Augmentin wa ana - nditha kumwa mankhwala liti ndipo ndingatani?

Chonde, musanagule Augmentin, kuyimitsidwa 200 mg + 28,5 mg / 5 ml, botolo 70 ml, yang'anani zambiri za nkhaniyi ndi zomwe zili patsamba lawebusayiti la wopangiralo kapena tchulani mtundu wa mtundu winawake ndi woyang'anira kampani yathu!

Zomwe zikuwonetsedwa patsamba lino sizoperekedwa pagulu. Wopanga amakhala ndi ufulu wosintha kapangidwe kake, kapangidwe kake ndi katayidwe kake ka zinthu. Zithunzi zamalonda pazithunzi zomwe zaperekedwa pamndandanda wazomwe zili patsamba lino zimasiyana ndi zomwe zidachokera.

Zambiri pamutengo wa zinthu zomwe zawonetsedwa pamndandanda wazomwe zili patsamba lino zitha kusiyana ndi zomwe zimachitika panthawi yokhazikitsa dongosolo la zomwe zikugwirizana.

Wopanga

5 ml ya kuyimitsidwa komwe kuli:

Mphamvu yogwira: amoxicillin (mu mawonekedwe a trihydrate) - 200 mg, clavulanic acid (monga mchere wa potaziyamu) - 28,5 mg.

Omwe amathandizira: xanthan chingamu - 12,5 mg, aspartame - 12.5 mg, presinic acid - 0,84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 79.65 mg, kukoma kwa lalanje 1 - 15 mg, kukoma kwa lalanje 2 - 11.25 mg, kukoma kwa rasipiberi - 22,5 mg, Kuwala kwa manyuchi - 23,75 mg, silicon dioxide - mpaka 552 mg.

Zotsatira za pharmacological

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi β-lactamases, chifukwa chake zochitika za amoxicillin sizingofikira ku tizilombo tating'onoting'ono timene timatulutsa enzymeyi.

Clavulanic acid, β-lactamase inhibitor yokhudzana ndi penicillin, amatha kupanga ma act lactamase osiyanasiyana opezeka mu penicillin ndi cephalosporin zosagwira tizilombo.

Clavulanic acid imagwira mokwanira motsutsana ndi plasmid β-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal β-lactamases ya mtundu 1 yomwe sikuletsedwa ndi clavulanic acid.

Kukhalapo kwa clavulanic acid mu kukonzekera kwa Augmentin® kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - β-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Otsatirawa ndi ntchito ya vitro yosakanikirana ya amoxicillin ndi clavulanic acid.

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Ma gror-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pyogenes1,2, Streptococcus agalactiae1,2, Streptococcus spp. (beta hemolytic streptococci) 1,2, Staphylococcus aureus (wokhudzidwa ndi methicillin) 1, Staphylococcus saprophyticus (wogwira methicillin), Staphylococcus spp. (coagulase-hasi, amakhudzidwa ndi methicillin).

Ma gror-negative aerobes: Bordetella pertussis, Haemophilus influenzae1, Helicobacter pylori, Moraxella catarrhalis1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Enanso: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Ma anaerobes a gram-positive: Clostridium spp., Peptococcus niger, Peplostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.

Gram-negative anaerobes: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Gram-negative aerobes: Escherichia coli1, Klebsiella oxytoca, Klebsiella pneumoniae1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Ma gror-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae1,2, Streptococcus group Viridans2.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-hasi aerobes: Acinetobacter spp.

Ena: Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

1 - mwa mitundu iyi ya tizilombo tating'onoting'ono, kufunikira kwa zamankhwala kosakanikirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 - mitundu ya mabakiteriya amtunduwu samatulutsa β-lactamases. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Bacteria matenda oyambitsidwa ndi tizilombo tating'ono ta mankhwala:

• Zofooka zam'mimba zopumira komanso ziwalo za ENT (mwachitsanzo, tenillitisitis, sinusitis, atitis media), zomwe nthawi zambiri zimayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogene,
• Matenda ochepetsa kupuma am'mimba: kufalikira kwamatenda a bronchitis, ziphuphu za m'mimba ndi bronchopneumonia, omwe nthawi zambiri amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae * ndi Moraxella catarrhalis * (kupatula mapiritsi 250 mg / 125 mg),
• Matenda a urogenital thirakiti: cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli *), Staphylococcus saprophyticus ndi mitundu ya genoc Enterococcus,
• Gonorrhea wochititsidwa ndi Neisseria gonorrhoeae * (kupatula mapiritsi a 250 mg / 125 mg),
• Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, Streptococcus pyogenes ndi mitundu ya mtundu wa Bacteroides *,
• Matenda a mafupa ndi mafupa: osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, ngati kuli kotheka,
• Matenda a Odontogenic, mwachitsanzo, periodontitis, odontogenic, maxillary sinusitis, zotupa zamano kwambiri ndi kufalitsa kwa cellulite (mapiritsi 500 mg / 125 mg kapena 875 mg / 125 mg),
• Matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg).

- - Oimira pawokha a mtundu wina wa tizilombo tating'onoting'ono timatulutsa β-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin.

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Augmentin® imasonyezedwanso zochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhudza amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa β-lactamase, tcheru ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Mimba komanso kuyamwa

Mu maphunziro a kubereka mu nyama, pakamwa komanso mwa uchembere wa Augmentin ® sizinayambitse zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matuza kusanachitike, anapezeka kuti mankhwala a prophylactic amatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis akhanda. Monga mankhwala onse, Augmentin® siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati, pokhapokha ngati phindu lomwe mayi akuyembekezera limaposa chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin® angagwiritsidwe ntchito poyamwitsa. Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amakhudzana ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa. Pamavuto amakumana ndi makanda omwe akuyamwitsa, ndikofunikira kusiya kuyamwitsa.

Contraindication

• Hypersensitivity kwa amoxicillin, clavulanic acid, magawo ena a mankhwala, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis.
• Zolemba zam'mbuyomu za jaundice kapena chiwindi chovuta pantchito mukamagwiritsa ntchito amoxicillin wokhala ndi clavulanic acid m'mbiri.
• Ana ochepera zaka 12 zakubadwa komanso kulemera kwa thupi zosakwana 40 makilogalamu (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg).
• Ana a zaka mpaka miyezi itatu (ufa wopangira kuyimitsidwa kwa kuyamwa kwamlomo wa 200 mg / 28,5 mg ndi 400 mg / 57 mg).
• Kulephera kwamkati (CC ≤ 30 ml / min) - (mapiritsi 875 mg / 125 mg, pa ufa woyimitsidwa pakumwa kwamlomo 200 mg / 28,5 mg ndi 400 mg / 57 mg).
• Phenylketonuria (wa ufa pakuyimitsa pakamwa).

Chenjezo: Kuwonongeka kwa chiwindi.

Zotsatira zoyipa

Zochitika zoyipa zomwe zaperekedwa pansipa zalembedwa malinga ndi kuwonongeka kwa ziwalo ndi ziwalo zamagulu ndi pafupipafupi zomwe zimachitika. Pafupipafupi zomwe zimachitika zimatsimikiziridwa motere: pafupipafupi (≥1 / 10), nthawi zambiri (≥ 1/100,

Magulu amtundu wa pafupipafupi adakhazikitsidwa pamaziko a maphunziro azachipatala a zamankhwala ndi kulembetsa pambuyo pa kulembetsa.

Matenda opatsirana komanso ma parasitic: nthawi zambiri - candidiasis a pakhungu ndi mucous nembanemba.

Pa gawo la magazi ndi dongosolo la lymphatic: kawirikawiri - kusinthika kwa leukopenia (kuphatikizapo neutropenia) ndi kusintha kosinthika kwa magazi, osowa kwambiri - kusintha kwa agranulocytosis komanso kusinthika kwa hemolytic anemia, kuchuluka kwa prothrombin nthawi ndi nthawi ya magazi, kuchepa magazi, eosinophilia, thrombocytosis.

Kuchokera ku chitetezo chamthupi: kawirikawiri - angioedema, anaphylactic zimachitika, ndi vuto lofanana ndi seramu matenda, vasculitis.

Kuchokera kwamitsempha yamitsempha: chizungulire - chizungulire, kupweteka mutu, kawirikawiri - kusinthanso mphamvu, kupweteka (kupweteka) kumachitika mwa odwala omwe ali ndi vuto laimpso, komanso mwa omwe amalandira kuchuluka kwa mankhwalawa), kusowa tulo, kukhumudwa, nkhawa, kusintha kwa machitidwe .

Kuchokera pamimba yodyetsera: akulu: pafupipafupi - kutsegula m'mimba, kusanza, kusanza, ana - pafupipafupi - kutsegula m'mimba, kusanza, kusanza, anthu onse: nseru zimadziwika kwambiri akamamwa mankhwala ambiri. Ngati mutayamba kumwa mankhwalawa pakakhala zovuta zina pamimba, amatha kutha ngati mumwa mankhwalawa koyambirira kwa chakudya. Nthawi zambiri - zovuta zakudya zam'mimba, kawirikawiri - ma colitis omwe amagwiritsidwa ntchito ndi ma antibayotiki omwe amayambitsidwa ndi kumwa ma antibayotiki (kuphatikizapo pseudomembranous colitis ndi hemorrhagic colitis), "lilime" lakuda, gastritis, stomatitis. Ana, mukamagwiritsa ntchito kuyimitsidwa, kusinthasintha kwa mawonekedwe a mano a enamel kumachitika kawirikawiri. Kusamalira pakamwa kumathandiza kuti musawononge mano a mano, chifukwa ndikokwanira kutsuka mano.

Kuchokera ku chiwindi ndi njira ya biliary: pafupipafupi - kuwonjezeka kwapang'onopang'ono kwa ntchito ya ACTi / kapena ALT (yowonetsedwa mwa odwala omwe amalandila beta-lactam antiotic mankhwala, koma tanthauzo lake lamankhwala silidziwika), kawirikawiri - hepatitis ndi cholestatic jaundice (zochitika izi zimadziwika panthawi ya mankhwala a penicillin ndi cephalosporins), kuchulukitsa kwa kuchuluka kwa bilirubin ndi alkaline phosphatase. Zochitika zoyipa kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo amatha kuyanjana ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.

Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa. Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali anthu omwe anali ndi vuto lalitali kapena omwe amamwa nthawi yomweyo mankhwala a hepatotoxic.

Pa khungu ndi subcutaneous zimakhala: pafupipafupi - zidzolo, kuyabwa, urticaria, kawirikawiri - erythema multiforme, kawirikawiri - Stevens-Johnson syndrome, poyizoni epermatitis necrolysis, waukali exfoliative dermatitis, pachimake otchuka exantmatous pustulosis.

Ngati khungu lanu siligwirizana, chithandizo ndi Augmentin® ziyenera kusiyidwa.

Kuchokera impso ndi kwamikodzo thirakiti: kawirikawiri - kwapakati - nephritis, crystalluria, hematuria.

Kuchita

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin® ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake, munthawi yomweyo kugwiritsa ntchito mankhwalawa Augmentin ® ndi phenenecide kungayambitse kuchuluka komanso kulimbikira kwamphamvu ya magazi a amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol. Penicillins amatha kuchepetsa mayankho a methotrexate kuchokera m'thupi popewa kubisalira kwake, chifukwa chake, kugwiritsa ntchito nthawi imodzi kwa Augmentin ® ndi methotrexate kungakulitse kuchuluka kwa methotrexate.

Monga mankhwala ena a antibacterial, Augmentin® ikhoza kukhudza microflora yamatumbo, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Mabukuwa amafotokoza zochitika zapafupipafupi za kuchuluka kwa anthu wamba mothandizirana ndi acenocoumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, makonzedwe omwewo a Augmentin ® pokonzekera ndi anticoagulants, nthawi ya prothrombin kapena MHO iyenera kuyang'aniridwa mosamala mukamayambitsa kapena kuletsa kukonzekera kwa Augmentin®; kusintha kwa antactagulants pakamwa kungafunike.

Momwe mungatenge, njira ya makonzedwe ndi kumwa

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin® imalimbikitsidwa kuti iziyamwa kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Akuluakulu ndi ana opitirira zaka 12 kapena masekeli 40 kapena kupitilira

Piritsi limodzi la 250 mg / 125 mg katatu / tsiku (la matenda ofatsa pang'ono kapena pang'ono), kapena piritsi limodzi la 500 mg / 125 mg katatu kapena tsiku, kapena piritsi limodzi la 875 mg / 125 mg katatu / tsiku, kapena 11 ml ya kuyimitsidwa kwa 400 mg / 57 mg / 5 ml 2 nthawi / tsiku (lofanana ndi piritsi limodzi la 875 mg / 125 mg).

Mapiritsi awiri a 250 mg / 125 mg siofanana ndi piritsi limodzi la 500 mg / 125 mg.

Ana kuyambira miyezi itatu mpaka 12 wazakudya zolemera thupi zosakwana 40 kg

Mankhwalawa adapangidwira mu mawonekedwe a kuyimitsidwa pakamwa.

Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mu mg / kg thupi / tsiku (kuwerengera malinga ndi amoxicillin) kapena ml ya kuyimitsidwa.

Kuchulukitsa kwa kuyimitsidwa kwa 125 mg / 31.25 mg mu 5 ml - katatu kapena tsiku lililonse maola 8 aliwonse

Kuchulukitsa kwa kuyimitsidwa 200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml - 2 kawiri / tsiku lililonse maola 12.

Mlingo woyeserera komanso kuchuluka kwa makonzedwe amaperekedwa pansipa:

Kuchulukitsa kuvomerezeka - katatu kapena tsiku, kuyimitsidwa 4: 1 (125 mg / 31.25 mg mu 5 ml):

• Mlingo wotsika - 20 mg / kg / tsiku.
• Mlingo waukulu - 40 mg / kg / tsiku.

Kuchulukana kwa makonzedwe - 2 nthawi / tsiku, kuyimitsidwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml):

• Mlingo wotsika - 25 mg / kg / tsiku.
• Mlingo waukulu - 45 mg / kg / tsiku.

Mlingo wocheperako wa Augmentin ® umagwiritsidwa ntchito pochiza matenda amkhungu ndi minyewa yofewa, komanso matendawa.

Mlingo waukulu wa Augmentin ® umagwiritsidwa ntchito pochiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma ndimatumbo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsa ntchito mankhwalawa Augmentin® muyezo wa 40 mg / kg / tsiku m'miyeso itatu yogawanika (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu

Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Kugwiritsa ntchito kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) sikulimbikitsidwa pagulu lino.

Ana asanakwane

Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Odwala okalamba

Palibe kusintha kwa mlingo komwe kumafunikira. Okalamba odwala mkhutu aimpso ntchito, mlingo uyenera kusinthidwa motere kwa akuluakulu omwe ali ndi vuto laimpso.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umachitika poganizira mfundo za QC.

Mapiritsi 250 mg + 125 mg kapena 500 mg + 125 mg:

• KK> 30 ml / min - kukonza kwa regimen sikofunikira.
• KK 10-30 ml / mphindi - 1 tabu. 250 mg + 125 mg 2 nthawi / tsiku kapena 1 tabu. 500 mg + 125 mg (kwa matenda ofatsa pang'ono) kawiri / tsiku.
• QC

Kuyimitsidwa 4: 1 (125 mg / 31.25 mg mu 5 ml):

• KK> 30 ml / min - kukonza kwa regimen sikofunikira.
• KK 10-30 ml / mphindi - 15 mg / 3.75 mg / kg 2 kawiri / tsiku, mlingo waukulu ndi 500 mg / 125 mg 2 nthawi / tsiku.
• QC

Mapiritsi a 875 mg + 125 mg ndi kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) akuyenera kugwiritsidwa ntchito mwa odwala CC> 30 ml / min, osasintha mlingo zofunika.

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa.

Odwala a hememalysis

Kusintha kwa mankhwalawa kutengera mlingo woyenera wa amoxicillin: 2 t. 250 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena 1 tabo. 500 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena kuyimitsidwa pa mlingo wa 15 mg / 3.75 mg / kg 1 nthawi / tsiku.

Mapale: panthawi ya hemodialysis gawo, muyeso 1 wa piritsi (piritsi limodzi) ndi 1 piritsi (piritsi limodzi) kumapeto kwa gawo la dialysis (kulipiritsa kuchepa kwa seramu yozungulira amo amoillin ndi clavulanic acid).

Kuyimitsidwa: isanachitike gawo la hemodialysis, mlingo umodzi wowonjezera wa 15 mg / 3.75 mg / kg uyenera kuperekedwa. Kubwezeretsa ndende ya magawo a mankhwala a Augmentin® m'magazi, muyeso wachiwiri wa 15 mg / 3.75 mg / kg uyenera kuyambitsidwa pambuyo pa gawo la hemodialysis.

Odwala omwe ali ndi vuto la chiwindi

Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti ikonzere kuchuluka kwa odwala mu gulu ili.

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Kuyimitsidwa (125 mg / 31.25 mg mu 5 ml): pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afunditse kutentha kwa chipinda akuyenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivundikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti onetsetsani kuswana kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa kukonzekera kwa Augmentin® ukhoza kuchepetsedwa pakati ndi madzi.

Kuyimitsidwa (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml): onjezani pafupifupi 40 ml ya madzi owiritsa ozizira kuti asungunuke m'chipinda cha botolo la ufa, ndiye kutseka kapu ya botolo ndikugwedezeka mpaka ufa utatha Lolani vial kuyimirira kwa mphindi 5 kuti muwonetsetsetsetsetse kuti mwatsuka. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 64 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwalawa, gwiritsani ntchito kapu kapena syringe yoyenera, yomwe imayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana ochepera zaka ziwiri, muyezo umodzi wokha wa kuyimitsidwa kwa kukonzekera kwa Augmentin® akhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Bongo

Zizindikiro: Zizindikiro zam'mimba komanso kusowa kwa madzi m'magetsi kumatha kuchitika.Amoxicillin crystalluria akufotokozedwa, nthawi zina kumabweretsa kukula kwa aimpso.

Convulsions amatha kuchitika kwa odwala mkhutu aimpso ntchito, komanso kwa iwo omwe amalandira kuchuluka kwa mankhwalawa.

Chithandizo: Zizindikiro zam'mimba - chidziwitso cha mankhwala, kulabadira makamaka kutulutsa bwino zamagetsi am'madzi. Ngati bongo, amoxicillin ndi clavulanic acid amatha kuchotsedwa m'magazi ndi hemodialysis.

Zotsatira za kafukufuku woyembekezeredwa yemwe adachitika ndi ana 51 kumalo operekera poizoni adawonetsa kuti kuyang'anira amoxicillin pamlingo wochepera 250 mg / kg sizinachititse kuti pakhale ndi zidziwitso zazikulu zakuchipatala ndipo sizinafune kuti pakhale chiphuphu.

Malangizo apadera

Musanayambe chithandizo ndi Augmentin ®, ndikofunikira kusaka mbiri yakale yokhudzana ndi zam'mbuyomu zomwe zimapangitsa kuti penicillins, cephalosporins kapena allergen ena azigwira.

Zowopsa, ndipo nthawi zina zakupha, hypersensitivity reaction (anaphylactic reaction) ku penicillins amafotokozedwa. Chiwopsezo chotere chimakhala chokwanira kwambiri kwa odwala omwe ali ndi mbiri ya hypersensitivity reaction ku penicillins. Ngati thupi siligwirizana, ndikofunikira kusiya mankhwala ndi Augmentin ® ndikuyamba njira zina zoyenera. Pankhani ya vuto lalikulu la hypersensitivity, epinephrine iyenera kutumikiridwa nthawi yomweyo. Thandizo la okosijeni, iv makonzedwe a GCS ndi kuperekedwa kwa airway patency, kuphatikizapo intubation, ingafunikenso.

Kukhazikitsidwa kwa mankhwalawa Augmentin® sikulimbikitsidwa pa milandu ya mononukpeosis yemwe akuwoneka kuti ali ndi vuto, chifukwa odwala omwe ali ndi matendawa amoxillin amatha kuyambitsa matenda opatsirana ngati chikuku, omwe amachititsa kuti azindikire matendawa.

Kuchiza kwa nthawi yayitali ndi Augmentin® nthawi zina kumabweretsa kubalanso kwakukulu kwa tizilombo tating'onoting'ono.

Mwambiri, Augmentin® imalekeredwa bwino ndipo ili ndi poizoni wambiri wa ma penicillin onse.

Pa chithandizo cha nthawi yayitali ndi Augmentin®, tikulimbikitsidwa kuti nthawi ndi nthawi tiziona ntchito ya impso, chiwindi ndi magazi.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya.

Odwala omwe amalandila amoxicillin ndi clavulanic acid limodzi ndi ma anticoagulants osalunjika, nthawi zina, kuchuluka kwa prothrombin nthawi (kuwonjezeka kwa MHO) kunanenedwa. Ndi kuphatikiza molunjika kwa anticoagulants osalunjika (pakamwa) osakanikirana a amoxicillin ndi clavulanic acid, kuyang'anira zisonyezo ndikofunikira. Kusungitsa kufunika kwa anticoagulants pakamwa, kusintha kwa mlingo kungafunike.

Odwala omwe ali ndi vuto la impso, mlingo wa Augmentin® uyenera kuchepetsedwa molingana ndi kufooka.

Odwala ndi kuchepetsedwa diuresis, nthawi zina, chitukuko cha crystalluria chimanenedwa, makamaka ndi kugwiritsidwa ntchito kwa mankhwala ndi ababa. Munthawi ya makonzedwe apamwamba a amoxicillin, tikulimbikitsidwa kuti timwe madzi okwanira ndikukhala ndi diursis yokwanira kuti muchepetse mapangidwe a makhwala a amoxicillin.

Kumwa mankhwalawa Augmentin ® mkati kumabweretsa zambiri mu amoxicillin mu mkodzo, zomwe zingayambitse zotsatira zabodza pakutsimikiza kwa shuga mumkodzo (mwachitsanzo, mayeso a Benedict, mayeso a Fel). Poterepa, tikulimbikitsidwa kugwiritsa ntchito njira ya glucose oxidant pofufuza kuchuluka kwa shuga mumkodzo.

Kusamalira pakamwa kumathandiza kuti mano asatulutsidwe, popeza kutsuka mano ndikokwanira.

Mapiritsi ayenera kugwiritsidwa ntchito mkati mwa masiku 30 kuyambira pomwe mutsegule phukusi la lameled aluminium.

Kuzunza ndi kudalira mankhwala osokoneza bongo

Palibe kudalira mankhwala, mankhwala osokoneza bongo komanso kusinthasintha kwakukhudzana ndi kugwiritsa ntchito mankhwalawa Augmentin®.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Popeza mankhwalawa angayambitse chizungulire, ndikofunikira kuchenjeza odwala za kusamala poyendetsa kapena kugwiritsa ntchito makina osunthira.

Kodi ndi mitundu ingati ya mankhwala a Augmentin?

Maantimentotic a Augmentin amatanthauza kuphatikiza kapangidwe kazomwe amapanga ndi ma antibacterial othandizira a gulu la penicillin. Mulinso:

• amoxicillin thunthu,
• potaziyamu clavulanate (clavulanic acid).

Mankhwalawa amapezeka m'mitundu ingapo ya mankhwala: ufa wa jakisoni, mapiritsi, madzi ndi mankhwala owuma pokonzekera kuyimitsidwa. Ana osakwana zaka 12 amafunsira madzi kapena kuyimitsidwa. Mitunduyi imalekeredwa bwino ngakhale ndi ana, komabe, sizingatheke kupatula kwathunthu kuyambika kwa thupi lawo siligwirizana. Mfundoyi iyenera kukumbukiridwa popereka mankhwala kwa ana (onani momwe thupi limayankhira pambuyo poyambira yoyamba).

Augmentin - zikuonetsa kwa ana

Gwiritsani ntchito mankhwalawa molingana ndi mankhwala omwe mumalandira. Dokotala wa ana akuwonetsa kuchuluka, kuchuluka kwa mankhwalawa Augmentin, zomwe zikuwonetsa kugwiritsa ntchito zomwe ndi izi:

• matenda opatsirana a kumtunda kwa kupuma thirakiti, kuphatikizapo matenda a khutu, mmero ndi mphuno (sinusitis, tonsillitis, otitis media),
• kwambiri yotupa njira mu ziwalo za kupuma dongosolo - lobar chibayo, bronchopneumonia,
• matenda a kwamikodzo - urethritis, pyelonephritis, cystitis,
• matenda a pakhungu ndi minofu yofewa,
• matenda opatsirana m'mafupa.

Augmentin - zotsutsana

Mankhwalawa amalekeredwa bwino ndi ana, koma sangathe kugwiritsidwa ntchito nthawi zonse. Madokotala amaganizira izi popereka Augmentin kwa ana, zotsutsana zomwe zimagwiritsidwa ntchito motere:

• Hypersensitivity pamagawo a mankhwala,
• penicillin antiotic tsankho,
• kukhalapo kwa episode wa jaundice motsutsana ndi momwe amagwiritsidwira ntchito kale kuphatikiza kwa amoxicillin ndi clavulanic acid.

Komanso, ndikofunikira kuwonetsa mosiyana mitundu iliyonse ya mankhwala:

• Mapiritsi a 250 mg ndi zambiri saikidwa kwa ana osaposa zaka 12 okhala ndi thupi lochepera 40 kg,
• ufa wa kuyimitsidwa umaphatikizidwa mu makanda mpaka miyezi 3 ndi ana omwe ali ndi phenylketonuria.

Augmentin wa ana, kuyimitsidwa - mlingo

Kulemba Augmentin, momwe mungawerengere mankhwalawa kwa mwanayo - adokotala amafotokozera mwatsatanetsatane mayi. Mlingo umawerengeredwa payekhapayekha ndipo zimatengera mtundu wa matenda, gawo la momwe mungagwiritsire ntchito matenda, zaka ndi kulemera kwa mwana. Mukamawerengera kuchuluka kwa mankhwala, zomwe zili mu amoxicillin sodium zimawerengedwa - kuchuluka kwa zosakaniza ndi mankhwala enaake. Kwa Augmentin, akuwonetsedwa pamapaketi ndi botolo limodzi ndi mankhwala (mg mg).

Augmentin 125, kuyimitsidwa - Mlingo wa ana

Pamene kuyimitsidwa kwa Augmentin kukhazikitsidwa, mlingo wa ana wakhazikitsidwa poganizira kulemera kwa thupi la mwana. Izi ndi gawo lalikulu posankha kuchuluka kwa ma antibacterial othandizira. Ndizofunikira kudziwa kuti pa msinkhu womwewo, ana amatha kukhala ndi zolemera zosiyanasiyana, kotero, kuperekedwa kwa mankhwalawa kutengera zaka sizolondola. Mu ndende iyi, Augmentin amagwiritsidwa ntchito kwa ana aang'ono. Kuwerengera kwa mankhwalawa kuli motere:

• ana osakwana chaka chimodzi (kulemera kwa thupi 2-5 makilogalamu) - 1.5-2.5 ml katatu pa tsiku,
• makanda wazaka 1 mpaka 5 (6- makilogalamu) - 5 ml katatu patsiku,
• Ana azaka 6 - 9 (19-27 makilogalamu) - 15 ml katatu patsiku,
• ana wazaka 10-12 (29-39 makilogalamu) - 20 ml katatu patsiku.

Augmentin 200, kuyimitsidwa - Mlingo wa ana

Augmentin 200 ya ana ndi Mlingo wamba. Mu ndende iyi, mankhwalawa amatha kuperekedwa kwa makanda. Kuphatikizika kwakukulu kwa zinthu zomwe zimagwiritsidwa ntchito kumatha kuchepetsa kuchuluka kwa mankhwalawa. Mukamapereka mankhwala a Augmentin 200, mulingo wa ana amawerengedwa motere:

• makanda mpaka 1 chaka - 1.5-2.5 ml kawiri pa tsiku,
• ana 1-5 zaka - 5 ml ya kuyimitsidwa 2 pa tsiku,
• Ana wazaka 6 - 9 - 2 ml kawiri pa tsiku.

Augmentin 400 - mlingo wa ana

Mlingo woyenera wa Augmentin 400 (kuyimitsidwa kwa ana) amagwiritsidwa ntchito pochiza ana okalamba. Nthawi yomweyo, kufunika kogwiritsa ntchito mankhwalawa kumachepetsedwa - kumaperekedwa kawiri pa tsiku pambuyo pa maola 12. Popereka Augmentin kwa ana 400, madokotala amalimbikitsa kutsatira zotsatirazi:

• Ana azaka za 6-9 - 7.5 ml ya kuyimitsidwa,
• pa zaka 10 - 10 ml 2 kawiri pa tsiku.

Momwe mungaperekere Augmentin kwa ana?

Pokambirana za momwe mungatengere Augmentin kwa ana, madokotala a ana amawunika chidwi chofuna kutsatira kwambiri mankhwala. Asanagwiritse ntchito, ufa umasungunuka ndi kuchuluka kwa madzi (madzi owiritsa). Kuti zitheke, zilembo za botolo la Augmentin za ana zili ndi chizindikiro choti ziyenera kudzazidwa ndi madzi. Pambuyo pake, pakani zolimba ndikusakaniza mankhwalawo, ndikuwugwedeza kwa mphindi ziwiri.

Amatenga mankhwala a Augmentin a ana molingana ndi malangizo azachipatala. Kuti mupewe dosing yosavuta, gwiritsani ntchito chipewa choyeza chomwe chimabwera ndi zida, kapena syringe. Kuti muchepetse kukhumudwitsa kwa mankhwalawa pa mucosa wam'mimba, mankhwalawa amaperekedwa kwa mwana kwa mphindi zochepa asanadye. Mukatha kugwiritsa ntchito mankhwalawo, chikho choyezera chimatsukidwa bwino, chowuma ndikugwiritsanso ntchito.

Augmentin - zotsatira zoyipa mwa ana

Kuyimitsidwa kwa ana Augmentin nthawi zina kumatha kuyambitsa mavuto. Akawonekera, mankhwalawa amaletsedwa, ndipo adokotala adauzidwa zomwe zidachitika. Ndi zovuta zoyipa za Augmentin, m'malo mwa mankhwalawa mungafunike. Mwa izi, titha kusiyanitsa:

• kuwonongeka kwa chakudya cham'mimba (cham'mimba, kutsegula m'mimba, kunyansidwa ndi kusanza),
• kusokonezeka kwa chitetezo chathupi - thupi lawo siligwirizana,
• kuphwanya kwamkati dongosolo - mapangidwe magazi,
• kuwonongeka kwa chiwindi - chiwindi,
• kukhumudwa kwa chapakati mantha dongosolo - mutu, chizungulire, kupweteka,
• matenda a pakhungu - erythema, kuyabwa.

Kodi chingalowe m'malo ndi chiyani cha Augmentin

Mopanda kulekerera bwino mankhwala a Augmentin kwa ana, chitukuko cha zomwe zimachitika kuchokera mthupi laling'ono kupita kukamwa kwake, amayi nthawi zambiri amaganiza zomwe Augmentin amatha kusintha. Chiwerengero chachikulu cha analogu chimaperekedwa pamsika wamafuta, motero zimakhala zosavuta kusankha mankhwala oyenera kwa mwana. Pankhaniyi, ndikofunikira kutsatira malangizo omwe adalandira kuchokera kwa dokotala yemwe adachitapo chithandizo:

1. Werengani malangizowo.
2. Ganizirani zaka za mwana.
3. Onani kuchuluka ndi kuchuluka kwa mankhwalawa.
4. Mwa kusintha konse kwa mwana, auzeni adotolo.

Mwa mankhwala omwe ali ndi amoxicillin omwe amagwiritsidwa ntchito pochiza ana, nthawi zambiri amalembedwa:

• Amoxiclavkviktab,
• Amoxil-k
• Zoopercin,
• Camox Clave
• Amoxiplus,
• Baktoklav,
• Vampilox.

Augmentin (kuyimitsidwa, mapiritsi, ufa) - mtengo

Mtengo wamitundu yosiyanasiyana ya Augmentin m'masitolo am'mizinda ya Russia umasiyana pamitundu iyi:

• Augmentin ufa pokonzekera kuyimitsidwa kwa ma ruble a 125 / 31.25 - 118 - 161,
• Augmentin ufa wokonzekera kuyimitsidwa kwa ma ruble 200 / 28,5 - 126 - 169,
• Augmentin ufa wokonzekera kuyimitsidwa 400/57 - 240 - 291 rubles,
• Augmentin EU ufa pokonzekera kuyimitsidwa kwa ma ruble a 600 / 42.9 - 387 - 469,
• Mapiritsi 250/125, zidutswa 20 - ma ruble 246-301,
• Mapiritsi 875/125, zidutswa 14 - 334 - 430 rubles,
• Mapiritsi a Augmentin SR 1000 / 62,5, zidutswa 28 - 656 - 674 rubles,
• Ufa wa yankho la jakisoni 1000/2007 - 1797 - 2030 rubles.

Augmentin pa nthawi yoyembekezera

Mu maphunziro a ntchito za kubereka mu nyama, makamwa ndi utsogoleri wa Augmentin® sizinayambitse zovuta za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matendawa zisanachitike, anapezeka kuti mankhwala a prophylactic ndi Augmentin® akhoza kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mwa akhanda.

Monga mankhwala ena onse, Augmentin® siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati, pokhapokha ngati phindu lomwe mayi akuyembekezera limaposa chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin® angagwiritsidwe ntchito poyamwitsa.Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amakhudzana ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa.

Monga maantibayotiki ambiri a gulu la penicillin, amoxicillin, woperekedwa m'matupi a thupi, umalowanso mkaka wa m'mawere. Komanso, tsatanetsatane wa clavulanic acid amatha kupezeka mkaka.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza kwa clavulanic acid ndi amoxicillin kumatha kuyambitsa matenda otsegula m'mimba komanso / kapena candidiasis (thrush) ya mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zomwe zimagwira mu Augmentin zimatha kulowa mu zotchinga za hemato-placental (GPB). Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kumatha kubweretsa kukula kwa necrotizing enterocolitis (NEC) khanda lobadwa chatsopano.

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Mlingo wa Augmentin (kwa akulu ndi ana)

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo musanadye.

Choyamba, zimapereka kuyamwa kwabwino kwa zinthu zomwe zimagwira m'matumbo awo, ndipo, chachiwiri, zimachepetsa kwambiri kuvutika kwa zovuta m'matumbo, ngati zimachitika.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso mankhwalawa ochizira, kutengera momwe mankhwalawa amathandizira, momwe akumvera zotsatira za maantibayotiki, kuopsa kwa mawonekedwe a matendawa, kuchuluka kwa matenda, zaka ndi kulemera kwa wodwala komanso momwe impso za wodwala wake zilili.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg 125 mg) - kamodzi katatu patsiku. Mlingo uwu, mankhwalawa akuwonetsedwa kumatenda omwe amapezeka ofatsa kapena ochepa kwambiri. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi 625 mg (500 mg 125 mg) - kamodzi katatu patsiku.
• Mapiritsi 1000 mg (875 mg 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto laimpso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Kwa odwala omwe ali ndi matenda a impso, mankhwalawa amaperekedwa pokhapokha ngati phindu la Reberg limaposa 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo sizikufunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa odwala omwe ali ndi zovuta - maora asanu ndi limodzi kapena anayi alionse (malinga ndi zofunikira).

Maantibayotiki mu njira ya yankho la 500 mg / 100 mg kapena 1000 mg / 200 mg amalembedwa kuti ateteze kukula kwa matenda opatsirana pambuyo pakuchita opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kukhazikitsa mlingo wa Augmentin 1000 mg / 200 mg kwa wodwala kamodzi musanachitike opaleshoni.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Mpaka pano, mankhwalawa mu mitundu yosiyanasiyana ya mankhwala ndi amodzi mwa omwe amadziwika kwambiri pochiza matenda a tonsillitis.

Ana Augmentin ndi angina amalembedwa muyezo, womwe umatsimikiziridwa potengera kulemera kwa thupi ndi msinkhu wa mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin 875 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin ndi sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsitsi yamkati monga Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku. Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana, maantibayotiki nthawi zambiri amawalembera angina. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg 125 mg katatu patsiku,
• piritsi limodzi 500 125 mg kawiri pa tsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo.Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Analogues a Augmentin, omwe ali m'malo mwake monga mankhwala, ndi Amoksiklav, Flemoklav Solyutab, Arlet, Rapiklav, Ekoklav.

Mtundu uliwonse wa Augmentin uli ndi mitundu iwiri yogwira - amoxicillin ndi clavulanic acid, kotero, kuchuluka kwa mankhwalawa sikuwonetsedwa ndi nambala imodzi, koma ndi awiri, mwachitsanzo, 400 mg 57 mg, etc.

Chifukwa chake, Augmentin mu mawonekedwe a ufa pokonzekera yankho la jakisoni amapezeka mu Mlingo wa 500 mg 100 mg ndi 1000 mg 200 mg. Izi zikutanthauza kuti mutatha kupaka phula ndi madzi, yankho limapezeka lomwe lili ndi 500 mg kapena 1000 mg ya amoxicillin ndipo, motero, 100 mg ndi 200 mg ya clavulanic acid.

M'moyo watsiku ndi tsiku, mitundu iyi ya mankhwalawa imangotchulidwa kuti "Augmentin 500" ndi "Augmentin 1000", pogwiritsa ntchito chithunzi chosonyeza zomwe zili amoillillin ndikusiya kuchuluka kwa clavulanic acid.

Augmentin mu mawonekedwe a ufa pokonzekera kuyimitsidwa pakamwa pakamwa amapezeka mwanjira zitatu: 125 mg 31.25 mg pa 5 ml, 200 mg 28,5 mg pa 5 ml ndi 400 mg 57 mg pa 5 ml.

M'moyo watsiku ndi tsiku, magawidwe a kuchuluka kwa clavulanic acid nthawi zambiri samasiyidwa, ndipo ndizomwe zimapangidwa amoxicillin zokha, popeza kuwerengera kwa mankhwalawa kumachitika makamaka chifukwa cha antiotic.

Popeza Augmentin woyimitsidwa amagwiritsidwa ntchito mwa ana osakwana zaka 12, nthawi zambiri amatchedwa "ana a Augmentin." Chifukwa chake, Mlingo wa kuyimitsidwa umatchedwa khanda. M'malo mwake, Mlingo wa kuyimitsidwa uku ndi wofanana ndipo ungagwiritsidwe ntchito bwino kwa akuluakulu omwe ali ndi thupi lozama, koma chifukwa chogwiritsa ntchito kwambiri mankhwalawa kwa ana, amatchedwa ana.

Augmentin EC amapezeka mu mawonekedwe a ufa pokonzekera kuyimitsidwa mu gawo limodzi - 600 mg 42.9 mg pa 5 ml. Izi zikutanthauza kuti 5 ml ya kuyimitsidwa komwe kumakhala muli 600 mg ya amoxicillin ndi 42.9 mg ya clavulanic acid.

Augmentin SR imapezeka mu mawonekedwe a piritsi limodzi ndi gawo limodzi la zinthu zomwe zimagwira - 1000 mg 62,5 mg. Izi zikutanthauza kuti piritsi limodzi lili ndi 1000 mg ya amoxicillin ndi 62,5 mg wa clavulanic acid.

Kufotokozera za mtundu wa kipimo

Ufa: yoyera kapena pafupifupi yoyera, yokhala ndi fungo labwino. Ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi koyera kumapangidwa. Poimirira, yoyera kapena yoyera imayamba pang'onopang'ono.

Mapiritsi, 250 mg 125 mg: filimu yokutira kuchokera kuyera mpaka pafupi kuyera, mawonekedwe owumbika, ndikulembedwa "AUGMENTIN" mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mapiritsi, 500 mg 125 mg: filimu yokutira kuyambira yoyera mpaka pafupi yoyera, yoloweka mawonekedwe, yolembedwa "AC" komanso chiopsezo kumbali imodzi.

Mapiritsi, 875 mg 125 mg: filimu yokutira kuchokera kuzoyera mpaka pafupifupi zoyera, chowulungika, chokhala ndi zilembo "A" ndi "C" mbali zonse ziwiri ndi mzere wolakwika mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Ndemanga za Augmentin

Pafupifupi 80 - 85% ya ndemanga za Augmentin ndi zabwino, zomwe zimachitika chifukwa cha luso la mankhwalawa pochiza matenda mwa anthu. Pafupifupi ndemanga zonse, anthu amawonetsa kugwiritsidwa ntchito bwino kwa mankhwalawa, chifukwa chake pamakhala chithandizo chamatenda opatsirana.

Komabe, pamodzi ndi mawu akuti Augmentin amagwira ntchito bwino, anthu amawonetsa kukhalapo kwa zoyipa zomwe sizinali zosasangalatsa kapena zolekerera bwino. Kunali kupezeka kwa zoyambitsa zomwe zinali zoyambira 15 - 20% ya ndemanga zoyipa zomwe zatsala ngakhale kuti mankhwalawo anali ogwira ntchito.

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin ndizabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin omwe amasiya ndi ana a ana ang'ono akuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana pafupipafupi monga bronchitis kapena tonillitis. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Zizindikiro zogwiritsidwa ntchito

Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muchepetse kusokonezeka kwa m'mimba ndikuwonjezera kuyamwa, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya. Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita stepwise mankhwala (woyamba kholo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Tiyenera kukumbukira kuti 2 tabu. Augmentin®, 250 mg 125 mg siofanana ndi piritsi limodzi. Augmentin®, 500 mg 125 mg.

Akuluakulu ndi ana azaka 12 kapena kupitirira kapena masekeli 40 kapena kupitilira. Ndikulimbikitsidwa kugwiritsa ntchito 11 ml ya kuyimitsidwa pamlingo wa 400 mg 57 mg mu 5 ml, wofanana ndi tebulo limodzi. Augmentin®, 875 mg 125 mg.

1 tabu. 250 mg 125 mg katatu pa tsiku kwa matenda ofatsa kwambiri. Mu matenda opweteka kwambiri (kuphatikiza matenda amkati komanso obwereza kwamkodzo, matenda oyamba ndi kupuma kwaposachedwa), mankhwala ena a Augmentin® amalimbikitsidwa.

1 tabu. 500 mg 125 mg katatu pa tsiku.

1 tabu. 875 mg 125 mg kawiri pa tsiku.

Ana a zaka zitatu mpaka zaka 12 okhala ndi thupi lochepera 40 makilogalamu. Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mg / kg / tsiku kapena ml ya kuyimitsidwa. Mlingo wa tsiku ndi tsiku umagawidwa pakudya katatu pakatha maola 8 aliwonse (125 mg 31.25 mg) kapena 2 pa maola aliwonse 12 (200 mg 28,5 mg, 400 mg 57 mg). Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Malangizo a Augmentin® dosing (mawerengedwa a kuchuluka kwa amoxicillin)

Mlingo wocheperako wa Augmentin ® umalimbikitsidwa pochizira matenda amkhungu ndi minofu yofewa, komanso matendawo.

Mlingo wapamwamba wa Augmentin ® umalimbikitsidwa pochizira matenda monga otitis media, sinusitis, matenda am'munsi kupuma ndi kwamkodzo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsa ntchito mankhwalawa Augmentin® muyezo wa 40 mg 10 mg / kg mu 3% ya mgawo (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu. Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Makanda obadwa asanakwane. Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Magulu apadera a odwala

Odwala okalamba. Malangizo a mtundu wa mankhwalawa safunikira; Okalamba odwala mkhutu aimpso ntchito, Mlingo woyenera amamulembera odwala omwe ali ndi vuto laimpso.

Odwala omwe ali ndi vuto la chiwindi. Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti musinthe malangizowo mwa odwala.

Odwala ndi mkhutu aimpso ntchito.Kuwongolera kwa dongosolo la mankhwalawa kumadalira kuchuluka kwa mlingo wovomerezeka wa amoxicillin ndi kufunika kwa chiwonetsero cha ntchito.

Malangizo a Augmentin®

Jakisoni wa Augmentin amasonyezedwanso kupewa ndi kuchiza matenda omwe angayambike pambuyo pakuchitidwa opaleshoni yayikulu m'matumbo am'mimba, pelvis, mutu, khosi, impso, mu opaleshoni yamtima, komanso pambuyo podziwikitsidwa kwa ma cell a ziwalo zam'mimba.

Zisonyezero zogwiritsidwa ntchito Suspension Augmentin EU ndi chithandizo chanthawi yochepa chabe mwa matenda otsatirawa omwe amabwera chifukwa cha ma virus apakhungu:

• Zowonjezera kapena zowawa za otitis media,
• Tonsillopharyngitis,
• Sinusitis
• Chibayo cham'mimba ndi bronchopneumonia,
• Matenda a pakhungu ndi minofu yofewa (cellulitis, abscess, phlegmon, zithupsa, panniculitis, mabala opatsirana).

Zisonyezero zakugwiritsa ntchito mapiritsi Augmentin SR ndi chithandizo chanthawi yochepa chabe mwa matenda otsatirawa omwe amabwera ndi mabakiteriya omwe amamva ma antiotic:

• Chibayo si chipatala
• Kuchulukitsa kwa matenda opindika,
• Pachimake bakiteriya sinusitis,
• Kupewa matenda opatsirana pambuyo mano.

Mapiritsi amayenera kumezedwa kwathunthu, osafuna kutafuna, osaluma komanso osaphwanya mwanjira ina iliyonse, koma kutsukidwa ndi pang'ono

Musanatenge kuyimitsidwa, yeretsani kuchuluka komwe mukufunikira pogwiritsa ntchito kapu yoyesera kapena syringe yokhala ndi zilembo. Kuyimitsidwa kumatengedwa pakamwa, kumeza muyeso wofunikira kuchokera mwachindunji.

Ana omwe pazifukwa zina sangathe kumwa kuyimitsidwa koyera, ndikofunikira kuti azithira ndi madzi muyezo wa 1: 1, atatsanulira gawo loyenera kuchokera ku kapu yoyesera mu kapu kapena chidebe china. Mukatha kugwiritsa ntchito, chophimba kapena syringe iyenera kupukutidwa ndi madzi oyera.

Pofuna kuchepetsa kusokonezeka komanso zoyipa kuchokera m'mimba, timalimbikitsidwa kumwa mapiritsi ndi kuyimitsidwa koyambirira kwa chakudya. Komabe, ngati izi sizingatheke pazifukwa zilizonse, ndiye kuti mapiritsi amatha kumwa nthawi iliyonse pokhudzana ndi chakudya, popeza chakudya sichimakhudza kwambiri zotsatira za mankhwalawo.

Jakisoni wa Augmentin amaperekedwa kokha m'mitsempha. Mutha kubaya jet yankho (kuchokera pa syringe) kapena kulowetsedwa ("dontho"). Mgwirizano wamankhwala osokoneza bongo saloledwa! Njira yothetsera jakisoni imakonzedwa kuchokera ku ufa nthawi yomweyo isanakonzedwe ndipo siisungidwa ngakhale mufiriji.

Kukhazikika kwa mapiritsi ndi kuyimitsidwa, komanso kukhazikika kwa yankho la Augmentin, kuyenera kuchitika pafupipafupi. Mwachitsanzo, ngati mukufunika kumwa mankhwalawa kawiri patsiku, ndiye kuti mukuyenera kukhalabe ndi nthawi yofananira ndi maola 12 pakati pa mulingo.

Zotsatira zochizira

Augmentin ali ndi njira imodzi yothandizira - antibacterial, popeza imakhala yovulaza pamitundu ingapo ya tizilombo tating'onoting'ono tomwe timayambitsa matenda opatsirana komanso otupa a genitourinary and kupuma thirakiti.

minofu yam'mimba, komanso osteomyelitis,

. Ndiye kuti, Augmentin amawononga mabakiteriya omwe amayambitsa matenda a ziwalozi, motero, amachiritsa matenda opatsirana komanso otupa.

Kupezeka kwa clavulanic acid ku Augmentin kumapangitsa kuti mankhwalawa akhale othandiza kwambiri, chifukwa amakupatsani mwayi wokuwonjezera zochita za amoxicillin ndikuwugwira mtima motsutsana ndi mabakiteriya, omwe, akakhala padera, amagwiritsa ntchito antibayotiki.

Tulutsani mafomu, mitundu ndi mayina a Augmentin

Mitundu yonse itatu iyi ya Augmentin ndi mitundu yogulitsa ya antibayotiki yomweyo yofanana ndi mawonekedwe, zikuwonetsa ndi malamulo ogwiritsira ntchito.

Kusiyana kokhako pakati pa mitundu yamalonda ya Augmentin ndi kuchuluka kwa chinthu chogwira ntchito ndi mawonekedwe omasulidwa (mapiritsi, kuyimitsidwa, ufa wothandizira jakisoni).

Kusiyanaku kumakulolani kuti musankhe mtundu wabwino kwambiri wa mankhwalawo pamilandu iliyonse. Mwachitsanzo, ngati munthu wamkulu pazifukwa zina sangathe kumeza mapiritsi a Augmentin, amatha kugwiritsa ntchito kuyimitsidwa kwa Augmentin EU, etc.

Nthawi zambiri, mitundu yonse ya mankhwalawa imangotchedwa "Augmentin", ndikufotokozera momveka bwino tanthauzo lake, amangowonjezera dzina la mawonekedwe ndi Mlingo, mwachitsanzo, kuyimitsidwa kwa Augmentin 200, mapiritsi a Augmentin 875, etc.

Zosiyanasiyana za Augmentin zimapezeka mu mitundu yotsatsira iyi: 1. Augmentin:

• Mapiritsi amlomo
• Mphamvu yakuyimitsidwa pakamwa
• Ufa wa yankho la jakisoni.

• Mphamvu ya kuyimitsidwa pakamwa.

• Mapiritsi osinthidwa amasinthidwe okhala ndi nthawi yayitali.

M'moyo watsiku ndi tsiku, popanga mitundu ndi mitundu yosiyanasiyana ya Augmentin, kagwiritsidwe ntchito ka njira mofupikitsidwa, komwe kumakhala mawu akuti "Augmentin" ndi chisonyezo cha mtundu kapena mlingo, mwachitsanzo, kuyimitsidwa kwa Augmentin, Augmentin 400, ndi zina zambiri.

Mtengo wa Augmentin

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake. Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo woyimitsidwa wa Augmentin wa ana: 400 mg / 57 mg (Augmentin 2) - 65 UAH, 200 mg / 28,5 mg - 59 UAH, 600 mg / 42.9 mg - 86 UAH.

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti mutsimikizire kuchepetsedwa kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa.

Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito.Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin akhoza kuchepetsedwa pakati ndi madzi.

Gwiritsani ntchito pa nthawi yoyembekezera

Augmentin angagwiritsidwe ntchito ndi amayi panthawi yomwe akubala mwana milandu yomwe cholinga chake chimapindulitsa kwa mayi kuposa chiopsezo cha mwana wosabadwayo.

Augmentin angagwiritsidwe ntchito poyamwitsa. Zikachitika kuti kumwa mankhwalawo kumathandizira kuti pakhale zovuta zina mwa mwana, nkhani yosiya kuyamwitsa iyenera kuganiziridwa.

Zotsatira zoyipa

Augmentin angathandizire kukulitsa zoyipa zosafunikira izi:

• Candidiasis a mucous nembanemba ndi khungu.
• Kutsegula m'mimba, kunyansidwa komanso kusanza.
• Mutu, chizungulire.
• Khungu loyera, urticaria, zotupa.

Ndi chitukuko cha thupi lawo siligwirizana, mankhwalawa Augmentin yomweyo anasiya.

Ndikofunikira kudziwitsa dokotala za zomwe zimapangitsa kuti mukhale ndi zotsatirapo zoyipa kuti muthe kusintha kapena kusankhira mtundu wa mankhwala.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin® ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake, munthawi yomweyo kugwiritsa ntchito mankhwalawa Augmentin ® ndi phenenecide kungayambitse kuchuluka komanso kulimbikira kwamphamvu ya magazi a amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol. Penicillins amatha kuchepetsa mayankho a methotrexate m'thupi popewa kubisalira kwake, kotero kugwiritsa ntchito nthawi yomweyo kwa Augmentin ® ndi methotrexate kungakulitse kuchuluka kwa methotrexate.

Monga mankhwala ena a antibacterial, Augmentin® ikhoza kukhudza microflora yamatumbo, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Mabukuwa amafotokoza zochitika zapafupipafupi za kuchuluka kwa anthu wamba padziko lonse lapansi (INR) mwa odwala omwe amaphatikizana ndi acenocoumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, makonzedwe omwewo a Augmentin® kukonzekera ndi anticoagulants, nthawi ya prothrombin kapena INR iyenera kuyang'aniridwa mosamala mukamapereka kapena kusiya kukonzekera kwa Augmentin®) kusintha kwa mankhwala a anticoagulants pakamwa kungafunike.

Odwala omwe amalandila mycophenolate mofetil, atayamba kugwiritsa ntchito mankhwala osakanikirana a amoxicillin ndi clavulanic acid, kuchepa kwa ndende yogwira metabolic, mycophenolic acid, adawonedwa asanamwe mlingo wotsatira wa mankhwalawa pafupifupi 50%. Zosintha pamawonekedwe awa sizingawonetse moyenera kusintha kwamtundu wa mycophenolic acid.

Malangizo apadera

Asanayambe kugwiritsa ntchito Augmentin, wodwala wodwalayo ayenera kudziwa zomwe zimachitika mu penicillin, cephalosporin ndi zina.

Kuyimitsidwa kwa Augmentin kumatha kusokoneza mano a wodwalayo. Popewa kukula kwa zoterezi, ndikokwanira kutsatira malamulo oyambira aukhondo - kupukuta mano, kugwiritsa ntchito misempha.

Kuvomerezedwa Augmentin kungayambitse chizungulire, kotero, pakakhala nthawi yayitali, sayenera kuyendetsa magalimoto ndikuchita ntchito yomwe imafuna chidwi chachikulu.

Augmentin sangagwiritsidwe ntchito ngati mtundu wopatsirana wa mononucleosis ukayikiridwa.

Augmentin amakhala wololera bwino komanso wowopsa. Ngati kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, ndikofunikira kuti muwone momwe impso ndi chiwindi zimagwirira ntchito.

Kutulutsa Fomu

Wopanga mankhwalawa ndi kampani yaku Britain a Smith Kline Beecham PLC.Augmentin amapezeka m'njira zosiyanasiyana, zomwe ndi zoyenera kwa akulu ndi ana omwe. Izi ndi:

• mapiritsi
• mapiritsi otulutsidwa
• ufa woyimitsidwa
• ufa pakukonzekera njira yothandizira makolo (kulowetsedwa kapena kulowetsedwa kwa mankhwala).

Nthawi zambiri, Augmentin monga mapiritsi amagwiritsidwa ntchito pakukalamba. Amatha kukhala ndi zosankha zotsatirazi (mg amooticillin + mg clavulanic acid):

Mapiritsi a Augmentin amakhalanso ndi ambiri omwe amapezeka:

• magnesium wakuba,
• sodium carboxymethyl wowuma,
• silika
• microcrystalline mapadi.

Zoyimitsidwa zimapezekanso m'malo osiyanasiyana (400, 200 ndi 125 mg ya amoxicillin pa 5 ml).

Ufa pakukonzekera njira yothetsera mtsempha wama khosi ukupezeka mu Mlingo wa 1000 ndi 500 mg wa amoxicillin.

Augmentin amapezeka ku malo ogulitsa mankhwala.

Pharmacokinetics ndi pharmacodynamics

Mukamamwa pakamwa, mapiritsiwo amamufikitsa mwachangu m'magazi kuchokera m'matumbo. Maola ochepa mutatenga Augmentin, kuchuluka kwa ziwalo zake m'magazi kumafikira pazambiri. Amagawanidwa mokwanira m'matumba onse amadzimadzi ndi thupi (mapapu, m'mimba, adipose, minofu ndi mafupa.) Kuphatikizika kwofananira kwa amoxicillin kumapereka njira yothandizira komanso yosatha. Amoxicillin amathandizidwa kudzera mu impso za wodwalayo, acid ya clavulanic imapukusidwa ndi impso komanso njira zina zowonjezera.

Augmentin amatchulidwa ngati mbali zosiyanasiyana za thupi zakhala ndi matenda opatsirana:

• misewu yotsika ndi mapapu
• chapamwamba kupuma thirakiti
• khungu ndi minofu yofewa (Staphylococcus aureus ndi mitundu ina ya mabakiteriya),
• ziwalo zoberekera ndi maliseche,
• mafupa ndi mafupa
• mano ndi mkamwa.

Amoxicillin akulimbikitsidwa matenda otsatirawa kupuma:

Matenda a kwamikodzo ndi ziwalo, komwe madokotala nthawi zambiri amamulembera Augmentin:

Augmentin akulimbikitsidwa nthawi zina:

• periodontitis
• chotupa mano
• sepsis (postpartum, intraabdominal),
• kuchotsa mimba kwa septic.

Augmentin amalimbikitsidwanso kupewa matenda pakanthawi kogwiritsa ntchito ndi kuyikirana kwa zinthu zina.

Kugwiritsa ntchito mankhwalawa panthawi yapakati komanso poyamwitsa

Amayi ambiri omwe ali ndiudindo kapena wokhala ndi ana ali ndi chidwi ndifunsoli, kodi ndizotheka kugwiritsa ntchito mankhwalawa muzochitika zotere? Yankho lomveka bwino pa chiwerengerochi mulibe, kuphatikiza pamalangizo. Dokotala yemwe amathandizira matenda omwe ali ndi kachilombo mwa mayi wapakati amayenera kuyesa zabwino ndi zovuta zake, kenako atamulembera Augmentin. Zigawo za mankhwala zimatha kulowa mkaka wa m'mawere kudzera mu zotchinga za placental. Komabe, chidziwitso kuti chitha kuvulaza mwana kulibe. Kuphatikiza apo, matenda omwe ali mthupi la mayi amatha kupweteketsa mwana kwambiri kuposa Augmentin.

Augmentin, malangizo ogwiritsira ntchito

Augmentin ayenera kumwedwa kokha monga adokotala adalembera, mankhwala omwe amadzipaka nokha ndi mankhwala othandizira sakuvomerezeka, makamaka ngati mwana akudwala. Mlingo wovomerezeka wa Augmentin mu mawonekedwe a mapiritsi pokhapokha ngati wodwala ali ndi vuto lalikulu ndi 250 + 125 g katatu patsiku. Mokulira kwambiri, mapiritsi a 500 + 125 g amawayika katatu patsiku. Kapena mutha kumwa mapiritsi awiri a Augmentin 875 + 125 g patsiku.

Tiyenera kukumbukira kuti Augmentin iyenera kutengedwa mosamalitsa komanso nthawi yofanana. Chifukwa, mwachitsanzo, ngati mankhwalawa amatchulidwa katatu patsiku, ayenera kumwedwa nthawi iliyonse. Ngati mukufuna kumwa mapiritsi 2 kawiri pa tsiku, ndiye kuti muyenera kuchita izi maola 12 aliwonse. Njira yofananayo imakuthandizani kuti muzikhala ndi nthawi zonse yogwiritsa ntchito mankhwalawa m'thupi lathu.

Malangizo ogwiritsira ntchito kuyimitsidwa kwa ana ndi akulu

Ana Augmentin ayenera kupatsidwa mlingo wotsika. Ndipo kwa ana aang'ono, kuyimitsidwa kwa mankhwalawa ndikoyenera kwambiri.Tiyenera kukumbukira kuti achikulire amathanso kuyimitsidwa, koma kuchuluka kwa 400 mg pa 5 ml ndi koyenera kwa iwo, chifukwa ndi okhawo omwe ali ndi amoxicillin ndi clavulanic acid. Nthawi yomweyo, ana osakwana zaka 2 amatha kupatsidwa kuyimitsidwa ndi Mlingo wa 125 mg. Ana opitirira zaka 2 akhoza kupatsidwa kuyimitsidwa kwamtundu uliwonse. Mlingo wa kuyimitsidwa kwa machitidwe a ana ayenera kuwerengera potengera kulemera kwa thupi la mwana komanso msinkhu wake.

Ana mpaka miyezi itatu. ndikofunikira kupereka mlingo wa tsiku lililonse pamlingo wa 30 mg wa amoxicillin pa kilogalamu ya kulemera. Ana okalamba kuposa miyezi itatu (mpaka zaka 12) - pamlingo wa 20-40 ml pa kg iliyonse ya kulemera (kuyimitsidwa ndi Mlingo wa 125 mg wa amoxicillin) ndi 25-45 ml pa kg yolemera (kuyimitsidwa kwa 200 ndi 400 mg). Kusavuta matendawa, kumachepetsa. Ndikothekanso kudziwa ngati matenda ali akulu kapena ayi, kutengera kutentha kwa thupi. Ngati ndiwotsika kuposa + 38,5 ºС, ndiye kuti matendawa amawonedwa ngati ofatsa, ngati apamwamba, ndiye kuti ndi oopsa.

Kwa matillillitis osachiritsika, matenda, khungu ndi minofu yofewa, ndikwabwino kumwa mankhwala a amoxicillin pafupi ndi malire, chifukwa cha matenda ena opatsirana, Mlingo uli pafupi kwambiri ndi malire.

Mlingo wa tsiku ndi tsiku wa kuyimitsidwa kwa Augmentin uyenera kugawidwa m'magawo angapo tsiku lonse. Ana osaposa zaka 12 amatenga kuyimitsidwa kwa 125 mg katatu patsiku, mitundu yotsalayo ya kuyimitsidwa - kawiri pa tsiku.

Akuluakulu amatha kutenga 20 ml ya kuyimitsidwa kwa 125 mg katatu patsiku, kapena 11 ml ya kuyimitsidwa kwa 400 mg 2 kawiri pa tsiku. Piritsi limodzi la Augmentin 875 mg ndilofanana ndi 11 ml ya kuyimitsidwa kwa 400 mg. Palibe zosankha zina zomwe zitha kusintha. Kuyimitsidwa kwa Augmentin EU ndi mapiritsi a Augmentin SR zitha kutengedwa kokha ndi akulu ndi ana omwe ali ndi thupi lolemera kupitilira 40 kg komanso woposa zaka 12. Kuti mutenge kuyimitsidwa, muyenera kugwiritsa ntchito chipewa choyezera chomwe chimaperekedwa ndi mankhwalawo. Amaloledwa kuchepetsedwa kwa kuyimitsidwa ndi madzi oyera m'chiwerengero cha 1: 1.

Malangizo Okonzekera Kuyimitsidwa

Kwa makolo ena, zingakhale zovuta kwa nthawi yoyamba kuti akonze kuyimitsidwa kuchokera ku ufa womwe ulipo, kulingalira moyenera mlingo woyenera. M'malo mwake, izi sizovuta. Choyamba, ndikofunikira kukumbukira kuti pakukonzekera kuyimitsidwa, ufa wonse kuchokera botolo uyenera kugwiritsidwa ntchito nthawi yomweyo, ndikusiyira pambuyo pake osavomerezeka.

Kukonzekera kuyimitsidwa, onjezani 60 ml ya madzi owiritsa pamoto kutentha kwa botolo la ufa, ndiye kutseka botolo ndi chivundikiro ndikuchigwedeza mwamphamvu mpaka ufa utatha. Kenako muyenera kuyikapo vial kwa mphindi 5. Ngati palibe chinyengo chomwe chimatsalira pansi, ndiye kuti thiraniko madzi pachikatacho. Kuyimitsa komwe kumalizidwa kumatha kusungidwa mufiriji, koma osapitilira sabata.

Malangizo okonzekera njira yothandizira makolo

Ndikofunikira kuchepetsa zomwe zili mu ufa wa vial m'madzi. Kuchuluka kwa madzi ofunikira pa ntchitoyi kumatengera mlingo. Ngati mulingo ndi 500/100, ndiye kuti 10 ml ya madzi iyenera kumwa, ngati 1000/20, ndiye 20 ml. Hafu ya bukuli amawonjezeredwa m'botolo la ufa, kenako limagwedezeka mpaka ufa utasungunuka. Kenako botolo limatha mphindi 5. Ngati palibe matope pansi, ndiye kuti madzi otsalawo amawonjezeredwa m'botolo. Njira yothetsera vutoli imakonzedwa kuti ndi yoyenera kugwiritsidwa ntchito pokhapokha popanda matope omwe atsala pansi pa vial. Njira yothetsera vutoli iyenera kukonzedwa musanayambe kugwiritsidwa ntchito, yankho lotsirizidwa lingathe kusungidwa osaposa mphindi 20.

Mukapaka mankhwala, yankho lomalizidwa limawonjezeredwa ndi madzi a kulowetsedwa (mwachitsanzo, saline), omwe amagwiritsidwa ntchito ngati dontho. Kuti mupeze njira yothetsera mabakiteriya 500/100, 50 ml ya saline ndiyofunikira, kuti mupeze njira yothana ndi mankhwala a 1000/100, 100 ml ya saline. Njira yothetsera kulowetsedwa ikhoza kusungidwa kwa maola 3-4.

Nthawi ya jekeseni wa jet ya kuchuluka kwa njira yothetsera vutoli ndi mphindi 3-4, nthawi ya kulowetsedwa ndi mphindi 30 mpaka 40.

Mayendedwe ena

Kwa anthu omwe ali ndi vuto la impso, mlingo uyenera kusinthidwa kutsikira. Ndi creatinine chilolezo choposa 30 ml / min, kusintha kwa mankhwala sikofunikira. Ndi chilolezo cha 10-30 ml / mphindi, 1 mlingo wa 1000 mg / 200 mg umayamba kupatsidwa, ndiye 500 mg / 100 mg 2 nthawi / tsiku.Ndi chilolezo chochepera 10 ml / mphindi - poyamba 1 mlingo wa 1000 mg / 200 mg ndi mankhwala, ndiye - 500 mg / 100 mg maola 24 aliwonse. Odwala okalamba safunika kuchepetsa mlingo.

Nthawi yayitali ya Augmentin mankhwala, tikulimbikitsidwa kuti nthawi ndi nthawi ntchito ya chiwindi, impso ndi magazi ipangidwe.

Kutalika kwa mankhwala opha maantibayotiki amatsimikiza mwakuya kwa matendawa. Nthawi zambiri, dokotala amakupangira chithandizo chamankhwala masiku 7. Njira ya antibacterial mankhwala osakwana masiku 5 sizimveka. Kumbali ina, sikulimbikitsanso kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, kuposa masiku 14. Pambuyo pa nthawi imeneyi, adokotala amayenera kuwunika zamankhwala. Ngati zizindikiro za matendawa sizichoka patatha sabata limodzi ndi theka, ndiye kuti ndikofunikira kusintha njira yothandizira mankhwalawo m'malo mwake. Komabe, nthawi zina chithandizo cha Augmentin chimatha masabata 3-4. Njira zophatikizira jakisoni wa mankhwalawo ndikumamwa mu mawonekedwe a piritsi ndizothekanso.

Kodi ndizotheka kugawanitsa mapiritsi a mankhwalawa m'magawo? Izi sizikulimbikitsidwa. Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa mapiritsi amayenera kumeza lonse, osafuna kutafuna komanso kumwa madzi ambiri.

Ndikofunika kumwa Augmentin koyambirira kwa chakudya. Komabe, uku sikuti ndikulimbikitsa kokhazikika, popeza kuti kuyamwa kwa mankhwalawa sikudalira kudya kwambiri. Komabe, kafukufuku wasonyeza kuti mukamamwa mankhwalawo ndi chakudya, mwayi wazotsatira zake ndizochepa.

Mlingo

Ufa woyimitsidwa pakamwa 200 mg / 28,5 mg / 5 ml, 70 ml

5 ml ya kuyimitsidwa kuli

ntchito: amoxicillin (monga amoxicillin trihydrate) 200 mg,

clavulanic acid (monga potaziyamu clavulanate) 28.50 mg,

zokopa: xanthan chingamu, aspartame, succinic acid, madzi osokoneza bongo a colloidal silicon dioksidi, hypromellose, kukoma kwa lalanje 610271 E, kukoma kwa lalanje kwa 9/27108, kukoma kwa msipu wowuma kwa NN07943, kununkhira kowuma kwa nyerere za 52927 / AR, kunenepa.

The ufa ndi loyera kapena pafupifupi loyera ndi fungo labwino. Kuyimitsidwa kokhazikikaku ndi koyera kapena pafupifupi kuyera, poyimirira, kutulutsa koyera kapena pafupifupi koyera kumapangika pang'ono.

Mitu ya mankhwalawa

Augmentin ndiwotchipa chokhacho chomwe chimapezeka pamsika chomwe chili ndi clavulanic acid ndi amoxicillin pakapangidwe kake. Mwa mankhwala wamba, mayina monga:

Ambiri aiwo ali ndi mtengo wotsika mtengo poyerekeza ndi Augmentin. Komabe, omwe ndi odwala omwe safuna kuchita chiopsezo ndipo akufuna kuthana ndi mankhwala okhala ndi chitsimikiziro chabwino ndi bwino kugwiritsa ntchito Augmentin.

Mankhwala

Farmakokinetics

Amoxicillin ndi clavulanate amasungunuka bwino pamankhwala amadzimadzi ndi pH yachilengedwe, mwachangu komanso yokwanira kuchokera m'matumbo am'mimba atatha kukonzekera pakamwa. Mafuta a amoxicillin ndi clavulanic acid ndi bwino akamwa mankhwalawa koyambirira kwa chakudya. Mutatha kumwa mankhwalawo mkati, kuphatikiza kwake ndi 70%. Mbiri ya zigawo zonse ziwiri za mankhwalawa ndi ofanana ndipo imafika pachimake cha plasma (Tmax) pafupifupi ola limodzi. Magetsi a amoxicillin ndi clavulanic acid mu seramu yamagazi ndi ofanana onse pakakhala ntchito ya amoxicillin ndi clavulanic acid, ndipo gawo lililonse limasiyanitsidwa.

Zochizira zozama amo amoillillin ndi clavulanic acid zimatheka zosiyanasiyana ziwalo ndi minofu, interstitial madzimadzi (mapapu, m'mimba, chikhodzodzo ndulu, adipose, mafupa ndi minofu minofu, pleural, synovial ndi peritoneal zamadzimadzi, khungu, bile, purulent zotupa, sputum). Amoxicillin ndi clavulanic acid mothandizidwa samalowa mu madzi a cerebrospinal.

Kumangiriza kwa amoxicillin ndi clavulanic acid kuma protein a plasma ndizochepa: 25% ya clavulanic acid ndi 18% ya amoxicillin. Amoxicillin, monga ma penicillin ambiri, amathandizidwa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere.Kupatula kupezeka kwa chiwopsezo cha kukhudzidwa, amoxicillin ndi clavulanic acid sizimawononga thanzi la ana akhanda omwe akuyamwa. Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso ndi owonjezera. Pambuyo pakamwa limodzi lokha piritsi limodzi la 250 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo m'maola 6 oyamba.

Amoxicillin amapukusidwa pang'ono mu mkodzo wofanana ndi penicillinic acid wofanana ndi 10-25% ya mankhwalawa. Clavulanic acid m'thupi imapangidwa mochuluka kuti 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-amodzi ndipo amachotsedwa. ndi mkodzo ndi ndowe, komanso mawonekedwe a mpweya woipa kudzera mumlengalenga.

Mankhwala

Augmentin® ndi mankhwala ophatikiza okhala ndi amoxicillin ndi clavulanic acid, omwe ali ndi zochita zambiri za bactericidal, osagwirizana ndi beta-lactamase.

Amoxicillin ndi mankhwala osokoneza bongo omwe amapanga motsutsana ndi michere yambiri yama gramu ndi gram-negative. Amoxicillin amawonongedwa ndi beta-lactamase ndipo samakhudza tizilombo tating'onoting'ono timene timatulutsa enzyme iyi. Limagwirira a amoxicillin ndikulephera biosynthesis wa peptidoglycans wa bakiteriya cell khoma, zomwe nthawi zambiri zimayambitsa lysis ndi cell kufa.

Clavulanic acid ndi beta-lactamate, yofanananso ndi mankhwala opangidwa ndi penicillin, omwe amatha kuphatikiza ma enzymes a beta-lactamase omwe amaletsa penicillin ndi cephalosporins, potero amateteza kutha kwa amoxicillin. Ma Beta-lactamases amapangidwa ndi mabakiteriya ambiri opanda gramu komanso gram-negative. Kuchita kwa beta-lactamases kumatha kubweretsa kuwonongeka kwa mankhwala ena a antibacterial ngakhale asanayambe kukhudza tizilombo toyambitsa matenda. Clavulanic acid imalepheretsa ma enzymes, kubwezeretsa chidwi cha mabakiteriya ku amoxicillin. Makamaka, imakhala ndi ntchito yayikulu yolimbana ndi plasmid beta-lactamases, yomwe mankhwala osokoneza bongo amakhudzidwa nthawi zambiri, koma osagwira motsutsana ndi mtundu wa 1 chromosomal beta-lactamases.

Kupezeka kwa clavulanic acid ku Augmentin® kumateteza amoxicillin ku zowonongeka za beta-lactamases ndikukulitsa mawonekedwe ake a zochita za antibacterial ndikuphatikizidwa kwa ma cellorganices omwe nthawi zambiri amakhala osagwirizana ndi penicillin ena ndi cephalosporins. Clavulanic acid okhala ngati mankhwala amodzi alibe mphamvu zambiri za antibacterial.

Njira yokana kukana

Pali njira ziwiri zoyambitsira kukana kwa Augmentin ®

- inactivation ndi bakiteriya-mabakiteriya, omwe samazindikira zotsatira za clavulanic acid, kuphatikizapo magulu B, C, D

- Kusintha kwa mapuloteni omanga a penicillin, omwe amachititsa kuchepa kwa mgwirizano wa antioxotic pokhudzana ndi microorganism

Kukhazikika kwa khoma la mabakiteriya, komanso njira zopopera, zimatha kuyambitsa kapena kuthandizira kukulitsa kukana, makamaka pamagalamu opanda tizilombo.

Augmentin®ali ndi bactericidal pa zotsatirazi tizilombo:

Zoyipa zamagalamu: Enterococcus faecalis,Gardnerella vaginalis,Staphylococcus aureus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin), Streptococcus agalactiae,Streptococcus pneumoniae1,Streptococcus pyogene ndi ena beta hemolytic streptococci, gulu Streptococcus viridans,Bacillius anthracis, Listeria monocytogene, Nocardia asteroides

Ma grram-negative: Chizimbamangochita,Kapnocytophagaspp.,Eikenellacorrodens,Haemophilusfuluwenza,Mwanaxellachibimanga,Neisseriamichere,Pasteurellamultocida

tizilombo toyambitsa matenda: Bacteroides fragilis,Fusobacterium nucleatum,Prevotella spp.

Ma tizilombo tating'onoting'ono tomwe titha kupezeka nawo

Zoyipa zamagalamu: Enterococcusfaecium*

Ma tizilombo okhala ndi chilengedwe:

ma gram-negative aerobes: Acinetobactermitundu,Choprobacterfreundii,Enterobactermitundu,Legionella pneumophila, Morganella morganii, Providenciamitundu, Pseudomonasmitundu, Serratiamitundu, Stenotrophomonas maltophilia,

china: Chlamydia trachomatis,Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

*Zomverera mwachilengedwe pakakhala zopanda kukana

1 zopatula Streptococcus pneumoniaepenicillin

Mlingo ndi makonzedwe

Kuyimitsidwa kwamakonzedwe a pakamwa kumapangidwira kuti azigwiritsa ntchito ana.

Kuzindikira kwa Augmentin ® kumatha kusiyanasiyana ndi malo ndi nthawi. Musanafotokozere mankhwala, ngati kuli kotheka ndikofunikira kuwunika momwe matulukidwewo alili molingana ndi deta yakumaloko ndikuzindikira zamverazo ndikusanthula zitsanzo kuchokera kwa wodwala wina, makamaka ngati akudwala kwambiri.

Mlingo wa mankhwalawa umakhazikitsidwa payokha kutengera zaka, kulemera kwa thupi, impso, matenda othandizira, komanso kuopsa kwa matendawa.

Augmentin® ndikulimbikitsidwa kuti idatenge kumayambiriro kwa chakudya. Kutalika kwa mankhwalawa kumatengera wodwala momwe amathandizira. Ma pathologies ena (makamaka, osteomyelitis) angafunike nthawi yayitali. Kuchiza sikuyenera kupitilizidwa kwa masiku opitilira 14 popanda kuonanso momwe wodwalayo alili. Ngati ndi kotheka, ntha kuchita njira ya mankhwala (yoyamba, intravenous makonzedwe a mankhwala ndikusinthira kwamkamwa makonzedwe).

Ana kuyambira miyezi iwiri mpaka zaka 12 kapena masekeli osakwana 40

Mlingo, kutengera zaka ndi kulemera kwake, umawonetsedwa mu mg / kg pa thupi patsiku kapena mamililita a kuyimitsidwa kumene.

Mlingo woyenera:

- kuyambira 25 mg / 3.6 mg / kg / tsiku mpaka 45 mg / 6.4 mg / kg / tsiku, logawidwa mu 2 Mlingo, chifukwa cha matenda ofatsa komanso olimbitsa thupi (obwereza matani, khungu ndi minofu yofewa)

- kuchokera pa 45 mg / 6.4 mg / kg / tsiku mpaka 70 mg / 10 mg / kg / tsiku, logawidwa mu 2 Mlingo, pochizira matenda oopsa (otitis media, sinusitis, matenda am'munsi opatsirana thirakiti).

Tchati Chosankha Cha Augmentin Chimodzi® kutengera kulemera kwa thupi.