Glucobay: malangizo ogwiritsira ntchito

Kupanga ndi mawonekedwe a kumasulidwa. Mapiritsi a Glucobai, mapiritsi a Glucobai 100. Yogwira pophika: acarbose. Oral antidiabetesic wothandizira. Zigawo zothandiza (mtundu ndi kuchuluka). Glucobai 50: piritsi 1 lili 50 mg ya acarbose. Glokobay 100: piritsi 1 ili ndi 100 mg ya acarbose. Zina zomwe zimapangidwira: Microcrystalline cellulose, omwazika kwambiri a silicon dioxide, magnesium stearate, wowuma chimanga.

Mapale: Phukusi lomwe lili ndi mapiritsi 126 a 100 mg acarbose iliyonse ndi kalendala. Paketi yokhala ndi mapiritsi 30 a 50 mg acarbose iliyonse. Paketi yokhala ndi mapiritsi 30 a 100 mg acarbose iliyonse.

• Zotsatira za pharmacological
• Pharmacokinetics
• Zizindikiro zogwiritsidwa ntchito
• Contraindication
• Zotsatira zoyipa
• Kuchita ndi Mankhwala Ena

Zotsatira za pharmacological. M'mitundu yonse yomwe nyama zaphunziridwa, acarbose imatulutsa matumbo. Kuchita kwa acarbose kumakhazikitsidwa ndi chopinga cha matumbo enzyme (alpha-glucosidase) wochita nawo pakuwola kwa di-, oligo- ndi polysaccharides. Kutengera mlingo, izi zimapangitsa kuti pang'onopang'ono pakonzedwe kazinthu izi. Zotsatira zake, glucose amatulutsidwa pang'onopang'ono kuchokera ku chakudya cham'magazi ndipo amayamba kuyamwa pang'onopang'ono ndi magazi. Chifukwa chake, acarbose amachepetsa kukwera kwa shuga m'magazi atatha kudya. Chifukwa chofanana ndi kuyamwa kwa shuga m'matumbo, kusinthasintha kwa shuga m'magazi masana kumachepetsedwa ndipo pafupifupi magazi a shuga amachepetsa.

Zoopsa. Zoopsa pachimake Maphunziro a poizoni owopsa pambuyo pamlomo ndi mtsempha wa mafinya amachitika mu mbewa, akalulu ndi agalu. Zotsatira zowopsa za poyizoni zikuwonetsedwa patsamba lotsatirali. Kutengera ndi zomwe tafotokozazi, acarbose pambuyo pakamwa yokhayo iyenera kuonedwa ngati yopanda poizoni, mpaka kuchuluka kwa 10g / kg 50 komwe kunali kotheka. Kuphatikiza apo, palibe zodziwika za poizoni zomwe zinaonedwa mwa mtundu wina uliwonse wa nyama zomwe zaphunziridwa mkati mwa mayeso. Pambuyo pokonzekera intravenous, mankhwalawa amakhalanso osachita poizoni.

Chowopsa cha Subchronic. Kafukufuku wololera adachitika kwa miyezi itatu mu makoswe ndi agalu. Acarbose amaphunzitsidwa makoswe pa Mlingo wa 50-450 mg / kg pamlomo. Poyerekeza ndi gulu lolamulira, lomwe silinalandire acarbose, magawo onse a hematological ndi a kuchipatala anali osasinthika. Kufufuza kwotsatira kwa mbiriyakale sikunaperekenso ziwonetsero zakuphwanya konse. Mlingo wamlomo wa 50-450 mg / kg anaphunziranso agalu. Poyerekeza ndi gulu loyang'anira lomwe silinalandire acarbose, kusintha kwa mphamvu ya thupi, nyama ya serum alpha-amylase ndi ndende ya urea zimatsimikiziridwa ndi chinthu choyesera. M'magulu onse omwe amalandira ma Mlingo osiyanasiyana, kusintha kwa kulemera kwa thupi kumawonedwa, zomwe zimafotokozedwa kuti ndi chakudya chokwanira cha 350 g patsiku, zizindikiritso za maguluwo pakatha milungu inayi yoyesera atachepa kwambiri.

Atachulukitsa kuchuluka kwa chakudya mpaka 500 g patsiku sabata la 5 la kuyesako, unyinji wa nyama unakhalabe pamlingo womwewo. Kusintha kwa kulemera kumene, komwe kumachitika chifukwa cha kugwiritsidwa ntchito kwa mankhwala ochulukirapo, ndiwonetsero wa zochita za mankhwala omwe amapezeka muyezo chifukwa chophwanya zakudya za isocaloric (kuchepa kwa chakudya cham'magazi), sikuti ndiwowopsa. Zotsatira zosadziwika za chithandizo, zomwe ndi mtundu wa metabolabolic wa metabolism, kuyambira kuwonda, ziyenera kuonedwanso ngati kukwera pang'ono kwa urea. Kutsika kwa ntchito za alpha-amylase kuyeneranso kuonedwa ngati chizindikiro cha kuchuluka kwa pharmacodynamic.

Mankhwala oopsa Kuyesa kwakanthawi kunachitika pa makoswe, agalu ndi ma hamsters, ndipo nthawi yogwiritsira ntchito agalu inali miyezi 12, makoswe miyezi 24 ndi hamsters masabata 60. Poyeserera makoswe, kuwonjezera pazowonongeka chifukwa chogwiritsa ntchito kwambiri, zotsatira zoyipa zamthupi ziyeneranso kuwululidwa.

Carcinogenicity. Pali maphunziro angapo a carcinogenicity. a) Makoswe a Sprague-Dowley omwe analandiridwa mkati mwa miyezi 24 - 26 ndi chakudya mpaka 4500 μg ya acarbose. Kupatsa acarbose ndi chakudya kumakhala ndi vuto la kusowa kwa zakudya. Muzoyesa izi, poyerekeza ndi kuwongolera, impso parenchyma (adenoma, hypernephroid carcinoma) idapezeka kutengera mtundu wa chotupacho, pomwe kuchuluka konse kwa zotupa (makamaka zotupa za m'magazi) kunachepetsedwa. Pofuna kuthana ndi vuto la kuperewera kwa zakudya m'thupi, m'maphunziro amtsogolo, nyama zimalandira shuga. Pa mlingo wa acarbose 4500 mcg ndi glucose m'malo, kulemera kwa thupi kunali 10% kutsika kuposa gulu lolamulira, kuchuluka kwa zotupa za impso sikunawonedwe.

Pakubwereza kuyesako popanda kusintha kwa glucose, komwe kumatenga miyezi 26, kuwonjezeka kowonjezereka kwa chiwerengero cha zotupa za mayeso a chotupa cha Leydig. M'magulu onse okhala ndi glucose, ma glucose omwe amawonjezera ndiwowonjezereka mwanjira inayake (shuga yodwala matenda a shuga). Ndi kuyambitsa kwa acarbose pogwiritsa ntchito chubu chapamimba, kulemera kwa thupi pamlingo wowongolera, kuchuluka kwa pharmacodynamic ndi njira yotereyi kuyesekera. Chiwerengero cha zotupa ndizosatheka.

b) Makoswe a Wistar adalandira 0 - 4500 μg ya acarbose ndi chakudya kapena kudzera mu chubu chapamimba kwa miyezi 30. Kupatsa acarbose ndi chakudya sikuti kumabweretsa kuwonda. Kuyambira ndi 500 mcg wa acarbose, cecum imakulitsidwa. Chiwerengero chonse cha zotupa zachepetsedwa, palibe chomwe chikuwonetsa kuchuluka kwa zotupa.

c) Hamsters adalandira 0-4000 μg ya acarbose ndipo popanda glucose m'malo mwa masabata 60. Nyama zokhala ndi Mlingo wambiri, kuchuluka kwa mpweya wamagazi ndizofunikira. Chiwerengero cha zotupa sizachulukitsidwa.

Zoopsa zobereka. Maphunziro a Teratogenicity adachitika mu makoswe ndi akalulu. M'mitundu iwiriyi ya nyama, Mlingo wamkamwa wa 0, 30, 120, ndi 460 mg / kg adayesedwa. Mu makoswe, Mlingo unkaperekedwa kuyambira masiku 6 mpaka 15, mu akalulu kuyambira masiku 6 mpaka 18. Mu mitundu yonse ya nyama, palibe zidziwitso zomwe zimapezeka pokomera mphamvu ya acarbose mkati mwazoyesedwa. Mavuto osabereka sanawonedwe mumakutu amuna ndi akazi mpaka mlingo wa 540 mg / kg patsiku. Kugwiritsa ntchito Mlingo mpaka 540 mg / kg patsiku panthawi ya chitukuko cha fetal komanso mkaka wa m'mawere sizinakhudze makoswe ndi ana mu makoswe. Palibe deta pakugwiritsa ntchito panthawi yomwe muli ndi pakati komanso poyamwitsa.

Mutagenicity. Kafukufuku wambiri pa mutagenicity samawonetsa mphamvu ya acotobose.

Pharmacokinetics Glucobay pharmacokinetics anaphunziridwa pa probands pambuyo pakamwa pakompyuta yolemba (200 mg). Popeza pafupifupi 35% ya ma radioacaction onse (kuchuluka kwa zinthu zoletsa komanso zotheka kuwola) adatulutsidwa kwathunthu mkati maora 96, kuchuluka kwa zochedwa zomwe kungachitike kungaganiziridwe osakwanira izi. Gawo lokhala ndi mkodzo wa chinthu chopinga ndi 1.7% ya mlingo womwe umayendetsedwa. 51% ya zochitikazi pasanathe maola 96 idachotsedwa mu ndowe. Mphamvu ya kuchuluka kwa ma radioacase athunthu mu plasma inali ndi nsonga ziwiri. Kutalika kokwanira kofanana ndende ya acarbose okwanira 52.2 +15.7 μg / L pambuyo pa 1.1 + 0,3 maola kumayenderana ndi kusuntha kwazinthu zomwe zimakhala ndi mphamvu ya inhibitory (49.5 + 26.9 μg / L pambuyo pa 2, 2.1 + 1.6 maola).

Mlingo wachiwiri wokwanira 586.3 + 282.7 mcg / L ndipo umatheka pambuyo pa maola 20.7 + 5.2. Mosiyana ndi ma radioacase ambiri, kuchuluka kwa zoletsa zinthu mu plasma ndi magawo 15-20 m'munsi. Lachiwiri, lokwera kwambiri, pambuyo pa maola 14 mpaka 24, likuwoneka chifukwa cha kusungidwa kwazinthu zomwe zimayambitsa mabakiteriya kuchokera mkati mwakuya kwamatumbo. Hafu ya moyo wa inhibitory chinthu kuchokera m'madzi a plasma ndi maola 3.7 + 2.7 kwa gawo logawa komanso maola 9.6 + 4.4 a gawo lodzaza. Malinga ndi mphamvu ya ndende ya plasma, kuchuluka kwa magawo a 0,39 l / kg kwa thupi kungawerengeredwe ma protein.

Bioavailability. Bioavailability ndi 1 - 2%. Gawo lotsika kwambiri, lopezeka mwadongosolo la zinthu zotsogola ndi lofunika komanso lilibe kanthu kuti lingaliro la achire likhale bwanji.

Mlingo. Munthawi zonse, mulingo amasankhidwa ndi dokotala, chifukwa magwiridwe antchito ndi kulolerana ndiosiyana. Pokhapokha pokhapokha atagwiritsidwa ntchito, mulingo wotsatira umagwiritsidwa ntchito: Poyamba: 3 x 1 piritsi la 50 mg ya acarbose patsiku kapena mapiritsi 3 x 1/2 a 100 mg ya acarbose pachikondwerero, ndiye: 3 x 2 mapiritsi a 50 mg a acarbose patsiku kapena 3 x 1 piritsi la 100 mg ya acarbose patsiku: mpaka: 3 x 2 mapiritsi a 100 mg ya acarbose patsiku. Mlingo umatha kuchuluka kwa masabata 1 mpaka 2, ngati kuli kotheka, komanso munthawi yotsatira. Ngati, ngakhale mukutsatira kwambiri zakudyazo, madandaulo amakhalapo, osavomerezeka kupitiliza kuonjezera mlingo, ndipo ngati kuli kotheka, muchepetseni pang'ono. Mlingo wamba ndi 300 mg ya acarbose patsiku (motero 3 mapiritsi 2 a Glucobaya 50 patsiku kapena katatu piritsi 1 la Glucobaya 100 patsiku).

Mapiritsi a Glucobaya amagwira ntchito pokhapokha ngati amwedwa popanda kutafuna ndi madzi pang'ono musanadye. Nthawi yogwiritsira ntchito Glucobay sikhala yochepa.

Contraindication pogwiritsa ntchito glucobai. Hypersensitivity kuti acarbose ndi (kapena) zigawo zina. Popeza palibe deta yokwanira pazokhudza ana ndi achinyamata, Glucobai sayenera kugwiritsidwa ntchito kwa odwala ochepera zaka 18. Matenda akulu m'matumbo omwe amachitika ndi vuto logaya chakudya komanso mayamwidwe. Zinthu zomwe zitha kukhala zowonongeka chifukwa cha kuchuluka kwa kupangika kwamagesi m'matumbo (mwachitsanzo, matenda a Remkheld's, hernias lalikulu, kupindika ndi zilonda zam'mimba). Pa nthawi yoyembekezera, Glucobai sayenera kugwiritsidwa ntchito, popeza palibe zomwe zimachitika ndi amayi apakati. Pambuyo popereka zilembo zokhala ngati acarbose, radioactivity yaying'ono imawonekera pakupanga makoswe mkaka. Kwa anthu, zosankha zofunika sizikupezeka. Popeza kuchuluka kwa ma acarbose mkaka wa m'mawere chifukwa cha mankhwalawa sikuphatikizidwa, ndikulimbikitsidwa pazifukwa zosapatsa glucobai panthawi yoyamwitsa.

Zotsatira zoyipa. Nthawi zambiri phokoso la m'mimba ndi m'mimba, nthawi zina kutsegula m'mimba ndi kupweteka kwam'mimba. Ngati zakudya zomwe zimayikidwa sizikuwonetsedwa kwa odwala omwe ali ndi matenda ashuga, zotsatira zoyipa za m'matumbo zimapangitsidwa. Ngati, ngakhale chisamaliro cha zakudya zomwe zaperekedwa, zovuta zazikulu zimabuka, mwa mgwirizano ndi dokotala, mlingo uyenera kuchepetsedwa kwakanthawi kapena kwa nthawi yayitali. Nthawi zina, motsutsana ndi magwiritsidwe ntchito a Glucobay, asymptomatic (popanda madandaulo) kukwera kwa michere ya chiwindi (kuchuluka kwa transaminases) kumachitika, komwe kumatha kwathunthu pambuyo pakutha kwa chithandizo cha glucobai.

Kuchita ndi mankhwala ena. Zakudya za shuga (nzimbe) ndi zakudya zomwe zimakhala ndi shuga wa chakudya, chifukwa cha kuchuluka kwa mphamvu yamafuta m'matumbo akulu panthawi ya chithandizo ndi glucobai, zimatha kubweretsa zovuta m'matumbo komanso ngakhale kutsegula m'mimba. Glucobai ali ndi antihyperglycemic zotsatira ndipo samayambitsa hypoglycemia. Ngati Glucobay adalembedwa kuwonjezera pa sulfonylurea ndi kukonzekera kwa metformin kapena insulin, ndiye kuti kuchepa kwa shuga m'magazi mpaka kuchuluka kwa hypoglycemic, mlingo wa sulfonylurea ndi metformin kapena insulin uyenera kuchepetsedwa. Ngati hypoglycemia yayamba kwambiri, tiyenera kukumbukira kuti panthawi ya chithandizo ndi Glucobaem, shuga yotsekemera imagwera pang'onopang'ono mu fructose ndi glucose, chifukwa chake sioyenera kuthetsedwa kwa hypoglycemia mwachangu. Chifukwa chake, shuga ya mphesa iyenera kugwiritsidwa ntchito mmalo mwa shuga (nzimbe). Pokhudzana ndi kufooka kwa machitidwe a acarbose, kugwiritsa ntchito antidid, cholestyramine, adsorbents yamatumbo ndi kukonzekera kwa enzyme kuyenera kupewa.

Njira zopewera Sapezeka.

Milandu yayikulu yosagwirizana. Komabe sizikudziwika.

Bongo. Chifukwa cha mankhwala osokoneza bongo ambiri munthawi ya makonzedwe a Glucobay, limodzi ndi zakumwa ndi (kapena) mbale zokhala ndi ma carbohydrate (poly-, oligo-, disaccharides), kufalikira, kutulutsa magazi ndi kutsekula m'mimba kumatha kuchitika. Panthawi yomwe Glucobai amamwa mankhwala osokoneza bongo osadya, zakudya zam'mimba kwambiri siziyenera kuchitika. Ngati bongo uli ndi mankhwala osokoneza bongo, muyenera kukana kumwa zakumwa zozizilitsa kukhosi (ma poly-, oligo-, disaccharides) maora 4-6.

Mayendedwe ena. Kutsatira kwambiri zakudya za odwala omwe ali ndi matenda ashuga, motero, ndikofunikanso pochotsa glucobaemia. Simungasokoneze kudya kwa Glucobay kopanda upangiri popanda dokotala, chifukwa shuga ya magazi imakwera. Odwala omwe amathandizidwa ndi zakudya zokha, Glucobai sayambitsa hypoglycemia. Ngati mukumwa mankhwalawa ndi Glucobaem chifukwa chosowa kwambiri insulin odwala omwe amalandila chithandizo cha sulfonylurea kapena metformin, hypoglycemia imachitika, shuga wa mphesa (osati chakudya, nzimbe, shuga) uyenera kumwedwa. Chithandizo cha glucobai ziyenera kuyikidwa mgulu la wodwala yemwe ali ndi matenda ashuga.

Moyo wa alumali. Mu phukusi loyambirira, mapiritsiwa amasungidwa zaka 4.

Malo osungira. Pamatenthedwe oposa 25 ° C ndi chinyezi chaching'ono m'chipindacho pamwamba pa 75 H, mapiritsi omwe amachotsedwa pamatayala amatha kusweka. Chifukwa chake, mapiritsi amayenera kuchotsedwa mufilimu musanayambe kugwiritsa ntchito.

Kupumula kwa mankhwala. Monga adanenera dokotala. Mankhwalawa ali ndi zinthu zomwe zimapangitsa sayansi ya zamankhwala sizikudziwika bwino. Chifukwa chake, wabizinesi wazamankhwala ayenera kugonjera kuulamuliro wothandizidwa ndi boma pazomwe zachitika pakugwiritsa ntchito mankhwalawa malinga ndi Article 549, Ndime 6 ya Lamulo pa Mankhwala.

Wopanga Bayer AG 5090 Leverkusen-Bayerwerk

Kugwiritsa ntchito mankhwala a glucobai pokhapokha ngati adokotala adalembera, malangizo ndi omwe amapereka!

Basic zida zachilengedwe

mapiritsi oyera kapena achikasu kumbali imodzi ya piritsi la 50 mg lochotsedwa ndi "G 50", mapiritsi a 100 mg - "G 100" ndi notch, mbali inayo mapiritsi 100 mg - gehena, mapiritsi 50 mg - wolemba mawonekedwe a Bayer mtanda ,

Piritsi limodzi lili ndi acarbose 50 mg kapena 100 mg

zokopa: aerosil (colloidal silicon dioxide), magnesium stearate, wowuma chimanga, cellcrystalline cellulose.

Mankhwala

Mankhwala. Yogwira pophika mankhwala - acarbose, ndi pseudotetrasaccharide wa Microbial chiyambi. Acarbose amachita pamlingo wamatumbo, kulepheretsa ntchito ya michere yaying'ono yamatumbo (alpha-glucosidases), yomwe imakhudzana ndi kuphwanya kwa di-, oligo- ndi polysaccharides. Zotsatira zake, pamakhala kuchepetsedwa ndi mlingo wa mafuta omwe amapezeka m'matumbo, kenako ndikuwamasula ndikuchedwa kwa shuga, omwe amapangika pakuwonongeka kwa chakudya. Chifukwa chake, kuchepa kwa acarbose ndikuchepetsa kuchuluka kwa shuga m'magazi. Chifukwa chotengeka ndi shuga m'matumbo, pafupifupi ndende komanso kusinthasintha kwake m'magazi kumachepa. Pankhani yowonjezera kuchuluka kwa glycosylated hemologlobin, acarbose imachepetsa mulingo wake.

Zogulitsa. Pafupifupi 35% ya mlingo wothandizidwa umayamwa mu mawonekedwe a metabolites, ochepera 2% mu mawonekedwe akugwira. Amapukusidwa m'migawo ya m'mimba, makamaka ma bakiteriya am'mimba ndipo mwanjira ina mwa kupukusa michere ndi mapangidwe 13 osakanikirana a mawonekedwe a sulfate, methyl ndi glucuronic conjugates. Mukatha kugwiritsa ntchito mankhwalawa, pali nsonga ziwiri paziphuphu zakumagazi m'magazi am'magazi, pafupifupi 52.2 ± 15.7 μg / L pambuyo pa 1.1 ± 0.3 h ndi 586.3 ± 282.7 Lg / L pambuyo pa 20 7 ± Maola 5.2, motsatana. Amakhulupirira kuti kuwonekera kwa nsonga yachiwiri kudachitika chifukwa cha kuyamwa kwa zinthu zowonongeka za bakiteriya kuchokera m'malo okuya am'matumbo aang'ono.

Kugawa. Voliyumu yogawa ndi 0,32 l / kg thupi.

Bioavailability. Bioavailability ndi 1-2% yokha. Zochepa kwambiri zokhala ndi mankhwala zomwe zimapezeka pokhapokha zimafunikira chifukwa ma acarbose amachita m'matumbo ochepa. Ngakhale izi, bioavailability wotsika samakhudza kuchiritsa kwa mankhwalawa.

Pomaliza Hafu ya moyo wogawika ndikugawa magawo ndi ma 3.7 ± 2.7 maola ndi 9.6 ± maola 4.4, motere, 51% yazomwe zimagwira ntchito zimatulutsidwa m'matumbo, 1.7% osasinthika komanso ngati metabolite yogwira, ndi 34% mu mawonekedwe a metabolites - kudzera impso.

Kuphatikiza mankhwala a shuga kuphatikiza zakudya.

Kupewa kwa mtundu wachiwiri wa shuga m'matenda a odwala omwe ali ndi vuto loleza shuga (PTH *) kuphatikiza zakudya komanso masewera olimbitsa thupi.

Mlingo ndi makonzedwe

Mlingo woyenera umakhazikitsidwa payekhapayekha kwa wodwala aliyense, popeza momwe mankhwalawa amagwiritsidwira ntchito komanso amatha kulolera mosiyanasiyana.

Mapiritsi amatengedwa popanda kutafuna, ndimadzi pang'ono, nthawi yomweyo musanadye kapena kutafuna ndi chakudya choyamba.

Kutalika kwa chithandizo sikochepa.

Kuphatikiza mankhwala a shuga kuphatikiza zakudya.

Mlingo woyambirira ndi piritsi limodzi la 50 mg katatu pa tsiku kapena piritsi la ½ 100 mg katatu patsiku. Kenako, ngati pakufunika kutero, mlingowo utha kuwonjezeka mpaka 100 mg katatu pa tsiku (mapiritsi 2 a 50 mg katatu pa tsiku kapena piritsi limodzi la 100 mg katatu pa tsiku).

Nthawi zina, ngati pakufunika, mlingo wa mankhwalawa utha kuwonjezeka mpaka 200 mg katatu patsiku.

Ndikulimbikitsidwa kuwonjezera mlingo wa mankhwalawa pambuyo pa masabata 4-8 ngati njira yofunikira ya kachipatala sinapezeke mwa odwala omwe adalandira mlingo woyamba. Ngati wodwalayo ali ndi zodandaula za kukhala wathanzi, ngakhale kuti amatsatira kwambiri zakudyazo, ndiye kuti kuchuluka kwa mankhwalawa kuyenera kuyimitsidwa, ndipo ngati kuli koyenera, ngakhale kuchepetsedwa pang'ono. Pafupifupi tsiku lililonse Glucobai ® ndi 300 mg ya acarbose patsiku.

Kupewa kwa mtundu wachiwiri wa shuga m'matenda a odwala omwe ali ndi vuto la glucose kuloleza kuphatikiza zakudya komanso masewera olimbitsa thupi.

Mlingo woyenera wochizira matenda amtundu wa II odwala omwe ali ndi vuto la shuga amayenda ndi 100 mg katatu patsiku.

Mlingo woyambirira ndi 50 mg kamodzi patsiku (piritsi limodzi la 50 mg kapena piritsi ya 100 mg kamodzi patsiku). Pakupita miyezi itatu, mlingo umakulitsidwa mpaka 100 mg katatu pa tsiku (mapiritsi 2 a 50 mg katatu pa tsiku kapena piritsi limodzi la 100 mg katatu pa tsiku).

Odwala okalamba (opitilira 65): Kusintha kwa mankhwalawa sikofunikira.

Odwala omwe ali ndi vuto la kuchepa kwa chiwindi safuna kusintha kwa mlingo.

Contraindication

• Hypersensitivity kuti acarbose ndi / kapena Excipients.
• Matenda aakulu m'matumbo omwe ali ndi vuto logaya chakudya komanso mayamwidwe.
• Zotsatira zomwe zimaphatikizidwa ndi flatulence (Remkheld's syndrome, hernias yayikulu, stenosis ndi zilonda zam'mimba).
• Kulephera kwakukulu kwa aimpso (kulengedwa kwa creatinine

Bongo

Ngati mlingo waukulu wa Glucobay ® umagwiritsidwa ntchito nthawi yomweyo ndi zakumwa ndi / kapena zakudya zomwe zili ndi ma carbohydrate (poly-oligo- kapena disaccharides), mankhwala osokoneza bongo amatha kukhala limodzi ndi flatulence ndi kutsekula m'mimba.

Pankhani ya bongo, tikulimbikitsidwa kuti zakumwa zakumwa zozizilitsa kukhosi zimaperekedwa kunja kwa chakudya kwa maola 4-6.

Pakakhala kuchuluka kwa mapiritsi a mankhwalawa, palibe chitukuko cha zomwe zimayambira m'matumbo zimayembekezeredwa kunja kwakudya.

Zolemba ntchito

Ndikulimbikitsidwa kuti kuchuluka kwa ma enzymes a "chiwindi" kuyang'aniridwa m'miyezi isanu ndi umodzi yoyambirira, popeza mukamagwiritsa ntchito mankhwalawa, kuwonjezeka kwa asymptomatic pamlingo wa michere ya "chiwindi" kumatheka. Monga lamulo, atasiya kugwiritsa ntchito mankhwalawa, zochitika zawo zimakhala zofanana.

Kuchita bwino ndi chitetezo cha acarbose mwa odwala osakwana zaka 18 sizinakhazikitsidwe.

Ngati osagwirizana ndi zakudya zotchulidwa ndi adotolo, zimayambitsa zovuta m'matumbo. Ngati matendawa akuchulukirachulukira, ngakhale zakudya zikutsatiridwa kwambiri, ndikofunikira kukaonana ndi dokotala ndikuchepetsa mankhwalawa kwa nthawi yayitali kapena yayitali.

Potengera momwe mankhwalawo amathandizira ndi Glucobai ®, kugwiritsa ntchito sucrose (shuga ya chakudya) ndi zinthu zomwe zili momwemo zimatha kusokoneza m'mimba komanso kutsegula m'mimba chifukwa chakuwonjezera mphamvu kwa chakudya m'matumbo.

Glucobai ® imawonetsa zotsatira za hypoglycemic, koma sizimayambitsa hypoglycemia mwa odwala.

Pogwiritsa ntchito mankhwalawa Glucobai ® sucrose (shuga ya chakudya) imang'ambika pang'onopang'ono kulowa mu fructose ndi glucose, chifukwa chake sizoyenera kusintha mwachangu kwa hypoglycemia yachangu. Pankhaniyi, shuga iyenera kugwiritsidwa ntchito.

Mimba komanso kuyamwa

Popeza palibe chidziwitso pakugwiritsa ntchito mankhwalawa Glucobay ® pa nthawi yomwe ali ndi pakati, sikulimbikitsidwa kuti ayike amayi apakati.

Pambuyo pokhazikitsa radiolabeled acarbose isotope ku makoswe achikazi panthawi yotsekera, pang'onopang'ono radioacaction idapezeka mkaka. Palibe zambiri zogwirizana ndi anthu. Komabe, popeza zomwe zimapangitsa kuti mwana akhale wakhanda chifukwa cha kupezeka kwa ma acarbose mkaka wa m'mawere sakukhudzidwa, ndiye kuti sikulimbikitsidwa kupereka mankhwala a Glucobai ® pa nthawi ya mkaka wa mkaka.

Kukopa pa kuyendetsa galimoto ndi makina.

Palibe deta pazomwe zimachitika pa kuyendetsa ndikugwiritsa ntchito makina.

Kuchita ndi mankhwala ena

Ngati Glucobai ® imayikidwa limodzi ndi insulin kapena kukonzekera komwe kumakhala ndi sulfonylureas kapena metformin, kuchuluka kwa shuga m'magazi kumatha kutsikira ku hypoglycemic range (mwanjira zina, kuperewera kwa hypoglycemic kungayambike), komwe kumafuna kuchepetsedwa kwa mlingo wawo.

Nthawi zina, acarbose imatha kukhudzanso bioavailability wa digoxin, yomwe imaphatikizapo kufunika kosintha mlingo wotsiriza.

Sikulimbikitsidwa kuphatikiza Glucobai ® ndi cholestyramine, matumbo am'mimba ndi kukonzekera kwa enzyme chifukwa chogwira bwino ntchito ya acarbose.

Palibe kuyanjana kwa mankhwala ndi dimethicone / simethicone komwe kunawonedwa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi okhala ndi mbali:

• 50 mg: kuzungulira, biconvex, oyera kapena oyera oyeraasoasoasoake, wokhala ndi chithunzi cha "G50" mbali imodzi ndikuyika makina (Bayer mtanda) mbali inayo,
• 100 mg: oblong, biconvex, yoyera kapena yoyera mwachikasu, yokhala ndi notch mbali zonse ziwiri, ndikujambula chithunzi "G100" mbali imodzi.

Mapiritsi ali ndi zidutswa 15. matuza, matuza awiri kapena 8 amadzaza mkatoni.

Chithandizo chogwira ntchito: acarbose, piritsi limodzi - 50 kapena 100 mg.

Zothandiza zothandizira: anhydrous colloidal silicon dioxide, wowuma chimanga, magnesium stearate, microcrystalline cellulose.

Zotsatira za pharmacological Glucobay

Glucobai ndi othandizira a hypoglycemic pakugwiritsa ntchito pakamwa. Yogwira pophika mankhwala ndi acarbose. Izi zimakhazikika pamlingo wa glucose m'magazi.

Kodi mankhwalawa amagwira ntchito bwanji? Acarbose ndi chinthu chomwe chimalepheretsa matumbo alpha glucosidase. Yogwira pophika mankhwala amachepetsa kusintha kwa enzymatic kwa ma disaccharides, oligosaccharides ndi polysaccharides kukhala monosaccharides. Chifukwa cha izi, kuchuluka kwa mayamwidwe m'matumbo amachepa.

Ndizofunikira kudziwa kuti kugwiritsa ntchito mapiritsi, hypoglycemia yayikulu sikupita patsogolo. Kugwiritsa ntchito mankhwala pafupipafupi kumachepetsa chiopsezo:

1. Myocardial infaration.
2. Kuukira kwa hypoglycemia ndi hyperglycemia.
3. Kukula kwa matenda opatsirana a mtima.

Pazitali kwambiri pazogwira ntchito m'magazi zimawonedwa pambuyo pa maola 1-2. Zosagwira metabolites za mankhwalawa zimapukusidwa m'matumbo, impso ndi chiwindi.

Malangizo ogwiritsira ntchito mankhwalawa

Mukasankha Glucobai, malangizo ogwiritsira ntchito akuyenera kuphunzira, chifukwa ili ndi chidziwitso chonse, zisonyezo, zotsutsana ndi zoyipa. Kodi ndikofunika kumwa mankhwalawa munthawi iti?

Malangizowo akuti mankhwalawa amayenera kugwiritsidwa ntchito pa zovuta za matenda a shuga 1. Chizindikiro chogwiritsidwira ntchito ndi mtundu wa 2 shuga. Mutha kugwiritsa ntchito mankhwalawa kunenepa kwambiri komanso matenda a shuga.

Koma kuchepa thupi mothandizidwa ndi Glucobay ndizotheka pokhapokha mutatsatira zakudya zapadera. Ndikofunika kudziwa kuti munthu wonenepa ayenera kudya pafupifupi kilomita 1000 patsiku. Kupanda kutero, hypoglycemia ikhoza kukhala, mpaka kuukira kwa hypoglycemic.

Momwe mungamwe mankhwalawo? Imwani mapiritsi musanadye. Mlingo woyambirira ndi 150 mg. Gawani tsiku lililonse mu 3 waukulu. Ngati ndi kotheka, mlingo umakwezedwa ku 600 mg. Koma mu nkhani iyi, tsiku ndi tsiku mlingo uyenera kugawidwa mu 3-4 Mlingo.

Ngati munthawi ya chithandizo, wodwalayo amakhala ndi vuto lotsekula m'mimba, ndiye kuti mlingo wake uyenera kuchepetsedwa, kapena mankhwalawo amayenera kusokonezedwa palimodzi. Kutalika kwa chithandizo ndi Glucobaem amasankhidwa payekhapayekha.

Contraindication kumwa mapiritsi:

• Ziwengo magawo a mankhwala.
• Zaka za ana. Mankhwalawa sanalembedwe kwa odwala azaka zosakwana 18.
• Kukhalapo kwa matenda owopsa kapena matumbo. Ndemanga za madokotala zikuwonetsa kuti mankhwalawa ndiwowopsa kupereka kwa anthu omwe ali ndi vuto la matumbo.
• Matenda a shuga ketoacidosis.
• Kuphwanya chiwindi. Ndi zoletsedwa kugwiritsa ntchito mankhwalawa ngati munthu akudwala chiwindi, matenda a chiwindi kapena chiwindi.
• Zilonda zam'mimba kapena ziwalo zina zam'mimba thirakiti.
• Nthawi yapakati.
• Nthawi yonyamula. Koma malangizowo akuti mankhwalawa amatha kuikidwa kuti akachulukitse azimayi pokhapokha kuyimitsidwa kwakanthawi kanyumba
• Kulephera kwamkati (ndi zomwe zili ndi creatinine pamtunda wa 2 ml pa 1 dl).
• A Remgeld's syndrome.
• Kukhalapo kwa hernias yayikulu mkati mwa khoma lam'mimba.
• Malabsorption syndrome kapena maldigestion.

Mosamala, mankhwalawa amaperekedwa kwa anthu atachitidwa opaleshoni. Komanso kusintha mtundu wa mankhwalawo kungakhale kofunikira ngati munthu akudwala matenda opatsirana kapena kutentha thupi. Ndikofunika kudziwa kuti mukamalandira chithandizo, mankhwala omwe amakhala ndi sucrose yambiri sangathe kudya. Kupanda kutero, zizindikiro za dyspeptic zimayamba.

Kodi Glucobai amalumikizana bwanji ndi mankhwala ena? Zinapezeka kuti mankhwalawa sagwira ntchito bwino ngati matumbo amatenga, ma antacid, kapena kukonzekera kwa enzyme. Tiyeneranso kudziwa kuti kugwiritsa ntchito Glucobay munthawi yomweyo pogwiritsa ntchito mankhwala a sulfonylurea kapena insulin, mphamvu ya hypoglycemic imatheka.

Ndikulimbikitsidwa kwambiri kuti musagwiritse ntchito chida ichi limodzi ndi thiazide diuretics, kulera kwamlomo, corticosteroids, nicotinic acid. Ndi kulumikizana kwawo, kuwonongeka kwa matenda ashuga kumatha. Komanso, matenda amtunduwu amatha kupanga ngati mutatenga phenothiazines, estrogens, isoniazid, calcium blockers, adrenomimetics nthawi yomweyo monga Glucobai.

Mukamagwiritsa ntchito mapiritsi a Glucobai, pali kuthekera kwa mawonekedwe a zotsatirapo zake:

1. Kuchokera pamimba yokhudza chakudya: kupweteka kwa epigastric, nseru, kutsegula m'mimba, kusisita. Ngati bongo, pali kuthekera kwa kuchuluka kwa asymptomatic pamagawo a ziwindi za chiwindi. Milandu imadziwikanso pamene kutsekeka m'matumbo, jaundice ndi hepatitis amapezeka panthawi ya chithandizo.
2. Thupi lawo siligwirizana.
3. Kutupa.

Pankhani ya bongo, anaphylactic zimachitika. Pankhaniyi, chithandizo chamankhwala chimachitika.

Analogue yabwino kwambiri ya Glucobay

Ngati Glucobay adatsutsana pazifukwa zilizonse, ndiye kuti wodwalayo adapatsidwa gulu lake. Mosakayikira, njira yabwino kwambiri pa chida ichi ndi Glucofage. Mankhwalawa amagwiritsidwanso ntchito pochiza matenda a shuga amtundu 1 komanso 2. Mtengo wa mankhwalawo m'mafakisi ndi 500-700 rubles.

Anthu ambiri ali ndi chidwi ndichomwe pali kusiyana pakati pa Glucofage ndi Glucobay. Kusiyana kwakukulu pakati pa mankhwalawa ndi kapangidwe ndi mfundo zoyenera kuchitapo. Koma onsewa amagwiranso ntchito.

Kodi glucophage imagwira ntchito bwanji? Gawo lomwe limagwiritsa ntchito mankhwalawo limatchedwa metformin. Katunduyu ali ndi tanthauzo la hypoglycemic. Ndikofunikira kudziwa kuti odwala omwe ali ndi shuga omwe ali ndi shuga, metformin ilibe mphamvu.

Kupanga kwa Glucofage kumachitika chifukwa cha mphamvu ya gawo lake lomwe limapangitsa kuti maselo azikhala ndi insulin komanso kuti achepetse kuthamanga kwa shuga m'mimba. Chifukwa chake, mankhwalawa amathandizira:

• Anachepetsa kapangidwe ka shuga m'chiwindi.
• Kukondoweza kwa kugwiritsidwa ntchito kwa glucose mu minofu minofu.
• Sinthani kagayidwe ka lipid.
• Cholesterol otsika, triglycerides ndi lipoproteins, omwe amakhala ndi otsika kwambiri.

Glucophage imatha kusiyanitsidwa ndi kuthekera kwake kuchokera ku mankhwala ena a hypoglycemic. Izi ndichifukwa choti mankhwalawa ali ndi zizindikiro zambiri za bioavailability. Amapanga pafupifupi 50-60%. Pazitali kwambiri pazogwira zinthu zomwe zimapezeka m'magazi zimawonedwa pambuyo pa maola 2,5.

Momwe mungamwe mankhwalawo? Muyenera kumwa mapiritsi pakudya kapena musanadye. Mlingo wa tsiku ndi tsiku nthawi zambiri amakhala magalamu awiri a 2-3 (2000-3000 mamililita). Ngati ndi kotheka, pakatha masiku 10-15, mlingo umakulitsidwa kapena kuchepa. Mlingo wokonza ndi 1-2 magalamu. Ndikofunika kudziwa kuti mlingo wa tsiku ndi tsiku umasiyana. Munjira zambiri, zimatsimikiziridwa ndi mlingo wa insulin.

Mankhwala oletsedwa ndi:

1. Matupi a ziwalo zamagulu a glucophage.
2. Kulephera kwina.
3. Kuphwanya chiwindi.
4. Kuthetsa madzi m'thupi.
5. Kulephera kopindulitsa.
6. Matenda opatsirana.
7. Lactic acidosis.
8. Matenda a shuga.
9. Acute myocardial infarction (mbiri).
10. Zakudya za Hypocaloric (zosakwana ma kilocalories 1000 patsiku).
11. Mimba komanso kuyamwa.

Mukamagwiritsa ntchito mankhwalawa, kusokonezeka komwe kumagwira ntchito m'mimba, CCC ndi hematopoietic dongosolo limatha kukhazikika. Palinso kuthekera kwa vuto la metabolic. Nthawi zambiri, mavuto amayamba ndi mankhwala osokoneza bongo.

Kanemayo munkhaniyi akukamba za zabwino komanso zoipa za mankhwala a Glucobay.