TromboMag® (TromboMag)

Mankhwalawa amalepheretsa zochitika za cycloo oxygenase 1 ndi 2, zomwe zimatenga gawo limodzi mu malamulo a kuphatikiza kwa prostaglandin (chifukwa chotupa ndi kupangitsa matenda opweteka).

Mapiritsi a Thrombopol ali ndi analgesic, anti-yotupa, antipyretic.

Gawo logwira ntchito ndilo acetylsalicylic acid.

Kutsika kwa ma prostaglandins mu pachimake amachititsa kutsika kwa kutentha kwa thupi chifukwa cha thukuta lomwe limachulukirachulukira. Zotsatira zapakati komanso zotumphukira za gawo lalikulu, zotsatira za analgesic zimatheka.

Mankhwala amachepetsa ntchito thrombosis chifukwa cha kuponderezedwa kwa kapangidwe ka thromboxane A2 m'magazi am'magazi ndi ma protein. Mankhwala amachepetsa kuphatikiza ndi kuphatikizika kwa mapulosi.

Kukwaniritsidwa mothandizidwa ndi mankhwala Thrombopol (limodzi mlingo) antiplatelet kwenikweni anapulumutsidwa masiku 7. Odwala omwe ali ndi vuto losakhazikika la angina, mankhwalawa amachepetsa chiopsezo cha myocardial infarction, kufa.

Mankhwalawa amagwiritsidwa ntchito kupewera koyambirira komanso kwachiwiri kwa kulowerera kwa myocardial infarction.

Mlingo wa tsiku ndi tsiku wa magalamu 6 umachulukitsa nthawi ya prothrombin, umalepheretsa kaphatikizidwe ka prothrombin mu minofu ya chiwindi.

Mothandizidwa ndi acetylsalicylic acid, kuchuluka kwa zophatikizika kumachepa (2,7,9,10), ntchito ya plasma fibrinolytic imawonjezeka.

Pa opaleshoni ikuchitika, mankhwalawa amawonjezera pafupipafupi zovuta za hemorrhagic, zimawonjezera mwayi wokhetsa magazi.

Mankhwala a Thrombopol amathandizira njira yopangira mafuta uric acid (machitidwe a uric acid reabsorption mu impso asokonezeka).

Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa kuti apumule ululu (ofatsa, pang'ono) ochokera kumayendedwe osiyanasiyana: kupweteka kwa dzino, migraine, mutu, neuralgia, algodismenorea, radicular syndrome, lumbago, myalgia, arthralgia, mutu ndi achire mowa.

Mankhwala amagwiritsidwa ntchito febrile syndrome motsutsana ndi maziko a matenda opatsirana komanso otupa.

Contraindication

Malangizo ogwiritsira ntchito thrombopol samalimbikitsa kupereka mankhwala osalolera acetylsalicylic acid, omwe ali ndi hemorrhagic diathesisKutulutsa magazi m'mimba, kusinthika kwamkamwa ndi zilonda zam'mimba mu gawo lachiwopsezo, ndi mphumu ya bronchial (mawonekedwe omwe amaperekedwa ndi kudya kwa salicylates ndi mankhwala a NSAID), munthawi yomweyo methotrexate pa mlingo wa 15 pa sabata kapena kupitirira.

Mapiritsi a thrombopol sakhazikitsidwa ngati akupaka bere, pomwe mukuyamwitsa. Mankhwalawa amaleredwa mwa ana.

Zotsatira zoyipa

Thrombopol ikhoza kuyambitsa nseru, Reye matenda (chitukuko cha chiwindi kulephera molumikizana ndi pachangu pang'onopang'ono mafuta chiwindi ndi concomitant encephalopathy), matupi awo sagwirizana ndi mawonekedwe a bronchospasm, angioedema zotupa pakhungu), kutsekula m'mimba, kuchepa magazi, thrombocytopenia, gastralgia, kuchepa kwamtima, leukopenia.

Kuchira kwakanthawi kungayambitse kupweteka mutu, chizungulire, magazi, kuchepa kwa magazi, zotupa ndi zotupa zam'mimba zam'mimba, kusanza, bronchospasm, tinnitus, ndi kuchepa kwa kuwona kwa chidwi. yade interstitial, zosokoneza zowoneka, kutupa, kuwonjezeka kwa zizindikiro zakulephera kwa mtima, matenda aseptic meningitisnephrotic syndrome, kulephera kwa impso, papillary necrosis, prerenal azotemia limodzi ndi hypercalcemia ndi hypercreatininemia, kuchuluka kwa chiwindi.

Thrombopol, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Thrombopol imatengedwa pakamwa. Anti-yotupa ndi analgesic zotsatira zimaperekedwa ndi Mlingo wa mankhwala owonjezera 400-500 mg.

Ndikumva ululu ndi matenda a nthomba ndikuyambitsa 0,5-1 magalamu patsiku (3 waukulu).

Njira ya mankhwala sayenera kupitirira 2 milungu. Mlingo umodzi wothandiza mitundu ya mankhwala ndi 0,25-1 magalamu (3-4 Mlingo patsiku).

Bongo

Zizindikiro zosokoneza bongo: kusanza, mseru, kupumira msanga, tinnitus, kumva ndi kuvutika kwam'maso, mutu, kugona. Pa mlingo wa yogwira yoposa 500 mg pa kg, zotsatira zakupha ndizotheka.

Tsuka m'mimba, kusanza, kumwa makala. Simungathe kutenga barbiturates. Palibe mankhwala.

Kuchita

Thrombopol imatha kupititsa patsogolo zotsatira zoyipa methotrexatemuchepetsechilolezo chaimpso.

Mankhwalawa amalimbikitsa mphamvu ya heparin, narcotic analgesics, anticoagulantsothandizira opatsirana, mangasulfonamides.

Acetylsalicylic acid imachepetsa mphamvu ya mankhwala omwe amadya (furosemide, spironalokton), antihypertensive mankhwala, mankhwala a uricosuric(sulfinpyrazone, benzbromarone).

Kukonzekera kwa Ethanol, ethanol palokha glucocorticosteroids onjezerani kuwonongeka kwa mankhwalawa pa khoma la mucous la m'mimba, zomwe zingayambitse magazi m'mimba.

Thrombopol imakulitsa kuchuluka kwa barbiturates, digoxin ndi mchere wa lithiamu m'magazi.

Mafuta amachepetsa ndi munthawi yomweyo maantacid.

Mankhwala a Myelotoxic amalimbikitsa mphamvu ya hematotoxic ya thrombopol.

Malangizo apadera

Njira ya kutenga acetylsalicylic acid kuti mukwaniritse analgesic zotsatira popanda kufunsa dokotala sayenera kupitirira masiku 5.

Thrombopol sinafotokozeredweMatenda oopsa a myocarditisnyamakazi, rheumatism, pericarditis ndi rheumatic chorea.

Mankhwalawa amathetsedwa masiku 5-7 musanayambe kuchitidwa opareshoni.

Kutenga nthawi yayitali kumafunikira kuyeserera kochita zamatsenga pamagazi ndikuwonetsetsa kuwerengera magazi.

Mu ana, kutenga Thrombopol kumatha kuyambitsa matenda a Reye (kuchuluka kwa chiwindi, kukula kwa nthawi yayikulu ya encephalopathy, kusanza, kusanza kosagwirizana).

Munthawi yomweyo mankhwala omwe amachepetsa acidity ya chapamimba madzi, amachepetsa kwambiri kukwiya kwa acetylsalicylic acid pakhoma la mucous m'mimba.

Thrombopol ndichikhalidwe zotsatira za teratogenic (kutsekera koyambirira kwa ductus arteriosus, chikhazikitso cha palate wapamwamba komanso kusintha kwina kwa fetal).

Odwala omwe ali ndi gout, mankhwalawa amatha kuyambitsa kugunda kwamphamvu chifukwa cha kuchepa kwa uric acid excretion mutamwa acetylsalicylic acid.

Kukana kwathunthu kumwa zakumwa zoledzeretsa panthawi yonse ya chithandizo kumafunika.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, maola 1-2 mutatha kudya, 1 nthawi patsiku.

Piritsi yokonzekera TromboMag imamezedwa yonse (imatha kutafunidwa kapena kuphwanyidwa), kutsukidwa ndi madzi.

Mankhwalawa adapangira kuti azigwiritsidwa ntchito kwa nthawi yayitali. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Kupewera koyambirira kwamatenda amtima, monga thrombosis ndi mtima wovuta, pamaso pa zinthu zomwe zingachitike (monga matenda a shuga, Hyperlipidemia, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba)

Patsiku loyamba - piritsi limodzi lokhala ndi 150 mg ya acetylsalicylic acid, ndiye piritsi limodzi la 75 mg la acetylsalicylic acid.

Kupewera kwa myocardial infarction ndi chotupa cha magazi

Piritsi limodzi lokhala ndi 75 mg kapena 150 mg ya acetylsalicylic acid.

Piritsi limodzi lokhala ndi 75 mg kapena 150 mg ya acetylsalicylic acid.

Kupewa kwa thromboembolism pambuyo pakuchita opaleshoni ya mtima (mwachitsanzo, kupanikizika kwa mitsempha yodutsa m'mitsempha, kulumikizana kolimba mtima

Piritsi limodzi lokhala ndi 75 mg kapena 150 mg ya acetylsalicylic acid.

Ngati mukusowa mtundu umodzi kapena zingapo za mankhwala a ThromboMag, muyenera kumwa mankhwalawo omwe mwaphonya akangokumbukira izi. Popewa kumangodandaula kawiri pa mankhwalawa, simuyenera kumwa piritsi yomwe yasowa ngati nthawi yakumwa mlingo wotsatira.

Makhalidwe ochita kuchitikira pakayambitsidwe koyamba kapena kutulutsa mankhwalawa sanawonedwe.

Zotsatira za pharmacological

Makina a antiplatelet zochita za acetylsalicylic acid (ASA) amatengera cholepheretsa kusintha kwa cycloo oxygenase enzyme (COX-1), chifukwa chomwe kapangidwe ka thromboxane A2 chatsekedwa ndipo kuphatikiza kwa mapulateleti kumakanikizidwa.

Mphamvu yothandizira kuphatikiza imatchulidwa kwambiri m'mapulateleti, chifukwa samatha kupanga COX. Amakhulupirira kuti ASA ili ndi njira zina zoponderezera kuphatikizira kwa kupatsidwa zinthu za m'magazi, zomwe zimakulitsa kuchuluka kwake m'matenda osiyanasiyana a mtima. ASA imakhalanso ndi zotsutsa-kutupa, antipyretic ndi analgesic zotsatira.

Magnesium hydroxide - antacid, amachepetsa kukwiya kwa ASA pamimba.

Mimba komanso kuyamwa

Kugwiritsa ntchito salicylates mu Mlingo woyambirira m'nthawi yoyambirira ya mimba kumalumikizidwa ndi kuchuluka kwa zolakwika za fetal (kufalikira kwa chamkati, zolakwika za mtima). Kugwiritsa ntchito mankhwala koyamba nthawi ya mimba kumapangidwa. Munthawi yachiwiri ya mimba, mankhwalawa amatha kuperekedwa poyerekeza kuwunika kwa mitundu ya chithandizo cha mayiyo ndi chiwopsezo cha mwana wosabadwayo, Mlingo wosapitilira 150 mg / tsiku kwakanthawi kochepa. Mu wachitatu trimester ya mimba, salicylates muyezo waukulu (zoposa 300 mg / tsiku) amalepheretsa ntchito, kutsekeka kwakhazikitsidwa kwa arterial duct mu mwana wosabadwayo, kuchuluka magazi mu mayi ndi mwana wosabadwayo, ndipo kugwiritsa ntchito musanabadwe kungayambitse kukha magazi kwakanthawi, makamaka ana akhanda. Kugwiritsa ntchito mankhwalawa mu III trimester ya mimba kumapangidwa.

Ma salicylates ndi ma metabolites awo ochepa amapita mkaka wa m'mawere. Zambiri zamankhwala kuti zitsimikizire chitetezo cha acetylsalicylic acid panthawi yoyamwitsa sizokwanira. Musanalembe acetylsalicylic acid munthawi ya mkaka wa m`mawere, phindu la mankhwala osokoneza bongo ndi chiopsezo cha ana akhanda ziyenera kuyesedwa. Mwadzidzidzi kudya kwa salicylates pa mkaka wa m`mawere sikuyenda limodzi ndi zovuta mu mwana ndipo sikutanthauza kuti kuyamwa yoyamwitsa. Komabe, ngati mukufuna kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, kuyamwitsa kuyenera kuyimitsidwa nthawi yomweyo.

Gulu la Nosological (ICD-10)

Mlingo ndi makonzedwe

Mkati Maola 1-2 atatha kudya, 1 nthawi patsiku.

Piritsi ya TromboMag ® yokonzekera imamezedwa yonse (imatha kutafuna kapena kuphwanya), kutsukidwa ndi madzi.

Mankhwala TromboMag ® adapangidwira kuti azigwiritsa ntchito nthawi yayitali. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Kupewera koyambirira kwamatenda amtima, monga thrombosis ndi mtima wovuta, pamaso pa zinthu zomwe zingachitike (monga matenda a shuga, Hyperlipidemia, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba). Tsiku loyamba - 1 tebulo. Kukonzekera kwa ThromboMag ® komwe kuli 150 mg ya acetylsalicylic acid, ndiye - tebulo limodzi. ThromboMag ® yokhala ndi 75 mg ya acetylsalicylic acid.

Kupewa mobwerezabwereza myocardial infarction ndi mtsempha wamagazi thrombosis. 1 tabu. ThromboMag ® yokhala ndi 75 kapena 150 mg ya acetylsalicylic acid.

Angina pectoris. 1 tabu. ThromboMag ® yokhala ndi 75 kapena 150 mg ya acetylsalicylic acid.

Kupewa kwa thromboembolism pambuyo pakuchita opaleshoni ya mtima (mwachitsanzo, kupanikizika kwa mitsempha yodutsa m'mitsempha, kupanikizika kolimba kwa coronary angioplasty). 1 tabu. ThromboMag ® yokhala ndi 75 kapena 150 mg ya acetylsalicylic acid.

Mukadumpha muyezo umodzi kapena zingapo za kukonzekera kwa TromboMag ®, ndikofunikira kumwa mlingo womwe mwaphonya wodwala akangokumbukira izi. Popewa kumangodandaula kawiri pa mankhwalawa, simuyenera kumwa piritsi yomwe yasowa ngati nthawi yakumwa mlingo wotsatira.

Makhalidwe ochita kuchitikira pakayambitsidwe koyamba kapena kutulutsa mankhwalawa sanawonedwe.

Kutulutsa Fomu

Mapiritsi okhala ndi mafilimu 75 mg + 15.2 mg kapena 150 mg + 30.39 mg. 10 tabu. mu matuza matuza opangidwa ndi zojambulazo za aluminium zojambulazo ndi zojambulazo, zojambula za PVC ndi film ya polyamide. Matuza atatu kapena 10 amaikidwa pakatoni.

Wopanga

Hemofarm LLC, Russia. 249030, Dera la Kaluga, Obninsk, Kievskoye sh., 62.

Tele.: (48439) 90-500, fakisi: (48439) 90-525.

Tchulani ndi adilesi ya bungwe lalamulo lomwe satifiketi yolembetsa / bungwe lovomera zonena zawo yatulutsidwa. Nizhpharm JSC, Russia, 603950, Nizhny Novgorod, GSP-459, ul. Salgan, 7.

Foni: (831) 278-80-88, fakisi: (831) 430-72-28.

Pharmacokinetics

Kamodzi m'matumbo am'mimba, ASA imatengedwa mwachangu komanso pafupifupi kwathunthu. Ndi kulowetsa munthawi yomweyo, mayamwidwe amachepetsa. Imakhala ndi kagayidwe kakang'ono panthawi yoyamwa.

Pakumizidwa komanso pambuyo pake, ASA imapangidwira biotransformed mu metabolite yayikulu - salicylic acid, yomwe imapangidwanso motsogozedwa ndi enzyme (makamaka m'chiwindi), zomwe zimapangitsa kupangika kwa metabolites monga salicylic acid, glucuronide salicylate ndi phenyl salicylate, yomwe imapezeka m'madzi ambiri amthupi komanso zimakhala. Mwa akazi, ASA metabolism imayamba kuchepa (chifukwa cha kuchepa kwa ma enzymes mu seramu).

Kuchuluka kwa plasma ndende ya ASA kumafika patangotha ​​mphindi 10 - 20 mutatenga ThromboMag pakamwa, salicylic acid - pambuyo 18-120 mphindi. Acetylsalicylic ndi salicylic acids amamangika kwambiri mpaka mapuloteni a plasma ndipo amagawidwa mwachangu mthupi. Kumangiriza kwa salicylic acid kuma protein a plasma sikuli mzere ndipo kumatengera ndende. Pazinthu zotsika kwambiri (0.4 mg / ml) - mpaka 75%.

The bioavailability wa acetylsalicylic acid ndi 50-68%, salicylic acid - 80-100%. Salicylic acid imadutsa chotchinga ndi kulowa mkaka wa m'mawere.

Mwa makanda, amayi oyembekezera, komanso odwala omwe amalephera impso, ma salicylates amatha kuchotsa bilirubin kuyanjana ndi albumin ndikupangitsa kukula kwa bilirubin encephalopathy.

ASA ndi metabolites ake amuchotsa makamaka ndi impso. Mukamatenga ThromboMag mu Mlingo wotsika, theka-moyo (T_½) plasma acetylsalicylic acid ndi 1520 min, salicylic acid ndi 120-180 min. Mukamamwa mankhwala kwambiri Mlingo chifukwa cha machulukitsidwe a enzymatic machitidwe T_½ kuchuluka kwambiri.

Mosiyana ndi ma salicylates ena, ASA yopanda hydrolyzed, pamene imatengedwa mobwerezabwereza, siziunjikira mu seramu yamagazi. Ndi matenda abwinobwino aimpso, 80-100% ya mlingo wolandilidwa wa ASA umachotsedwa ndi impso mkati mwa maola 24-72.

Ma hydroxide omwe ndi gawo la ThromboMag magnesium samakhudza bioavailability wa ASA.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya antiplatelet ya ASA imachepetsedwa ndi: colestyramine, ibuprofen, systemic glucocorticosteroids ndi ma antacid okhala ndi magnesium ndi / kapena aluminium hydroxide.

ASA imawonjezera vutoli ndikuwonjezera chiopsezo cha poizoni mukamagwiritsa ntchito munthawi yomweyo ndi methotrexate (kuchepetsa kutsekeka kwa impso ndikuyichotsa kumapuloteni a m'madzi a m'magazi) ndi valproic acid (ndikuyichotsa mu mapuloteni a plasma).

Monga ma NSAID ena, mu Mlingo wambiri, ASA imatha kuchepetsa kukhudzika kwa okodzetsa (kuletsa kaphatikizidwe ka mankhwala a impso prostaglandins ndikuchepetsa kuchuluka kwa kusefera kwa glomerular) ndi mankhwala a antihypertensive. Makamaka, chifukwa cha mpikisano wothamangitsa kuphatikizika kwa prostacyclin, mankhwalawa amatha kuchepetsa zotsatira za angiotensin kutembenuza ma enzyme (ACE) zoletsa.

Mlingo wocheperako, ASA imafooketsa mphamvu ya uricosuric agents (sulfinpyrazone, probenecid, benzbromarone), motsutsana kupewetsa aimpso mucular excretion wa uric acid.

ASA imawonjezera vutoli ndikuwonjezera chiopsezo cha zotsatirapo za mankhwala otsatirawa:

• ma NSAID ena ndi ma analgesics a narcotic (chifukwa cha mgwirizano wamachitidwe),
• carbonic anhydrase inhibitors, mwachitsanzo, acetazolamide (kukula kwa acidosis yowonjezereka komanso kuwonjezereka kwa zovuta m'magazi amkati amanjenje kumatha),
• digoxin ndi lithiamu (impso zawo zimachepa, kuchuluka kwa plasma kumawonjezera, kutsata kwa plasma kuyenera kuyang'aniridwa ndikuwongolera kwa mankhwala ofunikira),
• kusankha serotonin reuptake inhibitors, kuphatikizapo paroxetine ndi sertraline (chifukwa cha synergistic kanthu, ndi chiopsezo chowonjezereka cha magazi m'matumbo am'mimba),
• antiplatelet agents (kuphatikiza clopidogrel ndi dipyridamole), anticoagulants osadziwika (kuphatikiza ticlopidine ndi warfarin), heparin, mankhwala a thrombolytic (chifukwa cha kutsika kwa mapuloteni a plasma ndi synergism ya zotsatira zazikulu zochizira),
• m`kamwa hypoglycemic wothandizila, amene amatuluka sulfonylurea, ndi insulin ASA muyezo waukulu tsiku lililonse (oposa 2000 mg) lokha ali ndi hypoglycemic katundu, komanso amachotsa sulfonylurea zotengera kulumikizana ndi mapuloteni a plasma,
• sulfonamides, kuphatikiza co-trimoxazole (ASA imawachotsera kulumikizana ndi mapuloteni a plasma ndikuwonjezera kuchuluka kwa plasma yamagazi),
• ethanol (kuwonongeka kwake kwa mucous nembanemba kwam'mimba kumalimbikitsidwa, ndipo chiopsezo chotaya magazi m'mimba chimakulanso).

Ma Analogs a ThromboMag ndi: Cardiomagnyl, Thrombital, Thrombital Forte, Phasostabil.

Zizindikiro zamankhwala

Prophylaxis yoyamba ya mtima matenda monga thrombosis ndi pachimake mtima kulephera ndi chiopsezo (mwachitsanzo matenda ashuga, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba), kupewa myocardial infarction ndi magazi chotupa, kupewa thromboembolism pambuyo pa opaleshoni mtima kulowerera (coronary artery bypass grafting, percutaneous translate coronary angioplasty), wosakhazikika angina pectoris.

Mlingo

Mankhwalawa amatengedwa pakamwa, pakatha maola awiri kuchokera pakudya, 1 nthawi / tsiku. Mapiritsi amayenera kumeza lonse ndi madzi. Ngati angafune, piritsiyo imathyoledwa pakati, kutafuna kapena pre-nthaka.

Mankhwalawa adapangira kuti azigwiritsidwa ntchito kwa nthawi yayitali. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala.

Pochotsetsa matenda oyamba a mtima monga matenda a mtima komanso matenda a mtima pachimake pakachitika zinthu zoopsa (mwachitsanzo, matenda ashuga, matenda oopsa, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba), 1 tabu. The mankhwala okhala acetylsalicylic acid muyezo wa 150 mg tsiku loyamba, ndiye 1 tabu. The mankhwala okhala acetylsalicylic acid mu 75 mg 1 nthawi / tsiku.

Pofuna kupewa pafupipafupi myocardial infarction ndi magazi chotupa thrombosis, 1 t. Mankhwala okhala ndi acetylsalicylic acid muyezo wa 75-150 mg 1 nthawi / tsiku.

Pofuna kupewa thromboembolism pambuyo opaleshoni yamatumbo (coronary artery bypass grafting, percutaneous translateuminal coronary angioplasty) yoika 1 tabu. Mankhwala okhala ndi acetylsalicylic acid muyezo wa 75-150 mg 1 nthawi / tsiku.

Ndiina wosakhazikika, 1 tabu. Mankhwala okhala ndi acetylsalicylic acid muyezo wa 75-150 mg 1 nthawi / tsiku.

Ngati mwaphonya mtundu umodzi kapena zingapo za mankhwalawa, muyenera kumwa mankhwalawo omwe mwaphonya mankhwala akangokukumbukira. Popewa kumangodandaula kawiri pa mankhwalawa, simuyenera kumwa piritsi yomwe yasowa ngati nthawi yakumwa mlingo wotsatira.

Zodabwitsa za chochitika cha mankhwala poyambirira kapena kusiya kwa mankhwalawa sizinawoneke.

Zotsatira zoyipa

Mwambiri, kukonzekera kokhala ndi kuphatikiza uku kumavomerezeka.

Kuchokera kwamanjenje: kawirikawiri - kupweteka mutu, kusowa tulo, kawirikawiri - chizungulire, kugona, kawirikawiri - tinnitus, intracerebral hemorrhage.

Kuchokera ku hemopoietic dongosolo: pafupipafupi - magazi ochulukirapo, kawirikawiri - kuchepa magazi, osowa - aplastic anemia, hypoprothrombinemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, agranulocytosis. Pali malipoti a milandu ya hemolysis ndi hemolytic anemia mwa odwala kwambiri glucose-6-phosphate dehydrogenase.

Kuchokera pakupuma dongosolo: nthawi zambiri - bronchospasm.

Kuchokera pamimba yokhudza kugaya chakudya: pafupipafupi - kutentha kwa mtima, kusanza, kusanza, kupweteka kwam'mimba, zilonda zam'mimba zam'mimba ndi zotupa zam'mimba, magazi am'mimba, osowa - kufukiza kwa zilonda zam'mimba kapena zilonda zam'mimba, kuchuluka kwa michere ya chiwindi , osowa kwambiri - stomatitis, esophagitis, zotupa za chapamwamba pamatumbo (kuphatikiza ndi ziwopsezo), colitis, matumbo osakwiya.

Thupi lawo siligwirizana: pafupipafupi - urticaria, edema wa Quincke, zotupa pakhungu, kuyabwa, rhinitis, kutupira kwammphuno, kawirikawiri - anaphylactic mantha, matenda a mtima.

Zina: kawirikawiri kwambiri - kuwonongeka kwaimpso.