Ogwira ntchito kwakutali insulins (ATX A10AE)

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Lantus. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Lantus machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Lantus analogues pali kupezeka kwa mawonekedwe. Gwiritsani ntchito mankhwalawa odwala matenda a shuga a odwala matenda a shuga, akulu, ana komanso pa nthawi ya bere. The zikuchokera mankhwala.

Lantus - ndi analogue ya insulin ya anthu. Kupezedwa ndi kubwezeretsanso kwa mabakiteriya a DNA amtundu wa Escherichia coli (E. coli) (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Mu kapangidwe kamankhwala Lantus, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitates, omwe ochepa insulin glargine (chinthu chogwira kukonzekera kwa Lantus) amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda). Kutalika kwa mankhwala.

Ma paramu omangira a insulin glargine ndi insulin ya anthu ali pafupi kwambiri. Glulin insulin imakhala ndi mphamvu yofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe ka glucose. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi ya insulin glargine makamaka chifukwa cha kuchepa kwake, komwe kumapangitsa kuti mankhwalawa azigwiritsidwa ntchito kamodzi patsiku. Kukhazikika kwa pafupifupi ndi ola limodzi pambuyo pa sc makonzedwe. Kutalika kochedwa kwa maola ndi maola 24, kutalika kwake ndi maora 29. Chikhalidwe cha insulin ndi mawonekedwe ake (mwachitsanzo, insulin glargine) pakapita nthawi amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Kutalika kwa mankhwala Lantus ndi chifukwa kukhazikitsidwa kwake mafuta oyambira.

Kupanga

Insulin glargine + akubwera.

Pharmacokinetics

Kafukufuku wofananira wa kuzungulira kwa insulin glargine ndi insulin-isophan pambuyo pokhazikika pamayendedwe a magazi mu seramu mwa anthu athanzi komanso odwala omwe ali ndi matenda osokoneza bongo amawulula kuchepa pang'onopang'ono komanso kutalikirana kwambiri, komanso kusapezeka kwa nsonga ya insulin glargine poyerekeza ndi insulin-isofan.

Ndi s / c pokonzekera mankhwalawa 1 kamodzi patsiku, khola la insulin glargine m'magazi limakwaniritsidwa patatha masiku awiri ndi atatu atatha kumwa.

Ndi mtsempha wamkati, theka la moyo wa insulin glargine ndi insulin yaumunthu imafanana.

Mwa munthu yemwe wakula mafuta osunthika, insulin glargine imakhazikika pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kuti ipange 21A-Gly-insulin ndi 21A-Gly-des-30B-Thr-insulin.Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

Zizindikiro

• matenda a shuga omwe amafunikira chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 6,
• shuga mellitus ofuna chithandizo cha insulin mwa akulu, achinyamata ndi ana opitilira zaka 2 (a fomu ya SoloStar).

Kutulutsa Mafomu

Yankho la subcutaneous makonzedwe (3 ml makatiriji mu OptiSet ndi OptiKlik syringe zolembera).

Njira yothetsera ma subcutaneous makonzedwe (3 ml cartridgeges ku Lantus SoloStar syringe pens).

Malangizo ogwiritsa ntchito ndi chiwembu chogwiritsira ntchito

Lantus OptiSet ndi OptiKlik

Mlingo wa mankhwalawa komanso nthawi yakatsiku la kasamalidwe ake imayikidwa payekhapayekha. Lantus amatumizidwa kamodzi kamodzi patsiku, nthawi imodzi. Lantus amayenera kubayidwa m'mafuta am'mimba, phewa kapena ntchafu. Masamba obaya jekeseni amayenera kusinthana ndi mankhwala atsopano aliwonse omwe ali m'malo omwe akutsimikiziridwa kuti mankhwalawo ndi othandizira.

Mankhwalawa angagwiritsidwe ntchito onse ngati monotherapy, komanso kuphatikiza ndi mankhwala ena a hypoglycemic.

Posamutsa wodwala kuchokera ku insulin ya nthawi yayitali kapena yapakatikati yopita ku Lantus, pangafunike kukonza njira ya tsiku ndi tsiku ya basal insulin kapena kusintha kwa ofanana ndi mankhwala osokoneza bongo (Mlingo ndi mawonekedwe a makulidwe a insulin kapena malingaliro awo, komanso Mlingo wa mankhwala osokoneza bongo a hypoglycemic).

Mukasamutsa wodwala kuchokera pakulidwe ka insulin kawiri kawiri kulowa jekeseni imodzi ya Lantus, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri. Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, kenako ndikusintha kwa Mlingo wa mankhwala.

Monga ma fanizo ena a insulin yaumunthu, odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu amatha kuwona kuwonjezeka kwa kuyamwa kwa insulin pamene akusintha kupita ku Lantus. Mukasinthira ku Lantus komanso milungu yoyamba itatha, kuyang'anira shuga m'magazi ndikofunikira ndipo ngati pakufunika kuthandizidwa, mupeze mankhwalawa.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena ngati zinthu zina zikuwoneka kuti zikuwonjezera kukonzekera kwa hypo- kapena hyperglycemia.

Mankhwala sayenera kuperekedwa. Mu / pakubweretsa njira yanthawi zonse, yolimbikitsidwa ndi sc, kungayambitse kukula kwa hypoglycemia.

Asanakhazikitsidwe, muyenera kuwonetsetsa kuti ma syringe alibe zotsalira zamankhwala ena.

Malamulo ogwiritsira ntchito ndikugwiritsa ntchito mankhwalawa

OptiSet asanadzaze ma syringe pensulo

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi. Ma cholembera opanda kanthu a OptiSet sanapangidwe kuti agwiritsenso ntchito ndipo akuyenera kuwonongeka.

Popewa kutenga kachilomboka, cholembera chomwe chimakhala chodzaza ndi chida chokha chogwiritsidwa ntchito ndi wodwala m'modzi yekha ndipo sichingasamutsidwe kwa munthu wina.

Kugwira cholembera cha OptiSet Syringe

Pa ntchito iliyonse yotsatira, gwiritsani ntchito singano yatsopano. Gwiritsani masingano okha oyenera cholembera cha OptiSet.

Jekeseni iliyonse isanachitike, kuyesedwa koyenera kuyenera kuchitidwa nthawi zonse.

Ngati cholembera chatsopano cha OptiSet chikugwiritsidwa ntchito, kukonzekera kuyesa kugwiritsa ntchito kuyenera kuchitika pogwiritsa ntchito magawo 8 osankhidwa ndi wopanga.

Wosankha mlingo akhoza kuzunguliridwa mbali imodzi.

Osatembenuza wokonza mlingo (kusintha kwa mlingo) mutakanikiza batani loyambira jakisoni.

Wina akapaka jakisoni kwa wodwala, ayenera kusamalidwa mwapadera kuti apewe kuvulala mwangozi ndi matenda opatsirana.

Osamagwiritsanso ntchito cholembera cha sytige ya OptiSet yowonongeka, komanso ngati vuto lakukayikira likuwoneka.

Ndikofunikira kukhala ndi cholembera cha sytige yopumira ya OptiSet ngati mutayika kapena kuwonongeka kwa omwe mumagwiritsa ntchito.

Mukachotsa chipewa mu syringe cholembera, onetsetsani zomwe zili patsamba losungirako la insulin kuti zitsimikizire kuti ili ndi insulin yoyenera. Maonekedwe a insulini ayeneranso kufufuzidwa: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, lopanda zinthu zolimba zowoneka komanso lokhazikika monga madzi. Osagwiritsa ntchito cholembera cha sytinge ya OptiSet ngati njira ya insulin ndi yopanda mitambo, yothinitsidwa kapena yokhala ndi tinthu tachilendo.

Mukachotsa kapu, samalirani mosamala ndikulowetsa singano ndi cholembera.

Kuyang'ana kukonzeka kwa cholembera kuti mugwiritse ntchito

Pamaso pa jekeseni iliyonse, ndikofunikira kuyang'ana kukonzekera kwa cholembera kuti mugwiritse ntchito.

Kwa cholembera chatsopano chatsopano komanso chosagwiritsidwa ntchito, chizindikiro cha mankhwalawa chiyenera kukhala nambala 8, monga momwe zimapangidwira kale ndi wopanga.

Ngati cholembera chikagwiritsidwa ntchito, wopereka amayenera kuzunguliridwa mpaka chizindikiritso cha mankhwalawo chikuima nambala 2. Wowunikirawo azizungulira mbali imodzi yokha.

Kokani batani loyambira kwathunthu kuti mupeze mlingo. Osazungulira wosankha wa mankhwalawo mutatha batani loyambira litulutsidwe.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa. Sungani kapu yakunja kuti mupeze singano yogwiritsidwa ntchito.

Mukugwira cholembera ndi singano yoloza m'mwamba, ikani pang'onopang'ono zitsulo za insulini ndi chala chanu kuti thovu lakumwamba lithe kulunjika ku singano.

Pambuyo pake, dinani batani loyambira njira yonse.

Ngati dontho la insulin litulutsidwa kuchokera kunsonga ya singano, cholembera cha singano ndi singano chimagwira ntchito molondola.

Ngati dontho la insulin silikuwoneka pamphepete mwa singano, muyenera kubwereza kuyeserera kwa cholembera kuti mugwiritse ntchito mpaka insulin itaonekere kumapeto kwa singano.

Mankhwala a insulin

Mlingo wa mayunitsi 2 mpaka 40 ungayikidwe mu zowonjezera za 2 mayunitsi. Ngati mlingo wopitilira mayunitsi 40 ukufunika, uyenera kutumikiridwa pobayira ziwiri kapena zingapo. Onetsetsani kuti muli ndi insulin yokwanira muyezo wanu.

Mulingo wa insulin yotsalira pachidebe cha insulin imawonetsa kuchuluka kwa insulini yotsalira mu cholembera cha sytiitet ya OptiSet. Mlingowu sungagwiritsidwe ntchito kumwa mankhwala a insulin.

Ngati piston wakuda ali kumayambiriro kwa mzere wachikuda, ndiye kuti pali magawo 40 a insulin.

Ngati pisitoni wakuda ili kumapeto kwa mzere wachikuda, ndiye kuti pali magawo 20 a insulin.

Wosankha mlingo uyenera kutembenuzidwa mpaka muvi womwenso uwonetsa mlingo womwe ungafune.

Kumwa kwa insulin

Batani loyambira jekeseni liyenera kukokedwa mpaka kumalizira kuti mudzaze cholembera.

Ziyenera kuwunikidwa ngati mulingo wofunikira uli ndi zonse. Batani loyambira limasuntha molingana ndi kuchuluka kwa insulini yomwe yatsala mu thanki ya insulin.

Yambitsani batani limakupatsani mwayi kuti muone ngati ndiwomwe udayamwa. Mukamayesedwa, batani loyambira liyenera kupitilizidwa mphamvu. Mzere womaliza wowoneka bwino pabatani wayambira kuchuluka kwa insulin yomwe yatengedwa. Pokhazikitsa batani loyambira, pamwamba pamzerewu ndiwowoneka.

Ophunzitsidwa mwapadera ayenera kufotokozera wodwalayo njirayo.

Singano imalowetsedwa pang'onopang'ono. Batani loyambira jekeseni liyenera kukanikizidwa mpaka pakufika. Kungodinanso kukusiyani pomwe batani la jekeseni litakankhidwa njira yonse. Kenako, batani loyambira jakisoni liyenera kusindikizidwa kwa masekondi 10 musanachotsere singano pakhungu. Izi zitsimikiza kukhazikitsidwa kwa mlingo wonse wa insulin.

Pakapita jakisoni aliyense, singano imayenera kuchotsedwa mu cholembera ndikuchotsa. Izi zimathandiza kupewa matenda, komanso kutayika kwa insulini, kudya kwa mpweya komanso kuthekera kwa singano. Singano sizingagwiritsenso ntchito.

Pambuyo pake, valani chipewa cha syringe cholembera.

Makatoni amayenera kugwiritsidwa ntchito limodzi ndi cholembera cha syringe ya OptiPen Pro1, komanso molingana ndi malingaliro omwe adaperekedwa ndi wopanga chipangizocho.

Malangizo ogwiritsira ntchito cholembera cha sytige ya OptiPen Pro1 okhudza kukhazikitsidwa kwa katiriji, zolumikizira singano, ndi jakisoni wa insulin ziyenera kutsatiridwa chimodzimodzi. Yenderani cartridge musanagwiritse ntchito. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe tizinthu totsimikizika tolimba. Asanakhazikitse cartridge mu syringe cholembera, cartridge iyenera kukhala pakupanda kutentha kwa maola 1-2. Musanalowetse jakisoni, chotsani thovu lakumtunda. Ndikofunikira kutsatira mosamalitsa malangizo. Makatoni opanda kanthu sagwiritsidwanso ntchito. Ngati cholembera cha sytiit ya OptiPen Pro1 chawonongeka, simuyenera kuchigwiritsa ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala posankha yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochita 100 IU / ml).

Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito cholembera.

Optical Dinani Cartridge System

Pulogalamu yama cartridge ya OptiClick ndi kapu yagalasi yokhala ndi 3 ml ya insulin glargine solution, yomwe imayikidwa mu chidebe chowoneka bwino cha pulasitiki chomwe chili ndi zida za piston.

Dongosolo la cartridge la OptiClick liyenera kugwiritsidwa ntchito limodzi ndi cholembera cha sytinge ya OptiClick molingana ndi malangizo ogwiritsira ntchito omwe adabwera nawo.

Malangizo onse omwe ali mu malangizo a kukhazikitsa dongosolo la cartridge mu cholembera cha OptiClick, kulumikiza singano, ndi kubayidwa kuyenera kutsatiridwa mosamalitsa.

Ngati cholembera cha sytiit ya OptiClick chawonongeka, chotsani ndi chatsopano.

Asanakhazikitse dongosolo la cartridge mu cholembera cha sytiit ya OptiClick, liyenera kukhala kutentha kwa firiji kwa maola 1-2. Njira yama cartridge iyenera kuyang'aniridwa isanayikidwe. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto ndipo lilibe zinthu zophatikizika. Pamaso jakisoni, thovu la mpweya liyenera kuchotsedwa mu dongosolo lama cartridge (lofanana ndi cholembera). Makina a cartridge opanda kanthu sagwiritsidwanso ntchito.

Ngati cholembera cha syringe sichili bwino, ngati kuli kotheka, insulini imatha kuperekedwa kwa wodwala polemba yankho kuchokera ku cartridge mu syringe ya pulasitiki (yoyenera insulini pochitika 100 IU / ml).

Popewa matenda, munthu m'modzi yekha ndi amene ayenera kugwiritsa ntchito cholembera.

Lantus SoloStar iyenera kuyendetsedwa mosavomerezeka kamodzi patsiku nthawi ina iliyonse, koma tsiku lililonse nthawi imodzi.

Odwala omwe ali ndi matenda a shuga 2, Lantus SoloStar angagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza mankhwala ena a hypoglycemic. Zolinga zakukula kwa glucose m'magazi, komanso Mlingo ndi nthawi ya makonzedwe a mankhwala a hypoglycemic ziyenera kutsimikizika ndikusintha payekhapayekha.

Kusintha kwa magazi kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwalayo, moyo wawo, kusintha nthawi ya makulidwe a insulin, kapena mikhalidwe ina yomwe ingalimbikitse chidwi chakukula kwa hypo- kapena hyperglycemia. Kusintha kulikonse kwa insulin kuyenera kuchitika mosamala komanso moyang'aniridwa ndi achipatala.

Lantus SoloStar si insulin yosankha yochizira matenda ashuga ketoacidosis. Pankhaniyi, kukondera kuyenera kuperekedwa / pakubweretsa insulin yochepa. Mu mankhwalawa othandizira kuphatikiza jakisoni wa basal ndi prandial insulin, 40-60% ya mlingo wa insulin tsiku lililonse wa insulin glargine nthawi zambiri amatumizidwa kuti akwaniritse zosowa za insulin.

Odwala omwe ali ndi matenda a shuga 2 amwa mankhwalawa amamwa mankhwala a hypoglycemic pakamwa, kuphatikiza mankhwalawa kumayamba ndi mlingo wa insulin glargine 10 PESCES 1 nthawi patsiku ndipo njira yotsatira yamankhwala imasinthidwa payekhapayekha.

Kwa odwala onse omwe ali ndi matenda ashuga, kuyang'anira kuwunika kwa shuga m'magazi kumalimbikitsidwa.

Kusintha kuchokera ku chithandizo ndi mankhwala ena a hypoglycemic kupita ku Lantus SoloStar

Posamutsa wodwala ku njira yochiritsira yogwiritsa ntchito nthawi yayitali kapena insulini yodwala pakanthawi kogwiritsira ntchito Lantus SoloStar, zingakhale zofunikira kusintha kuchuluka kwake (kuchuluka) ndi nthawi ya makulidwe a insulin yocheperako kapena analogue yake masana kapena kusintha Mlingo wamankhwala osokoneza bongo a hypoglycemic.

Posamutsa odwala kuchokera jakisoni imodzi ya insulin-isofan patsiku kupita ku mankhwala amodzi masana, Lantus SoloStar samasintha kawirikawiri mlingo woyambirira wa insulin (i., Kuchuluka kwa Lantus SoloStar Units patsiku lofanana ndi kuchuluka kwa IN insulin isofan patsiku).

Posamutsa odwala kuti atumize insulin-isophan kawiri masana kuti apange jekeseni imodzi ya Lantus SoloStar asanagone kuti achepetse vuto la hypoglycemia usiku ndi m'mawa kwambiri, mankhwalawa a insulin glargine nthawi zambiri amachepetsedwa ndi 20% (poyerekeza ndi insulin ya tsiku ndi tsiku isophane), kenako imasinthidwa malinga ndi yankho la wodwalayo.

Lantus SoloStar sayenera kusakanikirana kapena kuchepetsedwa ndi mankhwala ena a insulin. Onetsetsani kuti ma syringe alibe zotsalira zamankhwala ena. Mukasakaniza kapena kuchepetsera, mawonekedwe a insulin glargine amatha kusintha pakapita nthawi.

Posintha kuchokera ku insulin ya anthu kupita ku mankhwala a Lantus SoloStar komanso milungu yoyambirira itatha, kuyang'aniridwa mosamala kwa kagayidwe kamwazi m'magazi) moyang'aniridwa ndi achipatala akulimbikitsidwa, ndikuwongolera mlingo wa insulin ngati pakufunika. Monga ma fanizo ena a insulin yaumunthu, izi ndizofunikira kwambiri kwa odwala omwe, chifukwa cha kupezeka kwa ma antibodies a insulin ya anthu, ayenera kugwiritsa ntchito Mlingo waukulu wa insulin ya anthu. Odwala awa, akamagwiritsa ntchito insulin glargine, kusintha kwakukulu pamachitidwe a insulin kumawonekera.

Ndi bwino kagayidwe kachakudya ndi kuchuluka kwa minyewa kumva insulin, pangafunikire kusintha mlingo wa insulin.

Kusakaniza ndi kuswana

Mankhwala Lantus SoloStar sayenera kusakanikirana ndi ma insulini ena. Kusakaniza kungasinthe kuchuluka kwa nthawi / mphamvu ya mankhwala Lantus SoloStar, komanso kutsogolera ku mpweya.

Magulu apadera a odwala

Mankhwala Lantus SoloStar angagwiritsidwe ntchito mwa ana okulirapo zaka 2. Ntchito ana osaposa zaka 2 sizinaphunzire.

Kwa odwala okalamba omwe ali ndi matenda a shuga, ndikulimbikitsidwa kugwiritsa ntchito Mlingo woyambirira, kuwonjezereka kwawo pang'onopang'ono komanso kugwiritsa ntchito Mlingo wowonjezera.

Mankhwala Lantus SoloStar amaperekedwa ngati jakisoni wa sc. Mankhwala Lantus SoloStar silinapangidwe kuti likhale ndi mtsempha wowonjezera.

Kutalika kwazinthu zambiri za insulin glargine zimawonedwa pokhapokha ngati zimayambitsidwa ndi mafuta osaneneka. Mu / kumayambiriro kwa chizolowezi subcutaneous mlingo zingayambitse kwambiri hypoglycemia. Lantus SoloStar iyenera kuyambitsidwa mu mafuta ochulukitsa a m'mimba, mapewa kapena m'chiuno. Masamba a jakisoni amayenera kusinthana ndi jakisoni aliyense watsopano m'malo omwe akutsimikizidwira mankhwala a sc. Monga momwe zimakhalira ndi mitundu ina ya insulini, kuchuluka kwa mayamwidwe, ndipo, chifukwa, zoyambira ndi nthawi yake yochitikira, zimatha kusiyanasiyana mothandizidwa ndi zochitika zolimbitsa thupi komanso kusintha kwina kwa wodwalayo.

Lantus SoloStar ndi yankho lomveka bwino, osati kuyimitsidwa. Chifukwa chake, kupumulanso musanagwiritse ntchito sikofunikira. Pakasokonekera cholembera cha Lantus SoloStar, insulin glargine imatha kuchotsedwa mu katiriji mu syringe (yoyenera insulin 100 IU / ml) ndipo jakisoni wofunikira ukhoza kupangidwa.

Malamulo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar

Asanayambe kugwiritsa ntchito, cholembera cha syringe chimasungidwa kutentha kwa firiji kwa maola 1-2.

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi.

Ma syringe a SoloStar opanda kanthu sayenera kugwiritsidwanso ntchito ndipo ayenera kutayidwa.

Popewa matenda, cholembera chodzaza chisanachitike chizingogwiritsidwa ntchito ndi wodwala m'modzi ndipo sayenera kusamutsidwira wina.

Musanagwiritse ntchito cholembera cha SoloStar, werengani mosamala zidziwitso pakugwiritsa ntchito.

Musanagwiritse ntchito, gwiritsani ntchito singano yatsopano ndi cholembera chonde ndikuyesani mosamala. Ma singano okhawo omwe amagwirizana ndi SoloStar ayenera kugwiritsidwa ntchito.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso mwayi wopatsira matenda.

Palibe chifukwa chomwe muyenera kugwiritsira ntchito cholembera cha SoloStar ngati chawonongeka kapena ngati mukukayikira kuti chitha kugwira ntchito moyenera.

Muyenera kukhala ndi cholembera cha syringe ya SoloStar nthawi zonse ngati mungataye kapena kuwononga cholembera cha SoloStar.

Ngati cholembera cha SoloStar sichisungidwa mufiriji, chizichotsa maola awiri jekeseni isanachitike kuti yankho lithe kutentha. Makamaka insulini yodziwika bwino imapweteka kwambiri. Cholembera cha SoloStar chogwiritsidwa ntchito chimayenera kuwonongeka.

SoloStar syringe cholembera iyenera kutetezedwa kufumbi ndi litsiro. Kunja kwa cholembera cha SoloStar kumatha kutsukidwa ndikukupukuta ndi nsalu yonyowa. Osamiza m'madzi, kutsuka ndikuphika cholembera cha SoloStar, chifukwa izi zitha kuwononga.

Cholembera cha SoloStar chimatulutsa bwino insulin ndipo ndi chida kugwiritsa ntchito. Zimafunikanso kusamala mosamala. Pewani zochitika zomwe zingawononge cholembera cha SoloStar. Ngati mukukayikira kuwonongeka kwa cholembera cha SoloStar, gwiritsani ntchito cholembera chatsopano.

Gawo 1. Kuwongolera kwa insulin

Muyenera kuyang'ana cholembera pa cholembera cha SoloStar kuti mutsimikizire kuti ili ndi insulin yoyenera. Kwa Lantus, cholembera cha syloge ya SoloStar imakhala imvi ndi batani lofiirira pobayira. Pambuyo pochotsa kapu ya cholembera, ma insulini omwe ali momwemo amawongolera: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, losakhala ndi tinthu tolimba tomwe timakhala ngati madzi.

Gawo 2. Kulumikiza singano

Ma singano okhawo omwe amagwirizana ndi cholembera cha SoloStar ndi omwe akuyenera kugwiritsidwa ntchito.Pa jakisoni wotsatira, gwiritsani ntchito singano yatsopano yosabala. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

Gawo 3. Kuchita mayeso a chitetezo

Pamaso pa jekeseni iliyonse, ndikofunikira kuyeserera chitetezo ndikuonetsetsa kuti cholembera ndi singano zimagwira bwino komanso thovu lakum air limachotsedwa.

Muyezo Mlingo wofanana magawo awiri.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa.

Ikani cholembera ndi singano kumtunda, ikani pang'onopang'ono katoni ya insulini ndi chala chanu kuti thovu lonse lakumwamba litayendetsedwe ku singano.

Kanikizani bwino batani la jakisoni.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siziwoneka pamphepete mwa singano, ndiye kuti gawo 3 limatha kubwerezedwanso mpaka insulini ikawonekera pamsonga pa singano.

Gawo 4. Kusankha Mafuta

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 unit kuyambira pa mlingo wochepa (1 unit) mpaka mlingo waukulu (80 magawo). Ngati kuli koyenera kukhazikitsa mlingo wowonjezera wamagulu a 80, jakisoni wa 2 kapena kupitilira aperekedwe.

Zenera la dosing liyenera kuwonetsa "0" ndikamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

Gawo 5. Mlingo

Wodwala ayenera kudziwitsidwa za njira ya jakisoni ndi katswiri wazachipatala.

Singano iyenera kuyikiridwa pansi pa khungu.

Batani la jakisoni liyenera kukanikizidwa kwathunthu. Imachitika pamalo amenewa kwa masekondi 10 mpaka singano itachotsedwa. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

Gawo 6. Kuchotsa ndi kutaya singano

Mulimonsemo, singano pambuyo pa jekeseni aliyense ayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Pochotsa ndi kutaya singano, muyenera kusamala mosamala. Tsatirani njira zoyenera zotetezera pochotsa ndi singano (mwachitsanzo, njira ya dzanja limodzi) kuti muchepetse ngozi za ngozi zogwirizana ndi singano komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ndi kapu.

Zotsatira zoyipa

• hypoglycemia - imayamba kumachitika pafupipafupi ngati mlingo wa insulin uposa kufunika kwake,
• kuzindikira "kutada" kapena kuwonongeka kwake,
• wodwala matenda opatsirana
• njala
• kusakhazikika
• thukuta lozizira
• tachycardia
• kuwonongeka kwamawonekedwe
• retinopathy
• lipodystrophy,
• dysgeusia,
• myalgia
• kutupa
• Matupi awo sagwirizana ndi insulin (kuphatikizapo insulin glargine) kapena magawo othandizira a mankhwalawa: khungu limakhudzanso, angioedema, bronchospasm, ochepa hypotension, mantha,
• redness, kupweteka, kuyabwa, ming'oma, kutupa kapena kutupa pamalo a jekeseni.

Contraindication

• zaka za ana mpaka zaka 6 za Lantus OptiSet ndi OptiKlik (pakadali pano palibe zambiri zakugwiritsa ntchito)
• zaka za ana mpaka zaka 2 za Lantus SoloStar (kusowa kwa chidziwitso cha chipatala pakugwiritsa ntchito),
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mosamala, Lantus iyenera kugwiritsidwa ntchito panthawi yapakati.

Kwa odwala omwe ali ndi vuto la matenda am'mbuyomu kapena gestational shuga, ndikofunikira kuti azikhala ndi nthawi yokwanira yogwiritsira ntchito metabolism. Mu nyengo ya 1 ya mimba, kufunika kwa insulin kumatha kuchepa, mu 2nd ndi 3 trimesters ikhoza kukulira. Amayi akangobadwa kumene, kufunika kwa insulini kumachepa, chifukwa chake chiopsezo chokhala ndi hypoglycemia chikuwonjezeka. Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

M'maphunziro oyesera a nyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic of insulin glargine.

Sipanakhalepo mayesedwe azachipatala a chitetezo cha mankhwala Lantus panthawi yapakati. Pali umboni wa kugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandiranso kukonzekera kwina kwa insulin.

Amayi pakuyamwitsa, kuwongolera kwa insulin dosing regimen ndi zakudya kungafunike.

Gwiritsani ntchito ana

Pakalipano palibe zambiri zamankhwala zomwe zimagwiritsidwa ntchito mwa ana ochepera zaka 6.

Gwiritsani ntchito odwala okalamba

Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Malangizo apadera

Lantus si mankhwala osankhidwa pochiza matenda ashuga a ketoacidosis. Zikatero, njira yolimbikira ya insulin yochepa imalimbikitsidwa.

Chifukwa chazocheperako ndi Lantus, sizinali zotheka kuwunika kuti magwiridwe ake ndi otetezeka pochiza odwala omwe ali ndi vuto la chiwindi kapena odwala omwe ali ndi kuperewera kwapakati kapena koopsa.

Odwala omwe ali ndi vuto laimpso, kufunika kwa insulini kumatha kuchepa chifukwa chakufooka kwa njira zake zowonongera. Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin.

Odwala omwe ali ndi vuto lalikulu la kuchepa kwa hepatic, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi biotransfform ya insulin.

Pankhani ya kusakwanitsa kuyang'anira kuchuluka kwa shuga m'magazi, komanso ngati pali chizolowezi chokhala ndi hypo- kapena hyperglycemia, musanapitirize kukonza mankhwala, ndikofunikira kuyang'ana kulondola kwa kutsata njira, mankhwala omwe makonzedwe a mankhwalawo amathandizira komanso njira ya jekeseni yothandiza sc. , poganizira zonse zomwe zimayambitsa.

Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira. Chifukwa cha kuchuluka kwa nthawi yomwe imagwira ntchito Lantus, munthu akuyenera kuyembekezera kuchepa kwa nthawi yayitali, pomwe m'mawa kwambiri izi zimachitika. Ngati hypoglycemia imapezeka mwa odwala omwe amalandila Lantus, mwayi wochepetsera kutuluka kwa hypoglycemia chifukwa cha nthawi yayitali ya insulin glargine uyenera kuganiziridwanso.

Odwala omwe ma episode a hypoglycemia atha kukhala ndi matendawo, kuphatikizapo ndi stenosis yayikulu yamitsempha yama ziwalo zam'mimba kapena ziwongo (chiopsezo cha matenda a mtima ndi matenda a chithokomiro), komanso odwala omwe ali ndi proliferative retinopathy, makamaka ngati salandira chithandizo cha kuchepa kwa khungu chifukwa cha kuchepa kwa masokonezo chifukwa cha hypoglycemia), kusamalidwa kwapadera kuyenera kuyang'aniridwa ndikuwunikidwa mosamala. shuga wamagazi.

Odwala ayenera kuchenjezedwa pazochitika zomwe zingayambitse kuchepa kwa ziwonetsero za hypoglycemia, kusatchulika kapena kusapezeka m'magulu ena omwe ali pachiwopsezo, monga:

• odwala omwe asintha kwambiri magazi a shuga,
• odwala omwe hypoglycemia imayamba pang'onopang'ono,
• odwala okalamba
• odwala a neuropathy
• odwala matenda ashuga a nthawi yayitali
• odwala omwe ali ndi mavuto amisala
• odwala omwe adachokera ku insulin ya nyama kupita ku insulin yaumunthu,
• odwala kulandira chithandizo chamankhwala ena ndi ena.

Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (kutayika kwa chikumbumtima) wodwala asanadziwe kuti akupanga hypoglycemia.

Masewera a hemoglobin atakhala abwinobwino kapena kuchepa kwambiri, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwodalirika kwa mankhwala a dosing, zakudya, ndi zakudya, kugwiritsa ntchito bwino insulin, komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia. Pamaso pa zinthu zomwe zimapangitsa chidwi cha hypoglycemia, makamaka kuyang'anitsitsa ndikofunikira, chifukwa kusintha kwa insulin kungafunike. Izi ndi monga:

• Kusintha kwa malo makonzedwe a insulin,
• kuchuluka kwa insulin (mwachitsanzo, mukamachotsa kupsinjika),
• zodabwitsa, zolimbitsa thupi kapena zotalika,
• Matenda oyamba limodzi ndi kusanza, kutsekula m'mimba,
• kuphwanya zakudya ndi zakudya,
• adadula chakudya
• kumwa mowa
• matenda ena osagwirizana ndi endocrine (mwachitsanzo, hypothyroidism, kusakwanira kwa adenohypophysis kapena adrenal cortex),
• chithandizo chamankhwala ena.

Mu matenda apakati, kuyamwa kwamphamvu kwa magazi pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya zakudya zochepa, ngakhale mutangodya zochepa kapena osadya, komanso kusanza. Odwala awa sayenera kusiya kuperekera insulin.

Kuyanjana kwa mankhwala

Oral hypoglycemic agents, ACE inhibitors, disopyramides, fibrate, fluoxetine, mao inhibitors, pentoxifylline, dextropropoxyphene, salicylates ndi sulfonamide antimicrobials amatha kupititsa patsogolo hypoglycemic zotsatira za insulin ndikuwonjezera kutanthauzira pakukula kwa hypoglycemia. Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Glucocorticosteroids (GCS), danazole, diazoxide, okodzetsa, glucagon, isoniazid, estrogens, progestogens, phenothiazine zotumphukira, somatotropin, sympathomimetics (mwachitsanzo epinephrine, salbutamol, terbutaline), mahomoni a chithokomiro, ) itha kuchepetsa hypoglycemic zotsatira za insulin. Ndi kuphatikiza uku, kusintha kwa insulin glargine kungafunike.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Lantus okhala ndi beta-blockers, clonidine, lithiamu salt, ethanol (mowa), kuwonjezeka ndi kuchepa kwa mphamvu ya insogulculin kumatha. Pentamidine ikaphatikizidwa ndi insulin imatha kuyambitsa hypoglycemia, yomwe nthawi zina imasinthidwa ndi hyperglycemia.

Pogwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo omwe ali ndi mtima wachifundo, monga beta-blockers, clonidine, guanfacine ndi reserpine, kuchepa kapena kusapezeka kwa zizindikiro za adrenergic antigenergic (activation ya amamvekere a dongosolo lamanjenje) ndi kukula kwa hypoglycemia ndikotheka.

Lantus sayenera kusakanikirana ndi insulin ina yokonzekera, ndi mankhwala ena aliwonse, kapena kuchepetsedwa. Mukasakanikirana kapena kuchepetsedwa, mawonekedwe amachitidwe ake amatha kusintha pakapita nthawi, kuphatikiza, kusakanikirana ndi ma insulin ena kungayambitse mpweya.

Mndandanda wa mankhwala Lantus

Zofanana muzochitika zamagulu:

• Insulin glargine,
• Lantus SoloStar.

Analogs kwa achire zotsatira (mankhwalawa zochizira insulin-wodwala matenda a shuga):

• Khalid
• Anvistat
• Apidra
• B. Insulin
• Berlinulin,
• Biosulin
• Glyformin
• Glucobay,
• Depot insulin C,
• Dibikor
• Isofan Insulin World Cup,
• Iletin
• Insulin Isofanicum,
• Tepi ya insulin,
• Insulin Maxirapid B,
• Insulin sungunuka
• Insulinnt
• Insulin Ultralente,
• Insulin yayitali
• Insulin Ultralong,
• Insuman
• Pakati
• Comb-insulin C
• Levemir Penfill,
• Levemir Phukira,
• Metformin
• Mikstard
• Monosuinsulin MK,
• Monotard
• NovoMiks,
• NovoRapid,
• Pensulin,
• Protafan
• Rinsulin
• Stylamine
• Thorvacard
• Tricor
• Ultratard
• Humalog,
• Humulin,
• Cigapan
• Erbisol.

Zotsatira za pharmacological

Insulin glargine ndi insulin analogue yomwe imatenga nthawi yayitali kupezananso ndi mabakiteriya a DNA a mtundu wa Escherichia coli (tizilombo ta K12). Imakhala ndi solubility yochepa m'malo osalowerera ndale. Monga gawo la Lantus® SoloStar®, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe acidic yankho la jakisoni (pH = 4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitates, omwe ma insulin glargine amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda).

Magawo omangira a insulin zolandilira za insulin glargine ndi insulin ya anthu ali pafupi kwambiri, chifukwa chake, insulin glargine imakhala ndi chilengedwe chofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini ndikukhazikitsidwa kwa kagayidwe ka glucose. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kuchita kwa insulin glargine nthawi yayitali makamaka chifukwa cha kuchepa kwake, komwe kumakuthandizani kuti mugwiritse ntchito mankhwalawa 1 nthawi / Pambuyo pa utsogoleri wa sc, kuyambika kwa zochita zake kumawonedwa, pafupifupi, pambuyo pa ola 1. Nthawi yayitali yochita ndi maola 24, okwera ndi maola 29. Kutalika kwa insulin ndi mayendedwe ake (mwachitsanzo, insulin glargine) amatha kusiyanasiyana kwa odwala osiyanasiyana komanso kwa wodwala yemweyo.

Pharmacokinetics

Kafukufuku wofananira wa kutsindika kwa insulin glargine ndi insulin-isofan pambuyo pa sc pakubwera m'magazi a anthu athanzi komanso odwala matendawa adawonetsa kuyamwa pang'onopang'ono komanso kwa nthawi yayitali, komanso kusapezeka kwa nsonga ya insulin glargine poyerekeza ndi insulin-isofan.

Ndi subcutaneous makonzedwe a mankhwala 1 nthawi patsiku, khola ambiri insulin glargine mu magazi zimatheka pambuyo 2-4 masiku tsiku lililonse makonzedwe.

Ndi on / kumayambiriro kwa T1 / 2 insulin glargine ndi insulin yaumunthu ikufanana.

Mwa munthu yemwe wakula mafuta osunthika, insulin glargine imakhazikika pang'ono kuchokera kumapeto kwa carboxyl (C-terminus) ya B unyolo (beta unyolo) kuti ipange 21A-Gly-insulin ndi 21A-Gly-des-30B-Thr-insulin. Mu plasma, onse insulin glargine osasinthika ndi zopangidwa ndi cleavage zilipo.

Mlingo

Kwa akulu ndi ana opitilira zaka 6, mankhwalawa amathandizidwa kamodzi kamodzi patsiku, nthawi zonse. Lantus® SoloStar ® iyenera kupakidwa mafuta ochulukitsa a m'mimba, phewa kapena ntchafu. Maselo a jakisoni amayenera kusinthana ndi mtundu uliwonse wa mankhwala omwe ali mkati mwa malo omwe akulimbikitsidwa kuti apatsidwe mankhwala.

Mlingo wa mankhwalawa komanso nthawi yakatsiku la kasamalidwe ake imayikidwa payekhapayekha.Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, Lantus® SoloStar ® angagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza mankhwala ena a hypoglycemic.

Kusintha kuchokera ku chithandizo ndi mankhwala ena a hypoglycemic kupita ku Lantus® SoloStar ®

Mukasamutsa wodwala kuchokera kwautali kapena wapakati-nthawi yolumikizira ku Lantus® SoloStar ®, zingakhale zofunikira kusintha tsiku ndi tsiku momwe insal insulin kapena kusintha ochiritsira antidiabetesic mankhwala (Mlingo ndi njira yothandizira makonzedwe achidule a insulin kapena ma analogues awo, komanso Mlingo wa mankhwala opatsirana pakamwa).

Mukasamutsa wodwala kuchokera ku insulin-isofan-kawiri kukakhala kamodzi kwa mankhwala a Lantus® SoloStar ®, mlingo wa tsiku ndi tsiku wa insal insulin uyenera kuchepetsedwa ndi 20-30% m'milungu yoyamba yamankhwala kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri. Munthawi imeneyi, kuchepa kwa mulingo wa Lantus kuyenera kulipidwa ndi kuwonjezeka kwa Mlingo wa insulin yochepa, kenako ndikusintha kwa Mlingo wa mankhwala.

Monga ma fanizo ena a insulin yaumunthu, odwala omwe amalandira Mlingo wambiri wa mankhwala chifukwa cha kupezeka kwa ma antibodies kwa insulin ya anthu amatha kuwona kuwonjezeka kwa kuyankha kwa insulin pamene akusinthana ndi Lantus® SoloStar ®. Mukusintha kupita ku Lantus® SoloStar ® ndipo milungu yoyamba itatha, kuyang'anitsitsa shuga wa magazi ndikofunikira ndipo ngati pakufunika kutero, muyeso wa insulin dosing regimen.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha kulemera kwa thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena ngati zinthu zina zikuwoneka kuti zikuwonjezera kukonzekera kwa hypo- kapena hyperglycemia.

Mankhwalawa sayenera kuperekedwa kudzera m'mitsempha. Mu / pakubweretsa njira yanthawi zonse yokhazikitsidwa ndi subcutaneous makonzedwe, angayambitse kukula kwa hypoglycemia.

Lantus® SoloStar® sayenera kusakanikirana ndi insulin ina yokonzekera kapena kuchepetsedwa. Onetsetsani kuti ma syringe alibe zotsalira zamankhwala ena. Mukasakaniza kapena kuchepetsera, mawonekedwe a insulin glargine amatha kusintha pakapita nthawi. Kusakanikirana ndi ma insulin ena kumatha kupangitsa kuti mpweya uchitike.

Kutalika kwa mankhwala Lantus® SoloStar ® zimatengera kutengera kwa malo ake a sc.

Malamulo ogwiritsira ntchito ndi kusamalira cholembera chodzaza ndi SoloStar®

Asanayambe kugwiritsa ntchito, cholembera cha syringe chimasungidwa kutentha kwa firiji kwa maola 1-2.

Musanagwiritse ntchito, yang'anani cartridge mkati mwa cholembera. Iyenera kugwiritsidwa ntchito pokhapokha yankho likakhala lowonekera, lopanda utoto, lilibe tinthu tolimba tomwe timayimira, ndikufanana, madzi.

Ma syringe a Emplo SoloStar ® sayenera kugwiritsidwanso ntchito ndipo ayenera kutayidwa.

Popewa matenda, cholembera chodzaza chisanachitike chizingogwiritsidwa ntchito ndi wodwala m'modzi ndipo sayenera kusamutsidwira wina.

Musanagwiritse ntchito SoloStar ® Syringe pen, werengani mosamala zidziwitso zogwiritsira ntchito.

Musanagwiritse ntchito, gwiritsani ntchito singano yatsopano ndi cholembera chonde ndikuyesani mosamala. Ma singano okhawo omwe amagwirizana ndi SoloStar ® ndi omwe ayenera kugwiritsidwa ntchito.

Malangizo apadera amayenera kuchitika popewa ngozi zokhudzana ndi kugwiritsa ntchito singano komanso mwayi wopatsira matenda.

Palibe chifukwa chomwe muyenera kugwiritsira ntchito cholembera cha SoloStar ® ngati chawonongeka kapena ngati mukukayikira kuti chitha kugwira ntchito moyenera.

Nthawi zonse khalani ndi cholembera cha SoloStar ® chopopera pokhapokha mutataya kapena kuwononga cholembera cha SoloStar®.

Ngati cholembera cha SoloStar ® chikusungidwa mufiriji, chikuyenera kuchotsedwa maola 1-2 isanachitike jakisoni wofunikayo kuti yankho lithe kutentha. Makamaka insulini yodziwika bwino imapweteka kwambiri. Cholembera cha SoloStar ® Syringe chikuyenera kuwonongeka.

SoloStar® syringe cholembera iyenera kutetezedwa kufumbi ndi fumbi. Kunja kwa SoloStar® Syringe cholembera kumatha kutsukidwa ndikumupukuta ndi nsalu yonyowa. Osamiza m'madzimadzi, muzimutsuka ndikudzoza cholembera cha SoloStar ®, chifukwa izi zitha kuwononga.

SoloStar Syrrrr Syringe pen imapereka moyenera insulini ndipo ndi yoyenera kugwiritsa ntchito. Zimafunikanso kusamala mosamala. Pewani zochitika zomwe zowonongeka mu SoloStar® Syringe pen zingachitike. Ngati mukukayikira kuwonongeka kwa cholembera cha SoloStar ®, gwiritsani ntchito cholembera chatsopano.

Gawo 1. Kuwongolera kwa insulin

Muyenera kuyang'anitsitsa cholembera pa SoloStar® Syringe pen kuti muwonetsetse kuti ili ndi insulin yolondola. Kwa Lantus, cholembera cha syloge ya SoloStar ® imakhala imvi ndi batani lofiirira pakubaya. Pambuyo pochotsa kapu ya cholembera, ma insulini omwe ali momwemo amawongolera: yankho la insulini liyenera kukhala lowonekera, lopanda utoto, losakhala ndi tinthu tolimba tomwe timakhala ngati madzi.

Gawo 2. Kulumikiza singano

Ma singano okhawo omwe amagwirizana ndi SoloStar® Syringe pen ayenera kugwiritsidwa ntchito. Pa jakisoni wotsatira, gwiritsani ntchito singano yatsopano yosabala. Pambuyo pochotsa chipewa, singano iyenera kuyikiridwa mosamala pa cholembera.

Gawo 3. Kuchita mayeso a chitetezo

Pamaso pa jekeseni iliyonse, ndikofunikira kuyeserera chitetezo ndikuonetsetsa kuti cholembera ndi singano zimagwira bwino komanso thovu lakum air limachotsedwa.

Muyezo Mlingo wofanana magawo awiri.

Zingano zakunja ndi zamkati zimayenera kuchotsedwa.

Ikani cholembera ndi singano kumtunda, ikani pang'onopang'ono katoni ya insulini ndi chala chanu kuti thovu lonse lakumwamba litayendetsedwe ku singano.

Kanikizani bwino batani la jakisoni.

Ngati insulini ikuwonekera pachimake pa singano, izi zikutanthauza kuti cholembera ndi singano zikugwira ntchito moyenera.

Ngati insulini siziwoneka pamphepete mwa singano, ndiye kuti gawo 3 limatha kubwerezedwanso mpaka insulini ikawonekera pamsonga pa singano.

Gawo 4. Kusankha Mafuta

Mlingo ukhoza kukhazikitsidwa ndikulondola kwa 1 unit kuyambira pa mlingo wochepa (1 unit) mpaka mlingo waukulu (80 magawo). Ngati kuli koyenera kukhazikitsa mlingo wowonjezera wamagulu a 80, jakisoni wa 2 kapena kupitilira aperekedwe.

Zenera la dosing liyenera kuwonetsa "0" ndikamaliza kuyesa kwa chitetezo. Pambuyo pake, mlingo wofunikira ukhoza kukhazikitsidwa.

Gawo 5. Mlingo

Wodwala ayenera kudziwitsidwa za njira ya jakisoni ndi katswiri wazachipatala.

Singano iyenera kuyikiridwa pansi pa khungu.

Batani la jakisoni liyenera kukanikizidwa kwathunthu. Imachitika pamalo amenewa kwa masekondi 10 mpaka singano itachotsedwa. Izi zimathandizira kuyambitsa mtundu wa insulin kwathunthu.

Gawo 6. Kuchotsa ndi kutaya singano

Mulimonsemo, singano pambuyo pa jekeseni aliyense ayenera kuchotsedwa ndikuchotsedwa. Izi zimathandizira kupewa kuipitsidwa ndi / kapena kutenga kachilomboka, kulowa mu chidebe cha insulin ndi kutulutsa insulin.

Pochotsa ndi kutaya singano, muyenera kusamala mosamala. Tsatirani njira zoyenera zotetezera pochotsa ndi singano (mwachitsanzo, njira ya dzanja limodzi) kuti muchepetse ngozi za ngozi zogwirizana ndi singano komanso kupewa matenda.

Mukachotsa singano, tsekani cholembera cha SoloStar ® ndi chipewa.

Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Lantus olowa m'malo, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa komanso momwe mungagwiritsire ntchito

Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?

Kuti mupeze analogue yotsika mtengo kwa mankhwala, a generic kapena ofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezi zomwe zikugwiritsidwa ntchito ndikuwonetsa. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Malangizo a Lantus

Chiyimilira cha Sanofi-aventis Gulu Joint-Stock Company (France)

subcutaneous solution 100 IU / ml, 3 ml cartridge, Optiklik 5 cartridge system, Cardboard pack 1, EAN code: 4030685479170, No. P N014855 / 01, 2006-07-21 kuchokera ku Aventis Pharma Deutschland GmbH (Germany), Yotayika tsiku lomaliza 2009-01-28

Mankhwala

Insulin glargine ndi analogue ya insulin ya anthu, yodziwika ndi otsika solubility m'malo osagwirizana nawo. Monga gawo lakukonzekera kwa Lantus, imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi chilengedwe cha acidic yankho la jakisoni (pH4). Pambuyo poyambitsa mafuta ochulukirapo, yankho, chifukwa cha acidity yake, limalowa mu mawonekedwe osakanikirana ndi mapangidwe a microprecipitate, pomwe ma insulin glargine amatulutsidwa, kupereka chithunzithunzi chosavuta, chosapendekeka (chopanda).

Kulumikizana ndi insulin receptors: magawo omangirizira enieni a insulin glargine ndi ma insulin receptor a anthu ali pafupi kwambiri, ndipo amatha kuyanjana ndi kwachilengedwenso zotsatira zofanana ndi insulin.

Chochita chofunikira kwambiri cha insulini, motero insulin glargine, ndikuyang'anira kagayidwe ka shuga. Insulin ndi mawonekedwe ake amachepetsa shuga m'magazi ndikulimbikitsa kukoka kwa glucose pogwiritsa ntchito zotumphukira (makamaka mafupa a minofu ndi adipose minofu), komanso kuletsa mapangidwe a shuga mu chiwindi (gluconeogenesis). Insulin imalepheretsa adipocyte lipolysis ndi proteinol, pamene ikupanga kuphatikiza mapuloteni.

Kutalika kwa nthawi yayitali ya insulin glargine imakhudzana makamaka ndi kuchepetsedwa kwa mayamwidwe ake, omwe amalola kuti mankhwalawa azigwiritsidwa ntchito kamodzi patsiku. Pambuyo pa utsogoleri wa sc, kuyamba kwa zochita kumachitika, pafupifupi, pambuyo pa ola 1. Nthawi yayitali yochita ndi maola 24, okwera ndi maola 29.

Mimba komanso kuyamwa

M'maphunziro a zinyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic zotsatira za insulin glargine.

Mpaka pano, palibe ziwerengero zoyenera zogwiritsira ntchito mankhwalawa panthawi yapakati. Pali umboni wa kugwiritsa ntchito kwa Lantus mwa azimayi 100 oyembekezera omwe ali ndi matenda ashuga. Maphunziridwe ake ndi zotsatira za kutenga pakati pa odwalawa sizinasiyanane ndi zomwe zimachitika mwa amayi apakati omwe ali ndi matenda ashuga omwe amalandiranso kukonzekera kwina kwa insulin.

Kukhazikitsidwa kwa Lantus mwa amayi apakati kuyenera kuchitika mosamala. Kwa odwala omwe ali ndi matenda osokoneza bongo omwe alipo kale kapena a gestationalabetes mellitus, ndikofunikira kuti azitha kuyang'anira machitidwe a metabolic panthawi yonse yovomerezeka. Kufunika kwa insulin kumatha kuchepa mu trimester yoyamba ya kutenga pakati ndikuwonjezeka panthawi yachiwiri komanso yachitatu. Pambuyo pobadwa, kufunika kwa insulini kumachepera msanga (chiopsezo cha hypoglycemia chikuwonjezeka). Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

Mwa kuyamwa azimayi, mlingo wa insulini komanso kusintha kwa zakudya kungafunike.

Zotsatira zoyipa

Hypoglycemia - zotsatira zoyipa kwambiri za insulin mankhwala zimatha kuchitika ngati mlingo wa insulin ndiwokwera kwambiri poyerekeza ndi kufunika kwake. Kuukira kwa hypoglycemia, makamaka kubwereza, kungayambitse kuwonongeka kwamanjenje. Zolemba za hypoglycemia zomwe zimatenga nthawi yayitali komanso zimatha kuwononga miyoyo ya odwala. Zizindikiro za adrenergic counter-regulation (kutsegulira kwa dongosolo lachifundo poyankha hypoglycemia) nthawi zambiri zimayambitsa matenda a neuropsychiatric chifukwa cha hypoglycemia (chikumbumtima chamadzulo kapena kutayika kwake, matenda osokoneza bongo): njala, kusokonekera, thukuta lozizira, tachycardia (kufalikira msanga kwa hypoglycemia ndi ndicofunika kwambiri, zizindikilo zotchulidwa za adrenergic counterregulation).

Zochitika zoyipa kuchokera pamaso. Kusintha kwakukuru mu kayendedwe ka glucose m'magazi kungayambitse kuwonongeka kwakanthawi chifukwa cha kusintha kwa minofu ya turgor ndi index ya refractive ya lens yamaaso. Kutalika kwa nthawi yayitali kwamwazi wamagazi kumachepetsa chiopsezo cha kupitirira kwa matenda ashuga retinopathy. Mankhwala a insulin, limodzi ndi kusinthasintha kwamphamvu kwa shuga m'magazi, angayambitse kukulira kwakanthawi kwa matenda a shuga a retinopathy. Odwala omwe ali ndi prineticolin ambiri, makamaka omwe samalandira chithandizo cha photocoagulation, zochitika za kwambiri za hypoglycemia zingayambitse kukula kwamawonedwe kwakanthawi.

Lipodystrophy. Monga chithandizo china chilichonse cha insulin, lipodystrophy ndi kuchedwa kwakanthawi mayamwidwe / mayamwidwe a insulin kumatha kupezeka pamalo a jakisoni.M'mayesero azachipatala panthawi ya insulin mankhwala ndi Lantus, lipodystrophy imawonedwa mu 1-2% ya odwala, pomwe lipoatrophy nthawi zambiri anali osavomerezeka. Kusintha kosalekeza kwa malo a jekeseni mkati mwa thupi omwe amalimbikitsidwa kuti apangidwe ndi insulin kungathandize kuchepetsa kuopsa kwa izi kapena kupewa kukula kwake.

Zomwe zimachitika mdera lakayendetsedwe ka kayendetsedwe kake ndi zovuta zake. Panthawi ya mayesero azachipatala pa nthawi ya mankhwala a insulin omwe amagwiritsidwa ntchito ndi Lantus, zomwe zimachitika jakisoni jakisoni zinaonedwa mu 3-4% odwala. Zithunzizi zimaphatikizaponso kufiyira, kupweteka, kuyabwa, ming'oma, kutupa, kapena kutupa. Zochita zazing'ono zochepa zomwe zimachitika pamalo operekera insulin nthawi zambiri zimathetsa kwakanthawi kuchokera masiku angapo mpaka milungu ingapo. Thupi lawo siligwirizana kwenikweni hypersensitivity kwa insulin ndizosowa. Kuchita kotereku kwa insulin (kuphatikizapo insulin glargine) kapena kufufutidwa kutha kuwoneka ngati khungu limakhudza, angioedema, bronchospasm, ochepa hypotension kapena kugwedezeka, ndipo motero kutha kukhala pachiwopsezo cha moyo wa wodwalayo.

Zina. Kugwiritsa ntchito insulin kungayambitse kupanga kwa antibodies kwa izo. Panthawi ya mayesero azachipatala m'magulu a odwala omwe amathandizidwa ndi insulin-isofan ndi insulin glargine, mapangidwe a antibodies akuwombana ndi insulin yaumunthu amawonedwa pafupipafupi. Nthawi zina, kukhalapo kwa ma antibodies oterewa ku insulin kungapangitse kusintha kwa mankhwalawa kuti athetse chizolowezi chokhala ndi hypo- kapena hyperglycemia. Nthawi zambiri, insulini imapangitsa kuti kuchepa kwa mankhwala a sodium ndi mapangidwe a edema, makamaka ngati insulini yowonjezereka imabweretsa kusintha kosasintha kwa kayendedwe ka metabolic.

Kuchita

Mankhwala angapo amakhudza kagayidwe kakang'ono ka shuga, kamene kangafunike kusintha kwa insulin glargine.

Kukonzekera komwe kumathandizira hypoglycemic zotsatira za insulin ndikuwonjezera kutengera kwa chitukuko cha hypoglycemia kumaphatikizapo othandizira a hypoglycemic othandizira, ma inhibitors a ACE, disopyramides, fibrate, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, ma salicylates ndi sulfonamide antimicrobials. Mankhwala omwe amatha kufooketsa mphamvu ya hypoglycemic ya insulini amaphatikiza corticosteroids, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, gestagens, phenothiazine zotumphukira, somatotropin, sympathomimetics monga epinephrine (adrenaline), salbutamolum mapuloteni, ma antipsychotic ena (mwachitsanzo olanzapine kapena clozapine).

Beta-blockers, clonidine, mchere wa lithiamu kapena mowa amathanso kuwonjezera komanso kufooketsa mphamvu ya insulin.

Pentamidine imatha kuyambitsa hypoglycemia, yomwe nthawi zina imasinthidwa ndi hyperglycemia.

Kuphatikiza apo, mothandizidwa ndi mankhwala achifundo ngati a beta-blockers, clonidine, guanfacine ndi reserpine, zizindikiro za kutsutsana ndi adrenergic zitha kuchepetsedwa kapena kusapezeka.

Bongo

Zizindikiro kwambiri komanso nthawi yayitali hypoglycemia, kuwopseza moyo wa wodwalayo.

Chithandizo: magawo a hypoglycemia wolimbitsa thupi nthawi zambiri amayimitsidwa ndi kumeza chakudya cham'mimba chambiri. Pangakhale kofunikira kusintha mtundu wa mankhwala, zakudya kapena zolimbitsa thupi. Ndime za hypoglycemia yoopsa, yophatikizika ndi chikomokere, kukomoka kapena matenda amitsempha, amafunika kulowetsedwa kwamkati kapena glucagon, komanso kulowetsedwa kwa njira yokhazikika ya dextrose solution. Zakudya zamafuta nthawi yayitali komanso kuyang'aniridwa kwa akatswiri kungafunike, popeza hypoglycemia imatha kubwereranso pambuyo pakuwoneka kachipangidwe kazachipatala.

Malangizo apadera

Lantus si mankhwala osankhidwa pochiza matenda ashuga a ketoacidosis. Zikatero, iv ikulimbikitsidwa kuti ikhale ndi insulin yochepa. Chifukwa chazocheperako ndi Lantus, sizinali zotheka kuwunika kuti magwiridwe ake ndi otetezeka pochiza odwala omwe ali ndi vuto la chiwindi kapena odwala omwe ali ndi vuto lochepa kwambiri kapena laimpso. Odwala omwe ali ndi vuto laimpso, kufunika kwa insulini kumatha kuchepa chifukwa chakufooka kwa njira zake zowonongera. Mwa odwala okalamba, kuwonongeka kwa pang'onopang'ono mu ntchito ya impso kungayambitse kuchepa kwamphamvu kwa zofunikira za insulin. Odwala omwe ali ndi vuto lalikulu la kuchepa kwa hepatic, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi biotransfform ya insulin. Pankhani yoyendetsa bwino magazi pamagazi, komanso ngati pali chizolowezi chomanga matenda a hypo- kapena hyperglycemia, musanapitirize kukonza mankhwala, ndikofunikira kuwunika kulondola kwa kutsata njira, njira zoyendetsera mankhwalawa ndi njira ya jekeseni yothandiza, poganizira zinthu zonse zomwe zikugwirizana ndi vutoli.

Hypoglycemia. Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira. Chifukwa cha kuchuluka kwa nthawi yomwe zimatenga kuti insulin yayitali idze mthupi pogwiritsa ntchito Lantus, mwayi wokhala ndi nocturnal hypoglycemia umachepa, pomwe m'mawa izi zitha kuchuluka. Odwala omwe ma episode a hypoglycemia amatha kukhala ndi vuto la kuchipatala, monga odwala omwe ali ndi vuto lalikulu la mitsempha ya mitsempha kapena mitsempha ya m'magazi (chiopsezo cha matenda a mtima ndi matenda a hypoglycemia), komanso odwala omwe akukhala ndi prinogathy wambiri. kuchepa kwamono kwakanthawi chifukwa cha hypoglycemia), kusamalitsa kwapadera kuyenera kuonedwa, komanso kumalimbikitsidwanso kukulitsa kuwunika kwa magazi. Odwala ayenera kudziwa momwe zinthu zomwe zimasinthira hypoglycemia zimasinthira, kukhala osatchulika kapenanso kusapezeka m'magulu ena omwe ali pachiwopsezo. Maguluwa akuphatikizapo:

- odwala omwe asintha kwambiri magazi a shuga,

- odwala omwe hypoglycemia imayamba pang'onopang'ono,

- odwala okalamba,

- odwala neuropathy,

- odwala omwe ali ndi shuga yayitali,

- odwala omwe ali ndi mavuto amisala,

- odwala omwe amalandila chithandizo chamankhwala ena ndi ena (onani "Kuyanjana").

Zochitika zoterezi zimatha kuyambitsa kukula kwa hypoglycemia (kutayika kwa chikumbumtima) wodwala asanadziwe kuti akupanga hypoglycemia.

Poona kuti kuchuluka kwa hemoglobin yokhazikika kapena yafupika, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwa odwala ndi dongosolo la dosing, zakudya ndi zakudya, kugwiritsa ntchito bwino insulini komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia. Zinthu zomwe zimawonjezera kukonzekera kwa hypoglycemia zimafunikira kuwunikira mosamala, monga angafunikire kusintha kwa insulin. Izi ndi monga:

- kusintha kwa oyang'anira a insulin,

- kuchuluka kwa chidwi ndi insulin (mwachitsanzo, mukamachotsa kupsinjika),

- zachilendo, kuchuluka kapena zolimbitsa thupi nthawi yayitali,

- Matenda oyenda limodzi ndi kusanza, kutsekula m'mimba,

- kuphwanya zakudya ndi zakudya,

- kudumphika chakudya

- mavuto ena a endocrine osawerengeka (mwachitsanzo, hypothyroidism, kusakwanira kwa adenohypophysis kapena adrenal cortex),

- chithandizo chofanana ndi mankhwala ena.

Matenda apakati. Pa matenda oyanjana nawo, kuyang'anira kwambiri shuga pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu woyamba a shuga ayenera kupitiliza kudya zakudya zochepa, ngakhale atha kudya pang'ono kapena sangathe kudya, ngati akusanza, ndi zina zambiri. Odwala awa sayenera kusiya kuperekera insulin.

Mimba komanso kuyamwa

Zambiri zamankhwala pakugwiritsa ntchito insulin glargine mwa amayi apakati, omwe amapezeka panthawi yoyesedwa mwachipatala, palibe. Zochepa
mimba, komanso mkhalidwe wathanzi la mwana wosabadwa komanso wakhanda. Palibenso data yananso yofunika kwambiri.

M'maphunziro a zinyama, palibe deta yachindunji kapena yosalunjika yomwe idapezeka pa embryotoxic kapena fetotoxic zotsatira za insulin glargine. Kugwiritsa ntchito kwa Lantus pa nthawi ya pakati kungatengedwe ngati pakufunika.

Kwa odwala omwe ali ndi matenda osokoneza bongo omwe alipo kale kapena a gestationalabetes mellitus, ndikofunikira kuti azitha kuyendetsa bwino kagayidwe ka glucose panthawi yonse yovomerezeka. Kufunika kwa insulini kumatha kuchepa mu trimester yoyamba ya kutenga pakati, komanso, kuwonjezeka panthawi yachiwiri komanso yachitatu. Pambuyo pobadwa, kufunika kwa insulini kumachepera msanga (chiopsezo cha hypoglycemia chikuwonjezeka). Pansi pa izi, kuyang'anira shuga wamagazi ndikofunikira.

Sizikudziwika ngati insulin glargine imadutsa mkaka wa m'mawere. Palibe zoyipa za metabolic mutamwa insulin glargine mkati mwa makanda osayembekezereka, popeza, kukhala puloteni, insulin glargine imaphwanyidwa kukhala ma amino acid m'matumbo amunthu.

Povala mkaka, zingakhale zofunika kusintha mankhwalawa a insulin komanso zakudya.

Lantus ndi Tujeo: zosiyana ndi zofanana

Chimodzi mwazinthu zazikulu pakusankha mitundu ya insulin ndi chinthu monga kuthamanga kwa zotsatira zakepi. Mwachitsanzo, pali ena omwe amachita mwachangu kwambiri ndipo jakisoni amayenera kuchitidwa mphindi makumi atatu kapena makumi anayi asanadye.

Koma pali iwo omwe, m'malo mwake, ali ndi mphamvu yayitali kwambiri, nthawi imeneyi imatha kufikira maola khumi ndi awiri. Potsirizira pake, njira iyi ingapangitse kukula kwa hypoglycemia mu shuga mellitus.

Pafupifupi mitundu yonse yamakono ya insulini imagwira ntchito mwachangu. Wotchuka kwambiri ndi insulin yakwathupi, imagwira mphindi imodzi kapena yachisanu pambuyo pa jakisoni.

Mwambiri, ndikofunikira kuwunikira zotsatirazi zabwino za fanizo zamakono:

1. Mayankho osavomerezeka.
2. Mankhwalawa amapezeka pogwiritsa ntchito ukadaulo wamakono wama DNA.
3. Mafuta amakono a insulin ali ndi mankhwala atsopano.

Chifukwa cha zonse zomwe zili pamwambapa, zinali zotheka kukwanitsa bwino bwino pakati pa chiwopsezo chokhala ndi spikes mwadzidzidzi m'magawo a shuga ndikupeza zizindikiro za glycemic.

Mwa mankhwala odziwika amakono atha kudziwika:

• Analog ya ultrashort insulin, yomwe ndi Apidra, Humalog, Novorapid.
• Yaitali - Levemir, Lantus.

Wodwala akakhala ndi vuto lililonse pambuyo pa jakisoni, adokotala akuwonetsa kulowetsanso insulin.

Koma muyenera kuchita izi pokhapokha poyang'aniridwa ndi katswiri ndikuwonetsetsa momwe wodwalayo akusamalirani.

Kodi pali kusiyana kotani ndi Lantus, yemwe anali wodziwika ndi kufalitsidwa kale? Monga Lantus, mankhwalawa amapezeka mumachubu osavuta kugwiritsa ntchito.

Thumba lililonse limakhala ndi limodzi, ndipo kuti mugwiritse ntchito ndikwanira kutsegula ndikuchotsa kansalu ndikufinya dontho la zomwe zili ndi singano yomanga. Kugwiritsanso ntchito syringe chubu ndikotheka kokha asanachotsere injector.

Monga ku Lantus, ku Tujeo, chinthu chogwira ntchito ndi glargine - chithunzi cha insulin chopangidwa m'thupi la munthu. Glargine wophatikizika umapangidwa ndi njira ya kubwereza kwa DNA kwa mtundu wina wapadera wa Escherichia coli.

Mphamvu ya hypoglycemic imadziwika ndi kufanana komanso nthawi yayitali, yomwe imatheka chifukwa chotsatira njira ya thupi la munthu. Chithandizo chogwira ntchito cha mankhwalawa chimayambitsidwa ndi minofu yamafuta a anthu, pansi pa khungu.

Chifukwa cha izi, jakisoni amakhala wosapweteka komanso wosavuta kuchita.

Acidic solution ndi yotenga mbali, zomwe zimapangitsa kuti pakapangidwe michere yaying'ono yomwe imatha kumasula pang'onopang'ono ntchito.

Zotsatira zake, ndende ya insulin imakwera bwino, yopanda nsonga ndi madontho akuthwa, komanso kwanthawi yayitali. Kukhazikika kwa chochitika kumawonedwa pambuyo pa ola limodzi pambuyo pa jekeseni wa mafuta ochulukirapo. Kuchitikaku kumatha maola osachepera 24 kuyambira nthawi yoyang'anira.

Nthawi zina, Tujeo imakhala yowonjezereka mpaka maola 29 - 30. Nthawi yomweyo, kutsika kwamphamvu kwa glucose kumachitika pambuyo pa jakisoni a 3-4, ndiye kuti, palibe kale kuposa masiku atatu atayamba kumwa mankhwalawa.

Monga Lantus, gawo la insulin limasweka ngakhale isanalowe m'magazi, m'matumbo amafuta, motsogozedwa ndi ma asidi omwe amapezeka m'menemo. Zotsatira zake, pakuwunikira, deta imatha kupezeka pazowonjezera zomwe zimapangitsa insulini kusweka m'magazi.

Kusiyana kwakukulu kuchokera ku Lantus ndi kuchuluka kwa insulin yopanga muyezo umodzi wa Tujeo. Mukukonzekera kwatsopano, kumakhala katatu mwinanso 300 IU / ml. Chifukwa cha izi, kuchepa kwakukulu kwa kuchuluka kwa jakisoni tsiku ndi tsiku kumatheka.

Kuphatikiza apo, malinga ndi Sanofi, kuwonjezereka kwa mankhwalawa kunathandizira "kusalala" kwa mankhwalawa.

Chifukwa cha kuchuluka kwa nthawi pakati pa mabungwe, kuchepa kwakukulu kwa masheya a glargine kumatheka.

Ikagwiritsidwa ntchito moyenera, hypoglycemia imagwiritsidwa ntchito pokhapokha pokhapokha ngati pali mankhwala ena okhala ndi insulin ndikupita ku Tujeo. Pakadutsa masiku 7-10 atayamba kumwa hypoglycemia imakhala chinthu chosowa kwambiri komanso chaypypical ndipo imatha kuwonetsa kusankhidwa kwakanthawi kogwiritsa ntchito mankhwalawa.

Zowona, kuwonjezereka katatu kwa ndende kunapangitsa kuti mankhwalawo akhale osasinthasintha. Ngati Lantus angagwiritsidwe ntchito pa matenda ashuga mwa ana ndi achinyamata, ndiye kuti kugwiritsa ntchito Tujeo ndizochepa. Wopanga amalimbikitsa kuti azigwiritsa ntchito mankhwalawa kuyambira azaka 18 zokha.

Mlingo ndi makonzedwe

Mankhwala anaupanga subcutaneous makonzedwe.

Mankhwalawa sayenera kuperekedwa kudzera m'mitsempha. Kutalika kwa zochita za Lantus kumachitika chifukwa cha kuyambitsa kwake mu mafuta obisika. Mitsempha yoyeserera ya subcutaneous mlingo ingayambitse kwambiri hypoglycemia.

Palibe kusiyana kwazamankhwala mu seramu insulin kapena milingo ya shuga pambuyo pakukhazikitsidwa kwa Lantus kumafuta ochulukirapo a m'mimba, phewa, kapena ntchafu. Mu gawo lomwelo la kayendetsedwe ka mankhwala, ndikofunikira kusintha malo a jekeseni nthawi iliyonse.

Lantus imakhala ndi insulin glargine, yomwe imakhala nthawi yayitali insulin. Mankhwala amayenera kuperekedwa nthawi imodzi patsiku nthawi imodzi.

Mlingo wa Lantus ndi nthawi yakatsiku lakukhazikitsidwa kwake amasankhidwa payekha.Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri, Lantus angagwiritsidwe ntchito ngati monotherapy kapena kuphatikiza mankhwala ena a hypoglycemic.

Zochita za mankhwalawa zimafotokozedwa m'magawo (UNITS). Magawo awa amagwiritsidwa ntchito kokha ku Lantus: izi sizofanana ndi ziwalo zomwe zimagwiritsidwa ntchito kufotokoza zochita za ma insulin ena (onani Pharmacodynamics).

Okalamba (woposa zaka 65)

Odwala okalamba, kuwonongeka kwa impso kungapangitse kuchepa kwapang'onopang'ono kwa zofunika za insulin.

Odwala ndi mkhutu aimpso ntchito

Odwala omwe ali ndi vuto la impso, kufunika kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa insulin metabolism.

Odwala omwe ali ndi vuto la chiwindi

Kwa odwala omwe ali ndi vuto la chiwindi, kusowa kwa insulin kumatha kuchepetsedwa chifukwa cha kuchepa kwa mphamvu ya gluconeogeneis ndi insulin metabolism.

Chitetezo ndi ntchito ya Lantus® yakhazikitsidwa kwa achinyamata ndi ana opitilira zaka 2. Maphunziro a Lantus mwa ana osakwana zaka 2 sanachitike.

Kusintha kuchokera ku chithandizo ndi mankhwala ena a hypoglycemic kupita ku Lantus

Mukasinthira nthawi yayitali kapena yolimbitsa thupi pakakhala mankhwala a Lantus, zingakhale zofunikira kusintha tsiku ndi tsiku insulin, komanso zingakhale zofunikira kusintha njira yothandizirana ndi antidiabetic mankhwala (ma doses ndi makonzedwe a makina ogwiritsira ntchito mapiritsi osachepera kapena mapiritsi awo ochepetsa shuga. )

Posamutsa odwala kuti ayambe kutumiza NPH-insulin kawiri masana kupita kuntchito imodzi ya Lantus kuti muchepetse chiopsezo cha hypoglycemia usiku ndi m'mawa kwambiri, mlingo wa tsiku ndi tsiku wa basal insulin uyenera kuchepetsedwa ndi 20-30% milungu yoyamba.

Odwala omwe amalandira mlingo waukulu wa NPH-insulin, chifukwa cha kukhalapo kwa ma antibodies a insulin ya anthu akapita ku Lantus, kusintha poyankha kungatheke.

Pakusintha komanso m'masabata oyambilira, kuyang'anira shuga wamagazi ndikofunikira.

Pofuna kusintha kwa kagayidwe kazinthu komanso kuwonjezereka kwa chidwi cha insulin, kuwongolera kwina kwa mankhwalawa kungakhale kofunikira. Kusintha kwa mlingo kungafunikenso, mwachitsanzo, pakusintha thupi la wodwala, moyo, nthawi ya tsiku yoperekera mankhwala, kapena zina zikawoneka kuti zimathandizira kukulira kwa hypo- kapena hyperglycemia (onani malangizo apadera ndi njira zopewera kugwiritsa ntchito).

Mankhwala sayenera kusakanikirana ndi insulin ina yokonzekera kapena kuchepetsedwa. Mukasakanikirana kapena kuchepetsedwa, mawonekedwe amachitidwe ake amatha kusintha pakapita nthawi, kuphatikiza, kusakanikirana ndi ma insulin ena kungayambitse mpweya.

Musanagwiritse ntchito cholembera cha SoloStar®, muyenera kuwerenga mosamala malangizo kuti agwiritse ntchito.

Momwe mungagwiritsire ntchito mankhwala

Mankhwala amagwiritsidwa ntchito pa matenda a shuga, omwe amafunikira chithandizo ndi insulin. Nthawi zambiri imakhala mtundu woyamba wa shuga. Hormoni imatha kutumizidwa kwa odwala onse azaka zopitilira zisanu ndi chimodzi.

Kuchita insulin kwa nthawi yayitali ndikofunikira kuti magazi a wodwalayo azisala mwachangu. Munthu wathanzi m'magazi nthawi zonse amakhala ndi kuchuluka kwa mahomoni awa, zomwe zimakhala m'magazi zimatchedwa basal level.

Odwala omwe ali ndi matenda a shuga mellitus ngati ali ndi vuto la kapamba, pakufunika insulin, yomwe imayenera kuperekedwa nthawi zonse.

Njira ina yotulutsira mahomoni m'magazi imatchedwa bolus. Zimaphatikizidwa ndi kudya - poyankha kuwonjezeka kwa shuga wamagazi, insulini ina imatulutsidwa kuti mwachangu matenda a glycemia ayambe kudwala.

Mu shuga mellitus, ma insulin osakhalitsa amagwiritsidwa ntchito pamenepa.Pankhaniyi, wodwalayo amayenera kudziphatikiza ndi cholembera nthawi iliyonse atatha kudya, zomwe zimakhala ndi kuchuluka kwa mahomoni.

M'mafakitala, kuchuluka kwa mitundu yosiyanasiyana ya mankhwala othandizira matenda a shuga amagulitsidwa. Ngati wodwala akufunika kugwiritsa ntchito timadzi tambiri tomwe timapanga, ndiye kuti ndi bwino kugwiritsa ntchito - Lantus kapena Levemir? Munjira zambiri, mankhwalawa ndi ofanana - onse ndi ofunika, ndi olosera kwambiri komanso osasunthika pakugwiritsa ntchito.

Tiyeni tiwone momwe mahomoni awa amasiyanirana. Amakhulupilira kuti Levemir ali ndi moyo wautali kwambiri kuposa Lantus Solostar - mpaka masabata 6 motsutsana ndi mwezi umodzi. Chifukwa chake, Levemir amadziwika kuti ndiwothandiza kwambiri ngati mukufunikira kuti mupeze mankhwala ochepa, mwachitsanzo, kutsatira zakudya zamagulu ochepa.

Akatswiri akuti Lantus Solostar angakulitse chiopsezo cha khansa, koma palibe chodalirika pazomwezi.

Kodi pali kusiyana kotani pakati pa mankhwala?

Mankhwala ena amatha kuthana ndimatenda a shuga ndi insulin, omwe angafune kusintha kwa mankhwalawo komanso kusintha kwa muyezo wa Lantus insulin.

Kukonzekera kwotsatira kwamankhwala kungapangitse kwambiri zotsatira za insulin glargine:

• mankhwala antipyretic mankhwala:
• mankhwala omwe amalepheretsa zochitika za ACE,
• Disopyramide - mankhwala omwe amasintha kugunda kwa mtima,
• Fluoxetine - mankhwala ogwiritsidwa ntchito pamavuto akulu,
• kukonzekera komwe kumapangidwa pamaziko a fibroic acid,
• mankhwala omwe amaletsa ntchito ya monoamine oxidase,
• Pentoxifylline - mankhwala a gulu la angioprotectors,
• Propoxifene ndi mankhwala osokoneza bongo osokoneza bongo,
• salicylates ndi sulfonamides.

Mankhwala otsatirawa amatha kufooketsa zochita za insulin glargine:

• ma anti-kutupa mahomoni omwe amachepetsa chitetezo cha mthupi,
• Danazol - mankhwala omwe ali m'gulu la mankhwala ena a androgens,
• Diazoxide
• mankhwala okodzetsa
• mankhwala okhala ndi analogi ya estrogen ndi progesterone,
• kukonzekera komwe kwapangidwa pamaziko a phenothiazine,
• mankhwala omwe amalimbitsa kapangidwe ka norepinephrine,
• mawonekedwe a mahomoni a chithokomiro.
• Kukonzekera kokhala ndi mawonekedwe achilengedwe kapena ofunikira a mahomoni okula,
• antipsychotropic mankhwala
• proteinase zoletsa.

Palinso mankhwala ena omwe zotsatira zake sizikudziwika. Amatha kufooketsa mphamvu ya insulin glargine ndikuyipangitsa. Mankhwalawa ndi monga:

• B-blockers
• kuthamanga kwa magazi komwe kumachepetsa mankhwala
• mchere wa lithiamu
• mowa

Kuti mupeze analogue yotsika mtengo kwa mankhwala, a generic kapena ofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezi zomwe zikugwiritsidwa ntchito ndikuwonetsa. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina.

Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Tisanthula momwe tingagwiritsire ntchito Lantus - malangizo oti agwiritse ntchito akuti ayenera kulowetsedwa mosavomerezeka m'matumbo a mafuta pakhoma lakumbuyo, ndipo sangathe kugwiritsidwa ntchito kudzera m'mitsempha. Njira iyi yogwiritsira ntchito mankhwalawa idzatsogolera kutsika kwakukulu kwamagazi a glucose ndikukula kwa chikumbumtima cha hypoglycemic.

Kuphatikiza pa CHIKWANGWANI pamimba, pali malo ena oyambitsira a Lantus - minofu yachikazi, yachikazi. Kusintha kwake muzochitika izi ndizosafunikira kapena kulibe.

Homoni sangaphatikizidwe pamodzi ndi mankhwala ena a insulin, sangathe kuchepetsedwa musanagwiritse ntchito, chifukwa izi zimachepetsa mphamvu yake. Ngati mumasakanikirana ndi zinthu zina zamankhwala am'madzi, mpweya ndiwotheka.

Kuti muchite bwino pochiritsa, Lantus iyenera kugwiritsidwa ntchito mosalekeza, tsiku lililonse pafupifupi nthawi yomweyo.

Ndi mtundu wanji wa insulini yomwe muyenera kugwiritsira ntchito matenda ashuga, endocrinologist angakulangizeni. Nthawi zina, mankhwalawa amagwiritsidwa ntchito mwachisawawa; nthawi zina pamafunika kuphatikiza ma insulin omwe amakhala nthawi yayitali komanso amakhala nthawi yayitali. Chitsanzo cha kuphatikiza kotere ndi kugwiritsidwa ntchito palimodzi kwa Lantus ndi Apidra, kapena kuphatikiza monga Lantus ndi Novorapid.

Muzochitika izi, pazifukwa zina, zimayenera kusintha mankhwalawa Lantus Solostar kupita kwina (mwachitsanzo, kupita ku Tujeo), malamulo ena ayenera kuwonedwa. Chofunika kwambiri, kusinthaku sikuyenera kumayenderana ndi kupsinjika kwakukulu kwa thupi, kotero simungathe kutsitsa mlingo wa mankhwalawa kutengera kuchuluka kwa magawo omwe mungagwiritse ntchito.

M'malo mwake, m'masiku oyamba kukonzekera, kuwonjezeka kwa insulini komwe kumathandizira kuti mupewe hyperglycemia. Makina onse amthupi atayamba kugwiritsa ntchito bwino mankhwala, mutha kuchepetsa mankhwalawo kuti akhale olondola.

Zosintha zonse munthawi ya mankhwala, makamaka zomwe zimakhudzana ndi mankhwala ndi ma analogues, ziyenera kuvomerezedwa ndi dokotala, yemwe amadziwa momwe mankhwala amasiyana ndi omwe amathandizanso.

Zizindikiro zogwiritsidwa ntchito

Lantus adawonekera koyamba mu 2003 ndipo kuyambira pamenepo amadziwika kuti ndi amodzi a othandizira kwambiri a insulin ndipo nthawi yomweyo, zina mwazabwino kwambiri ndizabwino.

Chomwe chimagwira ndi insulin glargine.

Paketi yovomerezeka ya mankhwalawa imaphatikizapo mabotolo okhala ndi yankho la 10 ml (100 PIECES). Ngati mankhwalawa aperekedwa m'makalata, ndiye kuti phukusi limodzi lokhala ndi makatoni 5 a 3 ml iliyonse.

Malangizo ogwiritsira ntchito

Lantus ndi insulin yomwe imakhala nthawi yayitali, yomwe ikuwonetsedwa ngati imagwiritsidwa ntchito mu matenda a shuga 1 komanso mtundu 2 wa shuga, mukamakana kukonzekera kwina kwa insulin.

Insulin yamtunduwu imapangidwa ndi ma genetic engineering ndipo, chifukwa chake, molekyulu ya mahomoni imapeza zinthu zomwe zimamasulidwa pang'onopang'ono, zomwe zimatsimikizira kuti katundu wa mankhwalawo kuti asakhale ndi machitidwe ochitikachitika, amapereka moyenera komanso pang'onopang'ono insulini ndikupanga nthawi yayitali kuposa mitundu yonse ya insulin.

Mankhwalawa amakhala ndi nthawi yayitali chifukwa choti acidity yothetsera vutoli ili ndi zotsika ndipo izi zimapangitsa kuchepa kwa mahomoni m'zinthu zowonongeka. Monga lamulo, Lantus imagwira tsiku limodzi, ndipo nthawi zina mpaka maola 29.

Ndikofunikira kudziwa: Lantus sayenera kuchepetsedwa ndi madzi osungunuka, mchere.

Mankhwala amakhala ndi zotsatira zokhazikika.

Mlingo woyambirira wa mankhwalawa amawerengedwa payekhapayekha. Mankhwalawa amathandizidwa nthawi zonse kamodzi patsiku, makamaka nthawi imodzi, phewa, m'mimba kapena ntchafu yamkati, ndipo malo a jekeseni amayenera kusintha nthawi zonse.

Apa muwerenga za zovuta zonse zamatenda a insulin a mtundu 1 ndi mtundu wa 2 matenda a shuga. Kodi mitundu ya insulini potengera nthawi yayitali ikuchitanji? Yankho lili munkhani yathu.

Ngati Lantus adalandira wodwala matenda a shuga 1, ndiye kuti mankhwalawo amagwiritsidwa ntchito ngati mankhwala oyenera.

Mtundu wachiwiri wa matenda ashuga, wodwala amatha kupatsidwa mankhwala othandizira kapena othandizira ena.

Wodwala yemwe ali ndi matenda ashuga atha kusamutsidwa kupita ku mtundu wina wa insulin kupita ku Lantus, ndikofunikira kuyendetsa mosamala kuchuluka kwa shuga kwa masiku angapo kuti asinthe ndikuzindikira mtundu wa mankhwala omwe akufuna.

Zotsatira zosagwiritsidwa ntchito ndi mankhwalawa:

• Kusalolera payekha pakumwa mankhwala,
• Zaka za ana (zosavomerezeka kwa ana osakwana zaka 6),
• Hypoglycemia,
• Mimba komanso nthawi yotsatira ya mkaka wa m`mawere.

Monga lamulo, ma insulin onse omwe amafanana ndi mahomoni amunthu amayambitsa zovuta zoyambirira kumayambiriro kwa zamankhwala ndipo izi zimachitika chifukwa chakuti wodwala matenda ashuga sangawerenge molondola kuchuluka kwa mankhwalawo omwe amafunikira ndikuvulala kwambiri kuposa momwe akufunira kapena mochepera. Pakupita masiku ochepa, pamene munthu ayang'anitsitsa mosamala, kusintha kwa insulin, mawonekedwe onse osafunikira amachoka:

• Zofooka
• Kusanza ndi kusanza
• Mutu
• Woopsa milandu, pamene mlingo udali waukulu - kutaya chikumbumtima, hypoglycemia.

Ndikofunikira kudziwa: zovuta zina zomwe zimachitika mwa wodwala yemwe ali ndi matenda osokoneza bongo amatha "kuyankha" ku chithandizo cha Lantus. Chifukwa chake, musanapereke mankhwala, dokotala ayenera kuchita mayeso onse kuti adziwe zovuta.

Muyeneranso kusamala ndi mankhwalawa kwa odwala omwe ali kale ndi matenda a impso, chifukwa Masiku ano, momwe mankhwalawa amathandizira pogwira ntchito ziwalo zamkati sizidziwika.

Nthawi zina wodwala yemwe ali ndi matenda a shuga amatha Lantus kuti azindikire kuti mwanjira yake ya insulin mwadzidzidzi amayamba kupereka zotsatira zoyipa ndipo amayeneranso kusintha mankhwalawo. Izi zitha kuphatikizaponso:

• Kusintha kwa tsamba la jakisoni
• Mulingo waukulu wa insulin,
• Kuchita zolimbitsa thupi kwambiri (kungakhale motalika kwambiri ndikuwonjezereka),
• Matenda ena
• Zakudya zosokoneza ndikudya zakudya zosaloledwa,
• Milandu yotumiza mphamvu,
• Kumwa mowa
• Matenda a Endocrine
• Zotsatira zoyipa za mankhwala omwe amagwiritsidwa ntchito pochiza matenda ena (omwe si a shuga).

Mankhwala akuwonetsedwa kuti agwiritse ntchito zotsatirazi:

• ngati munthu wapezeka ndi matenda a shuga 1 a mtundu wa mellitus (wodalira insulin),
• ngati munthu wapezeka ndi matenda a shuga 2 a mellitus (osadalira insulini),

Tiyenera kudziwa kuti mankhwalawa amachokera mtundu wachiwiri wa matenda a shuga, mankhwalawa amayamwa pakamwa. Komabe, nthawi zina, odwala amakumana ndi zovuta zawo. Ndipo pomwepo dokotalayo amalembera makonzedwe a insulin modzidzimutsa.

Insulin Lantus itha kutumizidwa kwa odwala omwe ali ndi matenda osokoneza bongo omwe amadalira matenda a shuga ngati matenda ena omwe amafunikira chithandizo cham'mbuyomu alowa nawo matendawa.

Musanagwiritse ntchito insulin Lantus, malangizo ogwiritsira ntchito ayenera kuphunziridwa mosamala. Tiyenera kukumbukira kuti mankhwalawa amaletsedwa kulowetsedwa m'mitsempha, chifukwa amatha kupangitsa kukula kwa mitundu yayikulu ya hypoglycemia.

Mutha kubayira mbali zotsatirazi zathupi:

• pakhoma pamimba,
• kulowa mumsempha wokhathamira
• kulowa ntchafu.

Pochita maphunziro, panalibe kusiyana pakati pa kuphatikizira kwa insulin m'malo osiyanasiyana a thupi.

Mankhwala Insulin Lantus SoloStar amapezeka mu mawonekedwe a cholembera, omwe amakhala ndi makatoni omangira okhala ndi yankho la insulin. Imatha kugwiritsidwa ntchito. Potere, yankho litatha, chogwirira chimayenera kutayidwa.

Mankhwala Insulin Lantus OptiKlik ndi cholembera cha syringe chomwe chimagwiritsidwa ntchito mobwerezabwereza pambuyo pokhazikitsa katoni yakale ndi watsopano.

Tujeo ndi Lantus amakonzekera insulin mwa mawonekedwe amadzimadzi a jakisoni.

Mankhwalawa amagwiritsidwa ntchito ngati mtundu wa 1 komanso matenda a shuga a 2, pomwe matenda a shuga sangatheke popanda kugwiritsa ntchito jakisoni wa insulin.

Ngati mapiritsi a insulin, zakudya zapadera, komanso kutsatira mosamalitsa njira zonse zomwe zimaperekedwa sizithandiza kuti shuga ya magazi ikhale pansi pazovomerezeka, kugwiritsa ntchito Lantus ndi Tujeo. Monga kafukufuku wazachipatala wawonetsa, mankhwalawa ndi njira yothandiza yowunikira kuchuluka kwa shuga m'magazi.

M'maphunziro omwe opangidwa ndi mankhwalawa amapanga, kampani yaku Germany ya Sanofi, maphunziro adakhudza odzipereka okwana 3,500.Onsewa anali ndi matenda osokoneza bongo a mitundu yonse iwiri.

M'miyezi isanu ndi umodzi yofufuza zamankhwala, magawo anayi a kuyesera adachitika.

Mu gawo loyamba ndi lachitatu, chidwi cha Tujeo paumoyo wa odwala matenda ashuga a 2 adaphunzira.

Gawo lachinayi lidadzipereka pantchito ya Tujeo pa odwala omwe ali ndi matenda ashuga a mtundu woyamba. Malinga ndi zotsatira za kafukufuku, luso la ku Tujeo lidawululidwa.

Contraindication

1. Ndi zoletsedwa kugwiritsa ntchito mwa odwala omwe ali ndi vuto la insulin glargine kapena othandizira.
2. Hypoglycemia.
3. Chithandizo cha matenda ashuga ketoacidosis.
4. Ana osakwana zaka 2.

Zotheka zimachitika kawirikawiri, malangizowo akuti mwina atha:

• lipoatrophy kapena lipohypertrophy,
• matupi awo sagwirizana (edema ya Quincke, mantha onse, bronchospasm),
• kupweteka kwa minyewa ndi kuchedwa mu thupi la ayodini,
• dysgeusia ndi kuwonongeka kwa mawonekedwe.

Kusintha kupita ku Lantus kuchokera ku insulin ina

Ngati munthu wodwala matenda ashuga agwiritsa ntchito ma insulin apakatikati, ndiye kuti musinthana ndi Lantus, muyezo ndi mtundu wa mankhwalawo umasinthidwa. Kusintha kwa insulin kuyenera kuchitika kokha kuchipatala.

M'tsogolomu, dokotala amayang'ana shuga, njira yodwalayo, kulemera kwake ndikusintha kuchuluka kwa mayendedwe omwe amaperekedwa. Pakatha miyezi itatu, kugwiritsa ntchito bwino kwa mankhwalawa kungayang'anitsidwe ndikusanthula kwa hemoglobin ya glycated.

Malangizo pavidiyo:

Ku Russia, onse odwala matenda a shuga omwe amadalira insulin adasamutsidwa kuchoka ku Lantus kupita ku Tujeo. Malinga ndi kafukufuku, mankhwalawa ali ndi chiopsezo chochepa cha kukhala ndi hypoglycemia, koma machitidwe, anthu ambiri amadandaula kuti atasinthira ku Tujeo shuga wawo adalumphira kwambiri, motero amakakamizidwa kugula okha Lantus Solostar insulin.

Levemir ndi mankhwala abwino kwambiri, koma ali ndi chinthu china chogwira ntchito, ngakhale nthawi yayitali ndi maola 24.

Aylar sanakumane ndi insulin, malangizo akuti uyu ndi Lantus yemweyo, koma wopanga ndi wotsika mtengo.

Insulin Lantus pa nthawi yapakati

Maphunziro a zachipatala a Lantus omwe ali ndi amayi apakati sanachitike. Malinga ndi zomwe sizinalembedwera, mankhwalawa samakhudza kwambiri mayendedwe a mwana komanso iyemwini.

Kuyesera kunachitika pa zinyama, pomwepo zimatsimikiziridwa kuti insulin glargine ilibe vuto la kubereka.

Lantus Solostar woyembekezera atha kutumikiridwa pokhapokha insulin NPH isagwire ntchito. Amayi amtsogolo akuyenera kuwunika shuga wawo, chifukwa mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, komanso mu trimester yachiwiri ndi yachitatu.

Osawopa kuyamwitsa mwana; malangizo ake alibe zomwe Lantus imatha kudutsa mkaka wa m'mawere.

Momwe mungasungire

Alumali moyo wa Lantus ndi zaka 3. Muyenera kusungira m'malo amdima otetezedwa ndi kuwala kwa dzuwa pa kutentha kwa madigiri 2 mpaka 8. Nthawi zambiri malo abwino kwambiri ndi firiji. Poterepa, onetsetsani kuti mwayang'ana kutentha, chifukwa kuzizira kwa insulin Lantus koletsedwa!

Kuyambira koyamba kugwiritsa ntchito, mankhwalawa amatha kusungidwa kwa mwezi umodzi m'malo opanda pake kutentha osaposa 25 digiri (osati mufiriji). Osagwiritsa ntchito insulin yomwe yatha.

Poti mugule, mtengo

Lantus Solostar amalembedwa mwaulere ndi mankhwala ndi endocrinologist. Komanso zimachitika kuti wodwala matenda ashuga ayenera kugula yekha mankhwala ku pharmacy. Mtengo wamba wa insulin ndi ma ruble 3300. Ku Ukraine, Lantus angagulidwe 1200 UAH.

Odwala matenda ashuga akuti ndi insulin yabwino kwambiri, kuti shuga yawo imasungidwa mwa malire. Nazi zomwe anthu akunena za Lantus:

Ambiri adangotsala ndemanga zabwino zokha.Anthu angapo adanena kuti Levemir kapena Tresiba ndiwofunikira.

Zotsatira zoyipa

Ngati muli ndi zizindikiro zofanana ndi zomwe tafotokozazi, lemberani dokotala wanu nthawi yomweyo!

Hypoglycemia, zotheka kwambiri chifukwa cha mankhwala a insulin, zimatha kuchitika ngati mlingo wa insulin ndiwokwera kwambiri poyerekeza ndi kufunika kwake.

Zotsatirazi zotsatirazi zomwe zimagwiritsidwa ntchito ndi mankhwala omwe amawoneka panthawi yazachipatala amayesedwa pansipa kwa magawo a ziwalo zamagetsi pang'onopang'ono pazomwe zimachitika (zambiri:> 1/10, nthawi zambiri> 1/100 mpaka 1/1000 mpaka 1/10000 kupita

Zolemba ntchito

Lantus ali osavomerezeka zochizira matenda ashuga ketoacidosis. Zikatero, njira yolimbikira ya insulin yochepa imalimbikitsidwa.

Pankhani yopewa kugwiritsa ntchito shuga pamagazi, komanso ngati pali vuto lokhala ndi hypo- kapena hyperglycemia, musanapitirize kukonza mankhwalawa, ndikofunikira kuyang'ana kulondola kwa mankhwala, njira zoyendetsera mankhwala ndi njira yovomerezeka yovundira, zinthu zonse zokhudzana ndi vutoli. Chifukwa chake, kudziyang'anira mosamala ndikusunga dijenda kumalimbikitsidwa kwambiri.

Kusinthana ndi mtundu wina kapena mtundu wa insulin uyenera kuchitika moyang'aniridwa ndi achipatala. Kusintha kwa muyezo, wopanga, mtundu (NPH, wogwira ntchito mwachidule, wokhala ndi nthawi yayitali, ndi zina), chiyambi (chinyama, munthu, analogi ya insulin ya anthu) ndi / kapena njira yopangira zitha kuchititsa kusintha kwa mlingo.

Nthawi ya kukonzekera kwa hypoglycemia zimatengera mawonekedwe a omwe amagwiritsidwa ntchito chifukwa cha insulin, motero, angasinthe ndikusintha kwa regimen yothandizira. Chifukwa cha kuchuluka kwa nthawi yomwe zimatenga kuti munthu akhale ndi insulin yayitali kulowa mthupi pogwiritsa ntchito Lantus, munthu akuyenera kuyembekezera kucheperachepera kugona kwa hypoglycemia, pomwe izi zitha kuchuluka m'mawa kwambiri.

Odwala omwe ma episode a hypoglycemia amatha kukhala ndi vuto la kuchipatala, monga odwala omwe ali ndi vuto lalikulu la mitsempha ya mitsempha kapena mitsempha ya m'magazi (chiopsezo cha matenda a mtima ndi matenda a hypoglycemia), komanso odwala omwe akukhala ndi prinogathy wambiri. kuchepa kwamono kwakanthawi chifukwa cha hypoglycemia), kusamala kwapadera kuyenera kuonedwa, ndikuwonetsetsa kwambiri za shuga wamagazi ndikulimbikitsidwa.

Kumbukirani kuti nthawi zina mutha kusintha momwe zizindikiritso za hypoglycemia zimakhalira,

- odwala omwe asintha kwambiri magazi a shuga,

- odwala omwe hypoglycemia imayamba pang'onopang'ono,

- odwala okalamba,

- Odwala atatha kusintha ma insulin kuchokera ku nyama kupita ku insulin yaumunthu,

- odwala neuropathy,

- odwala omwe ali ndi shuga yayitali,

- odwala omwe ali ndi mavuto amisala,

odwala omwe amalandila chithandizo chamankhwala ena (onani kuyanjana ndi mankhwala ena).

Yaitali mphamvu ya subcutaneous makonzedwe a insulin glargine amatha kuchepa msanga pambuyo hypoglycemia.

Ngati kuchuluka kwa kuchepa kwa khungu kapena kuchepa kwa khungu kwa khungu kwa glycosylated hemoglobin kumadziwika, ndikofunikira kulingalira za mwayi wokhala ndi zigawo za hypoglycemia zomwe zimachitika mobwerezabwereza (makamaka usiku).

Kutsatira kwa odwala ndi dongosolo la dosing, zakudya ndi zakudya, kugwiritsa ntchito bwino insulini komanso kuwongolera kuyambika kwa zizindikiro za hypoglycemia kumathandizira kuchepetsa kwambiri chiopsezo cha hypoglycemia.Zinthu zomwe zimawonjezera kukonzekera kwa hypoglycemia zimafunikira kuwunikira mosamala, monga angafunikire kusintha kwa insulin. Izi ndi monga:

- kusintha kwa oyang'anira a insulin,

- kuchuluka kwa chidwi ndi insulin (mwachitsanzo, mukamachotsa kupsinjika),

- zachilendo, kuchuluka kapena zolimbitsa thupi nthawi yayitali,

- Matenda oyenda limodzi ndi kusanza, kutsekula m'mimba,

- kuphwanya zakudya ndi zakudya,

- kudumphika chakudya

- mavuto ena a endocrine osawerengeka (mwachitsanzo, hypothyroidism, kusakwanira kwa adenohypophysis kapena adrenal cortex),

- kugwiritsa ntchito limodzi ndi mankhwala ena (onani kuyanjana ndi mankhwala ena).

Matenda ophatikizika, kuyang'anira kwambiri shuga pamafunika. Mwambiri, kusanthula kumachitika kuti pakhale matupi a ketone mumkodzo, ndipo insulin dosing imafunikira nthawi zambiri. Kufunika kwa insulin nthawi zambiri kumachuluka. Odwala omwe ali ndi matenda amtundu wa 1 ayenera kupitiliratu kudya chakudya chochepa, ngakhale atatha kudya zakudya zochepa kapena sangathe kudya ngakhale atasanza, etc. Odwala awa sayenera kusiya kuperekera insulin.

Zolakwa zamankhwala zidanenedwa pomwe ma insulin ena, makamaka osakhalitsa, omwe adaperekedwa mwangozi m'malo mwa glargine insulin. Zolemba za insulini ziyenera kuyang'aniridwa nthawi iliyonse jakisoni iliyonse isanachitike kuti mupewe cholakwika chamankhwala pakati pa insulin glargine ndi insulin zina.

Kuphatikiza kwa Lantus ndi pioglitazone

Milandu yakulephera kwa mtima idanenedwa pomwe pioglitazone imagwiritsidwa ntchito limodzi ndi insulin, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima. Izi zikuyenera kukumbukiridwa popereka kaphatikizidwe ka pioglitazone ndi Lantus. Mukamwa mankhwala osakanikirana, ndikofunikira kuyang'anira odwala molingana ndi mawonekedwe a zizindikiro ndi zizindikiro za kulephera kwa mtima, kuchuluka kwa thupi ndi edema.

Pioglitazone iyenera kusiyidwa ngati vuto lina lililonse la kufooka kwa mtima likupezeka.

Kukopa pa luso loyendetsa galimoto ndikugwira ntchito ndi magwiridwe antchito

Mphamvu ya wodwalayo yokhazikika komanso kuyankha mwachangu pazinthu zakunja imatha kusokonezeka chifukwa cha kukula kwa hypoglycemia kapena hyperglycemia, kapena, mwachitsanzo, chifukwa cha kuwonongeka kwa mawonekedwe. Izi zitha kukhala zowopsa pazochitika zina pomwe kuthekera uku ndikofunika kwambiri (mwachitsanzo, poyendetsa galimoto kapena pogwira ntchito ndi njinga zovuta).

Wodwala ayenera kudziwitsidwa mosamala kuti apewe kukula kwa hypoglycemia poyendetsa. Izi ndizofunikira kwambiri kwa odwala omwe achepetsa kapena kusazindikira zizindikiro zowopsa za hypoglycemia, komanso kwa odwala omwe nthawi zambiri amakumana ndi zochitika za hypoglycemia. Kuganizira moyenera kuyenera kuthandizidwa kuti athe kuyendetsa galimoto kapena kugwiritsa ntchito njira zovuta ngati izi.

Kutulutsa Fomu

10 ml mu botolo lagalasi lowonekera, lopanda utoto (mtundu I). Botolo limasindikizidwa ndi cholembera cha chlorobutyl, chofowoleredwa ndi chipewa cha aluminium ndikutchinga ndi kapu yoteteza yopangidwa ndi polypropylene. Botolo imodzi imayikidwa limodzi ndi malangizo ogwiritsira ntchito pabokosi lamakatoni.

3 ml pa katoni imodzi yagalasi looneka bwino. Katirijiyo amasindikizidwa kumbali imodzi ndi choletsa cha brkidutyl ndikuwombedwa ndi chipewa cha aluminium, inayo ndi brwaputyl plunger. Makatoni asanu pazinthu zilizonse za filimu ya PVC ndi zojambulazo.Mzere umodzi wa blister umayikidwa limodzi ndi malangizo ogwiritsira ntchito pabokosi lamatoni.

3 ml iliyonse pakabati katiriji komveka bwino (mtundu I). Katirijiyo amasindikizidwa kumbali imodzi ndi choletsa cha brkidutyl ndikuwombedwa ndi chipewa cha aluminium, inayo ndi brwaputyl plunger. Katoniyo amaikiramo cholembera

Malo osungira

Sungani pa kutentha kwa + 2 ° C mpaka + 8 ° C pamalo amdima.

Pewani kufikira ana.

Osamawuma! Musalole kuti chidebe chilumikizane mwachindunji ndi mafayilo kapena zinthu zachisanu.

Mukatha kugwiritsa ntchito, sungani kutentha osapitirira 25 25 C mu katoni (koma osati mufiriji).

Tsiku lotha ntchito

Njira yothira mankhwala m'mabotolo ndi zaka ziwiri.

Njira yothetsera mankhwalawa mu cartridgeges ndi cholembera cha SoloStar® ndi zaka zitatu.

Tsiku lotha litatha, mankhwalawo sangathe kugwiritsidwa ntchito.

Chidziwitso: moyo wa alumali mankhwalawa kuyambira nthawi yoyamba kugwiritsa ntchito masabata anayi. Ndikulimbikitsidwa kuyika tsiku lomwe kuchotsedwa kwa mankhwalawo kulembetsa.