Momwe mungatenge metformin 850 kuti muchepetse kunenepa

Metformin ndi chinthu chomwe chimakhala ndi biguanides. Metformin ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda ashuga.

Kuchita kwa mankhwalawa kumachitika chifukwa chakuti imatha kulepheretsa kayendedwe ka gluconeogenesis m'maselo a chiwindi, imachepetsa kuthamanga kwa glucose kuchokera m'matumbo a lumen ndikuthandizira njira zophatikizira magwiritsidwe ake a shuga.

Kuphatikiza apo, mapiritsi a Metformin 850 mg amawonjezera kukhudzika kwa insulin m'maselo a insulin omwe amadalira thupi.

Kugwiritsa ntchito mankhwalawa kulibe phindu lililonse pakapangidwe ka insulin mu kapamba, sikuti kumayambitsa chitukuko cha dziko la hypoglycemia. Kumwa mankhwala kumatha kuchepetsa kuchuluka kwa triglycerides ndi lipoprotein m'magazi.

The zikuchokera mankhwala ndi mankhwala

Mankhwala tikulephera kukula kwa polyperation wa yosalala minofu zinthu makoma a mtima dongosolo. Zotsatira zabwino za mankhwala pokhudzana ndi mtima ndi mtima zimawululidwa ndikulepheretsa kukula kwa matenda a shuga.

Chithandizo cha matenda ashuga ndi Metformin chitha kuperekedwa ndi dokotala mutatha kupenda wodwalayo mozama. Kutalika kwa mankhwalawa komanso mlingo wa mankhwalawa amagwiritsidwa ntchito kutsimikiza mawonekedwe onse amomwe matendawa ali mthupi la wodwalayo.

Chithandizo chogwira mankhwalawa ndi Metformin hydrochloride. Piritsi limodzi lili ndi 850 mg yogwira mankhwala. Kuphatikiza pazomwe zimapangidwira, kuphatikiza kwa mankhwalawa kumaphatikizapo mankhwala othandizira.

Mankhwala omwe amapanga mankhwalawa ndi awa:

calcium phosphate dibasic,
wowuma chimanga
lactose
povidone
sodium benzoate,
talcum ufa
magnesium wakuba,
sodium wowuma glycolate,
titanium dioxide
hydroxypropyl methylcellulose,
cellulose
propylene glycol
polyethylene glycol.

Kutenga Metformin sikukhudzanso kuchuluka kwa mahomoni m'thupi la munthu, koma kumathandizira kusintha kwa mankhwala ake, omwe amachitika chifukwa chakuchepa kwa chiwerengero pakati pa insulin ndi mfulu, kuchuluka kwa thupi la munthu pakati pa insulin ndi proinsulin. Chimodzi mwazinthu zofunika kwambiri pakupanga zochita za mankhwalawa ndicho kukoka kwa glucose pogwiritsa ntchito minofu ya minofu.

Chithandizo chogwira ntchito chimathandizira kufalikira kwa magazi mu minyewa ya chiwindi ndikuthandizira kuthamanga kwa glucose mu glycogen. Kugwiritsa ntchito Metformin 850 mg kumawongolera michere ya magazi. Izi ndichifukwa chokakamira minofu ya plasminogen activator inhibitor.

Kulowetsedwa kwa chinthu chogwira ntchito kumachitika kuchokera ku lumen ya m'mimba ndipo ndi chizindikiro chomwe chimachokera ku 48 mpaka 52%. Hafu ya moyo wa mankhwala othandizira ali pafupifupi maola 6.5.

Thupi lomwe limagwira limachotsedwa m'thupi la munthu momwe limapangidwira. Gawo lothandizirali siligwirizana ndi ma protein a plasma a magazi. Kudzikundikira kwa mankhwalawa kumachitika ndi tiziwalo tating'ono, minofu minofu, impso ndi chiwindi.

Kuchoka m'thupi ndi impso pokonza mkodzo.

Zizindikiro ndi contraindication kugwiritsa ntchito mankhwala

Sonyezani shuga yanu kapena sankhani jenda pamayendedwe Akusaka Osapezeka Kusaka sakupeza Kusaka sikupezeka

Zizindikiro zazikulu zogwiritsidwa ntchito ndi izi:

kukhalapo kwa matenda a shuga a mtundu 2 popanda kutanthauza ketoacidosis,
kukhalapo kwa matenda ashuga osagwira ntchito kuchokera ku zakudya,
mankhwalawa a mtundu 2 a shuga limodzi ndi insulin, makamaka ndi kunenepa kwambiri, komwe kumayendetsedwa ndi kuwoneka kwachiwiri kwa insulin.

Chachikulu contraindication kugwiritsa ntchito mankhwala mankhwalawa mtundu 2 matenda ashuga ndi awa:

kukula kwa matenda a shuga a ketoacidosis, matenda a shuga kapena chikomokere,
kuphwanya impso ntchito,
zikamera ndi kupita patsogolo kwa thupi la wodwalayo matenda owopsa omwe ali ndi chiwopsezo cha impso - kusowa kwamadzi, kutentha thupi, matenda obwera ndi impso, kukulira matenda a bronchopulmonary,
kukula kwa matenda oopsa komanso osachiritsika omwe angayambitse kupitilira kwa minofu hypoxia,
kuchitira opaleshoni yayikulu mthupi ndi wodwala kulandira kuvulala kwambiri m'thupi,
kupezeka ndi kuwonjezereka kwa zovuta pakugwira ntchito kwa chiwindi,
Wodwala amakhala ndi chidakwa choperewera kapena chakumwa chakumwa choopsa,
kukula kwa lactic acidosis mthupi,
kufunikira kwa zakudya zamafuta ochepa,
nthawi ya bere,
nthawi yonyamula
wodwalayo ali ndi hypersensitivity pamagawo a mankhwala.

Malangizo ogwiritsira ntchito mankhwalawa

Kuti mudziwe momwe mungamwe mankhwalawo molondola, muyenera kufunsa dokotala. Wodwala ayenera kuphunzira malangizo ogwiritsira ntchito Metformin.

Mlingo wa mankhwalawa umakhazikitsidwa ndi endocrinologist wokhazikika. Dokotala ndi amene amawerengera kuti wodwala aliyense payekhapayekha, poganizira zotsatira zomwe amapezeka poyeserera thupi ndikuzindikira momwe thupi la wodwalayo lilili. Mlingo wa mankhwala omwe wodwala amayenera kumwa umadalira kuchuluka kwa shuga m'magazi am'magazi.

Kuti muthe kutenga Metformin molondola, mlingo woyambirira uyenera kukhala kuchokera 500 mpaka 1000 mg patsiku, ndiwo mapiritsi 1-2. Pambuyo masiku 10 akuvomerezedwa, malinga ndi lingaliro la endocrinologist kuyang'ana wodwalayo, kuwonjezeranso kwakukulu kwa mankhwalawa ndikotheka ngati izi zimafunidwa ndi kuchuluka kwa shuga m'thupi la wodwalayo.

Malangizo ogwiritsira ntchito akutsimikiza kuti mugwiritse ntchito 1500-2000 mg ya mankhwalawa ngati mlingo wokonzera, womwe ndi mapiritsi 3-4, ndipo mlingo waukulu wololedwa kumwa ndi 3000 mg patsiku.

Pankhani ya chithandizo cha matenda a shuga 2 a odwala okalamba, mlingo womwe mankhwalawa amagwiritsidwa ntchito kuchipatala sayenera kupitirira 1 mapiritsi 2 kapena 2 patsiku.

Mapiritsi amayenera kumwedwa pakamwa popanda kutafuna nthawi yakudya kapena itatha. Mankhwala ayenera kumwedwa ndi madzi ochepa. Pofuna kupewa kukula kwa zoyipa mthupi, mulingo wa tsiku ndi tsiku umalimbikitsidwa kuti ugaledwe mu Mlingo wa 2-3.

Popeza mukamamwa mankhwalawa, pamakhala kuthekera kwakukulu kokuluka kwa lactic acidosis, mlingo womwe umagwiritsidwa ntchito pochiza matenda amisempha 2 amachepetsa ngati wodwala ali ndi vuto lalikulu la metabolic.

Pankhani ya munthawi yomweyo makonzedwe ndi insulin muyezo wa osaposa 40 magawo patsiku, mulingo wa mankhwalawa unasinthidwa. Mankhwala omwe amafunikira tsiku ndi tsiku insulin yoposa 40 magawo patsiku, muyezo wa mankhwala ayenera kumwedwa mosamala kwambiri. Kusankha kwa mankhwala kuyenera kuchitidwa mu chipatala moyang'aniridwa ndi adokotala.

Zotsatira zoyipa za mankhwala m'thupi

Ndi kugwiritsa ntchito mankhwalawa kwakanthawi, zotheka kuchitika mthupi la mavuto omwe amabwera chifukwa cha kuyamwa kwa vitamini B12.

Ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, muyenera kuwunika chidwi chachikulu kuti muwone momwe minyewa ya chiwindi imagwira ntchito komanso impso.

Mukamagwiritsa ntchito mankhwalawa zotsatirazi zingachitike:

Kuchokera pakugwira ntchito kwa m'mimba, matenda osokoneza bongo amatha, kuwonekera mawonekedwe amtundu wa mseru, kusanza, kupweteka pamimba, kuchepa kapena kusowa kwa chakudya, mawonekedwe amtundu wamkamwa wamkamwa.
Kuchokera pakhungu pali kuthekera kwa matupi amtundu wa khungu.
Dongosolo la endocrine limatha kuyankha kugwiritsa ntchito mankhwalawa popanga machitidwe a hypoglycemic. Nthawi zambiri, zotere zimachitika chifukwa cha kuchuluka kwa mankhwalawa.
Kumbali ya njira ya kagayidwe kachakudya nthawi zina, mukamamwa mankhwala osakwanira, kukula kwa lactic acidosis mthupi kungachitike. Izi zikachitika, kusiya mankhwala kumafunika.
Njira yozungulira imatha kuyankha mankhwalawa mwa kupangidwa kwa magazi m'thupi.

Chifukwa cha ngozi yayikulu mthupi, kugwiritsa ntchito metformin pamaso pa kulephera kwa impso kumayenera kuyimitsidwa kapena kuyenera kuyang'aniridwa ndi achipatala komanso muyezo wochepa.

Ambiri endocrinologists pankhaniyi amalimbikitsa kuyimitsa mankhwalawo kwathunthu, ndikuyamwa pamtengo wochepetsedwa kwambiri, chifukwa kuyang'anira shuga ndizofunikira.

Malangizo apadera ogwiritsira ntchito Metformin

Mukakonzekera kukhala ndi pakati kapena pakachitika, mankhwalawo ayenera kusiyidwa. Ngati muli ndi pakati, kugwiritsa ntchito mankhwalawa panthawi ya gestation kumachotsedwa ndi insulin.

Popeza palibe chidziwitso pakulowerera kwazomwe zimapangidwira mankhwala ndikuphatikizika pakukonzekera mkaka, mukamagwiritsa ntchito yoyamwitsa, kugwiritsa ntchito mankhwalawa kuyenera kuyimitsidwa. Ngati pakufunika kugwiritsa ntchito Metformin panthawi yotsekemera, yoyamwitsa iyenera kuyimitsidwa.

Kugwiritsa ntchito mankhwalawa ndizoletsedwa kwa ana ndi achinyamata osakwana zaka 18.

Madokotala salimbikitsa kugwiritsa ntchito mankhwalawa mankhwalawa odwala matenda ashuga okalamba, omwe zaka zawo zafika zaka 60 ndikugwira ntchito yolemetsa yokhudzana ndi kuwonjezeka kwa thupi. Malangizowa akuchitika chifukwa chakuti odwala oterewa amatha kukulitsa lactic acidosis mthupi.

Pankhani yotenga Metformin, imatha kuphatikizidwa ndi othandizira ochokera ku sulfonylurea. Ndi mankhwala ophatikizika oterowo, kuwunikira mosamala kwambiri momwe chizolo chamagulu a shuga chilili.

Ndi zoletsedwa kumwa mowa ndi mankhwala omwe amakhala ndi ethanol panthawi yomwe amamwa mankhwalawa. Kutenga Metformin nthawi yomweyo ndi mowa kumatha kuyambitsa lactic acidosis mwa wodwala matenda a shuga.

Mtengo wa Metformin, mawonekedwe ake ndi kuwunika kwa wodwala pakugwiritsa ntchito mankhwalawa

Mankhwala otsatirawa ndi fanizo la Metformin:

Bagomet,
Glycon
Glyminfor,
Glyformin
Chikwanje,
Glucophage Long,
Langerine
Methadiene
Metospanin
Metfogamm 500, 850, 1000
Metformin
Metformin Richter,
Metformin Teva,
Metformin hydrochloride,
Nova Met
NovoFormin,
Siofor 1000,
Siofor 500,
Siofor 850,
Sofamet
Fomu,
Forin Pliva.

Ndemanga pakugwiritsa ntchito mankhwalawa ndi odwala pochiza matenda osokoneza bongo akuwonetsa kuti mankhwalawa amathandizira thupi, omwe amakupatsani mwayi wolamulira kuchuluka kwa shuga m'thupi.

Pali ndemanga zambiri zokhudzana ndi mankhwalawa zomwe zimawonetsa kusintha kwamphamvu m'thupi mukamamwa Metformin kapena mawonekedwe ake ndikuwoneka kuti ali ndi mphamvu pakuthandizira odwala matenda ashuga.

Nthawi zambiri, odwala omwe ali ndi matenda a shuga komanso kunenepa kwambiri amawonetsa m'malingaliro awo kuti kugwiritsa ntchito Metformin pantchito yothira mankhwala kumachepetsa kwambiri thupi.

Mtengo wa mankhwalawa m'masitolo am'dziko muno zimatengera dera komanso ma CD ake.

Mtengo wa mankhwalawa Metformin Teva 850 mg mdziko muno ndi avareji ma ruble 100 pa paketi iliyonse okhala ndi mapiritsi 30.

Mankhwala ngati Metformin Canon 1000 mg ali ndi mtengo wokwanira m'dziko la ma ruble 270 pa paketi iliyonse, omwe ali ndi mapiritsi 60.

Mtengo wa mankhwalawa umadalira kuchuluka kwa mapiritsi omwe ali mumtengowo. Pogula mankhwalawa, muyenera kukumbukira kuti tchuthi chake chimachitika pokhapokha ngati mwalandira ndi dokotala.

Mu kanema munkhaniyi, Dr. Myasnikov amalankhula za mfundo zomwe Metformin angachite pa matenda ashuga.

Sonyezani shuga yanu kapena sankhani jenda pamayendedwe Akusaka Osapezeka Kusaka sakupeza Kusaka sikupezeka

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, salicylates, ma inhibitors a MAO, oxytetracycline, zoletsa ACE, ndi clofibrate, cyclophosphamide, hypoglycemic zotsatira za metformin zimatha kupititsidwa patsogolo.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, njira yolerera ya mahomoni pakugwiritsira ntchito pakamwa, danazol, epinephrine, glucagon, mahomoni a chithokomiro, zotuluka za phenothiazine, zotupa za thiazide, zotumphukira za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Odwala omwe amalandila metformin, kugwiritsidwa ntchito kwa ayodini okhala ndi zotsutsana poyerekeza ndi mayeso (kuphatikizapo intravenous urography, intravenous cholangiography, angiography, CT) kumawonjezera chiopsezo cha kusokonekera kwa impso ndi lactic acidosis. Izi kuphatikiza ndi zotsutsana.

Ma agonist osokoneza bongo a beta2-adrenergic amawonjezera kuchuluka kwa shuga m'magazi chifukwa cha kukondoweza kwa β2-adrenergic receptors. Poterepa, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi. Ngati ndi kotheka, tikulimbikitsidwa kupereka insulin.

Kugwiritsa ntchito cimetidine mozungulira kungakulitse chiopsezo cha lactic acidosis.

Kugwiritsa ntchito munthawi yomweyo mankhwala a "loop" okodzetsa kungayambitse kukula kwa lactic acidosis chifukwa chakulephera kugwira ntchito kwaimpso.

Yofanana makonzedwe ndi Mowa kumapangitsa ngozi lactic acidosis.

Nifedipine imawonjezera mayamwidwe ndi Cmax wa metformin.

Mankhwala a Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim ndi vancomycin) omwe amatulutsidwa mu renal tubules akupikisana ndi metformin yama kachitidwe ka mayendedwe a tubular ndipo amatha kutsogolera Cmax yake.

Metformin yochepetsa kulemera: malamulo ogwiritsira ntchito, mlingo, mtengo, analogi ndi ndemanga

- siyani kunenepa! Mutha kuchepetsa thupi popanda kuchita khama lalikulu.

•Kuchotsa mafuta osagwiritsa ntchito m'mimba ndi m'mbali•Kuchotsa m'thupi "mafuta mkati" owopsa•Amachepetsa mafuta osunthika•Amachotsa poizoni, amatsuka thupi

Metformin (kapena Glucophage mwanjira ina) amatengedwa ndi anthu atatha zaka 20 zakubadwa ndi mtundu wachiwiri wa matenda ashuga, ndipo amatsitsa cholesterol bwino, komabe, ngati insulin imapangidwa m'thupi.

Mukamamwa mankhwalawa, kuchepa thupi kumachitika mofulumira, komwe sikubwerera. Njira zake mthupi ndizosavuta, zimatchinga mafuta onse obwera ndipo sizimalola kuti zisonkhane "m'masitolo" amthupi, mphamvu zowonjezera zaumunthu zimayamba kutha. Chifukwa chake, mitundu yambiri, othamanga komanso anthu omwe akufuna kuti achepetse kulemera kwakanthawi, amatenga Metformin.

Zochita pa thupi

Mankhwalawa amachepetsa kupanga insulin mthupi, kuyamwa kwa mafuta am'mimba m'matumbo am'mimba, kumawonjezera kukhathamiritsa kwa glucose kudzera mu minofu ya minyewa, imathandizira njira zowonjezera zamankhwala amafuta acid komanso metabolism. Zochita zonsezi pa thupi zimayambitsa kuchepa komanso kukula kwa kulemera.

Ubwino waukulu wotenga Metformin ndikuti:

amachepetsa chilakolako champhamvu,
amachepetsa kulakalaka maswiti,
akamamwa moyenera, samayambitsa mavuto,
Amachepetsa ndikusunga shuga wamagazi popanda kutsata insulini,
amachepetsa cholesterol yoyipa mthupi.

Koma chachikulu ndichakuti kulemera kwakatayika mukamamwa mankhwalawo sikudzabwekanso, ngati munthu sakuzunza, monga kale, kuchuluka kwambiri pakudya komanso moyo wongokhala.

Zoyipa zomwe zimagwiritsidwa ntchito pafupipafupi ndi mankhwalawa ndizovuta zaumoyo, zomwe zingayambitse kukula kwa zizindikiro zosasangalatsa: