Mapiritsi a Atoris: chimathandiza ndi chiyani mankhwalawa?

Atorvastatin ndi amodzi mwa mankhwala otsitsa lipid kuchokera pagulu la ma statins. Njira yayikulu yogwiritsira ntchito ndikulepheretsa ntchito ya HMG-CoA reductase (ma enzyme omwe amathandizira kusintha kwa HMG-CoA kukhala mevalonic acid). Kusintha uku ndi gawo limodzi mwamagawo oyambira kwambiri a cholesterol m'thupi. Pamene kaphatikizidwe ka Chs kakanikizika, pamakhalanso kuchuluka kwa ma LDL receptors (otsika kachulukidwe lipoproteins) m'chiwindi ndi minyewa yowonjezera. Pambuyo poti ma LDL amangidwa ndi ma receptor, amachotsedwa m'madzi a m'magazi, zimapangitsa kuchepa kwa ndende ya LDL-C m'magazi.

Mphamvu ya antiatherosulinotic ya atorvastatin imayamba chifukwa cha mphamvu yake pazinthu zamagazi ndi makoma amitsempha yamagazi. Atorvastatin linalake ndipo tikulephera kapangidwe ka isoprenoids, omwe ndi zinthu zomwe zimapanga kukula kwamitsempha yamagazi. Chifukwa cha momwe mankhwalawo amathandizira, pali kusintha pakubwera kotenga magazi kwa endothelium, kuchepa kwa ndende ya LDL-C, Apo-B (apolipoprotein B) ndi TG (triglycerides), kuwonjezeka kwa kuchuluka kwa HDL-C (high density lipoprotein) ndi Apo-A (apolipoprotein A).

The achire zotsatira za atorvastatin akuwonetseredwa mu kuchepa kwa magazi plasma mamasukidwe ndi ntchito zina za kupatsidwa zinthu za m'mwazi. Zotsatira zake, hemodynamics imayenda bwino ndipo mkhalidwe wa zophatikizika zimasinthasintha. HMG-CoA reductase inhibitors imakhudzanso kagayidwe ka macrophages, kutseka kutsegulira kwawo ndikuletsa kupasuka kwa zolembera za atherosulinotic.

Kukula kwa njira yochizira kumadziwika, monga lamulo, pambuyo pa milungu iwiri ya chithandizo, imafika pazokwanira zake mu masabata 4 ogwiritsa ntchito Atoris.

Pogwiritsa ntchito 80 mg ya Atoris patsiku, mwayi wa zovuta za ischemic (kuphatikizapo imfa yochokera m'matumbo am'matumbo) umachepetsedwa kwambiri 16%, ndipo chiopsezo chobwezerezedwanso chifukwa cha angina chotsatira ndi zizindikiro za myocardial ndi 26% yotsika.

Pharmacokinetics

Atorvastatin ali ndi mayamwidwe ambiri (pafupifupi 80% ya mankhwalawo amachokera mu thirakiti la m'mimba). Mlingo wa mayamwidwe ndi plasma ndende mu magazi ukuwonjezeka mogwirizana ndi mlingo. Nthawi yayitali kufikira C_max (kuchuluka kwa zinthu) - 1 mpaka 2 maola. Mwa akazi, chizindikiro ichi ndiwokwera 20%, ndipo AUC (dera lomwe lili pansi pajika "nthawi yokhazikika") ndi 10% yotsika. Mwa jenda ndi zaka, kusiyana kwa magawo a pharmacokinetic ndizochepa ndipo kusintha kwa mankhwala sikofunikira.

Ndi zakumwa zoledzeretsa za chiwindi T_max (nthawi yofika pozindikira kwambiri) ndi 16 poyerekeza ndi masiku onse. Kudya pang'ono kumachepetsa nthawi komanso kuchuluka kwa mayamwidwe a atorvastatin (ndi 9% ndi 25%, motsatana), pomwe kuchepa kwa ndende ya LDL-C kuli kofanana ndi kwa Atoris wopanda chakudya.

Atorvastatin ali ndi bioavailability wotsika kwambiri (12%), dongosolo la bioavailability la inhibitory zochita motsutsana ndi HMG-CoA reductase ndi 30% (chifukwa cha kagayidwe kamomwe kamayendetsa mucous membrane wam'mimba komanso kuthamanga kwa "gawo loyambira" kudzera m'chiwindi.

V_d (voliyumu) ya atorvastatin pafupifupi 381 malita. Zoposa 98% za zinthu zomwe zimamangidwa ndi mapuloteni a plasma. Atorvastatin simalowa mu zotchinga magazi-ubongo. Metabolism imachitika makamaka mothandizidwa ndi isoenzyme CYP3A4 cytochrome P₄₅₀ mu chiwindi. Zotsatira zake, metabolite yogwira metabolac imapangidwa (para- ndi orthohydroxylated metabolites, zinthu za beta-oxidation), zomwe zimapangitsa pafupifupi 70% ya zochita zoletsa motsutsana ndi HMG-CoA reductase kwa maola 20-30.

T_1/2 (theka-moyo) la atorvastatin ndi maola 14. Amachotseredwa makamaka ndi bile (kutchulidwa kuti matumbo amadzimatirana samawululidwa, ndi hemodialysis sichinafotokozedwe). Pafupifupi 46% ya atorvastatin imachotsedwa m'matumbo, osakwana 2% ndi impso.

Ndi chidakwa cha chiwindi (monga gulu la ana-Pugh - gulu B), kuchuluka kwa atorvastatin kumawonjezeka kwambiri (C_max - nthawi 16, AUC - pafupifupi nthawi 11).

Contraindication

mimba
kuyamwa
osakwana zaka 18
matenda a chiwindi (hepatitis yayikulu, cirrhosis, chiwindi),
chotupa minofu matenda
lactose tsankho, kufupika kwa lactase, galactose / glucose malabsorption syndrome,
Hypersensitivity pamagawo a mankhwala.

Malinga ndi malangizo, Atoris ayenera kuikidwa mosamala vuto la matenda a chiwindi m'mbiri komanso kudalira mowa.

Malangizo ogwiritsira ntchito Atoris: njira ndi mlingo

Mapiritsi a Atoris amatengedwa pakamwa nthawi imodzi, mosasamala zakudya.

Zakudya zisanachitike komanso munthawi yamankhwala, zakudya zomwe zimakhala ndi lipid zochepa ziyenera kutsatiridwa.

Atoris sagwiritsidwa ntchito ngati ana, odwala akuluakulu amawerengera 10 mg kamodzi patsiku kwa masabata anayi. Ngati achire zotsatira pambuyo koyamba maphunziro si anati, zochokera lipid mbiri, tsiku lililonse mlingo ukuwonjezeka mpaka 20-80 mg patsiku.

Zotsatira zoyipa

Kugwiritsa ntchito Atoris kumatha kuyambitsa zovuta zingapo:

Kuchokera kumimba: kuponderezana chopondera, nseru, kuchepa kwa chakudya, kapamba, kuchepa kwa ndulu, kusanza, hepatitis, kupweteka kwa epigastric dera, flatulence,
Kuchokera kwamanjenje: chizungulire, paresthesia, kusokonezeka kwa kudzutsidwa komanso kugona machitidwe, zotumphukira zamitsempha, mutu,
Kuchokera kwamankhwala am'mimba: kukokana, kufooka kwa minofu, myopathy, kupweteka kwa minofu, myositis,
Kuchokera pamtima dongosolo: arrhythmia, palpitations, phlebitis, vasodilation, kuchuluka kwa magazi,
thupi lawo siligwirizana: alopecia, urticaria, kuyabwa, zotupa pakhungu, edema ya Quincke.

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandiza Atoris ndi chiyani? Lembani mankhwalawa mu milandu iyi:

zochizira odwala pulayimale (mtundu 2a ndi 2b) ndi hyperlipidemia yosakanikirana.
makonzedwe a mankhwala akusonyeza odwala homozygous hypercholesterolemia ndi kuchuluka: cholesterol ambiri, otsika kachulukidwe lipoprotein cholesterol, triglyceride kapena apolipoprotein B

Malangizo ogwiritsira ntchito Atoris, mlingo

Mankhwala amatengedwa pakamwa, ngakhale chakudyacho.

Mlingo woyamba wa piritsi la Atoris 10 mg tsiku lililonse. Malinga ndi malangizo, mlingo wa mankhwalawa umasiyana 10 mg mpaka 80 mg kamodzi patsiku, ndipo umasankhidwa poganizira kuchuluka koyamba kwa LDL-C, cholinga cha mankhwala ndi chithandizo cha munthu. Mlingo weniweni wa mankhwalawa amasankhidwa ndi adotolo, poganizira zotsatira za mayeso ndi kuchuluka koyamba kwa cholesterol.

Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo, ndikofunikira kuyang'anira zamasamba a plasma masabata onse a 2-4 ndikusintha mlingo moyenerera.

Mu pulayimale (heterozygous hereditary and polygenic) hypercholesterolemia (mtundu IIa) ndi hyperlipidemia wosakanikirana (mtundu IIb), chithandizo chimayamba ndi mlingo woyambirira, womwe umachulukitsidwa pambuyo pa masabata 4 kutengera momwe wodwalayo amayankhira. Mlingo wapamwamba tsiku lililonse ndi 80 mg.

Kwa okalamba ndi odwala omwe ali ndi vuto laimpso, kusintha kwa mankhwalawa sikofunikira.

Odwala omwe ali ndi vuto la chiwindi, mankhwala amaperekedwa mosamala pokhudzana ndi kutsika kwa mankhwalawa.

Zotsatira zoyipa

Malinga ndi malangizo ogwiritsira ntchito, kuikidwa kwa Atoris kungakhale ndi zotsatirazi:

Kuchokera ku psyche: kukhumudwa, kusokonezeka kwa kugona, kuphatikizapo kusowa tulo komanso zolakwika.
Kuchokera ku chitetezo chathupi: thupi lawo siligwirizana, anaphylaxis (kuphatikizapo anaphylactic mantha).
Matenda a metabolism: hyperglycemia, hypoglycemia, kulemera, anorexia, shuga mellitus.
Kuchokera pakubala ndi tiziwitsi tambiri: kutomoka, kugona, gynecomastia.
Kuchokera kwamanjenje: mutu, paresthesia, chizungulire, Hypesthesia, dysgeusia, amnesia, zotumphukira neuropathy.
Kuchokera kupuma dongosolo: interstitial m'mapapo matenda, zilonda zapakhosi ndi mphuno, nosebleeds.
Zofooka ndi zofikisa: nasopharyngitis, matenda amkodzo.
Kuchokera pamagazi ndi dongosolo la lymphatic: thrombocytopenia.
Kuchokera kumbali ya gawo la masomphenyawo: Kuwona bwino, kuwona kuwonongeka.
Kuchokera pamtima dongosolo: sitiroko.
Mbali ya chiwalo chothandizira kumva: tinnitus, kumva kusamva.
Kuchokera mmimba thirakiti: kudzimbidwa, kugonthetsa, kukanika, kuphwanya, kutsegula m'mimba, kusanza, kupweteka pamimba ndi m'munsi pamimba, kupindika, kapamba.
Kuchokera ku hepatobiliary system: hepatitis, cholestasis, kulephera kwa chiwindi.
Pa khungu ndi subcutaneous zimakhala: urticaria, zotupa pakhungu, kuyabwa, alopecia, angioedema, oxerm dermatitis, kuphatikizapo exudative erythema, Stevens-Johnson syndrome, poyizoni epermermal necrolysis, kupindika kwa tendon.
Kuchokera ku minculoskeletal system: myalgia, arthralgia, kupweteka kwa miyendo, kukokana kwa minofu, kutupa kwapakati, kupweteka kumbuyo, kupweteka kwa khosi, kufooka kwa minofu, myopathy, myositis, rhabdomyolysis, tendonopathy (nthawi zina kuphatikizidwa ndi kupindika kwa tendon).
Mavuto wamba: malaise, asthenia, kupweteka pachifuwa, zotupa zakupsa, kutopa, kutentha thupi.

Contraindication

Atoris amatsutsana pamilandu yotsatirayi:

tsankho limodzi ndi zigawo za mankhwala,
galactosemia,
malabsorption wa shuga galactose,
kufupika kwa lactose,
matenda a impso,
mafupa amisempha
mimba
yoyamwitsa
zaka mpaka 10.

Chenjezo liyenera kumwedwa ndi uchidakwa, matenda a chiwindi. Gululi limaphatikizaponso anthu omwe ntchito zawo zimakhala zokhudzana ndi kuyendetsa magalimoto ndi magwiridwe antchito.

Bongo

Pankhani ya bongo, mankhwala othandiza komanso othandizira ayenera kuchitika. Ndikofunikira kuwongolera ntchito ya chiwindi ndi ntchito za CPK mu seramu yamagazi. Hemodialysis siyothandiza. Palibe mankhwala enieni.

Ma analogi a Atoris, mtengo pama pharmacies

Ngati ndi kotheka, Atoris ikhoza kulowa m'malo mwa analogue ya yogwira - awa ndi mankhwala:

Posankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Atoris, mtengo ndi kuwunika kwa mankhwala omwe ali ndi zotsatira zofananira sizikugwira ntchito. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mtengo muma Russian pharmacies: Atoris mapiritsi 10 mg 30 ma PC. - kuchokera ku 337 mpaka 394 rubles, 20 mg 30pcs - kuchokera 474 mpaka 503 rubles.

Sungani ku kutentha kosaposa 25 ° C. Moyo wa alumali ndi zaka 2. M'mafakisi, amagulitsidwa ndi mankhwala.

Pali ndemanga zosiyanasiyana za Atoris, monga ambiri amanenera kuti mtengo wokwera wa mankhwalawo umavomerezeka chifukwa chogwira ntchito komanso kulolera bwino. Dziwani kuti mukamalandira chithandizo, malangizo a dokotala okhudzana ndi kadyedwe komanso zolimbitsa thupi ayenera kutsatiridwa, ndipo posankha ndikusintha mankhwalawa, kugwiritsidwa ntchito kwa lipoprotein kochepa kwambiri kuyenera kukumbukiridwa. Malinga ndi ogwiritsa ntchito ena, mankhwalawa alibe mphamvu yothandizirana ndipo samatha kulekerera, zomwe zimapangitsa kuti anthu azidzakumana ndi zovuta.

Ndemanga zisanu za "Atoris"

bambo anga akhala akutenga atoris kwa zaka ziwiri popanda kupuma atachitidwa opaleshoni ya mtima - alibe mavuto, chilichonse chimakhala payekha

Mankhwalawa ndi odabwitsa, osakhala ndi zotsatira zoyipa. Cholesterol yanga inali 6.2-6.7.
Ndimakonda kumwa Atoris ndi 20 mg. Tsopano cholesterol ndiyokhazikika kuyambira 3.5 mpaka 3.9. Sinditsatira zakudya.

Mthandizi wabwino pakuthana ndi mavuto, ngakhale osakhala ndi zotsutsana paliponse, koma cholesterol iyenera kuyang'aniridwa.

Ndimamwa Atoris milungu iwiri ngati nkotheka kupuma.

Adandipatsa mankhwala chifukwa cha ED. Ndimalola tsiku lililonse, ndipita kukayezetsa posachedwa. Pazokonzanso, ndikutenga Sildenafil-SZ.

Kodi mapiritsi a Atoris amathandiza ndi chiyani? - zikuwonetsa

Atoris akuwonetsa chifukwa cha matenda ambiri a mtima wamatsenga ndi zovuta zomwe zimayenderana:

hypercholesterolemia,
Hyperlipidemia,
dyslipidemia, kuti muchepetse chiopsezo cha myocardial infarction,
mawonekedwe owopsa a matenda a mtima a ischemic,
sitiroko
kupezeka kwa angina pectoris.

Mankhwalawa amagwiritsidwanso ntchito moyenera pa zovuta monga matenda a shuga mellitus, hyperlipidemia.

Atoris analogues, mndandanda wa mankhwala

Atoris analogues ndi awa:

Zofunikira - malangizo ogwiritsira ntchito Atoris, mtengo ndi kuwunika sizigwira ntchito pa analogues ndipo sizingagwiritsidwe ntchito ngati chiwongolero chogwiritsa ntchito mankhwala omwe ali ndi kapangidwe kake kapena kagwiritsidwe. Nthawi zonse zochizira ziyenera kupangidwa ndi dokotala. Mukasinthitsa Atoris ndi analogue, ndikofunikira kufunsa katswiri, mungafunike kusintha njira zamankhwala, mankhwalawa, etc. Osadziletsa!

Ndemanga za madotolo pakugwiritsa ntchito Atoris ndizabwino kwenikweni - odwala amawona kusintha kwawumoyo wawo kwakanthawi, ngakhale atachira mankhwalawo. Mankhwalawa ndi othandizira kutsitsa lipid ndipo amayenera kumwedwa pokhapokha ngati akuwuzidwa ndi dokotala.

Kutulutsa mawonekedwe ndi kapangidwe kake

Atoris amapangidwa ku Slovenia monga mapiritsi okhala ndi chipolopolo chomwe chimayenera kutengedwa pakamwa. Mlingo wa Atoris 10, 20, 30 ndi 40 mg ndi zoyera komanso zoyera (mawonekedwe okumbikawo ndiwofanana ndi mankhwala a 60 ndi 80 mg, omwe samapezeka pamsika waku Russia).

M'mapaketi a 30 kapena 90 Mlingo, komanso malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Atorvastatin (dzina lapadziko lonse - Atorvastatin) ndiye chinthu chachikulu chothandizira pa mankhwala Atoris (INN mu Latin - Atoris). Kuwonekera konse kwa zamankhwala kumapangitsa kuti zochita za Atorvastatin zichitike mosiyanasiyana - 10, 20, 30, 40 mg (Mlingo wa Atoris 60 ndi 80 mg adalembetsedwa m'maiko ena).

Makhalidwe

Atoris amathandizira popereka zoterezi chifukwa chamatsenga:

Amathandizira kuchepetsa kukhuthala kwa magazi, amatulutsa njira ya magazi.
Zimathandizira kupewa kutumphuka kwa malo a atherosulinotic.
Amachepetsa cholesterol-otsika kachulukidwe lipoproteins, triglycerides.
Kuchulukitsa zomwe zimakhala ndi kachulukidwe kakakulu ka lipoprotein cholesterol.
Ili ndi anti-atherosulinotic zotsatira - imakhudza bwino makoma amitsempha yamagazi.

The achire zotsatira za Atoris amakula pambuyo 2 milungu kudya pafupipafupi mapiritsi, pazotheka zotsatira za mankhwala - 1 mwezi.

Kodi Atoris amatchulidwa kuti?

Mankhwala amathandizira pazinthu zotsatirazi:

Zizindikiro zogwiritsidwa ntchito ndi Atoris zimasiyana pang'ono kutengera ndi kuchuluka kwa mapiritsi a atorvastatin.

Atoris 10 mg ndi Atoris 20 mg:

hyperlipidemia yoyamba ya mitundu IIa ndi IIb malinga ndi gulu la Fredrickson, kuphatikiza polygenic hypercholesterolemia, hyperlipidemia, heterozygous Famial hypercholesterolemia, kuti muchepetse cholesterol, apolipoprotein B, LDL cholesterol, triglycerides m'magazi,
banja homozygous hypercholesterolemia, pakuchepetsa kolesterol yonse, apolipoprotein B, LDL cholesterol, kuwonjezera pa zakudya mankhwala ndi njira zina zosagwiritsa ntchito mankhwala.

Atoris 30, 40, 60, 80 mg:

hypercholesterolemia yoyamba (yosakhala ya banja komanso ya heterozygous mtundu II hypercholesterolemia malinga ndi gulu la Fredrickson,
Hyperlipidemia yosakanikirana ya mitundu IIa ndi IIb malinga ndi gulu la Fredrickson,
lembani III dysbetalipoproteinemia malinga ndi gulu la Fredrickson (monga njira yothandizira pakudya),
zakudya zosagwirizana ndi mtundu wina wa IV mtundu wa hypertriglyceridemia malinga ndi gulu la Fredrickson,
mabanja homozygous hypercholesterolemia, kuwonjezera pa zakudya mankhwala ndi njira zina zosagwiritsa ntchito mankhwala.

Mlingo onse wa Atoris amalembedwa:

pa cholinga choyesa kupewa matenda a mtima mu odwala popanda kuwonetsa IHD, koma ndi kuthekera kwa chitukuko chake chifukwa cha zinthu zomwe zachitika, kuphatikizapo zaka zapakati pa zaka 55, matenda oopsa, kuchepa kwa chikumbumtima, matenda a shuga, kuchepa kwamafuta a m'magazi a HDL ,
ndi cholinga chachiwiri kupewa mtima wamtima odwala omwe ali ndi matenda a mtima, kuchepetsa mavuto, kuphatikizira kulowetsedwa kwamtima, kufa, sitiroko, kuyambiranso kuchipatala komwe kumayenderana ndi angina pectoris ndi kufunika kosinthanso.

Malangizo azachipatala ogwiritsira ntchito

Mukamamwa Atoris, wodwalayo ayenera kutsatira mfundo zazikulu za zakudya zomwe zimachepetsa lipid panthawi yonse ya chithandizo.

Odwala onenepa amalangizidwa izi: Asanayambe kugwiritsa ntchito Atoris, munthu ayenera kuyesa kusintha matenda a cholesterol polimbana ndi kuyesetsa kwakuthupi komanso chithandizo cha zomwe zimayambitsa matendawa.

Ndimatenga Atoris mkati, mosasamala kanthu za chakudya. Mlingo woyambayo ndi 10 mg.

Pakufunika, mlingo utha kuwonjezeka mpaka 80 mg. Mlingo weniweni wa mankhwalawa amasankhidwa ndi adotolo, poganizira zotsatira za mayeso ndi kuchuluka koyamba kwa cholesterol.

Tsiku lililonse limodzi la mankhwala akulimbikitsidwa, makamaka nthawi yomweyo. Mlingo sayenera kusinthidwa kale kuposa mwezi umodzi atatha kugwiritsa ntchito mankhwalawa.

Pa chithandizo, ndikofunikira kuwunika pafupipafupi kuchuluka kwa lipids m'madzi a m'magazi. Ndondomeko ziyenera kuchitidwa kamodzi pakadutsa masabata a 2-4.

Kusintha kwa Mlingo kwa odwala azaka zaukalamba sikofunikira.

Atoris imagwiritsidwa ntchito ngati chothandizira pakuthandizira limodzi ndi njira zina zochizira (plasmapheresis). Mankhwalawa atha kugwiritsidwanso ntchito ngati gawo lalikulu la mankhwalawa ngati njira zina zochiritsira komanso mankhwala zilibe chithandizo.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Atoris amatsutsana mwa amayi apakati komanso oyamwa.

Mankhwalawa amalembera azimayi azaka zakubadwa pokhapokha ngati mwayi wokhala ndi pakati ndi wochepa kwambiri, ndipo wodwalayo akudziwitsidwa za chiopsezo cha mwana wosabadwayo. Amayi a msinkhu wobereka ayenera kugwiritsa ntchito njira zokwanira zolerera panthawi ya chithandizo. Ngati mayi akukonzekera kutenga pakati, ayenera kusiya kumwa Atoris osachepera mwezi asanakonzekere kutenga pakati.

Ngati ndi kotheka, kuikidwa kwa Atoris ndi chisankho chothetsa kuyamwitsa.

Kutenga ana?

Kafukufuku wokhudzana ndi luso la Atoris komanso chitetezo chogwiritsira ntchito kwa ana sichinachitike, komwe mapiritsi a Atoris adatsutsana mpaka zaka 18 zakubadwa.

Anvistat
Atocord
Atomax
Atorvastatin
Calcium wa atorvastatin,
Atorvox
Vazator
Lipona
Lipoford
Liprimar
Liptonorm,
TG-tor
Torvazin
Torvacard
Tulip.

Mukamasankha analogi, muyenera kukumbukira kuti malangizo ogwiritsira ntchito Atoris, mtengo ndi kuwunika kwa mankhwalawa sikugwira ntchito. Kusintha kwa mankhwalawo ndikovomerezeka pokhapokha akutsimikiziridwa ndi dokotala.

Liprimar kapena Atoris - ndibwino?

Monga momwe zinaliri ndi Torvacard, Liprimar ndi lingaliro lofanana la Atoris, ndiye kuti, lili ndi zinthu zofanana ndi atorvastatin monga chogwiritsa ntchito. Mankhwala onsewa ali ndi zofanana, mawonekedwe ogwiritsira ntchito, contraindication, mavuto, etc.

Mlingo wa Liprimar ubwereza Mlingo wa Atoris kupatula mapiritsi 30 mg. Makampani opanga makampani Liprimara - Pfizer (Ireland), omwe pawokha amalankhula za mtundu wapamwamba kwambiri wa chinthucho.

Ndizofunikira kudziwa kuti Liprimar ndiye mankhwala oyamba a atorvastatin, ndipo ena onse, kuphatikizapo Atoris, ndizomwe amapanga.

Torvakard kapena Atoris - ndibwino?

Tiyenera kudziwa kuti mankhwalawa onse ali ndi atorvastatin monga mankhwala othandizira, chifukwa chake ali ndi zotsatira zomwezi zamankhwala. Atoris amapangidwa ndi Krka (Slovenia), ndi Torvacard wolemba Zentiva (Czech Republic).

Makampani onse opanga ndi otchuka komanso ali ndi mbiri yabwino, zomwe zimapangitsa kuti mankhwalawa akhale opanda chidwi. Kusiyana pakati pa Torvacard ndi kuchuluka kwa mapiritsi ake, omwe ndi okwanira 40 mg, pomwe zina zofunikira za paticvastatin 80 mg, zomwe zingayambitse zovuta zina za mapiritsi.

Malangizo apadera

Asanayambe mankhwala a Atoris, wodwalayo ayenera kutsegulidwa zakudya zomwe azitsatira panthawi yonse ya chithandizo.

Mukamagwiritsa ntchito Atoris, kuwonjezeka kwa ntchito ya hepatic transaminase kungadziwike. Kuchulukaku nthawi zambiri kumakhala kocheperako ndipo sikutanthauza kufunikira kwamankhwala. Komabe, ndikofunikira kuyang'anitsitsa pafupipafupi mawonekedwe a chiwindi ntchito musanalandire chithandizo, masabata 6 ndi masabata 12 atatha kumwa mankhwalawa ndikukula kwa mlingo. Kuchiza kuyenera kusiyidwa ndi kuwonjezeka kwa AST ndi ALT koposa 3 nthawi zokhudzana ndi VGN.

Atorvastatin ikhoza kuyambitsa kuwonjezeka kwa zochitika za CPK ndi aminotransferases.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala nthawi yomweyo ngati ululu wosamveka kapena kufooka kwa minofu kumachitika. Makamaka ngati zizindikirozi zimatsagana ndi malaise ndi kutentha thupi.

Ndi chithandizo ndi Atoris, kukula kwa myopathy ndikotheka, komwe nthawi zina kumayendetsedwa ndi rhabdomyolysis, zomwe zimayambitsa kulephera kwa impso. Kuopsa kwa vutoli kumakulirakudya ndikumamwa kamodzi kapena zingapo mwa mankhwalawa ndi Atoris: ma fibrate, nicotinic acid, cyclosporine, nefazodone, maantibayotiki ena, azole antifungals, ndi HIV proteinase inhibitors.

Mu mawonetseredwe azachipatala a myopathy, tikulimbikitsidwa kuti plasma wozama wa CPK utsimikizike. Ndi kuwonjezeka kwa 10 kwa ntchito ya VGN ya KFK, chithandizo ndi Atoris ziyenera kusiyidwa.

Pali malipoti a kakulidwe ka atonic fasciitis ndi kugwiritsa ntchito atorvastatin, komabe, kulumikizana ndi kugwiritsa ntchito mankhwalawa ndizotheka, koma sikunatsimikizidwe, etiology sichikudziwika.

Bongo

Palibe umboni wa bongo.

Pankhani ya bongo, mankhwala othandizira ndi a dalili amasonyezedwa. Kuwunika ndi kusamalira zofunikira za thupi, kupewa kuyamwa kwa Atoris (kumwa mankhwala osokoneza bongo kapena mankhwala othandizira, ma gastric lavage), kuyang'anira ntchito ya chiwindi ndi ntchito ya creatine phosphokinase mu seramu yamagazi amafunikira.

Hemodialysis siyothandiza. Palibe mankhwala enieni.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo kugwiritsa ntchito Atoris (10 mg) ndi diltiazem (200 mg), kuwonjezeka kwa ndende ya Atoris m'madzi a m'magazi kungaoneke.

Chiwopsezo cha zovuta zimawonjezeka pamene Atoris imagwiritsidwa ntchito molumikizana ndi fibrate, nicotinic acid, maantibayotiki, othandizira antifungal.

Kuchita bwino kwa Atoris kumachepa ndi kugwiritsa ntchito pamodzi kwa Rifampicin ndi Phenytoin.

Pogwiritsa ntchito imodzi ndi antacid kukonzekera, omwe akuphatikizapo aluminiyamu ndi magnesium, kuchepa kwa ndende ya Atoris m'madzi a m'magazi kumawonedwa.

Kutenga Atoris limodzi ndi madzi a mphesa kumatha kuwonjezera kuchuluka kwa mankhwalawa m'madzi a m'magazi. Odwala omwe amatenga Atoris ayenera kukumbukira kuti kumwa madzi a mphesa m'milingo yoposa 1 lita imodzi sikuvomerezeka.

Kodi ndemanga zikuyankhula chiyani?

Malinga ndi ogwiritsa ntchito ena, mankhwalawa alibe mphamvu yothandizirana ndipo samatha kulekerera, zomwe zimapangitsa kuti anthu azidzakumana ndi zovuta.

Ndemanga za Atoris

Pali ndemanga zosiyanasiyana za Atoris. Ambiri amazindikira kuti mtengo wokwera wa mankhwalawo umavomerezeka chifukwa chogwira ntchito komanso kulolera bwino. Dziwani kuti mukamalandira chithandizo, malangizo a dokotala okhudzana ndi kadyedwe komanso zolimbitsa thupi ayenera kutsatiridwa, ndipo posankha ndikusintha mankhwalawa, kugwiritsidwa ntchito kwa lipoprotein kochepa kwambiri kuyenera kukumbukiridwa. Malinga ndi ogwiritsa ntchito ena, Atoris alibe njira yothandizirana ndipo sagwirizana kwenikweni, zomwe zimapangitsa kuti pakhale zovuta zina.

Kodi mankhwalawa amagwira ntchito bwanji?

Pamaziko a yogwira a atorvastatin, mankhwala Atoris anapangidwa. Kodi chimathandiza ndi chiyani? Amachepetsa kuchuluka kwa lipids m'magazi. Chifukwa cha zochita za atorvastatin, ntchito ya GMA reductase yafupika ndipo kapangidwe ka cholesterol koletsedwa. Kuchulukitsa kwa zotsirizika mu plasma kumachepetsedwa kwambiri chifukwa cha kuchuluka kwa zolandilira pama cell a chiwindi komanso kuwonjezeka kwa kumangiriza kwa lipoproteins.

"Atoris" imakhudzanso mitsempha yamagazi. The yogwira mankhwala linalake ndipo tikulephera kupanga isoprenoids. Vasodilation imakhalanso bwino. Monga lamulo, zotsatira zoyambirira zimatha kuchitika pakatha milungu iwiri. Ndipo pakatha milungu inayi, kuchuluka kwake kumachitika.

Pafupifupi 80% yazinthu zomwe zimagwira ntchito zimalowetsedwa m'mimba. Pambuyo 2 maola, ndende ya atorvastatin mthupi limafika pachimake chizindikiritso. Ndizofunikira kudziwa kuti mwa akazi chiwerengerochi ndi 20% kuposa amuna. Ntchito ya inhibitory imatha mpaka maola 30. Koma kuthetsedwa kwa mankhwalawa kumayamba pakatha maola 14. Gawo lalikulu limapukusidwa mu bile. 40-46% yotsala imachoka m'thupi kudzera m'matumbo ndi urethra.

Mwambiri, madokotala amasankha kukhazikitsa mankhwala ngati Atoris. Zizindikiro pakugwiritsa ntchito motere:

hypercholesterolemia yoyamba,
Hyperlipidemia
m'mabanja hypercholesterolemia,
dysbetalipoproteinemia,
mtima ndi mtima matenda oyambitsidwa ndi dyslipidemia,
kupewa matenda a mtima, matenda a mtima ndi angina pectoris,
kupewa yachiwiri chifukwa cha matenda a mtima.

Kuphwanya kwakukulu

Si odwala onse omwe amatha kugwiritsa ntchito mapiritsi a Atoris. Contraindication ndi motere:

matenda osachiritsika a chiwindi omwe ali pakulipa kwambiri.
chidakwa hepatitis
kulephera kwa chiwindi
mimba ndi kuyamwitsa,
matenda a chiwindi
kuchuluka kwa hepatic transaminases,
kudziwa gawo la yogwira kapena siligwirizana nalo,
matenda a minofu
wazaka 18
lactase tsankho kapena kuchepa kwake,
matenda a impso
galactose malabsorption.

Mosamala kwambiri, mankhwalawa amaperekedwa kwa odwala omwe ali ndi matenda:

uchidakwa
kuvuta kwambiri pakompyuta,
mavuto a metabolic
matenda endocrine
kuthamanga kwa magazi
matenda opatsirana opatsirana
khunyu
chithandizo chachikulu cha opaleshoni,
kuvulala kwambiri.

Momwe mungamwe mankhwalawa

Kuti mukwaniritse tanthauzo lotchulidwa, ndikofunikira kutenga "Atoris" molondola. Malangizowa ali ndi izi:

Masiku angapo asanayambe kumwa mankhwalawa, wodwalayo ayenera kusinthidwa kuti adye, zomwe zikutanthauza kuchepa kwa lipids. Zakudya izi zimayenera kutsatira nthawi yonse ya chithandizo.
Mapiritsi a Atoris amatengedwa mosasamala nthawi yakudya.
Kutengera ndende yoyamba ya LDL-C yotsimikizika ndi zotsatira za kusanthula, 10-80 mg ya mankhwala patsiku imatha kutumikiridwa. Kuchuluka kumeneku kumagwiritsidwa ntchito nthawi imodzi.
Ndikulimbikitsidwa kugwiritsa ntchito mankhwala "Atoris" tsiku lililonse nthawi yomweyo.
Kusintha kwa mankhwalawa sikulimbikitsidwa kale kuposa masabata anayi atayamba mankhwalawa. Pambuyo pokhapokha ngati titha kuona momwe achire amathandizira ndikusintha mankhwalawo.

Kutalika Kovomerezeka

Kuchokera kwa odwala mumatha kumva malingaliro osiyanasiyana kuti atenge Atoris nthawi yayitali bwanji. Akatswiri amati ngati pali chiopsezo cha matenda a mtima, ndiye kuti mankhwalawo amayenera kumwedwa nthawi zonse (ndiye kuti, moyo wonse). Nthawi yomweyo, sikulimbikitsidwa kuti mupumule nthawi iliyonse, chifukwa mankhwalawa atorvastatin samapangidwira makonzedwe a maphunziro. Ngakhale atakhala ndi zovuta mthupi chifukwa chokhala ndi thanzi, muyenera kusankha pakati pa moyo wabwino ndi chiyembekezo. Kuchepetsa mulingo kapena kuchotsedwa ndizotheka pokhapokha ngati zovuta zina sizipirira.

Odwala ena amachita machitachita amateur ndipo amamwa mankhwala atorvastatin tsiku lililonse tsiku lililonse. Izi sizitchedwa "zaluso chabe". Ngati dokotala akukulangizani izi, ndi bwino kukayikira luso lakelo. Palibe maphunziro azachipatala omwe angatsimikizire kuyenda bwino kwa kayendetsedwe kamankhwala ngati kameneka komwe kachitidwa.

Mankhwala a Atoris: mavuto

Ngakhale zabwino zonse zomwe mankhwalawo amafunsidwa, nthawi zina pamakhala kuwonongeka muumoyo. Chifukwa chake, kuyang'aniridwa ndi dokotala, ndikofunikira kuti atenge Atoris. Zotsatira zoyipa zingakhale motere:

Nthawi zina manjenjenje amayamba kumwa mankhwalawa ndi kusowa tulo komanso chizungulire. Asthenia, kupweteka mutu komanso kusokonezeka kwa malingaliro ndizothekanso. Kawirikawiri kugona, kukumbukira kukumbukira, kukhumudwa ndi kukhumudwa kumachitika.
Zotsatira zoyipa zimatha kuchitika kuchokera ku ziwalo zamagetsi. Tinnitus ndi kumva pang'ono kwa makutu, maso owuma, malingaliro olakwika a kukoma, kapena kuwonongeka kwathunthu kwa zomverera nthawi zina zimadziwika.
Atoris imatha kuyambitsa mavuto ndi mtima. Ndemanga za odwala zimakhala ndi zambiri zokhudzana ndi kupweteka pachifuwa, kukhumudwa kwa mtima, kuthamanga kwa magazi, arrhythmias, angina pectoris. Matendawa ndizotheka.
Mukamamwa mankhwalawa, kupuma komwe kumakhala kosavuta. Mankhwalawa amatha kuyambitsa chibayo, matenda a chifuwa, mphumu. Ma nosebleeds omwe amapezeka pafupipafupi nawonso atha.
Zotsatira zoyipa zambiri zimawonedwa kuchokera m'mimba. Odwala nthawi zambiri amafotokoza kupweteka kwam'mimba komanso m'mimba, nseru, kutsegula m'mimba, kusefukira. Mankhwala amatha kuyambitsa chidwi chachikulu kapena kusakhalapo. Mwina mapangidwe a zilonda zam'mimba, gastritis, kapamba. Nthawi zina, magazi amakulu amadziwika.
Ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, mavuto omwe ali ndi minofu ya mafupa akhoza kuchitika. Nthawi zambiri, odwala ripoti kukokana, myositis, nyamakazi ndi minofu hypertonicity.
Dongosolo la genitourinary limawonjezera chiopsezo cha matenda opatsirana, mavuto ndi kukodza (kuchepa kapena enursis), nephritis, matenda opatsirana pogonana, kutuluka magazi mu ukazi.
Odwala omwe amatenga mapiritsi a Atoris nthawi yayitali amawona kuchepa kwa tsitsi ndikukula thukuta. Zotheka kukhala ndi zotsatira zoyipa pakhungu pakhungu, totupa, urticaria.Osadziwika kwambiri ndi kutupa kwa nkhope.
Ngakhale mukumwa mankhwalawa, kuwonjezeka pang'ono kwa thupi kumatha.

Mankhwala "Atoris": analogues

Mankhwala omwe amafunsidwawa ali ndi malo enaake omwe amathandizanso thupi. Kutengera ndi wopanga, mtengo wake ukhoza kukhala wapamwamba kapena wotsika kuposa Atoris. Zofanizira ndi izi:

"Torvacard" - monga mankhwala omwe amafunsidwa, ali ndi zinthu monga atorvastatin. Ngakhale kuti ili pafupifupi analogue yathunthu, kuwongolera kwake kwa kayendetsedwe kake kumakhala kwakukulu. Koma zimawononga pafupifupi katatu katatu kuposa chida chomwe chafunsidwa.
Liprimar ndi chithunzi chonse cha Atoris. Izi zitha kuwoneka osati pakupanga mankhwala, komanso mu zikuwonetsa, contraindication ndi matenda.
"Woyimba" - ndi mndandanda wathunthu wa mankhwalawo womwe ukufunsidwa. Popeza palibe maphunziro omwe adachitidwa zokhudzana ndi chitetezo cha ana ndi chithandizocho, chimalangizidwa kwa akulu okha.
"Rosuvastatin" ndi mankhwala omaliza. Ndiwothandiza kwambiri kuposa atorvastatin, komanso ali ndi zovuta zochepa.
"Torvakard" ndi chithunzi chonse cha "Atoris". Izi sizikutanthauza kuti ndi mankhwala ati ali bwino. Ndikofunikira kuti zonse ziwiri zimapangidwa ndi makampani otchuka azamankhwala.
"Simvastitatin" ndi mankhwala amibadwo yam'mbuyomu. Monga lamulo, madokotala pafupifupi samapereka mankhwala, chifukwa sichothandiza kwenikweni kuposa Atoris ndipo sichiphatikiza bwino ndi mankhwala ena. Kwenikweni, amatengedwa ndi anthu omwe amathandizidwa kwa nthawi yayitali, komanso othandizira mankhwala mwachilengedwe.

Mayankho abwino

Ndemanga za odwala zimathandizira kuwunikira bwino kwa mankhwala a Atoris. Kuchokera kwa iwo mutha kumva ndemanga zabwino izi:

patatha mwezi umodzi atayamba mankhwalawa, cholesterol yachepetsedwa kwambiri ndikukhazikika.
palibe zotsatira zoyipa zotchulidwa,
mtengo wotsika mtengo poyerekeza ma analogu ena,
mankhwalawa amapangidwa ndi kampani yotchuka, chifukwa chake mutha kutsimikiza kuti kupanga kumayendetsedwa, ndipo mtunduwo umakwanirana ndi European.

Ndemanga zoyipa

Pokhapokha pokhapokha ngati dokotala akupatsirani mankhwala "Atoris". Ndemanga za odwala zithandizanso kumvetsetsa zovuta zomwe zimapezeka povomerezeka ndi chida ichi:

nditamwa mankhwalawa, minofu yanga inayamba kuwawa.
atasiya kumwa mankhwalawo, cholesterol imakwera msanga mokwanira (komanso, chizindikirocho ndi chokwera kuposa kale chithandizo),
pakhungu pakuda,
kutopa kumakulira kwambiri pakumwa mankhwala,
kuyang'anira pafupipafupi ndi dokotala kumafunika.

Pomaliza

Atoris ndi amodzi mwa mankhwala ambiri omwe amachokera pa atorvastatin omwe amapangidwa kuti achepetse cholesterol yamagazi. Komanso, imagwira ntchito pazosungidwa za zinthu zoyipa zomwe zidatha kudziunjikira kale. Mankhwala onse atsopano a gululi amawonekera pamsika, akupikisana mwachangu wina ndi mnzake. Mulimonsemo, adokotala ayenera kusankha mankhwalawo.

Mapiritsi a Atoris, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Malangizo ogwiritsira ntchito Atoris akuwonetsa kuti musanayambe mankhwala ndi kugwiritsa ntchito, samutsani wodwalayo ku chakudyazomwe zipereke lipid kutsika m'magazi. Zakudya ziyenera kutsatiridwa munthawi yonse ya chithandizo. Musanayambe kutenga Atoris, muyenera kuyesa kukwaniritsa zowongolera hypercholesterolemiapakuchita zolimbitsa thupi ndi kuwonda odwala onenepa komanso kudzera mu chithandizo matenda oyamba.

Mapiritsi a Atoris amatengedwa pakamwa (pakamwa), mutatha kudya kapena pamimba yopanda kanthu. Ndikulimbikitsidwa kuyamba mankhwalawa limodzi ndi 10 mg imodzi tsiku lililonse, pambuyo pake, kutengera mphamvu ya mankhwalawo koyambirira ndipo ngati kuli kofunikira kuti muwonjezere, mlingo wapamwamba umaperekedwa - 20 mg, 40 mg, ndi zina mpaka 80 mg. Mankhwala a Atoris, mulingo uliwonse, amatengedwa kamodzi patsiku, nthawi yomweyo patsiku, yabwino kwa wodwalayo. Zotsatira zake zochizira zimawonedwa pambuyo pakugwiritsidwa ntchito kwa milungu iwiri, ndikukula kwa mphamvu yake patatha milungu inayi. Pankhaniyi, kusintha kwa Atoris kwamphamvu kumachitika osati kale kuposa momwe milungu inayi imayendera, poganizira kuchuluka kwa kugwiriridwa kwa mlingo wapitawu. Mlingo wapamwamba kwambiri wa tsiku ndi tsiku wa Atoris ndi 80 mg.

Zochizira Hyperlipidemia yosakanikirana Mtundu wa IIb ndipo choyambirira(polygenicndi cholowa chamabele) hypercholesterolemiaType IIa, amalimbikitsa kumwa Atoris pa 10 mg, ndi kuchuluka kwa mankhwala pambuyo pa milungu inayi, kutengera mphamvu ya mankhwalawa koyambira komanso chidwi cha wodwala aliyense.

Mankhwala cholowa homozygous hypercholesterolemia, kutengera kuwuma kwa mawonekedwe ake, kusankha kwa milingo yoyambirira kumachitika palokha, pamlingo monga mitundu ina Hyperlipidemia.

Odwala ambiri cholowa homozygous hypercholesterolemia mulingo woyenera kwambiri wa Atoris amawonedwa tsiku limodzi mlingo wa 80 mg.

Atoris amatchulidwa ngati njira yowonjezerapo njira zina zamankhwala (mwachitsanzo, plasmapheresis) kapena monga chithandizo chachikulu, ngati kuli kosatheka kuchitira chithandizo ndi njira zina.

Odwala omwe ali ndi matenda a impso ndi ukalamba safuna kusintha kwa mankhwala.

Odwala matenda a chiwindi kuikidwa kwa Atoris ndikotheka kwambiri komanso mosamala kwambiri, chifukwa mu nkhani iyi pamakhala kuchepa pang'ono atorvastatin kunja kwa thupi. Chithandizo cha mankhwalawa chikuchitika motsogozedwa ndi ziwonetsero zasayansi ndi zamankhwala ndipo pakuwonjezereka milingo ya transaminase Kuchepetsa mlingo kapena kumwa mankhwala kwathunthu.

Kuchita

Kugwiritsa ntchito panthawi imodzi atorvastatinndi maantibayotiki (Clarithromycin, Erythromycin, Quinupristine / dalfopristine), NefazodonHIV protease zoletsa (Ritonavir, Indinavir), mankhwala antifungal (Ketoconazole, Itraconazole, Fluconazole) kapena Cyclosporinezingayambitse kuchuluka kwa magazi atorvastatinndi chifukwa myopathiesndi zina rhabdomyolysisndi chitukuko kulephera kwa aimpso.

Kugwiritsa ntchito kwa Atoris ndi nicotinic acid ndi mafupamu lipid kutsitsa Mlingo (oposa 1 g / tsiku), komanso 40 mg atorvastatinndi 240 mg Diltiazemazimapangitsanso kuchuluka kwa magazi atorvastatin.

Kugwiritsa ntchito Atoris ndi Rifampicinndi PhenytoinImachepetsa kugwira ntchito kwake.

Maantacid(kuyimitsidwa aluminium hydroxides ndi magnesium) sinthani zomwe zili atorvastatinm'magazi.

Kuphatikiza Atoris ndi Colestipolamachepetsa ndende atorvastatinm'magazi ndi 25%, koma ali ndi othandizira ochulukirapo, poyerekeza ndi Atoris yekha.

Chifukwa chakuwonjezeka kwa kuchepa kwa maselo am'madzi a steroid am'mbuyomu, kusamala ndikofunikira popereka Atoris ndi mankhwala omwe amachepetsa kuchuluka kwa mahomoni amkati a steroid (kuphatikiza Spironolactone, Ketoconazole, Cimetidine).

Odwala nthawi yomweyo kulandira Atoris pa mlingo wa 80 mg ndi Digoxiniyenera kuyang'aniridwa mosalekeza, chifukwa kuphatikiza uku kumapangitsa kuchuluka kwa magazi Digoxin, pafupifupi 20%.

Atorvastatinzitha kuyamwa kulera kwamlomo (Ethinyl estradiol, Norethindrone) ndipo, motero, kuwayika kwawo plasma, komwe kungafune kukhazikitsidwa kwa njira ina yolera.

Kugwiritsa ntchito kwa Atoris ndi Warfarin, kumayambiriro kwa kugwiritsidwa ntchito, kumatha kuwongolera zotsatira zakumapeto kwake poyanjana ndi magazi a magazi (kuchepa kwa PV). Izi zimachitika pambuyo masiku 15 olowa mankhwala.

Atorvastatinilibe gawo lalikulu pakanthawi ya kinetics Terfenadine ndi Phenazone.

Kugwiritsa ntchito 10 mg Amlodipinendi 80 mg atorvastatinsizimabweretsa kusintha mu pharmacokinetics yotsiriza pakufanana.

Milandu ya mapangidwe akufotokozedwa. rhabdomyolysisodwala omwe nthawi yomweyo amatenga Atoris ndipo fusidic acid.

Ntchito ya Atoris ndi estrogenndi antihypertensive mankhwala, mkati mwa njira yolowa m'malo, sanawonetse chiyanjano chosafunikira.

Madzi a mphesa, mu kuchuluka kwa malita 1.2 patsiku, munthawi ya chithandizo ndi Atoris kungayambitse kuchuluka kwa mankhwala a plasma, chifukwa chake, kumwa kwake kuyenera kukhala kochepa.

Zolemba pa Atoris

Ma Atoris analogs amaimiridwa ndi mankhwala omwe ali pafupi nawo momwe amagwirira ntchito. Ma fanizo ofala kwambiri ndi awa:

Mtengo wa analogues umasiyana siyana ndipo zimatengera wopanga, kuchuluka kwa zophatikizira ndi kuchuluka kwa mapiritsi. Chifukwa chake mapiritsi Simvastatin10 mg No. 28 ingagulidwe kwa ma ruble 250-300, ndipo Crestor10 mg No. 28 kwa ma ruble a 1500-1700.

Mtengo wa Atoris, komwe mugule

M'mafakitala aku Russia, mtengo wa mankhwalawa umasiyanasiyana kwambiri, mwachitsanzo, mtengo wa Atoris 10 mg No. 30 ungasiyane ndi ma ruble 400-600, mtengo wa Atoris 20 mg No. 30 kuchokera pa 450 mpaka 1000 rubles, 40 mg mapiritsi No. 30 kuchokera ku 500 mpaka 1000 rubles.

Mutha kugula mapiritsi ku Ukraine pafupifupi: 10 mg No. 30 - 140 hryvnia, 20 mg No. 30 - 180 hryvnia, 60 mg No. 30 - 300 hryvnia.