Mankhwala Dicinon 250: malangizo ntchito

Dicinon amapezeka pamapiritsi ndi mawonekedwe a yankho la jakisoni.

The yogwira pophika mankhwala ndi ethamsylate. Kuphatikizika kwake piritsi limodzi ndi 250 mg, mu 1 ml ya yankho - 125 mg.

Monga zigawo zothandizira, mapiritsi a Dicinon amaphatikiza anhydrous citric acid, wowuma chimanga, magnesium stearate, povidone K25, lactose.

Kuphatikiza pa ethamylate, yankho limakhala ndi sodium disulfite, madzi a jakisoni, sodium bicarbonate (nthawi zina pamafunika kukonza mulingo wa pH).

Mapiritsi amaperekedwa ku pharmacies m'matumba a 10 m'matumba; matuza 10 amagulitsidwa m'matumba amakatoni. Njira yothetsera makonzedwe amkati ndi mtsempha wam'mimba imazindikira mu galasi lopanda utoto lokhala ndi 2 ml, ma ampoules 10 mu chithuza, matuza asanu mu katoni.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsa ntchito Dicinon kukuwonetsedwa pochiza komanso kupewa kutulutsa magazi m'magazi osiyanasiyana.

Malinga ndi malangizo, etamzilat imagwira ntchito mu:

Kutulutsa magazi kumachitika pakachitika ma pambuyo pa opaleshoni ndi ma cell onse okonzedwa bwino (olowetsedwa ndimitsempha yamagazi) mu minyewa ya m'mimba komanso matenda a m'mimba, machitidwe a ENT, mano, opaleshoni ya pulasitiki, urology, ophthalmology,
Menorrhagia, kuphatikizapo pulayimale, komanso azimayi omwe ali ndi intrauterine akulera,
Kutsekemera kwa mano
Hematuria,
Zamphuno,
Metrorrhagia,
Matenda a shuga a shuga, kuphatikizapo hemophthalmus, hemorrhagic diabetesic retinopathy, etc.,
Matenda a hemorrhagic a kufalitsidwa kwa ubongo mu makanda atsopano, kuphatikiza makanda asanakwane.

Contraindication

Malinga ndi malangizo a Dicinon, kugwiritsidwa ntchito kwa mankhwalawa kumaphwanya wodwala ngati:

Matenda a neoplastic (chotupa) a minyewa yam'mimba komanso ma hematopoietic, kuphatikizapo osteosarcoma, myeloblastic ndi lymphoblastic leukemia,
Supombosis
Acute porphyria,
Supomboembolism
Hypersensitivity pazigawo zam'mapiritsi / yankho.

Dicinon amagwiritsidwa ntchito mosamala kuchiza odwala omwe ali ndi mbiri ya thrombosis kapena thromboembolism, komanso ngati milandu yomwe imayambitsa magazi ndi mankhwala opatsirana ambiri.

Mlingo ndi makonzedwe

Mulingo woyenera wa tsiku ndi tsiku wa Dicinon piritsi la munthu wamkulu amachokera pa 10 mpaka 20 mg pa kilogalamu imodzi ya kulemera kwa thupi. Gawani mu 3 kapena 4 waukulu.

Monga lamulo, pafupifupi limodzi mlingo ndi 250-500 mg, mwapadera limachulukitsidwa mpaka 750 mg. Pafupipafupi kugwiritsa ntchito Dicinon ndi chimodzimodzi, katatu patsiku.

Mu menorrhagia, mlingo wa etamzilate wa tsiku ndi tsiku umachokera ku 750 mg mpaka 1 Dicinon imayamba kutengedwa kuchokera tsiku la 5 la kusamba koyembekezereka mpaka tsiku la 5 la kuzungulira kwotsatira.

Pambuyo pa kuchitapo kanthu pochita opaleshoni, mankhwalawa amalimbikitsidwa kuti atenge maola 6 aliwonse mpaka 250-500 mg. Mapiritsi amapitilizidwa mpaka ngozi yotaya magazi ipitirirabe.

Kwa mwana, mlingo umodzi ndi 10-15 mg pa 1 kg ya kulemera kwa thupi. Kuchulukana kwa ntchito - katatu patsiku.

Malangizo a Dicinon akuwonetsa kuti jakisoni adapangira jakisoni wambiri kapena wolowa mkati. Mu milandu yomwe mankhwalawa amachepetsedwa ndi saline, jekeseni iyenera kuchitidwa mwachangu.

Kwa munthu wamkulu, mlingo wa tsiku ndi tsiku ndi 10-20 mg / kg / tsiku, ayenera kugawidwa majekiseni atatu.

Pazifukwa za prophylactic panthawi yochitidwa opaleshoni, Dicinon amathandizidwa ndi iv kapena IM mu mlingo wa 250-500 mg pafupifupi ola limodzi asanafike opaleshoni. Pakupanga opaleshoni, mankhwalawa amaperekedwa kudzera mu mnofu wofanana, ngati ndi kotheka, kumayambiriro kwa mankhwalawa kumachitika mobwerezabwereza. Mu nthawi ya ntchito, tikulimbikitsidwa kugwiritsa ntchito Dicinon mu gawo loyambirira maola 6 aliwonse mpaka vuto lotaya magazi lithere.

Kwa ana, yankho limayikidwa muyezo wa 10-15 mg / kg / tsiku, logawidwa pawiri jakisoni. Pochita neonatological, Dicinon amalowetsedwa mu minofu kapena pang'onopang'ono kwambiri mumitsempha ya 12,5 mg / kg (mlingo womwe umadziwika wa ethamylate umafanana ndi 0,5 ml ya yankho). Chithandizo chimayamba m'maola awiri oyamba a mwana.

Malangizo apadera

Njira yothetsera jakisoni wa Dicinon imapangidwira kuti idzagwiritsidwe ntchito m'makliniki ndi zipatala.

Sizoletsedwa kusakaniza yankho mu syringe imodzi ndi mankhwala ena aliwonse. Amakanizidwa kuti agwiritse ntchito yankho ngati lasintha mtundu.

Tiyenera kukumbukira kuti Dicinon pa mlingo wa 10 mg / kg, woperekedwa ola limodzi pamaso pa dextrans, amalepheretsa mphamvu yawo ya antiplatelet. Ndipo Dicinon, yemwe adayambitsidwa ndi dextrans, alibe zotsatira zapamwamba.

Dicinone sigwirizana ndi sodium lactate ndi sodium bicarbonate njira jekeseni. Ngati ndi kotheka, ikhoza kuphatikizidwa ndi sodium menadione bisulfite ndi aminocaproic acid.

Piritsi limodzi la Dicinon lili ndi 60,5 mg wa lactose (muyeso wovomerezeka wa chinthu ichi ndi magalamu 5). Mapiritsi ali contraindicated odwala ndi lactase akusowa, kobadwa nako shuga tsankho, malabsorption shuga ndi galactose.

Ngakhale Dicinon adapangira ma intravenous and intravenous management, amatha kuyika timitu, mwachitsanzo, kutulutsidwa kwa dzino kapena pamaso pa bala lina. Pachifukwa ichi, chidutswa cha gauze kapena chosabereka chimalembetsedwa mokwanira ndi yankho ndikugwiritsa ntchito pakuwonongeka.

Migwirizano ndi magwiritsidwe akusungidwa

Dicinon ndi wa gulu la mankhwala omwe amagulitsidwa ndi mankhwala.

Malinga ndi malangizo, mankhwalawa amayenera kusungidwa m'malo otetezedwa ku kuwala ndi chinyezi (mapiritsi), kuchokera kwa ana, komwe kutentha kumasungidwa osapitirira 25 ºС. Alumali moyo wa yankho mu ampoules ndi mapiritsi ndi zaka 5.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Zotsatira za pharmacological

Mankhwala othandizira a Dicinon ndi ethamylate.

Mankhwalawa ali ndi mphamvu ya hemostatic (amayimitsa kapena amachepetsa magazi), zomwe zimachitika chifukwa cha mphamvu ya mankhwalawa kuyambitsa kupangika kwa thromboplastin pamene zombo zazing'ono zimawonongeka (zimapangidwa poyambira magawo oyambira).

Kugwiritsa ntchito Dicinon kungakulitse kupangika kwa mucopolysaccharides (kuteteza ulusi wa mapuloteni ku kuvulala) kwa unyinji waukulu m'makoma a capillaries, kusintha kukula kwa capillaries, kuonjezera kukhazikika kwawo, kusintha microcirculation.

Dicinon alibe mphamvu zowonjezera kuchuluka kwa magazi ndikupanga vasoconstriction, komanso samathandizira pakupanga magazi. Dicinon amayamba kuchita pakapita maola awiri kuchokera pakumwa pakamwa ndi mphindi 5-15 atabayidwa. The achire zotsatira za dicinone zimawonedwa mkati 4-6 maola.

Pharmacokinetics

Ikaperekedwa, etamsylate imatengedwa mwachangu kuchokera m'mimba. Pambuyo pamlomo makonzedwe a 50 mg a ethamsylate, kuchuluka kwambiri kwa plasma (pafupifupi 15 μg / ml) kufikiridwa pambuyo maola 4. The plasma theka moyo ndi maola 3,7. Pafupifupi 72% ya mankhwalawa amatengedwa mkodzo mkati mwa maola 24 oyambirira.

Ethamsylate amadutsa chotchinga kulowa mkaka wa m'mawere.

Mimba komanso kuyamwa

Zotsatira za etamzilate pa amayi oyembekezera sizikudziwika. Ethamsylate imadutsa chotchinga, chifukwa chake ntchito yake imaphatikizidwa mu trimester yoyamba ya mimba. Kugwiritsira ntchito kwamankhwala pathupi sikofunika pazisonyezo izi.

Ethamsylate imadutsa mkaka wa m'mawere. Simuyenera kuyamwitsa pakumwa mankhwalawa.

Mlingo ndi makonzedwe

Gwiritsani ntchito mwa akulu ndi ana opitilira zaka 14

Pamaso pa opareshoni: mapiritsi awiri a Dicinon 250 mg (250-500 mg) kwa ola limodzi musanachite opareshoni.

Pambuyo pakuchita opaleshoni: piritsi limodzi la Dicinon 250 mg (250-500 mg) maola 4 aliwonse, pomwe kuli ndi mwayi wotulutsa magazi.

Matenda amkati: Malangizo ambiri otenga mapiritsi awiri a 250 mg awiri a Dicinon katatu patsiku (1000-1500 mg) ndi chakudya ndi madzi ochepa. Gynecology, ya meno- / metroragia: imwani mapiritsi awiri a Dicinon 250 mg katatu patsiku (1.500 mg) mukamadya ndi madzi ochepa. Mankhwalawa amatenga masiku 10, kuyambira masiku asanu isanayambike magazi.

Mu ana (ana opitilira zaka 6)

Mlingo watsiku ndi tsiku ndi 10-15 mg / kg pa kulemera kwa thupi patsiku, womwe umagawidwa mu Mlingo wa 3-4. Kutalika kwa kugwiritsa ntchito mankhwalawa kumatengera kuchuluka kwa kuchepa kwa magazi ndipo kuyambira masiku 3 mpaka 14 kuchokera panthawi yoletsa magazi m'magulu onse a odwala.

Mapiritsi ayenera kumwedwa nthawi yakudya kapena itatha

Palibe maphunziro a odwala omwe ali ndi vuto la chiwindi kapena impso. Chifukwa chake, ndikofunikira kugwiritsa ntchito Dicinon mosamala m'magulu odwala

Osamatenga mlingo wambiri kuti ulipirire zomwe wasowa.

Zotsatira zoyipa

Zotheka kukhala osagwirizana: kupweteka mutu, chizungulire, nkhope ikuwonekera, kusokonezeka kwa khungu, nseru, kupweteka kwa epigastric, kupweteka kwa mwendo. Izi zimachitika pang'onopang'ono komanso modekha.

Pali umboni kuti mu ana omwe ali ndi pachimake lymphoid ndi myelo native leukemia, osteosarcoma, etamsylate, omwe adalembedwa kupewa kupewa magazi, adayambitsa leukopenia yayikulu. Malinga ndi zambiri zosindikizidwa, kugwiritsa ntchito kwa etamzilate mwa ana kumatsutsana.

Pali umboni kuti azimayi omwe adatenga ethamsilate asana opaleshoni anali ndi thrombosis atachitidwa opaleshoni yamchiberekero. Komabe, mayeso aposachedwa sanatsimikizire izi.

Zolemba ntchito

Mankhwala ayenera kuikidwa mosamala ngati pali mbiri ya thrombosis kapena thromboembolism mwa odwala, kapena hypersensitivity kwa mankhwala. Dicinon imakhala ndi sulfites, ndichifukwa chake chisamaliro chimayenera kuthandizidwanso mukamapereka kwa odwala omwe ali ndi mphumu ya bronchial ndi chifuwa. Musanayambe chithandizo, ziyenera kukumbukiridwa kuti mankhwalawa sagwira ntchito kwa odwala omwe ali ndi thrombocytopenia.

Chifukwa chakuti mwa ana omwe adayikidwa Dicinon popewa kutaya magazi mu pachimake lymphoblastic ndi myeloid leukemia ndi osteosarcoma, vutoli lidakulirakulira, olemba ena amaganiza kuti kugwiritsa ntchito mankhwalawa kunaletsedwa.

Mankhwalawa sayenera kutumizidwa kwa odwala omwe ali ndi matenda achilendo monga kuperewera kwa lactase kapena malabsorption a glucose-galactose.

Ethamsylate sizimakhudza kuyendetsa magalimoto ndi kugwira ntchito ndi makina.

Ngati mumalephera kudya chakudya chambiri, funsani dokotala musanamwe mankhwalawo.

Pharmacodynamics ndi pharmacokinetics

Mankhwalawa amathandizira njira yochokera ku mapulateleti m'mafupakumalimbitsa maphunziro awo. Mankhwala ali ndi antiplatelet ndi angioprotective zotsatira. Mankhwala amathandizira kuti magazi asiye kutuluka, amathandizira kupanga chachikulu thrombusEthamylate imathandizira kutulutsa, sizimakhudza prothrombin nthawimichere ya fibrinogen. Pogwiritsa ntchito mankhwalawa mobwerezabwereza, thrombosis imakulanso. Dicinon amachepetsa maonekedwe a mawonekedwe, magazi kuchokera pakama lamitsempha, amachepetsa kutulutsa, amakhudza bwino kuyesa. Mankhwala samakhudza magawo ndi magawo a magawo a heestatic dongosolo. Dicinon amatha kubwezeretsa nthawi yosintha magazi m'matenda osiyanasiyana.

A heestatic kwenikweni amadzimva pambuyo 10-15 Mphindi. Mulingo wambiri wa zomwe zimagwira ntchito umafikira ola limodzi pambuyo pa makonzedwe. Amayamwa osasinthika tsiku loyamba pafupifupi ndi mkodzo.

Malangizo ogwiritsira ntchito Dicinon

Dicinone akupezeka mu njira yothetsera jakisoni wamkati ndi mu mnofu ndi mapiritsi omwe amafunikira pakamwa. Kugwiritsa ntchito kwa Dicinone kumatha kuthandizanso pogwiritsa ntchito swab yomwe inanyowa mu yankho la bala. Mmodzi wokwanira piritsi limodzi lililonse lili ndi 250 mg ya etamsylate.

Nthawi zambiri, mapiritsi a Dicinon amalimbikitsidwa kuti amwe piritsi la 1-2 pcs. pa nthawi, ngati pangafunike, mlingo utha kuwonjezeka mpaka 3 ma PC. Mlingo umodzi wa yankho la jakisoni nthawi zambiri umafanana ndi ½ kapena 1 ampoule, ngati pangafunike - 1 ½ wokwanira.

Mwa zolinga za prophylactic musanachite opareshoni: 250-500 mg ya etamsylate ndi jekeseni wamkati kapena mu mnofu wa 1 ola limodzi musanachite opaleshoni kapena mapiritsi a 2 a Dicinon maola 3 musanachite opareshoni. Ngati ndi kotheka, mtsempha wa magazi makonzedwe a 1-2 ampoules a mankhwalawa pakuchita opaleshoni ndikotheka.

Kutulutsa magazi mkati ndi m'mapapo kumalimbikitsa kutenga mapiritsi awiri a Dicinon patsiku kwa masiku 5 mpaka 10, ngati pakufunika kuwonjezera njira ya chithandizo, mlingo wa mankhwalawa umachepetsedwa.

Dicinon wokhudzana ndi msambo tikulimbikitsidwa kumwa mapiritsi atatu patsiku kwa masiku 10 - yambani masiku 5 musanathe ndi kutha pa tsiku 5 la msambo. Kuphatikiza izi, mapiritsi a Dicinon ayenera kumwedwa malinga ndi chiwembucho komanso mizere iwiri yotsatira.

Pakadutsa masiku 5 mpaka 14, tikulimbikitsidwa kuti mutenge mapiritsi atatu a Dicinon matenda am'magazi, hemorrhagic diathesis ndi diabetes angiopathies (kuwonongeka kwa mitsempha yamagazi).

Pamaso ntchito kwa prophylactic, ana anaikidwa Dicinon pa 1-12 mg / kg pa tsiku kwa masiku 3-5. Pa opaleshoni, mtsempha wa mtsempha wa 8-10 mg / kg ndiwotheka, ndipo atachitidwa opaleshoni kuti muchepetse magazi - 8 mg / kg mu mapiritsi a Dicinon.

Hemorrhagic syndrome mu ana amathandizidwa ndi pakamwa makonzedwe a 6-8 mg / kg katatu pa tsiku kwa masiku 5-14.

Mu diabetesic microangiopathy, Dicinon akulimbikitsidwa kuti azitha kutumikiridwa intramuscularly pa mlingo wa 125 mg, katatu patsiku kwa miyezi iwiri.

Zotsatira zoyipa

Dicinon, kugwiritsa ntchito komwe kuyenera kuvomerezana ndi adokotala, kungayambitse mavuto osafunikira monga kuwonda kwa epigastric (kumtunda kwa khoma lachiberekero), kupweteka kwamtima, kusefukira kwamitsempha yamagazi kumaso, chizungulire, kupweteka kwa mutu, kutseka kwamiyendo, kutsika kwa magazi, chifuwa.

Kuchita

Osasakanikirana ndi Dicinon ndi mankhwala ena mu syringe yomweyo. Pofuna kupewa antiplatelet ma dextrans Dicinone amaperekedwa ola limodzi asanagwiritse ntchito mlingo wa 10 mg / kg. Kugwiritsa ntchito kwa etamzilate pambuyo pa nthawi imeneyi sikupereka mphamvu. Mankhwala akhoza kuphatikizidwa ndi menadione sodium bisulfite, aminocaproic acid.

Mlingo

Mapiritsi a 250 mg

Piritsi limodzi lili:

ntchito yogwira - etamsylate 250 mg

zokopa: anhydrous citric acid, chimanga wowuma, lactose monohydrate, povidone, magnesium stearate.

Mapiritsi ali ozungulira mawonekedwe, okhala ndi biconvex, kuyambira oyera mpaka pafupi oyera.

Mankhwala

PharmacokineticsZogulitsa Pambuyo pakukonzekera pakamwa, mankhwalawa amayamba pang'onopang'ono kuchokera m'mimba. Mutamwa mankhwalawa mu 500 mg, pazomwe mumagwira magazi m'magazi amatha maola 4 ndipo ndi 15 μg / ml.

Mlingo womangidwa kumapuloteni a plasma pafupifupi 95%. Ethamsylate amadutsa chotchinga. Magazi azimayi ndi ma umbilical chingwe chimakhala ndi kufanana kwa etamsylate. Palibe deta pakugawidwa kwa ethamsylate mkaka wamawere.

Kuswana Etamsylate imathandizidwa ndi impso sizinasinthe. Hafu ya moyo kuchokera m'madzi a m'magazi ndi pafupifupi maola 8. Pafupifupi 70-80% ya mankhwalawa amatengedwa pakatha maola 24 ndi mkodzo wosasinthika.

Pharmacokinetics odwala omwe ali ndi vuto la chiwindi ndi impso

Mankhwala a etamsylate kwa odwala omwe ali ndi vuto la chiwindi ndi impso sanawerenge.

Mankhwala Ethamsylate ndi mankhwala opangira hemostatic ndi angioprotective omwe amagwiritsidwa ntchito ngati gawo loyambirira la hemostatic (mogwirizana ndi endothelium-mapulateleti). Mwa kukonza kuphatikiza kwa kupatsidwa zinthu za m'magazi komanso kubwezeretsa kukana kwa capillary, mankhwalawa amathandizira kuchepetsa kuchepa kwa magazi nthawi ndi kuchepa kwa magazi.

Ethamsylate ilibe vasoconstrictor kwenikweni, sichikhudza fibrinolysis, komanso sasintha plagma coagulation.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Palibe zambiri zamankhwala zokhudzana ndi mwayi wogwiritsa ntchito Dicinon mwa amayi apakati. Kugwiritsa ntchito Dicinon pa nthawi yomwe ali ndi pakati kumatheka pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo.
Palibe deta pakugawidwa kwa ethamsylate mkaka wamawere.
Chifukwa chake, mukamagwiritsa ntchito mankhwalawa panthawi yoyamwitsa, nkhani yosiya kuyamwitsa iyenera kuganiziridwa.