Kodi pali kusiyana kotani pakati pa atorvastatin ndi rosuvastatin?

High cholesterol ndimomwe imayambitsa matenda ambiri a mtima, bongo, zotumphukira. Atherosulinosis (kufalikira kwa cholesterol kukhoma kwa mitsempha) ndizomwe zimayambitsa kufa padziko lapansi ndi mayiko omwe kale anali Soviet Union. Statins ndi mankhwala omwe angaletse, ndikugwiritsa ntchito nthawi yayitali, aletse kukula kwa atherosulinosis. Kuyerekezera kwa Atorvastatin ndi Rosuvastatin, monga oimira awiri abwino pagululi, kukuthandizani kusankha mankhwalawa aliyense payekhapayekha.

Atorvastatin ndi rosuvastatin zimakhala ndizomwe zimagwira.

Njira yamachitidwe

Mankhwalawa onse ndi oimira gulu limodzi lamankhwala, motero momwe amagwirira ntchito akufanana. Kusiyana pakati pawo kuli mu mphamvu ya chochitikacho: kukwaniritsa zofanana ndi zotsatira zamankhwala, muyeso wa Rosuvastatin ukhoza kukhala theka la Atorvastatin.

Limagwirira a zochita zamankhwala kupondereza enzyme yomwe ikuphatikizidwa pakupanga cholesterol. Zotsatira zake, mulingo wa cholesterol wathunthu komanso wotsika kwambiri komanso wotsika kwambiri wa lipoproteins (LDL, VLDL), triglycerides amachepetsedwa. Ndizomwe zimayambitsa mapangidwe amitsempha yamagazi, kugunda kwa mtima, stroko, etc.

Mankhwala onsewa ayenera kugwiritsidwa ntchito pazinthu zotsatirazi:

• Kukwezeka kwathunthu mafuta m'thupi,
• Magawo okwera a LDL, VLDL, triglycerides,
• Matenda a mtima (kuperewera kwa magazi kwa minofu ya mtima) ndi mawonekedwe ake onse (kugunda kwa mtima, angina pectoris),
• Atherosulinosis ya msempha, ziwiya za m'munsi, ubongo, mafupa aimpso,
• Ndi kuthamanga kwa magazi - kuletsa kukula kwa atherosulinosis.

Contraindication

Atorvastatin sangathe kugwiritsidwa ntchito:

• Kusagwirizana ndi mankhwalawo,
• Matenda a chiwindi,
• Kuchepa kwa chiwindi,
• Mimba komanso kuyamwa.

• Kusagwirizana ndi mankhwalawo,
• Matenda a chiwindi,
• Kuchepa kwa chiwindi,
• Zowopsa zaimpso,
• Zowonongeka pamitsempha yamatumbo,
• Kutenga cyclosporine,
• Mimba komanso kuyamwa
• Zaka mpaka 18.

Zotsatira zoyipa

Atorvastatin ikhoza kuyambitsa:

• Mutu
• Zofooka
• Kusowa tulo
• Zowawa pachifuwa
• Kuchepa kwa chiwindi,
• Kutupa kwa ziwalo za ENT,
• Zodandaula
• Minofu ndi kupweteka kwa molumikizana
• Kutupa
• Thupi lawo siligwirizana.

Zotsatira zoyipa za rosuvastatin:

• Kukula kwa matenda osokoneza bongo (mellitus)
• Ululu m'mutu
• Zodandaula
• Kuchepa kwa chiwindi,
• Kupweteka kwa minofu
• Zofooka.

Tulutsani mafomu ndi mtengo

Mitengo ya mapiritsi a Atorvastatin imasiyana kwambiri malinga ndi wopanga:

• 10 mg, 30 ma PC. - 130 - 260 p,
• 10 mg, 60 ma PC. - 300 r
• 10 mg, ma PC 90. - 550 - 710 r,
• 20 mg, 30 ma PC. - 165 - 420 r,
• 20 mg, ma PC 90. - 780 - 1030 r,
• 40 mg, 30 ma PC. - 295 - 630 p.

Mtengo wa mapiritsi a rosuvastatin umasiyananso kwambiri:

• 5 mg, 28 ma PC. - 1970 p
• 5 mg, 30 ma PC. - 190 - 530 r,
• 5 mg, ma PC 90. - 775 - 1020 r,
• 5 mg, 98 ma PC. - 5620 r,
• 10 mg, 28 ma PC. - 420 - 1550 r,
• 10 mg, 30 ma PC. - 310 - 650 p,
• 10 mg, 60 ma PC. - 620 r
• 10 mg, ma PC 90. - 790 - 1480 r,
• 10 mg, 98 ma PC. - 4400 r,
• 10 mg, 126 ma PC. - 5360 r,
• 15 mg, 30 ma PC. - 600 r
• 15 mg, ma PC 90. - 1320 r,
• 20 mg, 28 ma PC. - 505 - 4050 r,
• 20 mg, 30 ma PC. - 400 - 920 p,
• 20 mg, 60 ma PC. - 270 - 740 r,
• 20 mg, ma PC 90. - 910 - 2170 r,
• 40 mg, 28 ma PC. - 5880 r,
• 40 mg, 30 ma PC. - 745 - 1670 r,
• 40 mg, ma PC 90. - 2410 - 2880 p.

Rosuvastatin kapena Atorvastatin - ndibwino?

Ngati mungasankhe mankhwala omwe ali abwino kuchokera kuchipatala, ndiye kuti ndi Rosuvastatin. Popeza imatha kumwa pang'onopang'ono, kuchuluka kwake ndi zotsatira zake ndizochepa kwambiri poyerekeza ndi Atorvastatin. Komabe, ndiokwera mtengo kwambiri, makamaka opangidwa ndi kampani Teva kapena Astrazenek (Krestor). Imwani mankhwala mwezi uliwonse, zomwe zimawonjezera chidwi kwa odwala ena zimangokulitsa. Pankhani imeneyi, atorvastatin amakhalabe statin yomwe imagwiritsidwa ntchito kwambiri.

Zomwe zili bwino: atorvastatin kapena rosuvastatin? Ndemanga

• Ndili ndi cholesterol yapamwamba kwambiri, bambo anga anamwalira ndi vuto la mtima pafupifupi zaka 40. Ndakhala ndikumwa Atorvastatin kwa nthawi yayitali, ndili pafupifupi 40 ndipo sindifa pano, zotengera zake sizabwino kwenikweni, koma nzolekerera
• Sindingathe kumwa mankhwalawa - chiwindi chimayamba kukhazikika, kufooka kumawonekera.
• Mankhwala achilendo kwambiri. Zotsatira zake sizimamva, koma madokotala onse amamukakamiza kuti atenge. Koma mayesowa ali bwino pambuyo pake.

• Sindine wokhoza kugwiritsa ntchito ndalama mwezi uliwonse, ngakhale ndimazikonda. Ndipo sindingathe kuyimirira Atorvastatin,
• Kusintha kwakukulu kwa atorvastatin: Mlingo wotsika, wopilira bwino,
• Sindikumvetsa kuti bwanji kulipira ndalama zamisala ngati mutha kumamwa zotsika mtengo.

Kodi ma statins ndi ati?

Statin imaphatikizapo gulu lalikulu la mankhwala omwe amagwiritsidwa ntchito kuti achepetse kuchuluka kwa LDL ndi VLDL m'magazi.

Muzochitika zamankhwala zamakono, ma statins sangathe kugawidwa pothana ndi matenda a atherosulinosis, hypercholisterinemia (osakanikirana kapena homozygous), komanso matenda a mtima.

Mwambiri, mankhwalawa a gululi ali ndi zofanana zochizira, i.e. m'munsi LDL ndi VLDL. Komabe, chifukwa cha magawo osiyanasiyana ogwira ntchito ndi othandiza, pali zosiyana zomwe zimayenera kukumbukiridwa kuti tipewe zovuta.

Statin nthawi zambiri amagawika I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) ndi m'badwo wa IV (Pitavastatin, Rosuvastatin).

Statin akhoza kukhala achilengedwe komanso opanga. Kwa katswiri, kusankha kwa mankhwala otsika kapena ochepa, ndikofunikira kwambiri kwa wodwala.

Rosuvastatin ndi Atorvastatin nthawi zambiri amagwiritsidwa ntchito kutsitsa cholesterol. Aliyense wa mankhwalawa ali ndi mawonekedwe:

Rosuvastatin amatanthauza ma statins a m'badwo wachinayi. Wothandizila lipid-wotsitsa amapangidwa kwathunthu ndi pafupifupi Mlingo wothandizira. Zimapangidwa pansi pa zizindikiro zosiyanasiyana, mwachitsanzo, Krestor, Mertenil, Rosucard, Rosart, ndi zina zambiri.

Atorvastatin ndi wa m'badwo wachitatu wa statins. Monga analogue yake, ili ndi chiyambi chopangidwa, koma imakhala ndi mlingo waukulu wa zomwe zimagwira.

Pali maulumikizano amtundu wa mankhwala monga Atoris, Liprimar, Toovacard, Vazator, etc.

The mankhwala zikuchokera mankhwala

Mankhwala onsewa amapezeka piritsi. Rosuvastatin imapangidwa mumagulu angapo - 5, 10 ndi 20 mg ofanana. Atorvastatin imamasulidwa mu gawo la 10,20,40 ndi 80 mg yogwira mankhwala. Pansipa pali tebulo loyerekeza magawo othandizira aomwe amadziwika ndi ma statins.

Kusiyana kwakukulu pakati pa Rosuvastatin ndi Atorvastatin ndizinthu zawo zachilengedwe. Ubwino wa rosuvastatin ndikuti umasweka mosavuta m'madzi amadzi ndi madzi ena, i.e. ndi hydrophilic. Atorvastatin ali ndi gawo lina: limasungunuka m'mafuta, i.e. ndi lipophilic.

Kutengera izi, mphamvu ya Rosuvastatin imangodalira maselo a chiwindi parenchyma, ndi Atorvastatin - ku kapangidwe ka ubongo.

Pharmacokinetics ndi pharmacodynamics - kusiyana

Poyamba pa magawo a mapiritsi, pali kusiyana kwa mayamwidwe. Chifukwa chake, kugwiritsa ntchito rosuvastatin sikudalira nthawi yamasana kapena chakudya. Atorvastatin sayenera kudyedwa nthawi yomweyo ndi chakudya, monga izi zimakhudza mayamwidwe a chigawocho. Zambiri zomwe zili ku Atorvastatin zimatheka pambuyo pa maola 1-2, ndi Rosuvastatin - atatha maola 5.

Kusiyana kwina pakati pa ma statins ndi kagayidwe kake. Mthupi la munthu, Atorvastatin amasinthidwa kukhala mawonekedwe osagwira ntchito pogwiritsa ntchito ma enzymes a chiwindi. Chifukwa chake, ntchito ya mankhwalawa imakhudzana mwachindunji ndi kugwira ntchito kwa chiwindi.

Amapangidwanso ndi mankhwala omwe amagwiritsidwa ntchito nthawi yomweyo ndi Atorvastatin. Analogue yake, m'malo mwake, chifukwa cha kuchuluka kwa mankhwalawa, sikuti amachita ndi mankhwala ena. Ngakhale izi sizimamupulumutsa iye kuchokera kukhalapo koyipa.

Atorvastatin amapukusidwa makamaka ndi bile.

Mosiyana ndi ma statins ambiri, Rosuvastatin pafupifupi samapangidwira m'chiwindi: zoposa 90% za zinthu zimachotsedwa osatembenuka ndi matumbo ndipo ndi 5-10% yokha impso.

Kugwiritsa Ntchito Maganizo Abwino

Ntchito yayikulu ya mankhwala a statin ndikuchepetsa kuchuluka kwa LDL m'magazi ndikuwonjezera kuchuluka kwa HDL.

Chifukwa chake, kusankha pakati pa Atorvastatin ndi Rosuvastatin, tiyenera kuyerekezera momwe amachepetsa cholesterol.

Kafukufuku waposachedwa wasayansi watsimikizira kuti rosuvastatin ndi mankhwala othandiza kwambiri.

Zotsatira zakuchipatala zafotokozedwera pansipa:

1. Pokhala ndi Mlingo wofanana wamankhwala, Rosuvastatin amachepetsa cholesterol ya LDL ndi 10% bwino kwambiri kuposa analogue yake. Ubwino uwu umalola kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi hypercholesterolemia.
2. The pafupipafupi chitukuko cha mtima mavuto ndi isanayambike wakupha zotsatira kwambiri mu Atorvastatin.
3. Vutoli limayambira modabwitsa.

Kuyerekeza mphamvu yakuchepetsa kuchuluka kwa cholesterol "yoyipa" kumatsimikizira kuti Rosuvastatin ndi mankhwala othandiza kwambiri. Komabe, munthu sayenera kuyiwala za zinthu monga kukhalapo kwa contraindication, mavuto ndi mtengo wake. Poyerekeza mitengo ya mankhwalawa imaperekedwa patebulopo.

Chifukwa chake, atorvastatin ndi analogue yotsika mtengo yomwe anthu ochepa ndalama sangakwanitse.

Ndi zomwe odwala amaganiza za mankhwala osokoneza bongo - Rosuvastatin amalekeredwa bwino komanso popanda mavuto. Ikatengedwa, cholesterol yoyipa imachepetsedwa

Kuyerekezera kwa mankhwalawa kumathandiza kuzindikira kuti pakadali pano pa chitukuko cha mankhwala, malo oyamba pakati pa mapiritsi abwino kwambiri a cholesterol amakhala ndi ma statins a m'badwo wachinayi, kuphatikiza Rosuvastatin.

Pankhani ya mankhwala Rosuvastatin ndi mawonekedwe ake afotokozedwa mu kanema munkhaniyi.