse osangalala ndi zotsatira zosafunikira, makamaka matenda am'mimba. Mulingo woyenera ndi 3000 mg / tsiku, koma madokotala ambiri amalimbikitsa kuti azikhala ndi 2000 mg / tsiku.

Ndi kuchuluka kwa mankhwalawa, zotsatira za kuchepa thupi sizingalephereke, ndipo kuchuluka kwa zotsatira zosafunikira kuonjezereka.

Mankhwalawa amadyedwa pakudya kapena mutatha kudya. Mutha kutenga usiku, chiwembu choterechi ndikulangizidwanso.
Ngati zotsatira zoyipa zikuwoneka kuchokera masiku oyamba ndipo pakatha masiku 14 a kudya kawirikawiri thupi silinazolowere, mankhwalawa amafunika kuti alowe m'malo.

Maganizo a kunenepa

About Metformin, ndemanga yochepetsera thupi, makamaka, siyabwino. Omwe adakwaniritsa zotsatira zomwe amafunsa sanagwiritse ntchito mankhwalawa komanso njira zina, chifukwa chake ndizovuta kupereka lingaliro la munthu.

Marina Ndili ndi mayi wodwala matenda ashuga, zaka 3 kale pa Metformin. Mapiritsi amasungidwa mu shuga, koma sindikuwona kusintha kwake. Ndikhulupirira kuti ngati mutsatira malingaliro onse osintha chikhalidwe, ndiye kuti popanda mankhwala mungathe kuchepetsa thupi.

Oksana. Ndidayesa Metformin kuti achepetse thupi nditabereka. Amati zimaletsa chakudya. Saw mapiritsi, monga momwe akufotokozera, kuyambira ndi zochepa komanso mopitilira muyeso. Ndilibe zizindikiro zakuchipatala za mankhwalawa. Metformin sanaonenso zovuta zapadera, komanso mwayi wamafuta oyaka. Ndidatha mwezi umodzi - palibe kusintha pamakala. Zotsatira zoyipa zimakhalanso chifukwa komanso chondidziwitsa.

Metformin: ndemanga za madokotala

Albina Mansurova, wothandizira. Metformin imaperekanso zotsatira zabwino zotsitsa shuga, koma kutaya thupi kumakhala kochepa kwambiri. Ngati wina akufuna kuchotsa 20 kg yamafuta pokhapokha pamapiritsi, osatenga njira zina zowonjezera kuti muchepetse kunenepa, ndiyenera kumukhumudwitsa. Metformin ilibe mwayi wotere, kuchuluka kwake kungawerengeke ma kilogalamu ochepa.

Metformin ndi mankhwala otchuka kwambiri a matenda a shuga a 2, komanso kuwonda komanso kuchiritsa polysystosis a thumba losunga mazira mwa akazi. Imachepetsa shuga yamagazi ndikuthandizira kutaya mapaundi owonjezera osayambitsa zovuta zoyipa. Imachulukitsa moyo, imachepetsa chiopsezo cha matenda a mtima ndi sitiroko, komanso mitundu ina ya khansa. Mapiritsi awa ali ndi mtengo wotsika mtengo, chifukwa amapangidwa ndi masamba ambiri opanga mankhwala omwe amapikisana nawo.

Werengani mayankho a mafunso:

Otsatirawa ndi buku lophunzitsira lolemba m'chinenero chomveka.Dziwani zomwe zikuwonetsa, contraindication, Mlingo, komanso njira yochepetsera kuchepetsa mavuto.

Metformin yokhudza matenda ashuga komanso kuwonda: nkhani yatsatanetsatane

Werengani nawonso malingaliro oleza mtima a momwe metformin imakhudzira impso ndi chiwindi, momwe mapiritsiwo alili osiyana, ndi anzawo aku Russia.

Kodi mankhwalawa amalembedwera chiyani?

Zizindikiro zomwe zimagwiritsidwa ntchito ndi mtundu wa shuga wachiwiri, komanso mtundu wa 1 shuga, wovuta kwambiri chifukwa cha kunenepa kwambiri komanso kukana insulin. Komabe, anthu ambiri amatenga metformin kuti achepetse thupi kuposa kuchiritsa matenda ashuga. Komanso, mankhwalawa amathandizira ndi polycystic ovary syndrome (PCOS) mwa amayi, amawonjezera mwayi wokhala ndi pakati. Kugwiritsa ntchito metformin pakuchepetsa thupi komanso kuwongolera shuga kumafotokozedwa mwatsatanetsatane pansipa.

Mutu wamankhwala a PCOS ndi woposa tsambali. Amayi omwe akumana ndi vutoli, muyenera kupita, kukachita maphunziro akuthupi, kumwa mankhwala ndikutsatira malangizowo. Kupanda kutero, adzakhala ndi mwayi wochepa wokhala ndi pakati komanso chiwopsezo chachikulu chokhala ndi matenda osokoneza bongo a 2 zaka zopitilira 35-40.

Njira zodziwika za metformin

Chofunikira kwambiri cha metformin ndikupewa kupangira shuga.

Metformin imayambitsa kutulutsidwa kwa michere ya chiwindi AMPK, yomwe imayang'anira kagayidwe kazigazi ndi mafuta. Kutsegulira uku kumabweretsa kuponderezedwa kwa kupanga kwa shuga m'chiwindi. Ndiye kuti, shuga owonjezera chifukwa cha metformin samapangidwa.

Kuphatikiza apo, metformin imakulitsa chidwi chake ndi insulin yake ndikuwonjezera kutuluka kwa glucose (pogwiritsa ntchito insulin, glucose imaperekedwa ku maselo onse amthupi ndikukhala gwero lamphamvu), imawonjezera oxidation wamafuta acids, ndikuchepetsa mayamwidwe a glucose m'matumbo am'mimba.

Kuchedwa kuyamwa kwa glucose m'matumbo am'mimba ndi metformin kumathandizira kuti shuga azikhala ochepa magazi atatha kudya, komanso kuwonjezera kukhudzidwa kwa maselo omwe akulimbana ndi insulin yawo. Katunduyu wa metformin amalola kuti agwiritsidwe ntchito prediabetes - kupewa matenda ashuga omwe amakonda.

Pambuyo pakukonzekera pakamwa, metformin imalowa m'matumbo am'mimba, kugwira kwake ntchito kumayamba pambuyo pa maola 2,5. Ndipo metformin imachotsedwanso ndi impso patatha pafupifupi maola 9-12. Tiyenera kudziwa kuti metformin imatha kudzikundikira m'chiwindi, impso ndi minofu.

Kugwiritsa ntchito metformin kumayamba ndi kudya kwa 500-850 mg katatu patsiku pakudya kapena mutatha kudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatheka kutengera zotsatira zamagazi pamagazi.

Njira yokonzanso metformin nthawi zambiri imakhala 1500-2000 mg / tsiku.

Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku umagawidwa mu Mlingo wa 2-3. Pazipita tsiku mlingo 3000 mg / tsiku, ogaŵikana 3 waukulu.

Mankhwala oyamba a metformin ndi French Glucophage.

Jenereta ya Glucophage: Metformin ya kampani Ozone (Russia), Siofor, etc.

Komabe, kuti muchepetse zotsatira zoyipa za metformin (m'matumbo am'mimba) ndikusintha moyo wa odwala omwe ali ndi matenda amtundu wa 2 ku France, metformin yomwe idatenga nthawi yayitali idapangidwa ndikumasulidwa pansi pa dzina la Glucofage Long pang'onopang'ono kulowetsedwa kwa metformin yogwira ntchito. Glucophage yayitali imatha kutengedwa kamodzi patsiku, zomwe, ndizosavuta kwa odwala.

Mafuta a metformin omwe amakhala nthawi yayitali ali m'matumbo am'mimba.

Katundu wapadera ndi kugwiritsidwa ntchito kwatsopano kwa metformin

Metformin ikuphunziridwa m'maiko ambiri: intaneti yadzaza ndi mauthenga okhudza zinthu zomwe zapezeka kumene. Chifukwa chake, kodi kugwiritsa ntchito metformin ndi machenjezo lero ndi otani?

1. Metformin imaletsa ndikuwongolera matenda ashuga a 2.
2. Metformin samachepetsa shuga mutangomwa muyezo woyamba.Kuchita kwake kumayamba pambuyo pa maola 2,5. Kutsika kwa shuga m'magazi kumachitika m'masiku ochepa - kuyambira masiku 7 mpaka 14.
3. Sichimayambitsa hypoglycemia mu mankhwala othandizira, ali ndi bongo - osowa kwambiri.
4. Metformin ikhoza kuphatikizidwa ndi insulin, maninil, etc.
5. Dr. R. Bernstein (USA) akuti metformin imachepetsa chiwopsezo cha khansa, komanso imachepetsa mahomoni am'malo amanjala, potero amathandizira kukhazikika kwamphamvu.
6. Malinga ndi kafukufuku wa Craig Kerry, metformin itha kugwiritsidwa ntchito bwino povuta pa matenda a oncology ndi mtima.
7. Metformin imalimbikitsa kukula kwa ma neuron atsopano muubongo ndi chingwe cha msana.
8. Mu matenda a Alzheimer's, kuchuluka kwamaselo am'mitsempha mwanga mu hippocampus, gawo laubongo momwe zikumbukiro zatsopano zimachepa kwambiri. Zochitika zimawonetsa kuti kutenga 1000 mg ya metformin patsiku kwa anthu olemera 60 makilogalamu kumawongolera kwambiri luso lotha kukumbukira zina zatsopano.
9. Pali malingaliro osiyana akuti metformin palokha imachulukitsa chiopsezo cha matenda a dementia. Ofufuza ku Taiwan otsogozedwa ndi Dr. Yichun Kuan adachita kafukufuku wa odwala 9300 omwe ali ndi matenda amtundu wa 2, ndikuwunika mphamvu ya metformin pagulu lolamulira la odwala. Mapeto awo: wodwalayo akamatenga metformin komanso kukulitsa mlingo, ndiye kuti ali ndi vuto lakelo. Malingaliro awa amafunsidwa ndi akatswiri ambiri.
10. Metformin imachepetsa kutupa kwamtundu - chimodzi mwazomwe zimayambitsa kukalamba, imateteza mtima ndi mitsempha yamagazi kukalamba.
11. Mankhwala amasintha cholesterol, kutsitsa kiwango cha otsika-kachulukidwe kolesterol.
12. Metformin imachepetsa kuchuluka kwa ma enzymes a chiwindi ndipo imatha kuchiza matenda osagwirizana ndi mafuta a chiwindi odwala omwe ali ndi matenda ashuga.
13. Amachepetsa chiopsezo chaimfa kuchokera kumaluwa a zovuta za matenda ashuga pafupi 30%.
14. Metformin ilibe zotsutsana kwambiri pamatenda a impso, chiwindi, komanso kulephera kwamtima kosatha. Ngati alipo, adokotala amasintha mlingo, ndipo wodwalayo akupitilizabe kugwiritsa ntchito metformin. Komabe, lingaliro la adokotala ndi zovuta zamtima, chiwindi ndi impso za wodwalayo mwina sizingakhale bwino kuti amwe mankhwalawa.
15. Metformin imatha kuchepetsa kuchuluka kwa vitamini B12, chifukwa chake mukamagwiritsa ntchito, muyenera kuwunika kuchuluka kwa magazi.
16. Chimagwiritsidwa ntchito pakalibe ovulation mu osabereka odwala.
17. Metformin imakhazikitsa kulemera panthawi yomwe imayambitsidwa ndi antipsychotic mankhwala.
18. Sungaphatikizidwe ndi mowa kuti mupewe zovuta zamtundu wa lactic acidosis (zovuta zakupha).
19. Metformin ndi woyimira kukhala wowachiritsa ku ukalamba.
20. Ikuphunziridwa ngati mankhwala omwe angathe kuchitira mankhwalawa kwa odwala matenda amisempha.

Kuchokera pamndandandawu, kugwiritsidwa ntchito kwatsopano kwa metformin (kupatula mtundu wa 2 matenda ashuga) komwe kunafufuzidwa ndi asayansi kukuwunikidwa. Pofuna chilungamo, ziyenera kunenedwa kuti zambiri mwazomwe zikugwiritsidwa ntchitozi zikutsutsa ntchito ya ofufuza ena. Chifukwa chake, akatswiri akadatsutsanabe ngati Metformin amachepetsa kulemera kapena ayi. Ntchito zina zimawonetsa kukopa bwino kwa ovulation ndi metformin, pomwe ena amafotokoza zovuta zazing'ono za mankhwalawa pakubala.

Wopanga zamasamba Sorokina Vera Vladimirovna

Zaka zaposachedwa, asayansi afika pakukhulupirira kuti ukalamba ndi matenda chabe omwe amatha kuchiritsidwa. Mankhwala aliwonse a pharmacological amapita kafukufuku osati pazomwe amafuna, komanso pa anti-kukalamba. Pali mankhwala ambiri padziko lapansi omwe amatha kutalikitsa moyo wa munthu, ndipo imodzi mwa izo ndi Metformin, yopangidwa ndi asayansi aku Russia zaka zoposa 60 zapitazo. Ndiye kodi imatenga nthawi yayitali bwanji?

Chithandizo chogwira mankhwalawa ndi metformin hydrochloride, yomwe imapangitsa kuchepetsa kukalamba kwa munthu. Metformin poyambilira anafuna kuchiritsa matenda ashuga amtundu wa 2.Zinapezeka ndi asayansi aku Russia zaka 60 zapitazo. Kuyambira pamenepo, zambiri zalandiridwa pokhudzana ndi njira zake zothandizira pochiritsa. Anthu omwe ali ndi matenda ashuga omwe amamwa mankhwala a metformin amakhala 25% motalikirapo kuposa omwe alibe matendawa. Izi zimapangitsa asayansi kuphunzira mankhwalawa ngati njira yotalikitsira moyo. Masiku ano, maphunziro angapo a metformin ngati mankhwala ochiritsira okalamba akuchitika padziko lonse lapansi. Makamaka, mu 2005 ku Oncology Research Institute yotchedwa N.N. Petrova, kafukufuku adachitika mu labotale kuti aphunzire za ukalamba ndi carcinogenesis, zomwe zimawonetsa kuti metformin imatalikitsa moyo. Zowona, kuyesaku kunachitika kokha pa nyama. Kuphatikizanso kwina, chifukwa cha kafukufukuyu, kudapeza kuti chinthucho chimatetezanso nyama ku khansa. Pambuyo pa kafukufukuyu, gulu lonse la asayansi padziko lonse lapansi lidachita chidwi ndi zochita za metformin. Kuchokera nthawi imeneyo, kafukufuku wambiri wachitika omwe amatsimikizira zotsatira za kuyesa kwa 2005. Mu malangizo ogwiritsira ntchito, simukuwona mawu omwe akuwonetsa mphamvu ya mankhwalawa pakukulitsa moyo. Koma, izi zimachitika kokha chifukwa chakuti ukalamba mwalamulo sunazindikiridwe ngati matenda. Kodi metformin imakhudza bwanji thupi? Kutulutsidwa kwamitsempha yamagazi kuchokera ku cholesterol plaques. Izi zimabweretsa kuti ntchito yofananira ya kuzungulira kwa dongosolo, imalepheretsa thrombosis ndi vasoconstriction. Mphamvu iyi ya mankhwalawa imathandizira kukulitsa unyamata wamtima mu mtima. Amadziwika kuti kuchuluka kwakukulu kwaimfa kumachitika chifukwa cha matenda amdongosolo lino.

Kuwongolera kagayidwe kake ndikuwonjezera kuchuluka kwa cholesterol yopindulitsa ndikuchepetsa kuvulaza. Momwemo, pali kagayidwe koyenera m'thupi. Mafuta amamwetsedwa molondola, pamakhala pang'onopang'ono, osautsa, wotaya mafuta owonjezera ndi kulemera. Zotsatira zake, katundu pamakina onse ofunikira amachepetsedwa. Ngati, nthawi yomweyo akamamwa mankhwalawo, munthu amayamba kusintha moyo wake, zotsatira za mankhwalawo zimawonjezeka. Anachepetsa chilako. Chinsinsi cha moyo wautali ndi kuwonda. Izi ndiye zowona. Metformin imathandizira kukwaniritsa ntchito iyi mwa kupondereza chilakolako chofuna kudya. Kuchotsa shuga m'magazi am'mimba. Kutha kwa shuga kuthamangitsa njira zogwirizanirana zama mamolekyulu a protein kumathandizira kukalamba msanga komanso kumatenda ambiri. Kuwongolera magazi. Kuchita izi kumachepetsa chiwopsezo cha kuundana kwa magazi, sitiroko komanso mtima. Matendawa akutsogolera mndandanda wazomwe zimayambitsa kufa msanga. Kuphatikizika kwa mankhwalawa ndi lilac, muzu wa mbuzi, talc, magnesium stearate, wowuma, titanium dioxide, crospovidone, povidone K90, macrogol 6000. Chofunikira chachikulu pakuphatikizira mu mankhwalawa ndi metformin hydrochloride, yopangidwa kuchokera ku zinthu zachilengedwe zachilengedwe: lilac ndi muzu wa mbuzi. Komanso, mankhwalawa ali ndi zovuta zina zowonjezera, makamaka talc, magnesium stearate, titanium dioxide ndi omwe adalembedwa pamwambapa. Malangizo a kumwa mankhwalawa Kuti mugwiritse ntchito metformin kuti muchepetse kukalamba, muyenera kumwa mankhwalawa pa theka la mankhwalawo omwe akupezeka mu malangizo ogwiritsira ntchito. Mlingo wa mankhwala amaperekedwa pochiza matenda ashuga ndi matenda ena. Koma, munthu wathanzi akamagwiritsa ntchito mankhwala amenewa, amatha kuvulaza kuposa zabwino. Zofunika! Musanaganize zogwiritsira ntchito metformin, kuunika kwathunthu ndikofunikira. Izi ndizofunikira kuti muchepetse chiopsezo cha zotsatira zoyipa ndikuzindikira mtundu wa prophylactic. Kugwiritsa ntchito mankhwalawa ngati anti-okalamba, mfundo zotsatirazi ziyenera kukumbukiridwa: zaka siziyenera kukhala zosaposa zaka 30, koma osapitirira 60, kunenepa kwambiri komanso kunenepa kwambiri, kuchuluka kwa cholesterol ndi / kapena shuga ndizoposa kwazonse. Mlingo woyenera uyenera kuthandizidwa ndi dokotala ndikufotokozera momwe mungagwiritsire metformin.Kuti mumve, tikulimbikitsidwa kuti musatenge oposa 250 mg a metformin patsiku. Ndi metformin iti yomwe ndiyabwino kupangidwanso? Metformin imapangidwa pansi pa malonda osiyanasiyana ndipo imapangidwa ndi makampani ambiri: Metformin, Glycon, Metospanin, Siofor, Glyukofag, Glyformin ndi ena.

Axamwali! Lero tikulankhula za kukalamba, kapena, momwe tingachedwetsere. Zidapezeka kuti pali machiritso okalamba! Awa ndi Metformin, mapiritsi otsika mtengo omwe mungagule ku pharmacy iliyonse! Mmodzi “Koma”! Dokotala wanu ayenera kukupatsani mankhwala. Palibe chodzichitira nokha mankhwala!

Ukalamba ndi chikhalidwe cha munthu, koma palibe amene amafuna kuti azidwala komanso kufooka. Zizindikiro za ukalamba zomwe zimayenderana ndi nyengo ino ya moyo zimawopsa anthu ambiri ndikupangitsa chiyembekezo cha m'badwo uno kukhala chopweteka kwa ambiri.

Mbiri imadziwa nthawi zambiri pomwe anthu anzeru ndi aluso adafa mwa kufuna kwawo chifukwa sangathe kuzindikira malire omwe m'badwo umabweretsa.

Asayansi kuyambira nthawi zakale akhala akulimbana ndi vuto laukalamba, kupatula zomwe m'mbuyomu aliyense ankalota za moyo wamuyaya, kupanga zofunikira zauzimu zamuyaya kuchokera kuzomera, nyama ndi mchere mu zosakanikirana zabwino kwambiri.

Masiku ano, chikhulupiriro mu "njira yamphumphu" ya Makropoulos yopanda cholakwika ndi unyamata wamuyaya sichikhalanso wamphamvu. Asayansi akugwira ntchito yayitali kutalikitsa moyo polimbitsa thanzi lachilengedwe ndikuchotsa matenda ambiri omwe kukalamba kumalumikizana nawo.

Axamwali! Osathamangira kukalamba! Khalani achichepere m'moyo. Izi ndizofunikira kwambiri. Mverani izi:

Amakhulupirira kuti thupi la munthu "linapangidwa" kuti lizigwira ntchito kwa zaka zosachepera 100.

Komabe, zizolowezi zambiri zoyipa ndi matenda, komanso chilengedwe, zimasokoneza moyo wautali. Pakadali pano palibe amene wakwanitsa kupanga "piritsi limodzi lokalamba", lomwe lingathandize aliyense komanso aliyense, pali kale mankhwala omwe ali ndi udindo wamankhwala omwe ungachedwetse kukalamba ndikupanga kukhala wathanzi, wautali komanso wogwira ntchito.

Mankhwala Metformin amatchedwa ndipo adapangira zochizira matenda amitundu iwiri.

Zomwe zikuchitika pa Metformin

Metformin si machiritso okalamba mu tanthauzo lenileni la liwulo. Onetsetsani kuti mukuonera kanema pansipa! Mvetsetsani kwambiri.

Matenda a shuga ayamba kufalikira masiku ano, popeza vuto lalikulu la nthawi yathu, mosadabwitsa, ndi chakudya chopanda malire. Zakudya zambiri zopatsa mphamvu kwambiri komanso zomwe zimachokera zimayambitsa maonekedwe ambiri omwe amachititsa kuti thupi lizivala koyambirira. Zotsatira zake, munthu nthawi zambiri amadwala komanso kumwalira nthawi yayitali asanakwanitse kukalamba. Malo ankhanza owopsa komanso mnzake wokhala ndi amuna amakono - kupsinjika kumathandizira kukula kwa matenda. Masiku ano, kukhala wokalamba popanda matenda ndi chisangalalo chachikulu komanso chisangalalo.

Panthawi ya mayeso a Metformin kuchipatala komanso kuwunika kwa odwala ake, madotolo ndi asayansi adazindikira kuti mankhwalawa ali ndi zochitika zambiri mokwanira kuposa momwe amangoyerekezera ndi matenda amtundu wa 2. Zimathandizira kuyeretsa m'mitsempha yama cholesterol. Izi zimamasula lumen ndikuwongolera kayendedwe ka magazi, kupewa kupezeka kwa kuchepetsa ndi thrombosis. Zida zathanzi ndizopewera matenda a mtima wamunthu, makamaka matenda a mtima ndi stroko. Ndizodwala zomwe zimayambitsa kuchuluka kwakukulu kwa anthu omwe amafa pasadakhale kapena kupezeka kwa matenda opunduka ndi olumala.

Chifukwa chakuchita bwino kwa kayendedwe ka magazi, Metformin imakhudzanso kagayidwe. Popeza kuchuluka kwa cholesterol “yoyipa” kumachepa, ndipo cholesterol yabwino "imakwera, njira zonse za metabolic mthupi, makamaka zomwe zimakhudzana ndi mayamwidwe amafuta, zimasinthidwa.Wodwala bwino komanso mopweteketsa thupi amachepetsa thupi, ndipo kuchepa thupi ndiko njira yothandizira machiritso amthupi mu 99.9% yamilandu. Kuchepetsa thupi kumachepetsa katundu pa minofu ya mtima, kupuma komanso matumbo, kumathandizira kugwira ntchito kwa minofu ndi mafupa. Ngati panthawiyi munthu asankha kuthandiza thupi lake ndikusinthira kudya mokwanira komanso kusamala, kusuntha kwambiri, kusewera masewera ndikukhala ndi moyo wotakataka, adzakhala ndi mwayi wopitiliza kukhala ndi moyo wautali, wokwanira komanso wathanzi.

Metformin - kapangidwe ndi cholinga chake

Metformin ndi piritsi yokonzekera kutsitsa shuga wamagazi, omwe amagwiritsidwa ntchito ngati matenda a shuga a 2. Zimathandizira kuchepetsa kuyamwa kwa glucose komanso kutulutsa kwake bwino. Kuchepetsa kuchuluka kwa mafuta amitundu yosiyanasiyana m'magazi, kumathandizira kuchepetsa thupi komanso kukhazikika kwake. Imalekeredwa bwino ndi thupi, imawonjezera chidwi cha minofu kuti insulin.

Mlingo wa Metformin

Ngakhale lingaliro lokopa likuchepetsa bwanji kukalamba mwa kumwa mapiritsi, simuyenera kuona chida ichi kukhala panacea ndi mankhwala osavulaza konse. Kuikidwiratu kwa Metformin kumachitika kokha ndi dokotala mu mlingo wa munthu aliyense wodwala. Kudziyendetsa nokha popanda kuyang'aniridwa ndi akatswiri kungakhale koopsa komanso koopsa.

Mukamatenga Metformin, pali malingaliro ena.

1. Piritsi limamezedwa lonse, osafuna kutafuna, popeza limakutidwa ndi membala wapadera womwe umasungunuka m'mimba, ndikutsegulira mwayi wopezeka pazomwe zimagwira.
2. Imwani mankhwalawa ndi madzi okwanira.
3. Analimbikitsa kudya ndi zakudya.
4. Mukamamwa, muyenera kuonetsetsa kuti palibe fiber kapena ma coarse zakudya m'zakudya nthawi yomweyo momwe mankhwalawo amwedwa, popeza chakudya choterechi chithandiza kuchepetsa kuperewera kwa theka ndi mankhwalawo.
5. Kudya kowonjezereka kwa vitamini B12 kumafunikiranso, komwe kungasowe chifukwa cha zochita za Metformin pa lipids.

Mlingo wa mavitamini ndi mawonekedwe a makonzedwe amayikidwa ndi adokotala, potengera kuwunika kwa wodwala wina ndi momwe alili wathanzi.

Popeza kuti mankhwala aliwonse amatha kuvulaza thupi ngati atengedwa mosasamala, ngakhale mavitamini wamba, simuyenera kuyeserera.

Pambuyo pofufuza mosamalitsa katswiri wabwino amatha kudziwa mankhwalawa chifukwa chosagwirizana. Ndikofunikanso kwambiri kuti musasinthe mlingo woyeserera ndikugwiritsa ntchito mankhwalawo panthawi yoyenera.

Pomaliza, titha kunena kuti mankhwalawa ndi chizindikiro chokhacho mndandanda wamtsogolo wazinthu zomwe zikupangidwa kale m'malo opangira mankhwala. Amapangidwa kuti apulumutse umunthu ku matenda ambiri ndikupangitsa kukalamba osati mkhalidwe wamavuto osatha azaumoyo ndi zofooka, koma nthawi yakukula kwa malingaliro ndi thupi.

Wokondedwa owerenga! Ndikutsimikiza kuti sikuti Metformin yekha, komanso Chikondi ndi anti-okalamba.

Vomerezani kuti pamene wina akufuna munthu, pomwe akumukumbukira ndikumukonda, iye ali moyo. Okondedwa, kondani ndikukhala ndi moyo wautali!

Kuphatikizika kwa mankhwalawa kumakhala ndi gawo lina lake metforminkomanso zinthu zina zowonjezera: wowuma, magnesium stearate, talc.

Kukonzanso mphamvu ya kumwa mankhwala

Kutsutsa-kukalamba kwa mankhwalawa kwatchulidwa posachedwa. Poyamba, mankhwalawa amapangidwa ngati mankhwala a hypoglycemic pochiza matenda osokoneza bongo omwe amadalira insulin.

Mankhwalawa adapezeka ndi asayansi aku Russia pafupifupi zaka makumi asanu ndi limodzi zapitazo. Mu zaka zonsezi, mayesero osiyanasiyana azachipatala akhala akuchitika, omwe akuwonetsa mwayi wogwiritsa ntchito mankhwalawa osati panthawi ya matenda ashuga okha.Malinga ndi ziwerengero zamankhwala, odwala matenda ashuga omwe adalandira njira yochizira pogwiritsa ntchito metformin hydrochloride amakhala pafupifupi kotala kuposa anthu osazindikira. Ndiye chifukwa chake, asayansi adaganiza zowerengera mankhwalawa ngati mankhwala othana ndi ukalamba.

Zaka zingapo zapitazo, kafukufuku wasayansi adachitika ku Petrov Research Institute, omwe adawonetsa kuti metformin sikuti ndimachiritso aukalamba kokha, koma chitetezo mwa mawonekedwe a khansa. Mukamamwa mankhwalawa, chiopsezo chotenga khansa chimachepa 25 mpaka 40 peresenti.

Malangizo ogwiritsira ntchito mankhwalawa samawonetsa izi. Mwina izi zikuchitika chifukwa choti ukalamba wa thupi la munthu umawonedwa ngati njira yabwino yamoyo, osati matenda.

Zotsatira zotsutsa kukalamba chifukwa chotenga metformin zimawonedwa monga:

• kumasulidwa kwamitsempha yamagazi kuchokera ku cholesterol plaques, omwe akuwonetsa kukalamba kwa mtima wam'magazi, motero kusintha kayendedwe kazinthu, kochotsa chiopsezo cha thrombosis komanso kuchepetsedwa kwa lumen ya ziwiya.
• imasintha njira ya kagayidwe kachakudya mthupi, imachepetsa chilimbikitso, monga kuchepa thupi pang'ono komanso kunenepa kwambiri, kumachepetsa katundu pa ntchito ya ziwalo zonse zofunika komanso machitidwe,
• Kutha kuchepetsa kuyamwa kwa glucose kuchokera m'mimba. Inde, ukalamba usanachitike, monga momwe amadziwira, umathandizidwa ndi shuga omwe amabwera kuti azidzidzimutsa njira zomwe zimagwirira ntchito zomanga thupi,

Kuphatikiza apo, kugwiritsa ntchito Metformin kumathandizira kuti magazi azituluka.

Axamwali! Lero tikulankhula za kukalamba, kapena, momwe tingachedwetsere. Zidapezeka kuti pali machiritso okalamba! Awa ndi Metformin, mapiritsi otsika mtengo omwe mungagule ku pharmacy iliyonse! Mmodzi “Koma”! Dokotala wanu ayenera kukupatsani mankhwala. Palibe chodzichitira nokha mankhwala!

Ukalamba ndi chikhalidwe cha munthu, koma palibe amene amafuna kuti azidwala komanso kufooka. Zizindikiro za ukalamba zomwe zimayenderana ndi nyengo ino ya moyo zimawopsa anthu ambiri ndikupangitsa chiyembekezo cha m'badwo uno kukhala chopweteka kwa ambiri.

Mbiri imadziwa nthawi zambiri pomwe anthu anzeru ndi aluso adafa mwa kufuna kwawo chifukwa sangathe kuzindikira malire omwe m'badwo umabweretsa.

Asayansi kuyambira nthawi zakale akhala akulimbana ndi vuto laukalamba, kupatula zomwe m'mbuyomu aliyense ankalota za moyo wamuyaya, kupanga zofunikira zauzimu zamuyaya kuchokera kuzomera, nyama ndi mchere mu zosakanikirana zabwino kwambiri.

Masiku ano, chikhulupiriro mu "njira yamphumphu" ya Makropoulos yopanda cholakwika ndi unyamata wamuyaya sichikhalanso wamphamvu. Asayansi akugwira ntchito yayitali kutalikitsa moyo polimbitsa thanzi lachilengedwe ndikuchotsa matenda ambiri omwe kukalamba kumalumikizana nawo.

Axamwali! Osathamangira kukalamba! Khalani achichepere m'moyo. Izi ndizofunikira kwambiri. Mverani izi:

Amakhulupirira kuti thupi la munthu "linapangidwa" kuti lizigwira ntchito kwa zaka zosachepera 100.

Komabe, zizolowezi zambiri zoyipa ndi matenda, komanso chilengedwe, zimasokoneza moyo wautali. Pakadali pano palibe amene wakwanitsa kupanga "piritsi limodzi lokalamba", lomwe lingathandize aliyense komanso aliyense, pali kale mankhwala omwe ali ndi udindo wamankhwala omwe ungachedwetse kukalamba ndikupanga kukhala wathanzi, wautali komanso wogwira ntchito.

Mankhwala Metformin amatchedwa ndipo adapangira zochizira matenda amitundu iwiri.

Kugwiritsa ntchito metformin ngati othandizira kukalamba

Madokotala ndi asayansi amakono amakhulupirira kuti Metformin ikhoza kukhala njira imodzi yomwe ingakhudzire ukalamba wa munthu. Izi si “zozizira” zenizeni mumkhalidwe wachinyamata wokhazikika, popeza mapiritsi amatsenga kulibe, ndipo ndiye kuti sizingatheke konse kuti apangidwe.Komabe, Metformin imathandizira kuchepetsa chiwopsezo cha khansa, imalimbitsa minofu yamtima, imayendetsa magazi mwachizolowezi ku ubongo ndikusunga thanzi labwino mpaka ukalamba.

Popeza kuti masiku ano, kufa msanga kwa ana chifukwa cha kuwonongeka kwa mtima, ndiye kuti mankhwalawa atha kudziwikanso ngati machiritso okalamba. Chowonadi ndi chakuti vuto lalikulu lamitsempha yamagazi ndi atherosulinosis, ndiko kuti, kufupika kwa lumen ya chotengera chifukwa cha kuchuluka kwa zolembedwa za cholesterol. Kenako, cholesterol yochulukirapo m'thupi imalumikizidwa ndi kusokonezeka kwa dongosolo logaya chakudya m'mimba ndi zovuta za chitetezo cha m'thupi, kugwira ntchito kwa kapamba ndi mavuto akulu a metabolic. Ndipo izi zimakwiyitsidwa ndi kunenepa kwambiri komanso kunenepa kwambiri.

Cholinga chodzikundikira mafuta owonjezera amawonedwa kuti ndi osayenera komanso zakudya zopatsa thanzi kwambiri. Inde, zili choncho, koma kwenikweni vutoli ndi lalikulu. Kudyetsa pafupifupi 30% kuchuluka kwa zopatsa mphamvu ndizofunikira masiku ano. Koma kumangokhala ndi moyo wolumikizana kumathandizanso kunenepa kwambiri, ndipo kusachita zolimbitsa thupi kumakulitsa vuto la kudya kwambiri ndi vuto la mtima komanso minyewa yolimba. Kusasunthika kwa magazi ndi zamitsempha zimathandizira kukulitsa mavuto ndi mitsempha ya magazi, ndipo cholesterol yowonjezera "yoyipa" imathetseratu thanzi la mtima. Vutoli limakulirakulira chifukwa cha kupsinjika komwe kumathandizira "kuzama" kwamtima ndi m'mitsempha yamagazi. Zotsatira zake - matenda ashuga, mtima, matumbo am'mimba, matenda am'mimba, stroko, kugunda kwa mtima, kufa msanga.

Metformin sikuwoneka ngati yogwirizana kwambiri ndi ukalamba ndi matenda a mtima. Samachiritsa mavuto omwe alipo, koma amayamba kukhudza thupi, kunena kwake, kuchokera kotsika kwambiri. Mankhwalawa amathandizira pang'onopang'ono kusintha kwa kagayidwe, kayendedwe ka mafuta kagayidwe kake komanso kuyamwa koyenera kwa glucose, komwe kumapangitsa kuti thupi lichepe. Liwu lofunikira kwambiri apa ndi kuchepetsa, kuwonda pang'onopang'ono. Mankhwalawa amagwira ntchito ngakhale pamene zakudya zotsatsira "zosavomerezeka" sizikugwirizana konse. Kuchepetsa thupi kwambiri kumakhala kupsinjika kwambiri kwa thupi, komwe kumatha kuwononga thanzi, komanso ngakhale kuyambitsa matenda. Metformin imaperekanso kuchepa thupi kwakuthupi, osati kungovulaza kokha, komanso thanzi labwino kwambiri.

Mothandizidwa ndi Metformin, mndandanda wa zochita zabwino zotsatizana ungatsatidwe: kupangitsa kuti mafuta azikhala ndi kuchuluka kwa glucose kumabweretsa kukhazikitsidwa kwa cholesterol moyenera, pamene cholesterol "yoyipa" itachepa komanso cholesterol yothandiza ikukwera. Gawo lotsatira ndi kuyeretsa kwamitsempha yamagazi kuchokera ku cholesterol plaque, komwe kumabweretsa kusintha kwina mu kayendedwe ka magazi mthupi ndi ubongo makamaka. Izi zimayambitsa kusintha kwamtundu wa makulidwe, kukula kwa ntchito zamaganizo ndikuletsa kukalamba kwa chiwalochi. Zotsatira zake, munthu kwa zaka zambiri amakhalabe woganiza bwino komanso wogwira ntchito, mwakutalikitsa amakhala ndi moyo wopindulitsa.

Kupititsa patsogolo magazi kumakhala ndi zotsatira zabwino pa ntchito ya mtima. Zombo zoyeretsedwa zimathandizira kukhalabe wathanzi la chiwalo chofunikira ichi komanso zimachepetsa kwambiri chiopsezo chowopsa cha mtima, matenda amitsempha yamagazi, komanso kulowetsedwa kwam'mnyewa. Mtima wamphamvu komanso wolimba, umakhala ndi mwayi wokhala ndi moyo wautali komanso wathanzi.

Kodi Metformin Ikulitsa Moyo?

Metformin imachulukitsa moyo wa odwala omwe ali ndi matenda a shuga a 2, amachedwa kukulitsa zovuta zawo. Sizinatsimikiziridwebe kale kuti mankhwalawa amathandiza anthu athanzi ndi shuga wabwinobwino wamagazi kuyambira kukalamba. Kafukufuku wovuta pankhaniyi wayamba kale, koma zotsatira zake sizipezeka posachedwa. Komabe, anthu ambiri odziwika ku West adavomereza kuti amavomereza, kuyesera kuti achepetse ukalamba wawo.Adasankha kuti asadikire chitsimikiziro chovomerezeka.

Dokotala wodziwika komanso wowonetsa TV pa TV Elena Malysheva amalimbikitsanso kuti mankhwalawa ndi mankhwala ngati ukalamba.

Oyang'anira tsambali amaganizira za chiphunzitso cholimbikitsa chakuti metformin imachepetsa ukalamba, makamaka kwa anthu onenepa kwambiri. Elena Malysheva nthawi zambiri amafalitsa zinthu zolakwika kapena zachikale. Mankhwala omwe amawauza omwe samalankhula sawathandiza konse. Koma pankhani ya metformin, munthu angavomereze naye. Ichi ndi mankhwala othandiza kwambiri, ndipo popanda zovuta zoyipa, ngati mulibe zotsutsana nawo.

Kodi metformin ingatengedwe kuti ipewe? Ngati ndi choncho, mu milingo iti?

Ngati muli ndi kulemera pang'ono pang'ono, ndizomveka kutenga metformin kuti mupewe, kuyambira zaka zapakati. Mankhwalawa athandizira kuchepa makilogalamu ochepa, kusintha mafuta m'thupi, komanso kuchepetsa ngozi ya matenda ashuga a 2.

Musanayambe kumwa mapiritsi awa, phunzirani mosamala, makamaka magawo pazinthu zotsutsana ndi zoyipa.

Palibe deta yeniyeni pazaka zomwe mungayambe kutenga metformin. Mwachitsanzo, zaka 35 mpaka 40. Kumbukirani kuti chithandizo chachikulu ndi ichi. Mapiritsi aliwonse, ngakhale okwera mtengo kwambiri, amatha kungoonjezera zomwe chakudya chimakhala nacho mthupi lanu. Zakudya zoziziritsa kukhosi ndizowopsa. Palibe mankhwala oyipa omwe angabwezeretse zotsatira zawo zoyipa.

Anthu onenepa amalangizidwa kuti pang'onopang'ono abweretse kuchuluka kwa tsiku ndi tsiku - 2550 mg patsiku kwa mankhwala omwe amapezeka nthawi zonse ndi 2000 mg kwa mapiritsi otulutsidwa (ndi ma analogues). Yambani kumwa 500-850 mg patsiku ndipo musathamangire kuti muwonjezere mlingo kuti thupi likhale ndi nthawi yosinthira.

Tiyerekeze kuti mulibe kulemera kwambiri konse, koma mukufuna kutenga metformin kuti mupewe kusintha komwe kumayenderana ndi zaka. Pankhaniyi, sibwino kugwiritsa ntchito muyeso wokwanira. Yesani 500-1700 mg patsiku. Tsoka ilo, palibe chidziwitso chokwanira pamiyeso yolimbana ndi kukalamba ya anthu ochepa thupi.

Kodi ndimwe mankhwalawa kuti ndikhale ndi prediabetes?

Inde, metformin imakuthandizani ngati mukunenepa kwambiri, makamaka mafuta osunga pamimba komanso m'chiuno. Kuchiza ndi mankhwalawa kumachepetsa mwayi woti prediabetes isanduke mtundu 2 shuga.

Muyenera kutenga metformin kuti muchepetse thupi malinga ndi malingaliro omwe afotokozedwa patsamba lino, ndikuwonjezereka pang'onopang'ono kwa mlingo watsiku ndi tsiku. Werengani mosamala ndikuonetsetsa kuti mulibe zotsutsana ndi kugwiritsa ntchito chida ichi. Ndikofunika kubwerezanso kuti mafuta a hepatosis sikuti akuphwanya.

Kodi mungachepetse makilogalamu angati kuchokera ku metformin?

Mutha kuyembekezera kuti muchepetse 2-4 kg ngati simusintha kadyedwe kanu komanso kuchuluka kwa zolimbitsa thupi. Zitha kukhala mwayi kuti muchepetse kulemera kochulukirapo, koma palibe malonjezo.

Tikubwerezanso kuti metformin ndi mankhwala okhawo omwe amathandizira kuchepetsa thupi popanda kuvulaza thanzi. Ngati pakadatha masabata asanu ndi limodzi atatha kumwa, sizotheka kuthana ndi mapaundi owonjezera owerengeka - ambiri, munthu amakhala ndi kuchepa kwa mahomoni a chithokomiro. Yesani kuyezetsa magazi kwa mahomoni onsewa, osaperekedwa ndi TSH. Chofunikira kwambiri ndi T3 yaulere. Kenako funsani ndi endocrinologist.

Mwa anthu omwe amasinthira, zotsatira za kuchepa thupi zimakhala bwino. Ambiri mwa malingaliro awo amalemba kuti adatha kutaya 15 kg kapena kupitirira. Muyenera kumwa metformin mosalekeza kuti muzisunga zotsatira zomwe mwakwaniritsa. Mukasiya kumwa mapiritsi awa, ndiye kuti gawo lina la mapaundi owonjezera ayenera kubwerera.

Elena Malysheva adapangitsa kuti metformin ikhale yotchuka ngati machiritso aukalamba, koma samalimbikitsa monga njira yothandizira kunenepa kwambiri. Amalimbikitsa makamaka kudya kwake kuti achepetse thupi, osati mapiritsi ena ake. Komabe, chakudyachi chili ndi zakudya zambiri zomwe zimadzaza ndi chakudya chamafuta.Amachulukitsa kuchuluka kwa insulin m'magazi motero amalepheretsa kuchepa kwamafuta mthupi.

Zambiri pazamankhwala odwala matenda a shuga komanso kuwonda, zomwe zimagawidwa ndi Elena Malysheva, chifukwa gawo lalikulu silolondola, ndi lakale.

Momwe mungasinthire metformin ngati sichithandiza matenda ashuga kapena amayambitsa kutsegula m'mimba?

Metformin siivuta kusinthana ndi china chake, ndimankhwala ambiri mwanjira zosiyanasiyana. Popewa kutsekula m'mimba, muyenera kumwa mapiritsi ndi chakudya, kuyamba ndi mlingo wotsika tsiku ndi tsiku ndikuwonjezera pang'onopang'ono. Mutha kuyesanso kwakanthawi kusintha kuchokera pamapiritsi a nthawi zonse kupita ku mankhwala omwe akhala akuchita kwa nthawi yayitali. Ngati metformin sichepetsa shuga m'magazi konse - ndikotheka kuti wodwalayo ali ndi matenda a shuga a 2 apamwamba kwambiri, omwe adasanduka mtundu 1 wa shuga. Pankhaniyi, muyenera kuyambitsa jakisoni mwachangu, palibe mapiritsi omwe angakuthandizeni.

Mu odwala matenda ashuga, metformin amachepetsa shuga, koma sikokwanira. Pankhaniyi, iyenera kuphatikizidwa ndi jakisoni wa insulin.

Kumbukirani kuti anthu owonda nthawi zambiri samatha kumwa mapiritsi a shuga. Afunika kusinthira ku insulin nthawi yomweyo. Kukhazikitsidwa kwa mankhwala a insulin ndi vuto lalikulu, muyenera kumvetsetsa. Nkhani zophunzira za insulin patsamba lino, funsani ndi dokotala. Choyamba, pitani. Popanda icho, kudziletsa pazabwino ndikosatheka.

Nkhani ya matenda ashuga a 2 yandisangalatsa kwa nthawi yayitali. Zinachitika kuti wachibale wapamtima anamwalira ndi matenda ashuga atapanikizika.

Kenako agogo anga anayamba kudwala matenda ashuga ali ndi zaka 80, ndipo amayi anga ali ndi zaka 52 atayamba kusamba. Izi sizinandilambire inenso, ngakhale sindinakonde maswiti, sindinamwe konse zakumwa zoledzeretsa komanso, sindinasute. Chifukwa chake sindikufuna kukhulupirira kuti moyo wanga wodwala matenda oyambawa uyamba.

Zachidziwikire, chinthu choyambirira chomwe ndidachita ndidatsitsimutsa chidziwitso changa cha zitsamba kuti ndichepetse shuga. Anayamba kulowerera mozama momwe amagwiritsidwira ntchito mankhwala a matenda ashuga, kuti adziwane ndi maphunziro atsopano okhudza iwo. Kenako ndidaphunzira zambiri za metformin - wotchuka, wodziwika wotsika shuga m'mapiritsi. Ndiyenera kunena kuti kutchuka kwake kukukula tsiku lililonse.

Metformin idapezeka mu 1922, ndipo idangogwiritsidwa ntchito kumapeto kwa 90s. Endocrinologists amati mankhwala a matenda a matenda ashuga a 2. Zoikidwazo zimadziwikanso chifukwa cha kunenepa kwambiri, kunenepa kwambiri, komwe kumayambitsa ovary komanso kubereka.

World Health Organisation yazindikira metformin ngati imodzi mwa mankhwala othandiza kwambiri.

Ndipo ngakhale kutchuka kwake kuli kokulirapo, zotsatira za metformin sizinaphunzire konse: kafukufuku akuchitika lero yemwe akuwonetsa mbali zatsopano za "talente" yake. Ndinkafuna kutchera khutu pang'ono lero.