Movoglen® (Movogleken)

Khazikani payekhapokha kutengera chithunzithunzi cha matenda. Mlingo woyambirira wa Movoglechen ndi 2,5-5 mg 1 nthawi / tsiku 15-30 mphindi asanadye kadzutsa. Ngati ndi kotheka, mlingo umatha pang'onopang'ono (pang'onopang'ono) ndi 2,5-5 mg / tsiku. Mlingo watsiku ndi tsiku wopitilira 15 mg uyenera kugawidwa pawiri.

Mlingo waukulu wa Movoglechen: osakwatiwa - 15 mg, tsiku lililonse - 40 mg.

Zotsatira za pharmacological

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba, kumawonjezera kutulutsidwa kwa insulin. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Ili ndi hypolipidemic, fibrinolytic kwenikweni, imalepheretsa kuphatikiza kwa maselo ambiri.

Zotsatira zoyipa

Kuchokera ku dongosolo la endocrine: kawirikawiri - hypoglycemia (makamaka okalamba, odwala ofooka, osadya mosakhazikika, kumwa mowa, chiwindi ndi matenda a impso).

Kuchokera mmimba dongosolo: nseru, kutsegula m'mimba, kawirikawiri - poizoni hepatitis.

Kuchokera pa hemopoietic dongosolo: nthawi zina - thrombocytopenia, leukopenia, agranulocytosis.

Thupi lawo siligwirizana: kawirikawiri - zotupa pakhungu, kuyabwa.

Malangizo apadera

Mukamagwiritsa ntchito Movoglechen pambuyo pa insulin kapena othandizira ena a hypoglycemic, kudya mwachangu kwa Movoglechen m'magazi kuyenera kuganiziridwa ndipo masiku oyambira 4-5 mlingo uyenera kuyendetsedwa molingana ndi mbiri ya glycemic.

Ndi chitukuko cha hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena yankho la shuga) amapatsidwa mkati. Pofuna kutaya chikumbumtima, glucose wamitsempha kapena glucagon sc, intramuscularly kapena kudzera m'mitsempha amathandizira. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.

Ndi kuvulala, matenda oopsa, kulowererapo kwakukulu, wodwalayo ayenera kusamutsidwa kuti azigwiritsa ntchito insulin.

Kuchita

Movoglechen sayenera kugwiritsidwa ntchito nthawi imodzi ndi miconazole.

Ndi munthawi yomweyo kugwiritsa ntchito salicylates, sulfonamides, ACE zoletsa, mowa, kumwa kwambiri hypoglycemic angayambe. Kugwiritsa ntchito nthawi yomweyo kwa beta-blockers kungatchinjirize kuwonetsa kwa hypoglycemia.

Thiazide okodzetsa, mapuloteni opanga, GCS (kuphatikizapo ntchito yapakhungu), chlorpromazine imafooketsa zochita za Movoglechen.

Gulu la mankhwala

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chosowa Chidziwitso, ‰

Zikalata zoyendetsera za Movogleken ®

• LP-001191

Webusayiti yovomerezeka ya kampani RLS ®. Ensaikulopediya yayikulu ya mankhwala osokoneza bongo ndi katundu wa mankhwala omwe amapezeka ku Russia Internet. Ndondomeko yamankhwala Rlsnet.ru imapatsa ogwiritsa ntchito malangizo, mitengo ndi mafotokozedwe a mankhwala, zowonjezera pazakudya, zida zamankhwala, zida zamankhwala ndi zina. Maupangiri a pharmacological akuphatikiza chidziwitso cha kapangidwe ndi mawonekedwe amamasulidwe, zochitika zamankhwala, zisonyezo zogwiritsidwa ntchito, contraindication, zotsatira zoyipa, kuyanjana kwa mankhwala, njira yogwiritsira ntchito mankhwala, makampani opanga mankhwala. Ndondomeko ya mankhwala ili ndi mitengo yamankhwala ndi mankhwala ku Moscow ndi mizinda ina ya Russia.

Sizoletsedwa kufalitsa, kukopera, kufalitsa zambiri popanda chilolezo cha RLS-Patent LLC.
Mukamagwiritsa ntchito zidziwitso zofalitsidwa pamasamba a webusayiti ya www.rlsnet.ru, kulumikizana ndi gwero lachidziwitso ndikofunikira.

Zinthu zina zambiri zosangalatsa

Maumwini onse ndi otetezedwa.

Kugwiritsa ntchito malonda pazinthu sikuloledwa.

Chidziwitsochi cholinga chake ndi akatswiri azachipatala.

Kupanga Movoglechen mu mawonekedwe apiritsi

Chithandizo: glipizide - 5 mg,

zokopa: lactose 130 mg, pregelatinized wowonda 30 mg, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0,8 mg, stearic acid 1.6 mg.

mapiritsi ozungulira oyera amtundu woyera wokhala ndi "U" wozungulira mbali imodzi ndikuyika chiopsezo mbali inayo.

Pharmacodynamics wa mankhwala

Glipizide imakhala ndi pancreatic ndi extrapancreatic. Zimapangitsa secretion ya insulin pochepetsa kutsika kwa shuga wa khungu la cell wa cell wa cell, kumakulitsa chidwi cha insulin komanso kumangiriza ma cell omwe mukufuna, kumawonjezera kutulutsidwa kwa insulini, ndikuwonjezera zochita za insulin pa minofu ndi chiwindi cha glucose, ndikuletsa lipolysis mu minofu ya adipose. Kukula kwa vuto la hypoglycemic kutengera kuchuluka kwa maselo a beta. Ilinso ndi hypolipidemic, fibrinolytic kwenikweni, imalepheretsa kuphatikiza kwa maselo ambiri, ndipo imakhala yofatsa.

Pharmacokinetics

Pambuyo pakamwa, glipizide imathamanga ndipo imatsala pang'ono kulowa m'matumbo amunthu. Pazipita plasma ndende zimatheka pambuyo maola atatu mutamwa kamodzi. Kudya sikumakhudza kuyamwa kwathunthu ndi kudzikundikira kwa mankhwalawa, komabe, nthawi ya mayamwidwe imawonjezeka ndi mphindi 40. Bioavailability ndi 90%, kulumikizana ndi mapuloteni a plasma ndi 98-99%.

Zimapangidwa m'chiwindi kuti ma metabolites osagwira. Amachotseredwa ndi impso - 90% mu mawonekedwe a metabolites, 10 % - zosasinthika.

Hafu ya moyo ndi maola 2-4.

Contraindication Movoglechen mu piritsi

Hypersensitivity kuti sulfonylureas, sulfonamides,

Hypersensitivity kuti glipizide kapena mankhwala ena aliwonse

mtundu 1 shuga

matenda ashuga ketoacidosis, matenda a shuga komanso chikomokere,

zinthu zomwe zimafunikira chithandizo cha insulin (kuwotcha kwambiri, kulowererapo kwakukulu, kuvulala kwambiri ndi matenda opatsirana),

chiwindi ndi impso kwambiri.

kufupika kwa lactase, tsankho lactose, malabsorption wa glucose-galactose,

Mimba, kuyamwa.

Mlingo ndi makonzedwe a Movoglechen mu mawonekedwe apiritsi

Mlingo umatengera zaka, kuopsa kwa matenda ashuga, kuchuluka kwa shuga m'magazi pamimba yopanda kanthu komanso maola awiri atatha kudya.

Gawani mkati, mphindi 30 musanadye. Mlingo woyamba wa tsiku lililonse ndi 5 mg musanadye chakudya cham'mawa, ngati palibe zotsatira, mlingo umakulitsidwa ndi 2,5-5 mg ndikuwunika pafupipafupi kuchuluka kwa shuga.

Mu matenda a chiwindi, impso ndi okalamba odwala, koyamba tsiku lililonse mlingo ndi 2,5 mg.

Mlingo umodzi wambiri ndi 15 mg, mlingo waukulu wa tsiku lililonse ndi 40 mg. Pafupipafupi makonzedwe ndi 1 nthawi patsiku, Mlingo tsiku lililonse oposa 15 mg ayenera kugawidwa mu Mlingo wa 2-4.

Zotsatira zoyipa za mankhwalawo

Kuchokera ku endocrine system: hypoglycemia, hypoglycemic chikomokere.

Kuchokera ku dongosolo lamanjenje: chizungulire, kupweteka mutu, kugona.

Pa khungu: zotupa pakhungu ndi mucous nembanemba, kuyabwa pakhungu, urticaria, chikanga, photosensitivity.

Kuchokera ku ziwalo za hemopoietic: kuletsa mafupa hematopoiesis (kuchepa magazi, kuphatikizapo aplastic ndi hemolytic, pancytopenia, leukopenia, agranulocytosis, thrombocytopenia).

Kuchokera m'mimba: nseru, kusanza, kutsegula m'mimba kapena kudzimbidwa, kusefukira kwamadzi, jaundice ya cholestatic, kulephera kwa chiwindi, chiwindi, hephatic porphyria.

Kuchokera ku ziwalo zomverera: Kuzindikira kowoneka bwino, kuwona kwamisala.

Zizindikiro zasayansi: kuchuluka kwa aspartate aminotransferase (ACT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), kuchuluka kwatsalira wa urea nayitrogeni m'madzi a m'magazi, hypercreatininemia.

Zina: kunenepa kwambiri, myalgia, zopweteka, hyponatremia, disulfiram ngati zimachitika.

Kuchokera m'mimba: nseru, kusanza, kudzimbidwa, kutsegula m'mimba, kupweteka kwa epigastric, hepatitis.

Pa khungu: zotupa za urticaria, kuyabwa pakhungu, erythema multiforme exudative.

Kuchokera ku ziwalo za hemopoietic: kuchepa kwa magazi m'thupi, aplasic ndi hemolytic anemia, pancytopenia, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia.

Zina: Mwina chitukuko cha hyponatremia ndi kuphwanya katulutsidwe wa antidiuretic timadzi.

Bongo

Mankhwala osokoneza bongo amatha kupititsa patsogolo hypoglycemia.

Zizindikiro za hypoglycemia: njala, thukuta kwambiri, kufooka kwambiri, kunjenjemera, nkhawa, kupweteka mutu, kusowa tulo, kusakwiya, kuvutika maganizo, kusalankhula bwino ndi masomphenya, kuvutika kuganizira kwambiri, kulocha chikumbumtima.

Chithandizo: ngati wodwalayo akhudzidwa, tengani shuga kapena shuga mkati, kuti ataye matenda, kufunikira kwamkati ndikofunikira 40 % dextrose solution (glucose), ndiye - kulowetsedwa kwa 5% dextrose solution, 1-2 mg ya glucagon subcutaneally, intramuscularly kapena kudzera m'mitsempha. Pambuyo podziwikanso, ndikofunikira kuti mupatse wodwalayo chakudya chambiri m'zakudya zamafuta ochepa (kuti mupewe kukonzanso kwa hypoglycemia). Ndi matenda edema, mannitol ndi dexamethasone.

Tulutsani mawonekedwe, ma CD ndi kapangidwe kake

Mapiritsi ozungulira oyera ozungulira okhala ndi "U" wozungulira wozungulira mbali imodzi ndi chiopsezo mbali inayo.

Othandizira: lactose 130 mg, pregelatinized st 30 30, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0,8 mg, stearic acid 1.6 mg.

24 ma PC. - matuza opangidwa ndi PVC / aluminium zojambulazo (2) - mapaketi a makatoni.

Mlingo

Khazikani payekhapokha kutengera chithunzithunzi cha matenda. Mlingo woyambirira ndi 2.5-5 mg 1 nthawi / tsiku 15-30 mphindi musanadye chakudya cham'mawa. Ngati ndi kotheka, mlingo umatha pang'onopang'ono (pang'onopang'ono) ndi 2,5-5 mg / tsiku. Mlingo watsiku ndi tsiku wopitilira 15 mg uyenera kugawidwa pawiri.

Mlingo waukulu: umodzi - 15 mg, tsiku lililonse - 40 mg.

Zotsatira zoyipa

Kuchokera ku dongosolo la endocrine: kawirikawiri - hypoglycemia (makamaka okalamba, odwala ofooka, osadya mosakhazikika, kumwa mowa, chiwindi ndi matenda a impso).

Kuchokera mmimba dongosolo: nseru, kutsegula m'mimba, kawirikawiri - poizoni hepatitis.

Kuchokera pa hemopoietic dongosolo: nthawi zina - thrombocytopenia, leukopenia, agranulocytosis.

Thupi lawo siligwirizana: kawirikawiri - zotupa pakhungu, kuyabwa.

Zina: mutu.

Kuyanjana kwa mankhwala

Ndi munthawi yomweyo kugwiritsa ntchito salicylates, sulfonamides, ACE zoletsa, mowa, kumwa kwambiri hypoglycemic angayambe. Kugwiritsa ntchito nthawi yomweyo kwa beta-blockers kungatchinjirize kuwonetsa kwa hypoglycemia.

Thiazide okodzetsa, mapuloteni opanga, GCS (kuphatikizapo apakhungu ntchito), chlorpromazine imafooketsa mphamvu ya glipizide.

Mankhwala ofanana:

• Guarem (Guarem) Yolembedwa ma microbeads
• Mapiritsi a Amaryl
• Viktoza (Victoza) Yankho la jakisoni
• Metformin hydrochloride (Metformin hydrochlor> Substance-Powder
• Mapiritsi a pakamwa a Metformin-Teva (Metformin-Teva)
• Mapiritsi a Galvus Met (Galvus Met) Oral
• Januvia Oral Mapale
• Mapale a Berlithion (Berlithion) Oral
• Mapiritsi a Glucovans (Glucovance) Oral
• Mapiritsi a Langerin (Lanagerin)

** Maupangiri a Mankhwala ndi a zidziwitso zokha. Kuti mumve zambiri, chonde onani zomwe akupanga. Osadzilimbitsa, musanayambe kugwiritsa ntchito mankhwala Movogleken muyenera kufunsa dokotala. EUROLAB sikuti ali ndi vuto pazotsatira zomwe zimadza chifukwa chogwiritsa ntchito chidziwitso chomwe chatumizidwa pa tsamba. Zomwe zili patsamba lililonse sizilowa m'malo mwa upangiri waudokotala ndipo sizingakhale chitsimikizo cha mankhwala.

Kodi mumakondwera ndi Movoglecen? Kodi mukufuna kudziwa zambiri kapena muyenera kukaonana ndi dokotala? Kapena mukufuna kuyesedwa? Mutha kutero pangana ndi adokotala - Euro yachipatala labu nthawi zonse pantchito yanu! Madotolo abwino amayeserera, kukulangizani, kukupatsani chithandizo choyenera ndikupanga matenda. Mukhozanso Itanani dokotala kunyumba. Chipatala cha Euro labu tsegulani kwa inu nthawi yonse yoyandikira.

** Tcheru! Zomwe zawonetsedwa mu bukhuli zamankhwala ndizothandiza akatswiri azachipatala ndipo siziyenera kukhala chifukwa chodzidziwira nokha. Kufotokozera kwa mankhwala a Movoglecen amaperekedwa kuti amve zambiri ndipo sanapangidwe kuti adziwe chithandizo popanda kutenga nawo mbali adokotala. Odwala amafunikira upangiri waluso!

Ngati mukukondwererabe mankhwala ndi mankhwala ena aliwonse, mafotokozedwe awo ndi malangizo ogwiritsira ntchito, chidziwitso cha kapangidwe ndi mawonekedwe amamasulidwe, zikuwonetsa kugwiritsa ntchito ndi zoyipa, njira zogwiritsira ntchito, mitengo ndi kuwunika kwa mankhwala, kapena kodi muli ndi mafunso ena ndi malingaliro - tilembereni, tiyesetsa kukuthandizani.

Kugwiritsa ntchito Movoglechen pa nthawi yapakati komanso pakudya

Gawo la FDA la mwana wakhanda ndi C.

Pankhani yogwiritsa ntchito panthawi yomwe mukukhala ndi pakati, kuletsa kuvomerezedwa kumakhala kofunikira mwezi umodzi asanabadwe komwe akuyembekezeka komanso kusintha kwa insulin.

Pa nthawi ya chithandizo ayenera kusiya kuyamwitsa.

Chithandizo: kusiya kwa mankhwala osokoneza bongo, kudya glucose komanso / kapena kusintha kwa zakudya zomwe zikuyenera kuyanidwa ndi glycemia, ndi vuto lalikulu la hypoglycemia (chikomokere, khunyu) - kugonekedwa kuchipatala msanga, kutsata njira ya glucose ya 50% yokhala ndi kulowetsedwa munthawi yomweyo (iv. Drip) % yankho la glucose kutsimikizira kuchuluka kwa shuga m'magazi pamwamba pa 5.5 mmol / L, kuwunika glycemia ndikofunikira pakatha masiku 1-2 wodwala atachoka. Kutsegula m'mimba sikothandiza.

Maminolo ndi glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), katsitsumzukwa, baclofen, calcium antagonists, carbonic anhydrase inhibitors (epetepholamide), chlortalidone, njira yolerera pakamwa, epinephrine, ethacinic acid, giurimide, thymoside gland, triamteren ndi mankhwala ena omwe amayambitsa hyperglycemia. Anabolic steroids ndi androgens amalimbikitsa ntchito za hypoglycemic. Ma anticoagulants osadziwika, NSAIDs, chloramphenicol, clofibrate, guanethidine, Mao inhibitors, probenecid, sulfonamides, rifampicin kuwonjezera kuchuluka kwa gawo lamagazi m'magazi (chifukwa chakuchotsa mapuloteni a plasma) ndikuwonjezera mapangidwe a biotransfform. Ketonazole, miconazole, sulfinpyrazone block inactivation ndikuwonjezera hypoglycemia. Poyerekeza ndi zakumwa zoledzeretsa, kukulira kwa disulfiram-like syndrome (kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu) ndikotheka. Mankhwala a Antithyroid ndi myelotoxic amawonjezera mwayi wokhala ndi agranulocytosis, wotsiriza, kuwonjezera - thrombocytopenia.

Kwa pang'onopang'ono mawonekedwe a glipizide:

Kuchokera kwamankhwala amanjenje ndi ziwalo zam'maganizo: chizungulire, kupweteka mutu, kugona tulo, kuda nkhawa, kukhumudwa, kusokonezeka, kusokonezeka kwa mitsempha, paresthesia, Hypersthesia, kuphimba pamaso, kupweteka kwamaso, conjunctivitis, zotupa za m'mimba.

Kuchokera kumbali ya mtima ndi magazi (hematopoiesis, hemostasis): syncope, arrhythmia, ochepa matenda oopsa, kumva kutentha kwamphamvu.

Kuchokera kumbali ya kagayidwe: hypoglycemia.

Kuchokera mmimba thirakiti: anorexia, nseru, kusanza, kumva kupsinjika mu epigastric dera, dyspepsia, kudzimbidwa, kusakanikirana kwa magazi mu chopondapo.

Kuchokera pakhungu: zotupa, urticaria, kuyabwa.

Kuchokera pakapumidwe: Rhinitis, pharyngitis, dyspnea.

Kuchokera ku genitourinary system: dysuria, yafupika libido.

Zina: ludzu, kunjenjemera, zotumphukira edema, kupweteka kwakanthawi mkati mthupi lonse, arthralgia, myalgia, kukokana, thukuta.

Mtundu wa glipizide:

Kuchokera kwamanjenje ndi ziwalo zam'maganizo: mutu, chizungulire, kugona.

Kuchokera pamtima ndi magazi a mtima (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic kapena aplastic anemia.

Kuchokera kumbali ya kagayidwe: shuga insipidus, hyponatremia, matenda a porphyrin.

Kuchokera mmimba thirakiti: nseru, kusanza, kupweteka kwa epigastric dera, kudzimbidwa, cholestatic hepatitis (chikasu madontho a khungu ndi sclera, kusungunuka kwa chopondapo ndi kuziziratu kwamkodzo, kupweteka mu hypochondrium yoyenera).

Kuchokera pakhungu: erythema, maculopapular totupa, urticaria, photosensitivity.

Zina: kuchuluka kwa LDH, alkaline phosphatase, bilirubin wosalunjika.

Matenda am'mimba, chiwindi ndi impso (zimafunikira kuwunika kwamisempha wamagazi), zaka za ana (mphamvu ndi chitetezo cha ana sizinakhazikitsidwe).

Hypersensitivity, matenda ashuga ketoacidosis, matenda ashuga, ana aang'ono mtundu 1 matenda osokoneza bongo, kutentha thupi, kuvulala, kuchitira opareshoni, kutenga pakati, kuyamwitsa.

Type 2 shuga mellitus posakhalitsa mphamvu yotsika kalori chakudya, zolimbitsa thupi, etc., matenda ashuga.

Zotsatira zam'magazi ndi hypoglycemic. Imalimbikitsa kutulutsa kwa insulin kuchokera ku ma cell a yogwira pancreatic beta. Amachepetsa kuchuluka kwa hemoglobin ya glycosylated komanso kusala kudya kwa glucose mwa odwala omwe ali ndi mitundu iwiri komanso yolimba ya matenda a shuga. Amachepetsa pambuyo pa chakudya hyperglycemia, kumawonjezera kulolerana kwa glucose ndikumasulidwa kwamadzimadzi kwaulere (mpaka pang'ono). Kuyankha kwa insulinotropic kumayamba pakapita mphindi 30 kuchokera pakamwa, kutalika kwa nthawi limodzi ndi limodzi kumafikira maola 24. Sikuwakhudza ma lipid mawonekedwe am'magazi.

Poyeserera makoswe ndi mbewa zapamwamba nthawi 75 kuposa MPD, sizilimbikitsa carcinogeneis ndipo sizikhudza chonde (makoswe). Kafukufuku wochitidwa pa bacteria ndi vivo sanawonetse katundu wa mutagenic.

Fomu yochita zinthu mwachangu imalowetsedwa mwachangu komanso mokwanira. Kudya sikukhudza mayamwidwe athunthu, koma kumachepetsa kwa mphindi 40. Cmax imatsimikiziridwa pambuyo pake patatha maola 1-3. T1 / 2 ndi maola 2 - 4 4. Atatenga mawonekedwe ochepetsetsa, amawonekera m'magazi pambuyo pa maola 2-3, Cmax imafikiridwa pambuyo pa maola 6 mpaka 6. Amaphatikizidwa ndi mapuloteni am'madzi ndi 98-99%. Kuchuluka kwa ma iv pambuyo pa maulamuliro a 11 ndi 11 l, pafupifupi T1 / 2 ndi maola 2-5. Biotransformed mu chiwindi (ndi gawo loyambirira - pang'ono). Zosakwana 10% zimachotsedwa mu mkodzo ndi ndowe, pafupifupi 90% zimachotsedwa mu mawonekedwe a metabolites ndi mkodzo (80%) ndi ndowe (10%).

Poda yoyera yopanda mafuta. Osalowa mumadzi ndi mowa, koma sungunuka mu yankho la 0,1 mol / L NaOH komanso sungunuka kwambiri mu dimethylformamide.

N-2-4- (Cyclohexylamino) carbonylamino sulfonylphenylethyl-5-methylpyrazine carboxamide