Diameride analogues
Diamerid (mapiritsi) Kutalika: 37
Wopanga: Akrikhin (Russia)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera ku ma ruble 210
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku 319 rubles
Malangizo ogwiritsira ntchito
Canonpharma (Russia) Glimepiride Canon ndi imodzi mwamankhwala opindulitsa kwambiri pochizira matenda amishuga a 2 omwe amachokera pa glimepiride chimodzimodzi. Amawonetsera kusagwira bwino kwa zakudya komanso zolimbitsa thupi.
Mndandanda wa mankhwala Diamerid
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 99.
Wopanga: Sanofi-Aventis S.p.A. (Italy)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera ku 309 rubles
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 539
Malangizo ogwiritsira ntchito
Amaryl ndimankhwala amtundu wa shuga wachiwiri mwanjira ya mapiritsi ofunikira kugwiritsidwa ntchito kwamkati. Monga yogwira mankhwala, glimepiride imagwiritsidwa ntchito pa 1 mpaka 4 mg. Pali contraindication ndi mavuto.
Analogue ndiotsika mtengo kuchokera ku ma ruble 71.
Wopanga: Berlin-Chemie / Menarini Pharma (Germany)
Kutulutsa Mafomu:
- Mapiritsi a 5 mg, ma PC 58., Mtengo kuchokera ku ma ruble 139
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 539
Malangizo ogwiritsira ntchito
Piritsi yothandizira mankhwalawa matenda a shuga yochokera ku glibenclamide (mu mawonekedwe a micron) mu muyeso wa 1.75 mg. Amawonetsedwa kuti agwiritse ntchito mtundu wa 2 matenda a shuga (ndi kusagwira ntchito mosamalitsa m'thupi).
Analogue ndiyotsika mtengo kuchokera ku ma ruble 24.
Wopanga: Canonpharma (Russia)
Kutulutsa Mafomu:
- Tab. 2 mg, 30 ma PC., Mtengo kuchokera ku 186 rubles
- Tab. 4 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 252
Malangizo ogwiritsira ntchito
Glimepiride Canon ndi imodzi mwamankhwala opindulitsa kwambiri pochiza matenda a shuga 2 omwe amachokera ku glimepiride chimodzimodzi. Amawonetsera kusagwira bwino kwa zakudya komanso zolimbitsa thupi.
Analogue ndiotsika mtengo kuchokera ku ma ruble 91.
Wopanga: Akrikhin (Russia)
Kutulutsa Mafomu:
- Mapiritsi 80 mg, 60 ma PC., Mtengo kuchokera ku ma ruble 119
- Tab. 4 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 252
Malangizo ogwiritsira ntchito
Glidiab ndi amodzi mwamalo opindulitsa kwambiri a gliclazide. Imapezekanso m'mapiritsi, koma mulingo wa DV ndiwambiri apa, womwe uyenera kukumbukiridwa musanayambe chithandizo. Amawonetsera matenda a shuga a 2 omwe samatha kudya komanso kuchita masewera olimbitsa thupi.
Analogue ndiotsika mtengo kuchokera ku ma ruble 81.
Wopanga: Farmakor (Russia)
Kutulutsa Mafomu:
- Mapiritsi 30 mg, 60 ma PC., Mtengo kuchokera 129 ma ruble
- Tab. 4 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 252
Malangizo ogwiritsira ntchito
Akrikhin (Russia) Glidiab ndi amodzi mwamalo opindulitsa kwambiri a gliclazide. Imapezekanso m'mapiritsi, koma mulingo wa DV ndiwambiri apa, womwe uyenera kukumbukiridwa musanayambe chithandizo. Amawonetsera matenda a shuga a 2 omwe samatha kudya komanso kuchita masewera olimbitsa thupi.
Analogue ndiyotsika mtengo kuchokera ku ma ruble 164.
Wopanga: Valenta (Russia)
Kutulutsa Mafomu:
- Mapiritsi a 5 mg, 50 ma PC., Mtengo kuchokera ku ma ruble 46
- Tab. 4 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 252
Malangizo ogwiritsira ntchito
Glibenclamide ndi mankhwala otsika mtengo a ku Russia ochizira matenda ashuga omwe ali ndi zomwe zimapangidwa pakapangidwe. Mlingo umatengera zaka za wodwala komanso kuopsa kwa chithandizo cha matenda ashuga.
Analogue ndiyotsika mtengo kuchokera ku ma ruble 19.
Wopanga: Dzuwa (Russia)
Kutulutsa Mafomu:
- Tab. 2 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 191
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Glimepiride ndi mankhwala apakhomo pochizira matenda amishuga a 2. Amapezeka mu mawonekedwe a mapiritsi okhala ndi zinthu zomwezi mu gawo la 2 mpaka 4 mg pa piritsi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 563.
Wopanga: Kimika Montpellier (Argentina)
Kutulutsa Mafomu:
- Tab. 4 mg, 40 ma PC., Mtengo kuchokera ku ma ruble a 773
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Mankhwalawa ndi wa ku Argentina wochokera pa glimepiride pa mlingo wa 4 mg piritsi limodzi. Amawonetsedwa kuti agwiritse ntchito mtundu wa 2 shuga mellitus (monga monotherapy kapena ngati gawo la mankhwala ophatikiza).
Analogs popanga ndi chisonyezo chogwiritsidwa ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Amaril | 27 rub | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Guwa | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay Glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Wokongola | -- | -- |
| Glimepiride glimepiride | 27 rub | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 rub | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa cholowa m'malo mwa diamerid, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito
Analogs mwa chisonyezo ndi njira yogwiritsira ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Glibenclamide Glibenclamide | 30 rub | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeteson MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 57 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa komanso momwe mungagwiritsire ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Rosiglitazone wothandiza, metformin hydrochloride | -- | -- |
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 rub | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 rub | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 rub | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Fomu metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Forethine | 37 rub | -- |
| Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc | 26 rub | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Metformin-teva metformin | 43 rub | 22 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 rub | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 rub | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 rub | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 rub | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 rub | 895 UAH |
| Onglisa saxagliptin | 1472 rub | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
| Lixumia lixisenatide | -- | 2498 UAH |
| Malo a Guarem Guar | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 rub | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 rub | 3200 UAH |
| Invocana canagliflozin | 13 rub | 3200 UAH |
| Jardins Empagliflozin | 222 rub | 566 UAH |
| Trulicity Dulaglutide | 115 rub | -- |
Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?
Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwiritsidwa ntchito ndikuwonetsa. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.
Kugwiritsa
Aliyense wodwala matenda ashuga, atatha kuchuluka kwa kudya zakudya zamafuta ochepa ndikuchepetsa mphamvu zolimbitsa thupi komanso kuchuluka kwa msinkhu, amadziwa bwino mapiritsi a hypoglycemic. Uwu ndi mndandanda wokwanira wamankhwala omwe amathandizira kuchepetsa shuga la magazi mwa kumwa mapiritsi musanadye. Pali magulu awiri a mankhwala omwe amadziwika ndi odwala matenda ashuga:
- zochokera sulfonylurea,
- khwawa.
Zochita za sulfonylurea zotumphukira zimafotokozedwa osati kokha ndi kuwonjezeka kwa insulin, komanso mwa kusintha kwa chidwi cha zotumphukira zake.
Biguanides amachepetsa kuyamwa kwa shuga m'matumbo ang'onoang'ono, kumathandizira kuyamwa kwake pazowonjezera, kukulitsa chidwi cha maselo kuti apange insulin, yomwe imasinthika ndikugwiritsa ntchito shuga m'minyewa ndi hepatocytes.
Mankhwala a Diameride ndi a m'badwo wachitatu wa anthu a sulfonylurea ndipo amangoikidwa ngati othandizira pakamwa. Amawonetsedwa ngati chithandizo kwa anthu omwe ali ndi metabolic syndrome ndipo, chifukwa chake, a 2 matenda ashuga. Itha kutumikiridwa onse munjira imodzi komanso kuphatikiza ndi mapiritsi ena ochepetsa shuga kapena ndi insulin.
Zomwe zimagwira piritsi la diamerid ndi glimepiride. Amayikidwa pa 1,2,3 ndi 4 mg. Popanga mapiritsi, zinthu monga magnesium stearate, shuga mkaka, povidone, microcrystalline cellulose, sodium craquelade, ndi utoto umagwiritsidwa ntchito.
Kuchuluka kwa shuga m'magazi kumachepetsedwa chifukwa cha mphamvu ya glimepiride kuonjezera kupanga kwa insulin yama cell ndi ma cell a pancreatic ndikuwongolera mayankho awo pakupanga shuga. Poyerekeza Diameride ndi yemwe adayambitsa, Glibenclamide, zitha kuwoneka kuti, pamtengo wotsika, Diameride ali ndi kutsitsa kofanana ndi shuga. Izi zikusonyeza kuti ali ndi extrapancreatic kwenikweni, monga kuwonjezeka kwa ntchito ya insulin yomanga shuga.
Kukhazikitsa kwa insulin katulutsidwe kumalumikizidwa ndi kuchulukana kwa intracellular calcium chifukwa cha membrane depolarization, kumapangitsa kupanga insulin. Mapulogalamu omwe amagwira ntchito ndi mapuloteni amawonetsa maselo apadera a pancreatic kuti achepetse glucose ndikuletsa kutsika kwawo.
Nthawi zambiri, shuga wolowa m'thupi amatengedwa ndi mamolekyu a protein kupita ku minyewa ndi mafuta. Diamerid imachulukitsa kuchuluka kwa mamolekyulu amenewo. Selo limayankha kagayidwe kameneka kamene kamalowa ndikuwonjezereka kwa ntchito ya phospholipase enzyme, chifukwa chomwe glucose zomwe zili mu cell zimatsika nthawi yomweyo ndi kuchepa kwa ntchito ya protein kinase enzyme, yomwe imatsogolera ku activation ya carbohydrate metabolism.
Amadziwika kuti mankhwalawa ali ndi zina zabwino. Amachepetsa kuphatikiza kwa maselo, kukonza magazi mu kama.
Pazovuta za metabolic, momwe zotsatira za metabolidi ya lipid ndizofunikira kwambiri. Mankhwalawa amachepetsa milingo ya lipid, pali umboni wa kuchepa kwa mafuta a cholesterol m'mitsempha yazinyama poyesedwa kuchipatala.
Mphamvu ya antioxidant imafotokozedwa poteteza nembanemba wa lipid wa maselo ku peroxidation.
Pharmacokinetics
Mankhwala okhala ndi bioavailability wambiri. Ngati 4 mg yatengedwa mwadongosolo, ndiye kuti zomwe zili kwambiri m'magazi amitsempha zimachitika ndikutalika kwa maola awiri ndi atatu. The placenta sateteza mwana wosabadwayo kuti asalowe mu mankhwalawa, imadutsanso mkaka wa m'mawere. Cholepheretsa magazi ndi chovuta kulowa.
Mu kama wamitsempha, amalumikizana ndi mamolekyulu a protein, theka la moyo ndi maola 5-8.
Amayikidwira pamlingo waukulu ndi impso mu mawonekedwe a metabolised komanso mochepera pamatumbo.
Chosangalatsa ndichakuti mu impso odwala omwe ali ndi vuto la impso, palibe kuchuluka komwe kumachitika, ndiko kuti, diamerid siziunjikira m'thupi.
Kutulutsa Fomu
Diamerid amapangidwa ndi kampani yaku Russia ya mankhwala Akrikhin.
Mapiritsi otulutsira mafomu. Ali ndi mawonekedwe a cylindrical, chiopsezo chimayikidwa piritsi. Chofunikira chachikulu piritsi limodzi ndi 1 mg, 2 mg, 3 mg kapena 4 mg. Bokosilo lili ndi matuza atatu, lililonse lili ndi mapiritsi 10. Mapiritsi a 1 ndi 3 mg amtundu wa pinki-kirimu, madontho pang'ono a bulauni amaloledwa. Mapiritsi a 2 mg ndi 4 mg, amtundu wachikaso wopepuka wokhala ndi zonona. Mtunduwo umabwera chifukwa cha kuphatikiza utoto osiyanasiyana - iron oxide ofiira kapena wachikasu.
Contraindication
Nthawi zina, mankhwalawa sangathe kutumikiridwa:
- lembani 1 matenda ashuga komanso zovuta za matenda ashuga mwanjira ya ketoacidosis ndi matenda a shuga.
- zochitika zilizonse zomwe zingayambitse hypoglycemia,
- kuchepa kwa maselo oyera,
- matenda a chiwindi
- Kulephera kwa impso ndi kugwiritsa ntchito zida zokuzira impso,
- kunyamula mwana ndi kuyamwitsa, achinyamata ochepera zaka 18,
- lactose tsankho, malabsorption syndrome,
- idiosyncrasy kuti sulfonylureas ndi sulfonamides.
Chisamaliro chikuyenera kuthandizidwa popereka Diamerid kwa odwala omwe, chifukwa cha zina, omwe ali ndi kusintha kwa jakisoni wa insulin. Chitsanzo ndi kuwonongeka kwakukulu ndikuwotcha, kulephera kwamatumbo, kusokonezeka ndi ntchito yomwe ikubwera.
Zotsatira zoyipa
Zotsatira zoyipa zambiri zimalumikizidwa ndi hypoglycemia, ndiko kuti, kuchepa kwa shuga m'munsi mwa malire abwinobwino. Mawonekedwe a dziko lino ndiosiyanasiyana. Izi zitha kukhala mutu kapena chizungulire, mawonekedwe a mseru komanso kusanza.
Kuchokera ku dongosolo lamanjenje, kutopa, kusokonezeka kwa kugona, kuwodzera kwambiri kumawonedwa. Mwadzidzidzi, nkhawa, kusalimbana modzidzimutsa, kuyika chidwi chovuta, komanso kuchepa kwa liwiro la kuyankha kumatha kuonekera. Ena ali ndi vuto lakukhumudwa, malankhulidwe ndi masomphenya. Mwina kuwoneka kugwedezeka, kulanda pakati genesis, paresis a miyendo. Kuzindikira kwamphamvu kumatha kukula kwambiri mpaka kupuma.
Nthawi zambiri, chikhalidwe cha hypoglycemia chimayendera limodzi ndi kufooka, mawonekedwe a kuzizira, thukuta lomata, tachycardia, kuthamanga kwa magazi kumakwera. Wodwala amakhala ndi zowawa zapachifuwa, palpitations, pamakhala kuphwanya kwa mtima.
Thupi lawo siligwirizana limatha kutenga mitundu yambiri kuchokera ming'oma mpaka kukhumudwa kwa anaphylactic.
Bongo
Mankhwala osokoneza bongo amawonetsedwa ndi chikhalidwe cha hypoglycemia.
Odwala omwe adagwiritsa ntchito Diameride amalangizidwa kuti azikhala ndi zidutswa zinayi za shuga pamodzi ndi iwo, zomwe zimafanana ndi 20 g shuga, ayenera kudyedwa nthawi yomweyo zizindikiro zoyambirira za hypoglycemia zikawoneka. Mukhozanso kumwa tiyi wokoma kapena msuzi wa zipatso pamtengo.
Mavuto akulu achipatala amafuna kuti wodwalayo agonekere kuchipatala. Sambani m'mimba, perekani makala oyambitsa kapena mtundu wina wa enterosorbent. Njira yokhazikika ya glucose imalowetsedwa kudzera m'mitsempha, kulowetsedwa kumapitilira ndi 10% shuga.
Pankhani ya mwangozi makonzedwe a mapiritsi a Diamerida ndi ana, pamene shuga ayambitsidwa kuti azichiritsa matenda a hypoglycemia, kuchuluka kwa shuga wamagazi kuyenera kuyang'aniridwa mosamala kuteteza kusintha kwa hypoglycemia kupita ku hyperglycemia. Kuphatikiza pa kuyesedwa kwa shuga wamagazi, muyenera kuwunika pafupipafupi monga chizindikiro cha hemoglobin ya glycated.
Malangizo ogwiritsira ntchito Diamerida amaphatikiza mlingo wa mankhwalawa ndipo amapereka mankhwala osamalidwa koyambirira kwa chithandizo. Mlingo woyamba sayenera kupitilira 1 mg. Mlingowu umasungidwa kwa masabata 1-2 moyang'aniridwa ndi shuga. Monga lamulo, wodwalayo amaphunzitsidwa m'makalasi apadera a odwala matenda ashuga kuti azidziyang'anira okha kuchuluka kwa shuga pogwiritsa ntchito zingwe zoyeserera.
Ngati magazi a wodwala agwera kwambiri ndi 1 mg ya Diameride, izi zikutanthauza kuti kusintha kwa zovuta za metabolism kumatha kuchitika pogwiritsa ntchito kadyedwe komanso kuchita masewera olimbitsa thupi. Izi zimatheka m'magawo oyamba a matendawa.
Mukamamwa mankhwalawa, pakufunika kuwunika pafupipafupi kuchuluka kwa shuga komanso kusintha kwakanthawi kwa diamerid.
Kuyambitsa chithandizo kapena kusintha kuchokera ku mtundu wina wamankhwala kupita ku diamerid tikulimbikitsidwa ndi 1 mg. Ndi osakwanira kwenikweni, mlingo umawonjezeka kamodzi pa masabata 1-2. Ndondomeko ya kuchuluka motere: 2 mg - 3 mg - 4 mg - 6 mg - 8 mg.
Chithandizo chikuchitika mogwirizana ndi adokotala, wodwalayo ayenera kuchenjezedwa za kufunika kotsatira mokwanira nthawi yomwe mumamwa mapiritsi ndi chakudya. Nthawi zambiri, dokotala amalimbikitsa kumwa Diamerid kamodzi patsiku musanadye chakudya chokwanira, nthawi zambiri asanadye chakudya cham'mawa kapena chamasana. Palibe chifukwa chomwe muyenera kunyalanyaza kufunika kwa chakudya mutamwa piritsi.
Kusintha kagayidwe kachakudya nthawi yamankhwala kumafuna kuchepetsa mlingo wa nthawi.
Kuchepetsa magazi kungafunike zotsatirazi:
- Kulemera kwa thupi la wodwala kwasintha, watopa.
- moyo wa wodwalayo wasintha, zolimbitsa thupi zawonjezereka, njira komanso chikhalidwe, komanso zochitika tsiku ndi tsiku zasintha,
- zinthu zina zinawoneka zomwe zimatha kusintha msinkhu wa shuga pamwamba kapena pansi.
Mukasinthira ku Diameride ndi mankhwala ena, omwe atengedwa ngakhale muyezo waukulu, mlingo woyambirira wa Diamerid sayenera kupitirira 1 mg.
Ngati mayi adatenga Diameride asanabadwe, ndiye kuti zimachitika, ndipo makamaka pakubala, mankhwala amathetsedwa, wodwalayo amapatsidwa insulin. Amayi oyamwitsa ali ndi mwayi wosankha kusiya kudya pakudya pa Diamerid, kapena kupitilirabe kuyamwitsa ndi kusintha kwa mankhwala a insulin komanso kusiyidwa kwa Diamerid.
Kusamala kwina kumafunikira poyendetsa magalimoto ndi makina osuntha. Kusamala kumeneku ndikofunikira kwa odwala omwe alibe matendawa kuti akutsikira kapena asadumphe shuga.
Zizindikiro zakuchuluka kwa shuga ndi ludzu, kamwa yowuma, khungu lowuma komanso mucous nembanemba, kukodza pafupipafupi.
Nthawi zina zimakhala zofunikira kupatsa odwala omwe ali ndi chiopsezo cha kuchuluka kwa shuga kuti asinthe mtundu wawo. Ndikofunikira kusamutsa odwala kupita ku ntchito ina popanda zizindikiritso zakutsogolo.
Kuphatikiza ndi mankhwala ena
Nthawi ya matendawa ingafune kugwirizanitsidwa ndi biguanides kapena insulin.
Pali lamulo lophatikiza. Ngati wodwala alandira kuchuluka kwathunthu kwa Diamerid kapena Metformin, ndiye kuti mlingowu sunasinthidwe, ndipo mlingo wowonjezera wa Metformin kapena Diamerid umayamba ndi mlingo wochepetsetsa woyang'aniridwa ndi dokotala.
Kuphatikiza insulin kuti mupeze mankhwala ndi Diameride, yambani ndi milingo yaying'ono. Momwemonso, mosiyana ndi izi, mukalowa insulin, Diameride imapangidwanso 1 mg.
Tiyenera kudziwa kuti odwala matenda ashuga okalamba komanso odwala omwe amatenga beta-blockers, ziwonetsero zakunja za kutsika kwa shuga m'magazi zimasokonekera, ndipo izi zimabweretsa chiwopsezo cha wodwala wa chikomokere mwadzidzidzi.
Munthawi ya chithandizo ndi Diamerid, ndikofunikira kuwongolera dera la chiwindi, kuyezetsa magazi a biochemical mayeso a chiwindi ndi kuyesedwa kwa magazi kuchipatala pakuchepa kwa maselo oyera am'magazi, hemoglobin ndi mapulosi.
Makamaka chidwi ayenera kuperekedwa kwa mowa pa mankhwala ndi diamerid. Vuto ndilakuti mowa umatha kuchuluka ndikuchepetsa mphamvu ya hypoglycemic ya mankhwala.
Pamaziko a glimepiride, kukonzekera kofanana ndi Diamerid kwapangidwa. Amapangidwanso kuti azichiza matenda amtundu wa 2 shuga. Izi zikuphatikiza:
- Amaryl amapezeka pamapiritsi a 1 mg, 2 mg, 3 mg ndi 4 mg, omwe ali ndi mapiritsi 30, 60 ndi 90, ku Germany,
- Glimepiride ndi mankhwala apakhomo, opangidwa mumtundu womwewo, phukusi limakhala ndi miyala 30,
- Glimeperid-Canon 2 ndi 4 mg, wophatikizidwa ndi mapiritsi 30, wopanga Russia,
- Mapiritsi a Glimepiride-Teva a 1, 2 ndi 3 mg ali ndi mabokosi azidutswa 30 ndi 60, mankhwalawo amachokera ku Croatia.
Ma analogues otsalawa (Glumedeks, Glyme, Glemauno, Glemaz, Meglimed) sapezeka mumaneti a Russia.
Diameride ndi mawonekedwe ake amafotokozedwa kuchokera ku pharmacies ndi mankhwala.
Diameride mu pharmacy itha kugulidwa pamtengo wa 202 - 347 rubles. Kutsika mtengo kwambiri ndi glimepiride. Mtengo wa ma CD ndi ma ruble 25 okha. Mtengo wa Glimepiride-Canon ndi Glimepirida-Teva pafupifupi wofanana, ndi ma ruble 122-132. Mtengo waukulu kwambiri ku Amaril. Mtengo umachokera ku ruble wa 150 mpaka 3400., Amaril ali ndi mtengo wokwera kwambiri wa 4 mg, woikidwa m'mabokosi a mapiritsi 90.
Tasanthula malangizo ogwiritsira ntchito Diamerid ndi mitengo ya analogues, titembenukira ku zowunikirazo.
Kwa odwala matenda ashuga, omwenso amamwa mankhwala ochepetsa shuga kwa nthawi yayitali, Diamerin ndi chida chothandiza komanso chothandiza chomwe chimapangitsa moyo wabwino. Kuphatikiza apo, mankhwalawa, amaika shuga m'magazi ndikuwasunga mokwanira, amateteza wodwala ku zovuta zovuta zomwe zimayambitsa matenda a shuga, monga polyneuropathy, retinopathy, diabetesic microangiopathy, ketoacidosis, hypoglycemic ndi hyperglycemic.
Chofunikira kwambiri pakuchiritsa bwino ndikutsatira malangizo a dokotala.
Njira zamankhwala osokoneza bongo
Masiku ano, mankhwala amakono amagwiritsa ntchito imodzi mwa magulu angapo a mankhwalawa kuchiza matenda amtundu wa 2. Zolinga zazikulu zomwe zikuyenera kukwaniritsidwa chifukwa chogwiritsa ntchito mankhwalawa ndi monga:
- kukondoweza kwa insulin ya katemera wa insulin
- kuchepa insulin insulin
- kuyimitsidwa kwa kaphatikizidwe ka shuga ndikuchepetsa kuyamwa kwake m'magazi kuchokera m'matumboꓼ
- kukonza kukonzekera kwa chiŵerengero cha lipid tizigawo m'magazi.
Monga lamulo, chithandizo nthawi zonse chimayamba ndi kuperekedwa kwa mankhwala amodzi; ngati sangathe, mankhwalawa ophatikizika kapena limodzi ndi jakisoni wa insulin atha kutumikiridwa.
Magulu akuluakulu a mankhwalawa omwe amagwiritsidwa ntchito pochiza matenda amitundu iwiri:
- Mankhwala omwe amachokera ku sulfonylurea. Ubwino wawo waukulu ndi kulolera bwino mankhwala kwa odwala ambiri. Mwa kuchitapo kanthu, amachepetsa kukana kwa insulini ndikulimbikitsa kutulutsa kwa mahomoni ndi maselo a pancreatic.
- Njira zochokera pagulu la Biguanide zimaphatikizanso gawo la metformin. Ndi mphamvu ya metformin yomwe imathandizira kuchepetsa kubisirana kwa insulin, imakhudza bwino mawonekedwe a fez, ndikuwongolera mbiri ya lipid. Kusankha Mlingo wolakwika kumatha kubweretsa zovuta zambiri.
- Amayamwa
- Zokonzekera zochokera ku thiazolidinone zotumphukira zimathandiza kutsitsa shuga wamagazi ndikuwongolera mawonekedwe a lipid.
Ma alpha-glucosidase inhibitors kapena dipeptidyl peptides 4 amatchulidwanso kuti mankhwala; amakhala ndi phindu pa kuthetseratu kwa hyperglycemia ndikuwonjezera chidwi cha maselo a pancreatic beta ku glucose.
Chachikulu pharmacological zimatha mankhwala
Diameride ndi mankhwala ochokera pagulu lachitatu sulfonylureas. Nthawi zambiri amagwiritsidwa ntchito pofuna kuchiza matenda a shuga 2, ngati mankhwala othandiziridwa pakudya asanachitike komanso zolimbitsa thupi sanabweretse zotsatirapo zabwino.
Mankhwala amapezeka mu mawonekedwe a piritsi mitundu yambiri - imodzi, ziwiri, zitatu kapena zinayi za milligram yogwira ntchito yomwe ili ndi zina zowonjezera pazomwe zimapangidwira. Chofunikira chachikulu cha mankhwalawa ndi glimepiride.
Kupanga kwakukulu kwamankhwala kumakhala motengera zotsatirazi:
- zimawonjezera chidwi cha maselo ku insulin.
- yogwira zimakhudza kutsekedwa kwa njira za potaziyamu, chifukwa chomwe ndende yozungulirapo ya potaziyamu imakulirakulira ndi insulin secretion imayambitsidwa.
- zimakhudza bwino mulingo wa lipid.
- amathandizira kuchepetsa kuphatikizira kwa masamba.
Kuphatikiza apo, kugwiritsa ntchito mapiritsi kumathandizira zotsatira za insulini pakukoka kwa glucose ndi zotumphukira zimakhala.
Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito kuphatikiza mankhwala molumikizana ndi mankhwala ozikidwa pa metformin (amasintha kagayidwe ka metabolic) kapena insulin.
Ndemanga zingapo za odwala omwe amagwiritsa ntchito mankhwalawa zimawonetsa kulolera mosavuta komanso kuthamanga kwa mankhwalawa.
Malangizo ogwiritsira ntchito mankhwalawa
Malangizo ogwiritsira ntchito mankhwalawa akuti kuyamba kwa mankhwalawa kuyenera kuchitika ndi mankhwala otsika kwambiri a mankhwalawa. Chifukwa chake, kuyang'anira kwa metabolic kofunikira kumaperekedwa.
Mukamamwa mankhwalawa, wodwalayo amayenera kuwunika kuchuluka kwa shuga m'magazi, komanso chisonyezo cha glycosylated hemoglobin.
Kukhazikitsidwa kwa mankhwala, komanso kusankha kwa mankhwala oyenera, kumachitika kokha ndi adokotala. Pankhaniyi, kudzipereka palokha ndi koletsedwa.
Kulondola kotenga miyala ndikutsatira malangizo awa:
- Pazigawo zoyambirira za mankhwala, muyezo woyenera wovomerezeka wa mankhwalawo ndi milligram imodzi ya mankhwala othandizira kamodzi patsiku. Pakatha sabata limodzi kapena awiri, ngati pakufunika thandizo, mlingo wa tsiku ndi tsiku utha kuwonjezeredwa.
- Mulingo wovomerezeka wa mankhwalawa sayenera kupitirira mamiligalamu asanu ndi atatu a mankhwalawo, malinga ngati mankhwalawa amawonjezeka pang'onopang'ono komanso bwino, masiku khumi mpaka khumi ndi anayi.
- Mwa odwala omwe misempha ya magazi amawongolera bwino, mphamvu ya mankhwalawa imatheka chifukwa chotenga mamiligalamu anayi mpaka anayi a mankhwalawo. Mpaka pano, pali anthu ochepa omwe amafunika kuwonjezera mankhwalawa mpaka mamiligalamu asanu ndi atatu a mankhwalawa.
Ndi bwino kumwa mankhwala, kutsatira malangizo onse a dokotala. Katswiri wa zamankhwala amakhazikitsa nthawi ndi kuchuluka kwa kuvomerezedwa, kutengera ndi moyo wa wodwalayo, ntchito ndi kuchuluka kwa zochita zolimbitsa thupi. Monga lamulo, kugwiritsa ntchito mankhwalawa kumakhazikitsidwa kamodzi patsiku chakudya chachikulu (mwachitsanzo, m'mawa musanadye chakudya cham'mawa). Choyambirira ndichakudya choyenera komanso chokwanira (nkhomaliro, chakudya chamadzulo), ngati mankhwalawa adamwa. Kuphatikiza apo, ziyenera kukumbukiridwa kuti ngati, pazifukwa zina, mapiritsi adasemphana, palibe chifukwa chowonjezera mlingo wake pa mlingo wotsatira.
Pali nthawi zina pomwe dokotala angasinthe kuchuluka kwa mankhwalawa. Kuwongolera kumachitika ngati wodwala akuwonda kwambiri, pakhala kusintha pa moyo wa wodwalayo - kuchuluka kwake ndi kuchuluka kwa zakudya, kuchuluka kwa zochita zolimbitsa thupi, pamakhala chiwopsezo cha hypo- kapena hyperglycemia chifukwa cha zinthu zina.
Ndi ziti zotsutsana zomwe zimagwiritsidwa ntchito?
Ngakhale pali mndandanda wazabwino za mankhwalawo, ndikofunikira kuganizira mitundu yonse yazovuta zomwe zingachitike mutagwiritsidwa ntchito.
Choyamba, ndikofunikira kulabadira mndandanda wa zoletsa zomwe chithandizo cha Diomexide sichingachitike. Zina mwazinthu zazikuluzikulu zomwe zikuphatikizidwa ndi izi:
Chithandizo cha matenda a matenda a shuga 1, komanso poyerekeza ndi matenda a shuga kapena matenda a shuga kwa wodwala
- mawonetseredwe a hypoglycemia wodwala,
- Pamaso pa matenda a matenda opatsirana,
- matenda a chiwindi kapena impso amayamba.
- tsankho kapena hypersensitivity ku chimodzi kapena zingapo za mankhwalawa.
- pamaso pa lactose tsankho kapena lactase akusowa.
Mpaka pano, palibe chidziwitso chokwanira chokhudza momwe mankhwalawa amagwirira ntchito pochiza matenda a shuga kwa ana. Chifukwa chake, chithandizo cha odwala chotere (mpaka zaka khumi ndi zisanu ndi zitatu) sichosankhidwa. Kuphatikiza apo, zotsutsana zimaphatikizanso kumwa mankhwalawa kwa atsikana ndi amayi oyembekezera panthawi yoyamwitsa.
Mosamala kwambiri, mankhwala amalembedwa ngati pali chiopsezo chowonjezereka cha hypoglycemia, ngati pali zinthu zina zomwe zimafuna kuti wodwalayo asamutsidwe kuti apange jakisoni wa insulin pambuyo pakuchita opaleshoni, ngati pali matenda am'mimba.
Ndi zovuta zoyipa ziti zomwe zimagwiritsidwa ntchito ndi mankhwalawa zomwe zingachitike?
Chifukwa chosankha molakwika mlingo wa mankhwalawa, osagwirizana ndi malingaliro onse a dokotala yemwe akupezekapo, mawonedwe osiyanasiyana olakwika chifukwa chomwa mankhwalawo akhoza kuyamba.
Chimodzi mwazotsatira zoyipa ndizoti chiwopsezo chowonjezeka ndikukula kwa hypoglycemia kwa nthawi yayitali. Zizindikiro zazikulu zomwe zimayenda ndi izi:
- kulakalaka kwambiri ndi kumva njala nthawi zonse,
- kupweteka kwambiri m'mutu
- kusanza ndi kusanza
- kumangokhala wotopa ndi kufooka kwa thupi,
- kusakhazikika
- kulephera kulolera
- kuvutika kupuma
- chizungulire ndi kukomoka,
- kuchuluka kwa kuthamanga kwa magazi.
Kukhazikika kwa mankhwalawa kumathandizikanso kuti azitha kuchepa. Zodabwitsazi ndizakanthawi ndipo zimangoyendera zokha kwakanthawi.
Kuphatikiza apo, mawonekedwe owoneka ndi zoyipa zingakhale ndi:
- Matenda osiyanasiyana am'mimba. Ululu m'mimba ungachitike, kutsegula m'mimba kumatha.
- Kuphwanya chiwindi, kukula kwa chiwindi, jaundice kapena cholestasis.
- Kuchokera kuzungulira kwa magazi nthawi zina, thrombocytopenia, leukopenia kapena pancytopenia amawonekera.
- Kusokonezeka kwa mitsempha kumatha kuchitika, komwe nthawi zambiri kumawonetsedwa m'njira zosiyanasiyana zamkati - urticaria, kuyabwa kwa khungu kapena zotupa.
Mankhwala osokoneza bongo amachititsa kuti munthu azidwala matenda a shuga oopsa kwambiri, omwe amatha tsiku limodzi mpaka atatu.
Kodi mankhwala amatha kusinthidwa ndi mankhwala okhala ndi katundu wofanana?
Chida chake ndi mankhwala, omwe ndi osavuta kupeza m'masitolo azitawuni. Mtengo wake umasiyana kuchokera ku ma ruble 170 mpaka 600, kutengera mtundu, malo ogulitsa ndi kampani yopanga. Ndemanga za makasitomala zikuwonetsa kuti mankhwalawa amagwirizana kwathunthu ndizofunikira za "mtengo wapamwamba". Pali nthawi zina pamene mungaganizire zothana ndi mankhwala ndikupeza analogi yoyenera.
Masiku ano, msika wamakono wamankhwala umapereka kusankha mitundu ingapo yamankhwala osiyanasiyana, omwe kapangidwe kake ndi fanizo la Diamerid, kapena masanjidwe ake. Tiyenera kudziwa kuti mankhwala a analog amatha kukhala ndi mayina osiyanasiyana, operekedwa ndi makampani ena, koma ali ndi gawo lofananira lofanana ndi Mlingo wofanana. Nawonso ma synonyms amafanananso ndi pharmacodynamic, koma kapangidwe kake kamasiyana kwambiri ndi kapangidwe koyambirira (mwachitsanzo, mapiritsi a Diabeton MV).
Pali ma fanizo a Diamerid, omwe otchuka kwambiri ndi Amaryl, Glemaz, Glimepiride
Amaryl M ndi piritsi yokonzekera yomwe imapezeka mu mitundu yosiyanasiyana. Ili ndi katundu wofanananso ndi mawonekedwe ogwiritsa ntchito. Makhalidwe ake a mankhwalawa ndi osatheka kuthekera m'madera ena a dziko lapansi komanso mtengo wokwera mtengo. Mtengo wapakati umatha kuchoka pa ruble 300 mpaka 1000 papaketi (mapiritsi 30), kutengera mlingo ndi wopanga.
Glemaz - mapiritsi omwe amapezeka mu gawo la ma milligram anayi a chinthu chogwira. Phukusili limakhala ndi mapiritsi makumi atatu, mtengo wake umatha kuchoka pa 325 mpaka 865 rubles.
Glimepiride - ndi analogue ya mankhwala a Diamerid. Ubwino waukulu wa chida choterocho ndi mtengo wake wotsika kwambiri - kuchokera ku ma ruble 140 mpaka 390.
Kodi ndi othandizira othandiza kwambiri a hypoglycemic omwe angakuwuzani katswiri mu kanemayu.
Dzinalo Losayenerana
Dzinalo losayenerera la mankhwalawa ndi glimepiride. Zikutanthauza chida chogwira ntchito ngati mankhwala. Katunduyu ndi m'badwo wachitatu wa sulfonylurea.
Diamerid ndi mankhwala omwe amagwiritsidwa ntchito kutsitsa glucose wamagazi.
Mndandanda wa mankhwalawa malinga ndi ATX (anatomical, achire komanso gulu la mankhwala) ndi A10BB12. Ndiye kuti, mankhwalawa ndi chida chomwe chimakhudza chakudya cham'mimba komanso kagayidwe, kamapangidwa kuti athetse matenda a shuga, amadziwika kuti ndi chinthu cha hypoglycemic, chotengera cha sulfonylurea (glimepiride).
Mankhwalawa amapezeka pamapiritsi. Mawonekedwe a mapiritsiwo ndi linda lathyathyathya wokhala ndi bevel. Utoto umatengera kuchuluka kwa zosakaniza piritsi; zitha kukhala zachikaso kapena zapinki.
Mapiritsi amatha kukhala ndi 1, 2, 3 mg kapena 4 mg ya mankhwala othandizira.
Omwe amathandizira ndi: lactose monohydrate, magnesium stearate, povidone, microcrystalline cellulose, poloxamer, croscarmellose sodium, utoto.
Phukusi limodzi lili ndi matuza atatu, iliyonse ya ma PC 10.
Zotsatira za pharmacological
Mankhwalawa ali ndi vuto la hypoglycemic.
Kuchita kwa mankhwalawa kumakhazikika pakulimbikitsa kupanga kwa insulin ndi maselo a beta a pancreatic a Langerhans, komanso kukulitsa chidwi cha zolandilira minofu ku mahomoni ndikuwonjezera kuchuluka kwa mapuloteni a glucose transporter m'magazi. Kuchita pancreatic minofu, mankhwalawa amachititsa kukokoloka kwake ndikutsegulidwa kwa njira zama calcium zomwe zimadalira magetsi, chifukwa cha momwe ma cell amayambitsa.
Amachepetsa kuchuluka kwa gluconeogenesis m'chiwindi chifukwa cha kutsekeka kwa ma enzymes ofunikira, motero kukhala ndi zotsatira za hypoglycemic.
Mankhwala amakhudzanso kuphatikiza kwa maselo ambiri, kumachepetsa. Imalepheretsa cycloo oxygenase, kutsekereza kukhathamiritsa kwa arachidonic acid, kumakhala ndi antioxidant, kumachepetsa kuchuluka kwa lipid peroxidation.
Kodi kumwa diamerid?
Mukamamwa mankhwalawa, dokotala amayenera kuwunika kuchuluka kwa shuga m'magazi. Katswiriyu amawona kuchuluka kwa shuga m'magazi, omwe ayenera kumwa mankhwalawo. Mlingo wochepetsetsa womwe umagwiritsidwa ntchito, womwe ungagwire bwino ntchito.
Mankhwalawa amapezeka pamapiritsi. Mawonekedwe a mapiritsiwo ndi linda lathyathyathya wokhala ndi bevel.
Mlingo woyambirira ndi 1 mg patsiku. Ndi nthawi ya masabata 1-2, adokotala amawonjezera mlingo, ndikusankha zofunikira. Inunso simungathe, popanda kufunsa dokotala, kuyamba kumwa mankhwalawo kapena kusintha mankhwalawo, chifukwa ndi othandizira amphamvu, osagwiritsidwa ntchito molakwika omwe amakhala ndi zotsatirapo zoyipa.
Ndi shuga wolamulidwa bwino, mlingo wa mankhwalawa patsiku ndi 1-4 mg, kutsika kwakukulu sikumagwiritsidwa ntchito kwenikweni chifukwa chakuti amagwira ntchito kwa anthu ochepa okha.
Mukatha kumwa mankhwalawa, simuyenera kulumpha chakudya, chomwe chimayenera kukhala chofinya. Mankhwalawa ndiwotalikirapo.
Diameride tikulimbikitsidwa mtundu 2 shuga mellitus, ngati chithandizo ndi ochepa-carb zakudya ndi kuchita masewera olimbitsa thupi sapereka zotsatira zofunika.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa amakhudza kuthekera kwa kayendetsedwe ka kayendedwe chifukwa cha kupukusa kwa hypoglycemia, komwe kumayendetsedwa ndi kuchepa kwa ndende, kutopa kosalekeza komanso kugona. Kuthekera kochita ntchito yomwe imafunikira chisamaliro chokhazikika, kuphatikiza kuyendetsa magalimoto, kumachepetsedwa.
Mukamamwa, ndikofunikira kuganizira za mankhwalawa.
Simungayambe kumwa mankhwalawo kapena kusinthitsa mlingo womwe waperekedwa nokha, osakakumana ndi dokotala.
Kuchita ndi mankhwala ena
Mukamagwiritsa ntchito mankhwalawa ndi mankhwala ena, ndizotheka kufooketsa kapena kulimbitsa machitidwe ake, komanso kusintha kwa ntchito ya chinthu china, chifukwa chake ndikofunikira kudziwitsa adokotala za mankhwala omwe amagwiritsidwa ntchito. Mwachitsanzo:
- Ndi munthawi yomweyo makonzedwe a glimepiride ndi insulin, othandizira ena a hypoglycemic, zotumphukira za coumarin, glucocorticoids, metformin, mahomoni ogonana, angiotensin-akatembenuza enzyme zoletsa, fluoxetine, etc., hypoglycemia yayikulu imatha.
- Glimepiride ikhoza kuletsa kapena kupititsa patsogolo zotsatira za coumarin zotumphukira - anticoagulant othandizira.
- Mafuta, ma laxatives, T3, T4, glucagon amatha kuchepetsa mphamvu ya mankhwalawa, kuchepetsa mphamvu ya mankhwalawa.
- Ma H2 histamine receptor blockers amatha kusintha zotsatira za glimepiride.
Ndi munthawi yomweyo makonzedwe a glimepiride ndi insulin, ena othandizira a hypoglycemic, kukula kwa hypoglycemia ndikotheka.
Kuyenderana ndi mowa
Mlingo umodzi wa mowa kapena kugwiritsa ntchito nthawi zonse kumatha kusintha ntchito za mankhwalawo, kuonjezera kapena kuchepetsa.
Ma analogues ndi othandizira omwe amakhala ndi glimepiride ngati chinthu chogwira ntchito. Izi ndi mankhwala monga:
- Amaril. Awa ndi mankhwala aku Germany, piritsi lililonse lomwe mumakhala mulingo wa 1, 2, 3 kapena 4 mg. Kupanga: Germany.
- Glimepiride Canon, Yopezeka mu Mlingo wa 2 kapena 4 mg. Kupanga: Russia.
- Glimepiride Teva. Amapezeka mu Mlingo wa 1, 2 kapena 3 mg. Kupanga: Croatia.
Diabetes ndi mankhwala osokoneza bongo a hypoglycemic, ali ndi vuto lofanana la hypoglycemic, koma zomwe zimagwira ndi zotumphukira za m'badwo wachiwiri.
Amaryl ndi analogue ya Diamerid. Awa ndi mankhwala aku Germany, piritsi lililonse lomwe mumakhala mulingo wa 1, 2, 3 kapena 4 mg.
Ndemanga za Diamerida
Musanagwiritse ntchito mankhwalawa, muyenera kudziwa za ndemanga zake.
Starichenko V. K: "Mankhwalawa ndi chida chothandiza kuthetsa matenda ashuga a 2. Ndizololedwa kugwiritsa ntchito limodzi ndi insulin kapena monga monotherapy. Ndi dokotala yekhayo amene angakupatseni mankhwalawa komanso kusintha. ”
Vasilieva O. S.: "Mankhwalawa amachepetsa kuchuluka kwa shuga m'magazi, kupewa zotsatira zosasangalatsa za shuga. Katswiri wokha ndi amene ayenera kulemba mankhwalawo komanso kudziwa mtundu wa mankhwalawo. ”
Galina: "Mwazi wa shuga unakwera kwambiri, mankhwala omwe ali ndi mphamvu yokhazikika ya glimepiride adalembedwa. Mapiritsi ndi omasuka, kumeza bwino, kumwa tsiku lililonse musanadye chakudya cham'mawa. Mafuta a m'magazi ndi abwinobwino, ndipo zizindikiro zosangalatsa za matenda ashuga zatha. ”
Natasha: "Mayi anga ali ndi matenda ashuga, mankhwala enanso sanathandize, adokotala adatinso amathandizira kupanga insulin komanso imapangitsa chidwi cha maselo kudziwa. Shuga ndi wabwinobwino, amatenga pafupifupi chaka. "
Diameride 4 mg: malangizo a ntchito ndi fanizo la mankhwala
Chithandizo choyambirira cha matenda a shuga a 2 nthawi zonse chimakhala chokhazikitsidwa ndi chithandizo chamankhwala chokhazikika komanso masewera olimbitsa thupi. Mankhwala a Diamerid amalembedwa chifukwa chosagwira ntchito mwa njirazi.
Kugwiritsa ntchito mankhwala ngati kumeneku kumavomerezana ndi adotolo, omwe amakupatsani mankhwalawo, potengera chithunzi chachikulu cha matenda omwe wodwalayo ali nawo, kuopsa kwa matendawa.
Njira yothandizira achire iyenera kukhala ndi mitundu yosankhidwa moyenera kuti mupewe kuwonetsa koyipa kwa mankhwala monga Diamerid.
Amaril yotsitsa shuga: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi
Amaryl ndi mankhwala omwe amathandiza kuchepetsa shuga m'magazi.
Kudya kwake kumayambira pomwe kusowa kwa insulini sikungaperekedwenso chifukwa cha njira zina - zochizira, zakudya, mankhwala wowerengeka, koma palibe chifukwa chobweretsa insulin yoyenera.
Kumwa mankhwalawa kumathandiza anthu omwe ali ndi matenda ashuga, omwe atha kusintha kwambiri moyo wawo.
Chifukwa chake, Amaryl, analogues omwe amapangidwa ndi makampani osiyanasiyana azamankhwala, amagwiritsidwa ntchito kwambiri pothandizira pakukonzekera kwa insulin m'thupi.
Zizindikiro ndi ntchito yogwira
Amaryl ndi mawonekedwe ake amasonyezedwa matenda amtundu wa II.Chofunikira chachikulu cha mankhwalawa ndi glimepiride.
Mankhwala a m'badwo wachitatu, omwe adapangidwa pamaziko a sulfanylurea, amachitapo kanthu kapamba, pang'onopang'ono kukweza maselo ake a b, omwe ali ndi udindo wopanga insulin. Mothandizidwa ndi kapamba, kapamba amapanga insulini yambiri, ndipo kuchuluka kwa shuga m'magazi kumatsika.
Mapiritsi a Amaryl 2 mg
Kuphatikiza apo, chinthu chogwiritsa ntchito mankhwalawa chimathandizanso paziphuphu zamthupi, kuchepetsa kukana kwawo kwa insulin. Izi ndichifukwa choti glimepiride, ikalowa mu khungu kudzera mu nembanemba, imatha kuletsa njira za potaziyamu. Zotsatira za izi, makatani a calcium a cell otseguka, calcium imalowa mu cellular cell ndikuthandizira kupanga insulin.
Zotsatira zamachitidwe awiriwa, kuchuluka kwa shuga m'magazi kumakhala pang'ono komanso pang'ono koma kwa nthawi yayitali kumachepetsedwa. Amaril ndi ma analogs amasiyana mibadwo yam'mbuyomu chifukwa cha zoyipa zochepa, zotsutsana ndi zovuta za hypoglycemia chifukwa chakudya.
Makhalidwe a mankhwalawa amakupatsani mitundu yambiri yomwe mankhwalawa amagwiritsidwa ntchito pochizira, zindikirani kuti wodwalayo ndi woyamba kukana ndi Amaril, ndikugawa moyenera mankhwalawa tsiku lililonse la mankhwalawa.
Mlingo wa Mlingo ndi Kusankhidwa Kwa Mlingo
Mankhwalawa, monga mtundu uliwonse wa Amaril, amafunikira kukonza ndikusankha kuyeserera kwa mankhwala omwe amafunikira.
Palibe zikhalidwe pano - wodwala aliyense amawona chimodzimodzi. Chifukwa chake, kusankha kwa mankhwalawa kumapangidwa pokhapokha pang'onopang'ono popanga shuga wamagazi pambuyo pa mtundu wina wa mankhwalawo.
M'masiku oyamba ovomerezeka, wodwalayo amapatsidwa mlingo woyambira, womwe ndi 1 mg wa Amaril patsiku. Ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono, kuwunikira kuchuluka kwa shuga. Kuchulukaku kumachitika milligram imodzi pa sabata, nthawi zambiri - m'masabata awiri.
Nthawi zambiri, muyeso waukulu womwe umaperekedwa kwa wodwala ndi magalamu asanu ndi limodzi a mankhwalawo. Pokhapokha povomerezeka ndizovomerezeka kuchuluka kwa tsiku ndi tsiku mpaka 8 mg, koma ndikofunikira kumwa mankhwalawa moyang'aniridwa ndi katswiri.
Amaryl imapezeka mu mapiritsi okhala ndi magawo awiri mpaka asanu ndi limodzi a yogwira ntchito. Mlingo wa mapiritsi akuwonetsedwa pa phukusi. Ndikofunika kumwa mankhwalawa pakamwa, osatafuna, ndimadzi ambiri. Amayeserera kumwa mankhwalawa kamodzi patsiku, koma nthawi zina, piritsi la Amaril likhoza kugawidwa pawiri.
Zotsika mtengo zotsutsa ndi ma fanizo
Mtengo wa mankhwalawa ndiwokwera kwambiri - kuchokera ku 300 mpaka 800 ma ruble. Popeza kuti kayendetsedwe kake kakuchitika, nthawi zambiri kwazaka zambiri, m'malo mwa Amaril ndizofunikira.
Mankhwalawa amachokera pazinthu zofananira zofananira, koma pakuwononga dzikolo ndipo kampani yopanga ikhoza kukhala yotsika mtengo kwambiri kuposa yoyambayo. Mankhwala otere amapangidwa m'mafakitale opanga mankhwala ku Poland, Slovenia, India, Hungary, Turkey, Ukraine. Amaril m'malo mwa ma analogues aku Russia amapangidwa kwambiri.
Mapiritsi a Glimepiride - analogue wotsika mtengo kwambiri a Amaril
Amasiyana mu dzina, ma CD, Mlingo ndi mtengo wake. Chosakaniza chophatikizira mwa iwo ndi chimodzimodzi. Pankhani imeneyi, pamayankho ake, mafunso otsatirawa salondola: "Kodi Amaryl kapena Glimepiride ndi chiyani?" Kapena "Amaryl ndi Glimepiride - pali kusiyana kotani?"
Chowonadi ndi chakuti awa ndi mayina awiri amalonda a mankhwala ofanana ndendende. Chifukwa chake, sikolakwika kuyankhula za ukulu wa njira ina iliyonse - zikufanana pakapangidwe kake ndi momwe thupi limagwirira ntchito.Glimepiride yopanga Russian ndi chiwonetsero chotsika mtengo kwambiri cha mankhwalawo.
Amapangidwa monga mapiritsi, ndi mulingo wa 1, 2, 3 ndi 4 mamililita.
Mtengo wa mankhwalawa ndiwotsika kangapo poyerekeza ndi Amaril yemweyo, ndipo chinthu chomwe chikugwirika ndi chimodzimodzi.
Ngati simungathe kupeza, mutha kugula Diamerid. Mapiritsiwa amasiyana mayina ndi wopanga okha. Analogue iyi ya Amaril imapangidwanso m'mapiritsi kuchokera 1 mpaka 4 mg, koma imasiyana ndi Glimepiride pamtengo wokwera pang'ono.
Opanga ku Ukraine mankhwala amapereka mankhwala Glimax, omwe ali ndi mawonekedwe ofanana. Amasiyana muyezo - piritsi ili ndi mamiligiramu awiri kapena anayi a yogwira, mapiritsi 1 mg sapezekapezeka.
Mapiritsi Diamerid 2 mg
Komanso, mitundu yotsika mtengo ya Amaril imapangidwa ndi makampani opanga mankhwala ku India. Mayina awo amalonda ndi Glimed kapena Glimepiride Aykor. Mapiritsi amodzi kapena anayi a milligram alipo. Muthanso kupezeka pamsika wogulitsa mankhwala aku India Glinova.
Kusiyana kwake kuli pokhapokha ngati kampani yopanga, yomwe ili ku India, ndi kampani yothandizira ya Briteni wopanga mankhwala ku Britain. Palinso mapiritsi a ku Argentina otchedwa Glemaz, koma ndiwokayikitsa kuti atchukanso makamaka m'mafakitare m'dziko lathu.
Mndandanda wa kupanga ku Israel, Jordan ndi EU
Ngati pazifukwa zina ogulira sakhulupirira opanga apakhomo kapena aku India, mutha kugula mitengo yotsika mtengo yochotsa Amaril, yomwe mtengo wake umakhala wokwera kuposa wa mankhwala apakhomo, koma wotsika kuposa wa mankhwala oyambirirawo.
Mankhwalawa amapangidwa ndi makampani ku Czech Republic, Hungary, Jordan ndi Israel. Odwala atha kukhala otsimikiza kwathunthu ndi mankhwalawa - njira yoyendetsera zamankhwala m'maiko awa imasiyanitsidwa ndi machitidwe ake okhwima.
Amix, yopangidwa ndi Zentiva, imaperekedwa kuchokera ku Czech Republic. Mlingo wokhazikika umachokera ku 1 mpaka 4 magalamu, kuluka kwapamwamba kwambiri komanso mtengo wokwanira kusiyanitsa mankhwalawa.
Kampani yotchuka yopanga mankhwala ku Hungary ya Egis, yomwe imayang'ana kwambiri pamisika ya CIS, imatulutsanso Amarila yayo. Chida ichi chimatchedwa Glempid, mulingo woyenera komanso mtengo wokwanira.
Hikma, kampani yayikulu kwambiri yamankhwala ku Jordanian, yomwe idakhazikitsidwa mu 1978, imakhazikitsanso mnzake waku Amaril, wotchedwa Glianov. Simuyenera kudandaula za kuchuluka kwa mankhwalawa - Mankhwala aku Jordani amatumizidwa kumayiko ambiri padziko lapansi, kuphatikiza USA, Canada ndi EU, komwe ulamuliro pazomwe zimagwiritsidwa ntchito kunja ndizovuta kwambiri.
Dzinja ladziko lonse Amaryl (generic) ndi Glimepiride.
Opanga ena
Mitundu yamitundu iyi yotchuka yothandizira kuchuluka kwa shuga m'magazi imapangidwa m'maiko ena padziko lapansi.
Zomera zopangira mankhwala ku Germany, Slovenia, Luxembourg, Poland ndi United Kingdom zimatulutsa mankhwala osiyanasiyana omwe amaloŵa m'malo mwa Amaryl. Komabe, mankhwalawa ndi okwera mtengo kwambiri, motero siabwino kwa odwala omwe ali ndi bajeti yochepa.
Mtengo waukulu kwambiri, wokwera pafupifupi 10 mtengo wa anzawo aku Russia kapena India, ndi ndalama zomwe zimaperekedwa ndi makampani opanga mankhwala ku Switzerland. Komabe, kupeza mankhwala okwera mtengo ngati awa sikumveka bwino - sizigwira ntchito bwino, ndipo kuzitenga kumayambitsa zotsatira zoyipa chimodzimodzi ndi zotengera zotsika mtengo.
Ndikofunikira kudziwa! Mavuto omwe ali ndi kuchuluka kwa shuga pakapita nthawi angayambitse matenda athunthu, monga mavuto amawonedwe, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba komanso ngakhale zotupa za khansa! Anthu amaphunzitsa zomwe zinawawa kuti azisintha shuga yawo kuti asangalale ...
Zambiri zothandiza pa Amaril mu kanema:
Palinso mankhwala osiyanasiyana ochokera kwa opanga osiyanasiyana ndi magulu osiyanasiyana amitengo omwe amalowa m'malo Amaryl. Dziwani kuti posankha mankhwala, simuyenera kudalira mtengo wake wokwera - sizitanthauza kuti nthawi zonse pamakhala mankhwala oyenera, nthawi zambiri mankhwala otsika mtengo samagwiranso ntchito kuposa mnzake wotsika mtengo.
Diameride: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi
Mankhwalawa a shuga mellitus, pamene zakudya ndi zovuta zolimbitsa thupi sizothandiza, mapiritsi amayankhidwa kuti muchepetse kuchuluka kwa shuga. Pali zinthu zingapo zogwira ntchito. Chimodzi mwa izo ndi glimepiride. Pamaziko ake, mankhwala osiyanasiyana amapangidwa. Ganizirani malangizo a Diameride omwe ali ndi zomwe zalembedwazi, yerekezerani ndi fanizo.
Zotsatira zoyipa
- achina,
- kusapeza bwino mu chakudya cham'mimba (mseru, kusanza, ndi zina),
- kuwonongeka kwamawonekedwe
- kuchuluka kwa chiwindi michere (mpaka chiwindi kulephera),
- hematopoietic matenda,
- thupi lawo siligwirizana
- anaphylactic shock,
- hyponatremia,
- zithunzi.
Zosafunikira zimasokonezedwa ndikusiya mankhwala kapena mwakuwunikiranso kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito.
Kuyanjana kwa mankhwala osokoneza bongo
Mphamvu ya mankhwalawa imatheka ndi zinthu zotsatirazi:
- ACE zoletsa ndi Mao,
- mankhwala osapweteka a antiidal
- cimetidine
- mafupa
- mankhwala antifungal
- salicylates,
- disopyramids
- fenfluramine,
- Hypoglycemic mankhwala (acarbose, biguanides, insulin),
- ganethidine,
- chloramphenicol,
- machez
- fluoxetine
- theofylline
- coumarin anticoagulants,
- odana ndi chifuwa chachikulu
- sulfonamides,
- anabolic steroids
- cyclophosphamides,
- beta blockers,
- pentoxifylline
- bromocriptine
- pyridoxine
- tubular secretion blockers,
- yotsalira
- allopurinol.
Zochita za Diamerid zimafooka ndi:
- barbiturates
- antiepileptic mankhwala
- glucocorticosteroids,
- adrenostimulants
- chlortalidone
- kopambana
- kaboni anhydrase zoletsa,
- blockers a "pang'onopang'ono" calcium njira,
- thiazide okodzeya,
- danazol
- mangochinos
- isoniazid
- katsitsumzukwa
- nicotinic acid
- diazoxide
- rifampicin
- morphine
- mchere wa lithiamu
- salbutamol,
- chlorpromazine
- ritodrin
- baclofen
- terbutaline
- glucagon,
- kukonzekera kwa chithokomiro,
- kulera kwamlomo ndi estrogens.
Mankhwala omwe amalepheretsa mafupa a hematopoiesis, akaphatikizidwa ndi diamerid, amawonjezera chiopsezo cha myelosuppression.
Kugwiritsa ntchito ma beta-blockers, clonidine, reserpine, guanethidine amatha kuphimba zizindikiro za hypoglycemia.
Dotolo ayenera kudziwa kuti wodwala amatenga ndalama zomwe zalembedwazo popereka mankhwala kuti athe kuwunika momwe angachitire nawo limodzi mankhwalawo.
Malangizo apadera
Ndikofunikira kuyang'anira shuga yanu nthawi zonse kuti mupewe mavuto.
Mankhwala amatha kuthana ndi kuyendetsa galimoto, kotero kuyendetsa galimoto ndikugwira ntchito ndi makina ndikosayenera.
Oyenera kuphatikiza mankhwala, kuphatikiza ndi insulin.
Wodwala ayenera kudziwa zizindikiro za hypoglycemia komanso athe kupereka thandizo. Vutoli lingayambitsenso:
- kumwa mowa
- kusala
- kuphwanya zakudya ndi mankhwala,
- zolimbitsa thupi
- kusintha kwa malo, ndege, ndi zina.
Mankhwala amaperekedwa pokhapokha ngati mwalandira mankhwala!
Fananizani ndi fanizo
Pali mankhwala angapo ofanana ndi omwe afotokozedwawa. Kukhala kofunikira kuzidziwa bwino ndi zomwe muli nazo ndikufanizira zomwe zachitikazo.
Diabeteson MV. Awa ndi mapiritsi okhala ndi gliclazide. Amapanga kampani "Service", France. Mtengo wa ma CD ndi ma ruble 300 ndipo pamwambapa. Iyi ndiye analogi yapafupi kwambiri muzinthu. Contraindication ndi muyezo, osavomerezeka kwa anthu okalamba.
Amaril. Mtengo wake umachokera ku ma ruble 300 mpaka 1000 phukusi lililonse (zidutswa 30). Kampani yopanga - Sanofi Aventis, France. Izi ndizophatikiza zochokera ku glimepiride ndi metformin. Chifukwa cha kuphatikiza kwa zinthu zimagwira mwachangu komanso mowongoka. Contraindication ndi muyezo, pali zovuta zambiri zoyipa.
NovoNorm. Mankhwala okhala ndi repaglinide. Pali mitundu itatu yamasulidwe, kutengera gawo la yogwira ntchito. Mtengo umayambira pa ma ruble a 180 phukusi lililonse. Wopanga - "Novo Nordisk", Denmark. Ichi ndi chida chotsika mtengo, chothandiza, koma chokhala ndi zotsutsana zingapo. Osakhala koyenera kwa ana, okalamba ndi amayi oyembekezera.
Glimepiride. Mtengo - kuchokera ku ruble 140 mpaka 390. Kampani yopanga mankhwala osokoneza bongo Pharmaceard, yopangidwa ndi kampani yaku Russia Vertex. Gawo lalikulu ndi glimepiride. Pali mitundu isanu pamsika yokhala ndi zinthu zosiyanasiyana zogwira ntchito. Imakhalanso ndi zofanana, zosakanikirana ndizofanana. Gwiritsani ntchito mosamala okalamba.
Maninil. Mankhwala ali ndi glibenclamide. Amapanga kampani "Berlin Chemie", Germany. Mtengo wotsika - ma ruble 120 a mapiritsi a 120. Ichi ndiye analogue wotsika mtengo kwambiri, pofotokoza za malo ndi kupezeka kwake. Milandu yomweyo.
Dokotala amasankha zomwe zingakhale bwino kwa wodwalayo ndikusamutsira ku mankhwala ena. Kudzipatsa nokha koletsedwa!
Maganizo a anthu odwala matenda ashuga omwe akudziwa zambiri pamankhwala amapezeka bwino. Anthu amawona kugwira bwino kwa mankhwalawa, owerengeka azotsatira zoyipa. Kwa ena, mankhwalawo sioyenera.
Olga: “Kwa nthawi yayitali ndakhala ndikuchiza matenda ashuga. Ndayesera mapiritsi ambiri, tsopano ndidayima ku Diamerida. Ndimagwiritsa ntchito Metformin, ndimakonda momwe mankhwalawo amathandizira. Shuga ndiwabwinobwino, osadandaula "mavuto". Ndipo koposa zonse, amagulitsidwa momasuka m'mafakisi. ”
Daria: “Ndinatenga Diameride kwa miyezi iwiri, shuga sanasinthe. Adotolo adati sanayenere mlandu wanga, ndipo adanenanso mankhwala ena. "
Oleg: “Dotolo adandiuza kuti ndimwe mapiritsi miyezi isanu ndi umodzi yapitayo. Zinthu zakhazikika. Kusinthasintha kwa shuga musadandaule; thanzi lonse ndilabwino. Ndibwino kuti uwu ndi mankhwala opangira zoweta, momwe zimakhalira ndi mawonekedwe sizoyipa kuposa ma analogu achilendo. Nanga bwanji kuchulukirachulukira ngati mwayi utapezeka kuti ulandilidwa ndi mankhwala otsika mtengo wofanana ndi womwewo. ”
Elena: “Ndili ndi matenda ashuga a 2. Zakudya zokha ndi zomwe zasiya kuthandiza, choncho endocrinologist wasankha Diamerid, akunena kuti zopangidwa ndi Russia, zabwino. Ndipo ndakhala ndikumuchiritsa kwa miyezi itatu. Ndizotheka kuti mutenge piritsi limodzi patsiku, ndipo zotsatira zake ndizitali. Shuga samadumphadumpha, hypoglycemia simachitika, zomwe ndizosangalatsa kwambiri. Ndipitilirabe kuchipatala. ”
Pomaliza
Kuganizira maunikidwe ake komanso momwe amagwiritsidwira ntchito mankhwalawa, ndi othandiza. Amadziwika kuti chiwerengero cha mtengo wamtengo amalemekezedwa, ndikupanga zoweta sizitulutsa mankhwalawa. Odwala matenda ashuga, komanso akatswiri, adziwa kuti Diamerid imagwira onse mu monotherapy komanso molumikizana ndi mankhwala ena.
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