Liraglutide ndi kunenepa kwambiri - chifukwa chiyani mankhwalawa ali oyenera pochizira matenda am'thupi?

Mankhwalawa akupezeka pansi pa mayina amalonda Viktoza ndi Saksenda. Ndi njira yodziwikiratu, yopanda utoto kwa makina amtundu wanthawi zonse. Madziwo amagulitsidwa m'makapu a magalasi, osindikizidwa mumapulasitiki omwe ali ndi mitundu yambiri ya jakisoni kuti apange jakisoni wobwereza ndikuyika makatoni.

Saxenda ndi Viktoza ali ndi mawonekedwe ofanana. Chosakaniza chophatikizacho ndi liraglutide, ndipo zina zowonjezera ndi sodium hydrogen phosphate dihydrate, hydrochloric acid / sodium hydroxide, phenol, madzi a jekeseni, propylene glycol.

Zotsatira za pharmacological

Zomwe zimagwiritsidwa ntchito ndi mankhwala ndi kapangidwe kakang'ono ka glucagon-peptide-1. GLP-1 yopangidwa mwanjira yachilendo imakhala yodziwika kuyambira koyambirira (kufanana kwake ndi 97%), kotero thupi silikuwona kusiyana pakati pawo. Ndi subcutaneous makonzedwe, liraglutide imamangiriza kwa ma receptors, imayambitsa kupanga glucagon ndi insulin. Popita nthawi, insulini imayamba kupangidwa yokha, zomwe zimapangitsa kuti magazi achulukane.

Kupanga kwa chinthu cha zinthu kungafotokozeredwe motere:

1. Chiwerengero cha ma peptides chikuchulukirachulukira.
2. Ntchito ya kapamba imayenda bwino, magazi a m'magazi amatsika kukhala abwinobwino.
3. Michere yomwe imalowa mthupi kudzera mu chakudya imalowetsedwa mokwanira.
4. Chizindikiro cha machulukitsidwe amalowa mu ubongo.
5. Kulakalaka kumachepa, kuchepa thupi kumachitika.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amaperekedwa kwa odwala akuluakulu omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo kuti abwezeretse index ya glycemic ndikuchepa. Zitha kugwiritsidwa ntchito ngati othandizira pawokha komanso ngati gawo la mankhwala ophatikiza (ndi metformin, insulin, thiazolidinediones, sulfonylurea zotumphukira).

Ngati wodwala matenda ashuga ali ndi matenda amtima, liraglutide imagwiritsidwa ntchito ngati gawo la zovuta kuchizira kuchepetsa chiopsezo cha stroke, myocardial infarction, ndi kufa.

Malangizo ogwiritsira ntchito mankhwalawa

Kuchiza kunenepa, Saksenda imagwiritsidwa ntchito - yankho la subcutaneous makonzedwe. Mankhwalawa amagulitsidwa m'njira yokhala ndi cholembera yokhala ndi sikelo yodziwira mulingo wofuna. Mutha kupaka jakisoni m'mawa, masana kapena madzulo, osasamala chakudyacho. Madokotala amalimbikitsa kuperekera mankhwalawa nthawi yomweyo kuwonetsetsa kuti pakati pakubwera jekeseni.

Dongosolo la makonzedwe a mankhwalawa ndi motere:

1. Singano imayikidwa pansi pa khungu malinga ndi malingaliro omwe adalandira kuchokera kwa namwino kapena dokotala. Syringe imachitika kotero kuti wotsutsana ndi mlingo wayandikira.
2. Dinani batani limakankhidwa njira yonse ndikugwira mpaka chithunzi 0 chikuwonetsedwa kutsogolo kwa chisonyezo.
3. Gwirani singano pansi pa khungu ndikuwerengera pang'onopang'ono mpaka 6.
4. Chotsani singano. Magazi akawoneka, swab wosalala wosindikizira amakanikizidwa kumalo opaka jekeseni.

Njira yothetsera vutoli iyenera kuperekedwa nthawi 1 patsiku, phewa kapena pamimba. Mlingo wa tsiku ndi tsiku umatengera nthawi yomwe mankhwalawa agwiritsidwa ntchito:

• Sabata 1 - 0,6 mg
• Masabata awiri - 1,2 mg,
• Masabata atatu - 1,8 mg,
• Masabata 4 - 2.4 mg,
• Sabata 5 komanso wotsatira - 3 mg.

Kukhazikitsa zoposa 3 mg ya mankhwala patsiku ndizoletsedwa, chifukwa izi zimatha kuyambitsa kukula kwa bongo.

Kodi liraglutide imakhala yothandiza motani?

Jekeseni wa liraglutide amachepetsa kugaya, komwe kumapangitsa kuchepa kwa chakudya komanso kuchepa kwa chakudya cha tsiku ndi tsiku cha 15 caloric. Izi zikulongosola zaukali kwambiri wa chinthucho komanso kuchuluka kwa ndemanga zabwino za izi.

Kuti muchepetse thupi, jakisoni yekha siokwanira. Nutritionists amalimbikitsa kugwiritsa ntchito jakisoni kuphatikiza njira zina ndi njira zochepetsera thupi. Malangizo otsatirawa athandiza kufulumizitsa njirayi:

1. Zakudya zoyenera. Kuti muchepetse kunenepa, ndikofunikira kuchepetsa calorie kudya tsiku lililonse. Kuti muchite izi, siyani ufa ndi zotakata, zakudya zamafuta ndi okazinga. Akatswiri ena azakudya amalimbikitsa kudya zakudya zazing'ono kangapo kamodzi pa 6 patsiku, koma endocrinologists amati kudya kotereku kumatha kuyambitsa insulin kukana.
2. Zochita zolimbitsa thupi. Kuyenda mlengalenga, kuthamanga, masewera olimbitsa thupi, kusambira ndi zina zolimbitsa thupi kumathandizira kuonjezera kudya kwa calorie.
3. Kutsatira Mlingo woyenera ndi dokotala. Njira yothetsera vutoli iyenera kugwiritsidwa ntchito pa 3 mg patsiku (kupatula masabata 4 oyambilira, pamene kuchuluka kwawonjezeka pang'onopang'ono).

Anthu opitilira 80% omwe amatenga liraglutide kuti achepetse thupi ali ndi mayendedwe abwino. Kusintha 20% yotsala sikumawonedwa.

Kuyanjana kwa mankhwala

Pa mankhwala, kutsuka kwa m'mimba kumachedwetsedwa, komwe kumakhudza molakwika kuchuluka kwa mayamwidwe ena a mankhwalawa. Kuyanjana kotere sikunafotokozeredwe bwino, kotero kusintha kusintha kwa mankhwala sikofunikira.

Kuphatikiza yankho ndi mankhwala ena sikuletsedwa, chifukwa izi ndizovuta ndi kuwonongedwa kwa gawo lomwe limagwiritsa ntchito mankhwalawa.

Liraglutide ingagwiritsidwe ntchito nthawi imodzi ndi thiazolidinedione ndi metformin monga gawo la zovuta mankhwala.

Contraindication

Zoyipa zogwiritsidwa ntchito pazinthu zimagawidwa kukhala mtheradi ndi wachibale. Ndi zoletsedwa kupereka jakisoni pamaso pa zinthu zotsatirazi ndi matenda:

• kusalolera payekhapayekha ndi magawo ena a yankho,
• mtundu 1 shuga
• kulephera kwa mtima (mitundu 3 ndi 4),
• khansa ya chithokomiro
• kuwonongeka kwambiri kwa aimpso kapena kwa chiwindi ntchito,
• angapo endocrine neoplasia syndrome,
• kutupa matumbo
• nthawi yoyamwitsa, pakati.

• kapamba (chitetezo cha zinthu mwa odwala omwe ali ndi vutoli sichinaphunzire),
• ukalamba (woposa zaka 75),
• munthawi yomweyo kugwiritsa ntchito jakisoni wa insulin ndi agonists ena a GLP-1,
• matenda amtima
• kugwiritsa ntchito mapiritsi ena ndi njira zothetsera kuwonda.

Sitikulimbikitsidwanso kupereka jakisoni muubwana ndi unyamata, chifukwa momwe thupi limagwirira zinthu zovulazidwa zimatha kukhala zosayembekezereka. Dokotala yekha ndi amene angamwe mankhwala kwa odwala omwe ali ndi zaka 18, kuonetsetsa kuti pali zisonyezo komanso palibe zotsutsana.

Zotsatira zoyipa

Nthawi zambiri, odwala omwe amagwiritsa ntchito liraglutide samakumana ndi mavuto am'mimba:

• 40% ya milandu - nseru (nthawi zina zimatsatiridwa ndi kusanza),
• mu 5% ya milandu - zovuta zakudziyimira (kudzimbidwa, kutsegula m'mimba).

Kusamalidwa makamaka kuyenera kuthandizidwa ndi anthu omwe ali ndi matenda ashuga a 2. Mwa odwala atatu mwa 100, chithandizo chambiri chomwe chili ndi liraglutide chimatsogolera pakukula kwa hypoglycemia.

Zotsatira zina zoyipa zomwe zimachitika pakumwa mankhwalawa ndi monga zotsatirazi:

• mutu
• kuchuluka kwa mpweya,
• kufooka, kutopa,
• thupi lawo siligwirizana (kuphatikiza pozungulira jakisoni),
• matenda a chapamwamba kupuma thirakiti,
• kuchuluka kwa mtima - kugunda kwa mtima.

Zotsatira zoyipa zambiri zimawonedwa pakadutsa masiku 7 mpaka 14 kuyambira chiyambi cha mankhwala. Popita nthawi, thupi limazolowera mankhwalawa, ndipo zotsatira zoyipa zimachepa. Ngati izi sizichitika mwa iwo okha kapena kukulitsa, muyenera kufunsa dokotala.

Mtengo wa mankhwala

Mtengo wa liraglutide muma pharmacies umatengera dzina lazamalonda ndi zomwe wagawana:

• Wopweteka, 6 mg / ml, 3 ml, 2 ma PC. - kuchokera 9500 rub.,
• Victoza, 18 mg / 3 ml, 2 ma PC. - kuchokera 9000 rub.,
• Saxenda, 6 mg / ml, 3 ml, 5 ma PC. - kuchokera 27000 rub.

Ngati kugwiritsa ntchito mankhwala a Saxend ndi Viktoz sikutheka, muyenera kufunsa dokotala kuti musankhe mankhwala omwe ali ndi vuto lofananalo. Chimodzi mwazomwe mungagwiritse ntchito kukhala mankhwala:

1. Novonorm (mapiritsi). Amalembera odwala omwe ali ndi matenda a shuga 2. Kugwiritsa ntchito kuchepetsa magazi. Ndi analogue yotsika mtengo kwambiri (ma CD okwanira 150-250 rubles).
2. Liksumiya (yankho la sc management). Amachepetsa shuga la magazi mosasamala nthawi yakudya. Zimawononga ma ruble 2500-7000.
3. Forsiga (mapiritsi). Zimathandizira kuchepetsa kukweza kwa glucose komanso kutsitsa shuga pambuyo pudya. Mtengo wa 1 syringe ndi 1800-2800 rubles.
4. Byeta. Woimira amino acid amidopeptides. Kuchepetsa m'mimba, kutsokomola, kumayamba kuchepa thupi. Ndi analogue yodula kwambiri (1 syringe imakhala pafupifupi ma ruble 10,000.).

Ndi dokotala yekhayo amene angakupatseni mankhwala ofanana. Kusankha kwayekha kwa othandizira a hypoglycemic kumakhala kofupika chifukwa chosagwiritsa ntchito mankhwalawa ndikukula kwa mayankho osayenera kuchokera m'matumbo am'mimba komanso machitidwe ena a thupi.

Inga, wazaka 45, Moscow: "Ndinapeza matenda a shuga zaka 5 zapitazo. Sindinakhalepo woonda, koma m'zaka zaposachedwa, kunenepa kwambiri kwakhala kovuta. Ndidayesera kuchepa thupi kudzera pamasewera komanso kudya mokwanira, koma ndidalephera. Dotolo adalangiza kugula mankhwala a Saksenda mwanjira yothetsera vutoli ndikuwonetsa momwe amapangira jakisoni moyenera. Poyamba zinali zowopsa komanso zopanda nkhawa, koma pambuyo pake zidazolowera. Munthawi yamankhwala, ndinatha kutsika makilogalamu anayi, ndipitilizabe kuchepa thupi tsopano. ”

Kirill, wazaka 51, St. Petersburg: "Sindingathe kuchepetsa thupi mpaka nditapita kukadyetsa zakudya. Sindinapeze cholakwika chilichonse chogwiritsa ntchito Liraglutide, motero adotolo adandiwuza kuti ndipange jakisoni. Kumapeto kwa maphunzirowo, adayamba kuchita zopukutira kuti aphatikize zotsatira zake. Kulemera sikukuonekabe. "

Larisa, wazaka 42, Samara: “Ndidayesera zakudya zambiri kuti ndichepe thupi, koma palibe amene adandithandiza. Ndinaganiza zoyamba kugwiritsa ntchito mankhwala osokoneza bongo ndipo ndinatembenukira kwa endocrinologist, yemwe adalemba jakisoni wa mankhwala Saksenda. Kwa miyezi ingapo kunali kotheka kutaya 5 kg, koma njira yochepetsera thupi ikupitilizabe mpaka pano. Ndikufuna ndichenjeze anthu omwe amamwa mankhwalawa: palibe chomwe chingagwire ntchito popanda masewera komanso zakudya zoyenera, chifukwa chake yesetsani kukhala ndi moyo wathanzi mukamalandira chithandizo. ”

Zizindikiro ndi mphamvu

Thupi lomwe limatchulidwira mankhwala ngati liraglutide ndi analogue yochita kupanga ya mahomoni opangidwa ndi maselo am'mimba - glucagon-ngati peptide-1 (GLP-1). Chifukwa cha kupukusa kwa izi, kumapangika njira yothandiza, yomwe imapewa kudya kwambiri komanso kulemera kwotsatira. Mwanjira ina, GLP-1 ndi yowongolera yachilengedwe ya kudya ndi kudya.

Liraglutide yochulukirapo imagwiritsidwa ntchito ngati njira ya Saxenda ndi Victoza. Kampaniyo Novo Nordisk (Denmark) ikugwira nawo ntchito yopanga. Mankhwala amapezeka mu mawonekedwe a cholembera chodzaza ndi yankho lomwe limapangidwa kuti likhale loti lizigwiritsa ntchito poyambira.

Zochita zikuwonetsa kuti kugwiritsa ntchito moyenera mankhwala omwe ali ndi liraglutide, ndizotheka kukwaniritsa kuchepetsa kwambiri thupi.

Amalembedwa kwa odwala omwe ali ndi:

• Type 2 shuga, yomwe imayendera limodzi ndi kunenepa kwambiri,
• BMI pamwambapa 30 yopanda matenda,
• BMI ya 27, pamene zotupa zina za m'magazi zimachitika pakukula kwa thupi (mwachitsanzo, kuthamanga kwa magazi kapena cholesterol),
• ziphuphu, zomwe zimalumikizidwa ndikuwoneka ngati mapaundi owonjezera,
• matenda a glycemic index.

Matenda ndi matenda

Pokhala cholembedwa cha glucagon chopangidwa ndi anthu monga peptide-1 (97%), liraglutide imathandizira kukhazikitsa insulin, yomwe pambuyo pake imapangitsa matenda a shuga. Thupi limakhala ndi mphamvu yokhalitsa, yomwe, makamaka, ndizotsatira zake zapamwamba za kukhazikika kwa enzymatic.

Chifukwa cha liraglutide, zingapo zofunika zimachitika:

• maselo a pancreatic beta omwe amakhudzidwa pakupanga insulin
• Kutulutsa shuga kwambiri kumalepheretsa.

Ngati shuga wamagazi akwera, liraglutide imapangitsa kuti insulin itulutse ndipo imalepheretsa kupanga shuga. Ndi hypoglycemia, zotsatira za ma analogue opanga a GLP-1 cholinga chake ndikuchepetsa kutulutsa kwa insulin.

Kuchotsa kudzikundikira kwa mafuta ochulukirapo pamene mukutenga liraglutide kumachitika ndikuchepetsa njala ndikutumiza chizindikiritso ku ubongo chokhudza kukwera mwachangu, pomwe thupi limakwaniritsa mokwanira michere yomwe idabwera ndi chakudya.

Zotsatira za liraglutide pathupi

Liraglutide ndi glucagon-peptide-1 (GLP-1) wopangidwa mwaluso. Kope la 97% limafanana ndi mahomoni achilengedwe mu kapangidwe kake.

Zochita mu thupi pambuyo makonzedwe:

• amatsitsa shuga
• imathandizira kupanga ma peptides, glucagon ndi insulin,
• zimathandizira kukhathamiritsa kwa michere mokwanira,
• ubongo umalandira chidziwitso chodzala,
• kulakalaka kumachepa.

Chifukwa cha kuyambitsidwa kwa liraglutide, masinthidwe achilengedwe opanga insulini amapangidwa modabwitsa. Ntchito za kapamba zimabwezeretsedwa, kuchuluka kwa metabolic kumachepa, ndipo kusowa kwa chakudya kumachepa.

Kuphwanya kwakukulu

Wothandizirayi wa hypoglycemic sadziwika chifukwa chakuchepetsa mafuta ochulukirapo. Pali ma contraindication angapo omwe amayenera kulingaliridwa musanayambe mankhwala.

Mndandanda wawo waperekedwa:

• mtundu 1 shuga
• matenda owopsa aimpso ndi kwa chiwindi,
• kulephera kwamtima kwa mitundu itatu,
• kutupa matumbo
• matenda ashuga ketoacidosis,
• paresis am'mimba
• zotupa za chithokomiro,
• Hypersensitivity pamagawo a mankhwala.

Liraglutide ndi yoletsedwa kugwiritsidwa ntchito mpaka zaka 18 ndi pambuyo pa 75, komanso panthawi ya pakati komanso poyamwitsa.

Zotsatira zoyipa

Nthawi zambiri, jakisoni wa mankhwalawa amayambitsa zovuta zina zakumimba. Odwala amadwala mseru, kusanza, kukhumudwa, komwe nthawi zambiri kumapangitsa kukana kugwiritsa ntchito Liraglutida.

Mndandanda wazotsatira zoyenera uyenera kuthandizidwa:

• matenda a ndulu
• kapamba
• tachycardia
• chapamwamba kupuma thirakiti matenda
• mutu
• kutopa,
• thupi lawo siligwirizana.

Malinga ndi madotolo, Zizindikiro zoyipa zilipo pakatha masabata awiri oyambilira atangoyamba kumene, pambuyo pake zimayamba kufooka ndikutha.

Kugwira ntchito kwa liraglutide kwa kuwonda

Zotsatira zakuchepa thupi pakulandila zimawonedwa ndi 80% ya odwala omwe adatenga Victoza kwa matenda a shuga. Mukamagwiritsa ntchito liraglutide, kuchuluka kwa chakudya kumachepetsedwa. Njala yotsekedwa, chilakolako cha chakudya chimasinthidwa ndipo kuchuluka kwa zakudya zomwe zimadyedwa kumachepa. Ntchito zimachepera 20%.

Kuti mudziwe momwe Viktoza amathandizira kuti muchepetse kunenepa, zotsatira za mankhwalawo zidamuyesedwa. Kuyesaku kunakhudza odzipereka a 564. Odwala adagawika m'magulu atatu. Onse ankatsatira zakudya zochepa zama calori ndipo amaphunzitsidwa tsiku ndi tsiku. M'malo mwa Victoza, gulu loyamba lidabayidwa ndi placebo. Xenical, mankhwala ochepetsa thupi okhala ndi mafuta owotcha mafuta, adapatsidwa odzipereka a gulu lachiwiri. Odwala a gulu lachitatu pamkhalidwe womwewo adapanga jakisoni wa Viktoza.

Iwo adatsimikizira kuti zotsatira zabwino zidapezeka ndi odzipereka a gulu lachitatu. Chiwerengero cha omwe adachepetsa thupi ndi 75% poyerekeza ndi 30% ndi 45% yamagulu otsalira.

Kuphatikiza apo, zinali zotheka kukhazikitsa kuti pakukhazikika kwa kuwonda, mlingo woyenera uyenera kukhala osachepera 3 mg wa chinthu chomwe chikugwira.

Adazindikiranso kuti kuti achepetse thupi, mankhwala okha siokwanira. Kuchita zinthu zovuta kumathandizira kuchepetsa kunenepa: Zakudya zochepa zopatsa mphamvu, zolimbitsa thupi ndi kugwiritsa ntchito Victoza.Ndikulimbikitsidwa mukamagwiritsa ntchito mankhwalawa kuti musiye kusuta fodya komanso kumwa mowa.

Fomu yotulutsa katundu

Palibe mapiritsi azakudya omwe ali ndi liraglutide, mankhwala amapezeka mu mawonekedwe a jakisoni. Pazinthu zovuta kuti muchepetse thupi, mankhwalawa amatumikiridwa mosiyanasiyana.

Amagula mankhwala osokoneza bongo omwe amakhala ndi syringes ya insulin. Syringe iliyonse imakhala ndi gawo logawikana, chifukwa chomwe mankhwalawo amachokera. Njira yothetsera syringe imodzi ndi yokwanira jakisoni 10-30. Mutha kuyikamo jakisoni wochepetsetsa, chifukwa ndizosavuta: ntchafu, pamimba kapena phewa.

Monga gawo la chinthu chotsika:

• liraglutide - yogwira pophika, 6 mg,
• propylene glycol - 14 mg,
• sodium hydrogen phosphate dihydrate - 1.42 mg,
• phenol - 5.5 mg
• sodium hydroxide - mpaka 1 ml,
• hydrochloric acid - 1 ml,
• madzi a jakisoni.

Zithandizo zonse ziwiri zimapezeka kuzipatala zomwe amalembera. Victoza ingagulidwe kwa ma ruble 9000-10000:

• Yankho la subcutaneous makonzedwe mu ampoules, 6 mg / ml,
• Cholembera mu katiriji mu mulingo womwewo,
• Syringe cholembera popanda cartridge - 18 mg / 3 ml.

Saxenda imagula ma ruble 27,000 osachepera. Phukusi la ma syringe asanu ndi cartridge ya 3 ml, komanso 6 mg / ml. Saxenda, yomwe imagulitsidwa ku Russia, imapangidwanso ndi kampani yaku Danish.

Kusiyana pakati pa Saksenda ndi Viktoza

1. Saxenda yokhala ndi liraglutide idapangidwa kuti muchepetse kunenepa. Victoza poyambirira adapangidwa kuti achepetse shuga.
2. Pali mankhwala ena mu syringe ya Saxend kuposa syringe ndi Viktoza.
3. Mukamagwiritsa ntchito Saxenda pakuchepetsa thupi, mavuto amayamba kuchepa pafupipafupi.

Malangizo ogwiritsira ntchito ndi liraglutide

Pambuyo poti mwagula, ma phukusi amayikidwa pomwepo mufiriji, pashelufu. Mukazizira kapena mutawotcha pamwambapa + 25 ° C, mphamvu zamafuta sizisungidwa. Kutalika kwa miyezi 30 kuyambira tsiku lomwe watulutsa.

Kugwiritsa ntchito kumatheka ngati gawo la zovuta mankhwala komanso ngati osiyana mankhwala. Mukamagwiritsa ntchito, zovuta zina nthawi zina zimachitika.

Malangizo ogwiritsira ntchito amaphatikizidwa ndi onse mankhwala omwe ali ndi liraglutide. Muli malingaliro oyendetsera. Ngati palibe malangizo apadera, amatumizidwa molingana ndi chiwembu chotsatira, mosasamala mtundu wa kumasulidwa.

Kuwerengera kwa mlingo woperekedwa kumachitika malinga ndi zomwe zimagwira.

1. Pakadutsa masiku 7 kuyambira pa chiyambi cha chithandizo, 3 mg tsiku lililonse. Mlingo umodzi umawerengeredwa potengera momwe wodwalayo alili. Mlingo woyambira woyamba ndi 1.8 mg.
2. Kuyambira masabata awiri, mlingo umakulitsidwa ndi 0,6 mg ndikuwonjezeredwa masiku 7 aliwonse.
3. Kutsika kumapangikiranso pang'onopang'ono, kuyambira milungu isanu.
4. Pakutha kwa maphunzirowa, mlingo wa tsiku ndi tsiku umakhalanso 3 mg.
5. Ngati mwaphonya jakisoni pazifukwa zilizonse, mutha kulowa mankhwalawa mkati mwa maola 12. Kuchedwa kopitilira theka la tsiku, jakisoni akusowa.

Zingwe ndizoyimira pawokha pazakudya kapena boma logwira ntchito, komabe ndikofunikira kuzichita nthawi yomweyo. Kuchulukana kwa jakisoni - katatu pa tsiku.

Kuti mugwiritse ntchito mosavuta, zoopsa zimagwiritsidwa ntchito ndi ma syringes, zomwe zimagwirizana ndi kuchuluka kwa 0.6 mg - kuyambira 0,6 mpaka 3 mg, ndiye, 0.6, 1.2, 2.4, ndi zina zambiri. Kutalika kwa mankhwalawa ndi kumwa kumatsimikiziridwa payekhapayekha, njira yocheperako ndi miyezi 4, kupitilira kwake ndi miyezi 12.

Sizotheka kuti muchepetse thupi jakisoni yomweyo ndi liraglutide. Kuchepetsa thupi kumachepetsedwa pogwiritsa ntchito njira zovuta, kuphatikiza zakudya zochepa zopatsa mphamvu, kuchita masewera olimbitsa thupi komanso kugwiritsa ntchito mankhwala ena omwe amathandizira njira ya metabolic. Mankhwala omwe amalimbikitsa mphamvu ya jakisoni amasankhidwa ndi adokotala, poganizira anamnesis.

Momwe mungasungire cholembera

Musanagwiritse ntchito:

1. Onetsetsani kuti nthawi yakwanira.
2. Dziwani momwe mankhwalawo alili. Ngati yankho lake ndi mitambo kapena kuti litangotuluka, jakisoni watayika.
3. Chotsani chomata kuchotsekera mu singano yotaya.
4. Ikani singano mwamphamvu pa syringe, chotsani chida chakunja, ndikuchiyika kotero kuti chitha kugwiritsidwanso ntchito.
5. Chipewa chamkati chimatayidwa.
6. Kanikizani mopepuka pa plunger ya syringe kufinya dontho limodzi la yankho. Ngati piston sagwira ntchito, yankho lake silituluka, syringe imatayidwa.

Akabailidwa, khungu silikhudzidwa ndi zala kuti matenda asatengeke. Mankhwalawa amaperekedwa pang'onopang'ono kuti woperekera mafuta asayenda kwambiri. Mlingo wofunikawo utalowa pansi pakhungu, singano samatulutsa mwachangu kuti mankhwalawo asatayike. Ndikulimbikitsidwa kuwerengera mpaka 6 ndikuchotsa singano yokha. Swab ya thonje imakanikizidwa kumalo opangira jakisoni, khungu silimasenda.

Musanachotsere syringe ndi yankho la jakisoni wotsatira, singano yomwe imagwiritsidwa ntchito imayikidwa mu kapu yoteteza. Mlandu umayikidwa syringe, yomwe imateteza yankho ku kuwala.

Analogs a liraglutide a kuwonda

Analogs a mankhwala oyamba akugwira ntchito:

1. Novonorm, mapiritsi, ma ruble 160. Zochitazi ndi zofanana, koma kugwiritsa ntchito sikophweka. Pafupipafupi makonzedwe 4 pa tsiku muyezo Mlingo wofanana. Mlingo wa tsiku ndi tsiku ndi 16 mg, mapiritsi amatengedwa musanadye.
2. Diaglinid, ma ruble 200. Kulandila kumayamba ndi mlingo wa 0,5 mg, kenako pang'onopang'ono muwonjezere mpaka 12 mg mu 3 waukulu.
3. Orsoten, ma ruble 600. Malangizo ogwiritsira ntchito - mphindi 30 musanadye kapena 45-60 Mphindi mutatha. Amapezeka m'mapiritsi osawoneka, kuchuluka kwa zinthu zogwira ntchito mu 12 mg iliyonse. Imwani kamodzi patsiku.
4. Reduxin, mankhwala odziwika kwambiri, 1600 rubles. Kutalika kwa njira ya mankhwalawa ndiku kuyambira miyezi itatu mpaka zaka ziwiri, tsiku lililonse 10 mg, kumasulidwa - makapisozi.
5. Forsyga, mtengo wa ma ruble 2400. Malangizo ogwiritsira ntchito ali ofanana ndi Reduxin.
6. Baeta mu cholembera. Kugwiritsidwa ntchito kuchepetsa nkhawa, kumachepetsa kuchuluka kwa peristalsis. Mtengo wa ma ruble 10,000.
7. Liksumia - ma ruble 2500-7000. Amachepetsa shuga ya magazi, mosasamala kanthu za kudya.

Musanasankhe analogue, ndibwino kufunsa dokotala. Contraindication yogwiritsira ntchito ndi zomwe zimakhudza thupi la mitundu mitundu. Kugwiritsa ntchito osaphunzira kumawononga thanzi.

Kodi analogue ya liraglutide ndiyabwino?

Odwala ambiri sangathe kugula mankhwalawo chifukwa cha mtengo wake wokwera. Chofunikanso kwambiri ndi mndandanda waukulu wazotsatira zoyipa. M'malo mobaya jiraglutide, mutha kugwiritsa ntchito mapiritsi okhala ndi ndalama zambiri pamitundu ingapo. Chachikulu ndichakuti ochiritsira kunenepa ayenera kusankhidwa ndi katswiri.

Analogue iliyonse ilinso ndi contraindication, chifukwa chake ndi bwino kupewa kupatula kugwiritsa ntchito ndalama mwanzeru.

Ndemanga ya kuchepetsa thupi za mankhwala

Odwala omwe ali ndi vuto la kunenepa kwambiri amalankhula mosiyanasiyana za Lyraglutide. Kumbali imodzi, mankhwala amatha kuthandizira kuthana ndi chidzalo, pomwe amathandizanso shuga.

Koma nthawi imodzimodzi, mankhwalawa nthawi zambiri amayambitsa zovuta zosasangalatsa mu mawonekedwe a mseru ndi kusanza, zomwe nthawi zambiri zimakhala zovuta kulekerera. Kuphatikiza apo, odwala amati mtengo wabwino ndizovuta za othandizira a hypoglycemic, chomwe ndi chimodzi mwa zifukwa zazikulu zokanira kubayidwa.

Palibe contraindication, dokotala atha kulangiza chithandizo chamankhwala ndi Lyraglutide, momwe zingathekere kuchepetsa kunenepa kwambiri kwa thupi komanso kuchepetsa matenda a shuga. Kuti mukwaniritse zomwe mukufuna, ndikofunikira kugwiritsa ntchito bwino mankhwalawa, kuwonjezera mankhwala othandizira pakudya ndi masewera olimbitsa thupi.