Tsifran ": Malangizo ogwiritsira ntchito, zikuwonetsa ndi zotsutsana

Cifran ndi mankhwala opangidwa ndi imodzi mwa makampani akuluakulu opanga mankhwala ku India, Ranbaxy Laboratories Ltd.

Chothandizira cha Cifran ndi ciprofloxacin hydrochloride (wofanana ndi 500 mg ciprofloxacin), womwe umagwiritsidwa ntchito pochiza matenda a bacteria.

Machitidwe

Ciprofloxacin ndi wa gulu la mankhwala omwe amatchedwa quinolones / fluoroquinolones. Amalepheretsa kupumula kwa DNA ndikulepheretsa DNA gyrase kuzinthu zowoneka bwino, zimathandizira "kuwonongeka" kwa DNA yopanga-kawiri. Wopangidwa mu chiwindi, theka-moyo: (mwa ana), (mwa akulu). Chotupa: ndowe ndowe

Zizindikiro zogwiritsidwa ntchito kwa akuluakulu:

matenda a bronchial
Matenda a ENT
mano ndi flux (makamaka),
typhoid fever chifukwa cha typhoid salmonella,
chinzonono
matenda amaso
chifuwa chachikulu
mabakiteriya am'mimba oyambitsidwa ndi Escherichia coli, Campylobacter Euni kapena mitundu yosiyanasiyana ya Shigella,
matenda a impso
bakiteriya matenda am'mimba,
sepsis
matenda a mafupa ndi mafupa oyambitsidwa ndi enterobacter cloaca, serging ya marcescens kapena Pseudomonas aeruginosa,
zotupa zofewa komanso kapangidwe ka khungu,
anthrax.

Zisonyezero zogwiritsira ntchito "Tsifran" kwa ana:

Kuchiza ndi kupewa anthrax.
Mavuto obwera chifukwa cha Pseudomonas aeruginosa mwa ana azaka 5 mpaka 17 omwe ali ndi cystic fibrosis (cystic fibrosis) yamapapu.

"Tsifran" imapezeka mu mawonekedwe a mapiritsi okhala ndi filimu mu Mlingo wa 250 mg ndi 500 mg, mu mawonekedwe a madontho amaso ndi mawonekedwe a kulowetsedwa kwa anthu ambiri.

"Tsifran": Malangizo ogwiritsira ntchito pathupi pathupi komanso mkaka wa m'mawere

Maphunziro ambiri sanapeze chiopsezo chowonjezereka cha kubadwa kwatsopano pomwe azimayi amatenga mankhwala a chiprofloxacin kapena mankhwala ena a quinolone / fluoroquinolone panthawi yoyamba kubereka. Popeza maphunziro awa anaphatikiza azimayi omwe amatenga ciprofloxacin, zotsatira za kugwiritsa ntchito nthawi yayitali kwa Cifran sizikudziwika. Komabe, panalibe chiwopsezo chowonjezereka cha zilema zakubadwa mwa ana ochepa omwe amakhala ndi nthawi yayitali yogwiritsira ntchito ciprofloxacin.

Ndi dokotala wokhayo amene amayang'anitsitsa mkaziyo panthawi yoyembekezera komanso mkaka wa m`mawere ndi omwe amatha kusankha ngati mapindu a cyfran kwa mayi ndi omwe amapitilira chiwopsezo cha mankhwala kwa mwana wosabadwayo.

Zotsatira zoyipa zingapo zimatha kugwiritsidwa ntchito ndi cyfran. Zodziwika kwambiri ndi izi:

nseru
mutu
zotupa
redness pakhungu (makamaka likayatsidwa ndi dzuwa). Ndikofunika kugwiritsa ntchito mawonekedwe a dzuwa mutatuluka kunja mutatha "Tsifran"
kulawa kwazitsulo mkamwa
kusanza
kupweteka m'mimba
kutsegula m'mimba

Zotsatira zoyipa zazikulu (zosowa, koma osaphatikizidwa):

Zingwe.
Kukhumudwitsa.
Zotupa pakhungu.
Kuwonongeka kwa chiwindi, komwe kumawonetsedwa ndi zizindikiro zotsatirazi: jaundice (chikasu cha khungu ndi maso), mkodzo wakuda, nseru, kusanza, kuperewera, kupweteka pamimba.
Tendon edema, makamaka mwa azimayi azaka zopitilira 60. Edema, nawonso, amawonjezera kupezeka kwa kupindika kwa tendon panthawi yolimbitsa thupi. Tendon edema imatha kuchitika miyezi yambiri kugwiritsa ntchito ntchito ya cyfran.
Ngakhale Cifran amagwiritsidwa ntchito pochiza matenda omwe amayamba chifukwa cha kuchuluka kwa maselo oyera oyera, amatha payekha kuchepetsa kuchuluka kwa maselo oyera amthupi. Izi zimadzetsa kuwonongeka kwa chitetezo cha mthupi, komanso zimawonjezera kukhudzika kwa wodwala matenda.
Photosensitivity (chodabwitsa kwambiri pakuwona kuwala kwa dzuwa).
Zizindikiro zikuwonjezeka mwa odwala omwe ali ndi matenda amisala. Izi zimatha kubweretsa malingaliro ofuna kudzipha.

Zoyipa:

Matupi a ziwengo kwa ciprofloxacin.
Myasthenia gravis (matenda a autoimmune a neuromuscular system).
Khunyu
Matenda a mtima.
Impso kapena matenda a chiwindi.

Sayenera kuphatikizidwa ndi mankhwala otsatirawa:

"Tizanidine" - amagwiritsidwa ntchito pofuna kuchiza minofu. Zowopsa: chiwopsezo cha mavuto obwera chifukwa chofotokozera za "Tsifran" (malangizo ogwiritsira ntchito) akuwonjezeka.
"Warfarin" ndi mankhwala omwe amagwiritsidwa ntchito pochotsa magazi m'magazi. Kuopsa: Chiwopsezo chowonjezeka magazi.
"Theophylline" - amagwiritsidwa ntchito potsegula misewu ya mankhwalawa pochiza mphumu. Zowopsa: Kugwiritsa ntchito pamodzi "Theophylline" ndi "Tsifran" kungayambitse kukhudzidwa, komanso kuphwanya mzere wamtima.
Sildenafil ("Viagra") ndi mankhwala ogwiritsidwa ntchito pochotsa kukanika kwa erectile. Zowopsa: kuchuluka kwa sildenafil m'magazi, kupezeka kwa zovuta za Viagra kungachitike.
"Pentoxifylline-Teva" - imagwiritsidwa ntchito kukonza njira zotumphukira. Zowopsa: mulingo wa mankhwalawa m'magazi umakwera ndipo chiopsezo cha zotsatira zoyipa chikuwonjezeka.
"Omeprazole" ndi mankhwala omwe amagwiritsidwa ntchito kupha Helicobacter pylori ndikuchiza matenda a gastroesophageal Reflux. Zowopsa: mulingo wa "Tsifran" m'mwazi umachepa, potero umakulitsa mphamvu ya mankhwalawa.
Calcium, magnesium kapena chitsulo kukonzekera (kuphatikiza mawonekedwe a mapiritsi a efflementscent). Zowopsa: kugwira ntchito kwa Tsifran kumachepa.
Maantacid ndi mankhwala omwe amasokoneza asidi m'mimba. Zowopsa: magwiridwe a "Tsifran.
Mapiritsi a Cifran amatha kuonjezera mphamvu ya caffeine.

Odwala omwe akuchitidwa opaleshoni (kuphatikizapo opaleshoni yamano) ayenera kuchenjeza opaleshoni kapena opaleshoni yokhudza kumwa Cifran. Mankhwalawa amathanso kukhudza mankhwala ena omwe amagwiritsidwa ntchito pochita opareshoni.

Ngakhale kuti mankhwalawa amagwiritsidwa ntchito ngati ali ndi mabakiteriya ena, sikugwiranso ntchito nthawi zonse, chifukwa chake ndikofunikira kuti adotolo apereke mayeso kuti adziwe momwe angafotokozere Cyfran. Malangizo ogwiritsira ntchito samaphatikizapo zizindikiro zingapo, komanso ma contraindication ambiri, chifukwa chake musadziyese.

Momwe mungatenge "Tsifran" ndi prostatitis ndi matenda ena

Tsoka ilo, silikhala ndi ntchito yambiri yolimbana ndi mabakiteriya a anaerobic (chlamydia ndi mycoplasma), omwe amalola kuti tizilombo toyambitsa matenda tidziyambitse mu Prostate, ndipo maphunziro obwereza a Cyphran amalephera ndipo nthawi yofunikira yamankhwala imawonongeka.

Kwa akulu omwe ali ndi zizindikiro zoyambirira za bakiteriya a prostatitis, mapiritsi a Cifran nthawi zambiri amapatsidwa mlingo wa 500 mg kawiri pa tsiku kwa masabata awiri kapena anayi. Komabe, malangizo enieni a momwe mungatengere "Tsifran" kwa wodwala amaperekedwa ndi a urologist, potengera kuwopsa kwa matendawa.

Kafukufuku ku South Korea adawonetsa kuti kuphatikiza kwa adyo ndi ciprofloxacin kunali kwabwino kuposa ciprofloxacin kokha pochiza matenda a bacteriitis a bacteria. Ofufuzawo adayesa kuti mankhwala a adalicrobial komanso odana ndi kutupa, komanso mphamvu ya adyo, komanso ciprofloxacin mu makoswe akuluakulu amuna omwe ali ndi bacteriititis ya bacteria.

Makoswe okwanira 41 omwe ali ndi matendawa adagawidwa mosawerengeka m'magulu anayi a chithandizo: kuwongolera, adyo, omwe amangolandira liprofloxacin, ndi omwe adalandira adyo kuphatikiza kuprofloxacin. Pambuyo pa milungu itatu yamankhwala, makoswe omwe ali mgulu la adyo anali ndi kuchepa kwakukulu kwa kuchuluka kwa mabakiteriya ndipo panali kuwongolera kwa zizindikiro za kutupa kwa prostate poyerekeza ndi gulu lolamulira. Komabe, pagululi lomwe linapatsidwa adyo kuphatikiza chiprofloxacin, panali kuchepa kwakukulu kwa kukula kwa bakiteriya ndikusintha kwakukulu pazizindikiro za kutupa kwa prostate poyerekeza ndi gulu lomwe limathandizidwa ndi ciprofloxacin.

Zotsatira izi zikuwonetsa kuti adyo amatha kupereka zabwino komanso zotsutsana ndi kutupa, komanso synergistic kwambiri ndi ciprofloxacin.

Odwala omwe ali ndi prostatitis akutenga Cifran nthawi zambiri amadandaula za mavuto monga nseru (2,5%), kutsegula m'mimba (1.6%), kusanza (1%), ndi zotupa (1%).

Momwe mungatenge "Tsifran" pakamwa

Mankhwala akuluakulu omwe amalimbikitsidwa amachokera ku 250 mg mpaka 750 mg kawiri tsiku lililonse. Kutengera mtundu wa matenda omwe muyenera kulandira, mungafunike kutenga Cifran kuyambira masiku atatu mpaka 28.
Ndi cosstitis yosavuta, chithandizo cha maphunzirowa chimatha masiku atatu, ndi mitundu yochepa kapena yowopsa
Ndi urethritis, chithandizo chake chimatenga masiku 8 mpaka 10.
Ndi otitis media, tonsillitis, tonsillitis, njira ya chithandizo, pafupifupi, masiku 5.
Ngati muli ndi matenda am'mimba, malingana ndi kuuma, mankhwalawa amatenga masiku 7 mpaka 28.
Njira ya mankhwala "Tsifranom" kwamikodzo matenda
Ndi matenda amfupa ndi olowa, zingakhale zofunika kutenga "Tsifran" kwa miyezi ingapo.
Mapiritsi sayenera kutafunidwa; amakhala ndi kukoma kosasangalatsa.
Mapiritsi a Cifran amatha kumwa ndi chakudya kapena pamimba yopanda kanthu.
Ngakhale ciprofloxacin imatha kumwa ndi zakudya zomwe zimaphatikizapo mkaka, simuyenera kumwa nokha mkaka kapena zakudya zopangidwa ndi calcium.
Simungathe kumwa ma antacid, othandizira ndi calcium, magnesium, chitsulo kapena ma multivitamini 6 maola asanafike kapena maola awiri mutatha "Tsifran".

Momwe mungatenge "Tsifran" kudzera m'mitsempha:

Mulingo woyenera wa kulowetsedwa mankhwala (mankhwalawa intravenous solution) "Tsifran" mu matenda owopsa
Intravenra, "Tsifran" imayendetsedwa pakanthawi kochepa (kuyambira mphindi 30 mpaka ola limodzi).
Kulowetsedwa kwa Tsifran kumakhala ndi 0,9% w / v sodium chloride solution.
Kulowetsedwa uku kumagwirizana ndi madzi onse amkati.

"Tsifran": Mlingo wa akulu ndi ana, mtengo wake ndi mapikiselo a mankhwala

Njira ya mankhwalawa komanso mtundu wa cyfran zimatengera mtundu wa bakiteriya.

Mlingo wofotokozedwa ndi adotolo ukhoza kusiyana ndi zomwe zawonetsedwa munkhaniyi.

Tsatirani zonena za adotolo chimodzimodzi.

"Tsifran": Mlingo wa akulu:

Pachimake sinusitis (wofatsa kapena wolimbitsa): 500 mg kawiri tsiku lililonse kapena 400 mg kawiri tsiku lililonse kulowetsedwa (kudzera m`mitsempha) kwa masiku 10. Kuchokera pamilomo y kulowetsedwa pakamwa yogwiritsira ntchito "Tsifran" imasiyana chifukwa mankhwalawa amaperekedwa kudzera mwa dontho.
Mafupa ndi mafupa ophatikizika (ofatsa kapena okwanira): 500 mg kawiri tsiku lililonse kapena 400 mg kulowetsedwa kawiri tsiku lililonse kwa masiku 30.
Bakiteriya matenda a prostatitis (ofatsa kapena olimbitsa). Mlingo umawonetsedwa kwa bacteriitis yodwala yomwe imayambitsidwa ndi Escherichia coli kapena Proteus Mirabilis: 500 mg kawiri tsiku lililonse kapena 400 mg kulowetsedwa kawiri tsiku lililonse kwa masiku 28.
Media otitis media: 500 mg kawiri tsiku lililonse kapena 400 mg kulowetsedwa kawiri tsiku lililonse
Matenda opatsirana opatsirana: 500 mg kawiri tsiku lililonse
Matenda am'mapapo ochepa. (Ofatsa kapena ochepa): 500 mg kawiri tsiku lililonse kapena 400 mg kulowetsedwa kawiri tsiku lililonse kwa sabata limodzi kapena awiri.
Matenda a pakhungu (ofatsa kapena opatsa mphamvu): 500 mg kawiri tsiku lililonse kapena 400 mg kudzera kawiri pa tsiku kwa sabata limodzi kapena awiri.
Matenda amitsempha yam'mimba (ofatsa / osavuta): 250 mg kawiri tsiku lililonse kwa masiku atatu.
Matenda a urethral ndi gonococcal (osavuta): kamodzi.
Anthrax, postexposure chithandizo ndi prophylaxis: 500 mg kawiri tsiku lililonse kapena 400 mg kulowetsedwa tsiku lililonse kwa masiku 60.

Odwala okalamba amapatsidwa mapiritsi ochepa a Cyfran. Mlingo umawerengeredwa potengera kuopsa kwa zizindikiro ndi chizindikiro cha matendawa, komanso chidziwitso cha creatinine. Mwachitsanzo, ngati chizindikiro ichi chikuchokera 30 mpaka 50 ml / min, mlingo wa Cyfran umachokera ku 250 mpaka 500 mg kawiri pa tsiku.

"Tsifran" sindiyo kusankha koyamba mwa ana (kupatula anthrax), chifukwa cha kuchuluka kwa zotsatira zoyipa (kuphatikizapo arthropathy) poyerekeza ndi gulu loyang'anira. Palibe dosing deta ya odwala omwe ali ndi vuto la impso.

"Tsifran": Mlingo wa ana kuyambira zaka 5 mpaka 17:

Pulmonary anthrax (mankhwala ozizira pambuyo pake).
Njira yothetsera kulowetsedwa: pa mlingo wa 10 mg / kg, kawiri pa tsiku, kwa miyezi iwiri. Mlingo wa munthu sayenera kupitirira 400 mg.
Mapiritsi: pa 15 mg / kg, kawiri pa tsiku kwa miyezi iwiri, munthu sayenera kupitirira 500 mg.
Cystic fibrosis.
Mapiritsi: pa 40 mg / kg / tsiku, kawiri pa tsiku. Mlingo wa munthu sayenera kupitirira 2 g / tsiku.
Njira yothetsera kulowetsedwa: kg / tsiku lililonse, maola 8 aliwonse. Mlingo wa munthu sayenera kupitirira 1,2 g / tsiku.

Mankhwala ambiri osokoneza bongo a ciprofloxacin angayambitse kuwonongeka kwa impso.

Mu maphunziro a nyama, Mlingo waukulu kwambiri wa ciprofloxacin unayambitsa kupuma, kusanza, komanso kupweteka.

Analogs of "Tsifran":

Mapiritsi a Baycip - 500 mg. Wopanga - Bayer.
Mapiritsi a Cebran - 500 mg. Wopanga - Blue Corss.
Mapiritsi a Ciplox - 500 mg. Wopanga - Cipla.
Mapiritsi a Ciprowin - 500 mg. Wopanga - Alembic Pharma.
Mapiritsi a Alcipro - 500 mg. Wopanga - Ma Alkem Labs.
Mapiritsi a Cipronat - 500 mg. Wopanga - Natco Pharma.
Mapiritsi a Ciprofen - 500 mg. Wopanga - Franklin Labs.
Mapiritsi a Ciprobid - 500 mg. Wopanga - Cadila Pharma.
Mapale a Quintor - 500 mg. Wopanga - Torrent Pharma.
Makutu ndi dontho la dontho "Betaciprol" - 0,3%. Wopanga - Beta Lek.
Ificipro kulowetsedwa Solution - 2 mg / ml. Wopanga - UNIQUE PHARMACEUTICAL Laboratories.

Mtengo wa "Tsifran" m'mafakitala osiyanasiyana ku Russia umasiyana ndi ma ruble 51 (pamapiritsi 10 a 250 mg aliyense) mpaka 92 ruble (pamapiritsi okhala ndi mlingo wa 500 mg aliyense).

Mtengo wa "Tsifran" mwanjira yothetsera jakisoni umachokera ku ruble 44 mpaka 56.

Mtengo wa "Tsifran" mwanjira ya madontho amaso ndikuchokera ku ma ruble 48 mpaka 60.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wa kutulutsidwa kwa Tsifran ST - mapiritsi okhala ndi matendawa: mapiritsi 250 mg + 300 mg - achikasu, oval, mapiritsi 500 500 + 600 mg - chikasu, chowunikira, mbali imodzi ndi mzere wogawika (pamatafulati a makatoni a 1, 2 kapena 10 matuza Ma PC 10.).

Zinthu zomwe zimagwira piritsi limodzi:

ciprofloxacin - 250 kapena 500 mg (monga hydrochloride monohydrate),
Tinidazole BP - 300 kapena 600 mg.

pachimake: sodium lauryl sulfate, sodium starch glycolate, cellcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate,
zigawo zakunja kwa michere: sodium wowuma glycolate, oyeretsa talc, sodium lauryl sulfate, microcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate,
chipolopolo: Opadry wachikasu, madzi oyeretsedwa.

Mankhwala

Cifran ST ndi imodzi mwazophatikiza zomwe zida zake zogwira - tinidazole ndi ciprofloxacin - zimagwiritsidwa ntchito pochiza matenda omwe amayamba chifukwa cha aerobic ndi anaerobic tizilombo.

Zomwe zimagwiritsidwa ntchito ndizofunikira:

Pharmacokinetics

Zinthu zofunikira zimayamwa bwino m'mimba. Kuzungulira kwakukulu (C_max) chilichonse mwazinthuzi zimatheka mkati mwa maola 1-2.

Bioavailability ndi 100%, kumangiriza kwa mapuloteni a plasma kuli pafupifupi 12%. Kutha kwa theka-moyo kuli pamtunda kuchokera maola 12 mpaka 14.

Imalowa mkatikati mwa ziwalo zathupi ndikufika pamwamba kwambiri pamenepo.Imalowa m'madzi amadzimadzi am'madzi amtundu wofanana ndi plasma ndende, imabwezedwa m'mbuyo.

Imafukusidwa mu ndulu mumakakanda pang'onopang'ono 50% ya ndende yake m'magazi. Pafupifupi 25% ya mankhwalawa amatengedwa ndi impso osasinthika. Tinidazole metabolites chifukwa 12% ya mankhwala omwe amaperekedwa; amathandizanso impso. Kuphatikiza apo, tinidazole pang'ono amachotsedwa kudzera m'mimba.

Ciprofloxacin

Pambuyo pakumwa pakamwa, imamwa bwino. Bioavailability pafupifupi 70%. Pogwiritsa ntchito nthawi yomweyo ndi chakudya, kuyamwa kwa zinthu kumachepetsa. Pakati pa 20 ndi 40% ya ciprofloxacin imamangiriza mapuloteni a plasma.

Amalowa bwino m'madzi a mthupi ndi minyewa - khungu, mapapu, mafuta, cartilage, mafupa ndi minofu, komanso ziwalo zamkati mwa genitourinary system, kuphatikizapo gland ya prostate. Mitundu yambiri ya ciprofloxacin imapezeka pamatope, bronchi, mphuno, lymph, peritoneal fluid, seminal fluid, ndi bile.

Ciprofloxacin imapangidwa pang'ono ndi chiwindi. Pafupifupi 50% ya dozi imachotsedwa ndi impso osasinthika, 15% - mu mawonekedwe a metabolites yogwira, makamaka, oxociprofloxacin. Mlingo wina wonsewo umachotsedwamo mu ndulu, pang'ono pang'ono. Kuchokera m'mimba thirakiti, 15 mpaka 30% ya ciprofloxacin imachotsedwa. Hafu ya moyo pafupifupi maola 3.5-5.5.

Kwa odwala okalamba komanso chifukwa cha matenda aimpso kwambiri, theka limatha kukhala lalitali.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Tsifran ST imapangidwira zochizira matenda osakanikirana a bakiteriya omwe amayambitsidwa ndi ma gram-positive / gram-negative tizilombo, poyanjana ndi anaerobic ndi aerobic tizilombo ndi / kapena protozoa:

Matenda a ENT: sinusitis, atitis media, tonsillitis, pharyngitis, mastoiditis, frontus sinusitis, sinusitis,
zotupa za pakhungu / zofewa: zilonda zoperewera, zilonda zam'mimbazi zam'mimba komanso matenda am'mimba am'mimba, mabala, mabedi, zotupa, kupsya, phlegmon,
matenda amkamwa: periostitis, periodontitis, pachimake zilonda zam'mimba,
matenda amchiberekero ndi ziwalo zamkati, kuphatikiza ndi trichomoniasis: salpingitis, tubular abscess, pelvioperitonitis, oophoritis, endometritis, prostatitis,
matenda am'mafupa ndi mafupa: osteomyelitis, septic nyamakazi,
matenda am'mimba: shigellosis, typhoid fever, amoebiasis,
kwamikodzo thirakiti ndi matenda a impso: cystitis, pyelonephritis,
zovuta zamkati pamimba,
matenda ochepa kupuma thirakiti: pachimake ndi chodwala (panthawi ya kukokomeza) bronchitis, bronchiectasis, chibayo,
Nthawi pambuyo opaleshoni kuchitapo kanthu (kupewa matenda).

Contraindication

matenda a magazi, chopewera mafupa hematopoiesis,
organic zotupa zamanjenje,
pachimake porphyria
lactose tsankho, kufupika kwa lactase, shuga-galactose malabsorption,
kuphatikiza mankhwala ndi tizanidine (monga kuphatikizika kwa kuchepa kwa magazi ndi kukula kwa kugona kwambiri),
wazaka 18
Mimba ndi kuyamwa
tsankho limodzi ndi zigawo za mankhwala, komanso fluoroquinolones ndi imidazoles.

Wachibale (Tsifran ST woikidwa moyang'aniridwa ndi achipatala):

ngozi yamatenda,
zotupa za tendon zam'mbuyomu fluoroquinolone mankhwala,
matenda amitsempha yamagazi
matenda a mtima (kulowerera m'mitsempha, kufooka kwa mtima, bradycardia),
kutalika kwatsopano kwa nthawi ya QT,
electrolyte imbalance, kuphatikizapo hypokalemia, hypomagnesemia,
matenda amisala
kwambiri aimpso / chiwindi kulephera,
khunyu, khunyu,
kuphatikiza mankhwala ndi mankhwala omwe amakulitsa nthawi ya QT, kuphatikiza mankhwala othandizira a class IA ndi III,
kuphatikiza mankhwala ndi zoletsa za CYP4501A2 isoenzymes, kuphatikizapo theophylline, methylxanthine, caffeine, duloxetine, clozapine,
ukalamba.

Malangizo ogwiritsira ntchito Tsifran ST: njira ndi mlingo

Cifran ST imatengedwa pakamwa ndi madzi okwanira, makamaka atatha kudya. Kutafuna, kuswa, kapena kuwononga piritsi sikuyenera kutero.

Mlingo Wovomerezeka wa Tsifran ST:

250 mg + 300 mg: mapiritsi 2 kawiri pa tsiku,
500 mg + 600 mg: 2 kawiri pa tsiku piritsi limodzi.

Zotsatira zoyipa

mantha dongosolo: vertigo, mutu, chizungulire, kusokonezeka kwa kayendedwe (kuphatikizapo locomotor ataxia), dysesthesia, hypesthesia, hyperesthesia, paresthesia, disorielong, kusokonezeka kwa mitsempha, kufooka, kufooka, kupsinjika, kupsinjika, kufooka kwa mafupa, kusowa tulo, chisokonezo, malodza, kuchuluka kwa chidwi cham'mimba, mitsempha yam'mimba, kukomoka, migraine, kukwiya, nkhawa, kukhumudwa, kuyerekezera zinthu zina, komanso kuwonetsa zina. th (nthawi zina kupita patsogolo komwe wodwala amadzivulaza), polyneuropathy, zotumphukira paralgesia,
kugaya chakudya: kuchepa kwa chilakolako cha chakudya, xerostomia, kutsekemera kwazitsulo mkamwa, kupweteka kwam'mimba, mseru, kutulutsa m'mimba, kusanza, chifuwa, hepatonecrosis, hepatitis, flatulence, cholestatic jaundice (makamaka odwala omwe ali ndi matenda am'mbuyomu),
mtima: kuchepa kwa kuthamanga kwa magazi, kusokonezeka kwa mtima, mtima, tachycardia, kutalika kwa nthawi ya QT pa electrocardiogram, ventricular arrhythmias (kuphatikizapo mtundu wa pirouette),
hematopoietic dongosolo: granulocytopenia, leukocytosis, seramu matenda, hemolytic kuchepa magazi, neutropenia, agranulocytosis, vasodilation, pancytopenia, zoletsa za m'matumbo hematopoiesis, thrombocytosis, thrombocytopenia, leukopenia, kuchepa magazi,
ziwalo zam'malingaliro: kununkhira / kusokonekera, tinnitus, kusamva / kuwonongeka, kuwonongeka kwa mawonekedwe (mwa mawonekedwe a diplopia, kusintha kwa mawonekedwe amtundu, kuwonjezereka kwa photosensitivity),
kupuma dongosolo: mavuto kupuma (kuphatikizapo bronchospasm),
kwamikodzo dongosolo: kwamikodzo posungira, polyuria, kuperewera kwa impso, hematuria, kuchepa kwa nayitrogeni exretory ntchito ya impso, crystalluria (ndi kuchepa kwa mkodzo potulutsa mkodzo wa zamchere), glomerulonephritis, dysuria,
minofu: mafupa a chiwindi: kuchuluka kwa minyewa ya minyewa, kukweza minofu, kupindika kwa tendon, arthralgia, tendovaginitis, nyamakazi, myalgia, kufooka kwa minofu.
magawo a labotale: hypercreatininemia, hyperglycemia, hyperbilirubinemia, hypoprothrombinemia, kuchuluka kwa amylase, alkaline phosphatase, hepatic transaminases,
matupi awo sagwirizana: urticaria, pruritus, mapangidwe a matuza, omwe amathandizira kukhetsa magazi, komanso timinofu tating'onoting'ono tomwe timapanga mapasa, timatumbo tambiri pakhungu (petechiae), kutentha kwa mankhwala, laryngeal / nkhope yodwala, kufupika, vasculitis, eosinophilia, erythema nodosum epermermal necrolysis (matenda a Lyell), erythema multiforme exudative (kuphatikizapo Stevens-Johnson syndrome), anaphylactic mantha, anaphylactic reaction,
ena: kutuluka thukuta kwambiri, kusefukira kwa nkhope, asthenia, mphamvu zapamwamba (kuphatikizapo pseudomembranous colitis, candidiasis).

Bongo

Palibe mankhwala enieni, motero, ngati munthu ali ndi mankhwala osokoneza bongo ochulukirapo, akuwonetsa kuti ali ndi mankhwala otsatirawa, kuphatikiza njira zotsatirazi: kukomoka kwa m'mimba kapena kusanza, miyeso yokwanira kuphatikiza thupi (mokwanira mankhwala), ndi chithandizo chothandizira.

Mothandizidwa ndi hemo- kapena peritoneal dialysis, tinidazole ikhoza kuthetsedwa kwathunthu kuchokera mthupi, ciprofloxacin pang'ono (pafupifupi 10%).

Malangizo apadera

Panthawi yamankhwala, kuyang'ana kwambiri dzuwa kumalimbikitsidwa kupewedwa, chifukwa pali mwayi wopanga chithunzithunzi cha zithunzi. Zikuwoneka, Tsifran ST ichotsedwa pomwepo.

Kuti muchepetse kuchepa kwa magazi, sizingatheke kupitirira tsiku lililonse. Komanso, wodwalayo ayenera kuwonetsetsa kuchuluka kwamadzi komanso kusamalira mkodzo wa acidic. Kumwa mankhwalawa kumapangitsa kuti madontho a mkodzowo amdima.

Nthawi zina, munthawi ya mankhwalawa, chitukuko cha zovuta monga generalized urticaria, kutsitsa magazi, kutupa kwa nkhope / larynx, dyspnea ndi bronchospasm chimadziwika. Ngati mumadwala mtundu uliwonse wa imidazole, kupezeka kwa tinidazole kumatha kuchitika, kuwoneka kwa mtanda chifukwa chogwirizana ndi ciprofloxacin kumawonekeranso mu odwala omwe amasiyana ndi mitundu ina ya fluoroquinolone. Chifukwa chake, pamene wodwalayo adazindikira kuti pali zovuta zilizonse zomwe zingachitike ndi mankhwala ofananawo, munthu ayenera kuganizira za zovuta zomwe zingachitike ndi cyfran ST.

Pa mankhwala, ndikofunikira kuwunika chithunzithunzi cha magazi aziphuphu.

Kugwiritsa ntchito kwa Cifran ST ndi mowa kumapangidwa, chifukwa kuphatikiza kwa tinidazole ndi mowa, kukokana kwam'mimba, kusanza, ndi mseru kumatha kuyamba.

Poyerekeza ndi khunyu, mbiri yodwala, matenda a mtima komanso kuwonongeka kwa ubongo, Tsifran ST ikhoza kugwiritsidwa ntchito pazifukwa zaumoyo zokha, zomwe zimagwirizanitsidwa ndi kuwopsa kwa zovuta zamkati zamanjenje.

Kuchita bwino / chitetezo cha kugwiritsa ntchito Tsifran ST pochiza komanso kupewa matenda a anaerobic mwa ana osakwana zaka 12 sizinakhazikitsidwe.

Ngati kutsegula kwambiri kwa nthawi yayitali kukachitika / mutachira, pseudomembranous colitis iyenera kuyikika kunja, komwe kumafunika kuchotsedwa kwa mankhwalawo ndi kupatsidwa chithandizo choyenera.

Pankhani ya kupweteka kwa tendons kapena kuwonetsa kwa zizindikiro zoyambirira za tenosynovitis, kuyang'anira kwa cyfran ST kwathetsedwa.

Kuyanjana kwa mankhwala osokoneza bongo

anticoagulants osadziwika: mphamvu zawo zimatheka, kuti muchepetse magazi, mlingo umachepetsedwa ndi 50%,
Mitsempha: zotsatira zake zimapangidwira, mwina chitukuko cha zochita za disulfiram,
ethionamide: kuphatikiza kosavomerezeka,
phenobarbital: kagayidwe ka tinidazole kwathandizira.

Tinidazole angagwiritsidwe ntchito molumikizana ndi sulfonamides ndi maantibayotiki (erythromycin, aminoglycosides, rifampicin, cephalosporins).

Wopanga

Zosakaniza zogwira ntchito: ciprofloxacin hydrochloride 297.07 mg, wofanana ndi ciprofloxacin 250 mg.

Omwe amathandizira: microcrystalline cellulose 25.04 mg, starch 18.31 mg, magnesium stearate 3.74 mg, oyera talc 2.28 mg, colloidal anhydrous silicon 4.68 mg, sodium starch glycolate 23.88 mg, madzi oyeretsedwa * q.s.

Zithunzi za sheath: Filamu ya Opadray-OY-S58910 yoyera 13.44 mg, yoyeretsedwa talc 1.22 mg, oyeretsa talc q.s., madzi oyeretsedwa.

Zotsatira za pharmacological

Tsifran - yotakata yotakata antibacterial, bactericidal, antibacterial.

Imalepheretsa bakiteriya wa DNA gyrase ndikusokoneza kapangidwe ka bakiteriya, komwe kumayambitsa kufa kwa khungu la bakiteriya.

Mwamsanga odzipereka kuchokera m'mimba thirakiti, pakamwa bioavailability pafupifupi 70%. Pambuyo pa limodzi lokha la 250 ndi 500 mg, kuchuluka kwambiri kwa seramu ndi 1.5 ndi 2.5 2.5g / L, motsatana, ndipo nthawi zambiri kumadutsa MPC90 kwa tizilombo tambiri. Pambuyo iv makonzedwe a 200 mg, ndende ya seramu ndi 3,8 μg / ml. Zogawidwa mofananamo ndipo zimafika pozindikira zochizira zotsekemera zimakhala ndi madzi ambiri. Mlingo wa zomanga mapuloteni ndizochepa (19-40%). Amawachotsa ndi mkodzo, komanso ndulu ndi ndowe.

Matenda amitsempha yam'mimba, chinzonono, chibayo, khungu ndi zofinya minofu, matenda amfupa ndi olowa, matenda amkati, balere, poyizoni wamagazi.

Kuchita

Pogwiritsa ntchito munthawi yomweyo mankhwala a didanosine okhala ndi ciprofloxacin, mphamvu ya ciprofloxacin imachepetsedwa chifukwa cha mapangidwe a maprofloxacin okhala ndi zotayidwa ndi mchere wa magnesium womwe umapezeka mu didanosine.

Kukhazikitsidwa munthawi yomweyo kwa ciprofloxacin ndi theophylline kungayambitse kuchuluka kwa theophylline mu plasma ya magazi chifukwa cha kupikisana kwampikisano pamasamba a cytochrome P450 kumangiriza, komwe kumabweretsa kuwonjezeka kwa theka la moyo wa theophylline ndikuwonjezera pachiwopsezo cha zotsatira zakupha.

Kukhazikitsidwa munthawi yomweyo kwa sucralfate, ma antacid, mankhwala okhala ndi mphamvu yambiri ya buffer (mwachitsanzo, mankhwala othandizira ma antiretroviral), komanso mankhwala okhala ndi aluminium, zinc, iron kapena magnesium ion, angapangitse kuchepa kwa mayamwidwe a ciprofloxacin, kotero ciprofloxacin iyenera kumwedwa mwina maola 22 kale kapena maola 4 mutatha kumwa mankhwalawa.

Kuchepetsa uku sikugwira ntchito maantacid omwe ali m'gulu la H2 receptor blockers.

Kugwiritsa ntchito nthawi yomweyo ciprofloxacin, zinthu zamkaka kapena zakumwa zozikika mtima (mwachitsanzo mkaka, yogati, mandimu a lalanje wokhala ndi calcium) ziyenera kupewedwa, chifukwa kuperewera kwa ciprofloxacin kungachepe. Komabe, calcium, yomwe ndi gawo la zakudya zina, sizikhudza kwambiri mayamwidwe a ciprofloxacin.

Pogwiritsa ntchito kuphatikizana kwa ciprofloxacin ndi omeprazole, kuchepa kwapang'onopang'ono kwa kuchuluka kwa ndende (Cmax) ya magazi m'magazi am'magazi komanso kuchepa kwa malo m'ndende ya nthawi yotsalira (AUC).

Kuphatikizidwa kwa milingo yayikulu kwambiri ya quinolones (gyrase inhibitors) ndi mankhwala ena osapweteka a antiidal (kupatula acetylsalicylic acid) kungayambitse kugwidwa.

Pogwiritsa ntchito munthawi yomweyo ciprofloxacin ndi anticoagulants (kuphatikizapo warfarin), nthawi yotuluka magazi imachulukana.

Pogwiritsa ntchito munthawi yomweyo ciprofloxacin ndi cyclosporine, mphamvu ya nephrotoxic yotsiriza imalimbikitsidwa. Ndi mankhwala omwewo munthawi yomweyo ndi ciprofloxacin ndi cyclosporine, kuwonjezeka kwakanthawi kwa plasma creatinine ndende kunawonedwa. Zikatero, ndikofunikira kudziwa kuchuluka kwa creatinine m'magazi kawiri pa sabata.

Nthawi zina, kugwiritsa ntchito pamodzi kwa chiprofloxacin ndi glibenclamide kumatha kukulitsa mphamvu ya glibenclamide (hypoglycemia).

Kugwirizana kwa uricosuric mankhwala, kuphatikizapo phenenecid, kumachepetsa kuchepetsa mphamvu ya improfloxacin ndi impso (mpaka 59%) ndikuchulukitsa kuchuluka kwa ciprofloxacin m'madzi am'magazi.

Ndi munthawi yomweyo makonzedwe a ciprofloxacin, ma tubular transport (aimpso metabolism) a methotrexate amatha kuchepa, omwe atha kukhala limodzi ndi kuchuluka kwa methotrexate m'madzi a m'magazi. Pankhaniyi, mwayi wazotsatira za methotrexate zitha kuchuluka. Pankhaniyi, odwala omwe amalandila mankhwala ophatikizana ndi methotrexate ndi ciprofloxacin ayenera kuyang'aniridwa bwino.

Metoclopramide imathandizira kuyamwa kwa ciprofloxacin, kuchepetsa nthawi yofunikira kuti ikwaniritse ndende yake yambiri m'madzi a m'magazi. Pankhaniyi, bioavailability wa ciprofloxacin sasintha.

Zotsatira zakufukufuku wazachipatala wokhudzana ndi odzipereka wathanzi omwe amagwiritsidwa ntchito munthawi yomweyo kugwiritsa ntchito ciprofloxacin ndi tizanidine, kuwonjezeka kwa kuchuluka kwa tizanidine m'madzi a m'magazi kunawululidwa: kuwonjezeka kwa Cmax nthawi 7 (kuyambira nthawi 4 mpaka 21), kuwonjezeka kwa AUC nthawi 10 (kuyambira nthawi 6 mpaka 24). Ndi kuwonjezeka kwa ndende ya tizanidine mu seramu yamagazi, hypotensive ndi kusinthasintha zimayenderana. Chifukwa chake, kugwiritsa ntchito munthawi yomweyo ciprofloxacin ndi tizanidine ndizotsutsana.

Ciprofloxacin itha kugwiritsidwa ntchito limodzi ndi maantibayotiki ena.Monga tawonetsera mu maphunziro a in vitro, kugwiritsa ntchito mankhwala ophatikizira mankhwala a chiprofloxacin ndi β-lactam, komanso aminoglycosides, kumayendetsedwa ndiwowonjezera komanso wopanda chidwi, kuwonjezeka kwa zotsatira zamankhwala onsewa kunali kocheperako, komanso sikowonjezera kufooka.

Momwe mungatenge, njira ya makonzedwe ndi kumwa

Mkati, pamimba yopanda kanthu, popanda kutafuna, ndimadzi pang'ono. Zitha kumwedwa mosaganizira zakudya. Ngati mankhwalawa agwiritsidwa ntchito pamimba yopanda kanthu, zinthu zomwe zimayamba kugwira ntchito zimatengedwa mwachangu. Pankhaniyi, mapiritsi sayenera kutsukidwa ndi zinthu zamkaka kapena zokhala ndi calcium (mwachitsanzo, mkaka, yogati, timadziti tokhala ndi calcium yambiri). Kashiamu wopezeka muzakudya wamba sizikhudza mayamwidwe a ciprofloxacin.

Mlingo wa ciprofloxacin zimatengera kuuma kwa matendawa, mtundu wa matenda, mkhalidwe wamthupi, zaka, kulemera ndi impso ntchito ya wodwalayo. Mlingo Walimbikitsa:

Matenda a m'munsi kupuma thirakiti (pachimake ndi aakulu (pachimake siteji) bronchitis, chibayo, bronchiectasis, matenda a cystic fibrosis) wofatsa mwamphamvu - 500 mg 2 kawiri pa tsiku, mu milandu - 750 mg 2 kawiri pa tsiku. Njira ya mankhwala ndi masiku 7-14.

Matenda a ziwalo za LOP (atitis media, pachimake sinusitis) - 500 mg kawiri pa tsiku, njira ya mankhwalawa ndi masiku 10.

Matenda a mafupa ndi mafupa (osteomyelitis, septic nyamakazi) - kufatsa kwambiri - 500 mg 2 kawiri pa tsiku, mu milandu - 750 mg 2 zina. Njira ya chithandizo mpaka milungu isanu ndi umodzi.

Matenda a pakhungu ndi minyewa yofewa (zilonda zopatsirana, mabala, zilonda zam'mimba, mapiritsi a phlegmon) modekha - 500 mg kawiri pa tsiku, m'malo ovuta - 750 mg kawiri pa tsiku. Njira ya mankhwala ndi masiku 7-14.

Campylobacteriosis, shigellosis, matenda am'mimba "oyenda" - 500 mg kawiri pa tsiku, maphunzirowa ndi masiku 5-7.

Typhoid fever - 500 mg kawiri pa tsiku kwa masiku 10.

Matenda ophatikizika a m'mimba (osakanikirana ndi metronidazole) - 500 mg kawiri pa tsiku kwa masiku 7-14.

Matenda a impso ndi kwamikodzo thirakiti (cystitis, pyelonephritis) - 250 mg, zovuta - 500 mg 2 kawiri pa tsiku. Njira ya mankhwala ndi masiku 7-14. Cystitis yosavomerezeka mu akazi - 250 mg kawiri pa tsiku kwa masiku atatu.

Gonorrhea wosavomerezeka - 250-500 mg kamodzi.

Bakiteriya matenda a prostatitis - 500 mg 2 kawiri pa tsiku, mankhwala Inde - masiku 28.

Matenda ena (onani gawo "Zizindikiro") - 500 mg kawiri pa tsiku. Septicemia, peritonitis (makamaka ndi matenda a Pseudomonas, Staphylococcus kapena Streptococcus) - 750 mg 2 kawiri pa tsiku.

Kupewa ndi kuchiza kwa anthrax ya pulmonary - 500 mg 2 pa tsiku kwa masiku 60.

Pochiza odwala okalamba, mulingo wochepetsetsa kwambiri wa chiprofloxacin uyenera kugwiritsidwa ntchito, kutengera kuwonongeka kwa matendawa ndi kuvomerezeka kwa creatinine (mwachitsanzo, ndi chilolezo cha creatinine cha 30-50 ml / min, mlingo woyenera wa ciprofloxacin ndi 250-500 mg maola 12 aliwonse.

Zochizira mavuto am'mapapo am'mimba cystic fibrosis chifukwa cha Pseudomonas aeruginosa ana a zaka 5 mpaka 17, 20 mg / kg thupi 2 kawiri / tsiku zotchulidwa pakamwa. (mlingo waukulu wa 1500 mg). Kutalika kwa chithandizo ndi masiku 10-14.

Kwa kupewa ndi kuchiza kwa anthrax ya m'mapapo am'mimba, 15 mg / kg thupi kawiri / tsiku limalembedwa pakamwa (mlingo umodzi woyenera suyenera kupitirira - 500 mg ndi mlingo wa tsiku ndi tsiku - 1000 mg).

Kumwa mankhwalawa kuyenera kuyamba mukangotenga kachilomboka kapena kuti mwatsimikizira kachilomboka.

Kutalika konse kwa ciprofloxacin m'mapapo a mphumu ndi masiku 60.

Malangizo apadera

Zinapezeka kuti ciprofloxacin, monga mankhwala ena amakalasi iyi, amachititsa arthropathy ya mafupa akulu a nyama. Mukafufuza za chitetezo chomwe chikugwiritsidwa ntchito ngati mwana wazaka zosaposa 18 zakubadwa, ambiri omwe ali ndi pulmonary cystic fibrosis, palibe kulumikizana pakati pa kuwonongeka kwa cartilage kapena mafupa omwe amamwa mankhwalawa. mapapo (mwa ana a zaka zapakati pa 5 mpaka 17) ogwilizana ndi Pseudomonas aeruginosa komanso pochiza komanso kupewa matenda a m'mapapo a m'mimba Bacillus anthracis).

Pazakudya zapathengo za odwala omwe ali ndi chibayo chifukwa cha mabakiteriya amtundu wa chibayo, ciprofloxacin sayenera kugwiritsidwa ntchito ngati mankhwala oyamba.

Nthawi zina, mavuto omwe amakhudzana ndi dongosolo lamanjenje amatha kuchitika atagwiritsidwa ntchito koyamba kwa mankhwalawa. Nthawi zina, psychosis imatha kudziwonetsa yakufuna kudzipha. Muzochitika izi, kugwiritsa ntchito ciprofloxacin kuyenera kuyimitsidwa nthawi yomweyo.

Odwala omwe ali ndi mbiri ya kukomoka, mbiri ya kukomoka, matenda am'mitsempha, komanso kuwonongeka kwa ubongo chifukwa cha chiwopsezo chakusokonezeka kwapakati pa dongosolo lamanjenje lamkati, ciprofloxacin iyenera kuyikidwa pokhapokha "zofunikira" mankhwala.

Ngati kutsegula m'mimba kwambiri kwakanthawi kapena kuthandizira pakumupeza mankhwala a chiprofloxacin, kuwunika kwa pseudomembranous colitis kuyenera kusiyidwa kunja, komwe kumafunika kuchotsedwa kwa mankhwalawo ndi kuperekedwa kwa chithandizo choyenera.

Kugwiritsa ntchito mankhwala omwe amachepetsa matumbo athu kumatsutsana. Odwala, makamaka omwe ali ndi matenda a chiwindi, amatha kukhala ndi cholendatic jaundice, komanso kuwonjezeka kwakanthawi kwa ntchito ya "chiwindi" transaminases ndi alkaline phosphatase.

Kuthana ndi njira yoyenera ya mankhwalawa ndikofunikira popereka mankhwala kwa odwala omwe ali ndi impso ndi kwa chiwindi.

Nthawi zina, mutatha kutenga koyamba muyezo wa ciprofloxacin, thupi limakumana ndi vuto losayembekezereka. Kulandila kwa ciprofloxacin mu milandu iyi kuyenera kuyimitsidwa nthawi yomweyo ndipo chithandizo choyenera chikuyenera kuchitika.

Okalamba odwala omwe amathandizidwa ndi glucocorticosteroids, pakhoza kukhala kupasuka kwa Achilles tendon.

Ngati pali zowawa m'misempha kapena ngati zizindikiro zoyambirira za tendonitis zikuwoneka, mankhwalawa ayenera kusiyidwa chifukwa chakuti milandu yokhayokha yotupa komanso kupasuka kwa tendons munthawi ya chithandizo ndi fluoroquinolones amafotokozedwa.

Pa chithandizo cha ciprofloxacin, kulumikizana ndi dzuwa mwachindunji kuyenera kupewedwa, chifukwa mawonekedwe a photosensitization amatha kupezeka ndi ciprofloxacin. Kuchiza kuyenera kusiyidwa ngati chizindikiro cha zithunzi zapezeka (mwachitsanzo, kusintha pakhungu kofanana ndi kutentha kwa dzuwa).

Ciprofloxacin amadziwika kuti ndi cholepheretsa zolimbitsa thupi za CYP1A2 isoenzyme.

Chenjezo liyenera kugwiritsidwa ntchito mukamagwiritsa ntchito ciprofloxacin ndi mankhwala omwe amapangidwa ndi isoenzyme iyi, monga theophylline, methylxanthine, caffeine, chifukwa kuwonjezeka kwa kuchuluka kwa mankhwalawa mu seramu yamagazi kumatha kuyambitsa mavuto.

Pofuna kupewa kukonzekera kwa crystalluria, sizivomerezeka kupitirira mlingo womwe umalimbikitsidwa tsiku ndi tsiku, kuthira madzi okwanira (malinga ndi diuresis yachilendo) ndikusamalanso mkodzo wa acid acid ndikofunikira.

Mu matenda amtundu, omwe mwina amayambitsidwa ndi Neisseria gonorrhoeae tizilombo toyambitsa matenda a fluoroquinolones, chidziwitso cha m'deralo chokhudza kukana kwa profrofloxacin chikuyenera kuganiziridwa ndipo kukhudzika kwa pathogen kuyenera kutsimikiziridwa mu labotale teCmax.

Mphamvu pa kuyendetsa magalimoto, machitidwe:

Odwala omwe amatenga ciprofloxacin ayenera kusamala poyendetsa galimoto ndikuchita zina zomwe zingakhale zowopsa zomwe zimafuna chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.

Mlingo ndi makonzedwe

Cifran mwa njira yothetsera kulowetsedwa amalembera milandu pomwe wodwala sangathe kumwa mapiritsi. Pambuyo pakuwongolera mkhalidwe wodwala, iyenera kusamutsidwa ku mawonekedwe a piritsi.

Mapiritsi amatengedwa pakamwa ponse, osambitsidwa ndi madzi okwanira. N`zotheka kugwiritsa ntchito mankhwalawa mosasamala kanthu za chakudya, koma mukamwetsa pamimba yopanda kanthu, chinthu chomwe chimagwira mwachangu, ndipo simuyenera kumwa mankhwalawa ndi mkaka kapena zakumwa zomangidwa ndi calcium. Kashiamu yokhala ndi zakudya sizikhudzana ndi mayamwa.

Malangizo a mtundu wa mankhwala:

matenda am'munsi opatsirana a kupuma: 500 mg 2 kawiri pa tsiku (kwaofatsa pang'ono), 750 mg 2 pa tsiku (kwa matenda oopsa), kwa masiku 7-14,
Matenda a ENT: 500 mg kawiri pa tsiku, kwa masiku 10,
matenda a mafupa ndi mafupa: 500 mg kawiri pa tsiku (kufatsa pang'ono matenda), 750 mg 2 kawiri pa tsiku (kwa matenda oopsa), kwa masabata 4-6,
matenda a pakhungu ndi minyewa yofewa: 500 mg kawiri pa tsiku (kufatsa pang'ono matenda), 750 mg kawiri pa tsiku (matenda akulu) kwa masiku 7-14,
campylobacteriosis, shigellosis, maulendo am'mimba: 500 mg 2 kawiri pa tsiku kwa masiku 5-7,
typhoid fever: 500 mg kawiri pa tsiku, kwa masiku 10,
zovuta zamkati pamatumbo: 500 mg kawiri pa tsiku kwa masiku 7-14,
matenda a impso ndi kwamkodzo thirakiti: 250 mg kawiri pa tsiku (matenda osavuta), 500 mg kawiri pa tsiku (zovuta) kwa masiku 7-14, cystitis yovuta kwa azimayi - 250 mg kawiri pa tsiku kwa masiku atatu ,
gonorrhea (wopepuka): 250-500 mg amatengedwa kamodzi,
bakiteriya matenda a prostatitis: 500 mg 2 kawiri pa tsiku kwa masiku 28,
sepsis, peritonitis: 750 mg 2 pa tsiku,
anthrax ya pulmonary (kupewa ndi kuchiza): 500 mg 2 kawiri pa tsiku kwa masiku 60.

Kwa matenda ena, mlingo womwe umalimbikitsa ndi 500 mg kawiri pa tsiku.

Odwala okalamba ayenera kugwiritsa ntchito Mlingo wochepetsedwa wa mankhwalawa (mlingo umadalira kukula kwa matendawo ndi chilolezo cha creatinine).

Kugwiritsa ntchito kwa Cyfran mu ana:

Mavuto oyambitsidwa ndi Pseudomonas aeruginosa, motsutsana ndi pulmonary cystic fibrosis mwa ana a zaka 5 mpaka 17: 20 mg / kg kawiri pa tsiku, mlingo waukulu - 1500 mg, kwa masiku 10 mpaka 14,
pulmonary anthrax (prophylaxis ndi chithandizo): 15 mg / kg kawiri pa tsiku, mlingo umodzi wambiri ndi 500 mg, tsiku lililonse mlingo ndi 1000 mg, kwa masiku 60 (mankhwalawa amayenera kuyamba mwachangu atatha kukayikira kapena kutsimikizika).

Odwala ndi mkhutu aimpso ntchito:

ndi creatinine chilolezo (CC) cha 31-60 ml / min, mlingo wokwanira tsiku lililonse wa mankhwala ndi 1000 mg (250-500 mg maola 12 aliwonse),
ndi CC zosakwana 30 ml / min, muyeso wokwanira tsiku lililonse wa mankhwalawa ndi 500 mg (nthawi 250-500 mumaola 18).

Odwala hemodialysis ayenera kumwa mankhwala pambuyo njirayi.

Panthawi ya chiwindi kuwonongeka ntchito, kusintha kwa cyfran sikofunikira.

Mankhwalawa amayenera kupitilizidwa kwa masiku osachepera atatu atatha zizindikiro za matendawa.

Malangizo okhudza nthawi ya chithandizo ndi Cifran:

Gonorrhea (Wosavuta): 1 tsiku,
chitetezo chokwanira: mu nthawi yonse ya neutropenia,
osteomyelitis: nthawi yayitali ya mankhwalawa ndi masiku 60,
matenda ena: masabata 1-2,
Matenda a streptococcal: kutalika kochepa kwambiri kwamankhwala ndi masiku 10.

Kulowetsedwa njira

Pofuna kupewa zotsatira zosavomerezeka pamalowa kulowetsedwa, Cifran akulimbikitsidwa kuti ajowedwe m'mitsempha yayikulu kwa mphindi zosachepera 60.

Mlingowo umaperekedwa molingana ndi kuopsa kwa matendawa, mtundu wake, momwe wodwalayo alili, zaka zake komanso kulemera kwa thupi, komanso ntchito ya impso.

Mlingo woyenera:

matenda opatsirana thirakiti: 400 mg katatu patsiku, kutengera kuopsa kwa matendawa.
matenda a genitourinary system: 200-400 mg 2 kawiri pa tsiku (pachimake, osavuta, mwachitsanzo, chinzonono, 400 mg katatu patsiku (zovuta, monga prostatitis, adnexitis), 400 mg katatu patsiku (wowopsa komanso makamaka matenda oopsa, monga sepsis, peritonitis, matenda a mafupa ndi mafupa),
anthrax ya m'mapapo mwanga: 400 mg kawiri pa tsiku (kwa achikulire), 10 mg / kg kawiri pa tsiku (kwa ana), mlingo umodzi wambiri - 400 mg, tsiku lililonse - 800 mg, kwa masiku 60 (kuyamba mankhwalawa posachedwa pambuyo pa kukayikiridwa kapena kutsimikiziridwa kachilombo),
matenda ena: 400 mg 2 kawiri pa tsiku, ngati mukudwala kwambiri - katatu patsiku, kwa masabata 1-2, ngati ndi kotheka, kuwonjezeka kwa nthawi yonse ya chithandizo ndikotheka.

Odwala ndi mkhutu aimpso ntchito:

ndi CC 30-60 ml / min, muyeso wokwanira tsiku lililonse wa mankhwalawa ndi 800 mg,
ndi CC zosakwana 30 ml / min, muyeso wokwanira tsiku lililonse wa mankhwalawa ndi 400 mg.

Mankhwalawa amayenera kupitilizidwa kwa masiku osachepera atatu atatha zizindikiro za matendawa.

Malangizo okhudza nthawi ya chithandizo ndi Cifran:

Gonorrhea (Wosavuta): 1 tsiku,
chitetezo chokwanira: mu nthawi yonse ya neutropenia,
osteomyelitis: nthawi yayitali ya mankhwalawa ndi masiku 60,
matenda ena: masabata 1-2,
matenda a streptococcal, matenda oyambitsidwa ndi chlamydia: nthawi yayitali ya mankhwala ndi masiku 10.