Amoxiclav - malangizo, ntchito, ndemanga, analogs ndi mitundu (mapiritsi a 125 mg, 250 mg, 500 mg, 875 mg, 1000 mg, kuyimitsidwa) kwa mankhwala ochizira matenda opatsirana akuluakulu, ana ndi mimba

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Amoxiclav. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Amoxiclav pamachitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Analogs a Amoxiclav kukhalapo kwa mapangidwe anthawi zophatikizika. Gwiritsani ntchito mankhwalawa matenda osiyanasiyana opatsirana akuluakulu, ana, komanso panthawi yoyembekezera komanso mkaka wa m`mawere. Kugwiritsa ntchito moledzera komanso zotsatira zomwe zingachitike mutatenga Amoxiclav.

Amoxiclav - ndi kuphatikiza kwa amoxicillin - semisynthetic penicillin wokhala ndi mawonekedwe osiyanasiyana a antibacterial zochita ndi clavulanic acid - choletsa-lactamase inhibitor chosasinthika. Clavulanic acid imapanga khola losakhazikika ndi ma enzyme amenewa ndikuwonetsetsa kukana kwa amoxicillin pazotsatira za beta-lactamases zopangidwa ndi tizilombo.

Clavulanic acid, yofanana ndi mankhwala a beta-lactam, ali ndi mphamvu yofooka ya antibacterial.

Amoxiclav ali ndi mawonekedwe osiyanasiyana a antibacterial kanthu.

Imagwira ntchito pothana ndi zovuta zomwe zimakhudzidwa ndi amoxicillin, kuphatikiza tizilombo ta beta-lactamases, incl. aerobic gram-virus bacteria, aerobic gram-negative bacteria, anaerobic gram-positive bacteria, anaerobic gram-negative anaerobes.

Pharmacokinetics

Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana. Zonsezi zimapangidwa bwino mutatha kumwa mankhwalawo mkati, kudya sikumakhudza kuchuluka kwa mayamwidwe. Zonsezi zimadziwika ndi kuchuluka kogawika m'madzi amthupi ndi minyewa (mapapu, khutu lapakati, zotulutsa ndi zotumphukira za chiberekero, chiberekero, mazira, ndi zina). Amoxicillin imalowanso madzi ophatikizika a chiwindi, chiwindi, matumbo a prostate, minofu ya palatine, minofu ya minyewa, chikhodzodzo, kutsekeka kwa mphuno, malovu, kubisala kwa bronchial. Amoxicillin ndi clavulanic acid simalowa BBB ndi mauna osavulala. Amoxicillin ndi clavulanic acid amawoloka zochuluka zotchinga ndipo mumayang'anira kuchuluka amatsitsidwa mkaka wa m'mawere. Amoxicillin ndi clavulanic acid amadziwika ndi zomanga zochepa m'mapuloteni a plasma. Amoxicillin amaphatikizidwa pang'ono, asidi clavulanic mwachidziwikire amatha kuyamwa kwambiri. Amoxicillin amachotseredwa ndi impso pafupifupi osasinthika ndi kubisala kwa tubular ndi kusefera kwa glomerular. Clavulanic acid imapukusidwa ndi kusefera kwa glomerular, mwanjira ina ya metabolites.

Zizindikiro

Matenda oyambitsidwa ndi tizilombo tating'onoting'ono tating'ono:

matenda a chapamwamba kupuma thirakiti ndi ENT ziwalo (kuphatikizapo pachimake ndi matenda sinusitis, pachimake ndi matenda otitis TV, pharyngeal abscess, tonsillitis, pharyngitis),
matenda am'munsi kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, matenda opha ziwalo, chibayo),
matenda a kwamkodzo thirakiti
matenda azamatenda
matenda a pakhungu ndi minofu yofewa, kuphatikiza kulumidwa kwanyama ndi anthu,
matenda a mafupa ndi osakanikirana,
matenda am'mimba thirakiti (cholecystitis, cholangitis),
matenda odontogenic.

Kutulutsa Mafomu

Ufa pokonzekera jekeseni wa mtsempha wa magazi (4) 500 mg, 1000 mg.

Ufa pakukonzekera kuyimitsidwa kwa makonzedwe apakamwa a 125 mg, 250 mg, 400 mg (fomu yabwino kwa ana).

Mapiritsi okhala ndi mafilimu 250 mg, 500 mg, 875 mg.

Malangizo ogwiritsira ntchito ndi mlingo

Akuluakulu ndi ana opitirira zaka 12 (kapena zopitilira 40 makilogalamu a kulemera kwa thupi): mulingo woyenera wa matenda opatsirana pang'onopang'ono ndi piritsi limodzi 250 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi 500 500 + 125 mg maola 12 aliwonse, ngati ali ndi matenda oopsa ndi matenda amtundu wamapapo - 1 piritsi 500 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 875 + 125 mg maola 12 aliwonse.Mapiritsi sinafotokozeredwe ana osakwana zaka 12 (ochepera 40 makilogalamu a thupi).

Mlingo wapamwamba wa tsiku ndi tsiku wa clavulanic acid (munthawi ya mchere wa potaziyamu) ndi 600 mg kwa akulu ndi 10 mg / kg yolemetsa wa ana. Mlingo wapamwamba wa tsiku ndi tsiku wa amoxicillin ndi 6 ga kwa akulu ndi 45 mg / kg ya thupi kwa ana.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Mlingo wa matenda odontogenic: 1 tabu. 250 +125 mg maola 8 aliwonse kapena piritsi limodzi 500 + 125 mg maola 12 aliwonse masiku 5.

Mlingo wa kulephera kwa aimpso: kwa odwala omwe amalephera kupweteka aimpso (Cl creatinine - 10-30 ml / min), mlingo ndi tebulo limodzi. 500 + 125 mg maola 12 aliwonse, kwa odwala omwe amalephera kwambiri aimpso (creatinine Cl osakwana 10 ml / min), mlingo ndi tebulo limodzi. 500 + 125 mg maola 24 aliwonse

Zotsatira zoyipa

Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.

kusowa kwa chakudya
kusanza, kusanza,
kutsegula m'mimba
kupweteka m'mimba
pruritus, urticaria, zotupa za erythematous,
angioedema,
anaphylactic shock,
mziwindi vasculitis,
dermatitis exfoliative,
Matenda a Stevens-Johnson
leukopenia wosinthika (kuphatikizapo neutropenia),
thrombocytopenia
hemolytic anemia,
eosinophilia
chizungulire, kupweteka mutu,
kukomoka (kumachitika kwa odwala mkhutu aimpso ntchito akamamwa mankhwala kwambiri),
kumverera kwa nkhawa
kusowa tulo
interstitial nephritis,
khalid
kukula kwa zamphamvu (kuphatikizapo candidiasis).

Contraindication

Hypersensitivity ku zilizonse za mankhwala,
Hypersensitivity m'mbiri mpaka penicillin, cephalosporins ndi mankhwala ena a beta-lactam,
mbiri ya umboni wa cholestatic jaundice komanso / kapena chiwindi china chovulala chifukwa chotenga amoxicillin / clavulanic acid,
matenda mononucleosis ndi lymphocytic leukemia.

Mimba komanso kuyamwa

Amoxiclav imatha kutumikiridwa panthawi yomwe ali ndi pakati ngati pali mawonekedwe omveka.

Amoxicillin ndi clavulanic acid ang'onoang'ono amachotsedwa mkaka wa m'mawere.

Malangizo apadera

Ndi njira ya chithandizo, ntchito za magazi, chiwindi ndi impso ziyenera kuyang'aniridwa.

Odwala kwambiri mkhutu aimpso ntchito, kukonzekera koyenera wa dosing regimen kapena kuwonjezeka kwa pakati pakati pa dosing kumafunika.

Pofuna kuchepetsa chiopsezo cha zovuta kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwa ndi zakudya.

Mayeso a Laborator: kuchuluka kwa amoxicillin kumapereka mayankho olakwika a mkodzo akamagwiritsa ntchito njira ya Benedict kapena Reelling's. Enzymatic zimachitikira ndi glucosidase tikulimbikitsidwa.

Ndi zoletsedwa kugwiritsa ntchito Amoxiclav ndi mowa womwewo munthawi iliyonse, popeza chiwopsezo cha matenda amtundu wa chiwindi pakumawamwa nthawi yomweyo chikukula kwambiri.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Palibe deta pazovuta za Amoxiclav mu Mlingo wolimbikitsidwa pa kuyendetsa galimoto kapena kugwira ntchito ndi makina.

Kuyanjana kwa mankhwala

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Amoxiclav ndi maantacididi, glucosamine, mankhwala othandizira, aminoglycosides, mayamwidwe amachepetsa, ndi ascorbic acid - ukuwonjezeka.

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatseka kubisalira kwa tubular kumawonjezera kuchuluka kwa amoxicillin (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Ndi munthawi yomweyo kugwiritsa ntchito Amoxiclav kumawonjezera kawopsedwe wa methotrexate.

Pogwiritsa ntchito munthawi yomweyo Amoxiclav ndi allopurinol, zochitika za exanthema zimawonjezeka.

Makonzedwe oyanjana ndi disulfiram ayenera kupewedwa.

Nthawi zina, kumwa mankhwalawa kungakulitse nthawi ya prothrombin, motere, kusamala kuyenera kugwiritsidwa ntchito popereka mankhwala anticoagulants ndi Amoxiclav.

Kuphatikiza kwa amoxicillin ndi rifampicin ndikutsutsana (pali kufooka kwa mphamvu ya antibacterial).

Amoxiclav sayenera kugwiritsidwa ntchito nthawi imodzi ndi mankhwala opatsirana a bacteriostatic (macrolides, tetracyclines), sulfonamides chifukwa kuchepa kwa mphamvu ya Amoxiclav.

Probenecid amachepetsa kuwonongeka kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu.

Maantibayotiki amathandizira kuchepetsa kupatsirana kwa pakamwa.

Mndandanda wa mankhwala Amoxiclav

Zofanana muzochitika zamagulu: