Meldonium: malangizo ogwiritsira ntchito, zikuwonetsa kugwiritsa ntchito moduladira
Mildronate akupezeka mu mitundu yotsatsira iyi:
- Makapisozi: oyera, olimba a gelatin, kukula No. 1 (250 mg) kapena No. 00 (500 mg), zomwe zili m'matumba a kapisozi ndi purgrallopic crystalline yoyera yokhala ndi fungo lokomoka (m'matumba a ma PC 10, 2, 4 kapena 6 matuza. pamtundu wa makatoni),
- Njira yothetsera jakisoni: wopanda utoto, wowonekera (m'mapulogalamu a 5 ml, ma ampoules 5 m'matumba, mapaketi awiri mu katoni).
The kapangidwe 1 kapisozi zikuphatikiza:
- Chithandizo chogwira ntchito: meldonium dihydrate - 250 kapena 500 mg,
- Zothandiza monga: mbatata wowuma - 13.6 / 27.2 mg, colloidal silicon dioxide - 5.4 / 10.8 mg, calcium stearate - 2.7 / 5.4 mg.
Mapangidwe a chipolopolo cha kapisozi: E171 (titanium dioxide) - 2%, gelatin - mpaka 100%.
The 1 ml ya yankho likuphatikiza:
- Zogwira ntchito: meldonium - 100 mg (mu mawonekedwe a trimethylhydrazinium propionate),
- Gawo lothandiza: madzi a jakisoni.
Zizindikiro zogwiritsidwa ntchito
- Kuchepetsa mphamvu, kupsinjika kwa thupi (kuphatikiza osewera),
- Abstinence syndrome mu zakumwa zoledzeretsa (munthawi yomweyo ndi mankhwala ena auchidakwa),
- Matenda a mtima (a myocardial infarction, angina pectoris), mtima kulephera (monga gawo la chithandizo chovuta),
- Zovuta komanso zopweteka za kufalitsidwa kwamatumbo, kuphatikizapo mikwingwirima komanso kusowa kwa magazi (monga gawo la chithandizo chovuta).
Kuphatikiza pa Mildronate mwa njira yothetsera jakisoni:
- Thrombosis yamkati yam'mimba ndi nthambi zake,
- Hemophthalmus, retorr hemorrhages a osiyanasiyana etiologies,
- Retinopathies osiyanasiyana etiologies (hypertonic, diabetes).
Contraindication
- Kuchulukitsa kwachulukidwe (kuphatikiza ndi zotupa za intracranial, kusokonekera kwa venous kubuda),
- Hypersensitivity mankhwala.
Kupereka mankhwala kwa ana osakwana zaka 18, komanso kuyamwa ndi amayi apakati, sikulimbikitsidwa chifukwa cha kusowa kwa chidziwitso cha chipatala chotsimikizira chitetezo ndi ntchito yogwiritsidwa ntchito ndi Mildronate m'magulu a odwala.
Mildronate iyenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi matenda a impso ndi / kapena chiwindi (makamaka kwa nthawi yayitali).
Mlingo ndi makonzedwe
Chifukwa cha kuthekera kwakukondweretsa, Mildronate amalimbikitsidwa kuti agwiritsidwe ntchito theka loyamba la tsiku, mutatengedwa kangapo patsiku - osapitirira 17.00.
Mkati, Mildronate mu kapisozi kapamwamba nthawi zambiri amalembedwa motere:
- Matenda a mtima (a myocardial infarction, angina pectoris), mtima wosalephera: tsiku lililonse - 500-1000 mg, pafupipafupi makonzedwe - 1-2 patsiku. Kutalika kwa njira ya achire ndi miyezi 1-1.5 (munthawi yomweyo ndimankhwala ena),
- Dyshormonal cardiomyopathy: tsiku lililonse - 500 mg. Kutalika kwa njira ya achire ndi masiku 12 (munthawi yomweyo ndimankhwala ena),
- Ngozi zapakati za cerebrovascular (cerebrovascular insufficiency and stroke): tsiku ndi tsiku - 500-1000 mg, pafupipafupi makonzedwe - 1-2 kawiri pa tsiku. Kutalika kwa njira ya achire ndi miyezi 1-1.5 (mankhwalawa amatengedwa pakamwa nthawi yomweyo ndi mankhwala ena atatha maphunziro a jekeseni a Mildronate),
- Ngozi yovuta kwambiri yamitsempha: tsiku lililonse - 500 mg. Kutalika kwa njira ya achire ndi miyezi 1-1.5 (munthawi yomweyo ndimankhwala ena). Ndizotheka kuchititsa maphunziro obwereza (kawiri kawiri pachaka) mutakumana ndi azachipatala,
- Kuchepetsa magwiridwe antchito, malingaliro ndi thupi (kuphatikiza othamanga): tsiku ndi tsiku - 1000 mg, pafupipafupi makonzedwe - 2 kawiri pa tsiku. Kutalika kwa njira ya achire ndi masiku 10-14. Pambuyo pa masabata 2-3, maphunziro achiwiri ndi otheka,
- Kuleza matenda aakulu uchidakwa: tsiku lililonse 2000 mg, pafupipafupi makonzedwe - 4 pa tsiku. Kutalika kwa njira ya achire ndi masiku 7-10 (munthawi yomweyo ndi mankhwala a chidakwa).
Ochita masewera asanaphunzitsidwe amalimbikitsidwa kuti atenge Mildronate muyezo umodzi wa 500-1000 mg kawiri pa tsiku. Kutalika kwa maphunziridwe ake pakukonzekera kuli masabata awiri ndi atatu, nthawi ya mpikisano - masiku 10-14.
Mildronate mu mawonekedwe a yankho la jekeseni limayendetsedwa kudzera mkati ndi parabulbarno.
Monga lamulo, mankhwala osokoneza bongo amalembedwa:
- Matenda a mtima: tsiku lililonse - 500-1000 mg (5-10 ml ya yankho la jakisoni, ndende - 500 mg / 5 ml), pafupipafupi kugwiritsa ntchito 1-2 pa tsiku. Kutalika kwa maphunzirowa ndi miyezi 1-1.5 (munthawi yomweyo ndimankhwala ena),
- Ngozi ya cerebrovascular (gawo pachimake): tsiku ndi tsiku - 500 mg, pafupipafupi - 1 nthawi patsiku. Yankho limaperekedwa kwa masiku 10, pambuyo pake amasintha kutenga Mildronate pakamwa (500-1000 mg patsiku). Kutalika konse kwa maphunzirowa ndi miyezi 1-1.5,
- Kupsinjika kwakuthupi ndi kwamaganizidwe: tsiku ndi tsiku - 500 mg, pafupipafupi - nthawi imodzi patsiku. Kutalika kwa maphunzirowa ndi masiku 10 mpaka 14. Pambuyo pa masabata 2-3, maphunziro achiwiri ndi otheka,
- Kuledzera kosatha: tsiku lililonse - 1000 mg, pafupipafupi kugwiritsa ntchito - 2 kawiri pa tsiku. Kutalika kwa maphunzirowa ndi masiku 10 mpaka 14.
Ngati mtima pathologies ndi dystrophic matenda a retina, Mildronate ayenera kutumikiridwa parabulbarly muyezo wa 0,5 ml ya jekeseni yankho ndi ndende ya 500 mg / 5 ml kwa masiku 10.
Zotsatira zoyipa
Nthawi zina, kugwiritsa ntchito Mildronate mitundu yonse ya mankhwalawa, zotsatirapo zake zimatha kukhala izi: kuyamwa, khungu ndi khungu, urticaria, zotupa pakhungu, angioedema, dyspepsia, tachycardia, kuchuluka kapena kuchepa kwa magazi, kuwonjezeka kwa kusokonekera.
Nthawi zina, kukula kwa eosinophilia ndi kufooka wamba ndikotheka.
Kuyanjana kwa mankhwala osokoneza bongo
Pogwiritsa ntchito nthawi yomweyo Mildronate ndi mankhwala ena, zotsatirazi zosavomerezeka zingachitike:
- Coronary dilating agents, mankhwala ena a antihypertensive, mtima glycosides: kuchuluka kwa zochita,
- Nitroglycerin, nifedipine, alpha-adrenergic blockers, antihypertensive mankhwala ndi zotumphukira vasodilators: chitukuko cha ochepa hypotension, tachycardia woyenera (kusamala kuyenera kugwiritsidwa ntchito mukamagwiritsira ntchito kuphatikiza kotero).
Mildronate imatha kutumikiridwa nthawi imodzi ndi mitundu yayitali ya nitrate, mankhwala ena antianginal, antiplatelet othandizira ndi anticoagulants, antiarrhythmic, bronchodilator ndi mankhwala a diuretic.
Chikhalidwe cha mankhwala osokoneza bongo
Mankhwalawa amathandizidwa kuti azichita masewera olimbitsa thupi, azithamanga kwambiri komanso azitha kukumbukira komanso kuti asamalire kwambiri.
Ndi matenda a mtima ndi ischemia, imabwezeretsa kuperekera kwa oxygen m'maselo. Zimawonjezera kugwira ntchito kwa malingaliro ndi thupi, kumachotsa zovuta za kupsinjika kwa malingaliro, kumakhala ndi zotsatira zamtima.
Mankhwalawa amagwiritsidwa ntchito chifukwa cha kulephera kwa mtima komanso mankhwalawa. Kutulutsa Fomu - makapisozi ndi yankho la jakisoni.
Mankhwalawa amathandizanso chitetezo chathupi komanso kukana nkhawa.
Mankhwalawa amafupikitsa kuchira pambuyo pakumwa ischemic, amathandizira kuchepetsa gawo la necrosis.
Mankhwalawa amathandiza kuti achepetse matenda a angina. Amagwiritsidwa ntchito kuti apititse kupirira kuthamanga. Titha kupereka mayankho oyenera ku mayeso obwereza. Mankhwalawa amathandizira kuwonjezera magazi kupita ku malo a ischemia, omwe amafulumira kukonzanso dera lomwe lakhudzidwa.
Mildronate amathandiza kuchepetsa ziwopsezo za angina.
Mankhwalawa adapangidwa kuti apangidwe ndi matenda omwe amapezeka mu fundus. Mankhwalawa ali ndi mphamvu ya tonic, motero tikulimbikitsidwa kuti mugwiritse ntchito m'mawa. Mankhwalawa amalembera shuga ngati chothandiza.
Kuyerekeza kwa Meldonium ndi Mildronate
Mankhwalawa ali ndi mawonekedwe ofanana komanso omwe amagwira ntchito - meldonium dihydrate. Zisonyezero zakugwiritsa ntchito mankhwalawa:
- matenda a mtima
- zovuta zamagazi muubongo,
- kusiya achire odwala odwala kwambiri uchidakwa,
- kupsinjika kwamalingaliro ndi thupi,
- matenda am'mbuyo,
- kuchira nthawi pambuyo opaleshoni.
Contraindication amakhalanso ofanana kwa onse mankhwala:
- kuthamanga kwa magazi
- nthawi yoyamwitsa komanso pakati,
- ana ochepera zaka 18,
- kuchuluka kwachuma kwachuma.
Zotsatira zoyipa za mankhwalawa ndi zofanana:
- dyspeptic phenomena
- kuchuluka kwa kuthamanga kwa magazi,
- kugunda kwa mtima
- ziwengo
Wopanga mankhwala onsewa ndi Vidal. Mankhwala sayenera kuphatikizidwa ndi alpha-blockers ndi nitroglycerin. Kupanda kutero, mawonekedwe a tachycardia ndi otheka. Mankhwala onse awiriwa amagwiritsidwa ntchito mosamala mu matenda akulu a impso ndi chiwindi.
Kodi mankhwalawa ndi ofanana bwanji:
- zomwe zikugwira ntchito
- yemweyo mankhwala
- mndandanda womwewo wa zotsutsana ndi zotsatira zoyipa,
- kampani imodzi yomweyo.
Kodi Meldonium ndi chiyani? Malangizo, mitengo ndi malingaliro
Munkhani yachipatala iyi, mutha kudziwana ndi mankhwala a Meldonium. Malangizo ogwiritsira ntchito akufotokozera momwe mungamwe mapiritsi ndi jakisoni, zomwe mankhwalawo amathandizira, zomwe zikuwonetsa, magwiritsidwe ndi zotsutsana. Chofotokozedwacho chimapereka mtundu wa mankhwalawa komanso mawonekedwe ake.
Wothandizira anti-arrhythmic wa kalasi la IB, kusintha kagayidwe - kagayidwe kachakudya mthupi la munthu, ndi Meldonium. Malangizo ogwiritsira ntchito akuwonetsa kutenga makapisozi kapena mapiritsi a 250 mg ndi 500 mg, jakisoni m'miyeso ya jakisoni wochizira ngozi zam'magazi, kuchira kwamphamvu pamasewera, ischemic matenda a mtima.
Zofunika! Meldonium imadziwika ngati dope. Kugwiritsa ntchito pamasewera akatswiri ndi zoletsedwa!
Mankhwala
Metabolism enhancer, gamma-butyrobetaine analogue. Imachepetsa gamma-butyrobetaine hydroxynase, imalepheretsa kaphatikizidwe ka carnitine ndi kayendedwe ka mautali amafuta ambiri kudzera mumitsemvu yama cell, komanso kumalepheretsa kudziunjikira kwamitundu yamafuta aciccarnitine ndi acylcoenzyme A.
Mikhalidwe ya ischemia, imabwezeretsa bwino momwe magwiritsidwe ntchito a mpweya ndikuperekera ma cell, imalepheretsa kuphwanyidwa kwa kayendedwe ka ATP, ndipo nthawi yomweyo imayambitsa glycolysis, yomwe imachitika popanda kugwiritsa ntchito mpweya.
Zotsatira zakuchepa kwa ndende ya carnitine, gamma-butyrobetaine yokhala ndi masodilating amapangidwe kwambiri. Limagwirira ntchito limazindikira kusiyanasiyana kwake zotsatira zake zamankhwala: kuwonjezeka kwa mphamvu, kuchepetsa mphamvu ya kupsinjika kwa malingaliro ndi thupi, kutseguka kwa minofu ndi kusakhazikika pakulimbitsa thupi, mtima.
Kugwiritsa ntchito bwino
Pankhani ya kuwonongeka kwa pachimake kwa ischemic ku myocardium, kumachepetsa mapangidwe a necrotic zone ndikufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina.
Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic. Kugwiritsa kwa mtima ndi dystrophic matenda a fundus.
Imakhala ndi kukhudzika kwa chapakati mantha dongosolo, amachotsa magwiridwe antchito a mantha amthupi mwa odwala omwe ali ndi uchidakwa woperewera.
Kodi Meldonium ndi chiyani?
Zisonyezero zogwiritsidwa ntchito zimaphatikizapo zovuta mankhwala:
- kuchulukitsa kwakuthupi,
- maganizo achire mu zakumwa zoledzeretsa,
- Matenda a mtima wa Ischemic,
- Kuchepetsa magwiridwe
- ngozi zamisala,
- adalandir
- kukonzanso ntchito pambuyo.
Zomwe makonzedwe a parabulbar amathandizira kuchokera:
- retin vein thrombosis,
- retinopathies (matenda ashuga ndi hypertonic),
- matenda am'mimba
- zovuta zamagazi mu retina.
Malangizo ogwiritsira ntchito
Meldonium imalimbikitsidwa kuti itengedwe m'mawa, chifukwa imatha kupanga zosangalatsa. Mlingo umayikidwa payekha kutengera zisonyezo ndi njira yoyendetsera.
Mukamwa, pakamwa limodzi ndi 0,25-1 g, kuchuluka kwa kayendetsedwe kake komanso nthawi yayitali ya chithandizo kumatengera zomwe akuwonetsa.
0,5 ml ya jekeseni yankho ndi kuchuluka kwa 500 mg / 5 ml kutumikiridwa parabulbarly kwa masiku 10.
Ndi mtsempha wa magazi makonzedwe, mlingo ndi 0,5-1 g 1 nthawi patsiku, nthawi ya mankhwala zimatengera zikuwonetsa.
Ochita masewera amapatsidwa chithandizo chobwezeretsa malingana ndi njira zapadera kuphatikiza ndi njira zina. Odziwika mwapadera ngati dope.
Momwe mungatengere ndi matenda?
- Ngati kufalikira kwa matenda a ubongo, Meldonium imalimbikitsidwa nthawi yochulukirapo ya 0,5 g kamodzi patsiku kwa masiku 10, kenako osungidwa - 0,5 g tsiku lililonse kwa masiku 14 mpaka 14.
- Mu mtundu wa ngozi ya ubongo. Njira yothetsera jakisoni imaperekedwa intramuscularly pa 0,5 g kamodzi patsiku kapena kutumikiridwa pakamwa pa 0,25 g (pafupipafupi makonzedwe amatengera kuuma kwa mkhalidwe wa wodwalayo).
- Kuchotsa matenda kumafuna njira yochizira ndi Meldonium kwa masiku 7-10. Kenako wodwalayo akuwonetsedwa kumwa kwa mankhwalawa kanayi masana, 0,5 g mkati kapena nthawi ziwiri.
- Ndi khola la angina pectoris, masiku oyamba atatu a 3 ndi 3 ali 3,5 ga katatu. Kenako amatengedwa pakamwa kawiri pa sabata pa tsiku la 0,25 ga katatu. Kutalika kwa mankhwalawa ndikuchokera ku milungu 4 mpaka 6.
- Ndi cardialgia, kuphatikiza ndi dishormonal myocardial dystrophy, mankhwalawa amathandizidwa kudzera m'njira ya jet kamodzi patsiku, 0,5-1 g kapena IM mpaka 2 pa tsiku, 0,5 g patatha masiku 10 mpaka 14, mawonekedwe a kapisozi adayikidwa 0.25 mg m'mawa ndi madzulo, chithandizo chimapitilizidwa kwa masiku ena 12.
- Ndi mawonekedwe osasunthika a angina pectoris ndi infrction ya myocardial, Meldonium imagwiritsidwa ntchito kudzera m'mitsempha ya ndege ya 0,5 g kapena 1 g kamodzi patsiku. Pambuyo pake, amalembedwa pakamwa: masiku 3-4 - 0,25 ga 2 kawiri, ndiye masiku 2 pa sabata 0,25 g katatu pa tsiku.
- Pankhani ya mtima matenda a fundus, retinal dystrophy, Meldonium ndi zotchulidwa retrobulbarly ndi subconjunctively pa 0,05 g pakapita masiku 10.
- Matenda osalephera a mtima, mankhwalawa amaperekedwa mu jet tsiku lililonse pamankhwala a 0,5-1 g kapena m'malo ndi jakisoni wambiri wa 0,5 g mpaka 2 pa tsiku. Pambuyo masiku 10-14 chithandizo, wodwalayo amasamutsidwa 0,5 g makapu, omwe amatenga nthawi 1 m'mawa. Njira ya mankhwalawa imachokera ku milungu 4 mpaka 6.
Werengani komanso nkhaniyi: Ademethionine
Ana pa mimba ndi mkaka wa m`mawere
Meldonium sinafotokozeredwe kwa amayi apakati, chifukwa sizinali zotheka kutsimikizira chitetezo chake kwa mayi ndi mwana. Ngati mukufunikira kupereka mankhwala kwa mayi woyamwitsa, ndiye panthawi ya chithandizo, kuyamwitsa kumayimitsidwa: sizikudziwika ngati chinthucho chimalowa mkaka.
Mwa ana ndi achinyamata ochepera zaka 18, kugwiritsa ntchito bwino kwa meldonium sikunakhazikitsidwe. Meldonium mu mawonekedwe a makapisozi amatsutsana kuti agwiritsidwe ntchito mwa ana ndi achinyamata osakwana zaka 18, mu mawonekedwe a madzi ana osakwana zaka 12.
Malangizo apadera
Gwiritsani ntchito mosamala matenda a chiwindi ndi / kapena impso, makamaka kwa nthawi yayitali.
Pazaka zambiri pazachidziwitso cha infarction yacute myocardial infarction komanso angina osakhazikika m'madipatimenti a mtima amawonetsa kuti meldonium sikhala njira yoyamba yothandizira odwala pachimake coronary syndrome.
Kuchita
Pogwiritsa ntchito munthawi yomweyo Nitroglycerin, alpha-blockers, Nifedipine, zotumphukira vasodilators, pali mwayi wa tachycardia ndi ochepa hypotension. Imawonjezera ntchito ya antihypertensive, antianginal mankhwala, mtima glycosides.
Mwina kuphatikiza ndi antianginal mankhwala, anticoagulants, antiarrhythmic mankhwala ndi okodzetsa.
Zofunika! Osagwiritsa ntchito nthawi yomweyo limodzi ndi mankhwala ena okhala ndi meldonium.
Analogs a mankhwala Meldonium
Kapangidwe kamene kamayimira fanizo:
- Vasomag.
- Meldonium dihydrate.
- Idrinol
- Meldonium Organics (Binergia, Eskom).
- Angiocardyl.
- 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate.
- Cardionate
- Midolat.
- Medatern.
- Melfort.
- Mildronate
Zochizira kuchuluka kwa thupi ndi malingaliro, kuchira kwamthupi, analogi ndi mankhwala:
- Lamivit.
- Eleutherococcus Tingafinye.
- Cigapan.
- Yantavit.
- Falkamine.
- Ascovite.
- Galavit.
- Centrum.
- Cardionate
- Achimor.
- Hepargin.
- Triovit.
- Idrinol
- Eltacin.
- Corilip.
- Ribonosin
- Vazoton (L-arginine).
- Vasomag.
- Selmevit.
- Pikovit forte.
- Berocca Kuphatikiza.
- Pantogam.
- Heptolexin.
- Mildronate
- Vitatress.
- Ubiquinone compositum.
- Valeocor Q10.
- Pikovit.
- Kudewita.
- Carnitine.
- Dibikor.
- Trekrezan.
- Vitaspectrum.
- Elkar.
- Riboxin
- Vitamax.
- Pantocalcin.
- Ma antioxidants okhala ndi ayodini.
- Cytoflavin.
- Cropanol.
- Neoton.
- Nagipol.
- Mexicoidol.
- Jeriton.
- Oligovit.
- Duovit.
- Encephabol.
- Kudesan.
- Metaprot.
- Zowonjezera ndi chitsulo.
- Asvitol.
- Inosine.
- Vitrum Plus.
- Chuma cha Leriton.
- Drops Beresh Plus.
- Coenzyme compositum.
Maholide ndi mtengo
Mtengo wamba wa Meldonium (jakisoni a 5 ml No. 10) ku Moscow ndi ma ruble 145. Ku Ukraine, mutha kugula mankhwala a 195 hryvnia. ku Kazakhstan, malo ogulitsa mankhwala amapereka analogue of Mildronate. Ku Minsk, amagulitsa mankhwalawa kwa ma 4-6. ma ruble. Kuti mupeze mankhwalawa, muyenera kulandira mankhwala.
Potsatira maulalo, mutha kudziwa kuti ndi ma analogu ati omwe amagwiritsidwa ntchito pochiza matenda: kusiya matenda, uchidakwa, hemophthalmus, mbaleormomyopathy, sitiroko, kupweteka kwam'mimba, hemorrhage, angina pectoris, thrombosis, kupsinjika kwa thupi, kuperewera kwa mtima, kuperewera kwa mitsempha
Mildronate - momwe angatengere othamanga
Meldonium idapezeka mu 70s ya zaka za 20 ku Latvia Institute of Organic Synthesis ndipo poyambirira idagwiritsidwa ntchito monga chothandizira pakukula kwa mbewu ndi ziweto, ndipo pambuyo pake idayamba kugwiritsidwa ntchito pachipatala. Popita nthawi, madotolo adayamba kupereka mankhwala kwa matenda osiyanasiyana monga othandizira kagayidwe kake ndikuwalimbikitsa kuti osewera azitha kuchira.
Chifukwa chiyani meldonium imafunikira pamasewera
Kodiofiyoni ndi chiyani, ndipo angatengedwe ndi amateurs? Thupi limakhala ngati analogue ya gamma-butyrobetaine - enzyme yomwe imapezeka mu khungu lililonse laanthu.
Limagwirira a zochita za mankhwala. Meldonium imalepheretsa kupanga carnitine m'thupi ndipo imachepetsa kugwiritsa ntchito mafuta achilengedwe ngati mphamvu. Nthawi zambiri zimakhala mafuta omwe amawonongeka pomwe mphamvu zimagwiritsidwa ntchito ndi anthu omwe amakhala moyo wokangalika.
Ndipo mafuta acids amasinthidwa kukhala mphamvu m'minyewa ya mtima, yomwe imapangitsa mtima kugwira ntchito mwachangu. Kuchita kwa minimronate ndikumanganso ndikusintha ndikupanga mphamvu kuchokera ku glucose ndi oxygen. Izi zimachepetsa nkhawa pamtima ndi ziwalo zina zofunika.
Pazochita zake, mankhwalawo ndi osiyana ndi zowonjezera monga L-carnitine.
Cholinga chachikulu cha Mildronate ndi kukonza kagayidwe kazachilengedwe ndi mphamvu pama cellular.
Zothandiza meldonium pamasewera
- Imathandizira kuchira pambuyo polimbitsa thupi. Katunduyu ndiwofunika pamasewera aliwonse, mu masewera olimbitsa thupi akhoza kukhala masewera awiri ndi Cardio komanso mphamvu. Zinthu zowola zimatulutsidwa msanga m'maselo, ndipo njira zochira zimapitilira modabwitsa. Zotsatira zake, wothamanga amatha kuphunzitsa pafupipafupi komanso mwaluso.
- Kumapangitsa kuti thupi lizichita mantha komanso kugwira ntchito zolimbitsa thupi. Izi zokhala ndi zonyezimira zimakhala zothandiza kwambiri pakampikisano kapena pakuuma, pomwe zinthu zonse zamthupi zimatha msanga.
- Kuchita kwathunthu kumawonjezera ndipo kuchuluka kwake kumawonjezeka. Wothamanga amakhala wokalamba, wamphamvu, amawonjezera kuyenda komanso kuchuluka kwa nkhawa.
- Imathandizira kayendedwe ka glucose kupita ku maselo ndikuteteza mtima ku arrhythmias, angina pectoris. Uku ndiko kupewa matenda owopsa amtima monga kugunda mtima kapena sitiroko.
- Zothandiza kwa asthenia. Kumwa mankhwalawa kumakuthandizani kuti muchotse matenda a kutopa kwambiri, kugona ndi kufooka. Zonsezi, zachidziwikire, zimakhala ndi zotsatira zabwino pazotsatira zamasewera.
Meldonium ikhoza kugwiritsidwa ntchito pamtundu uliwonse wa katundu mu masewera olimbitsa thupi. Komabe, simuyenera kuyembekezera mutatenga kukula kwa zizindikiro ndi mphamvu yayitali ya minofu. Mankhwalawa samakhudza kukula kwa minofu mwanjira iliyonse, ndipo ngati kuwonjezeka kwa mphamvu kukuwonekera, ndiye kuti ndi kochepa.
Pa gawo la phindu lochulukirapo ndikuwonjezera mphamvu, ndikofunikira kugwiritsa ntchito meldonium kokha kuti mubwezeretse ndikuwonjezera mphamvu ya thupi.
Mildronate imakhala yothandiza kwambiri panthawi yayitali yochita masewera olimbitsa thupi. Amawonetsedwa othamanga, osewera mpira, oyendetsa skiers kuti apirire bwino komanso kusintha kamvekedwe ka mtima. Chimateteza othamanga kuti asalembe kwambiri.
Aliyense amadziwa milandu pomwe othamanga amakomoka pomwe pamasewerawa, popeza thupi silingathe kupirira chifukwa cha kuchuluka kwambiri.
Kugwiritsidwa ntchito kwa meldonium kumapewetsa mavuto ena mthupi.
Ngati mumadya kwambiri koma mukuphunzitsa, ndiye kuti kutenga Mildronate kumathandizanso. Chifukwa cha kagayidwe kachakudya kam'ma cell, kagayidwe kamachulukidwe ndikuwonjezereka.
Komabe, ndikofunikira kudziwa kuti sikofunikira kuphatikiza meldonium ndi mafuta ambiri, komanso zakudya zopanda mafuta a carbohydrate.
Gwero lalikulu lamphamvu mukamamwa Mildronate ndi glucose, chifukwa chake simuyenera kuchepetsa kuchuluka kwa zopatsa mphamvu komanso zovuta kuzimitsa, ngakhale mutayanika.
Zomwe meldonium imawerengedwa kuti ndiyopendekera
Mu Januwale 2016, Mildronate adaphatikizidwa pamndandanda wa mankhwala oletsedwa ndipo tsopano akuwoneka kuti ndi doping. Panthawiyo, kunamveka chiphokoso ndi osewera achi Russia omwe akhala akugwiritsa ntchito mankhwala osiyanasiyana kwa nthawi yayitali.
Chisangalalo chotere chidasewera m'manja mwa opanga meldonium, popeza malonda ogulitsa adakwera kwambiri. Lero, funso la zomwe zimafunikira kwa owonda sakhazikitsa akatswiri osati okhawo omwe amagwira ntchito zamasewera, komanso alendo wamba ochita masewera olimbitsa thupi.
Mpaka pano, madokotala ambiri samvetsa chifukwa chomwe meldonium imatchulira doping. Kupatula apo, adapangidwa kuti azithandizira thanzi komanso kusateteza, pakalibe kuyankhula za kuwonjezeka kwakukulu kwa kuthekera kwakuthupi.
Mtundu waukulu wakuletsedwa kwa Mildronate ndi mphamvu yake pa magwiridwe antchito a anthu, kuwonjezeka kwamphamvu komanso kopatsa chidwi.
Chifukwa cha izi, wothamanga yemwe akutenga Mildronate amakhala ndi mwayi mu mpikisano.
Ngati mumachita nokha, musawope kugwiritsa ntchito mankhwalawa. Kutengera miyezo, ndiotetezeka kwa thupi. Koma kwa osewera omwe amapikisana ndikupereka magazi kuti ayesere kuyesa, ndibwino kusiya meldonium kapena kugwiritsa ntchito kalekale zisanachitike.
Kugwiritsira ntchito mankhwala ngati mankhwala
Kuwonekera kosiyanasiyana kwa mankhwalawa kumapangitsa kuti ikhale yothandiza m'matenda osiyanasiyana. Mildronate amalembera mavuto otsatirawa:
- Matenda a bronchitis, mphumu ndi zina za ziwalo zopumira zomwe zimayenderana ndi kuperewera kwa mpweya,
- Kuphatikiza mankhwala a matenda a mtima - angina pectoris, kulowetsedwa kwamtima, mtima kulephera,
- Cerebrovascular ngozi
- Kupsinjika kwa nthawi yayitali komanso kutopa,
- Ngati mankhwala a hangover pachimake ndi uchidakwa matenda,
- Matenda amaso omwe amayambitsidwa ndi vuto lamagazi a retinal,
- Mitundu ina ya matenda a shuga.
- Nthawi yogwira ntchito kuti ichiritse ntchito mwachangu.
Ngakhale kuchuluka kwazinthu zabwino, meldonium, monga mankhwala aliwonse, ali ndi malire. Sichikulimbikitsidwa kuti chikhale ndi ana osaposa zaka 18, nthawi yomwe muli ndi pakati, ndimavulala a craniocerebral, kuvulala kwa venous kubuda, impso, chiwindi, komanso mavuto amanjenje. Kutsatira makonzedwe, zotsatirazi zoyipa ndizotheka:
- Kutsitsa magazi
- Kuchuluka kwa mtima,
- Hyperacaction.
Pofuna kupewa zovuta, tikulimbikitsidwa kugwiritsa ntchito Mildronate m'mawa osapitilira muyeso. Nthawi zina, sayanjana zimachitika, komanso kutentha kwa mtima, nseru pambuyo.
Momwe mungatengere meldonium kwa othamanga
Mankhwalawa amaperekedwa mu mawonekedwe a makapisozi, mapiritsi ndi madzi, omwe cholinga chake ndi pakamwa. Palinso njira yothetsera vutoli yomwe imatha kutumikiridwa kudzera m'mitsempha kapena intramuscularly.
Momwe mungatenge Mildronate kuti othamanga azitha kuchita bwino kwambiri? Inde, jakisoni wotsekemera amakhala wachangu kwambiri komanso wothandiza kwambiri.
Komabe, pankhaniyi, ndikofunikira kuyang'anira mosamalitsa ndi kukhala ndi luso la jakisoni, apo ayi zitha kukhala zovulaza thanzi. Ochita masewera a Amateur ndibwino kusankha piritsi ndi kapisozi.
Mukamamwa pakamwa, Mildronate amaledzera m'mawa theka la ola asanadye, kapena mphindi 30 atatha kudya. Mankhwalawa sangathe kuphwanyidwa kapena kutafunidwa, amameza lonse ndikutsukidwa ndi madzi ambiri.
Kuwongolera magwiridwe antchito, tikulimbikitsidwa kutenga meldonium pa 500 mg patsiku, ndiye kuti 250 mg kawiri pa tsiku kapena nthawi 1 patsiku 500 mg. Patsiku la maphunziro, muyenera kutenga zinthuzo theka la ola musanaphunzire.
Mlingo weniweniwo amawerengedwa ndi kulemera - 15-20 mg pa kilogalamu ya thupi. Kugamula komaliza sikuyenera kukhala kosachedwa kuposa 17.00 kapena osapitirira maola 5 asanagone kuti mupewe kuwonjezereka.
Akatswiri amatha kuonjezera kuchuluka kwa mankhwalawa katatu ndipo amamwe mankhwalawa kawiri pa tsiku.
Phukusi loyenera, meldonium imakhala ndi makapisozi 40 a 250 mg. Palinso mitundu ya kapisozi 60 ya 500 mg iliyonse. Mtengo muma pharmacies umasiyana kuchokera ku 230 mpaka 400 ma ruble.
Muthanso kupeza 10% yankho la Mildronate wa jakisoni - ma ampoules 10 a 5 ml. Mbale umodzi uli ndi 500 mg ya meldonium. Ndikofunikira kutsatira malangizo osasokoneza njira yovomerezeka ndi intramuscular.
Mutatsegula ampoule, mankhwalawa amayenera kubayidwa nthawi yomweyo, popeza mankhwalawa salola kuyanjana ndi mpweya kwa mphindi zoposa 5. Mtengo wa phukusi limodzi ndi jakisoni umachokera ku ma ruble 68 mpaka 150. Kutalika kotenga Mildronate ndi masabata 3-5.
Kenako muyenera kupuma kaye kwa mwezi umodzi kuti musazolowere thupi. Pambuyo pake maphunzirowo akhoza kubwerezedwa.
"Mildronate - chimathandiza ndi momwe tingachigwiritsire ntchito?"
Titha kunena popanda kukokomeza kuti palibe mankhwala ngakhale m'modzi m'mbiri yamakono yomwe "yalimbikitsidwa", komanso, kampani yopanga sikunapange ndalama pachiwonetsero chotsatsa padziko lonse lapansi. Tikuyankhula za zotsatizana zosokoneza mbiri mu "masewera akulu" momwe meldonium (INN), momwe amatchulidwira kunja, kapena Mildronat, monga amatchedwa ku Russia (dzina lamalonda), adayenera kutsutsidwa.
Zonsezi zidayamba pa Januware 1 omaliza, 2016. Inali nthawi imeneyi pamene WADA (World Anti-Doping Agency) imabweretsa meldonium, aka Mildronat, mndandanda wazachuma zoletsedwa.
Cholinga chake chinali chakuti cytoprotective ndi metabolic zotsatira zitha (mwina) kusintha myocardium kwambiri kuti mtima ukhale wolimba komanso wolimba kwambiri, zomwe zingapangitse kuti zitheke, motero ndalama zambiri.
Mbiri ya mankhwalawa idaphatikizika.
Inapangidwa koyamba mu Latvia SSR ndi Ivars Kalvins, ndipo poyamba amafuna kuti agwiritse ntchito pochotsa zinthu zakupha za rocket mafuta (dimethylhydrazine).
Koma pophunzira kuopsa kwa mankhwalawa mu nyama, zotulukapo zake zidapezeka kuti kuyambira 1976, mankhwala otchedwa Mildronate adalembedwa ku USSR, kenako ku USA (kuyambira 1984).
Sizikudziwika chifukwa chake, koma ku USA mankhwalawo anali "opanda nzeru": mmbuyomo m'zaka za m'ma 80 zapitazo anali oletsedwa. M'dziko lathu, kugwiritsa ntchito mapiritsi a Mildronate kunayamba ngati mankhwala ankhondo, kenako, kutha kwa USSR, adasanduka mankhwala ogwiritsidwa ntchito kwambiri machitidwe azachipatala wamba.
Zochita ndi magwiridwe antchito
Chithunzi cha Mildronate cha makapisozi ndi yankho la jakisoni
Mankhwala amachita pa minofu ya mtima kudzera kagayidwe mafuta acids. Zotsatira zake, kuchuluka kwa zinthu zomwe zimakhala ndi ma-oxidized mu ma myocardial cell - myocardiocytes - zimachepa, ndipo mwayi wa oxidation waulere umachepa. Nthawi zambiri, zinthu zonsezi zimasokoneza kayendedwe ka ATP - molekyulu yapadziko lonse - "batri", yomwe imapereka maselo onse ndi mphamvu.
Zotsatira zake, myocardiocytes amatha kugwiritsa ntchito bwino glucose, ndipo kupatsa mphamvu kwa myocardial kumakhala bwino. Ndipo izi zimatsogolera mwachidziwikire kuti mtima umayenda bwino ndikuwonjezera katundu. Kuphatikiza apo, ATP imagwira ntchito myocardium yokha.
Magulu angapo a asayansi apeza kuti mankhwalawa amapezeka bwino ngati thupi liyenera kugwira ntchito mwa malo a celloxia. Mildronate amalimbikitsa kuchira msanga pambuyo pogwira ntchito mwamphamvu, kuphatikiza kuchira kwam'maganizo.
Mankhwalawa amalola othamanga kuti angodzipereka okha momwe angathere ndikupereka "zonse zabwino" pakuphunzitsidwa. Komabe, si mahomoni, alibe mphamvu ya anabolic, ndipo sitsogolera pakukula kwa minofu. Zimalepheretsa kuwonongeka kwa mtima, zimathandizira kufalikira kwa neural, komanso kupewa ubongo wa hypoxia.
Zizindikiro ndi mawonekedwe akumasulidwa
Kodi chimathandiza Mildronate ndi chiyani? Mwachilengedwe, chikalata chovomerezeka (chomwe, mwa zina, WADA chimapangidwanso) ndizoyenera kugwiritsa ntchito. Mitundu yotulutsidwa kwambiri ndi makapisozi 250 ndi 500 mg, komanso mawonekedwe a makolo mu ampoules (5 ml) a 10% yankho. Njira yothetsera vutoli imayendetsedwa kudzera m'mitsempha, intramuscularly, ndi parabulbarno (mu ophthalmology).
Ganizirani mlingo woyenera - "Mildronate" 500, ndikutsegulira malangizo ogwiritsira ntchito:
- Mankhwala akuwonetsa angina pectoris ndi mitundu yosiyanasiyana ya myocardial ischemia, komanso matenda amtima woopsa,
- mankhwalawa aakulu mtima kulephera (otsika contractile myocardial ntchito),
- ndi cardiomyopathies ochokera kumayendedwe osiyanasiyana komanso ndi myocardial dystrophy,
- zomwe zimawonetsedwa chifukwa cha stroke ischemic, cerebrovascular pathology ndi dementia,
- kutopa ndi kuchepa kwa ntchito,
- ngati pali zochulukitsa, kuphatikiza masewera,
- mankhwalawa uchidakwa (ndi kuchotsedwa kwa zizindikiro zochotsa).
Umenewo ndiye umboni wonse. Koma, kwenikweni, mankhwalawa amatha kuwonjezera kupirira, amawonjezera kukana kupsinjika, amathandizira dongosolo lamkati lamanjenje, amathandizira kuchira kwa thupi.
Ichi ndichifukwa chake madokotala ambiri adayamba kupatsa Mildronate kwa wodwala aliyense, limodzi ndi matenda komanso kupewa.
Zowonadi, mankhwalawa adakhala "panacea" kwa anthu omwe akukayikira, nkhawa komanso hypochondria.
Amakhulupirira kuti ngati kupita kwa adotolo sikunathe ndi mankhwala omwe amupeza, ndiye kuti ulendowo sunaphule kanthu, ndipo dokotalayo ndi woipa. Mildronat amalemekeza izi.
Yang'anani! Ndikofunikira kumvetsetsa kuti "ma pluses" ake onse paliponse umboniwo akuti: "mankhwalawa amagwiritsidwa ntchito povuta."Izi zikutanthauza kuti padera Mildronate sangathe, ndipo sayenera kuchotsa myocardial ischemia, kapena kuchita chimodzimodzi. Zimangoyambiranso kuchira mwachangu.
Momwe mungagwiritsire ntchito mankhwalawa?
Mildronate imatha kukhala yosangalatsa, komanso imayambitsa chisokonezo cha kugona. Chifukwa chake, iwo omwe amagwiritsa ntchito kwa nthawi yoyamba, ndikulimbikitsidwa kuti asamamwe pambuyo pa 17.00 (ngati kugona mwakuthupi kumakonzekera usiku), koma ndibwino kuti muchepetse phwando lam'mawa. Pali mitundu yosiyanasiyana ya mankhwalawa omwe amamwa mankhwalawa, kutengera matendawa:
- Myocardial infarction ndi mitundu ya matenda a mtima ofunikira amafunika mpaka 1000 mg patsiku, mpaka miyezi 1.5. Phwando
- Ndi myocardial dystrophies ndi cardiomyopathies, 500 mg kamodzi ndikokwanira, kwa masiku 10-14,
- Mu pachimake cerebrovascular ngozi ya ischemic chikhalidwe (mikwingwirima, chosakhalitsa kuwukira), mankhwalawa kutumikiridwa m`nsinga, mwachitsanzo, kuphatikizapo shuga, insulin ndi potaziyamu mankhwala ena. Pambuyo pa jekeseni, 1000 mg imayikidwa tsiku lililonse m'mawa, kapena 500 mg ya Mildronate kapisozi (m'mawa ndi masana) kwa 1 mpaka 2 miyezi.
Kugwiritsa ntchito jakisoni wa Mildronate kumasonyezedwanso ngati borus ya intravenous. Tiyenera kukumbukira kuti mulingo umodzi mu 5 ml ndi wofanana ndi kapisozi "yayikulu" mu 500 mg ya mankhwalawa, chifukwa zomwe zili meldonium ndi 100 mg pa 1 ml yankho.
- Ngati matenda a cerebalvascular aakulu (ubongo atherosulinosis, matenda osokoneza bongo), mankhwala akuwonetsa 500 mg kamodzi patsiku, komanso kwa nthawi yayitali - mpaka miyezi iwiri,
- Kulandila othamanga, komanso kwa omwe achita masewera olimbitsa thupi, amalimbikitsidwa pa mlingo wa 500 mpaka 1000 mg tsiku lililonse. Kutalika kwakuvomerezedwa ndiku kuyambira pa 2 mpaka 3 milungu,
- Monga gawo la zovuta zochizira zakumwa zoledzeretsa, mankhwalawa akuwonetsa muyezo waukulu - mpaka 2000 mg patsiku, womwe umagawidwa mu 4 waukulu. Njira ya mankhwala yochepa - pafupifupi - masiku 7.
Anthu ambiri amafunsa - ndi chothandiza kwambiri: kumwa mapiritsi a Mildronate, kapena jakisoni? Kuti muyankhe funsoli molondola, muyenera kulozera ku ma pharmacokinetics ndi pharmacodynamics a mankhwalawo. Amadziwika kuti kuchuluka kwambiri m'madzi a m'magazi kumachitika pakatha maola 1 mpaka awiri atatha kumwa.
Mankhwala sayenera kudutsa m'chiwindi kuti ayambe kugwira ntchito. M'malo mwake, imawonongeka m'chiwindi, ndikusintha ma metabolites 3 mpaka 6 patatha nthawi yotsekemera.
Chifukwa chake, ndibwino kugwiritsa ntchito jekeseni, popeza pamenepa gawo loyambirira kudzera pachiwindi silili kwina (atamwa mankhwala a duodenum ngati makapisozi).
Zachidziwikire, chifukwa cha izi payenera kukhala mikhalidwe yonse komanso umboni woyenera.
Mildronate (meldonium) pamasewera: zowonadi, magwiridwe antchito, momwe angalandirire ndipo ndikoyenera?
Mbiri yakale yofewa (meldonium) pamasewera imayamba ndi wosewera wotchuka wa tennis ku Russia, dzina lake Maria Sharapova. Mu 2016, adakhala nyenyezi yakusokosera kokumbidwa, atayesedwa doping pa Australia Open.
Cholinga chake sichinali anabolic steroids, erythropoietin kapena mahomoni, koma mankhwala osokoneza bongo a Cardio, modzidzimutsa osati a Sharapova okha, koma gulu lonse la padziko lonse lapansi komanso ngakhale osewera omwe amakhala mwamphamvu pa pharmacology.
Munkhaniyi tikambirana zowona zokhuza zonenepa, kudziwa cholinga chake, zamankhwala, komanso zomwe zingachitike.
Zambiri pa Mildronate (Meldonium)
- Meldonium idapangidwa ndi kampani yopanga mankhwala yaku Latvia
- Meldonium ndi choletsa mafuta oxidation (amaletsa kuyaka kwawo)
- Kugwiritsira ntchito masewera olimbitsa thupi mopepuka kumaletsedwa ndi World Anti-Doping Agency (WADA)
- Chizindikiro chachikulu chogwiritsidwa ntchito ndi mankhwala osakaniza ndi chithandizo cha mavuto a mtima, koma mndandanda wazidziwitso ndiwofalikira kwambiri
- Meldonium ndi yoletsedwa kugwiritsidwa ntchito (yopanda chilolezo) ku United States, imaloledwa ku Russia ndi maiko ena omwe kale anali USSR bloc
- Mankhwalawa anali kugwiritsidwa ntchito kwambiri ndi asitikali aku Soviet Union pankhondo ku Afghanistan.
Kodi meldonium (modabwitsa) ndi chiani?
Meldonium idapangidwa ndi kampani yopanga mankhwala yaku Latvia Grendiks.
Limodzi mwa malangizo oyamba a Mildronate linali kukonza kuchuluka kwa ubala (umuna) ndi nkhumba zazimuna ndi ziweto zina. Pambuyo pake, kukula kunakulitsidwa kukhala 2.
- Kugulitsa mankhwalawa kunakwana ma miliyoni 56 miliyoni mu 2013, zomwe zidapangitsa Grendiks kukhala amodzi mwa ogulitsa kunja pamsika wazachipatala wa ku Latvia.
- Kuyambira 1979 mpaka 1989, Mildronat adapereka "kuyesa" kwakukulu kwa asitikali aku Russia: adatumizidwa ku Afghanistan kuchokera ku 1979 mpaka 1989.
- Chifukwa chiyani?
- Malinga ndi wopanga mapulogalamu a Ivan Calvins, momwe meldonium imathandizira ndikupereka kwa mpweya m'thupi.
- Asitikali adatenga meldonium pomwe ali kumapiri a Afghanistan, pomwe kunali kofunikira kunyamula zida zolemetsa: mankhwalawa adasintha chipiriro m'malo opumira mpweya.
Masiku ano, Mildronate ndi mankhwala omwe amagwiritsidwa ntchito ku Eastern Europe ndi Central Asia (mayiko omwe kale anali Soviet Union) kuchiza matenda ambiri, koma koposa zonse matenda amtima. Ku United States ndi mayiko ena ambiri, ndizoletsedwa.
Kuphatikiza pa kugwiritsa ntchito zachipatala, meldonium imagwiritsidwa ntchito kwambiri pamasewera ngati othandizira doping yomwe imasintha magwiridwe antchito.
Kuyambira kuchiyambiyambi kwa chaka cha 2016, pomwe Maria Sharapova adamubweretsera kutchuka, osewera ambiri ochokera kumayiko osiyanasiyana (kuphatikiza USA, Russia ndi mayiko aku Europe) adalembedwa ndi WADA kuti igwiritse ntchito.
Meldonium ndi mankhwala omwe cholinga chawo choyambirira chinali kuwonjezera kuchuluka kwa nkhumba. Masiku ano amagwiritsidwa ntchito kwambiri pochiza matenda amtima.
Chifukwa chiyani Mildronate adalembedwa ngati mankhwala?
Mankhwala, Mildronate amalembedwa kwa odwala omwe ataya magazi m'zigawo zina za thupi, makamaka, omwe ali ndi mavuto amtima komanso matenda amitsempha yamagazi (omwe amachepetsa mtima weniweni), pochiza matenda a angina ndi mtima.
Kafukufuku wa sayansi akutsimikizira kutha kwake pochiza matenda a mtima osalephera 4 ndi stroke 5.
M'mayiko ena, kuphatikiza Russia, Latvia, Ukraine, Georgia, Kazakhstan, Azerbaijan, Belarus, Uzbekistan, Moldova, ndi Kyrgyzstan, madokotala amathandizira kuti magazi azikhala ndi magazi ambiri.
Zawonetsedwa kuti zimathandizira kusintha kwa mawonekedwe ndikuwongolera ntchito yamagalimoto, zimachotsa chizungulire ndi mseru 8.
Komanso meldonium Imathandizanso kuona matenda osokoneza bongo atamwa mowa.
Zizindikiro zina pakugwiritsa ntchito Mildronate 6:
- zilonda zam'mimba
- kuvulala kwamaso
- matenda am'mapapo ndi kupuma.
Ngati muwerenga mosamala malangizo ogwiritsira ntchito moduladula, tidzaona kuti mapangidwe ake "akukonzanso zolimbitsa thupi", ngakhale gawo loti "silikuwoneka ndi masewerawa" lipezekanso pamenepo.
Pali chisokonezo, chifukwa zikuwonekeratu kuti chilichonse chomwe chimasintha magazi, chimakhala bwino. Zochita zakukonzekera doping yambiri ndizokhazikika pam mfundo iyi.
Malongosoledwe a WADA chifukwa chowonjezera meldonium pamndandanda wa mankhwala osokoneza bongo oletsa kuthamangitsidwa akuyang'ana kwambiri malowa: "meldonium imawonjezera kusewera pamasewera popereka mpweya ku minofu ndi minyewa."
Mankhwala, Mildronate adalembedwa kuti azithandiza magazi kupitilira ziwalo zosiyanasiyana, kuphatikizapo mtima ndi ubongo, komanso kuthana ndi zizindikiro za khomalo atamwa.
Mildronate (Meldonium) pamasewera
Kutchuka kwa masewera olimbitsa thupi pang'ono kunabwera ndi wosewera wa tennis wa ku Russia, Maria Sharapova, yemwe sanapereke ulamuliro woyipitsa mu Marichi 2016, miyezi itatu kuchokera pamene meldonium idalembedwa ndi WADA 1.
Adavomereza kuti adagwiritsa ntchito mankhwalawo kwa zaka 10 monga adalamulira adokotala. Onani kuwunika kwa mtima wama mtima pazakugwiritsa ntchito kwa meldonium Sharapova.
- Atazindikira izi, malonda a Mildronate adakula kangapo.
- Pafupifupi nthawi yomweyo ndi chiletso cha Sharapova, WADA idalandira skater Ekaterina Bobrova waku Russia ndipo chaka chomwecho, wopikisana padziko lonse lapansi mu 1500 m akuthamanga Abeba Aregawi, wopambana pa mpikisano wa Tokyo mu 2015 Endeshaw Negesse.
- Ma medali 13 a Masewera a ku Europe ku Baku mchaka cha 2015 nawonso adawonetsa kuyesa kogwiritsa ntchito meldonium, ndipo akatswiri adati panthawi yawo akuchita, pafupifupi 470 onse omwe adamwa mankhwalawo adatenga 17.
- Kuyambira nthawi imeneyi, geography yatukuka kwambiri, ndipo othamanga ku Russia, Ethiopia, Sweden, Germany ndi Ukraine agwidwa nthawi zosiyanasiyana pogwiritsa ntchito meldonium.
Zikuyenera 17% ya othamanga ku Russia amagwiritsa ntchito meldonium ndi 2% okha m'maiko ena. Ngati nambalayo ndi yolondola, ndiye kuti izi zikutsimikiza.
Nkhani yomwe yachitika posachedwa komanso kuletsa kutenga nawo mbali kwa magulu onse aku Russia ku Olimpiki kukuwonetsa kuti msika wa Russia, womwe umathandizira masewera aluso, ndi amodzi mwamphamvu kwambiri komanso otukuka padziko lapansi.
Mildronate adatchuka mu masewera makamaka chifukwa cha dzina la wosewera wa tennis waku Russia Maria Sharapova: atazindikira, kugulitsa mankhwalawa kunawonjezeka kangapo
Malinga ndi gulu la WADA, meldonium ndi ya gulu la metabolic modulators, kuphatikiza insulin 7.
Ngati mukuwona kuti ndizofunikira - tithandizire ntchito yathu!
Zowonjezera. Thupi limaphatikizidwa ndi pepala lolemba ngati:
- Amachita bwino masewera othamanga,
- Iwopseza othamanga,
- amaphwanya mzimu wopikisana.
Tanthauzo la chitsimikiziro choyamba ndikowonekera: othamanga omwe amamwa mankhwalawa amapeza zabwino kuposa ena. Chitsimikizo chachiwiri chimagwira ntchito pafupifupi mankhwala aliwonse azachipatala, chifukwa onse ali ndi mavuto. Koma tanthauzo la lachitatu ndilamphamvu kwambiri ndipo limakupatsani mwayi woletsa "kuletsa" chilichonse.
"Meldonium akuwonetsa kukonza osewera opirira, mitengo yobwezeretsa pambuyo pa kulipira, anti-nkhawa kuteteza ndi mantha dongosolo amathandizira. ”
Mndandanda wapadera wazotsatira za meldonium mu masewera ndi zina monga izi:
- zimawonjezera kuchita kwathunthu kwamthupi,
- Amapangitsa kuti mpweya uzitulutsa,
- imathandizira kusangalala kwa minyewa yamitsempha (izi ndizofunikira kuti kuthamanga kuzichite)
- imathandizira polimbana ndi kupsinjika kwa malingaliro pa mipikisano,
- Amathandizira pakupezeka kwa maselo a mtima ndi ubongo ndi glucose = mphamvu,
- imathandizira kuchotsedwa kwa zinthu zowonongeka.
Zotsatira za Mildronate, zomwe ndizofunikira kwa othamanga, ndikupititsa patsogolo kupezeka kwa mpweya ndi glucose ku minofu, kukulitsa kuchuluka kwa zomwe zimachitika komanso kuthana ndi nkhawa
Limagwirira zake meldonium
- Zotsatira zakuchiritsa kwa meldonium ndizo Kuletsa machitidwe a carnitine, yomwe imakhudzidwa ndi kagayidwe ka mafuta (kuwawotcha mphamvu), pakugwiritsa ntchito shuga 3.
- Mukamachita masewera olimbitsa thupi (omwe amawononga mpweya wambiri), L-carnitine imathandizira kugwira ntchito kwa mtima, ndikupanga mafuta oxidation ogwira ntchito mwamphamvu kwambiri: pafupifupi 80% ya mphamvu imapangidwa pogwiritsa ntchito makina 10 awa.
- Komabe, m'malo omwe mulibe okosijeni okwanira m'maselo, zinthu zapoizoni zimadziunjikira - zopangidwa ndi mafuta oxidation.
- Zomwe zimapangitsa meldonium: imalepheretsa makina a mafuta oxidation ndi carnitine (kuchepetsa kuchuluka kwake m'maselo) ndikuyambitsa kugwiritsa ntchito shuga, komwe ndiko gwero lamphamvu kwambiri komanso lothandiza kwambiri mthupi, popeza limafunikira mpweya wambiri 11-13 kuti uziphatikiza.
- Kuphatikiza apo, Mildronate imathandizira mwachindunji glycolysis, yomwe imakweza mphamvu za othamanga 14.
Kodi ndizomveka kuti titengere khungu (meldonium) pomanga thupi?
- Meldonium ndiyotchuka kwambiri m'masewera aerobic, mwachitsanzo, pakati pa osewera ndi othamanga omwe kuthamanga ndi kuchitapo kanthu ndikofunikira.
- Pankhani yogwiritsa ntchito kufatsa pomanga thupi ndikukhala mphamvu, Mosiyana ndi zomwe ambiri amakhulupirira, iye Sizimakhudza mwachindunji kukula kwa minofu.
- M'masewera agetsi imagwiritsidwa ntchito. kuchepetsa zizolowezi zobwereza, zomwe mwina ndizofunikira kwa akatswiri othamanga.
Werengani ife pa ukonde
Zomwe zili bwino: chepetsa katunduyo kapena onjezerani piritsi lina ku mankhwala anu opanga mankhwala - mwasankha.
Mildronate pomanga thupi sizimakhudza mwachangu kukula kwa minofu, amagwiritsidwa ntchito kuthana ndi zizindikiro zopitilira muyeso
Momwe mungatengere Mildronate othamanga: malangizo
Chizindikiro cha kutenga meldonium mumasewera ndi chikhalidwe chambiri chambiri.
M'maphunziro asayansi omwe amawonetsa zotsatira zabwino za kufewa kwa akatswiri othamanga, Mlingo wa 0.25-1 g kawiri pa tsiku nthawi zambiri amagwiritsidwa ntchito kwa masabata 2-3 a nthawi yophunzitsira, masiku 10 mpaka 14 mpikisano usanachitike.
Mukalandira kwambiri Mlingo woyenera ndi wofunikira. Mlingo watsiku ndi tsiku amawerengedwa potengera 15-20 mg pa kilogalamu ya thupi.
Meldonium pamasewera (ndi zomanga thupi) amavomerezedwa 1 nthawi patsiku 30 asanaphunzitsidwe.
Nditha kutenga Mildronate mpaka pati?
Kutalika kwa maphunzirowa ndi kuyambira pa masabata 6 mpaka miyezi itatu. Pambuyo pake, thupi limayamba kugwiritsa ntchito mankhwala osokoneza bongo, limatha mphamvu. Pambuyo pakupuma kwa milungu 4, chiwopsezo chimabwezeretseka.
Meldonium imatha kumwedwa m'mitundu iwiri: mapiritsi ndi jakisoni. Mwanjira ya mapiritsi, tsiku lililonse mlingo sayenera kupitirira 2 g. Zingwe ndizothandiza pafupifupi kawiri.
Mildronate nthawi zina amalimbikitsidwa pamodzi ndi L-carnitine ndi Riboxin. Poyambirira, pali kusamveka, popeza momwe limagwirira ntchito laofronite ndikutchingira zochita za carnitine.
Meldonium pamasewera ndi masewera olimbitsa thupi amatengedwa pamlingo wa 15-20 mg pa kg iliyonse ya thupi 1 nthawi isanaphunzitsidwe
Kodi meldonium imakhala nthawi yayitali bwanji?
- Palibe yankho losatsutsika pamafunso okhudzana ndi nthawi yochotsa meldonium m'thupi, chifukwa sipanaphunzitsidwe ndi asayansi.
- Olemba ena akuti nthawi yodzipatula nthawi yayitali Maola 24 ndi kumwa kamodzi, ngati atengedwa pafupipafupi, ndiye kuti kupezeka m'magazi kungatheke ngakhale pambuyo pake miyezi ingapo atasiya kugwiritsa ntchito.
- Akatswiri ena amati kuchotsedwa kwathunthu kwa kufalikira kwa thupi kumachitika m'masiku 100-120.
Nthawi yonse yochotsa meldonium m'thupi imatha kufika miyezi 3-4 ndikugwiritsa ntchito pafupipafupi
Mildronate: mavuto
Kafukufuku yemwe alipo palibe mavuto akulu meldonium.
Komabe, malinga ndi ndemanga za akatswiri a mtima, madokotala amawona kuti nkhaniyi siimamveka bwino.
Zotsatira zoyipa zimasonyezedwa mu malangizo ogwiritsira ntchito modekha:
- chifuwa
- tachycardia (kuchuluka kwa mtima),
- kugaya chakudya.
Pambuyo pake
Mildronate ndi chipangizo chamakampani opanga doping, omwe othamanga padziko lonse lapansi akufuna kuyesa (chifukwa cha Maria Sharapova pazomwezi).
Kugawana ndi kugwiritsa ntchito kothamanga kwa osewera ku Russia kukuwonetsa kuthekera kwake. Kafukufuku wochepa wa asayansi amatsimikizira kugwiritsa ntchito meldonium pamasewera aerobic (kuthamanga, ski, cycling) ndikuyimira pakati mu mphamvu (zomanga thupi, zopatsa mphamvu).
Mildronate amachotsedwa m'thupi kwa miyezi ingapo ndipo alibe zotsatira zoyipa.
Kugwiritsa ntchito mankhwalawa mankhwalawa mtima
Kwa anthu omwe ali ndi vuto la kuwonongeka kwa mtima, kuperewera kwa mtima, mankhwalawa amagwiritsidwa ntchito pokonzanso kagayidwe ka minofu ya mtima. Kuchuluka kwa mtima kwa Mildronate pochiza matenda a mtima ndi zotsatira za kugunda kwa mtima kumakhala ndi zotsatirazi:
- kuchuluka kwa kulekerera kwa mtima kutaya mtima,
- kutsitsa kwa dera la necrosis,
- kusintha kwa magazi m'dera lomwe lakhudzidwa,
- kuchepetsa kutalika kwa nthawi yokonzanso.
Odwala omwe ali ndi matenda a mtima osachiritsika, mankhwalawa amatha kuchepetsa pafupipafupi matenda a angina. Komanso, mankhwalawa, monga akuwunikira, amawonjezera mphamvu ya mtima ndi minyewa ya mtima. Pogwiritsa ntchito pafupipafupi, Mildronate amachepetsa kuchuluka kwa ma pathological omwe amapezeka myocardium.