Atorvastatin C3

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Vuto la cholesterol yayikulu m'magazi masiku ano limayang'anizana ndi ambiri. Othandizira ndi akatswiri a mtima amawunika chizindikirocho mosamala, chifukwa chimalankhula za momwe mabotiwo aliri, mphamvu zawo, komanso kuthekera kwawo kwanuko.

Sinthani magawo a cholesterol ndi mankhwala. Nthawi zambiri, Atorvastatin ndi wabwino pamenepa. Muyenera kumwa pokhapokha mukaonana ndi dokotala ndikupimidwa koyenera, komwe kumatsimikizira kupezeka kwa zisonyezo ndikukulolani kuti musankhe payekha mlingo.

Mankhwalawa ndi a gulu la pharmacological lama statins, omwe amathandizira kuyimitsa kukhathamiritsa kwa cholesterol chikhoma pamitsempha yamagazi. Nthawi yomweyo, madera omwe akhudzidwa ndi ziwiya pambuyo pa chithandizo amakhalabe yemweyo. Zinthu zomwe zili m'mankhwala zimatha kuchepetsa kuchepa kwa matenda a mtima, kuchepa kwa miyendo ndi matenda amisempha.

Atorvastatin imagwira bwino ntchito, koma chakudya chitha kukhudza pang'ono chisonyezo ichi, ngakhale kuchepa kwa ndende ya LDL m'magazi sikusintha.

Kodi gawo lina la mankhwalawa ndi chiani? Kashiamu trihydrate ndi gawo limodzi la mankhwalawa, ndipo zinthu zina zimaphatikizira:

1. cellulose
2. calcium carbonate
3. silika
4. titaniyamu
5. macrogol.

Mankhwala angagulidwe mu mlingo wa mamilimita 10, 20, 40 ndi 80.

Kuti muwone mphamvu yogwiritsira ntchito, muyenera kumwa mapiritsi pafupipafupi kwa milungu iwiri osadutsa. Pakatha mwezi umodzi, kuchuluka kwakukulu komwe kumachitika polandila kumachitika, komwe kumasungidwa chimodzimodzi.

Malangizo ogwiritsira ntchito mankhwalawa

Njira yothandizira matenda a atherosulinosis ndi cholesterol yayikulu ya magazi iyenera kukhala yokwanira. Chifukwa chake, atorvastatin tikulimbikitsidwa kuti amatengedwa nthawi yomweyo ndi chikondwerero cha chakudya cha anticholesterol, chomwe chimayenera kupitilira nthawi yonse ya mankhwala.

Mutha kumwa mankhwala osanenapo zakudyera, ndiye kuti, nthawi iliyonse yabwino kwa munthu. Mlingo wake umaperekedwa ndi dokotala aliyense payekha malinga ndi momwe akuwonera. Nthawi yonseyi, kuchuluka kwa mafuta a m'magazi amayenera kuyang'aniridwa, ndipo potengera izi, ngati kuli koyenera, sinthani mlingo ndi nthawi yayitali ya mankhwala atatha masabata awiri kapena anayi.

Mankhwalawa amayamba ndi ma milligram 10 a chinthu, ayenera kumwedwa kamodzi patsiku. Kenako kuchuluka kwa mankhwalawa kumatha kusiyanitsa pakati pa 10-80 milligrams patsiku. Ngati mankhwalawo adapangidwa kuti aphatikizidwe ndi Cyclosporine, ndiye kuti kuchuluka kwa Atorvastatin sikungakhale oposa mamiligalamu 10.

Ngati kumwa mankhwala kumalumikizidwa ndi chitukuko cha banja kapena homozygous hypercholesterolemia, ndiye kuti kudya kuyenera kukhala pafupifupi 80 mg patsiku. Kuchuluka kwake kuyenera kugawidwa m'magulu anayi a milligram 20 pachilichonse. Odwala omwe ali ndi vuto la impso safunika kusintha mlingo wa mankhwalawa, mosiyana ndi odwala omwe ali ndi vuto la chiwindi.

Ngati mankhwala osokoneza bongo akuchulukirachulukira kapena ngati mankhwalawo amachitika, muyenera kupita kwa dokotala kuti akuuzeni ngati akupereka chithandizo.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Mukamapereka mankhwala, kupezeka kwa zotsutsana pa kugwiritsa ntchito mankhwalawa kuyenera kukumbukiridwa.

Kudzilamulira nokha ndi mankhwala koletsedwa.

Nthawi yoika dokotala iyenera kuthandizidwa ndi adokotala, poganizira zomwe zingachitike mthupi la wodwalayo.

Chifukwa chiyani Atorvastatin nthawi zambiri imayikidwa?

Mankhwala awa akuwonetsedwa:

• Ndi cholesterol yayikulu.
• Ndi matenda amitsempha yamagazi ndi mtima (ngakhale matenda ngati awa sanapezeke, koma pali zinthu zomwe zingachitike ngati kunenepa kwambiri, matenda ashuga, ukalamba, matenda oopsa, komanso cholowa chotengera).
• Wodwalayo atadwala mikwingwirima, mtima, komanso apeza angina pectoris.

Monga tafotokozera kale, chithandizo ndi Atorvastatin ziyenera kuphatikizidwa ndi zakudya.

Monga mankhwala ena, mankhwalawa ali ndi zotsutsana zina kuti agwiritse ntchito.

Zotsutsana ndi izi:

1. kulephera kwa aimpso
2. matenda a chiwindi
3. mimba ndi kuyamwa,
4. zaka khumi ndi zisanu ndi zitatu,
5. tsankho pazigawo za mankhwala, momwe matendawo angayambire.

Atorvastatin sayenera kumwedwa ndi ana, komanso achinyamata omwe ali ndi zaka zosakwana ambiri, chifukwa chakuti chitetezo chogwiritsa ntchito komanso kugwiritsidwa ntchito moyenera kwa mankhwalawa kwa ana sikunakhazikike modalirika.

Sizikudziwikanso ngati mankhwalawa atha kuchotsedwa mkaka wa m'mawere. Komabe, poganizira za zovuta zomwe zimachitika mwa ana, pamene zikuwonetsa kugwiritsa ntchito mankhwalawa kwa amayi pakudya, ndikofunikira kusiya kuyamwitsa.

Koma kwa amayi omwe amamwa mankhwala akatha msambo, ayenera kugwiritsa ntchito njira za kulera panthawi yobereka.

Mwambiri, kuikidwa kwa Atorvastatin pazaka izi kumakhala koyenera ngati pali mwayi wotsika kwambiri wokhala ndi pakati, ndipo mkazi akazindikira kuopsa kwa chithandizo cha mwana wosabadwayo.

Zotsatira zoyipa za kugwiritsa ntchito mankhwalawa

Monga mankhwala ena ambiri, atorvastatin ali ndi zotsatira zoyipa zingapo zomwe zimawoneka ngati zimagwiritsidwa ntchito pochiza.

Kupezeka kwa zotsatira zoyipa kuyenera kuganiziridwa mukamamwa mankhwalawo.

Pofuna kupewa zovuta zoyipa mthupi, mankhwalawa amayenera kutumizidwa ndi adokotala okha.

Kugwiritsa ntchito mankhwala Atorvastatin kungayambitse mavuto:

• kutentha kwamphesa, nseru, kutuphuka ndi chisokonezo,
• thupi lawo siligwirizana
• thrombocytopenia, kuchepa magazi,
• rhinitis ndi bronchitis,
• matenda a urogenital, komanso kutupa,
• thukuta kwambiri
• dazi
• maonekedwe a chidwi chokulirapo,
• Maso owuma, zotupa za m'mimba,
• tinnitus, mutu ndi chizungulire,
• kusowa tulo
• seborrhea, chikanga,
• kutuluka thukuta kwambiri
• kuyabwa ndi pakhungu pakhungu,
• Amachepetsa azimayi, azimayi amadzaza komanso kusabereka,
• myalgia, nyamakazi, kukokana kwamisempha.

Kuchita ndi mankhwala ena

Sizikulimbikitsidwa kugwiritsa ntchito mankhwalawa nthawi imodzi ndi:

1. Mankhwala a antifungal.
2. Ma antibacterial othandizira, maantibayotiki.
3. Cyclosporine.
4. Amachokera ku fibroic acid.

Ndi kuphatikiza kwa mankhwalawa, kuwonjezeka kwa ndende ya Atorvastatin ndi chiwopsezo chowonjezereka cha myalgia kumayambitsa mkwiyo.

Kugwiritsa ntchito kuyimitsidwa, komwe kumakhala ndi aluminium ndi magnesium, kungathandize kuchepetsa kuchuluka kwa mankhwalawa. Koma sizikhudza kuchuluka kwa kuchepa kwa cholesterol yathunthu ndi LDL.

Mosamala kwambiri, munthu ayenera kuthana ndi kuphatikiza kwa Atorvastatin ndi mankhwala omwe amachepetsa kuchuluka kwa mahomoni a steroid (mwachitsanzo, Ketoconazole kapena Spironolactone).

Malangizo owonjezera ogwiritsira ntchito

Musanatenge Atorvastatin, tikulimbikitsidwa kuti muzikwaniritsa mafuta a cholesterol osinthika mwa kusintha moyo wanu ndikuwongolera zakudya zanu. Izi ndi njira zachilendo zopewera ndi kuchiza mitsempha yamagazi ndi matenda ena a ziwalo.

Mukamamwa mankhwalawa, myopathies amatha kuoneka - kufooka ndi kupweteka m'misempha ya thupi. Pakukayikira matenda, kugwiritsa ntchito mankhwalawa kuyenera kuyimitsidwa nthawi yomweyo. Kuphatikiza apo, chiopsezo chokhala ndi njirayi chimatha kuwonjezeka ndikugwiritsira ntchito pamodzi kwa Atorvastatin ndi Erythromycin, Cyclosporine, antifungal agents ndi nicotinic acid.

Mukamamwa mankhwalawa, muyenera kusamala mukamagwira ntchito zomwe zimafunikira chidwi chachikulu, komanso poyendetsa magalimoto.

Sitikulimbikitsidwanso kumwa ma statins ndi zakumwa zoledzeretsa, chifukwa izi zimatha kusintha zotsatira za mankhwalawo kapena kuyambitsa zotsatira zoyipa.

Mndandanda wa chida chachipatala

Mankhwala omwe ali ndi zinthu zofananira zogwira ntchito komanso zomwe zimakhudza thupi, ndipo amatha kuikidwa m'malo mwa Atorvastatin (analogues), kuphatikizapo Atoris, Tulip, Lipoford, Ator, Torvakard, Lipramar, Rosulip ndi Liptonorm.

Zimasiyana bwanji? Ngati mungafananize, mutha kuwona kuti kwenikweni kusiyanako kumangokhala kokha ndi dziko lopanga mankhwala ndi omwe amapanga. Mankhwala onse okhala ndi zinthu zofanana (zomwe zimatchedwa magenic) ali ndi mayina osiyanasiyana, zomwe zimapangitsa kuti azidzipatsa. Popeza palibe kusiyana kwazomwe zimagwirira ntchito, mankhwalawa atha kuwerengedwa ofanana ndi Atorvastatin.

Panthawi yamankhwala, Atorvastatin iyenera kusungidwa kumalo komwe kuli kutali kuti ana azitha kufikira, komwe dzuwa silikugwa. Ndikofunikira kuti kutentha kusakhale kuposa 25 digiri Celsius.

Mtengo wa mankhwalawa umapangidwa ndi kampani iliyonse yamankhwala payekhapayekha. Mtengo wapakati wamankhwala omwe amapezeka m'mapiritsi 30 ndi:

• mapiritsi okhala ndi mulingo wa 10 mg - ma ruble 140-250,
• mapiritsi okhala ndi mulingo wa 20 mg - ma ruble 220-390,
• mapiritsi okhala ndi mulingo wa 40 mg - 170-610 rubles.

Mtengo wa mankhwalawo umatengera gawo lomwe likugulitsidwa.

Malinga ndi odwala omwe agwiritsa ntchito mankhwalawa, ili ndi zotsatira zabwino komanso imathandizira kukhazikika kwa cholesterol m'thupi.

Atorvastatin akufotokozedwa mu kanema munkhaniyi.

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

The achire zotsatira za mankhwala

Mapiritsi a Atorvastatin S3 amathandizira kuchepetsa cholesterol yamagazi. Mukamagwiritsa ntchito mankhwalawa, mwayi wodwala wokhala ndi zotsatirazi zamtima zimachepa:

Mankhwala amachepetsa chiopsezo cha atherosulinosis pamaso pa zinthu zotsatirazi:

• ukalamba
• kupezeka kwa kusuta kwa chikumbumtima,
• matenda oopsa
• shuga wamagazi ambiri.

Mankhwala Atorvastatin SZ amathandiza kuchepetsa magazi. Imakonza mkhalidwe wa hematopoietic dongosolo, imalepheretsa kupasuka kwa zolembera za atherosrance.

Kuphatikiza kwa Mankhwala Osokoneza bongo

Mlingo wovomerezeka wa tsiku lililonse wa mankhwalawa umasiyana 10 mpaka 80 mg. Mankhwala ayenera kuledzera kamodzi patsiku.

Pa hypercholesterolemia yoyamba komanso kuphatikiza kwa Hyperlipidemia, mlingo woyenera watsiku ndi tsiku ndi 10 mg. Ngati wodwala ali ndi homozygous achiberekera hypercholesterolemia, woyamba mankhwalawa amasankhidwa payekhapayekha: kutengera kuwopsa kwa zizindikiro zazikulu za matendawa.

Ngati chiwindi chayamba kugwira ntchito, muyenera kusamala mukamagwiritsa ntchito mankhwalawa chifukwa kuchepa kwake kumachotsedwa m'thupi. Pamaso pa matenda amodzimodzi, ndikofunikira kuyendetsa ntchito ya hepatic transaminases:

Ndi kuchuluka kwa hepatic transaminases, kuchepa kwa mankhwala okwanira tsiku lililonse ndizofunikira.

Ngati wodwala ali ndi matenda a impso, kusintha kwa mlingo sikofunikira. Odwala okalamba ayenera kumwa mankhwalawa malinga ndi chiwembu chokhacho (popanda kukonza mlingo woyenera watsiku ndi tsiku).

Contraindication

Malinga ndi malangizo ogwiritsira ntchito, ndikofunika kusiya kugwiritsa ntchito mankhwalawa panthawi yomwe akuyembekezera mwana ndi kuyamwitsa. Mankhwalawa sayenera kuledzera pakukonzekera kutenga pakati. Amapatsirana odwala osakwana zaka 18. Mankhwalawa sayenera kumwa ndi hypersensitivity pamagawo ake. Mankhwala ndi contraindicated ngati lactose tsankho, shuga-galactose malabsorption.

Mankhwala amagwiritsidwa ntchito mosamala pamaso pa zotsatirazi:

• ochepa matenda oopsa
• khunyu
• matenda ashuga
• Matenda a minofu
• kuphwanya mulingo wamadzi-electrolyte.

Zotsatira zoyipa

Mukamagwiritsa ntchito mankhwalawa, mavuto omwe amabwera chifukwa cha mantha amawonongeka.

• mutu
• chizungulire
• kugona kuwonongeka
• kupezeka kwa asthenic syndrome,
• paresthesia
• zotumphukira neuropathy.

Mukamagwiritsa ntchito mankhwalawa, zotsatirapo zoyipa zimawonedwa:

• tinnitus
• kukomoka mtima,
• kuthamanga kwa magazi
• arrhasmia,
• mphuno
• thrombocytopenia
• nseru
• chisangalalo
• kupweteka pamimba,
• kuwonongeka kwa kaonedwe ka kukoma,
• kuchepera kuyendetsa galimoto,
• maonekedwe a kutupika m'malumikizidwe,
• minofu kukokana
• kulephera kwa chiwindi
• kutaya tsitsi
• Khungu
• zotumphukira edema,
• kupweteka pachifuwa
• ulesi
• chophimba pamaso
• kusokonezeka kwa kukumbukira
• kuchuluka kwa glycosylated hemoglobin.

Zomwe zimachitika mogwirizana ndi mankhwala ena

Atorvastatin SZ sikulimbikitsidwa kuti igwiritsidwe ntchito nthawi imodzi ndi Varvarin. Mankhwala opangidwa kuti achepetse cholesterol m'thupi samagwirizana bwino ndi othandizira awa:

• mankhwala opha ndi antifungal zotsatira,
• macrolide maantibayotiki,
• amatanthauza ndi immunosuppressive zotsatira.

Mukamagwiritsa ntchito ma antacid omwe amapanga kuti hydrochloric acid asinthe, zinthu za m'magazi zomwe zimagwiritsidwa ntchito ndi mankhwala zimatha kuchepa. Ngati pakufunika kugwiritsa ntchito mankhwalawa nthawi imodzi ndi Atorvastatin SZ, lingaliro la kuwonjezera kuchuluka kwa mankhwala ochepetsa lipid liyenera kutengedwa ndi dokotala.

Alumali moyo wa mankhwala ndi zaka zitatu. Mankhwalawa amayenera kusungidwa m'malo otetezedwa ndi dzuwa. Kutentha kwenikweni kosungirako mankhwalawo ndi madigiri 25.

Popeza mankhwalawa ali ndi tanthauzo la hypolipidemic, ndemanga zake zimagwiritsidwa ntchito nthawi zambiri. Mankhwalawa nthawi zambiri amatengedwa ndi kuwonjezeka kwa cholesterol yamagazi, limodzi ndi angina pectoris.

Nthawi yomweyo, mndandanda wazotsatira zomwe zimawonedwa mukamagwiritsa ntchito Atorvastatin SZ ndizokwera kwambiri. Izi ndichifukwa cha kuwunika koyipa kwa odwala.

Momwe mungapangitsire mphamvu ya mankhwalawo?

Kupititsa patsogolo njira yothandizirana ndi mankhwalawa, ndikofunikira kuti azitsatira zakudya zokhwima. Cholinga chake chachikulu ndikupanga metabolidi ya lipid.

Ndi kuchuluka kwa cholesterol mthupi, muyenera kuchepetsa zakudya zomwe zimakhala ndi mafuta a nyama. Chakudyacho chimaphatikizapo mbale zomwe zimakhutitsa thupi ndi fiber.

Ngati muli ndi cholesterol yambiri, muyenera kudya zakudya zomwe zimakhala ndi phytosterols yambiri. Izi zikuphatikiza:

• nthangala za sesame,
• zinthu zokhala ndi nyongolosi ya tirigu,
• mpendadzuwa
• malawi
• mafuta a azitona
• mapeyala
• mafuta a mphesa.

Chakudyacho chilinso ndi zakudya zopatsidwa ndi pectin: zipatso za malalanje, maapulo, mavwende. Ndi cholesterol yayikulu magazi, zotsatirazi ndizothandiza:

• sipinachi
• masamba obiriwira letesi
• artichoke
• sorelo
• katsabola
• parsley.

Mukamagwiritsa ntchito mankhwala a Atorvastatin SZ, tikulimbikitsidwa kuti musiye kugwiritsa ntchito nkhumba, nyama ya bakha, offal, nyama zosuta, masoseji. Mitundu yamafuta am'madzi, nsomba yofiira caviar, shrimp, ndi nsomba zam'chitini zimagwiranso oletsedwa.

Ndikulimbikitsidwa kupatula muzakudya zomwe zidatchulidwa mndandanda:

• Kuphika batala
• msuzi wa bowa
• zonona
• tchizi chamafuta ambiri,
• wowawasa zonona
• ayisikilimu
• mankhwala achokoleti
• mafuta a kanjedza,
• mayonesi
• ketchup.

Atorvastatin ali ndi ma analogu. Tulip amagwiritsidwa ntchito pa matenda ophatikiza hyperlipidemia, hypercholesterolemia yoyamba.

Ndi bwino kusiya kugwiritsa ntchito mankhwalawa ndi hypersensitivity ku zigawo zake, lactose tsankho. Tulip ndi oletsedwa kugwiritsa ntchito nthawi yapakati komanso yoyamwitsa. Mankhwalawa saloledwa kuperekedwa kwa odwala osakwana zaka 18.

Tulip iyenera kugwiritsidwa ntchito mosamala ndi kuthamanga kwa magazi, sepsis, kukondera kwa elekitirodi.

Mukamamwa mankhwalawa, zotsatirapo zoyipazi zingachitike:

• asthenia
• mutu
• kufooka koopsa
• kuoneka kwa zowawa m'malungo,
• edema
• mawonekedwe a totupa pakhungu,
• tinnitus
• maonekedwe onenepa kwambiri
• utachepa potency
• kumachitika zakumwa.
• zotumphukira neuropathy,
• thrombocytopenia.

Mlingo wa tsiku ndi tsiku wa Tulip umasiyana 10 mpaka 80 mg. Nthawi zambiri, wodwala mankhwala 10 mg mg wa mankhwala patsiku.

Lipitor ilinso ya gulu la ma statins. Mankhwalawa amathandizira kuchepetsa cholesterol mwa odwala omwe apezeka ndi homozygous Famel hypercholesterolemia.

Zizindikiro zotsatirazi zakugwiritsa ntchito Lipitor ndizodziwika:

• mimba
• nthawi yoyamwitsa,
• Hypersensitivity pamagawo a mankhwala,
• kukhalapo kwa kwambiri chiwindi matenda.

Lipitor imagwiritsidwa ntchito mosamala pamaso pa kudalira zakumwa zoledzeretsa, kuthamanga kwa magazi, komanso kukondera kwa electrolyte. Mukamagwiritsa ntchito mankhwalawa, mavuto monga mseru, kusokonezeka m'mimba, mawonekedwe a pakamwa owuma, mutu, kugona, chizungulire, arrhasmia, ndi kuthamanga kwa magazi zimawonedwa. Nthawi zina, pogwiritsa ntchito Lipitor, zovuta zotere zimabuka:

• Maonekedwe a matumbo a m'miyendo,
• kupezeka kwa magazi mu ukazi mwa azimayi,
• zokonda mtima
• youma conjunctiva
• thukuta kwambiri
• kupezeka kwa zizindikiro za bronchitis kapena rhinitis.

Pomaliza, ziyenera kudziwidwa kuti mankhwalawa amagwiritsidwa ntchito mwachangu osati kungodziletsa. Mankhwalawa amachepetsa mwayi wa atherosulinosis pamaso pa chibadwa cha matenda.

Zotsatira za pharmacological

Mankhwalawa ali ndi vuto linalake la kuphatikizika kwa ma steroid ndi cholesterol. Chosakaniza chophatikizacho chili ndi chiyambi chopangidwa. Ndi choletsa mpikisano wa enzyme HMG-CoA reductase, yomwe imagwira ntchito kwambiri pakupanga kwa mevalonate - chinthu chofunikira pakapangidwe kolesterol.

Chida chimakupatsani mwayi wotsitsa cholesterol, LDL, triglycerides mwa anthu omwe ali ndi homo- kapena heterozygous achibale hypercholesterolemia. Zimakupatsanso mwayi wowonjezera kuchuluka kwa milomo ya lipoprotein, yomwe imakhala yopindulitsa thupi.

Chidacho chimakuthandizani kuti muchepetse cholesterol, LDL, triglycerides mwa anthu omwe ali ndi vuto la heterozygous Famer hypercholesterolemia.

Atorvastatin samangolepheretsa zochitika za enzyme zomwe zimakhudzana ndi kaphatikizidwe ka cholesterol, komanso zimathandizira kuthetsa izi. Izi zimatheka pochulukitsa kuchuluka kwa ma cell receptor omwe amamangilira ochepa osalimba lipoprotein ndikupatsanso kuwonongeka kwina kwa mankhwala.

Atorvastatin imabweretsa kusintha kwa chiŵerengero cha ma lipoprotein apamwamba komanso otsika kwambiri poletsa kupanga kwaotsirizira, kugwiritsa ntchito kwawo, komanso kusintha kosangalatsa mu tinthu tomwe. Chipangizocho chikugwira ntchito bwino mukamamwa mankhwala ena otsika a lipid, mulingo wa LDL sukuchepa.

Mothandizidwa ndi atorvastatin, kuchuluka kwa cholesterol m'magazi kumatsika mpaka 50%, LDL mpaka 60%, apolipoprotein-B mpaka 50%, triglycerides mpaka 30%. Zambiri zomwe zimapezeka poyesa mankhwalawa zinali zofanana kwambiri mwa anthu omwe ali ndi vuto la chibadwa komanso losakhala la hypercholesterolemia, hyperlipidemia komanso matenda osokoneza bongo omwe amadalira insulin.

Mothandizidwa ndi atorvastatin, mphamvu yamagazi yopanga magazi imatheka chifukwa chochepetsa kukhuthala kwake. Kutsika kwa zochitika za zomatira zamapulatifomu ndi zina za njira zophatikizika zimawonedwa. Mankhwala amakhudza zochitika za macrophages, kupewa kupindika kwa zolembedwa za atherosrance, zomwe zitha kuchitika ndi kutenga nawo mbali.

Mothandizidwa ndi atorvastatin, mphamvu yamagazi yopanga magazi imatheka chifukwa chochepetsa kukhuthala kwake.

Chidachi chitha kuchepetsa ngozi yaimfa chifukwa cha minyewa ya ischemia ndi 15% mukamamwa mlingo wa 80 mg. Kuchuluka kwa kuchepa kwa zomwe zili za lowopsotein m'magazi kumatengera Mlingo womwe umamwa.

Pharmacokinetics

The yogwira pophika mankhwala akumwa pakamwa ndi mwachangu odzipereka ndi mucous nembanemba zam'mimba thirakiti. The pazipita ogwira ndende ya yogwira plasma anati 60-120 mphindi pambuyo makonzedwe. Kwa odwala achikazi, zomwe zili mu atorvastatin m'magazi ndi 1/5 kuposa amuna. Mlingo wapamwamba wa mankhwalawa umatengedwa mwachangu kwambiri, ndende ya plasma imatengera kuchuluka kwa mankhwala omwe amwedwa.

Chiwerengero chonse cha bioavailability cha gawo yogwira ndi 15%. Pafupifupi 30% ya mlingo wotengedwa mopikisana umalepheretsanso kuchepa kwa HMG-CoA. Mlingo wa bioavailability wa atorvastatin ndi chifukwa cha kusintha kwa kagayidwe kachakudya komwe kamatulukiridwa m'matumbo a mucosa ndi hepatobiliary. Mukamadya chakudya, kuthamanga komanso kulemera kwa zinthu zogwira ntchito kumachepetsedwa.

Ikalowa m'magazi am'magazi, mankhwalawo amakhala pafupifupi kuti azinyamula ma peptides. Chithandizo chogwira ntchito m'miyeso yaying'ono imalowa mkati mwa maselo ofiira a m'magazi.

Mlingo wa bioavailability wa mankhwalawa ndi chifukwa cha kusinthika kwa metabolic komwe kumawululidwa m'matumbo mucosa.

Panthawi ya metabolic kutembenuka kwa atorvastatin, zinthu ziwiri zimapangidwa. Zochita za metabolites zikufanana ndi zomwe zidayamba. Mpaka 70% ya machitidwe a mankhwalawa amaperekedwa chifukwa cha zochita za metabolites.

Kutembenuka kwa mankhwala a atorvastatin mu thirakiti la hepatobiliary kumachitika mothandizidwa ndi CYP3A4 isoenzyme. Yogwira pophika mankhwala mpaka kumalepheretsa ntchito yake.

Kuchoka kwa mankhwalawa kumachitika makamaka ndi kutuluka kwa ndulu. Hafu ya moyo ndiyopitilira maola 12. The achire zotsatira za atorvastatin kumatha pafupifupi tsiku.

Zizindikiro zogwiritsidwa ntchito

Zizindikiro zakugwiritsa ntchito chida ichi ndi:

• hypercholesterolemia yam'banja komanso yopanda mabanja,
• kuphatikiza matenda ophatikizira,
• Matenda ogwirizana ndi vuto la betalipoproteins,
• cholowa cholowa m'magazi.

Atorvastatin amagwiritsidwanso ntchito ngati mankhwala popewa matenda a mtima. Imagwiritsidwanso ntchito kupewa zina zachiwiri kwa odwala omwe ali ndi matenda a mtima. Zimathandizira kuchepetsa chiwopsezo cha kufa kwa omwe ali mgululi.

Ndi chisamaliro

Chenjezo makamaka pakumwa mankhwala liyenera kuchitika kwa odwala omwe ali ndi vuto la chiwindi. Kuphwanya wachibale ndiko uchidakwa, popeza uchidakwa ungakhale chifukwa chakuwonekera kwa matenda a hepatobiliary thirakiti.

Atorvastatin simalimbikitsidwa kwa anthu omwe ali ndi mavuto awa:

• zosokoneza pamiyeso yamagetsi,
• hyperthyroidism
• kagayidwe kachakudya matenda
• septicemia
• kuthamanga kwa magazi
• SD
• khunyu
• opaleshoni yaposachedwa.

Momwe mungatenge atorvastatin C3

Mankhwala amatengedwa pakamwa, mosasamala nthawi ya tsiku. Mankhwala a Atorvastatin amachitika pambuyo poyesayesa kuti azilamulira kuchuluka kwa cholesterol pogwiritsa ntchito zakudya zapadera. Ngati sichitha, kuwonjezera pazoletsa chakudya, wodwala ayenera kumwa mankhwalawa.

Mapiritsi a Atorvastatin C3 amatengedwa kamodzi patsiku.

Mukamasankha mlingo wa tsiku ndi tsiku wa munthu, kuuma kwa matendawa amakumbukiridwa. Monga momwe mungathere, 80 mg ya mankhwala patsiku amatha kufotokozera. Mapiritsi amatengedwa kamodzi patsiku.

Kusankhidwa kwa Mlingo wofunikira nthawi zambiri kumayamba ndi kuperekedwa kwa pafupifupi 10 mg. Kenako, theka lililonse la mwezi kapena mwezi, wodwalayo amayenera kuwunika zomwe zili zam'magazi m'magazi. Kutengera luso la mankhwalawa, mlingo wake umakulira kapena kukhalabe wofanana.

Matumbo

Atha kuyankha pa chithandizo chotsatira:

• kugaya chakudya
• ukufalikira
• kupweteka kwa epigastric
• kuchuluka kwa chiwindi michere,
• jaundice
• kutupa kwa kapamba,
• nseru
• kusanza

Kutenga Atorvastatin C3 kungayambitse kutulutsa.

Kuchokera ku minculoskeletal system

• kupweteka kwa minofu
• kupweteka kwa molumikizana
• kukokana
• zingwe za tendon.

Atorvastatin C3 imatha kupweteketsanso minofu.

• anaphylactic reaction,
• necrolysis yoopsa.

Malangizo apadera

Pa mankhwala ndi atorvastatin, zimakhudza minofu yamimba. Izi zimafunikira kuwunika kwa mtundu wa creatine phosphokinase. Ngati zizindikiro za myopathy zikuwoneka, siyani kumwa mankhwalawa. Wodwala ayenera kufunsa dokotala ngati pali kupweteka m'misempha kapena kufooka kwa minofu.

Zokhudza mphamvu pakuwongolera njira

Pakakhala zovuta m'magulu amanjenje, muyenera kuchepetsa nthawi yomwe mumagwiritsa ntchito gudumu chifukwa cha chitetezo.

Ngati zovuta zoyipa zokhudzana ndi mitsempha zimachitika, kayendedwe ka mayendedwe akuyenera kukhala ochepa.

Kugwiritsa ntchito kwa vuto la chiwindi

Chithandizo cha odwala aimpso kukanika kuyenera kuchitika pang'onopang'ono kuwunika kwa chiwindi michere. Kutengera ndi kuchuluka kwa ntchito zawo, mlingo wa mankhwalawo umawongoleredwa.

Impso sizitenga nawo mbali mu kagayidwe kapena katemera wa mankhwalawa.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito palimodzi ndi phenazone sikumayendera limodzi ndi kusintha kwa mankhwala a pharmacokinetic a othandizira onse.

Kugwiritsa ntchito pamodzi kwa maantacid kumapangitsa kuchepa kwa zomwe atorvastatin zili m'magazi. Izi zimachitika chifukwa chosayamwa bwino kwa mankhwala osakaniza.

Mankhwala omwe amalimbikitsa ntchito ya CYP3A4 isoenzyme amachepetsa kuchuluka kwa mankhwalawa m'magazi am'magazi. Rifampicin ali ndi mphamvu paimpso, motero, sizikhudza ma pharmacokinetics a mankhwalawa.

Kukhazikitsa pamodzi kwa Atorvastatin ndi Cyclosporine kungakulitse chiopsezo cha minofu pathologies.

Kugwiritsira ntchito mosiyanasiyana ndi digoxin muyezo wotsika sikumasintha mphamvu ya mankhwalawa. Pa mlingo waukulu wa atorvastatin, kuwonjezeka kwa 1/5 kwa plasma digoxin ndizotheka.

Cyclosporine ikhoza kukulitsa chiopsezo cha kupsinjika kwa minofu.

Palibe kuyanjana kofunikira kwa mankhwala ndi terfenadine komwe kunadziwika.

M'malo otsatirawa mankhwalawa:

Ndemanga ya Atorvastatin C3

Gennady Ishchenko, katswiri wa zamtima, Moscow

Atorvastatin ndi mankhwala omwe amakupatsani mwayi wowongolera kuchuluka kwa lipids m'matenda ena. Amalandira onse kwa anthu omwe ali ndi cholowa chowonjezereka mu plasma ya cholesterol ndi mafuta ena, komanso kwa odwala omwe apeza matenda amtunduwu.

Chidachi chimathandizira kupewa zovuta zamtima. Kuphatikiza pa zakudya zoyenera, odwala amatha kukhala ndi kulemera koyenera kwa thupi ndikuyamba kukhala ndi chizolowezi chodziwika bwino popanda kuda nkhawa ndi zovuta za mtima.

Larisa Oleshchuk, wothandizira, Ufa

Chida ichi chimapatsa anthu omwe ali ndi mabanja amkati mwa hypercholesterolemia mwayi wokhala ndi moyo wabwinobwino. Ndimapereka mankhwala a atorvastatin osati kwa iwo okha, komanso kwa odwala ena omwe ali ndi chiopsezo chowonjezereka cha ma atherosulinotic amana ndi ma pathologies awo.

Sindikupangira kuti mugule mankhwalawo pawokha pa pharmacy nokha. Chithandizo chimafuna kusankha koyenera kwa Mlingo watsiku ndi tsiku komanso kuwunika kwakanthawi kwamlingo wa hepatic transaminases. Ngati sichitsatiridwa, chithandizo chamankhwala chimatha kubweretsa zovuta zoyipa.

Andrey, wazaka 48, St. Petersburg

Njira yabwino yothetsera. Kuphatikiza ndi zakudya zapadera, zimathandizira kuti mafuta a cholesterol azikhala m'malo oyenera. Ndimatenga monga adalamulira adokotala, ndimapereka mayeso onse panthawi. Pakadali pano, palibe madandaulo omwe abwera. Ngati muchita chilichonse monga momwe zalembedwera malangizo ogwiritsira ntchito, ndiye kuti palibe mavuto munthawi ya chithandizo. Osamangodzisamalira. Kuyang'anira dokotala pafupipafupi ndiye njira yofunika kwambiri yoperekera chithandizo.

Elizabeth, wazaka 55, Perm

Ndinayesa kutenga atorvastatin. Mankhwalawa adatha milungu iwiri. Kenako adayamba kuwona kufooka m'misempha, kupweteka kuwonekera. Poyamba sindinatanthauze kufunikira kwa izi, koma Zizindikiro zitayamba kufalikira, ndinapita kwa adotolo. Adachita mayeso onse ofunikira ndikuyika kuchipatala. Oletsedwa kumwa mankhwalawa.

Chifukwa chake sindinangokhala bwino, komanso pafupifupi moyo wanga wonse. Samalani ndi mankhwalawa ndikupeza katswiri yemwe azikuyang'anirani mosamala mukamaliza.

Daniel, wazaka 29, Omsk

Ndili ndi matenda obadwa nawo a hypercholesterolemia. Mlingo wa lipids m'magazi uyenera kuchepetsedwa nthawi zonse. Ndimachita izi ndi mankhwala ngati Atorvastatin. Kuyika sikokwera mtengo kwambiri poyerekeza ndi anzawo akunja, koma zotsatira zake ndi zomwezo. Nditha kulimbikitsa chida ichi kwa anthu onse omwe akumana ndi matenda ofanana. Ngati muthandizidwa malinga ndi malingaliro a dokotala, mutha kukhala moyo wonse.