Momwe mungatenge Victoza mu matenda a shuga a 2

Zambiri zokwanira pa kugwiritsa ntchito mankhwalawa Victoza® mwa amayi apakati sizikupezeka. Kafukufuku wazinyama awonetsa kuwopsa kwa mankhwalawa (onani Pharmacokinetics, Preclinical Security Study Data). Chiwopsezo chotheka kwa anthu sichikudziwika.

Amadzipaka kugwiritsa ntchito mankhwala a Viktoza® pa nthawi yoyembekezera, m'malo mwake, amalimbikitsidwa kuchita ndi insulin. Ngati wodwala akukonzekera kukhala ndi pakati kapena kuti wayamba kale, chithandizo chokhala ndi Victoza® chiyenera kuyimitsidwa nthawi yomweyo.

Mukanyamula mwana, Victoza amaletsedwa kuthandizidwa. Palibe zambiri pakugwiritsa ntchito mankhwalawa ndi amayi oyembekezera. Panthawi ya maphunziro a nyama, kupezeka kwa kawopsedwe ka kubereka kwa liraglutide kudakhazikitsidwa. Chiwopsezo chotheka cha amayi ndi ana sichikudziwika, pofuna kupewa zovuta, ndizoletsedwa kugwiritsa ntchito chida chowonetsedwa.

Ndikofunikira kukana chithandizo chamankhwala ndi Viktoza kale panthawi yakukonzekera. Ngati zidadza mosayembekezereka, ndiye kuti amasiya jakisoni nthawi yomweyo, monga momwe zidadziwikira pobadwa kwa moyo watsopano. Ngati ndi kotheka, pitilizani mankhwala ndi insulin.

Viktoza pa nthawi yoyembekezera / mkaka wa m`mawere sichimawerengedwa.

Zokwanira pa kugwiritsa ntchito mankhwalawa kwa amayi apakati sizipezeka. Pa kafukufukuyu, kawirikawiri kubala kwa liraglutide kudakhazikitsidwa. Chiwopsezo chomwe chilipo kwa anthu sichinakhazikitsidwe. Pokonzekera wodwala pakati kapena pakakhala pakati, Victoza amasiya.

Mbiri ya chitetezo cha Victoza panthawi yachulukirapo sichinaphunzire.

Zambiri zokwanira pa kugwiritsa ntchito mankhwalawa Victoza® mwa amayi apakati sizikupezeka. Kafukufuku wazinyama awonetsa kuwopsa kwa mankhwalawa. Chiwopsezo chotheka kwa anthu sichikudziwika.

Mankhwala Viktoza ® sangathe kutumikiridwa panthawi yomwe ali ndi pakati, m'malo mwake, amalimbikitsidwa kuti azichita mankhwalawa ndi insulin. Ngati wodwalayo akukonzekera kutenga pakati, kapena kuti mimba yayamba kale, chithandizo chokhala ndi Victoza® chiyenera kuyimitsidwa nthawi yomweyo.

Mtengo wa mankhwala

Mpaka pano, pamsika wa pharmacological mulibe chithunzi chonse cha mankhwala a Viktoza.

Mtengo wa mankhwalawa, choyambirira, zimatengera kuchuluka kwa zolembera m'matumba.

Mutha kugula mankhwala mumasitolo amzinda kuchokera ku ruble 7 mpaka 11,2.

Mankhwala otsatirawa ndi ofanana mu zotsatira zawo zamankhwala, koma ndi mankhwala ena:

1. Novonorm ndi piritsi lomwe limakhala ndi kuchepetsa shuga m'thupi. Wopanga mankhwalawa ndi Germany. Chofunikira chachikulu pa chinthu ndi mankhwala. Nthawi zambiri amagwiritsidwa ntchito posagwiritsa ntchito mankhwala osokoneza bongo omwe amadalira shuga, monga chida chachikulu kapena kuphatikiza mankhwala ndi metformin kapena thiazolidinedione. Mtengo wa mankhwalawa, kutengera mlingo, umasiyana kuchokera ku ma 170 mpaka ma ruble 230.
2. Baeta ndi mankhwala osokoneza bongo omwe amadziwika kuti ndi othandizira polimbana ndi zovuta za matenda a shuga. Amapezeka mu mawonekedwe a yankho la subcutaneous jakisoni. Chofunikira chachikulu ndi exenatide. Mtengo wamba wa mankhwalawa m'masitolo ndi ma ruble 4,000.

Kuphatikiza apo, analogi ya mankhwala Viktoza ndi Luxumia

Dokotala wokhayo ndi amene angaganize zofunikira pakuthandizira mankhwalawa panthawi ya achire.

Kanemayo munkhaniyi amafotokoza za mankhwala omwe amachepetsa shuga ya magazi.

Kafukufuku wambiri akuwonetsa pang'ono pharmacokinetic zochita ndi mankhwala komanso kutsika kwa mapuloteni am'madzi a plasma:

1. Paracetamol Mlingo umodzi samabweretsa kusintha kwakukulu mthupi.
2. Griseofulvin. Sichimayambitsa zovuta komanso kusintha kwa thupi, pokhapokha ngati mlingo umodzi umaperekedwa.
3. Lisinopril, Digoxin. Zotsatira zake zimachepetsedwa ndi 85 ndi 86%, motsatana.
4. Njira zakulera. Mankhwala alibe matenda.
5. Warfarin. Palibe maphunziro. Chifukwa chake, tikamagwiritsidwa ntchito palimodzi, tikulimbikitsidwa kuwunika momwe thanzi lamunthu liliri.
6. Insulin Palibe maphunziro azachipatala; mukamagwiritsa ntchito Victoza, kuyang'anira momwe thupi limathandizira.

Mofananamo wathunthu pamsika wa pharmacology kulibe.

Mndandanda wamankhwala omwe ali ndi vuto lofanana ndi thupi:

1. Novonorm. Mankhwala ochepetsa shuga. Wopanga - Germany. Chofunikira chachikulu ndi Repaglinide. Zimapezeka kwa aliyense chifukwa cha mtengo wa bajeti ya ma ruble 170 mpaka 230.
2. Byeta. Mankhwalawa ndi a odwala omwe amadalira insulin. Imapezeka ngati yankho la jakisoni wa sc. Gawo lothandizira - Exenadit. Mtengo wapakati ndi ma ruble 4000.
3. Luxumia. Kugwiritsidwa ntchito ndi lingaliro la dokotala. Ili ndi ntchito yothandiza, malinga ndi kutsatira kwambiri malangizo.

Victoza sangathe kutchedwa wotchipa kwa odwala osiyanasiyana. Mankhwalawa, omwe cholembera cha 3 ml chogwiritsiridwa, angagulidwe kwa ma ruble 10,000. Victoza sakupezeka kuti angagulitsidwe, amangogulidwa kokha ndi mankhwala.

Mankhwala Viktoza ndiofunika kwa anthu omwe ali ndi matenda a shuga a 2, koma ngati adalangizidwa kwa odwala kuti awone zina, ndiye kuti ayenera kugwiritsa ntchito mosamala monga momwe adalembera.

Madokotala onse, kupatula, amawona kuti mankhwalawa ndi akulu ndikulimbikitsa kuti mugwiritse ntchito mosamalitsa monga momwe akuwonera, komwe ndi pamaso pa mtundu II matenda a shuga. Pokhapokha ngati izi, chithandizo ndi wothandizirayi ndi chomwe chidzapatse zotsatira zabwino, chifukwa kunenepa kwambiri kumapangitsa gawo lalikulu pano.

Mankhwala omwe amagwiritsidwa ntchito pazolinga zake amaletsa kukula kwa matenda ashuga komanso zovuta zake. Mothandizidwa bwino shuga ndi kubwezeretsa zachilengedwe kupanga insulin.

Victoza amayambitsa chidwi ndi njala. Odwala ena adatha kutsika mpaka 8 kg pa mwezi.

Madokotala amachenjeza kuti mankhwalawa sayenera kuperekedwa nokha ndipo muchepetse thupi basi. Zimatha kuyambitsa khansa ya chithokomiro komanso zimayambitsa mawonekedwe a pancreatitis pachimake. Kugwiritsa ntchito mosagwiritsa ntchito Victoza.

Ndemanga za iwo omwe achepetsa thupi ndi zosiyana kwambiri. Oipa amati kuchepa thupi pang'ono, makilogalamu 1-3 pamwezi.

Kuwonongeka kwa thanzi, kusokonezeka kwa metabolic, kupweteka pamutu ndi kudzimbidwa kumadziwika. Sakuwona kufunika kokagulanso, chifukwa mukufunikirabe kutsatira kadyedwe ndikuyang'anira kulimba.

Monga lamulo, anthuwa adagwiritsa ntchito mankhwalawa popanda mankhwala a dokotala komanso popanda umboni wapadera.

Zotsatira zabwino za mankhwala "Viktoza" a odwala omwe ali ndi matenda amtundu II. Anthu awa amawonetsa kuchepa kwakukulu, makilogalamu 8-15 pamwezi.

Zinali zotheka kukwaniritsa izi osati kokha ndi mphamvu ya mankhwalawo pathupi, komanso ndi chakudya choyenera komanso zolimbitsa thupi. Odwala amawonetsa kupepuka mthupi lonse, kusintha kwa mtima wamagazi, kuchepa kwa chakudya ndi kuchepa kwa ma kilogalamu osafunikira.

Anthuwa adakhutira ndikuyenda bwino kwa yankho la Victoza.

Mankhwala "Victoza" amatanthauza mankhwala okwera mtengo (ndemanga za madokotala amazindikira kufunika koyezetsa thupi lonse musanagwiritse ntchito chida ichi). Mtengo wake mu cholembera cha 3 ml syringe No. 2 umasiyana m'chigawo cha rubles 3,000. Mankhwalawa amagulitsidwa m'mafakisoni wamba ndipo amaperekedwa kokha mwa mankhwala.

Njira yothetsera Victoza ndiyofunikira kwa anthu odwala matenda ashuga a II, koma anthu ena onse azigwiritsa ntchito mosamalitsa monga momwe zalembedwera.

Wovutitsidwayo amatha kuthandizira kuchepetsedwa pang'ono m'mimba, zomwe zimapangitsa kusintha kwa mankhwalawa am'kamwa. Malinga ndi kafukufuku, izi sizikhala ndi phindu lililonse m'thupi, motero kusintha kwa mankhwalawa sikofunikira.

Zovuta zapadera za matenda am'mimba pazakumwa ndi liraglutide amadziwika (zingakhudze mayamwidwe amodzi omwe amagwiritsidwa ntchito pakamwa panthawi yomweyo).

Pogwiritsa ntchito warfarin kapena zotumphukira zina za coumarin, ndikofunikira kuyang'anira INR pafupipafupi (International Normalized Ratio).

Zinthu zomwe zimawonjezeredwa ku Viktoza zimatha kubweretsa kuchepa kwa liraglutide, chifukwa chake siziyenera kusakanikirana ndi mankhwala ena, kuphatikizapo njira zobayira.

Kuwunika kwa vitro kwa liraglutide kunawonetsa kuchepa kwake kochepetsetsa kwa pharmacokinetic ndi mankhwala omwe amapangidwa ndi ma enzymme system ya cytochrome P450, komanso kumangiriza mapuloteni a plasma.

Kuchepetsa pang'ono m'matumbo chifukwa cha liraglutide kungayambitse mayamwidwe amkamwa oyanjana. Kafukufuku wokhudzana ndi zamankhwala pakukhudzana ndi mankhwalawa ndi mankhwala ena sikuwonetsa chiwopsezo chachikulu cha kuperewera kwa mankhwalawa.

Odwala angapo omwe amathandizidwa ndi Victoza® anali ndi gawo limodzi la matenda otsekula m'mimba. Kutsekula m'mimba kumatha kuthana ndi mayamwa am'magazi omwe amagwiritsidwa ntchito nthawi imodzi ndi Victoza®.

Liraglutide sizinapangitse kusintha kwawonekera kwa paracetamol atatha kumwa muyezo umodzi wa 1000 mg. Ma plasma max paracetamol adatsika ndi 31%, ndipo Tmax yapakati idakulitsidwa ndi mphindi 15. Ndi munthawi yomweyo makonzedwe a liraglutide ndi paracetamol, kusintha kwa mankhwalawa sikofunikira.

Liraglutide sizinachititse kusintha kwakukulu kwapangidwe ka atorvastatin pambuyo poti wapereka gawo limodzi la 40 mg. Chifukwa chake, kusintha kwa mlingo wa atorvastatin pamene mukumwa Victoza® sikofunikira. Cmax ya atorvastatin mu plasma inatsika ndi 38%, ndipo mtengo wapakati wa Tmax mu plasma pamene amatenga liraglutide unakulitsidwa kuyambira 1 mpaka 3 maola.

Liraglutide sizinapangitse kusintha kwawonekera kwa griseofulvin atatha kuyigwiritsa ntchito muyezo umodzi wa 500 mg. Cmax ya griseofulvin inakwera ndi 37%, pomwe phindu la Tmax mu plasma silinasinthe. Mlingo kusintha kwa griseofulvin ndi mankhwala ena okhala otsika solubility ndi mkulu permeability sikofunikira.

Lisinopril ndi digoxin

Kupanga lisinopril mu gawo limodzi la 20 mg kapena digoxin muyezo umodzi wa 1 mg ndikugwiritsa ntchito liraglutide kuwonetsa kuchepa kwa AUC ya lisinopril ndi 15% ndi AUC ya digoxin ndi 16%, Cmax ya lisinopril inatsika ndi 27%, ndi digoxin ndi 31%.

Mtengo wapakati wa Tmax wa lisinopril mu plasma pamene amatenga liraglutide ukuwonjezeka kuchoka pa maola 6 mpaka 8, ndipo mtengo wapamwamba wa Tmax wa digoxin umakwera pansi pazomwezi kuyambira 1 mpaka 1.5 maola.

Kutengera ndi zotsatira zomwe zapezeka, kusintha kwa mankhwalawa kwa lisinopril ndi digoxin pamene mukumwa liraglutide sikofunikira.

Cmax ya ethinyl estradiol ndi levonorgestrel mu limodzi Mlingo wa mankhwalawa liraglutide watsika ndi 12% ndi 13%, motero. M'mikhalidwe yomweyi, Tmax yapakati pa mankhwalawa inali 1.

Patatha maola 5 kuposa masiku onse. Makamaka kwambiri pakukhudzana kwachilengedwe kwa ethinyl estradiol ndi levonorgestrel m'thupi alibe liraglutide.

Chifukwa chake, njira zakulera zomwe onse awiriwa amapangira pochita ndi liraglutide sizisintha.

Warfarin

Kafukufuku wokhudzana ndi kuyenderana kwa mankhwalawa sanachitike. Kumayambiriro kwa chithandizo cha mankhwala ndi Victoza® odwala omwe amalandila warfarin, ndikofunikira kuti azitsatira MHO pafupipafupi.

Kuunika kwa momwe Victoza® imanirana ndi mankhwala a insulin sikunachitike.

Zinthu zomwe zimawonjezeredwa ku Victoza® zimatha kubweretsa kuchepa kwa liraglutide. Popeza maphunziro osakanikirana sanachitidwe, Victoza® sayenera kusakanikirana ndi mankhwala ena.

Zizindikiro zogwiritsidwa ntchito

Malangizo a Victoza ogwiritsira ntchito akuti kuyambika kwa mankhwalawa kuyenera kuchitika ndi milingo yotsika ya mankhwalawa. Chifukwa chake, kuyang'anira kwa metabolic kofunikira kumaperekedwa.

Mukamamwa mankhwalawa, wodwalayo ayenera kuyang'anira kuchuluka kwa shuga m'magazi. Mankhwala omwe amapezeka, komanso kuchuluka kwa jekeseni omwe amaphatikizidwa ndi jekeseni, amatsimikiziridwa ndi adokotala okha. Pankhaniyi, kudzipereka palokha ndi koletsedwa.

Mankhwala Viktoza amaperekedwa kamodzi patsiku, popeza zochita za liraglutide zimayamba kuchitika pakapita nthawi.

Jakisoni wa Victoza amayenera kuperekedwa pansi pa khungu pamalo amodzi osavuta:

Poterepa, jakisoni wa singano samatengera chakudya chachikulu. Monga lingaliro, zimawonedwa kuti ndizoyenera kusunga nthawi yomweyo pakati pa jakisoni. Tiyenera kudziwa kuti mankhwala a Viktoza saloledwa kulowa kudzera m'mitsempha kapena intramuscularly.

Kuchuluka kwa Mlingo woyenera kumadalira kukula kwa kuchuluka kwa matendawo ndi mikhalidwe ya wodwalayo. M'magawo oyamba a chithandizo chamankhwala, tikulimbikitsidwa kupaka jekeseni kamodzi patsiku, womwe udzakhale 0,6 mg wa liraglutide.

Osati kale sabata limodzi chiyambireni kuyambika kwa mankhwala, kuwonjezeka kwa Mlingo mpaka 1,2 mg wa mankhwala patsiku ndikuloledwa. Kukula kulikonse kwa mankhwalawa kuyenera kuchitika ndi masiku osachepera asanu ndi awiri.

Mulingo wambiri wa liraglutide woperekedwa sayenera kupitirira 1.8 mg.

Nthawi zambiri pamankhwala ovuta, mankhwala amagwiritsidwa ntchito molumikizana ndi Metformin kapena mankhwala ena ochepetsa shuga. Pankhaniyi, Mlingo wa mankhwalawa amatsimikiziridwa ndi adokotala.

Monga momwe zamankhwala zimasonyezera, pakuthandizira kwa matenda okalamba mu okalamba, mulingo woperekedwa wa mankhwalawo sunasiyane ndi omwe adanenedwa pamwambapa.

Ndemanga za Victoza za akatswiri azachipatala amawirikiza poti kugwiritsa ntchito mankhwalawa kuyenera kuchitika pokhapokha ngati akuwuzidwa ndi adokotala. Pankhaniyi, mutha kupewa kuwonetsa zotsatira zoyipa ndikusankha mlingo woyenera.

Monga mankhwala ena aliwonse, Victoza ali ndi zotsutsana zingapo kuti agwiritse ntchito.

Ma contraindication onse omwe akupezeka amawonetsedwa mu malangizo ogwiritsira ntchito mankhwalawa.

Ndi achire njira yochizira ndi Viktoza, ndikofunikira kuganizira zonse zotheka zotsutsana ndi ntchito yake.

Amagwiritsidwa ntchito kamodzi patsiku kwa odwala omwe ali ndi matenda a shuga a 2. Imaperekedwa ngati jekeseni wofikira. Masamba a jakisoni ndi: dera lam'mimba, m'chiuno kapena mapewa. Tsamba la jakisoni limatha kusiyanasiyana mosatengera nthawi yankhomaliro. Komabe, kuyambitsa jekeseni nthawi imodzi yamasana, yabwino kwambiri kwa wodwala, ndikulimbikitsidwa.

Mlingo woyamba ndi 0,6 mg tsiku lililonse / masiku 7. Pambuyo pakutha - Mlingo ukuwonjezeka mpaka 1.2 mg. Kafukufuku wazachipatala akuwonetsa kuti odwala ena ali ndi mphamvu zambiri, zomwe zimawoneka ndi mlingo wa 1.2 mpaka 1.8 mg. Mlingo wa tsiku ndi tsiku wa 1.8 mg ndi osavomerezeka.

Mukamapangira othandizira pamodzi ndi Metformin ndi Thiazolidion, mlingo wake sunasinthidwe.

Victoza sulfonylurea zotumphukira - analimbikitsa kuchepetsedwa kwa mankhwalawa pofuna kupewa kupezeka kwa glycemia.

Mlingo wa mankhwala sizitengera zaka. Kusiyana ndi anthu azaka zopitilira 75.Kwa odwala omwe ali ndi vuto lofooka la impso, mlingo umakhalabe womwewo.

Musanagwiritse ntchito mankhwalawa, muyenera kuwerenga mosamala malangizo ndi malamulo ogwiritsira ntchito cholembera ndi syringe.

• kugwiritsa ntchito victoza wozizira,
• Kugwiritsa ntchito singano mobwerezabwereza,
• kusungidwa kwa cholembera ndi singano yomata nayo.

Kutsatira malangizowa kumathandiza kupewa matenda ndikuchepetsa chiopsezo cha mavuto mukabayidwa.

Chithandizo cha mankhwalawa a mankhwalawa amapezeka pakukhazikitsa njira yothetsera vutoli kamodzi patsiku m'matumbo, phewa kapena ntchafu. Nthawi ya jakisoni imasankhidwa popanda kuganizira dongosolo lazakudya. Makamaka chidwi chimakhudzidwa ndikuti majakisoni amayenera kuchitidwa nthawi yomweyo. Mankhwalawa sanapangidwire makonzedwe amkati kapena mtsempha.

Mankhwala amapezeka mu mawonekedwe a yankho, mu 1 ml momwe muli 6 mg yogwira ntchito. Njira yothetsera vutoli imayikidwa mu cholembera 3r yabwino. Wofalitsidwayo amaperekedwa mosavomerezeka m'mimba kapena phewa kamodzi patsiku, makamaka nthawi imodzi. Kumayambiriro kwa chithandizo, mlingo wa mankhwala ndi wochepa kwambiri ndipo ndi 0,6 mg. Kupitilira sabata imodzi kapena iwiri, pang'onopang'ono imachulukitsidwa mpaka 1.8 mg patsiku.

1. Chotsani kapu yakunja yoteteza ku dzanja.
2. Chotsani chopukutira pepala mosamala ndi singano yotaya. Pindani singano pa syringe.
3. Tsopano chotsani kapu yoteteza ku singano, koma osayitaya, koma ayikeni.
4. Ndiye kuchotsa chophimba chamkati chomwe singano ili. Ikhoza kutayidwa.
5. Tsopano yang'anani thanzi la syringe ndikuikonzekeretsa jakisoni woyamba wa kupambana. Izi ndi zofunika kuchita.
6. Tembenuzani mfundo kuti mupeze mlingo. Izi zikuwoneka bwino pakuwonjezeka m'chigawo choyamba.
7. Sinthani syringe ndi singano ndipo pang'onopang'ono tapirani cartridge ndi chala chanu cholozera. Izi ndizofunikira kuti ma thovu am'mlengalenga omwe atengedwa mu cartridge apite.
8. Ndikumangirabe syringe ndi singano mmwamba, kanikizani batani loyambira. Bwerezaninso izi mpaka zero zikuwonekera pazenera ndikuwona dontho la yankho kumapeto kwa singano.
9. Pogwiritsa ntchito mfundo yosankha Mlingo, ikani mlingo womwe umafunikira - 0,6, 1.2 kapena 1,8 mg. Nthawi zambiri, mlingo wocheperako umalimbikitsidwa kuti muchepetse thupi.
10. Tembenuza syringe ndikuyika singano pansi pa khungu. Kanikizani batani loyambira. Gwirani singano mutapanikiza kwa pafupifupi masekondi 5-6.
11. Pang'onopang'ono tulutsani singano.
12. Ikani singano mumkono woteteza (kapu yakunja ya singano, osati yamkati). Yesani kusakhudza singano.
13. Tulutsani singano, iduleni, ndipo mutseke chokhacho ndi chotsekeracho.

S / c pamimba, ntchafu kapena phewa, 1 nthawi patsiku iliyonse, mosasamala kanthu za kudya. Malo ndi nthawi ya jakisoni zimatha kusiyanasiyana popanda kusintha kwa mlingo.

Komabe, ndikofunikira kuperekera mankhwalawa nthawi yomweyo, nthawi yabwino kwa wodwala. Zambiri pazomwe mungagwiritse ntchito mankhwalawa Viktoza® zili mgawo kuti mugwiritse ntchito.

Mankhwala Viktoza ® sangathe kulowa mkati / mu ndi / m.

Kupititsa patsogolo kulekerera kwam'mimba, mlingo woyambirira wa mankhwalawa ndi 0,6 mg wa liraglutide patsiku. Mukatha kugwiritsa ntchito mankhwalawa kwa sabata limodzi, mlingo uyenera kuchuluka mpaka 1.2 mg.

Pali umboni kuti mwa odwala ena, kugwiritsa ntchito mankhwalawa kumawonjezereka ndi kuwonjezereka kwa mankhwalawa kuyambira 1,2 mpaka 1.8 mg. Kuti mukwaniritse bwino kuwongolera kwa glycemic mwa wodwala ndikutengera luso la kuchipatala, mlingo wa Viktoza® ukhoza kuwonjezeka mpaka 1.8 mg mukatha kugwiritsa ntchito mlingo wa 1.2 mg osachepera sabata limodzi.

Kugwiritsa ntchito mankhwalawa tsiku ndi tsiku pamwambapa 1.8 mg ndikulimbikitsidwa.

Mankhwala Victoza® angagwiritsidwe ntchito kuwonjezera pa mankhwala omwe alipo ndi metformin kapena mankhwala ophatikizika ndi metformin ndi thiazolidinedione. Chithandizo cha metformin ndi thiazolidinedione chitha kupitilizidwa pa Mlingo wakale.

Mankhwala Victoza ® amatha kuwonjezeredwa ku mankhwala omwe akupezeka ndi zotumphukira za sulfonylurea kapena kuphatikiza mankhwalawa ndi metformin ndi zotumphukira za sulfonylurea.

Musanagwiritse ntchito cholembera cha Viktoza® Syringe, muyenera kuphunzira mosamala malangizo omwe awonetsedwa.

Victoza® Syringe cholembera ili ndi 18 mg ya liraglutide. Wodwala amatha kusankha chilichonse mwanjira zitatu zotheka: 0.6, 1.2 ndi 1.8 mg. Cholembera cha Victoza® syringe cholinga chake kuti chigwiritsidwe ntchito limodzi ndi singano zotayika NovoFayn ® kapena NovoTvist ® mpaka 8 mm kutalika mpaka 32G (0,25 / 0.23 mm).

Kukonzekera cholembera kuti mupeze jakisoni

Chongani dzina ndi mtundu wazithunzi pa cholembera cholembera kuti mutsimikizire kuti ili ndi liraglutide. Kugwiritsa ntchito mankhwala olakwika kungavulaze thanzi la wodwalayo.

A. Chotsani chipewa mu syringe cholembera.

B. Chotsani pepalalo ndi singano yotaya. Skirani singano mokoma komanso mwamphamvu kukalowa mu cholembera.

C. Chotsani singano yakunja ndikuyiyika pambali osataya.

D. Chotsani thumba lamkati la singano ndikuitaya.

Chidziwitso chofunikira. Nthawi zonse gwiritsani ntchito singano yatsopano ndi jakisoni aliyense. Kuchita koteroko kumalepheretsa kuipitsa, kufalitsa, kutulutsa mankhwalawa ku cholembera, kuthana ndi singano ndikutsimikizira kulondola kwa dosing.

Chidziwitso chofunikira. Yang'anani mosamala pakugwirira singano kuti mupewe kuwononga kapena kuwononga singano musanagwiritse ntchito.

Malinga ndi malangizo ogwiritsira ntchito, Viktoza amaperekedwa kwa odwala akuluakulu omwe ali ndi matenda a shuga 2 omwe amadya, azichita masewera olimbitsa thupi. Kuti mukwaniritse kuyang'anira glycemic, ndikulimbikitsidwa:

• monotherapy
• kuphatikiza ndi othandizira ochepetsa shuga mu mawonekedwe a mapiritsi (thiazolidinediones, sulfonylureas, metformin), pokhapokha ngati palibe zotsatira zochokera pamankhwala apitawo a mankhwala,
• kuphatikiza ndi basulin insulin, ngati sizingatheke kukwaniritsa kuwongolera kwa glycemic ndikukhazikitsa liraglutide, kutenga metformin.

Kusankha kwa mankhwala ochizira CD-2 kumapangidwa ndi endocrinologist. Popereka mankhwala a Victoza, poyamba madokotala amalimbikitsa kuyika 0,6 mg yogwira ntchito patsiku. Pambuyo pa sabata la mankhwalawa, mlingo umakwera ku 1,2 mg. Kuunikiridwa kwa madokotala kumawonetsa kuti kuwunika momwe wodwalayo akufunikira.

Mlingo wothandiza kwambiri ndi 1.8 mg wa liraglutide. Ndalamazi ndizokwanira kuwongolera kwambiri matenda ashuga.

Wodwala ayenera kugwiritsa ntchito zolembera. Popanda chidziwitso, endocrinologist amathandizira kudziwa momwe angagwiritsire ntchito mankhwalawa moyenera.

Wodwalayo amapangira jakisoni wochepetsetsa mu ntchafu, m'mimba kapena phewa. Malowa amasankhidwa mosadalira. Njira yoyendetsera ikuyenera kukhalabe yosasinthika, malo omwe jakisoni amapangidwira, kapena nthawi ya jakisoni imaloledwa kuti isinthe.

Cholembera cha syringe chimagwiritsidwa ntchito limodzi ndi singano zomwe zimakwanira, NovoTvist ndi NovoFayn. Pamaso oyamba oyamba, werengani momwe mungafotokozere. Nthawi iliyonse muyenera kugwiritsa ntchito singano yatsopano. Izi zimalepheretsa kuipitsidwa kwa mankhwalawa, kutayikira kuchokera kumphatso. Kubwezeretsa singano pafupipafupi ndi chitsimikizo cha dosing yolondola.

Ndiosavuta kuwerengera kuchuluka kwa syringe imodzi yokwanira, kudziwa kuchuluka kwa mankhwalawa omwe amayenera kuperekedwa. Izi zimatengera mwachindunji mlingo womwe dokotala wakhazikitsa. Ngati wodwala agwiritsa ntchito njira yochiritsira yomwe 1.8 mg ya liraglutide imayendetsedwa tsiku lililonse, ndiye kuti cholembera 1 chokwanira jakisoni khumi.

Victoza adalembedwa kuti azilamulira shuga m'magazi omwe ali ndi matenda a shuga a 2. Itha kuphatikizidwa ndi metformin kapena njira zina monga momwe adokotala amafotokozera.

Kugwiritsa ntchito mosavuta kugwiritsa ntchito mankhwalawa kamodzi kwa maola 24. Jakisoni amaloledwa kuchitidwa mosazindikira mu ntchafu, phewa kapena pamimba. Jakisoni alibe chakudya. Ndikofunika kuti muzisamala pakati pa jakisoni. Njira yothetsera vutoli sayenera kutumikiridwa kudzera m'mitsempha kapena m'mitsempha.

Kumayambiriro kwa mankhwalawa, mlingo ndi 0.6 mg wa liraglutide mu maola 24. Pambuyo masiku osachepera 7 ogwiritsira ntchito, mlingo umakulitsidwa kwa 1.2 mg patsiku.

Pali chidziwitso chakuti kugwiritsa ntchito mankhwalawa nthawi zambiri kumawonekera mukamapereka mankhwala muyezo wa 1.2 - 1.8 mg mu maola 24. Kukhazikitsidwa kwa mlingo wa 1.8 mg kumachitikanso pambuyo masiku 7 a mlingo wa 1.2 mg.

Ndiosafunika kupitilira muyeso wa tsiku ndi tsiku wa 1.8 mg wa liraglutide.
.

Viktozu nthawi zambiri amaphatikizidwa ndi metformin kapena mankhwala ena. Mlingo woyenera wa ndalamazi uyenera kufotokozedwanso ndi dokotala.

Kuyesedwa kwa magazi kwa nthawi ndi nthawi kumalembedwa kwa odwala, makamaka pochiza ndi Viktoza limodzi ndi mankhwala ena.

Mukakalamba, mlingo samasiyana ndi zomwe tafotokozazi. Odwala okha omwe ali ndi zaka zosaposa 75 zakubadwa amafunika kuwonjezeredwa chisamaliro pa mankhwala.

Pakulephera kwa aimpso, ndi kufatsa, kusintha kwa mankhwalawa sikofunikira. Kulephera kwakukulu kwa aimpso, Victosa amatsutsana. Komanso, palibe wothandizila amene amapatsidwa gawo lililonse la chiwindi kulephera.

Mpaka azaka 18, Viktoza sanasankhidwe. Palibe chidziwitso pakugwiritsa ntchito m'badwo uno.

Mankhwalawa amaperekedwa kamodzi patsiku, subcutaneally, pamimba, phewa kapena ntchafu, osasamala chakudyacho. Ndikulimbikitsidwa kuti mupeze jakisoni ndi mankhwala a Victoza (malangizo omwe angagwiritsidwe ntchito amafotokozera mwatsatanetsatane njira yogwiritsira ntchito mankhwalawa) nthawi yomweyo. Mankhwalawa sangathe kugwiritsidwa ntchito pakuwongolera makonzedwe amtsempha makamaka pakhungu la intravenous.

Mlingo woyambirira watsiku lililonse wa wothandizirawu suyenera kupitirira 0,6 mg. Pang'onopang'ono, kupitirira sabata limodzi, amawonjezeredwa ku 1.2 mg. Ngati ndi kotheka, ndiye kuti pamasiku 7 otsatirawa, onjezerani pang'onopang'ono mlingo mpaka 1,8 mg. Mlingo wa tsiku ndi tsiku wa 1.8 mg ndiwovomerezeka kwambiri.

Madokotala amalangiza Victoza yankho kuti athandizire chithandizo cha metformin. Ndikulimbikitsidwa kuti muzigwiritsa ntchito limodzi ndi metformin ndi thiazolidinedione. Mlingo wa mankhwala aposachedwa sangasinthidwe.

Malinga ndi malangizo, Viktoza amagwiritsidwa ntchito pa matenda a shuga 2 kuphatikiza zakudya komanso masewera olimbitsa thupi kuti akwaniritse kuwongolera kwa glycemic.

Njira zotheka kugwiritsa ntchito mankhwalawa:

• monotherapy
• kuphatikiza chithandizo chamankhwala amodzi kapena angapo amkamwa hypoglycemic othandizira (thiazolidinediones, sulfonylureas, metformin) mwa odwala omwe alephera kukwaniritsa bwino glycemic nthawi ya chithandizo cham'mbuyomu,
• kuphatikiza mankhwala a basal insulin odwala omwe alephera kukwaniritsa bwino glycemic control pogwiritsa ntchito Victoza osakanikirana ndi metformin.

Victoza amayenera kutumikiridwa mosabereka m'mimba, phewa kapena ntchafu kamodzi patsiku, ngakhale zakudya. Malo ndi nthawi ya jekeseni imatha kusinthidwa popanda kusintha kwa mlingo, komabe, ndikofunikira kuperekera mankhwalawa pafupifupi nthawi yomweyo, yomwe ili yabwino kwambiri kwa wodwalayo.

Kupititsa patsogolo kulekerera kwamatumbo, chithandizo chimalimbikitsidwa ndi mlingo wa tsiku lililonse wa 0,6 mg. Pambuyo pa sabata yochepa, mlingo umakulitsidwa ku 1,2 mg. Ngati ndi kotheka, pofuna kukwaniritsa njira yabwino kwambiri yolamulira glycemic, poganizira luso la Victoza, kuwonjezeka kwa mlingo mpaka 1.8 mg ndikotheka patatha sabata limodzi. Kugwiritsa ntchito Mlingo wapamwamba sikulimbikitsidwa.

Mankhwalawa amatha kuikidwa kuwonjezera pa mankhwala omwe akupezeka ndi metformin kapena kuphatikiza mankhwala ndi metformin osakanikirana ndi thiazolidinedione. Mlingo womaliza suyenera kusintha.

Wowonongera amatha kuwonjezeredwa ku mankhwala omwe alipo a sulfonylurea kapena mankhwala a metformin osakanikirana ndi mankhwala a sulfonylurea. Pankhaniyi, kuti muchepetse mwayi wokhala ndi hypoglycemia yosafunikira, mlingo wa zotumphukira za sulfonylurea ziyenera kuchepetsedwa.

Kwa odwala omwe ali ndi zaka zopitilira 75, mankhwalawa akuyenera kuchitika mosamala.

Palibe kusankha kwa mankhwalawa kwa odwala omwe ndi ofatsa aimpso. Palibe chidziwitso chochepa pakugwiritsa ntchito mankhwalawa odwala omwe ali ndi vuto la aimpso. Pakadali pano, kugwiritsa ntchito mankhwala Victoza® kwa odwala omwe ali ndi vuto laimpso, kuphatikizapo Odwala ndi mathero aimpso kulephera, kutsutsana.

Pakadali pano, pali zochepa zomwe zimagwiritsidwa ntchito ndi mankhwalawa Victoza® odwala omwe ali ndi vuto la chiwindi, motero amadziwikiratu kwa odwala omwe ali ndi vuto lochepa kwambiri la chiwindi.

Contraindication

Amasankhidwa ndi katswiri wowachiritsa ngati chida chowonjezera.

Mankhwala othandizira kukhazikitsa shuga komanso:

• Metformin kapena zotumphukira zochokera kwa sulfonylurea mwa odwala omwe ali ndi chindoko chochepa cha glycemic, ngakhale mulingo wambiri wololera wa zinthu izi mu monotherapy,
• Metformin kapena mankhwala a sulfonylurea kapena Metformin ndi Thiazolidinediones odwala omwe ali ndi index yotsika ya glycemic, ngakhale akupanga zovuta za mankhwala 2.

Chizindikiro chachikulu cha kugwiritsa ntchito mankhwala a Viktoza ndi matenda a shuga a 2. Kwa odwala otere, yankho limatha kutumikiridwa ngati mankhwala odziimira pawokha, kapena ngati gawo la zovuta la mankhwala omwe ali ndi pakamwa hypoglycemic othandizira, otchuka kwambiri omwe ndi Diabetalong, Glibenclamide ndi Metformin.

Kuphatikiza apo, adotolo angalembe mankhwala a Viktoza monga gawo la zovuta mankhwala omwe ali ndi insulini pochitika kuti, chifukwa chogwiritsa ntchito mitundu isanachitike ya mankhwala, zotsatira zake sizinachitike.

Ngakhale mutagwiritsa ntchito mankhwalawa, kuwonjezera pakumwa, wodwalayo ayenera kutsatira zakudya zapadera ndikukhalabe ndi masewera olimbitsa thupi.

Sizovomerezeka kupereka mankhwalawa kwa odwala omwe ali ndi matenda a shuga 1, komanso kwa anthu omwe ali ndi hypersensitivity ofunikira pazigawo zikuluzikulu za mankhwalawa. Amaletsedwanso kuti azimayi azigwiritsa ntchito panthawi yoyembekezera komanso pakubala.

Zina zotsutsana mwamtheradi pakusankhidwa kwa mankhwalawa ndi maresi a m'mimba, kuperewera kwa mtima, colitis, ketoacidosis. Ndi zoletsedwa kugwiritsa ntchito mankhwalawa kwa odwala osakwana zaka 18.

Zotsatira zoyipa izi zitha kuchitika mu chithandizo cha Victoza:

• kusokonezeka kwam'mimba thirakiti (m'mimba, kusanza ndi mseru),
• hypoglycemia (dontho la kuchuluka kwa shuga m'magazi m'munsi moyenerera),
• mutu.

Contraindication yogwiritsira ntchito Victoza, yonse yokhudza kuwonda komanso mankhwala:

• kwambiri aimpso ndi kwa chiwopsezo cha hepatic,
• mtundu 1 shuga
• mimba ndi mkaka wa m`mawere
• wazaka 18.

- kuphatikiza mankhwalawa pogwiritsa ntchito mankhwala amodzi kapena angapo a hypoglycemic (omwe ali ndi metformin, sulfonylureas kapena thiazolidinediones), mwa odwala omwe sanakwanitse kuwongolera glycemic koyambirira kwamankhwala.

- kuphatikiza mankhwala ndi insal insulin mwa odwala omwe sanakwanitse kuwongolera glycemic nthawi ya mankhwala ndi Victoza ® ndi metformin.

Hypersensitivity ku chinthu yogwira kapena zinthu zina zomwe zimapanga mankhwala,

mbiri ya khansa ya chithokomiro ya medullary, kuphatikizapo banja

angapo endocrine neoplasia mtundu 2.

matenda ashuga ketoacidosis (onani "Malangizo apadera"),

mimba ndi nthawi yoyamwitsa (onani. Gwiritsani ntchito panthawi yovomerezeka ndi mkaka wa m'mawere "),

kuvulala kwambiri aimpso,

chiwindi ntchito,

Ntchito ya kalasi III - Kulephera kwamtima kwa IV (malinga ndi NYHA (New York Cardiology Association) gulu,

Victoza sayenera kutumizidwa pazinthu ngati izi komanso matenda:

• mimba
• Hypersensitivity onse othandizira othandizira komanso chilichonse chothandiza,
• nthawi yoyamwitsa,
• matenda ashuga ketoacidosis,
• kulephera kwa chiwindi
• mtundu 1 shuga
• kuyendetsa bwino kwamikodzo,
• kulephera kwa mtima
• wazaka 18
• paresis am'mimba
• Matumbo matenda a kutupa chikhalidwe.

Muyenera kusamala pochiza Victoza kwa odwala omwe ali ndi giredi 1 mpaka 2 kulephera kwa mtima, osatchulidwa kuwonongeka kwa impso kapena chiwindi, komanso kwa odwala omwe ali ndi zaka zopitilira 75.

Mankhwala "Victoza" (malangizo ndi kuwunika akuwunikira za kufunsa kwa dokotala musanagwiritse ntchito mankhwalawa) amalembera mtundu wachiwiri wa matenda a shuga. Pankhaniyi, yankho likhoza kugwiritsidwa ntchito limodzi ndi monotherapy komanso ndi chithandizo chovuta ndi othandizira pakamwa hypoglycemic, monga Dibetolong, Glibenclamide ndi Metformin.

"Victoza" wina ungagwiritsidwe ntchito popanga zovuta ndi insulin, ngati kugwiritsa ntchito mankhwala osakanikirana kale sikunapeze zotsatira.

Pazonse zomwe takambirana pamwambapa, chithandizo chamankhwala chiyenera kutsagana ndi chithandizo chamankhwala komanso zolimbitsa thupi.

Mankhwala ndi oletsedwa kugwiritsidwa ntchito mwa mtundu woyamba wa matenda a shuga, komanso ngati pali Hypersensitivity pamagawo a mankhwalawa. Simungathe kugwiritsa ntchito mankhwalawa panthawi yapakati komanso panthawi yoyamwitsa.

Contraindication kuti agwiritse ntchito ndi ketoacidosis, colitis, mtima kulephera ndi paresis ya gastric organ. Sikulimbikitsidwa kusankha "Vicose" kwa anthu ochepera zaka 18.

Victoza® imawonetsedwa ngati cholowera pakudya ndi masewera olimbitsa thupi kuti akwaniritse kuwongolera kwa glycemic kwa odwala omwe ali ndi matenda a shuga a 2. Victoza ® akuwonetsedwa pophatikiza mankhwala kuti akwaniritse kuwongolera kwa glycemic ndi:

• metformin kapena sulfonylurea zotumphukira odwala osakwanira glycemic,
• ngakhale mulingo wololera kwambiri wa mankhwala a metformin kapena sulfonylurea mu monotherapy,
• metformin ndi sulfonylurea zotumphukira kapena metformin ndi thiazolidinediones mu odwala omwe ali ndi vuto lokwanira glycemic,
• ngakhale kuphatikiza mankhwala ndi mankhwala awiri.

• mtundu 1 shuga
• matenda ashuga ketoacidosis,
• mimba
• nthawi yoyamwitsa,
• Hypersensitivity ku chinthu yogwira kapena zinthu zina,
• gawo la mankhwala.

Victoza: ndemanga

Malinga ndi umboni wa odwala matenda ashuga, omwe endocrinologist adalimbikitsa jekoglutide, mankhwalawa amathandizira kuchepetsa chiwonetsero cha DM-2, amachepetsa kwambiri kuchuluka kwa shuga.

Anthu ena amadandaula zotsatirazi zotsatirazi za hypoglycemic wothandizira: nseru, kusanza koyambirira. Popita nthawi, mawonekedwe osayenerawa amapita popanda kufufuza. Koma odwala ambiri amalekerera bwino mankhwalawo.

Ngati Viktoza sathandiza, ndiye kuti kuyika jakisoni imodzi sikokwanira. Zikatero, insulin imaperekedwanso. Poyerekeza ndi ndemanga za odwala, kuphatikiza chithandizo ndikothandiza kwambiri mukamadya zakudya ndikuchita masewera olimbitsa thupi.

Ndemanga za Viktoz ndizabwino. Fotokozani kuti mukamagwiritsa ntchito mankhwalawa odwala omwe ali ndi matenda a shuga 2, amachepetsa chidwi cha kudya komanso kuchepa kwa thupi. Zotsatira zake, thanzi lathu lonse limayenda bwino ndipo zochitika zolimbitsa thupi zimawonjezeka. Zosakwanira zochizira kapena kusakhalapo kwake sikunenedwe zambiri. Mtengo wa Victoza akuti ndiwokwera kwambiri.

Kutulutsa mawonekedwe ndi kapangidwe kake

Thupi liraglutide amadziwika ngati yogwira pophika. Zomwe zili mu 1 ml zimafika pa 6 mg. Syringe imodzi - cholembera chimakhala ndi kuchuluka kwa mankhwala a 3 ml, omwe ali ndi 18 mg ya liraglutide. Zothandiza zothandizira zimayimiriridwa ndi propylene glycol, hydrochloric acid, phenol, sodium hydrogen phosphate dihydrate, madzi a jekeseni.

Katakata yachiwiri ikhoza kukhala ndi syringe 3, 2 kapena 1 - cholembera chopangidwa ndi pulasitiki. Kitayo imaphatikizaponso malangizo atsatanetsatane.

Mankhwala

Liraglutide ndi analogue ya glucagon yofanana ndi peptide-1 (GLP-1), yopangidwa ndi recombinant DNA biotechnology pogwiritsa ntchito Saccharomyces cerevisiae strain, yomwe ili ndi 97% ya Homology ya anthu ndi GLP-1, yomwe imamangiriza ndikuyambitsa zolandila za GLP-1 mwa anthu. Receptor ya GLP-1 imagwira ntchito ngati chandamale cha mbadwa za GLP-1, ma endreteni am'magazi amkati, omwe amachititsa kuti shuga azidalira shuga m'magazi a pancreatic beta. Mosiyana ndi mbadwa za GLP-1, ma pharmacokinetic ndi ma pharmacodynamic Mbiri ya liraglutide amalola kuti ziziperekedwa kwa odwala tsiku lililonse 1 nthawi patsiku.

Mothandizidwa ndi liraglutide, kukhudzana ndi shuga kwa insulin katulutsidwe kumachitika. Nthawi yomweyo, liraglutide imapumira shuga wambiri wodalira shuga. Chifukwa chake, ndi kuchuluka kwa kuchuluka kwa shuga m'magazi, insulin katulutsidwe imakhudzidwa ndipo katulutsidwe wa glucagon amakakamizidwa. Komabe, pa hypoglycemia, liraglutide amachepetsa katemera wa insulin, koma sayimitsa katulutsidwe wa glucagon. Njira yochepetsera glycemia imaphatikizanso kuchepetsedwa pang'ono kwa madzi am'mimba. Liraglutide amachepetsa thupi komanso amachepetsa mafuta m'thupi ndi zinthu zomwe zimapangitsa kuchepa kwa njala komanso kugwiritsa ntchito mphamvu zochepa.

Malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwala a Viktoza amaperekedwa mwachangu 1 nthawi / tsiku m'mimba, ntchafu kapena phewa. Tsamba ndi jakisoni ndi nthawi zimatha kusinthidwa popanda kusintha kwa mlingo. Komabe, ndikofunikira kuperekera pafupifupi nthawi yomweyo, panthawi yabwino kwambiri kwa wodwala. Osalowe / kulowa kapena / m.

1. Mlingo woyambayo ndi 0,6 mg / tsiku. Pambuyo pakugwiritsa ntchito kwa sabata limodzi, mankhwalawa ayenera kukulitsidwa mpaka 1.2 mg. Pali umboni kuti mwa odwala ena, kugwiritsa ntchito mankhwalawa kumawonjezereka ndi kuwonjezereka kwa mankhwalawa kuchokera ku 1,2 mg mpaka 1.8 mg. Kuti mukwaniritse bwino kuwongolera kwa glycemic mwa wodwala ndikuthana ndi luso lachipatala, mlingowo ukhoza kuwonjezeka mpaka 1.8 mg mutatha kugwiritsa ntchito mlingo wa 1.2 mg kwa sabata limodzi. Gwiritsani ntchito tsiku lililonse mankhwala opitilira 1.8 mg osavomerezeka.
2. Ndikulimbikitsidwa kugwiritsa ntchito kuwonjezera pa mankhwala omwe alipo ndi metformin kapena kuphatikiza kwa mankhwala ndi metformin ndi thiazolidinedione. Chithandizo cha metformin ndi thiazolidinedione chitha kupitilizidwa pa Mlingo wakale.

Tikulimbikitsidwa kuti tiwonjezere liraglutide pakanthawi pano ndi mankhwala a sulfonylurea kapena kuphatikiza mankhwala ndi metformin ndi zotumphukira za sulfonylurea. Pamene liraglutide ikawonjezeredwa ku mankhwala omwe amapezeka ndi sulfonylurea, kuchepetsa kwa mankhwala a sulfonylurea kuyenera kuganiziridwanso kuti muchepetse chiopsezo cha hypoglycemia.

Zotsatira zoyipa

Victoza atha kukhala ndi vuto pa machitidwe ena ndi ziwalo zina. Itha kuchitika:

1. Kuchokera kumbali yamtima: nthawi zambiri - kuchuluka kwa mtima,
2. Pa khungu ndi subcutaneous zimakhala: zambiri - zotupa, wosakhalitsa - kuyabwa, urticaria,
3. Kuchokera ku chitetezo chamthupi: kawirikawiri (≥ 1/10 000 asanafike bongo

Mothandizidwa ndi kuyamwa kwa mankhwala opitilira 40 mgyezo wamba, nseru kwambiri ndi kusanza zimayamba. Chithandizo cha Syndrome chimachitika.

Malangizo apadera

Palibe zambiri pazokhudza Victoza pa amayi apakati. Komabe, mu maphunziro a nyama, zidapezeka kuti mankhwalawa ali ndi poizoni wobereka. Pa mimba, insulin mankhwala tikulimbikitsidwa, Woponderezedwa contraindicated. Ngati mimba yongokonzekera kapena nthawiyo ndi yochepa, ndiye kuti jakisoni wa Victoza aletsedwa. Ayenera kuyimitsidwa nthawi yomweyo.

Kulowa kwa liraglutide kulowa mkaka wa amayi oyamwitsa kuli kochepa, Viktoza sichikudziwika panthawiyi.

Kuyanjana kwa mankhwala

Wovutitsidwayo amatha kuthandizira kuchepetsedwa pang'ono m'mimba, zomwe zimapangitsa kusintha kwa mankhwalawa am'kamwa. Malinga ndi kafukufuku, izi sizikhala ndi phindu lililonse m'thupi, motero kusintha kwa mankhwalawa sikofunikira. Zovuta zapadera za matenda am'mimba pazakumwa ndi liraglutide amadziwika (zingakhudze mayamwidwe amodzi omwe amagwiritsidwa ntchito pakamwa panthawi yomweyo).

Pogwiritsa ntchito warfarin kapena zotumphukira zina za coumarin, ndikofunikira kuyang'anira INR pafupipafupi (International Normalized Ratio).

Zinthu zomwe zimawonjezeredwa ku Viktoza zimatha kubweretsa kuchepa kwa liraglutide, chifukwa chake siziyenera kusakanikirana ndi mankhwala ena, kuphatikizapo njira zobayira.

Tidalemba ndemanga za anthu za mankhwala a Victoza:

1. Timur. Ndili ndi matenda ashuga 2. Victoza m'mwezi umodzi adachepetsa shuga kuchokera pa 10 mpaka 7.2. Kulemera sikunasinthe. Koma chithokomiro cha prostate chachulukanso. Sindikudziwa ngati pali kulumikizana kapena ayi, koma kutchulidwa kwa chiwopsezo cha khansa ya chithokomiro ndikosangalatsa.
2. Svyatoslav. Type 2 shuga mellitus, insulini imakhala yochulukirapo, palibe mankhwala amodzimodzi omwe amaloledwa kukhazikika komanso kumva bwino. Zomwe zinali zochititsa manyazi kwambiri zinali zopanda pake komanso zolimbitsa thupi zomwe zinkakula. Dokotala wanga atandilamula kuti andipatse Victoza, zinthu zinasintha kwambiri. Ndinkamva mphamvu komanso mphamvu zambiri, ndinalibe chakudya. Kwa sabata loyamba, nthawi yomweyo adataya 2 kg. Zizindikiro za shuga zabwerera ku zinthu zomwe sizinachitike, komabe pali ntchito yoti ichitike. Munakumana ndi zovuta zina - nthawi zina mutu. Koma iyi ndi mphotho yomwe simulabadira, mumamvanso ngati munthu wathunthu komanso wathanzi.
3. Olga Ndakhala ku Viktoz kwazaka zopitilira 2. Kuchepetsa thupi ndikulimbitsa kagayidwe. Shuga amakhala wangwiro nthawi zonse. Imasokoneza mtengo wokwera, koma muyenera kulipira kuti mutonthozedwe komanso thanzi. Dotoloyo wapereka ma fanizo otsika mtengo omwe ndi osavuta kugwiritsa ntchito, ndipo zotsatira za mankhwalawo zimawoneka kuti ndizosagwirizana ndi zomwe zotsatira za Viktoza zidakwaniritsidwa. Sanakonzekere kusiya mankhwala abwino.
4. Victoria Ndinafika kwa endocrinologist kumapeto kwa Novembara 2016. Mlingo wa shuga ndiye 10-1 mol. Ndi kukula kwa 172 kulemera makilogalamu 103. Zakudya za zakudya, Glucophage ndi Victoza zidalembedwa. Pambuyo pa milungu itatu yamankhwala okhwima, shuga idabwezeretsa zonse. Anayamba kuchepa thupi kuyambira sabata lachiwiri la chithandizo. Pakupita miyezi iwiri, zinali zotheka kutaya 15 kg. Tsopano msuzi wa shuga ndi wokhazikika ndipo ndi 5.3 mol.

Mankhwala otsatirawa ndi ofanana mu zotsatira zawo zamankhwala, koma ndi mankhwala ena:

1. Baeta ndi mankhwala osokoneza bongo omwe amadziwika kuti ndi othandizira polimbana ndi zovuta za matenda a shuga. Amapezeka mu mawonekedwe a yankho la subcutaneous jakisoni. Chofunikira chachikulu ndi exenatide. Mtengo wamba wa mankhwalawa m'masitolo ndi ma ruble 4,000.
2. Novonorm ndi piritsi lomwe limakhala ndi kuchepetsa shuga m'thupi. Wopanga mankhwalawa ndi Germany. Chofunikira chachikulu pa chinthu ndi mankhwala. Nthawi zambiri amagwiritsidwa ntchito posagwiritsa ntchito mankhwala osokoneza bongo omwe amadalira shuga, monga chida chachikulu kapena kuphatikiza mankhwala ndi metformin kapena thiazolidinedione. Mtengo wa mankhwalawa, kutengera mlingo, umasiyana kuchokera ku ma 170 mpaka ma ruble 230.

Musanagwiritse ntchito fanizo, funsani dokotala.

Momwe mungatenge Victoza mu mtundu wa 2 matenda ashuga - maupangiri ndi zidule pa News4Health.ru

Moyo wamasiku ano uli ndi zambiri zomwe zimakhudza thanzi la munthu. Zomwe zikuluzikulu ndizoyambira zachilengedwe, zakudya zokayikitsa, madzi akumwa osokoneza, chithandizo chamankhwala chosavomerezeka, komanso zovuta komanso zikhalidwe zoipa. Chifukwa chake, ndikofunikira kulabadira kuchiritsidwa kwakuthupi kwa thupi pogwiritsa ntchito njira zosiyanasiyana. Onetsetsani kuti mwakumana ndi katswiri kuti asawononge thanzi lanu!

Zokhudza mankhwalawa

Matenda a shuga ndi mkhalidwe womwe ubale wa insulin (mahomoni a kapamba) ndi shuga (zakudya zomwe zimabwera ndi chakudya m'thupi) zimasokonekera. Zotsatira za kulumikizidwa kwathyo ndi hyperglycemia. Wogwiriridwa ndi mankhwala omwe mankhwala ake amagwira ntchito amathandizira glucagon-ngati peptide-1 receptors ndikuwonjezera katemera wa insulin.

Mankhwala ndi a njira zaposachedwa kwambiri pochizira matenda a shuga a 2. Gawo logwira (liraglutide) lili pafupi kwambiri ndi insulin yachilengedwe, chifukwa chake limakhala ndi chithandizo chachikulu.

Wothandizira wa hypoglycemic adapangira makatani osokoneza. Nditalandira gawo logwira, zotsatirazi zimachitika:

• kapamba amayambitsa,
• kuchuluka kwa insulin,
• kuchuluka kwa maselo a beta kumachuluka
• kumverera kwanjala kumachepera.

Mu zovuta, zonsezi zimabweretsa kukula kwa shuga. Khalidwe lofunikanso la Victoza ndikupewa kufa kwa maselo omwe akuwoneka, omwe amatsogolera pakukula kwakanthawi kwa endocrine pathology.

Chifukwa cholumikizana ndi mapuloteni am'madzi am'magazi, mphamvu ya mankhwalawa imasungidwa kwa maola 24. Zinthu zomwe sizikuyenda sizisintha ndipo zimatha kudziunjikira, chifukwa zimachoka m'thupi pakatha masiku 8.

Kuyembekezera kugwiritsa ntchito Victoza

Wogulitsa mankhwala ali ndi zinthu zingapo zabwino (kuwonjezera pa zochita za hypoglycemic), kufunika komwe kumadza ndi vuto la endocrine.

• kusintha kwa magazi kumankhwala ndi ziwalo,
• malamulo am'mimba
• kuthamanga kwa magazi,
• kupangidwa kwa glucagon ndi minyewa ya chiwindi pamitengo yoyenera,
• zimagwira ntchito kwamikodzo.

Zinthu zothandizirana zikagwira ndi hypothalamus, kufunitsitsa kosatha "kudya" kumachepetsedwa, popeza wodwalayo amakhala ndi mtima wokhutira panthawi ya chithandizo.

Zotsatira zoyipa

Therapy yokhala ndi liraglutide imayendera limodzi ndi kutukuka kwa zoyipa kuchokera m'matumbo ndi mitsempha ya m'mimba. Mwina kuwoneka kusanza, kunyansidwa, kutsegula m'mimba kapena kupweteka m'mimba pambuyo pakukonzekera kwa mankhwalawa. Mutu ndi chizungulire sizimalamulira. Zowonekeranso:

• achina,
• zolimbitsa mphamvu zapakati
• kuchepa kapena kusowa kwa chakudya,
• kunenepa kwambiri
• thupi lawo siligwirizana pa malo jakisoni.

Ndizachilendo kwambiri (koma osaphatikizidwa) kuti pali zovuta kupuma komanso matenda opatsirana thirakiti.

Bongo

Kuchulukitsa ndende yomwe yakhazikitsidwa - kumabweretsa njira zochulukirapo zamavuto. Zizindikiro zamankhwala zimawoneka ngati kusanza komanso kupwetekedwa mutu. Mwazi wamagazi amachepa, hypotension siyipatula. Kuti mawonedwe azizindikiro zotere, kuchuluka kwake kuyenera kuwonjezereka nthawi 40.

Kwambiri komanso mndandanda wazovuta za zotsutsana ndi malo osakira ma Victoza, ngakhale atachita bwino. Zodziwika mu kapangidwe kake ndi chisonyezo chogwiritsidwa ntchito ndi liraglutide. Analogue imagwiritsidwa ntchito kawiri patsiku ndipo imakhala ndi zochepa zotsutsana. Liraglutid-Baeta nthawi zambiri imagwiritsidwa ntchito pakuchepetsa thupi, koma imakhala ndi zovuta zina.

Analogue ina yomwe ikupezeka ndi Saxenda.Dokotala yekha ndi amene angasankhe kuti ndiyani wabwino, chifukwa mankhwalawa onse ali ndi mndandanda wa zotsutsana ndi zoyipa. Saksenda - chinthu chomwe chimagwiritsa ntchito makina osunthira, ali ndi chinthu chofanana, komabe, ndizosavuta kugula mankhwala.

Ndemanga Zahudwala

Inna Zh. "Adotolo andipangira Victoza osakanikirana ndi mapiritsi a shuga. Ndimazindikira nthawi yomweyo - zisonyezozo zidabweranso pambuyo pofika masiku 7, pamene mlingo wake udachulukitsidwa. Ndine wokhutira ndi zomwe zachitika, kuphatikiza kunenepa. ”

Gennady R. "Sindinachite bwino ndi Victoza kwa 1 chaka chimodzi (matenda a shuga zaka 4). Nthawi zambiri ndinayiwala kuti shuga wamkulu ndi chiyani. "

Pomaliza, zitha kudziwika kuti mankhwalawa, ngakhale anali okwera mtengo, amagwiritsidwa ntchito mosamala pochiza matenda ashuga. Zotsatira zoyipa sizimachitika kawirikawiri, ndipo nthawi zambiri chifukwa chonyalanyaza zikhalidwe za contraindication. Victoza pochiza matenda a shuga a mtundu wachiwiri, koma osagwirizana ndi kumwa mankhwala kuti muchepetse kunenepa.