Protafan NM Penfill - malangizo * agwiritsidwe ntchito

Kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml

1 ml ya kuyimitsidwa kuli

ntchito yogwira - genetic engineering human insulin (insulin-isophan) 100 IU (3.5 mg),

zokopa: protamine sulfate, zinc, glycerin, metacresol, phenol, sodium hydrogen phosphate dihydrate, 2 M sodium hydroxide, 2 M hydrochloric acid, madzi a jekeseni.

Kuyimitsidwa koyera, komwe, kuyimilira, kumakhala exxpatant yowoneka bwino, yopanda utoto kapena mawonekedwe oyera. Mtengo umasinthidwa mosavuta ndikugwedezeka modekha.

Mankhwala

Pharmacokinetics

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo wa insulin, njira ndi malo oyendetsera, makulidwe a subcutaneous mafuta wosanjikiza ndi mtundu wa matenda osokoneza bongo). Chifukwa chake, magawo a pharmacokinetic a insulin ali ndi kusinthasintha kwakukulu kwapakati pa intaneti ndi munthu payekha.

The pazipita ndende (Cmax) wa insulin mu madzi am`magazi amafikira mkati 2-18 maola pambuyo subcutaneous makonzedwe.

Palibe zomangamanga zomanga mapuloteni a plasma zimadziwika, kupatulapo ma antibodies a insulin (ngati alipo).

Insulin yaumunthu imapukusidwa ndi zochita za insulin proteinase kapena ma enzyme okhala ndi insulini, ndipo mwina mwa mapuloteni omwe amachititsa kuti mapuloteni azikhala asomerase. Amaganiziridwa kuti mu molekyulu ya insulin ya anthu pali malo angapo a cleavage (hydrolysis), komabe, palibe amodzi a metabolites omwe amapangidwa chifukwa cha cleavage akugwira ntchito.

Hafu ya moyo (T½) imatsimikiziridwa ndi kuchuluka kwa kuyamwa kuchokera kuzinthu zowoneka bwino. Chifukwa chake, T½ ili ndi gawo lina la mayamwidwe, m'malo mochulukitsa kwenikweni kwa insulini kuchokera ku plasma (T½ ya insulin m'magazi ndi mphindi zochepa chabe). Kafukufuku awonetsa kuti T½ ili pafupifupi maola 5-10.

Mankhwala

Protafan® NM ndi insulin yakumunthu yomwe imagwira ntchito pakapangidwe kamapangidwe amtundu wa DNA pogwiritsa ntchito mtundu wa Saccharomyces cerevisiae. Kutsika kwa glucose m'magazi kumachitika chifukwa cha kuwonjezereka kwa mayendedwe ake amkati atatha kumangiriza insulini kupita ku insulin zolandila minofu ndi adipose minofu ndikuchepa kwamtundu womwewo kwa shuga.

Kugwiritsa ntchito kwa mankhwalawa kumayamba pakangotha ​​maola 1 after pambuyo pakukonzekera, kuchuluka kwake kumawonekera mkati mwa maola 4-12, pomwe nthawi yonse ya kuchitapo kanthu ili pafupifupi maola 24.

Mlingo ndi makonzedwe

Mankhwala anaupanga subcutaneous makonzedwe. Kuyimitsidwa kwa insulini sikungaperekedwe kudzera m'mitsempha.

Protafan ® NM ikhoza kugwiritsidwa ntchito limodzi mu monotherapy komanso kuphatikiza ndi insulin yofulumira kapena yochepa.

Mlingo wa mankhwalawa amasankhidwa payekha, poganizira zosowa za wodwala. Nthawi zambiri, zofunika za insulin zimakhala pakati pa 0.3 ndi 1 IU / kg / tsiku. Kufunika kwa insulin tsiku lililonse kumatha kukhala kwabwino kwambiri kwa odwala omwe ali ndi insulin kukaniza (mwachitsanzo, nthawi yakutha msinkhu, komanso odwala omwe ali ndi kunenepa kwambiri), komanso kutsika mwa odwala omwe ali ndi zotsalira za insulin.

Protafan ® HM nthawi zambiri imayendetsedwa mosadukiza m'malo a ntchafu. Ngati izi ndizotheka, ndiye kuti jakisoni amathanso kuchitika khoma lakumbuyo kwamkati, m'chigawo cha gluteal kapena dera la minofu ya m'mapewa. Ndi kukhazikitsidwa kwa mankhwalawa mu ntchafu, pali kuyamwa pang'onopang'ono kuposa komwe kumayambitsidwa m'malo ena. Ngati jakisoniyo wapangidwira pakhungu lalitali, ndiye kuti chiwopsezo cha mankhwalawa mwangozi amachepetsa.

Singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera, omwe amatsimikizira mlingo wokwanira. Ndikofunikira nthawi zonse kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Protafan® HM mu mbale imatha kugwiritsidwa ntchito limodzi ndi ma insulin, pomwe muyeso umayikidwa, womwe umalola kuyeza muyeso wa insulin m'magawo a ntchito.

Malangizo ogwiritsira ntchito Protafan® NM kuti apatsidwe wodwala.

Musagwiritse ntchito Protafan® NM:

M'mapampu a insulin.

Ngati pali ziwopsezo (hypersensitivity) kwa insulin yaumunthu kapena chilichonse chomwe chimapanga mankhwala a Protafan® NM.

Ngati hypoglycemia imayamba (shuga m'magazi).

Ngati insulin sinasungidwe bwino, kapena ngati yauma

Ngati kapu yodzitchinjiriza ikusowa kapena yatayidwa. Bokosi lirilonse limakhala ndi kapu pulasitiki yoteteza.

Ngati insulin singakhale yoyera komanso yamtambo mutasakaniza.

Musanagwiritse ntchito Protafan® NM:

Chongani cholembera kuti muwonetsetse kuti mukugwiritsa ntchito mtundu woyenera wa insulin.

Chotsani chophimba.

Momwe mungagwiritsire ntchito mankhwala Protafan® NM

Mankhwala a Protafan® NM adakonzedwa kuti azigwiritsa ntchito poyambira. Musamapereke insulin kapena kudzera m'mitsempha. Nthawi zonse sinthani malo opangira jakisoni mkati mwa anatomical dera kuti muchepetse chiwopsezo cha zisindikizo ndi zilonda pamalowa. Malo abwino oti jakisoni ndi: matako, ntchafu kapena phewa.

Momwe mungayendetsere Protafan® NM ngati Protafan® NM yokha imayendetsedwa kapena ngati Protafan® NM isakanikirana ndi insulin yochepa

Onetsetsani kuti mukugwiritsa ntchito syringe wa insulin pomwe muyeso umagwiritsidwa ntchito poyesa kuchuluka kwa zochita.

Jambulani mpweya mu syringe muyezo wogwirizana ndi insulin yomwe mukufuna.

Mukangomwa kumwa mankhwalawo, gubuduzani pakati pa manja anu mpaka insuliniyo ikhale yoyera komanso yamitambo. Kupatsanso mphamvu kumathandizidwa ngati mankhwalawo ali ndi kutentha kwa chipinda.

Lowani insulin pansi pa khungu.

Gwirani singano pansi pakhungu kwa mphindi zosachepera 6 kuti muwonetsetse kuti mulingo wa insulin umayendetsedwa kwathunthu.

Matenda okhala ndi vuto limodzi, makamaka opatsirana komanso kutentha thupi, nthawi zambiri amalimbikitsa kufunika kwa insulin. Kusintha kwa magazi kungafunikenso ngati wodwala ali ndi matenda a impso, chiwindi, mkhutu wa adrenal ntchito, pituitary kapena chithokomiro cha chithokomiro.

Kufunika kosinthidwa kwa mlingo kumatha kuonekanso posintha zolimbitsa thupi kapena zakudya zomwe wodwala amadya. Kusintha kwa Mlingo kungafunike posamutsa wodwala kuchokera ku mtundu wina wa insulin kupita ku ina.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimakhudzidwa ndi odwala omwe amathandizidwa ndi Protafan® NM anali odalira kwenikweni pamankhwala ndipo chifukwa cha pharmacological zochita za insulin.

Izi ndi malingaliro a pafupipafupi pazomwe zimachitika pazochitika zamankhwala, zomwe zimawerengedwa kuti zimakhudzana ndi kugwiritsa ntchito mankhwala a Protafan® NM. Pafupipafupi pamakhala zotsimikiza motere: pafupipafupi (≥1 / 1,000 kuti

Zoyipa:

Mimba komanso kuyamwa
Palibe choletsa kugwiritsa ntchito insulin panthawi yapakati, popeza insulin siyidutsa chotchinga. Kuphatikiza apo, ngati simumachiza matenda ashuga pakatha nthawi, zimayambitsa: chiwopsezo kwa mwana wosabadwayo. Chifukwa chake, chithandizo cha matenda ashuga chiyenera kupitilizidwa pa nthawi yomwe muli ndi pakati.
Onse hypoglycemia ndi hyperglycemia, omwe amatha kukhala ndi vuto losagwiritsidwa ntchito mosiyanasiyana, kumakulitsa chiopsezo cha kusokonezeka kwa fetal ndi kufa kwa fetal. Amayi oyembekezera omwe ali ndi matenda ashuga amayenera kuyang'aniridwa panthawi yonse yomwe ali ndi pakati, ayenera kuti amawongolera kuchuluka kwa shuga wamagazi, malingaliro omwewo amagwiranso ntchito kwa amayi omwe akukonzekera kutenga pakati.
Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu.
Pambuyo pa kubala, kufunikira kwa insulin kumabwereranso msanga momwe zidadziwikira mwana asanabadwe.
Palibenso zoletsa kugwiritsa ntchito mankhwalawa Protafan NM panthawi yoyamwa. Mankhwala a insulin kwa amayi oyamwitsa si owopsa kwa mwana. Komabe, mai angafunike kusintha njira ya mankhwala Protafan NM ndi / kapena zakudya.

Zotsatira zoyipa:

Osowa kwambiri - anaphylactic reaction.
Zizindikiro za hypersensitivity yotchuka ikhoza kuphatikizira zotupa pakhungu, kuyabwa, thukuta, kusokonezeka kwa m'mimba thirakiti, angioedema, kupuma movutikira, palpitations, kutsika magazi, kukomoka / kukomoka.
Maganizo achilengedwe oopsa amatha kukhala pangozi pamoyo.

Kusokonezeka kwamanjenje
Nthawi zambiri zotumphukira neuropathy.
Ngati kusintha kwa kayendedwe ka shuga m'magazi kwakwaniritsidwa mwachangu kwambiri, vuto lotchedwa "ululu wammbuyo" limatha kukhala lomwe limasinthiratu,

Kuphwanya gawo la masomphenyawo
Osowa kwambiri - zolakwika zoyeserera.
Kukonzanso kwina komwe kumachitika kawirikawiri kumadziwika pazigawo zoyambirira za insulin.
Monga lamulo, Zizindikirozi ndizosintha.

Nthawi zambiri - matenda ashuga retinopathy.
Ngati chiwongolero chokwanira cha glycemic chimaperekedwa kwa nthawi yayitali, chiwopsezo cha kupitirira kwa matenda ashuga amachepetsa. Komabe, kukulitsa kwa insulin mankhwala osinthika kwambiri pakulamulira kwa glycemic kungayambitse kuwonjezeka kwakanthawi kwa zovuta za matenda ashuga a retinopathy.

Kusokonezeka kwa khungu ndi minofu yolowerera
Nthawi zambiri - lipodystrophy.
Lipodystrophy imatha kukhazikika pamalo a jekeseni pomwe sipangasinthe malo a jekeseni omwewo m'dera limodzi la thupi.

Kusokonezeka kwa thupi lonse, komanso zimachitika pakubaya
Nthawi zambiri - zimachitika malo jakisoni.
Poyerekeza ndi maziko a mankhwala a insulin, zimachitika pakhungu jekeseni (redness of the khungu, kutupa, kuyabwa, kupweteka, mapangidwe a hematoma pamalo a jekeseni). Komabe, nthawi zambiri, izi zimachitika mosadukiza ndipo zimatha mwanjira yopitilira chithandizo.

Nthawi zambiri - kudzisunga.
Kutupa kumadziwika nthawi yoyamba ya insulin. Monga lamulo, chizindikiro ichi chimakhala chachilengedwe.