The kapangidwe ndi mtengo wa mankhwala "Liraglutid" mu malangizo ntchito, analogues, ndemanga

Mankhwala "Liraglutide" afalikira ku America pansi pa dzina la "Victoza." Yakhala ikugwiritsidwa ntchito kuyambira 2009 pochiza odwala matenda ashuga omwe ali ndi mtundu wa 2 matenda. Ichi ndi mankhwala a hypoglycemic, obayidwa nawo. USA, Russia ndi mayiko ena angapo ali ndi chilolezo chogwiritsa ntchito. Mankhwalawa amatha kukhala ndi mayina osiyanasiyana kutengera dziko lakelo. "Liraglutide" itha kugwiritsidwanso ntchito pochiza kunenepa kwambiri kwa akuluakulu.

Mankhwalawa amapezeka mwanjira yankho lomveka bwino. Amawonetsedwa poyendetsa zinthu mosadukiza. Chofunikira chachikulu ndi liraglutide. Zophatikizidwanso monga zina zowonjezera muzolemba:

• propylene glycol
• hydrochloric acid
• phenol
• madzi
• sodium hydrogen phosphate.

Kuphatikizika uku ndikoyenera kwambiri pochita zomwe zalengezedwa ndi opanga. Zomwe zimagwira ndi chithunzi cha peptide yamunthu. Gawo lake limakulitsa kupanga kwa insulin m'maselo a beta. Chifukwa chake, minofu ya adipose ndi minofu imayamba kuyamwa glucose mwachangu, ndikugawika m'maselo, kuchepetsa kuchepa kwake m'magazi. Ndikupezeka kuti mankhwalawa ndi hypoglycemic. Ndiwothandiza kwambiri, malinga ndi kufotokozerako kumadziwika ndi kuchitapo kanthu kwanthawi yayitali. Ikaperekedwa kamodzi patsiku, imasungabe zotsatira zake masana.

Kutulutsa Fomu

Mankhwalawa amapezeka pamapiritsi ndi njira zothetsera mavuto. Pambuyo polowa m'thupi, nthawi yomweyo imalimbikitsa kupanga insulin. Enzyms amapangidwa mwachilengedwe. Jakisoni amagwira ntchito mwachangu poyerekeza ndi mapiritsi. Pankhani imeneyi, madokotala amakupangira jakisoni wogwiritsidwa ntchito ngati mankhwala a kunenepa kwambiri. "Liraglutide" wa jakisoni amapezeka mu cholembera chapadera ndi singano. 1 ml yankho lili ndi 6 mg ya yogwira pophika.

Mu bokosi la makatoni okhala ndi malangizo amabwera 1, 2 kapena 3 syringes. Yankho limodzi limakwanira jakisoni 10, 15 kapena 30. Amapangidwa pansi pa khungu - paphewa, pamimba kapena ntchafu. Ndi zoletsedwa mwamphamvu kuyambitsa minofu kapena mtsempha.

Ngati simukuphwanya kulimba kwa phukusi, ndiye kuti moyo wa alumali ndi miyezi 30. Cholembera chimasungidwa patatha mwezi umodzi jakisoni woyamba, yankho lotseguka liyenera kuyikidwa mufiriji pa madigiri 2 - 8. Ndi zoletsedwa kuti ziwundane, apo ayi yankho limakhala losagwira.

Pharmacodynamics ndi pharmacokinetics

Mankhwalawa ndi othandizira odwala matenda ashuga, amathandizanso kuchepetsa kulemera. Kunenepa kwambiri nthawi zambiri kumayambira odwala matenda ashuga amtundu 2.

Mukalowa m'magazi a wodwalayo, mankhwalawa kangapo amakulitsa kuchuluka kwa ma peptides, omwe amakupatsani mphamvu zachilengedwe ndikupanga ma insulin. Zidakwaniritsidwa kuti kuchuluka kwa shuga m'magazi kumayamba kutsika kukhala bwino. Komanso, zinthu zonse zopindulitsa zomwe zimalowa m'thupi ndi chakudya zimamwa bwino. Zikuwoneka kuti kulemera kwamunthuyo ndikwabwino, njala imachepetsedwa.

Kumwa mankhwalawa ndikololedwa mosamalitsa monga momwe dokotala amafotokozera. Simuyenera kuyambitsa ntchito yanu kuti muthane ndi kunenepa kwambiri. Imakhala chisankho chabwino kwambiri kwa odwala matenda ashuga, omwe adalimbikitsa kuchuluka kwambiri.

"Liraglutide" itha kutumikiridwa kuti ichititse kuchuluka kwa glycemia. The mayamwidwe yogwira mankhwala pa subcutaneous jakisoni pang'onopang'ono, ndipo nthawi yofika kwambiri ndende ukufika 12 mawola kukhazikitsa.

Zizindikiro ndi contraindication

Kwa kuwonda "Liraglutid" amaloledwa pokhapokha akutsimikizira katswiri. Nthawi zambiri amawonetsedwa kwa odwala omwe ali ndi matenda a shuga a 2, malinga ndi momwe vutoli silinapezeke pambuyo pakuthanso kwa zakudya komanso moyo. Mankhwalawa amathandizira kubwezeretsa chindoko cha glycemic chifukwa chophwanya.

Contraindication kuti agwiritse ntchito akuphatikizapo:

• mtundu 1 shuga
• Hypersensitivity pazigawo,
• kwambiri matenda a chiwindi kapena impso,
• kulephera kwa mtima 3, 4 madigiri,
• kutupa m'matumbo
• chotupa mu chithokomiro
• mkaka wa m'mimba, pakati.

Sichikupatulidwa, koma nthawi zambiri sizikulimbikitsidwa kuti zigwiritsidwe ntchito m'malo otere:

• nthawi yomweyo kubayira insulin,
• anthu opitilira 75
• odwala ndi kapamba.

Mosamala, adotolo adalemba "Liraglutid" wamatenda amtima. Zokhudza ndi momwe mankhwalawo amathandizira pakukhazikitsa njira zina zochepetsera thupi sizinakhazikitsidwe. Palibenso chifukwa choyesera, kuyesa njira zosiyanasiyana kuti muchepetse kunenepa. Ana ndi achinyamata ochepera zaka 18 sayenera kugwiritsa ntchito mankhwalawa, pokhapokha, ndi dokotala yekha amene amamuwuza atazindikira bwino matendawo.

Zotsatira zoyipa

Mutazolowera malangizo a mankhwalawa, zimadziwika kuti musanayambe chithandizo ndi mankhwalawa, muyenera kudziwa ngati zingavulaze kwambiri thanzi lanu.

Kuyipa kodziwika komwe kumachitika pamapiritsi kapena kuthana ndi vuto logaya m'mimba. Mu 50% ya milandu yoyipa, nseru yayikulu, kusanza kumachitika.

Aliyense wachisanu wodwala matenda ashuga ndi chithandizo"Liraglutidom" imadandaula za mavuto pantchito yam'mimba - nthawi zambiri imakhala yotaya kwambiri kapena kudzimbidwa.

Zina zoyipa zimaphatikizira kutopa kwakuthupi, kutopa msanga.

Nthawi zina mukamwa mankhwala okwanira, shuga m'magazi amatsika kwambiri. Panthawi imeneyi, supuni ya uchi imathandizira wodwalayo kumva mwachangu.

Mlingo ndi bongo

Jakisoni amatha kutumikiridwa pang'onopang'ono m'mimba, phewa kapena ntchafu. Ndikulimbikitsidwa kuti muzisinthasintha malo obayira jekeseni kuti musayambitse lipodystrophy. Kuphatikiza apo, lamulo la jakisoni ndikuyambitsa nthawi yomweyo ya tsiku. Mlingo umasankhidwa payekha ndi katswiri.

Mankhwalawa nthawi zambiri amayamba ndi 0,6 mg kamodzi patsiku. Pakufunika, mlingo ukuwonjezeka mpaka 1.2 mg ngakhale 1,8 mg. Voliyumu ya jakisoni sayenera kukwezedwa pamwamba pa 1.8 mg. Kuphatikiza apo, adotolo atha kukulemberani Metformin kapena mankhwala osokoneza bongo malinga ndi zomwe zimapangidwa ndi dzina lomweli. Popewa hypoglycemia, dokotala amayenera kuwunika mankhwalawo, amatha kusintha malingana ndi mphamvu zake. Kusintha chilichonse palokha nkoletsedwa.

Ngati malamulo ena akukonzekera ndi kugwiritsa ntchito cholembera:

• Nthawi zonse khalani ndi chidwi ndi moyo wa alumali,
• Njira yothetsera vutoli iyenera kukhala yowonekera, popanda mthunzi, mankhwala amtambo ndi oletsedwa kugwiritsa ntchito,
• singano yotayika iyenera kumangika kwambiri ku syringe,
• Bokosi lakunja la syrolo limasungidwa, mkati mwake amatayika.
• singano yatsopano imafunikira singano yatsopano kuteteza kumatenda kapena kufalikira,
• ngati singano yakunga, yowonongeka, nkoletsedwa kugwiritsa ntchito.

Ndi mankhwala osokoneza bongo, chithunzi chotsatira chachipatala chimayamba:

• nseru, kufooka, ndi kusanza
• kusowa kwa chakudya
• kubwatula
• kutsegula m'mimba

Hypoglycemia sichimakula, bola ngati nthawi yomweyo wodwalayo sanamwe mankhwala ochepetsa thupi.

Malinga ndi malangizo, ngati mankhwala osokoneza bongo, kusanza kuti amasule zam'mimba mankhwala otsalira a mankhwala ndi metabolites. Pachifukwa ichi, ma ufiti amafunikira, ndiye kuti chithandizo chamankhwala chimakwaniritsidwa. Zotsatira zakuchulukitsa za mankhwalawa zimatha kupewedwa ngati chiwembu chosankhidwa chikutsatiridwa mosamalitsa. Wopangidwa ndi dokotala, amawongolera njirayi ndi zotsatira zake.

Kuchita

Popanga kafukufuku wa zamankhwala, "Liraglutide" adawonetsa kuchepa kwa magwiridwe antchito a mankhwala.

Mukamagwiritsa ntchito mankhwalawa, kuchepa m'matumbo kungayambike, komwe kumakhudza mayamwidwe a mankhwalawa amkamwa. Koma zoterezi siziyenera kuonedwa kuti ndizofunika kwambiri m'thupi. Vuto limodzi la matenda otsegula m'mimba silimawoneka kawirikawiri ndi zomwe zimagwiritsidwa ntchito pakamwa pa aliyense pakamwa.

Mankhwalawa ali ndi mitundu yambiri komanso mitundu yambiri.

Ndi dokotala wokhayo amene angadziwe kufunika kosinthira ndi ma analogues, kuyenerera kwawo kogwiritsira ntchito kuwonda. Sikoyenera kuchita mankhwala omwe mumakhala nokha, chifukwa zimatha kubweretsa zotsatira zoyipa ndikuwonongeka pakupanga ndalama.

Patatha mwezi umodzi ndikugwiritsa ntchito mankhwalawa, shuga adayamba kukhazikika, ngakhale zinali zovuta kwambiri kuti zizindikiritso zisanachitike. Kuphatikiza apo, ndinatsatira malamulo onse omwe adotolo adakhazikitsa - chakudya. Tiyeneranso kudziwa kuti pakhala pali kupweteka kwakumapeto kwa kapamba.

Valentina, wazaka 45

Ndimatenga "Liraglutide" kwa miyezi itatu, palibe mavuto omwe adachitika. M'masiku ochepa oyambira, nseru pang'ono ndi mutu wochepa zimawonekera. Kuphatikiza pa zotsatirapo za hypoglycemic, ndachepa thupi, chilakolako cha chakudya sichinali chachikulu.

Jakisoni "Liraglutid" atha kuthana ndi vuto la shuga. Chofunikira kwambiri ndikuwunika moyo wa alumali komanso kutsimikizika kwa mankhwalawo musanagule. Muyenera kugula malinga ndi zomwe dokotala wakupatsani mu pharmacy yokha.

Mtengo wake umatengera muyeso wa mankhwala othandizira:

• yankho la jakisoni 6 mg mu 1 ml - kuchokera ku ma ruble 10,000.
• cholembera syringe 18 mg pa 3 ml ya yankho - kuchokera 9,000 ma ruble.

Pomaliza

Madotolo agogomezera kuti kwa wodwala aliyense amafunika kusankha payekha mankhwala a Liraglutid ”. Izi zimathandiza kuthetseratu mavuto olemetsa, kuchulukitsa msanga shuga. Pazifukwa izi, kugwiritsa ntchito mankhwala amaloledwa pokhapokha kukaonana ndi katswiri.