Insuman Bazal GT

Dzina lamankhwala	Wopanga dziko	Zogwira pophika (INN)
Insuran Nph	Russia	Insulin Yaumunthu, Isofan
Rinsulin Nph	Russia	Insulin Yaumunthu, Isofan
Rosinsulin C	Russia	Insulin Yaumunthu, Isofan

Dzina lamankhwala	Wopanga dziko	Zogwira pophika (INN)
Biosulin N	India, Russia	Insulin Yaumunthu, Isofan
Vozulim-N	India	Insulin Yaumunthu, Isofan
Gensulin N	Poland, Russia	Insulin Yaumunthu, Isofan
Protafan Nm	Denmark	Insulin Yaumunthu, Isofan
Protafan Nm Penfill	Denmark	Insulin Yaumunthu, Isofan
Humodar B Mitsinje 100	Ukraine	Insulin Yaumunthu, Isofan

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Dzina lamankhwala	Kutulutsa Fomu	Mtengo (wotsika)

Gulani mankhwala Rinsulin Nph analognpch kuyikira. s / c 100me / ml 3ml n5 (katoni)1 019.00 rub. Gulani ndi zobereka Rinsulin Nph analogr rr d / in. 100me / ml 3ml n5 (katiriji)1 005.00 rub. Gulani ndi zobereka

Dzina lamankhwala	Kutulutsa Fomu	Mtengo (wotsika)

Gulani mankhwala Chitetezo cha Protafan NmIns. nm kuyimitsidwa kwa penfil kwa jekeseni 100me / ml 3ml No. 5891.00 rub Gulani ndi zobereka Chitetezo cha Protafan NmInsulin nm vial 100me / ml 10ml372,00 rub Gulani ndi zobereka Chitetezo cha Protafan Nmnm kuyimitsidwa kwa subcutaneous makonzedwe a 100 u / ml 3 ml 5 makatoni895.10 rub. Gulani ndi zobereka Chitetezo cha Protafan Nmnm kuyimitsidwa kwa subcutaneous makonzedwe a 100 mayunitsi / 10 ml423,00 rub Gulani ndi zobereka

• Kukonzekera
• Insuman Bazal GT

Buku lamalangizo

• Wogwirizira matifiketi olembetsera: Sanofi-Aventis Deutschland, Gmbh (Germany)
• Zoyikidwa: Sanofi-Aventis Deutschland, Gmbh (Germany) Sanofi-Aventis Vostok, ZAO (Russia)

Kutulutsa Fomu
Kuyimitsidwa kwa sc makonzedwe a 100 IU / 1 ml: fl. 5 ml 5 ma PC.
Kuyimitsidwa kwa SC makonzedwe a 100 IU / 1 ml: ma cartridge 3 ml 5 ma PC., Cartridges mu syringes Solostar ® 3 ml 5 ma PC.
Kuyimitsidwa kwa sc makonzedwe a 100 IU / ml: 3 ml makatiriji 5 ma PC., Cartridges mu syringes Solostar ® 3 ml 5 ma PC.
Kuyimitsidwa kwa sc makonzedwe a 100 IU / ml: fl. 5 ml 5 ma PC.

Hypoglycemic mankhwala, sing'anga-insulin. Insuman ® Basal GT imakhala ndi insulin yofanana mu insulin yaumunthu, yomwe imapezeka ndi ma genetic engineer ogwiritsira ntchito E.coli K12 135 pINT90d.

Insulin imachepetsa kuchuluka kwa shuga m'magazi, imalimbikitsa zotsatira za anabolic komanso imachepetsa zotsatira za catabolic. Imawonjezera mayendedwe a glucose m'maselo ndi glycogen kaphatikizidwe kamisempha ndi chiwindi, imasintha magwiritsidwe a pyruvate, ndipo imalepheretsa glycogenolysis ndi gluconeogeneis. Insulin imakulitsa lipogenesis mu chiwindi ndi minofu ya adipose ndikuletsa lipolysis. Zimathandizira kutuluka kwa ma amino acid mu maselo ndi kaphatikizidwe wa mapuloteni, kumawonjezera kutuluka kwa potaziyamu m'maselo.

Insuman ® Bazal GT ndi insulin yochita masewera olimbitsa thupi pang'onopang'ono. Pambuyo pa kayendetsedwe ka sc, mphamvu ya hypoglycemic imachitika mkati mwa ola limodzi, imafika pazowonjezera pambuyo pa maola 3-4, imapitirira maola 11-20.

Mwa odwala wathanzi, T 1/2 ya plasma insulin pafupifupi mphindi 4-6. Pakulephera kwa impso, T 1/2 kutalika.

Tiyenera kudziwa kuti pharmacokinetics ya insulin sikuwonetsa metabolic yake.

Cholinga cha shuga m'magazi, kukonzekera kwa insulin komwe kumayenera kugwiritsidwa ntchito, mlingo wa insulin (Mlingo ndi nthawi yoyang'anira) uyenera kutsimikizika ndikuwusintha payekhapayekha kuti agwirizane ndi kadyedwe, mulingo wa zolimbitsa thupi ndi njira ya wodwalayo.

Palibe malamulo oyendetsedwa bwino a insulin. Komabe, pafupifupi tsiku lililonse insulin ndi 0,5-1 ME / kg thupi / tsiku, ndipo gawo la anthu la insulin nthawi yayitali 40-60% ya kuchuluka kwa insulin tsiku lililonse.

Wodwala amayenera kupatsidwa malangizo ofunikira a kuchuluka kwa shuga m'magazi, komanso malangizo oyenera a kusintha kwa zakudya kapena njira ya insulin.

Kusintha kuchokera ku mtundu wina wa insulin kupita ku Insuman ® Bazal GT

Posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina, angafunikire kuwongolera njira ya insulin yoyambira: mwachitsanzo, pakusintha kuchokera ku insulin yochokera ku nyama kupita ku insulin yaumunthu, mukasintha kuchokera ku insulin yaumunthu kukonzekera kupita ku ina, kapena mukasintha njira ya mankhwalawa a insulle yaumunthu kupita ku regimen kuphatikiza. insulin yotalikilapo.

Pambuyo pakusintha kuchokera ku insulin yochokera ku nyama kupita ku insulin ya anthu, mwina pangafunike kuchepetsa kuchuluka kwa insulin, makamaka kwa odwala omwe kale anali ndi zovuta zamagazi, odwala omwe ali ndi chizolowezi chokhala ndi hypoglycemia, mwa odwala omwe kale amafuna kuchuluka kwa insulin yayikulu chifukwa cha ndi kukhalapo kwa ma antibodies ku insulin.

Kufunika kosinthira kwa mlingo (kuchepetsa) kumatha kuchitika mutangosintha mtundu watsopano wa insulin kapena pang'onopang'ono milungu ingapo.

Mukamasintha mtundu wamtundu wa insulin kupita ku wina kenako mu masabata oyambilira, kumalimbikitsa kuyang'anitsitsa shuga wamagazi. Odwala omwe amafuna kwambiri Mlingo wa insulin chifukwa cha kupezeka kwa antibodies amalangizidwa kuti asinthane ndi mtundu wina wa insulin moyang'aniridwa ndi achipatala kuchipatala.

Kusintha kwa mlingo wowonjezera

Kuwongolera kagayidwe ka metabolic kumatha kuyambitsa chidwi cha insulini, zomwe zingapangitse kuchepa kwa kufunika kwa insulin.

Kusintha kwa mlingo kungafunikenso ngati thupi la wodwalayo lasintha, kusintha kwa moyo wake (kuphatikizapo zakudya, zolimbitsa thupi, ndi zina), zochitika zina zomwe zingakulitse chiwopsezo cha hypo- kapena hyperglycemia.

Kwa odwala okalamba, kufunika kwa insulini kungachepe. Chifukwa chake, chiyambi cha chithandizo, kuwonjezeka kwa mlingo komanso kusankhidwa kwa njira yokonzanso odwala okalamba omwe ali ndi matenda osokoneza bongo kuyenera kuchitika mosamala kuti apewe kutengeka kwa hypoglycemic.

Odwala omwe ali ndi vuto la hepatic kapena aimpso, kufunika kwa insulin kungachepe.

Kukhazikitsidwa kwa mankhwala Insuman ® Basal GT

Insuman ® Basal GT nthawi zambiri imaperekedwa mozama s / c 45-60 mphindi asanadye. Tsamba la jakisoni m'dera lomwelo liyenera kusinthidwa nthawi iliyonse. Kusintha gawo la kayendetsedwe ka insulin (mwachitsanzo, kuyambira pamimba mpaka ntchafu) kuyenera kuchitika pokhapokha mukaonana ndi dokotala, chifukwa mayamwidwe a insulini ndipo, chifukwa chake, kuchepetsa mphamvu ya shuga m'magazi kumatha kusiyanasiyana malinga ndi dera loyang'anira (mwachitsanzo, pamimba kapena
ntchafu).

Insuman ® Bazal GT siyenera kugwiritsidwa ntchito mumapampu amtundu wa insulin ambiri (kuphatikizapo omwe adalowetsedwa).

Mu / pakubweretsa mankhwala ndizosatheka!

Osasakaniza Insuman ® Basal GT ndi insulin ya ndende ina, ndi insulin ya nyama, insulin analogues kapena mankhwala ena.

Insuman ® Bazal GT ikhoza kusakanizika ndi magulu onse amakono a insulin-aventis. Insuman ® Basal GT siyenera kusakanikirana ndi insulin yomwe cholinga chake amagwiritsidwe ntchito pamapampu a insulin.

Kumbukirani kuti kuchuluka kwa insulini ndi 100 IU / ml (kwa ma ml 5 kapena ma 3 ml makatiriji), motero ndikofunikira kugwiritsa ntchito syringes zapulasitiki zokha zopangidwira insulin iyi pakagwiritsidwe ntchito Mbale, kapena OptiPen Pro1 kapena ClickSTAR syringe pokhapokha mutagwiritsa ntchito makatoni. Syringe ya pulasitiki siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Malangizo a Insuman ® Basal GT mu mbale

Pamaso gawo loyambirira la insulin kuchokera pambale, chotsani kapulasitiki (kukhalapo kwa kapuyo ndi umboni wa vial wosatsutsana). Nthawi yomweyo musanayimbe, kuyimitsidwa kumayenera kusakanikirana bwino, ndikuyika botolo pamlingo wapakati pakati pa manja ndikuwatembenuza mosamala (izi siziyenera kupanga thovu). Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikuyenera kugwiritsidwa ntchito ngati kuli ndi mtundu wina, i.e. ngati kuyimitsidwa kumakhalabe kowonekera, kapena mapepala kapena matumba apanga madziwo, pansi kapena makhoma a vial. Zikatero, muyenera kugwiritsa ntchito botolo lina lomwe likugwirizana ndi zomwe zili pamwambapa, ndipo muyenera kudziwitsa dokotala.

Asanatenge insulini kuchokera ku vial kulowa mu syringe, voliyumu yofanana ndi mlingo wa insulini uyenera kutengedwa ndikuyitanira mu vial (osalowa madzi). Kenako vial ndi syringe iyenera kutsegulidwira mozungulira ndi syringe ndikupeza kuchuluka kwa insulini. Pamaso jakisoni, chotsani thovu lakumanzere mu syringe. Pa malo a jakisoni, ndikofunikira kuphatikiza khola, ndikulowetsa singano pansi pa khungu ndikujambulira insulin pang'onopang'ono. Pambuyo pa jekeseni, singano iyenera kuchotsedwa pang'onopang'ono ndipo thonje la thonje limakankhidwa motsutsana ndi malo a jekeseni masekondi angapo. Tsiku lokhala ndi insulin kit kuchokera pa vial iyenera kulembedwa pa cholembera cha vial.

Mukatsegulira, mbale ziyenera kusungidwa pa kutentha osaposa 25 ° C kwa milungu inayi m'malo otetezedwa ku kuwala ndi kutentha.

Malangizo a Insuman ® Basal GT mu makatoni

Asanakhazikitse cartridge (100 IU / ml) mu cholembera cha sytiit ya OptiPen Pro1 ndi KlikSTAR, iyenera kusungidwa kwa maola 1-2 kutentha kwa chipinda (jakisoni a insulin yovuta kwambiri. Pambuyo pake, ndikutembenuza mokoma cartridge (mpaka nthawi 10), ndikofunikira kuti ayimitsidwe pang'ono. Kathumba kalikonse kophatikizira kamakhala ndi mipira itatu yachitsulo posakaniza mwachangu zomwe zili mkati mwake. Pambuyo pokhazikitsa cartridge mu syringe cholembera, musanayambe jekeseni iliyonse ya insulini, lembani cholembera kambirimbiri kuti muimitse kuyimitsidwa kwazokha. Pambuyo posakanikirana, kuyimitsidwa kumayenera kukhala kosasinthasintha komanso mtundu wamiyala yoyera. Kuyimitsidwa sikuyenera kugwiritsidwa ntchito ngati kuli ndi mtundu wina, i.e. ngati ikhala yowonekera, kapena ma ntchofu kapena mapampu apanga madziwo, pansi kapena pansi pa makatoni. Zikatero, muyenera kugwiritsa ntchito cartridge ina yomwe ikukwanira pamwambapa, ndipo muyenera kudziwitsa dokotala. Mafuta aliwonse am'mlengalenga amayenera kuchotsedwa katiriji musanalowe.

Katoniyo sanapangidwe kuti aphatikize Insuman ® Bazal GT ndi ma insulini ena. Makatoni opanda kanthu sangakwaniritsidwe. Pakuswa phala la syringe, mutha kulowa muyezo wofunika kuchokera pa cartridge pogwiritsa ntchito syringe yachizolowezi. Kumbukirani kuti kuchuluka kwa insulini mu cartridge ndi 100 IU / ml, chifukwa chake, syringes zapulasitiki zokha zomwe zimagwiritsidwa ntchito pozunza insulin iyi ziyenera kugwiritsidwa ntchito. Syringe siyenera kukhala ndi mankhwala ena aliwonse kapena zotsalira zake.

Mukakhazikitsa cartridge, iyenera kugwiritsidwa ntchito pakatha milungu 4. Ndikulimbikitsidwa kuti musungidwe makatiriji pamtunda wotentha osapitirira + 25 ° C pamalo otetezedwa ku kuwala ndi kutentha. Mukamagwiritsa ntchito cartridge, cholembera cha syringe sichisungidwa mufiriji (popeza jakisoni wodziwika ndi insulin yovuta kwambiri). Mukakhazikitsa cartridge yatsopano, muyenera kuyang'ananso momwe cholembera choyamba chisagwiritsire ntchito.

Malamulo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar ®

Musanagwiritse ntchito koyamba, cholembera cha syringe chimayenera kusungidwa kutentha kwa maola 1-2. Musanagwiritse ntchito, yang'anani katiriji mkati mwa cholembera mutasakaniza bwino kuyimitsidwaku mwa kutembenuza cholembera kuzungulira nkhwangwa yake, ndikuigwira pakona pakati pa manja. Cholembera cha syringe chiyenera kugwiritsidwa ntchito pokhapokha, atasakanikirana, kuyimitsidwa kuli kosasinthasintha komanso mtundu wamiyala yoyera. Cholembera sichingagwiritsidwe ntchito ngati kuyimitsidwa mkati mwake mutasakanikirana kumakhala ndi mawonekedwe ena, i.e. ngati ikhala yowonekera, kapena ma ntchofu kapena mapampu apanga madziwo, pansi kapena pansi pa makatoni. Zikatero, gwiritsani ntchito cholembera china chosiyanasiyana ndikudziwitsa adotolo.

Makina a syringe a Empty StarS ® sayenera kugwiritsidwanso ntchito, akuyenera kuwonongeka.

Popewa kutenga kachilomboka, cholembera chodzaza chisanachitike chimayenera kugwiritsidwa ntchito ndi wodwala m'modzi yekha, sayenera kusamutsidwa kwa munthu wina.

Musanagwiritse ntchito cholembera, werengani mosamala zidziwitso zanu.

SoloStar ® Syringe chole Chidziwitso

Musanagwiritse ntchito iliyonse, gwiritsani ntchito singano yatsopano mu cholembera ndikuyesa mayeso otetezeka.

Gwiritsani ntchito singano zomwe zimagwirizana ndi SoloStar ®.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso kuthekera kwa kufalikira.

Osagwiritsa ntchito cholembera cha SoloStar ® ngati chawonongeka kapena ngati mulibe chitsimikizo kuti chidzagwira ntchito moyenera.

Ndikofunikira nthawi zonse kukhala ndi cholembera cha SoloStar ® syringe kuti itayike kapena kuwonongeka kwa cholembera chachikulu cha cholembera cha SoloStar ®.

Ngati cholembera cha SoloStar ® chikusungidwa mufiriji, chikuyenera kuchotsedwa maola 1-2 isanakwane jakisoni wofunikayo kuti kuyimitsidwa kufike pa kutentha kwa chipinda. Makamaka insulini yodziwika bwino imapweteka kwambiri. Cholembera cha SoloStar ® chogwiritsidwa ntchito chimayenera kuwonongeka.

SoloStar ® syringe cholembera iyenera kutetezedwa kufumbi ndi dothi. Kunja kwa SoloStar ® Syringe cholembera kumatha kutsukidwa ndikumupukuta ndi nsalu yonyowa. Osamiza m'madzi, kutsuka ndikudzoza cholembera cha SoloStar ®, chifukwa izi zitha kuwononga.

SoloStar ® Syringe pen imapereka moyenera insulini ndipo ndiotetezeka kugwiritsa ntchito.

Cholembera cha syringe chimafuna kusamalidwa mosamala. Pewani zochitika zomwe zingawononge cholembera cha SoloStar ® Ngati cholembera cha SoloStar ® syringe chikuwoneka kuti chawonongeka, gwiritsani ntchito cholembera chatsopano.

1. Kuwongolera kwa insulin

Muyenera kuyang'anitsitsa cholembera pa SoloStar ® Syringe pen kuti muwonetsetse kuti ili ndi insulin yolondola. Mankhwala Insuman ® Basal GT syringe cholembera SoloStar ® yoyera ndi batani lobiriwira la jakisoni. Pambuyo pochotsa kapu ya cholembera, ndikofunikira kuyang'ana mawonekedwe a insulini yomwe ili mkati mwake: kuyimitsidwa pambuyo posakanikirana kuyenera kukhala ndi mawonekedwe osasinthika komanso mtundu wa milky yoyera.

2. Kulumikiza singano

Gwiritsani ntchito singano zomwe zimagwirizana ndi cholembera cha SoloStar ®. Wopanda singano yatsopano azigwiritsa ntchito jakisoni wina aliyense. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

3. Kuchita mayeso a chitetezo

Pamaso pa jekeseni iliyonse, kuyesedwa kwa chitetezo kuyenera kuchitidwa kuti zitsimikizike kuti cholembera ndi singano zimagwira bwino ndikuti thovu lakuchotsedwa limachotsedwa.

Mlingo wofanana ndi mayunitsi awiri uyenera kuyesedwa. Zovala zamkati ndi zamkati zimayenera kuchotsedwa.

Ndi cholembera ndi singano kumtunda, ikani pang'onopang'ono bokosilo la insulini ndi chala chanu kuti thovu lonse la mlengalenga likulunjikitsa pa singano.

Kanikizani batani jakisoni kwathunthu.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siyikuwoneka pamphepete mwa singano, ndiye kuti gawo lachitatu liyenera kubwerezedwa mpaka insulin itaonekere kumapeto kwa singano.

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 unit kuyambira pa mlingo wochepa (1 unit) mpaka mlingo waukulu (80 magawo). Ngati Mlingo wopitilira mayunitsi 80 ukufunika, jakisoni wa 2 kapena kupitilira uyenera kuperekedwa.

Zenera la dosing liyenera kuwonetsa "0" ndikamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

5. Dose makonzedwe

Wodwala ayenera kudziwitsidwa za njira ya jakisoni.

Singano iyenera kuyikiridwa pansi pa khungu. Batani la jakisoni liyenera kukanikizidwa kwathunthu. Mpaka singano itachotsedwa, batani liyenera kuchitidwa kwa masekondi 10. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

6. Kuchotsa ndikuwononga singano

Mulimonsemo, singano pambuyo pa jekeseni aliyense amayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Mukamachotsa ndi kuwononga singano, muyenera kusamala mosamala (mwachitsanzo, njira yovalira chipewa ndi dzanja limodzi) kuti muchepetse ngozi za ngozi zomwe zimakhudza kugwiritsa ntchito singano, komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ® ndi cap.

Hypoglycemia, zotsatira zoyipa kwambiri za mankhwala a insulin, amatha kupezeka ngati mlingo wa insulin woperekedwa umapitilira kufunikira kwake. Magawo obwerezabwereza a hypoglycemia angayambitse kukula kwa zizindikiro zamitsempha, kuphatikizapo chikomokere, kukokana. Kukhalitsa kwa nthawi yayitali kapena koopsa kwa hypoglycemia kumatha kukhala pachiwopsezo cha moyo.

Odwala ambiri, zizindikiro ndi mawonekedwe a neuroglycopenia atha kukhala patsogolo ndi zizindikiro za Reflex (poyankha kukulitsa hypoglycemia) kutsegulira kwa mtima wamanjenje. Nthawi zambiri, ndi kuchepa kwambiri kapena kuchepa msanga kwa kuchuluka kwa shuga m'magazi, chodabwitsa cha kutseguka kwa mphamvu yamanjenje yomvera chisoni ndi zizindikiro zake chimatchulidwa.

Ndi kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi, kukulitsa kwa hypokalemia (zovuta kuchokera ku mtima) kapena kukula kwa edema yamatumbo.

Otsatirawa ndi zochitika zoyipa zomwe zimayesedwa m'magulu oyeserera omwe amatsatiridwa ndi magulu opatsirana mwatsatanetsatane komanso kuchepa kwa zochitika: kawiri kawiri (≥1 / 10), nthawi zambiri (≥1 / 100 ndi zimachitika ndi ziwopsezo zosagwirizana: pafupipafupi - kugwedezeka kwa anaphylactic, pafupipafupi osadziwika - zotupa zapakhungu ponseponse, angioedema, bronchospasm, kupangika kwa ma antibodies ku insulin (nthawi zina, kukhalapo kwa ma antibodies ku insulin kungafune kusintha kwa insulin kuti athetse vuto la hyper- kapena hypoglycemia). RP G zochita nthawi yomweyo insulin kapena excipients mankhwala akhoza kuwononga moyo wa wodwala ndi amafuna umwana atangochimwa miyezo yoyenera chithandizo mwadzidzidzi.

Pa mbali ya mtima dongosolo: pafupipafupi osadziwika - kuchepa kwa magazi.

Kuchokera kumbali ya kagayidwe ndi zakudya: pafupipafupi - kutupa, kusinthasintha sikudziwika - kusungidwa kwa sodium. Zotsatira zomwezi zimatheka ndikusintha kwa kusakwanira kwa kagayidwe kachakudya chifukwa chogwiritsa ntchito kwambiri insulin.

Kuchokera kumbali ya gawo la masomphenya: pafupipafupi sikudziwika - kusokonezeka kwapang'onopang'ono (chifukwa chosintha kwakanthawi mu mawonekedwe a mandala amaso ndi cholozera chowongolera), kuwonongeka kwakanthawi machitidwe a matenda ashuga retinopathy (chifukwa cha kuphatikiza kwa insulin kwambiri ndikusintha kowongolera pakulamulira kwa glycemic), ma prosisent returosis, makamaka ngati salandira chithandizo ndi Photocoagulation (laser therapy).

Pa khungu ndi subcutaneous zimakhala: pafupipafupi sizikudziwika - kukula kwa lipodystrophy pamalo a jakisoni ndikuchepetsa pang'onopang'ono kulowetsedwa kwa insulin. Kusintha malo obayira jakisoni mkati mwa malo oyendetsera othandizira kungathandize kuchepetsa kapena kuyimitsa izi.

Zovuta ndi zovuta zina pamalo a jakisoni: pafupipafupi osadziwika - redness, ululu, kuyabwa, urticaria, kutupa kapena kutupa poyipa pamalo a jekeseni. Zinthu zomwe zimatchulidwa kwambiri ndi insulini pamalo opangira jakisoni nthawi zambiri zimatha patatha masiku angapo kapena milungu ingapo.

- Hypersensitivity insulini kapena chilichonse chothandiza cha mankhwala, pokhapokha ngati mankhwala a insulin ali ofunika.

Mochenjera, mankhwalawa ayenera kuyankhidwa ngati mankhwalawa amalephera (kuchepa kwa insulin chifukwa cha kuchepa kwa insulin metabolism), odwala okalamba (kuchepa kwapang'onopang'ono kwa ntchito ya impso kungayambitse kuchepa kwakukulu kwa insulin), mwa odwala omwe ali ndi vuto la inshuwaransi (insulin ingafunike kuchepa chifukwa cha kuchepa kwa kuthekera kwa gluconeogeneis ndi kuchepa kwa insulin metabolism, mwa odwala omwe ali ndi stenosis yayikulu yamitsempha yamagazi Odwala a x, ma epogodiccosis amatha kukhala ndi vuto lililonse pamatenda, popeza pali chiopsezo cha matenda amtima kapena chithokomiro), mwa odwala omwe ali ndi prinifosic, makamaka omwe sanalandire chithandizo ndi Photocoagulation (laser therapy), chifukwa ndi hypoglycemia, pamakhala chiopsezo chosakhalitsa amaurosis - khungu lathunthu, mwa odwala omwe ali ndi matenda amtundu wamkati (chifukwa kufunika kwa insulin kumawonjezera).

Chithandizo cha Insuman ® Bazal GT ziyenera kupitilizidwa pa nthawi ya pakati. Insulin siyidutsa chotchinga.

Kusunga moyenera kagayidwe kazakudya panthawi yonse yoyembekezera ndikovomerezeka kwa azimayi omwe ali ndi matenda ashuga asanabadwe, kapena amayi omwe apanga matenda a shuga.

Kufunika kwa insulin panthawi yapakati kumatha kuchepa mu trimester yoyamba ya kubereka ndipo nthawi zambiri kumawonjezeka mphindi yachiwiri ndi yachitatu ya kutenga pakati. Pambuyo pobadwa, insulini ikucheperachepera (chiwopsezo cha hypoglycemia). Pa nthawi ya pakati komanso makamaka mukabereka mwana, kuwunika mosamala kuchuluka kwa shuga m'magazi kumafunika.

Ngati muli ndi pakati kapena mukufuna kubereka, onetsetsani kuti mwadziwitsa dokotala.

Panthawi yoyamwitsa, palibe zoletsa pazotsatira za insulin, komabe, mlingo wa insulin komanso kusintha kwa zakudya kungafunike.

Zizindikiro: kuchuluka kwa insulini mwachitsanzo, kuyambitsa insulin yochulukirapo poyerekeza ndi kudya kapena mphamvu zamagetsi, kumatha kuyambitsa hypoglycemia yayitali komanso nthawi yayitali.

Chithandizo: Matenda ofooketsa a hypoglycemia (wodwalayo amadziwa) amatha kuyimitsidwa ndikutenga chakudya mkati. Kusintha kwa mlingo wa insulin, kudya, komanso zolimbitsa thupi kungafunike. Ziwonetsero zoopsa za hypoglycemia ndi chikomokere, kukomoka kapena kuwonongeka kwa mitsempha zitha kuyimitsidwa ndi / m kapena s / c makonzedwe a glucagon kapena iv wokhala ndi yankho lokwanira la dextrose. Mu ana, kuchuluka kwa dextrose kutumikiridwa kumayikidwa molingana ndi kulemera kwa thupi la mwana. Pambuyo pakuwonjezera kuchuluka kwa shuga m'magazi, kudya zakudya zopatsa mphamvu komanso kuunika kungafunike, popeza Pambuyo pakuwonekera kachipatala pakutha kwa zizindikiro za hypoglycemia, kuyambiranso kwake ndikotheka. Mlandu wa hypoglycemia wowopsa kapena wowerengeka wothandizidwa ndi jekeseni wa glucagon kapena makonzedwe a dextrose, tikulimbikitsidwa kuti njira yotsikira ya dextrose imayikiridwa kuti tipewe kukonzanso kwa hypoglycemia Mu ana aang'ono, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi, molingana ndi chitukuko chachikulu cha hyperglycemia.

Pazinthu zina, ndikulimbikitsidwa kuti wodwala azigonekedwa m'chipinda cha odwala osamala kwambiri kuti athe kuyang'anitsitsa momwe alili komanso kuwunika komwe akupitiliza kuchipatala.

Kugwiritsa ntchito mosiyanasiyana ndi mankhwala am'mlomo a hypoglycemic, ACE inhibitors, disopyramide, fibrate, fluoxetine, Mao inhibitors, pentoxifylline, propoxyphene, salicylates, amphetamine, anabolic steroids ndi mahomoni ogonana amuna, cybenzoline, phenophosphamine, phenophosphamine ndi phenophosphamine ake analogues, sulfonamides, tetracyclines, tritocqualin kapena trophosphamide amatha kupititsa patsogolo kuchuluka kwa insulin komanso kumawonjezera redraspolozhennost hypoglycemia.

The ntchito munthawi yomweyo corticotropin, corticosteroids, danazol, diazoxide, okodzetsa, glucagon, isoniazid, oestrogens ndi gestagens (mwachitsanzo, kupezeka PDA), phenothiazine ofanana nawo, kukula timadzi, mankhwala sympathomimetic (mwachitsanzo, wa epinephrine, salbutamol, terbutaline), mahomoni a chithokomiro, barbiturates, nicotinic acid, phenolphthalein, mankhwala a phenytoin, doxazosin imatha kufooketsa mphamvu ya insulin.

Beta-blockers, clonidine, mchere wa lithiamu ukhoza kukhala wowonjezera kapena kufooketsa mphamvu ya hypoglycemic ya insulin.

Ethanol imatha kukhala yothandiza kapena kufooketsa mphamvu ya insulin. Kudya kwa Ethanol kumatha kuyambitsa hypoglycemia kapena kuchepetsa shuga wambiri m'magazi kuti akhale owopsa. Kulekerera kwa Ethanol mwa odwala omwe amalandira insulin kumachepetsedwa. Dokotala ayenera kudziwa kuchuluka kovomerezeka kwa Mowa.

Pogwiritsa ntchito munthawi yomweyo ndi pentamidine, kukula kwa hypoglycemia ndikotheka, komwe nthawi zina kumatha kukhala hyperglycemia.

Pogwiritsa ntchito munthawi yomweyo ndi othandizira achifundo, monga beta-blockers, clonidine, guanethidine ndi reserpine, kufooka kapena kusapezeka kwathunthu kwa zizindikiro za Reflex (poyankha hypoglycemia) kutsegulira kwamanjenje lamanjenje ndizotheka.

Mankhwala ndi mankhwala.

Mankhwalawa amayenera kusungidwa kuchokera kwa ana, kutetezedwa ndi kuwala pa 2 2 mpaka 8 ° C. Osalola kuzizira! Moyo wa alumali ndi zaka 2.

Odwala omwe ali ndi vuto la kuchepa kwa hepatic, kufunika kwa insulin kungachepe.

Odwala omwe ali ndi vuto la impso, kufunika kwa insulin kungachepe.

Kwa odwala okalamba, kufunika kwa insulini kungachepe. Chifukwa chake, chiyambi cha chithandizo, kuwonjezeka kwa mlingo komanso kusankhidwa kwa njira yokonzanso odwala okalamba omwe ali ndi matenda osokoneza bongo kuyenera kuchitika mosamala kuti apewe kutengeka kwa hypoglycemic.

Ngati sikulakwa kwa glycemic control kapena chizolowezi cha matenda a hyper- kapena hypoglycemia, musanapange chisankho pakuwongolera mlingo wa insulin, ndikofunikira kuyang'ana kukhazikitsidwa kwa dongosolo lodziwika bwino la kayendetsedwe ka insulini, onetsetsani kuti insulini imalowetsedwa m'dera lomwe likunenedwa, onetsetsani kulondola kwa njira ya jakisoni ndi zina. zomwe zingakhudze zotsatira za insulin.

Chifukwa kugwiritsa ntchito munthawi yomweyo mankhwala angapo kumatha kufooketsa kapena kuwonjezera mphamvu ya hypoglycemic ya mankhwala a Insuman ® Basal GT, mukamagwiritsa ntchito mankhwalawa, simuyenera kugwiritsa ntchito mankhwala ena popanda chilolezo chodalirika kuchokera kwa dokotala.

Hypoglycemia imachitika ngati mlingo wa insulin uposa kufunika kwake.

Chiwopsezo cha kukhala ndi hypoglycemia ndi chachikulu pamayambiriro a chithandizo cha insulin, mukasinthira kukonzekera kwina kwa insulin, mwa odwala omwe ali ndi shuga yayitali m'magazi.

Monga ndi ma insulin ena, chisamaliro chapadera chiyenera kuchitika ndikuwunika kwambiri shuga wamagazi kuyenera kuchitika kwa odwala omwe ma hypoglycemic episode angakhale ndi vuto lapadera lachipatala, monga odwala omwe ali ndi vuto lalikulu la mitsempha kapena matenda amitsempha yamagazi (chiwopsezo cha mtima kapena matenda a m'magazi) komanso odwala omwe akukhala ndi proliferative retinopathy, makamaka ngati sanapatsidwe mankhwala opangira mankhwala a laser, chifukwa ali ndi chiopsezo chocheperako amaurosis (khungu lathunthu) ndi kukula kwa hypoglycemia.

Pali zizindikiro ndi zodwala zina zomwe zingasonyeze wodwala kapena ena za kukhala ndi hypoglycemia. Izi zikuphatikiza: thukuta kwambiri, chinyezi pakhungu, tachycardia, kusokonezeka kwa mtima, kuchuluka kwa magazi, kupweteka pachifuwa, kunjenjemera, njala, kugona, kusokonezeka kwa kugona, mantha, kukhumudwa, kusayenda bwino, nkhawa, kuvulala kwa nthawi mkamwa ndi kuzungulira pakamwa, kutsekeka kwa khungu, kupweteka mutu, kusokonekera kwa kayendedwe ka kayendedwe, komanso kuchepa kwa minyewa yamitsempha yamagetsi (malankhulidwe amisala ndi masomphenya, zizindikiro zakuwala) ndi zomverera zachilendo. Ndi kuchepa kwakukulu kwa ndende ya glucose, wodwalayo amatha kulephera kudziletsa ngakhalenso kuzindikira. Zikatero, kuzizira ndi chinyezi pakhungu kumatha kuonedwa, ndipo kupweteka kumawonekeranso.

Wodwala aliyense yemwe ali ndi matenda a shuga omwe amalandila insulin ayenera kuphunzira kuzindikira zizindikiro zosadziwika zomwe ndi zizindikiro za kukhala ndi hypoglycemia. Odwala omwe amayang'anitsitsa shuga m'magazi samakhala ndi hypoglycemia. Wodwalayo amatha kukonza kuchepa kwa kuchuluka kwa shuga m'magazi omwe adazindikira mwa kudya shuga kapena zakudya zambiri zamagulu ochulukitsa. Pazifukwa izi, wodwalayo ayenera kukhala ndi 20 g shuga nthawi zonse. Mokulira kwambiri kwa hypoglycemia, jekeseni wang'onopang'ono wa glucagon akuwonetsedwa, omwe angathe kuchitidwa ndi dokotala kapena ogwira ntchito manesi. Pambuyo pakusintha kokwanira, wodwalayo ayenera kudya. Ngati hypoglycemia singathetsedwe mwachangu, ndiye kuti dokotala akuyenera kuyitanidwa mwachangu. Ndikofunikira kudziwitsa dokotala mwachangu za kukula kwa hypoglycemia kuti athe kupanga chisankho pakufunika kusintha kwa insulin.

Kulephera kutsatira zakudya, kudumpha jakisoni wa insulin, kuchuluka kwa insulini chifukwa cha matenda opatsirana kapena matenda ena, komanso kuchepa kwa zochitika zolimbitsa thupi kungayambitse kuchuluka kwa shuga wamagazi (hyperglycemia), mwina ndi kuchuluka kwa matupi a ketone m'magazi (ketoacidosis). Ketoacidosis imatha kumatha maola ochepa kapena masiku. Pazizindikiro zoyambirira za metabolic acidosis (ludzu, kukodza pafupipafupi, kulephera kudya, kutopa, khungu lowuma, kupuma kwambiri komanso kuthamanga, chidwi cha acetone ndi glucose mkodzo), chithandizo chamankhwala chofunikira ndichofunikira.

Pakusintha dokotala (mwachitsanzo, nthawi yakuchipatala chifukwa cha ngozi, kudwala panthawi yopuma), wodwalayo ayenera kunena kuti ali ndi matenda ashuga.

Odwala ayenera kuchenjezedwa za momwe angasinthe, asatchulidwe pang'ono kapena asakhale ndi chenjezo lazomwe angapangitse hypoglycemia, mwachitsanzo:

- ndi kusintha kwakukulu pakulamulira kwa glycemic,

- ndi kufalikira pang'onopang'ono kwa hypoglycemia,

- odwala okalamba,

- odwala omwe ali ndi vuto la neuronomic,

- odwala omwe ali ndi matenda a shuga,

- mwa odwala omwe nthawi yomweyo amalandila chithandizo ndi mankhwala ena.

Zochitika zoterezi zimatha kuyambitsa hypoglycemia yayikulu (mwinanso kuthedwa nzeru) wodwala asanadziwe kuti akupanga hypoglycemia.

Ngati ma glycosylated hemoglobin akhazikika atapezeka, mwayi wopezeka mobwerezabwereza, wosazindikira (makamaka usiku) maganizidwe a hypoglycemia ayenera kuganiziridwanso.

Kuchepetsa chiopsezo cha hypoglycemia, wodwalayo ayenera kutsatira mosamalitsa mlingo woyenera ndi zakudya zopatsa thanzi, kupereka jakisoni wa insulin ndikuchenjezedwa ndi zizindikiro za kukhala ndi hypoglycemia.

Zinthu zomwe zimawonjezera kutsimikizira kwa chitukuko cha hypoglycemia zimafuna kuwunikira mosamala ndipo zingafune kusintha kwa mlingo. Izi ndi monga:

- kusintha m'dera loyang'anira insulin,

- kuchuluka kwa chidwi ndi insulin (mwachitsanzo, kuchotsa kwa zopsinjika),

- zachilendo (kuchuluka kapena nthawi yayitali) zolimbitsa thupi,

- Matenda ogonana (kusanza, kutsegula m'mimba),

- Zakudya zokwanira

- kudumpha chakudya,

- matenda ena omwe sanawalipire a endocrine (monga hypothyroidism ndi anterior pituitary insuffence kapena adrenal cortex insuffence),

- kugwiritsa ntchito mankhwala munthawi yomweyo.

Pa matenda apawiri, kuyendetsa kagayidwe kolimba kumafunika. Nthawi zambiri, kuyesedwa kwamikodzo kupezeka kwa matupi a ketone kumasonyezedwa, ndikusintha kwa insulin nthawi zambiri ndikofunikira. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya pang'ono, ngakhale atha kudya pang'ono kapena ngati asanza. Odwala sayenera kusiya kuperekera insulin.

Zotsatira zamtanda

Mwa kuchuluka kwakukulu kwa odwala omwe ali ndi hypersensitivity kupita ku insulin ya nyama, ndizosavuta kusinthana ndi insulin yaumunthu chifukwa cha kuyankha kwamphamvu kwa insulin ya anthu ndi insulin yochokera ku nyama. Ngati wodwalayo ali ndi hypulinensitive insulin yakuchokera kwa nyama, komanso m-cresol, kulekerera kwa mankhwala a Insuman ® Basal GT kuyenera kuwunikira kuchipatala pogwiritsa ntchito mayeso a intradermal. Ngati mayeso a intradermal akuwonetsa hypersensitivity ku insulin ya anthu (momwe angachitire, monga Arthus), ndiye kuti chithandizo china chikuyenera kuchitika moyang'aniridwa ndi achipatala.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Mphamvu ya wodwalayo yokhazikika komanso kuthamanga kwa zochitika zama psychomotor zitha kuwonongeka chifukwa cha hypoglycemia kapena hyperglycemia, komanso chifukwa chododometsa. Izi zimatha kukhala pachiwopsezo china chake munthawi yomwe maluso amafunikira (magalimoto oyendetsa kapena njira zina).

Odwala ayenera kusamala ndikupewa hypoglycemia poyendetsa. Izi ndizofunikira kwambiri kwa odwala omwe achepetsa kapena kusazindikira zizindikiro za hypoglycemia, kapena omwe ali ndi zochitika zapafupipafupi za hypoglycemia. Odwala otere ayenera kusankha payekhapayekha kusankha magalimoto kapena njira zina.

Zotsatira za pharmacological

Insulin yochita pakati. Kuchepetsa kuchuluka kwa shuga m'magazi, kuonjezera mayamwidwe ndi minofu, kumapangitsanso lipogenis ndi glycogenogeneis, kaphatikizidwe ka mapuloteni, kumachepetsa kuchuluka kwa shuga ndi chiwindi.

Imalumikizana ndi cholandirira china kumtundu wakunja wamaselo ndikupanga insulini yolandirira. Mwa kuyambitsa kaphatikizidwe ka cAMP (m'maselo amafuta ndi maselo a chiwindi) kapena kulowa mwachindunji mu cell (minofu), insulini yolandirira insulin imapangitsa njira zina, kuphatikizira kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase, etc.). Kutsika kwa shuga wamagazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kake ka chidwi, kuchuluka kwa zotupa, kukondoweza kwa lipogenesis, glycogenogeneis, kaphatikizidwe ka mapuloteni, kuchepa kwa kuchuluka kwa kupanga kwa shuga ndi chiwindi (kuchepa kwa kuphwanya glycogen), ndi zina zambiri.

Pambuyo pa jekeseni wa sc, matendawa amapezeka maola 2 mpaka 2. Kuchuluka kwa gawo lomwe kuli pakati pa maola 2-12, kutalika kwa nthawi ndi maola 18-24, kutengera kapangidwe ka insulin ndi mlingo, kumawonetsa kupatuka kwakapakati komanso mkati mwa munthu.

Mtundu woyamba wa shuga.

Type 2 shuga mellitus, gawo la kukana mankhwalawa a hypoglycemic, kutsutsana kwapakamwa kwa mankhwala a hypoglycemic (kuphatikiza mankhwala), matenda oyanjana, chithandizo cha opaleshoni (mono- kapena chithandizo chamankhwala), matenda a shuga nthawi yayitali.

Zotsatira zoyipa

Thupi lawo siligwirizana (urticaria, angioedema - malungo, kufupika, kuchepa kwa magazi),

hypoglycemia (pallor of the khungu, thukuta kwambiri, thukuta, pakamwa, kunjenjemera, njala, kusokonezeka, nkhawa, paresthesias mkamwa, kupweteka mutu, kugona, kugona, mantha, kupsinjika, kusakwiya, chikhalidwe chosazolowereka, kusowa kwa kayendedwe, vuto lakulankhula ndi kuyankhula komanso masomphenya), hypoglycemic coma,

hyperglycemia ndi matenda ashuga acidosis (pa Mlingo wochepera, kulumpha jakisoni, kusadya bwino, kutentha thupi komanso matenda): kuwodzera, ludzu, kusowa chilakolako chofuna kudya,

kuda nkhawa (mpaka kukula kwa precomatose ndi chikomokere),

kuchepa kwakanthawi kwakanthawi (nthawi zambiri kumayambiriro kwa zamankhwala),

immunological cross-reaction ndi insulin ya anthu, kuwonjezeka kwa gawo la anti-insulin antibodies, kenako kuwonjezeka kwa glycemia,

Hyperemia, kuyabwa ndi lipodystrophy (atrophy kapena hypertrophy of subcutaneous fat) pamalo a jekeseni.

Kumayambiriro kwa mankhwalawa - kutupa ndi kusokonezeka komwekonso (ndizosakhalitsa ndipo kumatha ndikupitilira chithandizo).

Malangizo apadera

Musanatenge insulini kuchokera ku vial, ndikofunikira kuti muwone mawonekedwe a yankho. Matupi achilendo atawonekera, kusefukira kapena kutentha kwa zinthu pagalasi la botolo, njira yothetsera mankhwalawa singagwiritsidwe ntchito.

Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.

Mlingo wa insulin uyenera kusinthidwa matenda opatsirana, matenda a chithokomiro, matenda a Addison, hypopituitarism, kulephera kwaimpso ndi matenda ashuga okonda anthu opitirira zaka 65.

Zomwe zimayambitsa hypoglycemia zimatha kukhala: kuchuluka kwa insulini, kusintha mankhwala osokoneza bongo, kudumpha chakudya, kusanza, kutsegula m'mimba, kupsinjika kwa thupi, matenda omwe amachepetsa kufunika kwa insulin (matenda apamwamba a impso ndi chiwindi, komanso hypofunction ya adrenal cortex, pituitary kapena chithokomiro chithokomiro), kusintha malo jakisoni (mwachitsanzo, khungu pamimba, phewa, ntchafu), komanso mogwirizana ndi mankhwala ena. Ndikotheka kuchepetsa kuchuluka kwa shuga m'magazi mukachotsa wodwala kuchokera ku insulin ya nyama kupita ku insulin ya anthu. Kusamutsa wodwala kupita ku insulin yaumunthu kuyenera kukhala kovomerezeka nthawi zonse ndikuyang'aniridwa ndi dokotala.

Chizolowezi chokhala ndi hypoglycemia chimatha kuvulaza kuthekera kwa odwala kutenga nawo mbali mokwanira mumsewu, komanso kukonza makina ndi zida zake.

Odwala omwe ali ndi matenda ashuga amatha kuyimitsa pang'ono hypoglycemia yomwe amamva pakudya shuga kapena zakudya zopatsa thanzi (tikulimbikitsidwa kuti nthawi zonse muzikhala ndi shuga osachepera 20 g). About hypoglycemia yosamutsidwa, ndikofunikira kudziwitsa dokotala kuti athetse vuto la kufunika kwa chithandizo chamankhwala. Pa nthawi yoyembekezera, ndikofunikira kuganizira kuchepa (I trimester) kapena kuwonjezeka (II-III trimesters) pazofunikira za insulin. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri. Pa mkaka wa m`mawere, kuwunikira tsiku ndi tsiku kumafunikira kwa miyezi ingapo (mpaka kufunika kwa insulin kukhazikika).

Kuchita

Mankhwala osagwirizana ndi mayankho a mankhwala ena.

Mphamvu ya hypoglycemic imapangidwira ndi sulfonamides (kuphatikizapo mankhwala a hypoglycemic, sulfonamides), ma inhibitors a MAO (kuphatikizapo furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (kuphatikizapo salicylates), anabolic (kuphatikiza stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + kukonzekera, pyridoxine, quinidine, quinine, etloroquin, etloro.

Zotsatira Hypoglycemic wa kulemala glucagon, kukula timadzi, corticosteroids m'kamwa kulera, estrogens, thiazide ndi kuzungulira okodzetsa, mahomoni BCCI, chithokomiro, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, calcium muzikangana, diazoxide, morphine, chamba, fodya, phenytoin, epinephrine, H1-histamine receptor blockers.

Beta-blockers, reserpine, octreotide, pentamidine imatha kuwongolera ndi kufooketsa mphamvu ya hypoglycemic ya insulin.

Katswiri wa matenda ashuga: "kukhazikika pamlingo wamagazi."

Kupanga ndi mawonekedwe a kumasulidwa

Insulin basal imapezeka m'mitundu itatu:

1. Kulongedza mabotolo asanu, lililonse kumamililo asanu,
2. Botolo limodzi pamamilimita khumi,
3. Makatoni amamilita atatu, ma syringe pensulo. Kathumba kalikonse kamakhala ndi kapisozi kokhala ndi 1 ml yogwira ntchito.

Cartridges ndiwotchuka kwambiri, chifukwa kusintha kwawo sikovuta, ndipo kugwiritsa ntchito cholembera sikungakhale kosavuta komanso kosapweteka.

Mu botolo lililonse kapena katoni, mu 1 millilita wa zinthu ali pafupifupi 100 IU ya insulin.

Chithandizo chotsitsa shuga chili ndi:

• Insulin yaumunthu - ndiye chinthu chachikulu chogwira ntchito, ndikofunikira kuyang'anitsitsa mlingo womwe umayendetsedwa, kuti mupewe kumwa kwambiri kapena kusakwanira kwa insulin, yomwe ingayambitse zotsatira zake,
• M-cresol - pokonzekera iyi ilipo yochepa, imagwira ntchito ngati zosungunulira zina, komanso monga antiseptic, pharmacodynamics ndi pharmacokinetics

Mankhwalawa amachokera ku insulin ya anthu, pokhapokha kuwonjezera pazinthu zomwe zimakhudza mayamwidwe ndi nthawi yayitali.

Katundu wotsitsa shuga wa Insuman Bazal imatheka chifukwa cha:

1. Imathandizira kuchulukitsa kwa shuga kuchokera mthupi - nthawi yomweyo pamakhala kufooka komwe kumalepheretsa mayamwidwe am'mimba m'matumbo am'mimba, komanso kuthamanga kwa shuga ndi impso,
2. Kulowetsedwa kwa shuga ndi minofu ya thupi kumawonjezeka - chifukwa chomwe, glucose ambiri amalowera minyewa ndi maselo amthupi, chifukwa chomwe kuchuluka kwake m'magazi kumachepa,
3. Kuthamanga kwa liponeogeneis - malowa amatsogolera pagulu lamafuta amthupi, popeza ma carbohydrate m'magazi amasinthidwa ziwalo zamkati. Ndipo metabolite yomwe imayikidwa imayikidwa mu minofu yolowera, omentum, minofu ndi minyewa ina ngati mafuta,
4. Kukondoweza kwa glyconeogeneis - mu nkhani iyi, kupangika kwina kwa shuga kumapangidwa, komwe ndi polysaccharide. Ndikusowa kwa magazi m'magazi, polysaccharide iyi imaphwanya ndikuchulukitsa magazi ake,
5. Kuchepa kwa kapangidwe ka shuga ndi chiwindi - m'chiwindi mumakhala michere yambiri, mafuta komanso mapuloteni, omwe mothandizidwa ndi ma enzyme ena amatha kupanga shuga,
6. Kapangidwe ka insulin receptors - kupangidwako kumakhala pakhungu lakunja la maselo a thupi, ndikuwonjezera kudutsa kwa glucose mkatikati, komwe kumachepetsa kuyika kwake m'magazi ndikuwonjezera mphamvu ya khungu. Izi zimagwiritsidwa ntchito bwino ndi osewera omwe akufuna kukwaniritsa zotsatira zabwino pogwiritsa ntchito insulin.

Kutsatira malangizo ogwiritsa ntchito, Insuman Bazal, iyenera kuyendetsedwa mosakakamiza. Izi ndizofunika kupewa kuwonjezeka kwambiri kwa insulin m'magazi. Chifukwa chake, nthawi zonse muyenera kuwongolera nthawi yoyendetsa ndi kuwerengera nthawi ya jakisoni wotsatira, chifukwa zotsatira za mankhwalawa zimatheka patatha maola 1-2 mutatha kuyendetsa, ndipo mphamvu yakeyo imawonekera kwa maola 20-24.

Mankhwalawa amagwiritsidwa ntchito popanga matenda a shuga a shuga a mtundu woyamba. Inde, ndi mitundu yosiyanasiyana ya matendawa, kuchepa kwa kapangidwe ka insulin ndi maselo a Langerhans mu kapamba kumawonedwa, komwe kumafunika kugwiritsa ntchito mankhwalawa.

Mankhwalawa amagwiritsidwa ntchito ngati mankhwala a insulin a nthawi yayitali, amatha kuphatikizidwa ndi insulin Rapid yolimba kwambiri.

Gwiritsani ntchito Insuman Bazal GT mu cholembera kapena mothandizidwa ndi ma insulin, ndikofunikira kuti mugwirizane ndi dokotala. Pankhaniyi, madyerero oyamba ayenera kukhala mu chipatala moyang'aniridwa ndi katswiri. Ithandizira kuwongolera kuchuluka kwa insulin, kuwongolera kuyambitsidwa kwa mankhwala a tsiku ndi tsiku, komanso kuwona momwe thupi limayankhira pomvera mankhwalawa.

Palibe mankhwala enieni ogwiritsira ntchito mankhwalawa, chifukwa mlingo uliwonse umasankhidwa kwa wodwala aliyense. Mlingo watsiku ndi tsiku amawerengedwa molingana ndi kulemera kwa thupi ndipo ndi 0.4-1.0 U / kg.

Mukamawerengera, muyenera kuganizira momwe wodwalayo amatsatira chithandizo chamankhwala, chomwe chimatsogolera moyo wake, ntchito zake patsiku. Mankhwala ayenera kuperekedwa mosamala. Chofunikira ndikusintha kwa jakisoni. Izi ndizofunikira chifukwa cha momwe mankhwala am'deralo amathandizira, komanso kupewa kwa kuwonongeka kwa minofu ndikuwonongeka kwa necrosis komanso utsogoleri wa mankhwalawa.

Zochita zoterezi zimayenera kugwirizanitsidwa ndi adokotala. Popeza magawo osiyanasiyana amthupi amakhala ndi magawo osiyanasiyana a chitukuko cha ma network a magazi ndi ziwiya zamitsempha, chifukwa cha izi, gawo la insulin lomwe limalowa m'magazi limatha kusintha.

Dokotala ayenera kuganizira momwe kuchuluka kwa glucose kumasinthira pamene Insuman imaperekedwa m'malo osiyanasiyana a jakisoni.

Mukamagwiritsa ntchito Insuman Bazal, mawonekedwe awa akuyenera kuganiziridwa:

• Malo oyambira
• Kusintha kwa kulemera kwa thupi - ndi kuwonjezeka, Mlingo ukuwonjezeka, motere, kuthana ndi insulin kumatha kuchitika, kuwonjezeka kwa ndende ya glucose komanso kukula kwa zodwala.
• Kusintha kwa kadyedwe ndi kakhalidwe - chakudya cha anthu odwala matenda ashuga ndi cholinga choti magazi azikhala ndi shuga pafupipafupi, ngati angasinthe mtundu wa zakudya kapena kusintha menyu, mulingo woyenera wa mankhwalawa uyenera kuyambiranso. Zochita zotere ziyenera kuchitika atasintha moyo wawo, nthawi zina, odwala amafunikira insulin (chithunzi), ndipo mwa ena, mlingo waukulu (matenda, ntchito yochepa),
• Kutembenukira ku insulin ya munthu kuchokera ku chinyama - zotere zimachitika pokhapokha kuyang'aniridwa ndi adokotala, ndiye yekha amene ayenera kusintha mlingo. Mu odwala matenda ashuga, mumakhala chidwi cha insulin yaumunthu, nthawi zambiri mankhwalawa amachepetsa.

Ndi chitukuko cha matenda omwe akuphatikizidwa ndi kulephera kwa chiwindi kapena kutsogolera kwake, kuwongolera kwa glucose kuyenera kuchitidwa ndi kuchuluka kwa shuga ya mankhwala ochepetsa kuchepetsedwa. Popeza kagayidwe ka insulin kamachepetsedwa, komanso kaphatikizidwe ka glucose m'chiwindi.

Njira zopewera kupewa ngozi

Musanaimbire mwachindunji mankhwala, muyenera kuonetsetsa kuti ndi abwino.Kuti muchite izi, muyenera kutenga botolo, ndikuonetsetsa kuti pali kapu ya pulasitiki yomwe imati sinatsegulidwe. Kenako yang'anani mkhalidwe wa yankho la matenda omwewo.

Ikhale yoyera, opaque, yosasinthasintha. Ngati mpweya, kukhalapo kwa ma flakes, kuwonekera kwa kuyimitsidwa palokha kumawonedwa, izi zikuwonetsa mkhalidwe wopanda vuto la mankhwala.

Asanayimbe, kuyimitsidwa kumayenera kusakanizidwa bwino. Mu syringe, jambulani mpweya malingana ndi mlingo womwe mukufuna ndipo mulowe mu vial osakhudza kuyimitsidwa komwe. Kenako, osatenga singano, tembenuzani botolo ndikusonkhetsa mlingo wa Insuman.

Pankhani yogwiritsa ntchito ma cholembera ndi ma cartridge, ndikofunikanso kuwunika momwe kuyimitsidwira palokha ndikugwira ntchito kwa cholembera. Asanayambe makonzedwe, muyenera kutembenuzira pang'ono kapena kugwedeza chipangizocho kangapo kuti muyimitsidwe.

Ngati zolembera za syringe zasweka, ndipo palibe mwayi wogula watsopano pakadali pano, mutha kugwiritsa ntchito syringe. Insuman Bazal imakhala ndi 100 IU / ml, chinthu chachikulu chomwe chimagwira, kotero muyenera kugwiritsa ntchito ma syringe omwe amapangidwira mwachindunji Mlingo wa mankhwalawa.

Zotsatira zoyipa

Poyerekeza ndi kagwiritsidwe ka ntchito ka Insuman nthawi zonse, chitukuko cha

1. Hypoglycemia - mlingo wa insulin wopitilira muyeso, kapena ngati thupi silikufunika lina,
2. Hyperglycemia - imayamba kumachitika pafupipafupi, imawonetsa kuchuluka kwa insulin kapena kuchepa kwamphamvu kwa thupi la mankhwalawo.

Mikhalidwe yotere imayendera limodzi ndi chizungulire chachikulu, kutayika kwa chikumbumtima, mantha, kumva mwamphamvu njala. Komanso pamakhala mutu wovuta, kuda nkhawa, kusokonekera, kuphwanya koyenera mogwirizana.

Pochera mosalekeza shuga, odwala amakhala ndi tachycardia, kutsika kwa magazi, ndi khungu lotuwa.

Kuchepa pafupipafupi kumachepa ndikuwonjezereka kwa glucose amathanso kusiya zotsatira zosafunikira pa thanzi la munthu. Zikatero, angiopathy ang'onoang'ono ziwiya zosiyanasiyana kutulutsidwa. Nthawi zambiri, kuwonongeka kwa mawonekedwe, khungu limayamba kuda. Mkhalidwe wamakono wozungulira wamagetsi umatsogolera pakupanga khungu.

Ndi kuyambitsidwa kosalekeza kwa insulin pamalo amodzi, kuwonongeka kwa minyewa yodutsa m'mimba kumachitika pamenepo, chilonda chimachitika. Komanso, machitidwe oterewa angayambitse kukula kwa abscess kapena minofu necrosis.

Hypersensitivity reaction ikhoza kukhala pazigawo za Insuman, zomwe zimayendera limodzi ndi kuyabwa kwambiri, zotupa pakhungu, ndikulowerera kolowera kapena malo akuda, zomwe zikuwonetsa minofu necrosis (zochitika za Arthus). Mwina kuwoneka kwa mavuto kupuma, kuwonetsa kukula kwa bronchospasm, angioedema, redness of all khungu.

Bongo

Mothandizidwa ndi insulin yayikulu, thupi limayamba kukula. Zizindikiro zoyambirira zikaonekera, ndikofunikira kuchitapo kanthu kuti mupewe izi. Choyamba, muyenera kuchita mayeso owonetsa kuchuluka kwa shuga m'magazi. Ngati zizindikirozo ndizochepa, muyenera kutenga shuga pang'ono.

Pofuna kutaya chikumbumtima, kufalikira kwamphamvu kwa glucose kumathandizidwa ndi okhudzidwa, mwamphamvu, kenako dontho ndikulumikizidwa ndi yankho la shuga. Pambuyo pake wodwalayo amawayang'aniridwa ndikuwonetsetsa kuti shuga ya magazi imayesedwa pafupipafupi.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi nthawi zingapo zamankhwala ochepetsa shuga kumabweretsa kukula kwa chikumbumtima cha hypoglycemic, ndikofunikira kugwirizanitsa kudya ndi mankhwala ndi dokotala.

Amaletsanso kumwa Insuman ndi mankhwala omwe amatha kuchepetsa mphamvu ya mankhwala opatsirana, omwe amaphatikizapo: emtrogens, sympathomimetics, mahomoni a chithokomiro, diuretics, somatotropin ndi analogues, antipsychotic mankhwala.

Ngati wodwala akuyenera kumwa mankhwalawa, nthawi zoterezi ziyenera kuvomerezedwa ndi adokotala.

Ma Analogs ndi mtengo wake

Mtengo wa Insuman base pamtunda wa Russia umachokera ku ruble 765,00 rubles 1,585.

Ngati ndi kotheka, titha kugwirizanitsa ndikugwiritsa ntchito mtsogolo ntchito zina za Insuman Bazal analogues. Amakhala ofanana kapangidwe kake komanso kutalika kwa zochita. Mulinso zochokera mu insulin ya anthu, kuphatikiza kwa ochulukitsa ena.

Analogs of Insuman Bazal ndi:

1. Protafan TM, kupanga - Denmark. Hypoglycemic iyi ikhoza kugulidwa pamtengo wa 850 rubles mpaka 985 rubles.
2. Rinsulin NPH, kupanga - Russia. Chida ichi chimapezeka m'mabotolo ndi ma cartridge, mutha kugula pamtengo wa ma ruble 400 mpaka ma ruble 990.
3. Humulin NPH, Production - USA. M'mafakitale mumatha kupezeka pamtengo wa ma ruble a 150-400.