Zotupa zam'mimba

Khansa yapakansa - neoplasm yoyipa yochokera ku epithelium ya glandular minofu kapena ma pancreatic ducts.

Khansa yapakansa
ICD-10	C 25 25.
ICD-10-KM	C25.0, C25.1 ndi C25.2
ICD-9	157 157
ICD-9-KM	157.1, 157.8, 157.0 ndi 157.2
Omim	260350
Diseasesdb	9510
Medlineplus	000236
eMedicine	med / 1712
Mesh	D010190

Chiwopsezo cha khansa ya kapamba chikukula chaka chilichonse. Matendawa ndi khansa yachisanu ndi chimodzi yodziwika bwino pakati pa anthu akuluakulu. Zimakhudza makamaka okalamba, nthawi zambiri amuna ndi akazi. Ku United States, khansa ya kapamba pakadali pano ndi malo achinayi pazomwe zimayambitsa kupha khansa. Malinga ndi kafukufuku woyambirira wa bungwe la American Cancer Society, mu 2015, chotupa chija chapezeka mwa anthu 48 960, ndipo odwala 40 560 afa. Chiwopsezo cha khansa mwa aliyense wokhala ku United States pa moyo ndi 1.5%.

Zomwe zimayambitsa khansa ya pancreatic ndi:

Matenda opatsirana ophatikizidwa ndi:

Nthawi zambiri, chotupa chimakhudza mutu wa ndulu (50-60% ya milandu), thupi (10%), mchira (5-8% ya milandu). Palinso kwathunthu kwa kapamba - 20-35% ya milandu. Chotupa ndi malo owuma kwambiri osakhala ndi malire omveka bwino; m'gawolo, ndi loyera kapena chikaso chopepuka.

Mtundu wapezeka posachedwa womwe umakhudza mawonekedwe a maselo apadera a pancreatic, omwe angatenge nawo gawo la khansa. Malinga ndi kafukufuku yemwe adalembedwako mu magazini yotchedwa Nature Communications, mtundu womwe umalinga ndi P1 protein kinase gene (PKD1). Mwa kuchitapo kanthu, zitha kulepheretsa kukula kwa chotupacho. PKD1 - imayang'anira kukula kwa chotupa ndi metastasis. Pakadali pano, ofufuza akutanganidwa kupanga PKD1 inhibitor kuti iyesedwe mopitilira.

Kafukufuku yemwe adachitika ku Langon Medical Center ku University of New York adapeza kuti khansa ya kapamba idali 59% yodziwika bwino mwa odwala omwe ali ndi tizilombo toyambitsa matenda pakamwa. Porphyromonas gingivalis. Komanso, chiopsezo cha matendawa chimakwera kawiri ngati wodwala wapezeka Aggregatibacter actinomycetemcomitans. Chiyeso chowunikira chikupangidwa chomwe chitha kudziwa mwayi wokhala ndi khansa ya kapamba.

Pazonse, pali mitundu isanu ya mbiri ya khansa ya kapamba:

• Adenocarcinoma
• Squcinous cell carcinoma
• Cystadenocarcinoma
• Acinar cell carcinoma
• Khansa yopanda chidwi

Edenocarcinoma wodziwika bwino amapezeka 80% ya khansa ya kapamba.

Lymphogenic metastasis ya khansa ya kapamba imakhala ndi magawo anayi. Mu gawo loyamba, ma pancreatoduodenal lymph node amakhudzidwa (pafupi ndi mutu wa kapamba), lachiwiri - retropiloric ndi hepatoduodenal, kenako celiac komanso apamwamba a mesenteric lymph node, ndipo mu gawo lachinayi - retroperitoneal (paraaortic) lymph node.

Hemato native metastasis imabweretsa chitukuko cha metastases yakutali mu chiwindi, mapapu, impso, mafupa.

Kuphatikiza apo, pali kukhazikika kwa kusintha kwa maselo a chotupa m'mbali mwa peritoneum.

Gulu la Clinical TNM limangogwiritsa ntchito exocrine pancreatic carcinomas ndi zotupa za pancreatic neuroendocrine, kuphatikizapo carcinoids.

T - chotupa chachikulu

• Tx - chotupa choyambirira sichitha kuyesedwa
• T0 - kusowa kwa data pa chotupa choyambirira
• Tis - carcinoma ku situ
• T1 - chotupa osaposa 2 cm kukula kwakukulu mkati mwa kapamba
• T2 - chotupa chachikulu kuposa 2 cm mu kukula kwakukulu mkati mwa kapamba
• T3 - chotupa chija chimapitilira kapamba, koma sichikhudza thunthu la celiac kapena chotupa chachikulu cha mesenteric
• T4 - chotupa chimamera mu celiac thunthu kapena mkulu wa mesenteric artery

Tis imaphatikizanso ndi pancreatic intraepithelial neoplasia III.

N - madera a lymph nodes

• Nx - Malo a m'mimba sangathe kuwunika.
• N0 - palibe metastases m'chigawo cha lymph node
• N1 - pali metastases m'chigawo cha lymph node

Ndemanga: Ma lymph node ndi ma periopancreatic node, omwe amatha kugawidwa motere:

M - metastases yakutali

• M0 - palibe metastases yakutali,
• M1 - pali metastases yakutali.

Zizindikiro za khansa ya pancreatic nthawi zambiri sizikhala zachindunji komanso osafotokozeredwa, pomwe chotupa chimapezeka nthawi zambiri. Mwa zina mwazovuta, jaundice yolepheretsa imapezeka kwambiri pakumera kapena kukakamira kwa ma ducts a bile.

Ngati chotupa chikukhudza mutu wa nduluyo, ndiye imadziwoneka ngati Courvoisier syndrome: palpation ya kumtunda kwamtunda wamatumbo anayi, chikhodzodzo chimakulitsidwa chifukwa cha kukakamizidwa kwa bile. Khansa yamthupi ndi mchira wa kapamba imayendera limodzi ndi kupweteka kwa epigastric, komwe kumawunikira kumbuyo kwakumbuyo ndipo zimatengera malo a thupi. Kumera chifukwa cha chotupa m'mimba ndi m'mimba yopingasa kumayambitsa kusokonezeka mu mawonekedwe awo. Mtsogolomo, ntchito ya gland ndi ziwalo zina zam'mimba zimasokonekera. Kutulutsa magazi kwa ziwalo zomwe zakhudzidwa.

Khansa ya kapamba imayendera limodzi ndi zizindikiro zofala zam'mimba zotupa: kuledzera khansa, kuchepa kwa chakudya ndi thupi, kufooka, kutentha thupi, ndi zina zambiri.

Njira zachikhalidwe zofufuzira zamtundu wazathu ndi ultrasound ndi compact tomography yokhala ndi kuphatikiza kwa bolus. Njirazi zimatipangitsa kuwona m'maso osati kuchuluka kwa chotupa chachikulu, komanso kuwunika kwa metastases, concomitant pathology. Kuphatikiza apo, njira za X-ray zimagwiritsidwa ntchito molingana ndi zomwe zikuwonetsa, monga kupenda m'mimba ndi duodenum ndi barium sulfate (kuwunika kukhalapo kwa kudzaza zolakwika chifukwa cha kukakamira kwa chotupa), endoscopic retrograde cholangiopancreatography (kuwunika kuchuluka kwa zotupa za bile ndi pancreatic ducts, kutsimikizika kwa morphological). Pazifukwa zodziwira, laparotomy yokhala ndi biopsy ikhoza kugwiritsidwa ntchito.

Kuphatikiza pa njira zodziwira mawonekedwe a anatomical kapangidwe ka kapamba, pali njira zomwe zimatha kudziwa payokha matendawa. Njira imodzi ndiyo kutsimikiza kwa matrix metalloproteinases m'mwazi.

Endoscopic Ultrasound Sinthani

Kupita patsogolo kwakukulu pakuwonetsa khansa ya pancreatic kumayambiriro koyambira ndi endosonography (endoscopic ultrasound). Mosiyana ndi mavidiyo wamba, makina osunthika omwe ali ndi kamera ya kanema komanso kafukufuku wapakanema amagwiritsidwa ntchito pa endosonography, yomwe ikhoza kuyikidwa mu matumbo molunjika ku mapangidwe omwe aphunziridwa. Endosonography imathetsa vuto la kufotokozera bwino lomwe kumachitika mukamayang'ana ziwalo zozama ndi njira yopatsirana. Mu khansa ya pancreatic, endoscopic ultrasound imakupatsani mwayi wokhazikitsa matenda mu 90-95% ya milandu fotokozerani koyambirira.

Jack Andraki Woyeserera Sinthani

Kumayambiriro kwa chaka cha 2012, a Jack Andraka, bambo wazaka 15 kuchokera ku North County High School ku Baltimore mdera la Glen Burnie, Maryland, USA, adapeza njira yofufuzira khansa yomwe ingadziwitse khansa yamapapo, mapapo, komanso khansa ya testicular. magawo oyambirira posanthula magazi kapena mkodzo. Woyesererapo yemwe adatchulidwa adapangidwa pamiyeso ya pepala yoyeserera matenda ashuga.

Malinga ndi wolemba, potengera zolakwika zolakwika, njirayi imakhala yotentha kwambiri mopitilira zana, kutsika kwambirimbiri mtengo (wolemba pepala wopanga zinthu zochuluka sawotcha masenti atatu), ndipo ndiwodziwikirapo kwambiri kuposa njira zomwe zidalipo kale kuyesa. Kulondola kwa mawu oyambirirawa atha kukhala 90% kapena kuposa. Kukula ndi kufufuza kwa yemwe anayambitsa wachinyamata kunayambitsidwa ndi imfa ya khansa ya pancreatic ya bwenzi lapamtima la mnyamatayo.

Pakukula kwake, Jack Andraca adalandira chiphaso cha $ 75,000 mu Meyi 2012 pa Worldwide Student and Science Achievement Competition, womwe umachitika chaka chilichonse ku USA (Intel ISEF 2012). Thandizo lidathandizidwa ndi Intel. Mu Januware 2014, nkhani idasindikizidwa m'magazini ya Forbes yomwe idatsutsa momwe Jack Andrak adayesedwera.

• Kuthandizira opaleshoni (malinga ndi zikuwonetsa, posapezeka ma metastases - mu milandu ya 10-15%)
• Radiotherapy (mogwirizana ndi opaleshoni)
• Chemotherapy
• Hormone mankhwala
• Syndrome dalili (anesthesia, etc.)
• Virotherapy
• Osintha Zinthu (Nanorear)

Mwa njira zopangira opaleshoni, pancreatoduodenal resection ndizodziwika kwambiri mu khansa ya pancreatic (Ntchito ya Whipple), yomwe imaphatikizapo kuchotsa mutu wa kapamba ndi chotupa, gawo la duodenum, gawo lam'mimba ndi chikhodzodzo cha ndulu ndi zigawo za m'mimba. Kuphwanya kwa opaleshoni ndikufalitsa chotupa m'matumba akuluakulu oyandikana ndi kupezeka kwa metastases yakutali.

Chithandizo cha postoperative, chotchedwa adjuvant therapy, chimaperekedwa kwa odwala omwe alibe chizindikiro chotsala cha matenda otsalira, koma pali mwayi kuti tinthu tating'onoting'ono tomwe timakhala m'thupi timakhala m'thupi, womwe, ngati utapanda kuchitidwa, ungayambitse chotupa komanso kufa.

Zikhalidwe sizabwino. Njira zamakono za opaleshoni zimatha kuchepetsa kufa kwa perioperative mpaka 5%. Komabe, kupulumuka kwapakatikati pambuyo pakuchita opaleshoni ndi miyezi 15-19, ndipo kupulumuka kwa zaka zisanu kumakhala kochepera 20%. Ngati kuchotsa kwathunthu kwa chotupacho sikungatheke, kuyambiranso kumachitika nthawi zonse, mwa odwala omwe ayambiranso kutalikirana ndi moyo wamtali wamtundu wa 3-4 kuposa momwe amachitidwira odwala osagwiritsa ntchito. Mkhalidwe wamakono wamankhwala samalola kulandira chithandizo chokwanira cha khansa ya pancreatic ndipo imangoyang'ana kwambiri za chithandizo chamankhwala. Nthawi zina, zotsatira zopindulitsa zimaperekedwa ndi interferon mankhwala. Mwamba wokupulumuka wazaka 5 atachitidwa opaleshoni yayikulu ndi 8-45%, zomwe zimapangitsa kukhala imodzi mwamatenda oopsa.

Zambiri

Zotupa za pancreatic zimatha kupanga endocrine komanso mbali yake, koma exocrine neoplasms predomine. Pakati pawo, zotupa zoyipa zimapezeka, mu 90% ya milandu yoyimitsidwa ndi pancreatic duct adenocarcinoma. Zotupa za Benign ndizosowa, zimapangika makamaka kuchokera ku maselo omwe amapanga michere yamagayidwe am'mimba, komanso malire a ducts (cystadenoma). Ma tumors omwe amapangidwa kuchokera ku maselo a Langerhans (gawo la endocrine la kapamba) amatha kugwira ntchito molimbitsa thupi. Zotupa zotheka ku Hormon zimakhala ndi chipatala chowala kwambiri, chifukwa zimatulutsa zinthu zambiri zomwe zimagwira komanso zimayambitsa "chimphepo cha mahomoni" m'thupi. Kafukufuku wokhudzana ndi pancreatic oncopathology amatsimikizira kuti zotupa za chiwalochi mwa akazi zimapezeka kawiri kawiri kuposa amuna, ndipo chiwopsezocho chimachitika zaka 35-50.

Pancreatic chotupa chamtundu

Ma neoplasms onse kuchokera ku zomwe adachokera amagawidwa kukhala osiyanitsa (osiyanitsidwa kwambiri) ndi oyipa (osayenerana). Kuphatikiza apo, zotupa za pancreatic zimagawidwa potengera kutengera kwina, mapangidwe a mbiriyakale, zovuta zamagulu. Pancreatic neoplasm ikhoza kukhala pamutu, thupi, mchira, zilumba za Langerhans, ducts, kapena komwe tumor node sakutchulidwa.

Malinga ndi dongosolo la histological, mu 80% ya milandu, zotupa za pancreatic ndizoyambira epithelial (kuchokera ma cell a acinar ndi endocrine, ductal epithelium, osadziwika kapena magwero osakanikirana), minyewa yopanda epithelial, magazi ndi mitsempha ya minyewa imatha kukhala gwero, ndipo ma neoplasms amathanso kukhala ndi magwero a dysontogenetic komanso metastatic.

Mitundu yotsatirayi ya zotupa za kapamba za epithelial zimasiyanitsidwa: kuchokera ku ma cell a acinar (benign - adenomas, malignant - acinar-cell cancer), duct epithelium (benign - cystadenomas, malignant - adenocarcinoma, Scirr, squamous and anaplastic cancer.

Zotupa za pancreatic endocrine zimachokera ku masheponi a Langerhans (insulinomas, gastrinomas, vipomas) kapena beuse (carcinoid). Malinga ndi kuchuluka kwa kusiyanasiyana kwa maselo, amatha kukhala osiyana kwambiri, apakatikati, komanso osiyanitsa; ma endocrine zotupa zosakanikirana komanso zosadziwika bwino, mucocarcinoids, mitundu yosagwirizana ndi khansa, ma cell a tumor (hyperplasia and ectopy of pancreatic endocrine cell, polyendocrine neoplasia syndrome) amapezekanso.

Kugawika kwamachitidwe kwa zotupa za pancreatic kumaphatikizapo zinthu zotsatirazi: kusowa kwa zisokonezo, kusadziwika kwa magwiridwe antchito, kusowa kwa kapamba: hypofunction, hyperfunction (hypoglycemia ndi hyperglycemia, achlorhydria, kutsegula m'mimba, matenda a Zollinger-Ellison ndi gastrinoma, Werner-Morrison syndrome wokhala ndi polyandocardia neoplasia, hypersecretion wa serotonin).

Ambiri omwe samakhala otupa, ma cymphoid komanso zotupa za kapamba, cystadenocarcinomas, khansa ya squamous ndi acinar amafotokozedwa - milandu yokhayo ya neoplasms iyi imafotokozedwa. Zotupa zodziwika bwino nthawi zambiri zimapangidwa kuchokera ku minofu yathanzi, amapanga osapitirira 0,3% a ma pancreatic neoplasms, mwa atatu mwa anayiwo amaimiridwa ndi insulinoma. Matenda oopsa a neoplasms omwe ali ndi vuto lokhazikika amatha kutsimikiziridwa ndi kupezeka kwa hemato native metastases (nthawi zambiri hepatic). Zovuta zakudziwikiratu kwa ducts zimapanga 90% ya zotupa za kapamba ndi 80% ya zigawo za pancreatobiliary.

Zizindikiro za zotupa za kapamba

Zotupa zambiri za kapamba zimatha kudziwonetsa kwazaka zambiri. Ngati chipatala cha neoplasm chawoneka, mfundo zotsatirazi zikuyimira kumbuyo kwa chosaopsa chotupa: kusapezeka kwa mbiri ya khansa ya kapamba pamzere, kusapezeka kwa chipatala chotchulidwa cha matenda ndi zizindikiro za kuledzera.

Ma Adenomas akuchokera kwa pancreatic alibe mawonetsedwe azachipatala; amapezeka mwangozi pakagwiritsidwe ntchito opaleshoni kapena mthupi.Ma cystadenomas ndi cystadenocarcinomas amatha kukula kwambiri ndipo chifukwa cha izi amawonetsedwa komanso kutuluka khoma kudzera mkati mwa khoma lam'mimba lakunja. Nthawi yomweyo, chithunzi cham'chipatala sichikupezeka kwa nthawi yayitali ndipo chikuwonekera kumapeto kwa chotupa pomwe chotupa chikuyamba kufinya bile duct komanso pancreatic duct, matumbo, ziwiya zapafupi ndi mitsempha.

Chipatala chochititsa chidwi kwambiri ndi zotupa zomwe zimagwira m'magazi: kuchuluka kwa insulin nthawi yayitali kumabweretsa hypoglycemia, gastrinoma imafotokozedwa pakupanga Zollinger-Ellison syndrome (zilonda zam'mimba, hypersecretion yayikulu ya madzi a m'mimba, njira zoyipa za matendawa), njoka zimawonetsedwa ndi Werner-Morrison syndrome (kutsegula m'mimba) , achlorhydria), carcinoid - hyperserotoninemia ndi carcinoid syndrome (kutentha kwa mtundu wa kukokana, kutsegula m'mimba, kukokana kwam'mimba, kusakwanira Izi Machine mtima kumanja).

Chipatala cha zotupa zoyipa za ma pancreatic ducts nthawi zambiri chimangowoneka kumapeto kwa matendawa, chili ndi mawonekedwe komanso zizindikiro zowonongeka kwa ziwalo zoyandikana. Zizindikiro zodziwika bwino zimagwirizanitsidwa ndi kuledzera kwa chotupa: kupweteka kwam'mimba kutuluka kumbuyo, kuchepa thupi, kuchepa kwa magazi, kuchepa kwa magazi, kusowa kudya. Kumera kwa chotupa mu ziwalo zozungulira komanso ziwonetsero kumadziwonetsera ndi zizindikiro zowonongeka kwa ziwalo izi (ascites ndi kupindika kwamitsempha, jaundice ndi exocrine pancreatic insufficiency ndi kutsekeka kwa wamba duct ndi wamba bile duct, zizindikiro za kuwonongeka m'mimba, ndi zina zambiri.

Kuzindikira zotupa za kapamba

Kuti mupeze nthawi yake komanso kutsimikiza kolondola kwa mtundu wa chotupa cham'mimba, ntchito yolumikizidwa ya gastroenterologist, dokotala wa opaleshoni ndi endoscopist imafunika. Popanda kugwiritsa ntchito njira zamakono zowonera ndi kuyimira kwa ma neoplasms, ndizosatheka kuzindikira chotupa. Tiyenera kukumbukira kuti ngakhale zida zamakono komanso njira zamakono zowonera sizimatha kuyankha funso lililonse pamtundu wa zotupa, komanso chidziwitso chazachipatala chomwe adokotala amapita ndizofunikira kwambiri pakuwazindikira ma neanclasms apancreatic.

Zilonda za pancreatic zidzawonetsedwa ndi maphunziro monga kuyezetsa magazi a biochemical, pulogalamu yamapulogalamu, kafukufuku wamasungidwe amadzimadzi amadzimadzi ndi esophagogastroduodenoscopy. Gawo lotsatira ndikukhazikitsa njira zosavulaza monga gastrography ndi duodenography, maginito a resonance pancreatocholangiography, kulingalira kwa maginito oyambanso kupanikizika, kuphatikizidwa kwa tomography ya thirakiti la biliary. Atazindikira chotupa mu pancreatic tishu (kukula kwa neoplasm amatha kusiyanasiyana kuchokera pa 2 mm mpaka 200 mm), kuchuluka kwa ma homons ndi metabolites (adrenaline, norepinephrine, serotonin, cortisol, gastrin, pasoide ya vasoactive, insulin, glucagon, pancreatic ndi C-peptide yotsimikiza mu magazi. , somatostatin, etc.) ndi zotupa zolembera (CA19-9, CA 50, CA 242, CEA).

Kuti mumvetse bwino momwe zilondazo zimakhalira, njira zowononga zachilengedwe zimagwiritsidwanso ntchito: endoscopic retrograde cholangiopancreatography, celiacography potenga magazi kuchokera ku mitsempha ya pancreatic ndikudziwona mahomoni mkati mwake, percutaneous transhepatic cholangiography, pancreatic puncture biopsy, laparoscopy. Kafukufuku wambiri omwe amafunikira kuti azindikire chotupa cha pancreatic akuwonetsa kuti kudziwika kwa matendawa ndi kovuta kwambiri, ndipo njira yoyesera yodziwira sanapezekebe.

Pancreatic zotupa ziyenera kusiyanitsidwa ndi chifuwa chachikulu cha kapamba, chifuwa cham'mimba, zotupa zowonjezera zam'mimba komanso zotupa za mesentery zamatumbo, kulowetsedwa kwa zilonda zam'mimba kapena duodenum, chotengera chachikulu cha chotupa, echinococcosis ndi cysticercosis ndi kuwonongeka kwa hepatopanreatic zone.

Chithandizo cha chotupa cha pancreatic

Chithandizo cha chosaopsa chotupa amangochita opaleshoni: distal kapamba resection, kapamba mutu pancreatic, resection ya pancreatoduodenal, chotupa. Pambuyo pa opaleshoni, kuyesedwa kwofunikira kwa mbiriyakale kumachitika pofuna kufotokoza mtundu wa neoplasm.

Mu neoplasms yoyipa, njira zazikulu zamankhwala zimasankhidwa potengera momwe matenda amathandizira. Ngati wodwala wadwala khansa yodwalitsa kapena khansa yokhazikika yomwe imagwira ntchito kumutu kwa kapamba, chifuwa chamimbayo chimachitika ndikusunga m'mimba pyloric. Mu gastrinomas, gastrectomy, kusankha vagotomy, ndi pancreatoduodenal reseation nthawi zambiri zimachitidwa, komabe, kutsogolera gastroenterologists ndi madokotala ochita opaleshoni amatsutsanabe za kuthandizira ndi kuthekera kwa mauthengawa.

Chithandizo chovuta cha zotupa za pancreatic chikuphatikizira poizoniyu ndi polychemotherapy (yokhala ndi kuchuluka kwakukulu, mphamvu yogwira yamahomoni, matenda oopsa ndi metastasis ya neoplasm). Palliative mankhwala a zilonda zam'mimba neoplasms umalimbana kubwezeretsa kutuluka kwa ndulu ndi zikondamoyo, kuthetsa yotupa mu ndulu ducts, ndi kukonza wodwalayo moyo. Pazifukwa zopangika, ntchito zotsatirazi zimachitika: ngalande zakunja za ndulu zamkati molingana ndi Kerr ndi Halsted, percutaneous transhepatic drainage of the bile ducts, cholecystectomy, endoscopic mayeso a chotupa solidurepic bile ducts, endoscopic stenting of the bile duct, etc.

Mankhwala osokoneza bongo a benign neuroendocrine zotupa zamagetsi ochepera, mawonekedwe osaneneka a endocrine akuphatikizira ndi sandostatin ndi omeprazole. Pochiza chotupa monga gastrinoma, chophatikiza cha H2 blockers cha histamine receptors, anticholinergics ndi proton pump inhibitors amagwiritsidwa ntchito mwakhama.

Kuneneratu ndikupewa zotupa za pancreatic

Kudziwika kwa zotupa zoyipa za kapamba kumakhala kosavomerezeka, komwe kumalumikizidwa ndi maphunziro awo asymptomatic komanso kuzindikira mochedwa. Kuchotsa chotupacho mosachedwa kumatheka pokhapokha wodwala aliyense khumi, chotupa chilichonse chimayambiranso, ndipo mu 95% ya miyezi 12 yoyambirira atachitidwa opaleshoni, metastases yakutali yapezeka. Chithandizo chophatikizidwa sichikulitsa kwambiri miyezo yopulumuka: osapitirira 5% ya odwala omwe ali ndi zotupa zoyipa za pancreatic amakhalabe amoyo zaka zisanu.

Matenda a benign pancreatic chotupa ndi abwino - mwa odwala asanu ndi anayi mwa khumi amatha kukwaniritsa machiritso athunthu. Kuphatikiza apo, zophatikizira zamomwe izi zimachitika ndizosowa kwenikweni. Palibe chindapusa chilichonse cha zotupa za pancreatic, komabe, kutsatira moyo wathanzi, kudya mokwanira, komanso kupuma mokwanira kumachepetsa kupangika kwa neoplasms iliyonse mthupi.