Emoxibel mankhwala: malangizo ntchito > Chithandizo ndi kupewa

Mlingo wa kutulutsidwa kwa Emoxibel:

Njira yothetsera kulowetsedwa: kopanda utoto, wowonekera (m'mabotolo agalasi a 100 ml, pabokosi lamatabwa 1),
Njira yothetsera kulowetsedwa kwa mtsempha (i / v) ndi makulidwe a intramuscular (i / m): wowoneka bwino kapena wopanda utoto, wowoneka bwino (mu milu 10 ml, mu 5 ml ampoules, mumagulu amatumba a ma ampoules 5, pamakatoni a 1 kapena 2 ma CD kapena botolo limodzi),
Maso akutsikira: ndi tint wachikasu kapena wopanda utoto, wowonekera (m'mabotolo a 5 ml, pabotolo lalikulu la makatoni),
jakisoni: wopanda utoto, wowonekera (m'mapulogalamu a 1 ml, m'matumba ambiri a ma 5 ampoules, pamakatoni okhala ndi ma ampoules 10 kapena 1 kapena 2 yamatumba omwe ali ndi vuto lochulukirapo).

Kuphatikizidwa kwa 1 ml Emoxibel kulowetsedwa Solution:

yogwira mankhwala: methylethylpyridinol hydrochloride (emoxypine) - 0,005 g,
zothandizira: madzi a jakisoni, sodium chloride.

Muli 1 ml ya yankho la iv ndi mu mnofu makonzedwe a Emoxibel:

yogwira mankhwala: methylethylpyridinol hydrochloride (emoxypine) - 0,03 g,
zothandiza: madzi a jakisoni, sodium hydrogen phosphate dodecahydrate, sodium sulfite.

Muli madontho 1 ml a Ophthalmic Emoxibel:

ntchito yogwira: methylethylpyridinol hydrochloride (emoxypine) - 0,01 g,
othandizira: madzi a jakisoni - mpaka 1 ml, sodium hydrogen phosphate dodecahydrate - 0,007 5 g, potaziyamu dihydrogen phosphate - 0,006 2 g, sodium benzoate - 0,002 g, sodium sulfite - 0,003 g.

Kupanga 1 ml Emoxibel jekeseni:

ntchito yogwira: methylethylpyridinol hydrochloride (emoxypine) - 0,01 g,
magawo othandizira: madzi a jakisoni - mpaka 1 ml, hydrochloric acid solution (0.1 M) - 0,02 ml.

Mankhwala

Chifukwa cha ntchito yomwe ili gawo la Emoxibel, imachita zinthu zotsatirazi:

zimakhudza bwino dongosolo la kuphatikizika kwa magazi: imakulitsa nthawi ya magazi, imachepetsa chiwonetsero chonse cha kuphatikizika,
kumawonjezera kukana kwa maselo ofiira a m'magazi ku hemolysis ndi kuvulala kwamakina, kumathandizira mawonekedwe am'mitsempha yamagazi ndi maselo ofiira a magazi,
bwino masinthidwe am'manja,
kumawonjezera ntchito ya antioxidant michere, tikulephera ufulu oxidation wa lipids a biomembranes,
ili ndi zotsatira za antitoxic and angioprotective, imakhazikika cytochrome P₄₅₀,
imakweza njira za bioenergy m'malo ovuta kwambiri, limodzi ndi hypoxia ndi kuchuluka kwa lipid peroxidation,
kumawonjezera kukana kwa ubongo kukhala ischemia ndi hypoxia,
kusokonezeka kwa ischemic ndi hemorrhagic kufalitsidwa kwa ubongo kumathandizira ntchito za mnemonic, kumathandizira kubwezeretsanso kwa kuphatikiza kwa ntchito zaubongo, kumathandizira kukonza kwa kusakhazikika kwa malingaliro,
Imachepetsa kuphatikiza kwa triglyceride, ili ndi katundu wotsitsa lipid,
Amachepetsa kuwonongeka kwa myocardium, kumachepetsa ziwiya zamatumbo,
ndi myocardial infarction, zimathandizira kuteteza matenda a myocardial metabolism, imathandizira kukonzanso njira, imachepetsa kukula kwa cholinga cha necrosis,
Pochepetsa kuchulukana kwa mtima pachimake kumakhudza bwino matenda omwe amabwera chifukwa cha kulowerera m'mitsempha,
ndi kulephera kwazungulira kumapereka kayendedwe ka redox system.

Pharmacokinetics

Makhalidwe a methylethylpyridinol hydrochloride (emoxypine):

mayamwidwe: ndi pa / kumayambiriro amakhala ndi nthawi yotsika pang'ono yochotsa (T_½ ndi 18 min, yomwe ikuwonetsa kuchuluka kwachotsedwa pamwazi), kuchotsedwa kosalekeza ndi 0,041 min, kuvomerezeka kwathunthu kwa Cl ndi 214.8 ml pa 1 min,
kugawa: kuchuluka komwe kumagawidwa - 5.2 l, kulowa mkatikati mwa ziwalo ndi minofu ya thupi la munthu, pomwe umayikidwa ndikuwupanga,
kagayidwe: kamakhala ndi ma metabolites 5 omwe amayimitsidwa ndi zotembenuka ndi zopindika za kutembenuka kwake, ma metabolites amathandizidwa ndi impso, 2-ethyl-6-methyl-3-hydroxypyridine-phosphate imapezeka mu chiwindi chambiri.
excretion: pathological zinthu zimachepetsa kuchuluka kwa kutulutsa kwake, komwe kumawonjezera kukhudzika kwake, komanso kumawonjezera nthawi yake yokhala m'magazi (zitha kuphatikizidwa ndi kubwereranso kwake kuchokera ku depot, kuphatikizapo ku ischemic myocardium).

Ma pharmacokinetics a Emoxibel mu momwe zinthu zimasinthira (mwachitsanzo, ndi coronary occlusion).

Njira yothetsera kulowetsedwa, yankho la iv and / m management

nthawi yogwira ntchito odwala omwe ali ndi vuto laubongo, ophatikizidwa ndimatenda am'mimba, amiseche komanso matenda am'mimba ophatikizidwa ndi kuvulala kwa ubongo, kuvulala pamutu ndi kuvulala kwa ubongo, kuperewera kwa mitsempha yoperewera, ngozi yochepa yam'mimba, matenda a hemorrhagic dziwe la mkati mwa carotid artery ndi vertebrobasilar system (gwiritsani ntchito mu neurosurgery ndi neurology),
osakhazikika angina pectoris, kupewa reperfusion syndrome, pachimake myocardial infarction (ntchito zamtima).

Yankho la jakisoni

Kuwotcha, kuvulala, matenda oopsa a ziphuphu,
Mphamvu ya khungu la maso ndi khungu la glaucoma
mawonekedwe owuma a angiosulinotic macular degeneration,
myopathy yovuta
chorioretinal dystrophy (pakati komanso potentha),
angioretinopathy, kuphatikizapo matenda ashuga,
intraocular ndi subconjunctival hemorrhages ochokera kumayendedwe osiyanasiyana,
thrombosis yam'kati mwa mtsempha wa retina ndi nthambi zake,
kupewa ndi kuchiritsa zilonda zam'maso ndi kuwala kozama (ma radiation a laser pa laser coagulation, kuwala kwa dzuwa).

Contraindication

wosakwana zaka 18
Mimba (kupatula jakisoni)
mkaka wa mkaka (kupatula jakisoni)
tsankho limodzi ndi zigawo zikuluzikulu za mankhwala.

Achibale (matenda / mikhalidwe yomwe makonzedwe a Emoxibel amafunikira kusamala):

yankho la mtsempha wamitsempha ndi makonzedwe: kupezeka kwa zizindikiro za magazi kwambiri, maopareshoni, mkodzo wa hemostasis,
jekeseni: pakati, kuyamwa.

Njira yothetsera kudzera mu mtsempha wamitsempha

Emoxibel imayendetsedwa mu / mu kapena / m. Iv isanayambike, yankho lake limapukusidwa mu 200 ml ya dextrose solution ya 5% kapena 0,9% sodium chloride.

Mlingo wa mankhwalawa komanso kutalika kwa mankhwalawa amakhazikitsidwa payekhapayekha.

mitsempha, mitsempha ya m'mitsempha: kukoka kwa mtsempha wa 0,01 g pa 1 makilogalamu a kulemera kwa thupi patsiku pamlingo wa 20-30 akutsikira mu 1 min kwa masiku 10-12, ndiye kuti wodwalayo amapatsidwa jakisoni wamtsempha wa 0,06-0 , 3 g katatu patsiku kwa masiku 20,
mtima: iv kukadontha 0,6-0.9 g katatu patsiku pamiyeso ya 20-25 kutsika mu 1 mphindi kwa masiku 5 mpaka 15 ndikupititsanso wodwala ku / m makonzedwe a 0.06-0 3 g ya mankhwala katatu patsiku kwa masiku 10-30.

Malangizo apadera

Mankhwala a Emoxibel amachitika pansi pa kayendetsedwe kosalekeza ka magazi ndi magazi.

Njira yothetsera kulowetsedwa sikuyenera kusakanikirana ndi mankhwala ena.

Asanakhazikitsidwe madontho amaso, magalasi ofewa ayenera kuchotsedwa. Pambuyo pa mphindi 20 (osati kale), magalasi amatha kuvalanso. Pankhani ya kuphatikiza mankhwala ndi madontho ena ammaso, Emoxibel adakhazikika komaliza, mphindi 15 (osati kale) atatha kumwa mankhwala kale.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kumayambiriro kwa kugwiritsa ntchito yankho la kulowetsedwa, komanso odwala omwe akuwona kugona kapena kuchepa kwa kuthamanga kwa magazi atagwiritsa ntchito yankho la iv ndi / m kayendetsedwe kapena jakisoni, muyenera kukana kuyendetsa magalimoto ndikuchita zochitika zowopsa.

Kupanga ndi mawonekedwe a kumasulidwa

Emoxibel yankho la mtsempha wa magazi ndi makina - amadzimadzi alibe utoto kapena utoto pang'ono mu 5 ml ampoules, muli:

Mphamvu yogwira: emoxypine (methylethylpyridinol hydrochloride) - 30 g,
Zowonjezera: sodium hydrogen phosphate dodecahydrate, sodium sulfite, madzi.

Zonyamula ma cell 1 kapena 2 ma PC. Ma ampoules 5 a katoni. Malangizo, operewera.

Fomu ya Mlingo:

Kufotokozera:
choyera, chopanda khungu kapena chamtundu pang'ono.

Kupanga
1 lita: ntchito: methylethylpyridinol hydrochloride (emoxypine) - 30 g,
zokopa: sodium sulfite, sodium hydrogen phosphate dodecahydrate, madzi a jakisoni.

Gulu la Pharmacotherapeutic:

Code: C05CX

Zotsatira za pharmacological.
Ndi zoletsa za njira zosinthika zaulere, antihypoxant ndi antioxidant. Imachepetsa kukhudzika kwa magazi ndi kuphatikiza kwa ma cell, kuonjezera zomwe zili mu cyclic nucleotides (cAMP ndi cGMP) m'mapulateleti ndi ubongo, imakhala ndi ntchito ya fibrinolytic, imachepetsa kutsimikiza kwa khoma la mtima komanso chiopsezo cha kukha mwazi, imalimbikitsa kuyambiranso. Amakulitsa ziwiya zama coronary, munthawi yovuta kwambiri ya infrction ya myocardial imachepetsa kukula kwa kuyang'ana kwa necrosis, imapangitsa mgwirizano wamtima ndi ntchito yamayendedwe ake. Ndi kuthamanga kwa magazi (BP) kumakhala ndi vuto lothetsa nzeru. Mu pachimake ischemic matenda a kufala kwa magazi kumachepetsa kukula kwa minyewa, kumawonjezera minyewa kukana hypoxia ndi ischemia.

Pharmacokinetics
Mukaperekedwa kudzera m'mitsempha ya 10 mg / kg, theka la moyo ndi 0,3 maola, chilolezo chonse cha CL ndi 0,2 l / min, kuchuluka komwe kumagawidwa ndi 5.2 l. Mankhwalawo amalowa mwachangu ziwalo ndi minyewa, pomwe imayikiridwa ndikuwupangika. Ma metabolites asanu a methylethylpyridinol, omwe amayimilidwa ndi desalkylated ndi conjugated product of kutembenuka kwake, adapezeka. Methyl ethyl pyridinol metabolites amathandizidwa ndi impso. Mitundu yayikulu ya 2-ethyl-6-methyl-3-hydroxypyridine-phosphate imapezeka m'chiwindi. Ndi matenda a mtima, bioavailability imachulukirachulukira.

Zizindikiro zogwiritsidwa ntchito.
Monga gawo la mankhwala:

Mu neurology ndi neurosurgery: hemorrhagic stroke pakubwezeretsa, ischemic stroke mu beseni la carotid artery and vertebrobasillar system, kuchepa kwa vuto la mtima, kuchepa kwa vuto la kuchepa kwa magazi, kuvulala kwa ubongo, nthawi yothandizidwa ndi odwala ovulala ndi ubongo, opera za epi-, subdural and intracerebral hematomas, wophatikizidwa ndi mikwingwirima ya ubongo.

Mu mtima: pachimake myocardial infarction, kupewa reperfusion syndrome, osakhazikika angina pectoris.

Contraindication
Hypersensitivity, kutenga pakati, kuyamwa, msambo wa ana.

Ndi chisamaliro: odwala omwe ali ndi vuto la kuchepa kwa magazi, pa nthawi ya opaleshoni kapena odwala omwe ali ndi vuto lotaya magazi kwambiri (chifukwa cha kuchuluka kwa kuphatikiza kwa ziwalo zam'magazi).

Mlingo ndi makonzedwe.
Mothandizidwa ndi mitsempha kapena kudzera m'mitsempha.
Mlingo, nthawi ya mankhwala anatsimikiza payekha. Pakukonzekera kwa mtsempha wa mankhwalawa, mankhwalawa amathandizira kale mu 200 ml ya 0,9% sodium kolorayidi kapena 5% dextrose solution.
Mu neurology ndi neurosurgery: kudzera mu mtsempha wa magazi, 20-30 mg / tsiku kwa mphindi 10 mg / tsiku kwa masiku 10-12, ndiye kuti amasinthana ndi jakisoni wa 60 mg wa 200 mg kawiri pa tsiku kwa masiku 20.
Mu mtima: kudzera mu mtsempha wa magazi, akutsikira mtsempha wa madzi 20 mg pamphindi muyezo wa 600-900 mg katatu pa tsiku kwa masiku 5 mpaka 5, kenako ndi jakisoni wa 60 mg wa 2-3 kawiri pa tsiku kwa masiku 10-30 .

Zotsatira zoyipa.
Ndi mtsempha wamkati, kumverera koyaka ndi kupweteka m'mitsempha ndikotheka, pakhoza kukhala kuwonjezeka kwa kuthamanga kwa magazi, kukwiya kapena kugona, kuphwanya magazi. Nthawi zina, kupweteka mutu, kupweteka m'dera la mtima, nseru, kusokonekera kwa epigastric dera, kuyabwa ndi redness khungu ndizotheka.

Kuchita ndi mankhwala ena.
Methyl ethyl pyridinol imagwirizana mosiyanasiyana ndi mankhwala ena, chifukwa chake kusakaniza mu syringe yomweyo kapena infusomat ndi mankhwala ena opakidwa sikuloledwa.

Bongo
Zizindikiro kuchuluka kwa zotsatira za mankhwalawa (kupezeka kwa kugona ndi kusinza), kuchuluka kwakanthawi kothamanga kwa magazi.
Chithandizo: Zizindikiro, kuphatikiza Kukhazikitsidwa kwa mankhwala a antihypertensive omwe amayang'aniridwa ndi kuthamanga kwa magazi. Palibe mankhwala enieni.

Malangizo apadera.
Kuchiza ndi Emoxibel, pakukonzekera kwake kwamkati ndi mu mnofu, kuyenera kuchitika motsogozedwa ndi kuthamanga kwa magazi ndi magwiridwe antchito a magazi a coagulation ndi anticoagulation.
Anthu omwe amalengeza kugona kapena kuchepa kwa magazi atagwiritsa ntchito Emoxibel ayenera kukana kuyendetsa galimoto ndi makina oopsa.

Kutulutsa Fomu.
Yothetsera kudzera mu mtsempha wa magazi makonzedwe a 30 mg / ml. 5 ml mu ampoules.
Ma ampoules asanu amayikidwa mu ma blout strip ma CD opangidwa ndi filimu ya polyvinyl chloride ndi zojambulazo za aluminiyumu zosindikizidwa kapena pepala lazitsulo kapena pepala lonyamula ndi polinga.
1 kapena 2 chithuza chamtundu limodzi ndi malangizo ogwiritsira ntchito ndi ampulifera ochepa amaikidwa mu paketi a makatoni. Mukamagwiritsa ntchito ma ampoules okhala ndi mphete yong'ambika, ma ampoules amatha kupakidwa popanda zoperewera pang'ono.

Malo osungira.
Pamalo amdima pakutentha kosaposa 25 C.
Pewani kufikira ana.

Tsiku lotha ntchito
Zaka 2
Osagwiritsa ntchito tsiku lanu litatha.

Malo opumulira ochokera ku malo ogulitsa mankhwala.
Amamasulidwa pa mankhwala.

Zodandaula za opanga / ogula ziyenera kuyang'aniridwa.
RUE "Belmedpreparaty", Republic of Belarus, 220007, Minsk, 30 Fabritsius str.

Zotsatira za pharmacological

Mankhwalawa ndi antihypoxant, antioxidant komanso choletsa ufulu wosintha njira. Imatha kuchepetsa kukhuthala kwa magazi, komanso kuphatikiza kwa ma protein, kuonjezera zomwe zili ma cyclic nucleotides (cGMP, cAMP) m'mapulateleti komanso zimakhala. Kuphatikiza apo, imakhala ndi ntchito ya fibrinolytic, imachepetsa kupezeka kwa makhoma amitsempha yamagazi, potero imachepetsa chiopsezo chotaya magazi, komanso imathandizira kuti ayambe kugwiranso ntchito mwachangu.

Emoxibel ali ndi retinoprotective katundu, amasintha ma cellcirculation amaso, amateteza retina ku zotsatira zoyipa za kuwala kwambiri.

Zizindikiro zogwiritsidwa ntchito

Subconjunctival kapena intraocular hemorrhage.
Angioretinopathy, choryoretinal dystrophy.
Retinal mtima wa mtima.
Dystrophic keratitis.
Mavuto a myopia.
Kuteteza cornea ndi diso la diso kuti lisawonongeke ndi kuwala.
Kutentha, kuvulala, kutupa kwa ziphuphu.
Mphaka
Opaleshoni ya maso ndi machitidwe atachitidwa opaleshoni ya glaucoma, yovuta chifukwa cha kuyamwa kwa choroid.

Mlingo ndi makonzedwe

Amalemba subconjunctival / parabulbar, kamodzi tsiku lililonse kapena tsiku lililonse.

Kwa jakisoni wothandizirana, makonzedwe a 0,2-0,5 ml ya yankho la 1% ya mankhwala akulimbikitsidwa, pa parabulbar - 0.5-1 ml. Kutalika kwa nthawi yogwiritsira ntchito ndikuyambira masiku 10 mpaka 30. Kubwereza maphunzirowa kumatheka chaka chilichonse kapena katatu.

Ngati njira yoyendetsedwera kwa botobola ndiyofunika, mlingo wa jakisoni ndi 0.5-1ml wa yankho la 1%, kamodzi tsiku lililonse kwa masiku 10-15.

Pofuna kuteteza retina panthawi ya laser coagulation, parabulbar kapena jakisoni wa pulobulbar wa 0,5-1ml ya 1% yankho limayikidwa, omwe amachitidwa tsiku limodzi ndondomeko isanachitike, komanso ola limodzi asanagundike.Pambuyo pakukula kwa laser, jakisoni amapitilizidwa kumwa kamodzi pamasiku mpaka masiku 10.

Analogs a Emoxibel

Mndandanda wa mankhwala Emoxibel mu ophthalmology ndi mankhwala a Emoxipin.

Kutembenukira ku "Moscow Eye Clinic", mutha kuyesedwa pazida zamakono kwambiri zowunikira, ndipo malinga ndi zotsatira zake - pezani malingaliro anu kuchokera kwa akatswiri otsogolera pakuthandizira matenda omwe adadziwika.

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Mitengo mumaofesi a mankhwala ku Moscow

Zomwe zimaperekedwa pamitengo yamankhwala si kupatsa kapena kugulitsa zinthu.
Zambiri zimangoyeneranso kufananitsa mitengo m'magalimoto apamtundu wogwira ntchito mogwirizana ndi Article 55 ya Federal Law "On the Circulation of Medicines" ya 12.04.2010 N 61-ФЗ.