Malangizo ogwiritsira ntchito "Trazhenty", kapangidwe, ma analogi, mtengo ndi ndemanga za anthu odwala matenda ashuga

Mankhwalawa amalembedwa kuti agwiritsidwe ntchito kwa akulu matenda a shuga 2.

Monotherapy ndi mankhwalawa zimasonyezedwa pokhapokha kutseguka kwa zochitika zolimbitsa thupi komanso kusunga zakudya zamagulu ochepa sikunalole kuyendetsa mndandanda wamagulu a shuga. Ndikotheka kutenga mapiritsi awa ndi tsankho la zinthu monga metformin kapena kukhalapo kwa contraindication pa zomwe mumamwa.

Chithandizo chophatikiza (ngati mankhwala othandizira pakudya ndi zolimbitsa thupi sizothandiza):

• Pamodzi ndi metformin,
• Ndi sulfonylurea komanso metformin
• Ndi insulin ndi metformin.

Kupanga ndi mafomu omasulira

Pa mapiritsi a Trazent, pali gawo lokhalo lomwe limayimiriridwa ndi linagliptin, kachigawo kake kaudzu mumankhwala ndi 5 mg. Zina zomwe zilipo:

• Wowuma chimanga
• Mannitol
• Magnesium wakuba
• Kuphimba pinki Opadry.

Mapiritsi a Terzent 5 mg a tint ofiira okhala ndi mbali zam'mphepete, mbali imodzi pali chizindikiro "D5". Mapiritsi amayikidwa mu chithuza chamtundu wa ma 7 ma PC. Mukati mwa paketiyo pali matuza 5.

Kuchiritsa katundu

The yogwira mankhwala Trazhenty ndi amodzi mwa zoletsa wa enieni enzyme dipeptidyl peptidase-4. Mothandizidwa ndi chinthu ichi, kuwonongeka kwa mahomoni a insretin amawonedwa, omwe akuphatikizanso HIP, komanso GLP-1 (amathandizira pakuwongolera kuchuluka kwa shuga).

Kuchuluka kwa mahomoni kumawonjezeka pafupifupi chakudya chikangotha. Ngati m'magazi muli mulingo wabwinobwino wama glucose kapena akuwonjezeka pang'ono, ndiye mothandizidwa ndi HIP ndi GLP-1, kuthamanga kwa kaphatikizidwe ka insulin kumawonedwa, kumakhala kobisika kwambiri ndi kapamba. Kuphatikiza apo, GLP-1 imalepheretsa njira yopanga shuga m'magazi.

Analogs a Tredent ya mankhwala ndi mankhwalawo pawokha amawonjezera kuchuluka kwa ma insretin, motsogozedwa ndi mankhwala, ntchito yawo yogwira (kuwonjezeka kwa kapangidwe ka insulin) imawonedwa.

Ndikofunika kudziwa kuti mankhwalawa amathandizira kuwonjezeka kwa shuga omwe amadalira glucose, pomwe amachepetsa secretion wa glucogan, chifukwa cha izi, kuchuluka kwa shuga m'magazi kumachitika.

Trazenta: malangizo onse ogwiritsira ntchito

Mtengo: kuchokera ku 1610 mpaka 1987 rubles.

Ndikulimbikitsidwa kugwiritsa ntchito piritsi limodzi kamodzi patsiku. Ntchito Terzety zitha kuchitika mosasamala chakudya.

Ngati piritsi la mankhwala a hypoglycemic lasowa, muyenera kumwa nthawi yomweyo, chifukwa mukukumbukira zapita. Ndikofunika kudziwa kuti kumwa kawiri pa mankhwalawa masana kumatsutsana.

Mlingo kusintha mwa anthu omwe ali ndi matenda a impso, komanso chiwindi ndi odwala okalamba, sikuchitika.

Contraindication ndi Kusamala

Hypoglycemic mankhwala sayenera kuyamba ndi:

• Mtundu woyamba wa shuga
• Zaka zaana (mwanayo ali ndi zaka 18)
• Kumvera pa chinthu chachikulu kapena zowonjezera
• Matenda a shuga ketoacidosis
• Mimba, GV.

Matenda samadziwika kwa anthu omwe ali ndi zizindikiro za ketoacidosis, komanso njira ya matenda a shuga.

Popeza kuti mankhwala ena amachokera ku sulfonylurea amachititsa kuti hypoglycemia ipite patsogolo, mankhwalawa amayikidwa mosamala kwambiri ngati ataperekedwa munthawi yomweyo. Ngati ndi kotheka, mlingo wa mankhwalawa umachepetsedwa.

Kulandila linagliptin sikukweza mwayi wakuvutika kwa CCC.

Kuphatikiza ndi mankhwala ena a hypoglycemic, amatha kuikidwa ngakhale mu kulephera kwambiri kwaimpso.

Mukamamwa mapiritsi pamimba yopanda kanthu, pamakhala kuchepa kwakukulu kwa glycosylated hemoglobin ndi glucose.

Ngati mankhwalawa atengedwa ndi odwala okalamba, kuchepa kwa hemoglobin ya glycated ndikotheka, pomwe magazi othamanga amachepa.

Hypoglycemic mankhwala sichikhudza kuwonjezeka kwa chiwopsezo cha mtima.

Nthawi zina, munthawi ya chithandizo ndi Trazhenta, kukula kwa kapamba am'mimba amatha kulembedwa. Pazizindikiro zoyambirira za matendawa, ndikofunikira kumaliza mankhwalawa a mapiritsi a hypoglycemic ndikuonana ndi dokotala.

Poyerekeza ndi chithandizo cha mankhwalawo, kupezeka kwa chizungulire sikumawonetsedwa, pazomwezi, chisamaliro chapadera chidzafunika kuthandizidwa poyendetsa magalimoto enieni, komanso magalimoto.

Kuchita mankhwala osokoneza bongo

Ndi kuphatikiza kwa ritonavir (mlingo wa 200 mg), kuwonjezeka kwa AUC ndi Cmax ya linagliptin palokha kumawonedwa mu 2 r. ndi 3 tsa. motero. Kusintha kotereku sikungatchulidwe kuti kwakukulu, motero palibe chifukwa chokwaniritsira mlingo womwe wapatsidwa.

Mukamatenga rifampicin, mfundo za AUC ndi Cmax zimatsika mpaka 40-43%, kuchepa kwa kuponderezedwa kwa ntchito zoyambira za dipeptidyl peptidase-4 yokha imawonedwa ndi pafupifupi 40%.

Mankhwala omwe munthawi yomweyo ndi digoxin alibe phindu lililonse pa pharmacokinetics yogwira ntchito.

Linagliptin imatha kukhudza kagayidwe kachakudya, koma pang'ono. Mukamamwa mankhwala osokoneza bongo, kusintha kwa kagayidwe kazomwe kamachitika ndi gawo la CYP3A4, muyenera kusintha mlingo wa Trazhenta.

Zotsatira zoyipa ndi bongo

Pa mankhwalawa a Trazhenta, kukula kwa zizindikiro zam'mbuyo kumawonedwa, izi zimachitika chifukwa cha machitidwe ena a thupi. Nthawi zina, zizindikiro zoyipa sizikhala ndi vuto lalikulu, chifukwa zimakhala zovuta.

Mawonekedwe olakwika omwe amapezeka nthawi zambiri ndi awa:

• Hypoglycemia
• Kukula kwa kapamba
• Kulemera
• Mutu komanso chizungulire chachikulu
• Kukhazikika kwa nasopharyngitis
• Zosintha ndi mtundu wa urticaria
• Kutsokomola.

Mukakumana ndi zomwe tafotokozazi, muyenera kufunsa dokotala kuti akuthandizeni. Pazochitika zoyipa, mankhwalawa amachotsedwa, kuchipatala kumafunika.

Nthawi zina, adokotala angakulangizeni m'malo mwa Trazent ndi analogues.

Milandu yamankhwala osokoneza bongo sanalembedwe.

Mukamamwa mankhwala ochulukirapo a Trazhenta, machitidwe otupa am'mimba adzafunika. Ndikofunikira kuyang'anira shuga wamagazi ndikuwachitira chithandizo chamankhwala moyang'aniridwa ndi katswiri.

MSD PHARMACEUTICALS, Netherlands

Mtengo kuyambira 1465 mpaka 1940 rubles.

Januvia - mankhwala ozikidwa ndi sitagliptin, amawonetsa kutchulidwa kwa hypoglycemic. Amalembera mankhwalawa mtundu wa matenda a shuga 2 (onse a monotherapy ndi mankhwala ophatikizidwa). Amapezeka mu piritsi.

Ubwino:

• Itha kulembedwa kwa anthu omwe ali ndi matenda a chiwindi
• Mapiritsi othandizira
• Itha kuchitika mosasamala zakudya.

Chuma:

• Mtengo wokwera
• Osapatsidwa ana osakwana zaka 18
• Sayenera kuphatikizidwa ndi cyclosporine.

Novartis Pharma, Switzerland

Mtengo kuyambira 715 mpaka 1998 rub.

Mankhwalawa amatengedwa kuti azichiza matenda a shuga (mawonetseredwe a hypoglycemic action). Gawo lalikulu la Galvus - vildagliptin limakhudza makamaka kapamba ndipo limaletsa enzyme dipeptidyl peptidase-4, chifukwa chomwe pamakhala kuchepa kwa shuga wamagazi ndikulimbikitsidwa kwa insulin. Mankhwala amapatsidwa mtundu wachiwiri wa shuga, muyeso wa mankhwalawa umakhazikitsidwa payekhapayekha. Fulu lomasulidwa la Galvus ndi magome.

Ubwino:

• Itha kugwiritsidwa ntchito ndi metformin
• Wolekeredwa bwino
• Mkulu bioavailability wa yogwira mankhwala - 85%.

Chuma:

• Otsimikizika mu kulephera kwa mtima
• Sayenera kuphatikizidwa ndi mowa
• Kuchiza ndi kothandiza pokhapokha ngati chakudya.

Pharmacodynamic ndi pharmacokinetic katundu

Linagliptin ndi choletsa wa enzyme DPP-4. Zimathandizira inactivate ma hormone ma protein - GLP-1 ndi ISU. Enzyme DPP-4 imapha mofulumira mahomoni awa. Ma insretins amakhala ndi kuchuluka kwa thupi la glucose. Miyezo ya GLP-1 ndi GUI ndiyotsika masana, koma imatha kuwonjezeka pambuyo pa chakudya. Ma insretin amenewa amalimbikitsa insulin biosynthesis ndi kapangidwe kake ka kapamba pamlingo woyenera komanso wokwera wa shuga. Kuphatikiza apo, GLP imayambitsa zinthu zomwe zimalepheretsa kupanga shuga ndi chiwindi.

Linagliptin amalowa muubwenzi womwe ungasinthe ndi DPP-4, womwe umawonjezera kuchuluka kwa ma insretin ndikuwasunga kukhala achangu kwa nthawi yayitali.

Zofunika! "Trazhenta" imayambitsa katemera wa insulini ndipo amalepheretsa kupanga shuga, komwe kumayambitsa kukhazikika kwa shuga mthupi.

Kuchokera pazomwe amachiritsa, pomwe zingavulaze

Matenda a 2 a shuga:

• komanso monotherapy kwa odwala omwe ali ndi vuto loperewera la glycemia motsutsana ndi zoletsa za zakudya ndi zolimbitsa thupi, komanso tsankho la metformin kapena kulephera kugwiritsa ntchito matenda a impso.
• monga gawo la chithandizo chovuta limodzi ndi metformin, sulfonylurea derivative (SM) kapena thiazolidinedione, ngati sichimva kupumula chifukwa chamadongosolo olimbitsa thupi komanso kuchita masewera olimbitsa thupi, kapena ngati zinthu zomwe zili pamwambapa sizikupatsani zotsatira zabwino monga monotherapy,
• ngati gawo la mankhwala othandizira atatu okhala ndi metformin ndi SM pang'onopang'ono pazakudya zopanda pake, kuchita masewera olimbitsa thupi kapena kugwiritsa ntchito limodzi mankhwalawa.

Komanso, mankhwalawa a matenda a shuga a Trazenta, wodwalayo amaloledwa kugwiritsa ntchito:

• insulin
• metformin
• pioglitazone,
• sulfonylureas.

Sizoletsedwa kugwiritsa ntchito mankhwalawa kwa anthu omwe akudwala:

• Mtundu woyamba wa shuga
• matenda ashuga ketoacidosis,
• Hypersensitivity a kapangidwe ka "Trazhenty".

Komanso, mankhwalawa sayenera kugwiritsidwa ntchito pochiza:

• ana ochepera zaka khumi ndi zisanu ndi zitatu,
• azimayi oyembekezera
• amayi oyamwitsa.

Zotsatira zoyipa zomwe zingachitike

Kukula kwa zotsatira zoyipa kumadalira kwambiri kugwiritsa ntchito Trazenti.

1. Pa mononotherapy, wodwalayo amakula: hypersensitivity, chifuwa, kapamba, nasopharyngitis.
2. Kuphatikizidwa ndi metformin kumayambitsa kupezeka kwa hypersensitivity, kutsokomola, kukodzetsa, nasopharyngitis, kutupa kwa kapamba.
3. Ngati wodwala agwiritsa ntchito mankhwala omwe ali ndi SM, ndiye, kuwonjezera pazotsatira zoyipa, chiopsezo chokhala ndi hypertriglyceridemia chikuwonjezeka.
4. Kuphatikizika kwa "Trazhenty" ndi pioglitazone kumatha kuyambitsa zotsatirazi zoyipa, hyperlipidemia ndi kuwonda.
5. Kugwiritsa ntchito limodzi nthawi imodzi ndi insulin, zomwe zafotokozedwapo zoyipa ndi kudzimbidwa zimatha kuchitika.
6. Kugwiritsa ntchito pambuyo potsatsa kungayambitse kugunda kwa angioedema, urticaria, totupa, ndi kapamba pachimake.

Mlingo wambiri, zotsatira za mankhwala osokoneza bongo

Mapiritsi amatengedwa pakamwa. Monga lamulo, mlingo wa tsiku ndi tsiku ndi 5 mg. Ngati wodwalayo angawagwiritse ntchito ndi metformin, mulingo womaliza umakhalabe womwewo.

"Trazhentu" ungagwiritsidwe ntchito mosasamala kanthu za kudya kwakudya.

Ngati wodwala matenda ashuwalayiwala kuiwala kumwa mankhwalawo, ayenera kutero nthawi yomweyo, koma osapitilira muyeso womwe walangizidwa.

Kulephera kwamakina sikutanthauza kusintha kwa Trazenti.

Anthu odwala matenda ashuga omwe ali ndi vuto la chiwopsezo cha mankhwalawa amathanso kumwa mankhwala, koma amayenera kuyang'aniridwa ndi achipatala pafupipafupi.

Kafukufuku wasonyeza kuti kupitilira muyeso wa tsiku lililonse pofika nthawi ya 120, ndiye kuti kumwa mankhwala a 600 mg sikunapweteketse anthu okhala ndi thanzi labwino.

Wodwala matenda ashuga atadwala chifukwa cha kuchuluka kwa mankhwalawa, ayenera:

• chotsani mankhwala otsalira ogaya chakudya,
• kukayezetsa kuchipatala
• gwiritsani ntchito zizindikiro.

Zofunika! Katswiri wodziwa bwino yekha ndi amene ayenera kusankha kuti wodwala atenge "Trazhenta" popanda zosokoneza.

Kuphatikiza ndi mankhwala ena

Kufanana kwa Trazhenta ndi Metformin, ngakhale pa kuchuluka kwa mafuta, sikubweretsa kusintha kwakukulu pamapangidwe a pharmacokinetic a mankhwala onse awiri.

Makonzedwe munthawi yomweyo omwe ali ndi "pioglitazone" samakhudzanso mankhwalawa a mankhwalawa onse.

"Trazhenta" ikhoza kugwiritsidwa ntchito kuphatikiza "Glibenkamid", pokhapokha pazoyambira pazotsiriza ndizochepa. Mankhwala ena omwe ali ndi sulfinyl urea nawonso amakhala ndi zofananira.

Kuphatikizidwa kwa "Trazhenty" ndi "Rifampiin" kumachepetsa kusuntha kwa oyamba. Katundu wa pharmacological amasungidwa pang'ono, koma kuwonjezeka kwa 100% sikudzakhalanso.

Mutha kumwa Digoxin nthawi yomweyo Trazenta. Kuphatikiza koteroko sikukhudza ma pharmacokinetic omwe amapezeka pamankhwala awa. Njira yofananira imachitika ndikuphatikizira kwa linagliptin ndi Warfarin.

Kusokera kwina kwalembedwa ndi kayendedwe kamodzi ka linagliptin ndi Simvastatin.

Mukamagwiritsa ntchito Transit, odwala matenda ashuga amatha kugwiritsa ntchito bwino.

Analogs ndi kufanana kwa mankhwalawo

Ngati munthu wodwala matenda ashuga sangathe kutenga Trazent pazifukwa zina, mwina akhoza kulowetsedwa.

Malangizo apadera

"Trazent" amaletsedwa kupangira T1DM ndi ketoacidosis (yotsatira T1DM).

Kafukufuku wasonyeza kuti hypoglycemia mukamagwiritsa ntchito mankhwala osakanikirana samayambitsidwa ndi Transjet, koma ndi mankhwala a metformin ndi thiazolidatedione, kapena zinthu za gulu la sulfinyl urea. Ndi kuthekera kwakukulu kwa hypoglycemia, mlingo wotsiriza umayenera kusintha.

Linagliptin sangathe kuyambitsa matenda a CCC. Kuphatikiza ndimankhwala ena, imatha kuperekedwa kwa odwala omwe ali ndi vuto laimpso.

M'madera ena odwala matenda ashuga, mankhwalawa amapangitsa kuti pakhale pancreatitis yayikulu. Pazizindikiro zake zoyambirira (kupweteka kwambiri pamimba, kusokonekera kwa matenda komanso kufooka wamba), wodwala matenda ashuga ayenera kupuma pogwiritsa ntchito Trazenti ndi kukaonana ndi dokotala nthawi yomweyo.

Pakadali pano, palibe chidziwitso cha momwe mankhwalawo amathandizira odwala matenda ashuga kuwongolera njira zosiyanasiyana. Koma chifukwa choti wodwalayo amatha kukumana ndi mavuto, kumwa mankhwalawa musanachitike zomwe zimafunikira kuchitapo kanthu mwachangu ndi kusunthika koyenera kuyenera kuchitika molondola kwambiri.

Ambiri omwe ali ndi matenda ashuga amagwiritsa ntchito mankhwalawa monga gawo la zovuta mankhwala, motero zimakhala zovuta kudziwa momwe zimagwirira ntchito. Koma pa intaneti pamawebusayiti apadera azidziwitso ndi maforamu, mutha kupeza ndemanga zambiri zokhudzana ndi mankhwalawa. Mwambiri, ali ndi malingaliro.

Anandipeza ndi matenda a insulin. Kuti ndikhale ndi thanzi labwino, ndinkagwiritsa ntchito mankhwala akunja komanso akunja kwa nthawi yayitali, koma sizinachitike. Dokotala adandiuza "Trazhent", ndimamwa kwa mwezi umodzi, kuphatikiza ine ndimatsata kudya kosamalitsa. Munthawi yochepa iyi, ndidataya pafupifupi ma kilogalamu 4.5. Ndimakondwera kwambiri ndi zotsatira zake. Kumayambiriro kwa kumwa mankhwalawo panali zovuta zochepa zomwe zimatchulidwa pakufotokozera kwa mapiritsi, koma adadutsa mwachangu.

Mmawa wanga umayamba ndikumwa piritsi la "Diabeteson", madzulo ndimamwa "Trazhentu". Mlozera wa shuga ukuwonetsa 6-8 mmol / L. Popeza ndili ndi matenda ashuga omwe ndimakumana nawo, kwa ine izi ndi zotsatira zabwino. Popanda Trazhenta, glycated hemoglobin index sinatsike peresenti ya 9.3, tsopano ndi 6.4. Kuphatikiza pa matenda ashuga, ndimadwala matenda a pyelonephritis, koma Trazhenta sakhala wankhanza ku impso. Ngakhale mapiritsiwa ndi okwera mtengo kwa munthu amene amapuma pantchito, zotsatira zake zimakwaniritsa zoyembekezera zonse.

Petr Mikhailovich, wazaka 65 zakubadwa

Dokotala adalamula "Trazhenta" kukhazikika minofu ndi shuga. M'masiku oyambilira kugwiritsa ntchito mankhwala, zoyipa zimatchulidwa kwambiri. Ndidayenera kufunsa kuti ndipeze analog. Inde, ndipo okwera mtengo kwambiri "Trazhenta" awa.

Mtengo wa mankhwala opangira mankhwala opangira mankhwala amasiyana kuchokera ku 1480 mpaka 1820 rubles kuti mutayike No. 30. "Trazhenta" amagulitsidwa kokha kuchipatala.

Gulu la DPP-4 inhibitors, lomwe limaphatikizapo Trazhenta, lili ndi chiwonetsero chantchito komanso chitetezo. Mankhwala oterowo samapweteketsa zotsatira za hypoglycemic, musalimbikitse kulemera ndipo musakhale ndi vuto pa impso. Pakadali pano, gulu lapadziko lonse lapansi lamankhwala limatengedwa kuti ndilothandiza kwambiri komanso lolonjeza pankhani yokhudza kuyendetsa T2DM.