Mapiritsi - 1 piritsi:

Zogwira pophika: metformin hydrochloride 500 mg / 850 mg / 1000 mg,
Othandizira: hypromellose 2208 5.0 mg / 8.5 mg / 10,0 mg, povidone K90 (collidone 90F) 20,0 mg / 34.0 mg / 40.0 mg, sodium stearyl fumarate 5.0 mg / 8, 5 mg / 10,0 mg
Kanema wamadzi wosungunuka wamadzi: hypromellose 2910 7.0 mg / 11.9 mg / 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 0,9 mg / 1.53 mg / 1.8 mg, polysorbate 80 (pakati 80) 0, 1 mg / 0.17 mg / 0,2 mg, titanium dioxide 2.0 mg / 3.4 mg / 4.0 mg.

Mapiritsi okhala ndi mafilimu 500 mg, 850 mg, 1000 mg.

Katundu woyamba wa mankhwala

Pa mapiritsi 10 mumtambo wokutira kuchokera ku filimu ya polyvinyl chloride ndi zojambulazo zotayidwa za aluminium.

Mapiritsi a 15, 30, 60, 100, 120 ali mumtsuko wama polima wopangidwa ndi polyethylene wokhala ndi chivindikiro chotsekedwa ndi ulamuliro wotseguka koyamba. Malo aulere amadzazidwa ndi thonje lachipatala. Zolemba zopangidwa ndi pepala lolemba kapena zolemba, kapena zomatira zomata zolimba, amazikongoletsa m'mabanki.

Ma CD a sekondale

1, 2, 3, 4, 5, 6, 8, 9, kapena 10 matuza, pamodzi ndi malangizo ogwiritsira ntchito, amaikidwa pakatoni kakhadi kuti ogula azigwiritsa ntchito.

1 imodzi pamodzi ndi malangizo ogwiritsira ntchito amaikidwa pakatoni kadulidwe ka ogula.

Mapiritsi a 1000 mg: mapiritsi a oblong biconvex ophatikizidwa ndi filimu yoyera yokhala ndi ngozi mbali imodzi. Pamtanda, pakati ndi yoyera kapena pafupifupi yoyera.

Wothandizira hypoglycemic wa gulu la Biguanide kuti agwiritse ntchito pakamwa.

Madzi ndi kugawa

Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera kumimba kwathunthu. Mtheradi bioavailability ndi 50-60%. Kuchuluka kwa ndende (Cmax) (pafupifupi 2 μg / ml kapena 15 μmol) m'madzi a plasma kumachitika pambuyo pa maola 2.5. Ndi kukakamiza komweko pakudya, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa.

Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma.

Kutetemera ndi chimbudzi

Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuwonekera kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa kutulutsa chilolezo cha creatinine), zomwe zikuwonetsa kukhalapo kwa kubisala kwa canalic secretion. Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kukopeka kwa mankhwalawa.

Metformin imachepetsa hyperglycemia popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis. Kuchepetsa mayamwidwe m'matumbo. Metformin imathandizira kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose. Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yonse, lipoproteins yotsika komanso triglycerides.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono. Kafukufuku wachipatala adawonekeranso kugwira ntchito kwa metformin popewa matenda ashuga odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa mtundu wachiwiri wa matenda ashuga, momwe kusintha kwasinthidwe kwa moyo sikunalole kuti chiwonetsero chokwanira cha glycemic chikwaniritsidwe.

Zizindikiro zogwiritsidwa ntchito Merifatin

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, omwe samachita bwino pakudya ndi masewera olimbitsa thupi:

Akuluakulu, monga monotherapy kapena kuphatikiza ena amkamwa hypoglycemic othandizira kapena insulin,
mwa ana kuyambira azaka 10 monga monotherapy kapena osakaniza insulin. Kupewera kwa matenda ashuga amtundu wa 2 odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa matenda a shuga a 2, momwe kusintha kwasinthidwe sikunalole kuti chiwopsezo cha glycemic chikwaniritsidwe.

Contraindication Merifatin

Hypersensitivity to metformin kapena kwa aliyense wakonda,
matenda ashuga ketoacidosis, matenda a shuga, chikomokere,
Kulephera kwaimpso kapena kuwonongeka kwaimpso (kulengedwa kwa creatinine kupitirira 45 ml / min),
zovuta pachimake ndi chiopsezo cha aimpso kukanika: kuchepa magazi (ndi m'mimba, kusanza), matenda opatsirana, mantha,
mwaukadaulo wawonetsera matenda owopsa kapena osachiritsika omwe angayambitse kukula kwa minofu hypoxia (kuphatikizapo kupweteka kwa mtima, kuperewera kwa mtima ndi hemodynamics yosakhazikika, kupuma, kuperewera kwamatenda am'mimba.
opaleshoni yayikulu ndi zoopsa pamene akuwonetsa chithandizo cha insulin,
Kulephera kwa chiwindi, kuwonongeka kwa chiwindi,
uchidakwa wambiri, chakumwa chakumwa choledzeretsa,
mimba
lactic acidosis (kuphatikizapo mbiri),
ntchito kwa maola osakwana 48 isanachitike komanso mkati mwa maola 48 mutachita maphunziro a radioisotope kapena x-ray ndikukhazikitsa ma iodine okhala ndi zosiyana pakati,
kutsatira zakudya zama hypocaloric (zosakwana 1000 kcal / tsiku).

Gwiritsani ntchito mosamala mankhwalawa:

mwa anthu azaka zopitilira 60 omwe amagwira ntchito zolimbitsa thupi, zomwe zimagwirizanitsidwa ndi chiopsezo chowonjezereka cha lactic acidosis,
Odwala aimpso kulephera (creatinine chilolezo 45-59 ml / min),
Pa yoyamwitsa.

Gwiritsani ntchito Merifatin m'mimba komanso ana

Matenda a shuga omwe sanakulipiridwe panthawi ya kubereka amalumikizidwa ndi chiwopsezo chowonjezeka cha zilema zakubadwa ndi kufa kwa perinatal. Zambiri zomwe zikusonyeza kuti kutenga metformin mwa amayi apakati sikuti kumawonjezera mwayi wokhala ndi vuto la kubala mwa ana.

Pokonzekera kutenga pakati, komanso ngati mayi ali ndi pakati pam'mbuyo pa kutenga matenda a metformin omwe ali ndi prediabetes ndi mtundu wachiwiri wa shuga, mankhwalawo ayenera kusiyidwa, ngati vuto la matenda ashuga a mtundu wa 2, limaperekedwa. Ndikofunikira kusungitsa glucose omwe ali m'madzi am'magazi pamlingo woyandikira kwambiri kuti achepetse vuto la fetus.

Metformin imadutsa mkaka wa m'mawere. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke. Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa sikulimbikitsidwa. Lingaliro loletsa kuyamwitsa liyenera kuganiziridwanso zabwino za kuyamwitsa ndi chiopsezo cha zotsatira zoyipa mwa khanda.

Kutulutsa mawonekedwe, ma CD ndi kapangidwe kake

Mapiritsi, atakulungidwa ndi utoto wa filimu yoyera, ndi oblong, biconvex, wokhala pachiwopsezo mbali imodzi, pamtanda wa gawo loyera kapena loyera.

1 tabu
metformin hydrochloride	1000 mg

Othandizira: hypromellose 2208 - 10 mg, povidone K90 (collidone 90F) - 40 mg, sodium stearyl fumarate - 10 mg.

Kanema wamadzi wosungunuka wamadzi: hypromellose 2910 - 14 mg, polyethylene glycol 6000 (macrogol 6000) - 1,8 mg, polysorbate 80 (pakati 80) - 0,2 mg, titanium dioxide - 4 mg.

Ma PC 10 - matumba otumphuka (1) - mapaketi a makatoni.
Ma PC 10 - mapepala otumphukira (2) - mapaketi a makatoni.
Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 10 - mapaketi a matuza (4) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (5) - mapaketi a makatoni.
Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (7) - mapaketi a makatoni.
Ma PC 10 - matumba otumphukira (8) - mapaketi a makatoni.
Ma PC 10 - mapepala otumphukira (9) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (10) - mapaketi a makatoni.
15 ma PC. - zitini (1) - mapaketi a makatoni.
30 ma PC - zitini (1) - mapaketi a makatoni.
Ma PC 60. - zitini (1) - mapaketi a makatoni.
Ma PC 100 - zitini (1) - mapaketi a makatoni.
Ma PC 120 - zitini (1) - mapaketi a makatoni.

Zotsatira za pharmacological

Oral hypoglycemic wothandizila kuchokera pagulu la Biguanides (dimethylbiguanide). Kupanga kwa zochita za metformin kumalumikizidwa ndi kuthekera kwake kuponderezera gluconeogeneis, komanso mapangidwe a mafuta achilengedwe omasuka ndi kukhatikiza kwa mafutawa. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Metformin siyimakhudzanso kuchuluka kwa insulin m'magazi, koma imasintha ma pharmacodynamics pochepetsa kuchuluka kwa insulini kuti imasulidwe ndikuwonjezera kuchuluka kwa insulin kuti proinsulin.

Metformin imalimbikitsa kapangidwe ka glycogen pochita glycogen synthetase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose. Kuchepetsa mayamwidwe m'matumbo.

Amachepetsa msana wa triglycerides, LDL, VLDL. Metformin imakweza michere yamagazi ya fibrinolytic mwa kuponderezana ndi minyewa yokhala ngati minofu ya plasminogen activator inhibitor.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imayamba pang'onopang'ono komanso osakwanira kuchokera mmimba. C max mu plasma imafikiridwa patatha pafupifupi maola 2,5. Ndi mlingo umodzi wa 500 mg, kupezeka kwathunthu kwa bioavailability ndi 50-60%. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa.

Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma. Amadziunjikira mu ndulu zakumaso, chiwindi ndi impso.

Imafufutidwa ndi impso zosasinthika. T 1/2 kuchokera ku plasma ndi maola 2-6.

Pankhani ya kuwonongeka kwaimpso, kuwerengetsa kwa metformin ndikotheka.

Zizindikiro zamankhwala

Type 2 matenda a shuga a mellitus (osadalira insulini) omwe ali ndi vuto lodyera komanso osachita bwino zolimbitsa thupi, odwala omwe ali ndi kunenepa kwambiri: akuluakulu - monga monotherapy kapena osakanikirana ndi ena othandizira pakamwa kapena ndi insulin, mwa ana azaka zapakati pa 10 ndi akulu - monga monotherapy kapena kuphatikiza ndi insulin.

Nambala za ICD-10

Khodi ya ICD-10	Chizindikiro
E11	Type 2 shuga

Mlingo

Amamwa pakamwa, panthawi ya chakudya kapena itatha.

Mlingo komanso kuchuluka kwa makonzedwe zimatengera mtundu womwe umagwiritsidwa ntchito.

Ndi monotherapy, muyeso umodzi woyamba wa akulu ndi 500 mg, kutengera mtundu womwe umagwiritsidwa ntchito, pafupipafupi makonzedwe ake ndi katatu kapena tsiku. Ndizotheka kugwiritsa ntchito 850 mg 1-2 nthawi / tsiku. Ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono ndi sabata limodzi. mpaka 2-3 g / tsiku.

Ndi monotherapy ya ana azaka zapakati pa 10 ndi akulu, mlingo woyambayo ndi 500 mg kapena 850 1 nthawi / tsiku kapena 500 mg 2 nthawi / tsiku. Ngati ndi kotheka, ndi nthawi osachepera 1 sabata, muyezo mutha kuchuluka mpaka 2 g / tsiku mu Mlingo wa 2-3.

Pambuyo masiku 10-15, mlingo uyenera kusinthidwa kutengera zotsatira za kutsimikiza kwa shuga m'magazi.

Kuphatikiza mankhwala ndi insulin, mlingo woyambirira wa metformin ndi 500-850 mg katatu / tsiku. Mlingo wa insulin umasankhidwa malinga ndi zotsatira za kutsimikiza kwa shuga m'magazi.

Zotsatira zoyipa

Kuchokera pamimba yogaya: kutheka (nthawi zambiri kumayambiriro kwa mankhwalawa) nseru, kusanza, kutsegula m'mimba, kuphwanya pansi, kumva kusasangalala pamimba, munthawi zina - kuphwanya kwa chiwindi, chiwindi (kutha pambuyo poti chithandizo chatha).

Kuchokera kumbali ya kagayidwe: kawirikawiri - lactic acidosis (kuleka kwa chithandizo ndikofunikira).

Kuchokera hemopoietic dongosolo: kawirikawiri - kuphwanya mayamwidwe a vitamini B 12.

Mbiri yamachitidwe osavomerezeka mu ana azaka zapakati pa 10 ndi akulu ndi chimodzimodzi pa akulu.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Amapangidwa monga mapiritsi okhala ndi filimu mu Mlingo wa metformin: 500 mg, 850 mg, 1000 mg.

Zophatikizidwanso:

hypromellose 2208,
sodium walaryl fumarate,
povidone K90,
pachikuto: hypromellose 2910,
titanium dioxide
polysorbate 80
polyethylene glycol 6000.

Amadzaza m'matumba a zidutswa 10, pamatafulidwe okhala ndi matuza kuyambira 1 mpaka 10, kapena m'magalasi okhala ndi magome 15, 30, 60, 100 kapena 120.

Malangizo ogwiritsira ntchito (njira ndi Mlingo)

Merifatin amatengedwa pakamwa kapena mutadya. Mlingo umasankhidwa payekha kutengera umboni ndi zofunikira zenizeni za thupi.

Chithandizo chimayamba ndi kuchuluka kwa 500 mg katatu patsiku. Ngati ndi kotheka, imatha kuwonjezeka pang'onopang'ono - kamodzi pakadutsa masabata 1-2, kuti mupewe zoyipa kuchokera m'mimba. Mulingo waukulu ndi 2-3 g patsiku.

Kwa ana, mlingo woyambirira ndi 500 mg 1-2 kawiri pa tsiku. Pazipita mlingo 2 ga patsiku angapo Mlingo.

Pakupanga mankhwala a insulin, Mlingo wa metformin uyenera kukhala 500-850 mg katatu patsiku, ndipo kuchuluka kwa timadzi timene timasankhidwa kutengera kusanthula kwathu.

Zotsatira zoyipa za mankhwalawa:

lactic acidosis,
thupi lawo siligwirizana
kusanza, kusanza,
zovuta m'mimba
kulawa kwazitsulo mkamwa
mavitamini a vitamini B12,
kuchepa magazi
Ndi kuphatikiza mankhwala - hypoglycemia.

Bongo

Mwina kukula kwa lactic acidosis chifukwa cha kudzikundikira kwa metformin m'thupi. Zizindikiro zake ndi mseru, kusanza, kutsegula m'mimba, kupweteka m'mimba ndi minyewa, kupuma, kutentha pang'ono, thupi limatha kuzindikira. Ngati zizindikiro zotere zikuwoneka, muyenera kusiya kumwa mankhwalawo, gonekerani kuchipatala ndi kuchititsa hemodialysis ndi chithandizo chamankhwala. Ichi ndi chiopsezo cha moyo, makamaka kwa okalamba ndi ana, chifukwa chake ndikofunikira kudziwa zizindikiro zake.

Pogwiritsa ntchito limodzi ndi mankhwala ena kuti muchepetse shuga, magazi a hypoglycemia angachitike. Zizindikiro zake: kufooka, kukomoka, kusanza, kusanza, kusokonezeka (asanagwere chikomokere), njala, ndi zina zambiri. Ndi mawonekedwe ofatsa, munthu amatha kukhazikika pakulima kwake pakudya zakudya zopatsa mphamvu zamankhwala. Mwanthawi yochepa komanso yolimba, jakisoni wa glucagon kapena dextrose solution amafunikira. Kenako munthuyo amafunika kuti azindikiridwe kenako ndi kum'patsa chakudya chamafuta ambiri. Ndikofunikira kuti pambuyo pake mupite kukaonana ndi katswiri kuti akonzere njira ya mankhwalawo.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya mankhwalawa ndi merifatin imalimbikitsidwa ndi:

othandizira ena othandizira
beta blockers,
NSAIDs
danazol
chlorpromazine
clofibrate ofanana nawo
oxytetracycline
Mao ndi ACE zoletsa,
cyclophosphamide,
Mowa.

Mphamvu ya metformin imafooka ndi:

glucagon,
epinephrine
thiazide ndi loop okodzetsa,
glucocorticosteroids,
mahomoni a chithokomiro,
amphanomachul
kulera kwamlomo
phenothiazine zotumphukira,
nicotinic acid.

Cimetidine amachedwetsa kuchotsedwa kwa metformin m'thupi ndipo amatha kuyambitsa lactic acidosis.

Merifatin imatanthauzira momwe ma coumarin amachokera.

Popereka mankhwala ndi wothandizirawa, dokotala wophunzirayo ayenera kudziwa kuchuluka kwa zinthu zomwe zili pamwambapa.

Malangizo apadera

Panthawi yamankhwala, ndikofunikira kuwunika momwe impso zimayendera. Pakukayikira chilichonse chophwanya ntchito yawo, kulandiridwa kwa chida ichi kwathetsedwa.

Metformin palokha siyimakhudza kuyendetsa galimoto, komabe, kuphatikiza ndi insulin kapena sulfonylurea, pamakhala zoterezi. Chifukwa chake, ndi kuphatikiza mankhwala, muyenera kukana kuyendetsa galimoto ndikugwira ntchito ndi zovuta kupanga.

Mowa ungayambitsenso lactic acidosis, chifukwa chake ndi osayenera.

Pochita opaleshoni yomwe ikubwera, panthawi yochizira matenda, kuvulala kwambiri, kufalikira kwa matenda osachiritsika, mankhwalawa sagwiritsidwa ntchito.

Wodwala ayenera kudziwa zizindikiro za zoyipa, hypoglycemia ndi lactic acidosis komanso athe kupereka thandizo.

Mapiritsiwo alibe mafuta am'mimba.

Zofunika! Mankhwala amaperekedwa pokhapokha ngati mwalandira mankhwala!

Kulandila mu ukalamba

Mapiritsi okhala ndi Metformin amagwiritsidwa ntchito pochiza okalamba, koma mosamala, popeza ali ndi chiopsezo chokhala ndi hypoglycemia ndi lactic acidosis, makamaka akamagwira ntchito zolimbitsa thupi. Gulu la zaka lino limafunika kuyang'aniridwa ndi katswiri ndikuwonetsetsa momwe impso zimayang'anira.

Migwirizano ndi magwiritsidwe akusungidwa

Mankhwalawa amayenera kusungidwa m'malo owuma, osawoneka bwino kwa ana kutentha kwa firiji. Nthawi yogwiritsira ntchito ndi zaka 2 kuyambira tsiku lomwe adatulutsa. Kenako mapiritsiwo amatayidwa.

Chida ichi chili ndi ma fanizo angapo. Ndikofunika kuzizolowera kuti mufananitse katundu ndi ntchito yawo.

Bagomet. Mankhwalawa ndi ophatikizika, amaphatikiza mankhwala omwe amagwiritsidwa ntchito ngati metformin ndi glibenclamide. Yopangidwa ndi Chemist Montpelfer, Argentina. Amawononga ndalama zokwana ma ruble 160 phukusi lililonse. Mphamvu ya mankhwalawa imapitilira. The bagomet ndiyosavuta kugwiritsa ntchito ndipo imapezeka m'malo ogulitsa mankhwala. Ili ndi contraindication wamba.

Glformin. Mankhwalawa, omwe amaphatikizapo metformin, amapangidwa ndi kampani yakunyumba Akrikhin. Mtengo wa ma CD umachokera ku ma ruble a 130 (mapiritsi 60). Uku ndi kuyendera bwino kwa mankhwala akunja, koma sikugwiritsa ntchito. Chifukwa chake, glyformin silingagwiritsidwe ntchito kusunga thanzi la amayi apakati, ana ndi okalamba. Komabe, zotsatira zabwino zimadziwika mu chithandizo cha matenda ashuga ambiri.

Metformin. Mankhwala omwe ali ndi chophatikizira chomwecho m'munsi. Pali opanga angapo: Gideon Richter, Hungary, Teva, Israel, Canonpharma ndi Ozone, Russia. Mtengo wopaka mankhwalawa udzakhala ma ruble 120 ndi zina. Ichi ndiye chiwonetsero chotsika mtengo kwambiri cha Merifatin, chida chotsika mtengo komanso chodalirika.

Glucophage. Awa ndi mapiritsi okhala ndi metformin pamapangidwewo. Wopanga - kampani ya Merck Sante ku France. Mtengo wa mankhwalawo ndi ma ruble 130 ndi zina. Ichi ndi analogue yakunja kwa Merifatin, yomwe ingagulidwe komanso kuchotsera. Amakhala ndi nthawi yochepa komanso yayitali. Zotsutsana ndizokhazikika: mankhwalawa sayenera kuperekedwa kwa ana, amayi oyembekezera komanso okalamba. Ndemanga za mankhwalawa ndizabwino.

Siofor. Mapiritsi awa amatengera metformin. Wopanga - makampani aku Germany a Berlin Chemie ndi Menarini. Mtengo wa ma CD udzakhala ma ruble 200. Zimapezeka pazokonda ndi dongosolo. Zochita zake ndizapakati pakanthawi, zitha kugwiritsidwa ntchito limodzi ndi mankhwala ena. Mndandanda wa zotsutsana ndi muyezo.

Metfogamma. Zomwe zimagwiritsidwa ntchito ndizofanana ndi merifatin. Yopangidwa ndi Werwag Pharm, Germany. Pali mapiritsi ochokera ku ma ruble 200. Izi zikuchitikanso, monganso zoletsa kugwiritsa ntchito. Njira yabwino komanso yotsika mtengo yakunja.

Yang'anani! Kusintha kuchokera ku wina kupita ku mankhwala ena a hypoglycemic kumachitika moyang'aniridwa ndi dokotala. Kudzipatsa nokha koletsedwa!

Makamaka ndemanga za merifatin ndi zabwino. Kuchita bwino, kuthekera kutenga ndi mankhwala ena kumadziwika. Zokhudzana ndi zovuta, odwala amalemba kuti amangoyambira chithandizo, pomwe thupi limazolowera mankhwalawa. Kwa ena, mankhwalawo sioyenera.

Olga: “Ndazindikira kuti ndili ndi matenda ashuga. Ndakhala ndikumuchitira kwa nthawi yayitali, makamaka ndimankhwala omwe ali ndi metformin pakapangidwe. Posachedwa ndidayetsa Merifatin pa upangiri wa dokotala. Ndimakonda zotheka zake. Sichabwino. Ndipo mu mankhwala amapezeka nthawi zonse. Ndiye ndi chida chabwino. ”

Valery: “Ndili ndi matenda ashuga owonjezera kunenepa. Zomwe ndidayesera, kale zakudya sizithandiza. Dokotala adalemba Merifatin, adatinso ziyenera kuthandiza kuchepetsa kunenepa. Ndipo anali kunena zoona. Sikuti ndimangokhala ndi shuga pano, koma ndataya kale ma kilogalamu atatu pamwezi. Kwa ine, izi ndi kupita patsogolo. Chifukwa chake ndimalimbikitsa. ”

Mlingo

mapiritsi a oblong biconvex, oyera-okhala ndi mafilimu oyera okhala ndi ngozi mbali imodzi. Pamtanda, pakati ndi yoyera kapena pafupifupi yoyera.

Piritsi limodzi lili:

Zogwira pophika: metformin hydrochloride 1000 mg.

Omwe amathandizira: hypromellose 2208 10,0 mg, povidone K90 (collidone 90F) 40.0 mg, sodium stearyl fumarate 10,0 mg.

Kanema wamadzi wosungunuka wamadzi: hypromellose 2910 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 1.8 mg, polysorbate 80 (pakati pa 80) 0,2 mg, titanium dioxide 4.0 mg.

Mankhwala

Zotsatira zoyipa

Pafupipafupi zotsatira zoyipa za mankhwalawa zimawerengeredwa motere: pafupipafupi (≥1 / 10), nthawi zambiri (≥1 / 100, 35 kg / m2,

- mbiri ya matenda ashuga,

- mbiri ya banja la anthu odwala matenda ashuga oyambira kale,

- kuchuluka ndende ya triglycerides,

- kuchepa kwa ndende ya HDL cholesterol,

Zotsatira pa kuthekera koyendetsa magalimoto ndi njira:

Monotherapy yokhala ndi metformin siyimayambitsa hypoglycemia chifukwa chake sichikhudza kuthekera koyendetsa magalimoto ndi machitidwe. Komabe, odwala ayenera kuchenjezedwa za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin limodzi ndi mankhwala ena a hypoglycemic (zotumphukira za sulfonylurea, insulin, repaglinide, etc.).

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, omwe samachita bwino pakudya ndi masewera olimbitsa thupi:

- akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa kapena ena ndi insulin,

- mwa ana kuyambira zaka 10 monga monotherapy kapena osakanikirana ndi insulin. Kupewera kwa matenda ashuga amtundu wa 2 odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa matenda a shuga a 2, momwe kusintha kwasinthidwe sikunalole kuti chiwopsezo cha glycemic chikwaniritsidwe.

Mankhwala Merifatin: malangizo ogwiritsira ntchito

Kuti achulukitse kuchuluka kwa shuga m'magazi, mumagwiritsidwa ntchito mankhwala osiyanasiyana, kuphatikizapo Merifatin. Mankhwala a Hypoglycemic ali ndi contraindication ndi zotsatira zoyipa, kotero musanayambe chithandizo, muyenera kukaonana ndi katswiri ndikuphunzira malangizowo.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapezeka mu mawonekedwe a mapiritsi a 500 mg, 850 mg ndi 1000 mg, yokutidwa. Amayikidwa mu zidutswa 10. mu chithuza. Mtolo wa makatoni ukhoza kukhala ndi matuza 1, 2, 3, 4, 5, 6, 8, 9, kapena 10. Mapiritsi amatha kuikidwa mumtsuko wa polymer wa ma 15 ma PC, ma 30 ma PC., Ma 60 ma PC. 100 ma PC. kapena ma PC 120. Chosakaniza chophatikizacho ndi metformin hydrochloride. Zothandiza monga povidone, hypromellose ndi sodium stearyl fumarate. Kanema wamadzi wosungunuka wamadzi amakhala ndi polyethylene glycol, titanium dioxide, hypromellose ndi polysorbate 80.

Ndi chisamaliro

Amamwa mankhwalawa mosamala kwambiri pakuchita opareshoni ndikuvulala kwambiri ngati pakufunika kumwa insulin, kutenga pakati, uchidakwa wambiri kapena poyizoni waukali, kutsatira zakudya zochepa zama calorie, lactic acidosis, komanso ngati asanachitike kapena pambuyo poti a radioisotope kapena x-ray amamuthandizira wodwala wokhala ndi ayodini. .

Pa nthawi yoyembekezera, Merifatin iyenera kumwedwa mosamala kwambiri.

Momwe mungatenge Merifatin?

Chochita chake chimapangidwira kuti azigwiritsa ntchito pakamwa. Mlingo woyambirira panthawi ya monotherapy mwa odwala akuluakulu ndi 500 mg katatu patsiku. Mlingo umatha kusinthidwa kukhala 850 mg 1-2 pa tsiku. Ngati ndi kotheka, mlingo umakulitsidwa kwa 3000 mg kwa masiku 7.

Ana opitirira zaka 10 amaloledwa kutenga 500 mg kapena 850 mg kamodzi patsiku kapena 500 mg kawiri pa tsiku. Mlingo utha kuwonjezeredwa mu sabata mpaka 2 g patsiku la 2-3. Pambuyo masiku 14, adokotala amasintha kuchuluka kwa mankhwalawo, poganizira kuchuluka kwa shuga m'magazi.

Akaphatikizidwa ndi insulin, mlingo wa Merifatin ndi 500-850 mg katatu patsiku.

Matumbo

Kuchokera pagawo logaya chakudya, mseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba komanso kusowa kwa chakudya kumawonedwa. Zizindikiro zosasangalatsa zimachitika koyamba pa chithandizo ndikupita mtsogolo. Kuti musayanjane nawo, ndikofunikira kuti muyambe ndi kuchuluka kochepa ndikuwonjezera pang'onopang'ono.

Kuchita ndi mankhwala ena

Sizoletsedwa kuphatikiza metformin ndi mankhwala okhala ndi ayodini omwe amakhala ndi radiopaque. Mosamala, akutenga Merifatin ndi Danazol, Chlorpromazine, glucocorticosteroids, diuretics, jekeseni wa beta2-adrenergic agonists ndi othandizira antihypertensive, kupatula ngati zoletsa za agiotensin kutembenuza enzyme.

Kuwonjezeka kwa ndende ya metformin m'magazi kumawonedwa panthawi yolumikizana ndi mankhwala a cationic, omwe amiloride. Kuchulukitsidwa kwa metformin kumachitika pakaphatikizidwa ndi nifedipine. Kulera kwa mahomoni kumachepetsa mphamvu ya hypoglycemic ya mankhwala.