Metformin 1000 mg: mtengo, ndemanga ndi malangizo

Mapiritsi, 500 mg, 850 mg ndi 1000 mg

Piritsi limodzi la 500 mg lili:

ntchito yogwira: metformin hydrochloride - 500 mg.

muobwera: microcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Piritsi limodzi la 850 mg lili:

ntchito yogwira: metformin hydrochloride - 850 mg.

muothandizira zinthu: cellcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Piritsi limodzi la 1000 mg lili:

yogwira chinthu: metformin hydrochloride - 1000 mg.

auxmachiritso zinthu: cellcrystalline cellulose, croscarmellose sodium, madzi oyeretsedwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Mapiritsi 500 mg - mapiritsi ozungulira ozungulira amiyala yoyera kapena pafupifupi oyera okhala ndi chiopsezo mbali imodzi ndi chamfer kumbali zonse ziwiri.

Mapiritsi 850 mg, 1000 mg - mapiritsi a oic biconvex amtundu woyera kapena pafupifupi woyera wokhala ndi chiopsezo mbali imodzi.

Mankhwala

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera kumimba kwathunthu. Mtheradi bioavailability ndi 50-60%. The ndende yambiri (Cmax) (pafupifupi 2 μg / ml kapena 15 μmol) mu plasma imatheka pambuyo maola 2,5.

Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa.

Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma. Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuvomerezeka kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa kutulutsa chilolezo cha creatinine), zomwe zikuwonetsa kukhalapo kwa secalic secretion. Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kupezeka kwa mankhwalawa.

Metformin imachepetsa hyperglycemia popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Amalepheretsa gluconeogenesis m'chiwindi. Imachedwetsa mayamwidwe am'mimba m'matumbo. Metformin imathandizira kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yonse, lipoproteins yotsika komanso triglycerides.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Zizindikiro zogwiritsidwa ntchito

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:

• Akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa, kapena ndi insulin,

• mwa ana kuyambira zaka 10 monga monotherapy kapena kuphatikiza insulin.

Mlingo ndi makonzedwe

Mapiritsi amayenera kumwedwa pakamwa, kumeza lonse, osafuna kutafuna, pakudya kapena mukangomaliza kudya, kumwa madzi ambiri.

Akuluakulu: monotherapy ndi kuphatikiza mankhwalawa kuphatikiza ena othandizira pakamwa:

• Mlingo woyambira wamba ndi 500 mg kapena 850 mg katatu patsiku mutatha kudya kapena pakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

• Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba ndi 3000 mg / tsiku, logawidwa pazidutswa zitatu.

• Kuchepetsa kwa pang'onopang'ono kumathandizanso kulolerana kwam'mimba.

• Odwala omwe akutenga metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsira ku 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Pankhani yakukonzekera kusinthaku kuti mutenge wina wothandizila wa hypoglycemic: muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Metformin muyezo womwe tafotokozazi.

Kuphatikiza ndi insulin:

Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Metformin 500 mg kapena 850 mg piritsi limodzi katatu patsiku, Metformin 1000 mg ndi piritsi limodzi nthawi imodzi patsiku, pamene insulini imasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ana ndi achinyamata: mwa ana azaka 10, mankhwala Metformin angagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi patsiku mutatha kudya kapena. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba: chifukwa cha kuchepa kwa aimpso, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa kuchuluka kwa creatinine mu seramu osachepera 2-4 pachaka).

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Kuchotsera kwa mankhwalawa popanda upangiri wa dokotala simukulimbikitsidwa.

Mitengo ya metformin m'mafakisi ku Moscow

Madokotala amawunika za metformin

Mankhwala "Metformin" atchuka kwambiri, amakhala ndi niche yake pakati pa mankhwala ochepetsa thupi. Kukhazikitsidwa bwino kwambiri pakati pa gynecologists-endocrinologists. Chachikulu ndikusankha njira yolandirira yoyenera. Imathandiza kwambiri pochiza matenda ashuga.

Mawonekedwe a piritsi la ena opanga ndi akulu kwambiri ndipo ndi osavuta kumeza.

Lumikizanani ndi endocrinologist musanagwiritse ntchito.

"Metformin" imawonetsa mawonekedwe atsopano ndikuwonjezera mphamvu pamalopo. Ndimagwiritsa ntchito urology ndi bwino, kugwiritsa ntchito Metformin kumayendetsedwa ndi kuchepa kwa mawonekedwe a mafuta a viscero-m'mimba. Ali ndi zovuta zina za hemodynamic. Zotsatira za anticarcinogenic za Metformin ndizosangalatsa, makamaka pokhudzana ndi khansa ya Prostate.

Nthawi zambiri ndimazigwiritsa ntchito pofuna kupewa.

Ndimakonda mankhwala omwe amachepetsa thupi, ngati atchulidwa mwanzeru, makamaka zowona m'mitsempha ya varicose yomwe ili ndi nkhondo yolimbana ndi kunenepa kwambiri.

Chithandizo chopanda nzeru cha madokotala ambiri, makamaka akatswiri azachipatala.

Ndinayesa kutenga ndekha - kuchokera ku zoyipa zomwe zinali ndi zovuta zam'mimba, chizungulire pang'ono, zosachedwa kusuntha tsiku limodzi.

Mankhwala othandiza kwambiri komanso oyenera pokhudzana ndi mankhwalawa a endocrinological pathology (shuga mellitus, matenda a metabolism).

Kuchepa kwa zovuta zoyipa, kutsekula m'mimba ndizambiri, ndipo kutsutsana kumathandizanso.

Itha kugwiritsidwa ntchito ngati mono-therapy, kapena molumikizana ndi mankhwala ena.

Kugwiritsa. Kutengera zodzitetezera - chitetezo.

Nthawi zambiri odwala amakhala ndi vuto la dyspeptic ndi kutsekula m'mimba. Kulemera kumachepetsedwa pamlingo wina, kenako popanda mphamvu.

Chida chapamwamba kwambiri chochizira matenda amishuga 2 omwe amachitika mothandizidwa ndi mankhwalawa. Zotsatira zabwino zama kagayidwe kachakudya ndikugwiritsa ntchito nthawi yayitali kumathandizira kuchepetsa thupi.

Mankhwala adatsimikizira mu endocrinology yochizira matenda a shuga komanso kuwonda, chifukwa - amachepetsa kuthamanga kwa magazi.

Zotsatira zoyipa - kusokonezeka kwa m'mimba thirakiti (kuchepa kwa chakudya, kutsegula m'mimba).

Amawonetsedwa kwa odwala omwe ali ndi insulin kukana.

Pazaka zambiri zogwiritsidwa ntchito, mankhwalawa "Metformin" atsimikizira kuti ndi chida chothandiza kwambiri polimbana ndi kunenepa kwambiri, mankhwalawa amathandizanso kwambiri matenda a shuga a 2, makamaka poyambira. Mankhwala omwe ali ndi zotsimikizira matenda munthawi yochepa amakulolani kukwaniritsa izi.

Kuyanjana bwino ndi mankhwala ena. Mankhwala othandiza kwambiri.

Kuleza mtima ndikusawuka, kuwuma kwa zovuta kumachepetsa kutsatira.

Pamaso pa insulin kukaniza, njira yabwino yothanirana ndi kuchepetsa kunenepa. Zotsatira zoyipa (nseru, kuchepa kwamphamvu kwa chikhumbo) nthawi zina zimadzetsa kudzipangitsa okha kwa odwala.

Kwazaka zambiri, ndakhala ndikulembera metformin mwachangu za matenda a carbohydrate metabolism (kulekerera kwamphamvu kwa ma carbohydrate, mtundu wa 2 matenda osokoneza bongo), makamaka onenepa kwambiri, wokhala ndi sclerocystosis yam'mimba m'mimba mwa insulin. M'mayiko ena, amaloledwa kugwiritsidwa ntchito panthawi yomwe ali ndi pakati.

Zotsatira zoyipa - pafupipafupi kutsekula m'mimba (kumayambiriro kwa chithandizo).

Mankhwala ochokera pagulu la Biguanide anali oletsedwa nthawi imodzi mpaka kumapeto kwa zaka za 90s, koma anali ndi nthawi imeneyo malingaliro, amatha kupezeka mumafesi, operekedwera bwino chifukwa cha kusala kudya kwa hyperglycemia. Kenako metformin idawonekera ndipo ndi mwayi weniweni kuthandiza odwala matenda ashuga.

"Metformin" - mankhwalawa amasankha matenda amitundu iwiri musanayambike matendawa, omwe amakhala ndi hemoglobin yotsika, amathetsa mavuto a kagayidwe kazakudya, kunenepa kwambiri, komanso kunenepa kwambiri. Mankhwala kumawonjezera kudziwa kwa zimakhala ndi insulin, potero kusintha chikhalidwe cha thupi matenda limodzi ndi insulin kukana.

Ichi ndi mankhwala atsopano ndipo pakadali pano ndi othandiza kwambiri pazofanizira zomwe zilipo. Imagwiritsidwa ntchito kamodzi madzulo, kwathunthu kwathunthu mankhwala onse. Pogwiritsa ntchito mankhwalawa ndi odwala, palibe mavuto omwe adadziwika.

Muzochita zanga ndimagwiritsa ntchito mankhwala amakono Metformin pochiza matenda ashuga.

Mankhwala amathandizira kudziwa kukoka kwa ma receptors kuti apange insulin ndi insulin. Vutoli limayendera limodzi ndi azimayi ambiri a premenopausal komanso azimayi okana, okhala ndi polycystic ovary syndrome. Ndimayeserera kuyeserera nditatsimikizira kuti ndazindikira kuti ndili ndi matenda a labotale. Mankhwala amatithandizanso kudziwa mawonekedwe a lipid.

Matenda a kagayidwe kazachilengedwe, zimadalira njira zosiyanasiyana. Chimodzi mwazofunikira ndikuwongolera kuchepa kwa micronutrient, komanso mafuta achilengedwe a polyunsaturated.

Zotsatira zake zoyipa zimaphatikizapo chimbudzi komanso kumasuka. Mankhwalawa amatengedwa madzulo, kuti muchepetse kuwonongeka kwa zovuta, tikulimbikitsidwa kuti musamamwe mankhwala azopatsa mafuta madzulo (makamaka ngati mankhwalawa adalembedwa kuti achepetse kulemera, motsutsana ndi maziko a insulin kukana.

Mankhwalawa amagwiritsidwa ntchito ndi endocrinologists kuchiza matenda a insulin, kunenepa kwambiri (motsutsana ndi maziko a insulin kukana), komanso matenda a shuga. Mankhwala amayenera kuperekedwa ndi dokotala malinga ndi zomwe akuwonetsa. Pofuna kuchepetsa thupi pakakhala insulin kukana (kupezeka kwake, kachiwiri, kutsimikiziridwa ndi adokotala), mankhwalawa sagwira ntchito. Chifukwa chake, musadziderere, pezani thandizo kuchokera kwa akatswiri oyenerera.

Mankhwala okhala ndi kutsimikizika kwachipatala, ndimagwiritsa ntchito mankhwalawa kunenepa kwambiri, ntchito ya mankhwala yoletsa kukalamba, mankhwalawa a mtundu 2 wa matenda a shuga awonekera.

Nthawi zina pamakhala mseru mutatenga, mutha kutumiza mankhwalawo.

Mankhwala abwino okhala ndi kanthu kotsimikizika ka ndalama zochepa.

Ndemanga za odwala

Mankhwala olandirika bwino pamtengo komanso m'njira yoti sangakwanitse kuchita mankhwala azachipatala ku Moscow! Ndakhala ndikumwa mankhwalawa kwa miyezi isanu ndi umodzi tsopano, monga matenda a shuga a 2 adapezeka, ndipo amathandizadi. Zowongolera zenizeni zikuwoneka. Shuga watsika pafupifupi mpaka pakufunika. Nditamwa mankhwalawo ndikuchepetsa shuga, thanzi langa lidayamba kuyenda bwino. Ndikofunika kudziwa kuti osatenga zotsatirapo zoyipa adazindikiridwa ndipo iyi ndi njira inanso yophatikizira mankhwalawa! Zidapezeka kuti mankhwalawa, kwa ine ndekha, ali ndi kuphatikiza kumodzi. Mtengo, kupezeka, zotsatira ndi kusowa kwa zoyipa. Koma, musaiwale kuti mankhwala aliwonse ayenera kumwedwa mosamalitsa monga adanenera.

Chifukwa chake tidapeza piritsi lomwelo lamatsenga. Mankhwala othandiza kwambiri omwe amathandiza kuchepetsa thupi. Mankhwalawa adawonetsedwa pa njira yoyamba ya pulogalamu ya Livena Malysheva's Live Healthy, pomwe adalankhula mwatsatanetsatane za mankhwalawa. Kenako ndidalakalaka kuti ndikamve, zomwe zachitika. Ngati muwerenga malangizowo, mutha kuwona kuti mankhwalawa amapangidwira okhawo omwe ali ndi matenda ashuga kuti achepetse shuga. Mutha kuganiza za matenda ashuga komanso kuwonda. Zonsezi zimaphatikizapo insulini, munthu akayamba kunenepa kwambiri, amapezeka ndi insulin yochulukirapo, mankhwalawo, amapanga kuchuluka kwa insulin m'magazi, ndipo munthuyo samakhala wonenepa. Pomaliza, ndinachotsa mapaundi owonjezera.

Pambuyo pa zaka 30, ndidayamba kulimbitsa thupi. Ngakhale ndimatsatira malamulo azakudya zoyenera, nthawi zina ndimatha kugula chinthu chokoma. Ndidapasa mayesowo ndipo pamapeto pake ndidapezeka kuti ndili ndi matenda ashuga a 2. Ndinali ndi nkhawa, koma chisangalalo changa, ndidatembenukira kwa katswiri wazomwe adalemba mankhwala omwe amafunikira chithandizo, kuphatikizapo Metformin. Metformin sanangondithandiza ndi mafuta ochulukirapo, zimathandizanso kuchepetsa shuga. Komanso ndi izi, kulakalaka kwanga kunachepa ndipo zakudya zanga zimachepa. Sindinazindikire mavuto aliwonse, chifukwa ndimatsatira malangizo omveka bwino ogwiritsira ntchito mankhwalawa.

Chifukwa cha matenda ashuga amtundu wa 2, ndinayamba kuchuluka kwambiri, pafupifupi 17 kg. Ndinayesera kuchepetsa thupi pazakudya, koma zinkandivuta kuti ndidziletse, chifukwa monga momwe adanenera adotolo, ndidayambanso kumwa Metformin. Koma sizinathandize chifukwa cha zotsatira zoyipa. Ndinasintha "Glucophage" 1000 mg. Mankhwalawa amachepetsa shuga, komanso amathandizira kuchepetsa thupi. Kale m'miyezi itatu yoyambirira adataya 10 kg. Adapitilizabe kumwa Glucofage ndipo adatayanso kilogalamu 7 m'miyezi iwiri. Chifukwa cha miyezi isanu ndi umodzi ndinadzikonzekeretsa ndekha, ndipo shuga ndinakhala wabwinobwino. Tsopano ndikumva bwino, chifukwa cha Glucofage!

Agogo anga aakazi ali ndi matenda ashuga. Adayesera mankhwala ambiri, adachita zochepa kuthandiza, kapena kuthandiza, kenako mobwerezabwereza. Nditawona kwina kutsatsa kwa Metformin, tinaganiza zofunsa dokotala. Ndipo pamapeto pake, shuga adayamba kutsika, agogo anga aamuna adayamba kumva bwino, komanso adayamba kunenepa.

Anali ndi vuto lolemera kwambiri kwa nthawi yayitali (pafupifupi makilogalamu 25 kuchoka pachikhalidwe). Sindimatha kuchepetsa thupi kwanthawi yayitali, ndinayesa zida ndi maluso osiyanasiyana.Ndinaganiza zopita kuchipatala cha mumzinda, komwe ndinakaphunzitsidwa ndi adotolo za kukonzekera kwa Metformin. Mankhwalawa adandithandizira kuchepetsa thupi ndi 10 kg m'miyezi 3.5 ndipo ndikupitilirabe kumwa mopitilira osasintha mlingo. Mtengo suuma ndipo umagulitsidwa m'mafakisi ambiri mumzinda wanga. Ndimalangiza aliyense amene ali ndi vuto lotere.

Kwa milungu ingapo, kudya zakudya zosiyanasiyana mwachangu, ndidachira. Changu changa chofuna kuchepetsa thupi chawonjezeka kwambiri, ndidalangizidwa mankhwala "Metformin". Zachidziwikire, ine, monga wina aliyense, sindinakhulupirire pakugwiritsa ntchito chida ichi. Koma, m'malo mwake, amatha kundidabwitsa, chifukwa Metformin amapha kotheratu kumverera kwanjala. Ndinkatenga katatu patsiku ndipo ndimanenepa kwambiri. Chodabwitsa, panalibe mavuto panthawi yogwiritsa ntchito pachabe. Ndinadabwitsidwanso ndi mtengo wake, chifukwa ndizotsika mtengo kwambiri kuposa malonda ofanana. "Metformin" inathandiza kwambiri kuthetsa vuto langa, chifukwa ndinayamba kukonzanso kale sabata yoyamba.

Mankhwalawa ndi abwino kwambiri, ndidawerenga za iwo ndemanga zingapo, zabwino ndi zoyipa, koma ndidasankha kuti ndiyesere kuzigwiritsa ntchito ndekha ndikukhulupirira kutha kwake. Ndidakondwera ndi zomwe zimachitika. Nditatha kumwa mankhwalawo, ndidatha kuzindikira kusintha kwakusintha. Kulemera kwanga kunayamba kuchepa pang'onopang'ono, sindinganene kuti ndinataya 20 kg, koma khola 4 pamwezi linali litapita, ichi ndichizindikiro chabwino kwa ine. Mtengo wa mankhwalawa uli mgulu la kupezeka, chilichonse chimakwanira.

Amayi anga ali ndi matenda ashuga a 2. Adatenga Metformin kwa zaka 7, kuyambira 2008 mpaka 2015. Adazipeza zaulere, monga adanenera dokotala. Kenako adapita kuchipatala chawekha, kukayang'aniridwa kawiri. Atatha kuyesa, adotolo mu mawonekedwe okhwima amaletsa kumwa mankhwalawa! Mwambiri, Metformin anasiya 40% ya impso kwa amayi! Chifukwa chake, lingalirani za momwe mumalipira kuti muchepetse kunenepa komanso kutsika shuga.

Ndamva za Metformin kuchokera kwa abwenzi a amayi anga chaka chapitacho. Malinga ndi nkhani zake, ngati mumamwa Metformin musanadye kawiri patsiku, osamadya maswiti ndipo nthawi zambiri amachepetsa zakudya zamafuta, ndiye kuti kulemera kwake kumachoka mwachangu. Sindimadya maswiti konse, koma ndikapitiliza kudya, ndiye kuti chozizwitsa sichinachitike. Ndinawerenga za izi pa intaneti ndikuganiza zopeza mwayi, chifukwa patatha mwezi umodzi, akupita kunyanja. Mapeto ake, ndinamwa mapiritsiwa kwa masiku atatu. Ndipo zinanditengera 3 kg. Ndinali wokondwa kwambiri ndi izi. Adayambanso kulangiza abwenzi ake. Zowona zake, zovuta zake sizabwino kwambiri, m'mimba mwake mudawapweteka kwambiri atatha kudya. Ndiye chifukwa chake sindinapitilize kumwa iwo. Ndinali wokondwa kwambiri ndi zotsatirapo zake. M'nyengo yozizira ine ndimamwa tchuthi cha Chaka Chatsopano chisanachitike, nawonso ma kilos angapo adatsala m'masiku angapo. Tsopano ndinayambanso kumwa iwo. Ndikonzekereratu tchuthi. Zotsatira zake sizinayesedwebe. Mwambiri, ngati mumamwa kwakanthawi kochepa, mowerengeka komanso molumikizana ndi zakudya, ndiye kuti zotsatira zake sizikutenga nthawi yayitali!

Ndili ndi matenda ashuga a 2, ndakhala ndikumwa Medformin pafupifupi chaka chimodzi, kulemera kwanga sikunachepe, mwatsoka. Pambuyo pa kulandiridwa kwamadzulo kwa Medformin, zhor idayamba. Tsopano ndimamwa piritsi yachiwiri ndisanayambe kugona, zonse zakhala zabwinobwino. M'mawa, shuga kuyambira 6 mpaka 7.2 amagwira. Amasankhanso mankhwala "Jardins" 25mg., Wokondedwa: 2.900 pamwezi.

Moni Mankhwalawa amandithandizanso kunenepa kwambiri. Mwazi wamagazi unakulitsidwa kwambiri ndipo Metformin idakwanitsa kuisintha. Kulemerako kumachoka pang'onopang'ono, kumatenga miyezi isanu ndi umodzi monga adalamulira adokotala. Ndizabwino kuti mtengo wake ndiwothandiza komanso mankhwalawo amathandiza!

Ndinapeza chida ichi, ndikuyembekeza kuti ndi chithandizo chake nditha kuchepa thupi pang'ono. Wophatikiza zakudya adalengeza zotsimikiza za mankhwalawa. Mwachilengedwe, sindinataye 1 kg. Tsiku lililonse ndimapita kukachita masewera kwa ola limodzi, ndimangodya masamba ndi zipatso zokha, ndikugwiritsa ntchito mapiritsiwa, kwa mwezi umodzi sindinataye ngakhale 0,5 kg. Sindikudziwa kuti ndinganene chiyani. Mwina, popereka mankhwala kwa ine, wathanziyu sanatchule chilichonse. Mwina zinathandiza wina, koma osati ine. Zambiri, chifukwa chake, kuwononga ndalama ndi ziyembekezo zopanda pake.

Ndili ndi matenda ashuga a 2. Ndakhala ndikutenga Metformin kuphatikiza jakisoni wa insulin kwa pafupifupi chaka. Mankhwalawa amachepetsa shuga m'magazi, posachedwa ndidasokonezeka kwakukulu ndikupereka insulin. Masabata awiri adayenera kutenga "Metformin" imodzi ndipo adandisangalatsa ndi ntchito yake yabwino. Ndipo ndilinso ndi matenda a chiwindi, pankhaniyi, ndidaphunzira malingaliro a dotolo momwe Metformin amakhudzira chiwindi changa chodwala. Anandisangalatsa, akunena kuti zonse zili m'dongosolo, musataye mtima - zilibe tanthauzo. Mwambiri, ineyo pandekha ndimakondwera ndi mankhwalawa. Koma anthu onse ndiosiyana ndipo thupi la aliyense ndi losiyana kotero yang'anani, lingalirani, funsanani ndi madokotala.

Ndidatenga Metformin monga adanenera a endocrinologist. Cholinga chachikulu chinali kutaya mapaundi owonjezera amenewo. Shuga wanga anali wabwinobwino, ngakhale anali kusinthasintha m'malire apamwamba. Kuphatikiza apo, kuyeserera kwa glucose sikunawonetse vuto lililonse, hemoglobin ya glycated sinapitirire zofunikira. Kuyambira pachiyambireni kumwa Metformin ndi zakudya zama carb ochepa, ndataya kale ma kilogalamu khumi. Nthawi yomweyo, mkhalidwe wa pakhungu pakhungu ulinso bwino, kuchuluka kwa mutu wakuda watsika, khungu silonenepa monga kale. Kuphatikiza apo, shuga adachepa pang'ono.

Ndili ndi matenda ashuga a 2. Adatenga glibenclamide kwakanthawi, ndipo posachedwa adayamba kusintha metformin. Ndikuvomereza kuti mankhwalawa amalekeredwa mosavuta, mtengo wotsika mtengo. Mwazi wamagazi watsika pang'ono, zakhala bwino.

Ndili ndi matenda ashuga, zikomo Mulungu, ayi. Komabe, kuyambira ndili mwana ndimakonda kukhala wonenepa kwambiri. Nditangomenya nkhondo, ndidazungulirazungulira. Mnzanga wapamtima ndi dokotala wanga. Komanso chubby. Nthawi ina adanena kuti tsopano tidzamwa Metformin kuti muchepetse thupi. Palibe chifukwa chokhulupirira, adayamba kumwa piritsi tsiku. Patatha mwezi umodzi, ndinaponyera, sizikugwira ntchito kwa ine, ndinali kudwala ndipo mutu wanga ukupindika. Koma mnzake adapulumuka, ndimamwa kwa miyezi isanu ndi umodzi, ndipo kulemera kwake kunachepa pang'onopang'ono ndi m'malovu. Zotsatira zake, idatsika ndi 9 kg. Matenda a shuga nawonso si odwala. Palibe vuto, sindilangiza aliyense, ngakhale dokotala mwiniyo adagwiritsa ntchito njira iyi, ndimangogawana nawo ntchito yogwiritsira ntchito metformin.

Potsatira kuyeserera kwakuthupi, adawonetsa kuchuluka kwa shuga m'magazi (motsutsana ndi maziko a kupsinjika kwakukulu). Dokotala adazindikira mtundu wachiwiri wa matenda ashuga. Mankhwala - mankhwala a metformin. Ndakhala ndikutenga kwa miyezi isanu ndi umodzi tsopano. Poyerekeza zakudya ndi momwe mankhwalawo amathandizira, shuga adachepa. Mankhwalawa amalekeredwa mosavuta, amapezeka m'masitolo ogulitsa komanso pamtengo. Zowona, metformin imakhala yoletsa pang'ono. Ndipo kumwa mankhwalawo kunandithandiza kuchepetsa kuthamanga kwa magazi ndikuchepetsa "makilogalamu 11 a kunenepa kwambiri. Ndimapitiliza kulandira chithandizo popanda kuwonjezera kuchuluka kwa mankhwalawa.

Metformin inandithandiza kuthana ndi insulin. Anali wamfupi ndipo sanakhudze kulemera kwanga. Koma chifukwa cha iye, panali zovuta ndi thumba losunga mazira. Pogwiritsa ntchito metformin, njira yoberekera ibwerera mwakale, ndinatha kutenga pakati.

Kufotokozera kwapfupi

Matenda a shuga ndi imodzi mwazovuta zazikulu zamankhwala amakono. Amaleredwa pamwambapa chifukwa cha kukwera mtengo kwa chithandizo, zovuta komanso zovuta (mpaka kulumala), komanso kufa kwamphamvu. Chifukwa chake, pakati pa odwala omwe ali ndi matenda amtundu wa 2, kufa kwawo kumakhala kuchulukirapo kawiri konse kuposa kumene kuli ambiri. Metformin ya pakamwa ya hypoglycemic idapangidwa kuti igwire nkhondo chimodzimodzi ndi matendawa, "okoma" modabwitsa, koma osatinso chowonadi chake. Masiku ano, mankhwalawa sangatchulidwe mwanjira ina yopanga nzeru: wayambitsidwa mu machitidwe a endocrinological kuyambira kumapeto kwa zaka za 50s. zaka zana zapitazo. Pakadali pano, metformin ndi, yopanda kukokomeza, mankhwala ochepetsa mphamvu kwambiri piritsi. Kapangidwe ka kachitidwe kake kanakhala kamafotokozedwatu m'mashelufu, ndipo izi zimamupangiranso iye. Metformin imalepheretsa gluconeogeneis (kaphatikizidwe kagayidwe) m'magazi, imachepetsa kuyamwa kwa glucose m'matumbo ang'ono, imawonjezera kuthekera kwa zotumphukira zogwiritsa ntchito shuga, ndikuwonjezera chidwi cha minyewa yolandirira. Chofunika kwambiri, mankhwalawa samakhudza kupanga kwa insulin yake kapamba ndipo samayambitsa zotsatira za hypoglycemic zomwe zimachitika ndi mankhwala ochepetsa shuga (muyeso womwe umatha kukhala hypoglycemic chikomokere).

Zotsatira zina zamankhwala zimaphatikizira kuchepa kwa kuchuluka kwa triglycerides ndi "zoyipa" lipoproteins (LDL) m'magazi, kukhazikika (komanso nthawi zina ngakhale kuchepa) m'kulemera kwake kwa wodwala, komanso kuchitidwa kwa fibrinolytic (antithrombic).

Mlingo wa metformin umatsimikiziridwa ndi dokotala munthawi iliyonse ndipo zimatengera kuchuluka kwa shuga m'magazi. Malinga ndi malingaliro onse, mankhwalawa amayamba kumwa ndi 500-1000 mg (omwe ali ofanana ndi mapiritsi a 1-2). Pambuyo masiku 10-14, amaloledwa kuwonjezera mlingo, kutengera zomwe zikuwonetsa masiku ake kuchuluka kwa magazi. Mlingo wokonzanso wa metformin umachokera ku 1500-2000 mg, omwe ndi 3000 mg. Okalamba okalamba ndi vuto lapadera. Choyamba, dziwani kuti mwa anthu azaka makumi asanu ndi awiri, omwe, ngakhale ali ndi zaka zambiri, akupitiliza kugwira ntchito zolimbitsa thupi, metformin ikhoza kuyambitsa lactic acidosis. Pankhaniyi, kumwa mankhwalawa kwa odwala kumapangidwa. Nthawi zina, okalamba sayenera kumwa zosaposa 1000 mg za metformin patsiku. Mapiritsi amalimbikitsidwa kuti amwe ndi chakudya kapena pambuyo pake ndi kapu yamadzi. Mlingo wa tsiku ndi tsiku nthawi zambiri umagawidwa pawiri.

Pharmacology

Oral hypoglycemic wothandizila kuchokera pagulu la Biguanides (dimethylbiguanide). Kupanga kwa zochita za metformin kumalumikizidwa ndi kuthekera kwake kuponderezera gluconeogeneis, komanso mapangidwe a mafuta achilengedwe omasuka ndi kukhatikiza kwa mafutawa. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Metformin siyimakhudzanso kuchuluka kwa insulin m'magazi, koma imasintha ma pharmacodynamics pochepetsa kuchuluka kwa insulini kuti imasulidwe ndikuwonjezera kuchuluka kwa insulin kuti proinsulin.

Metformin imalimbikitsa kapangidwe ka glycogen pochita glycogen synthetase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose. Kuchepetsa mayamwidwe m'matumbo.

Amachepetsa msana wa triglycerides, LDL, VLDL. Metformin imakweza michere yamagazi ya fibrinolytic mwa kuponderezana ndi minyewa yokhala ngati minofu ya plasminogen activator inhibitor.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imayamba pang'onopang'ono komanso osakwanira kuchokera mmimba. C_max mu plasma imafikiridwa patatha pafupifupi maola 2,5. Ndi gawo limodzi lokha 500 mg, tanthauzo lenileni la bioavailability ndi 50-60%. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa.

Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma. Amadziunjikira mu ndulu zakumaso, chiwindi ndi impso.

Imafufutidwa ndi impso zosasinthika. T_1/2 kuchokera ku plasma ndi maola 2-6.

Pankhani ya kuwonongeka kwaimpso, kuwerengetsa kwa metformin ndikotheka.

Kutulutsa Fomu

Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (5) - mapaketi a makatoni.
Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (10) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (12) - mapaketi a makatoni.
15 ma PC. - mapepala otumphukira (2) - mapaketi a makatoni.
15 ma PC. - mapaketi a matuza (4) - mapaketi a makatoni.
15 ma PC. - matumba otumphukira (8) - mapaketi a makatoni.

Amamwa pakamwa, panthawi ya chakudya kapena itatha.

Mlingo komanso kuchuluka kwa makonzedwe zimatengera mtundu womwe umagwiritsidwa ntchito.

Ndi monotherapy, muyeso umodzi woyamba wa akulu ndi 500 mg, kutengera mtundu womwe umagwiritsidwa ntchito, pafupipafupi makonzedwe ake ndi katatu kapena tsiku. Ndizotheka kugwiritsa ntchito 850 mg 1-2 nthawi / tsiku. Ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono ndi sabata limodzi. mpaka 2-3 g / tsiku.

Ndi monotherapy ya ana azaka zapakati pa 10 ndi akulu, mlingo woyambayo ndi 500 mg kapena 850 1 nthawi / tsiku kapena 500 mg 2 nthawi / tsiku. Ngati ndi kotheka, ndi nthawi osachepera 1 sabata, muyezo mutha kuchuluka mpaka 2 g / tsiku mu Mlingo wa 2-3.

Pambuyo masiku 10-15, mlingo uyenera kusinthidwa kutengera zotsatira za kutsimikiza kwa shuga m'magazi.

Kuphatikiza mankhwala ndi insulin, mlingo woyambirira wa metformin ndi 500-850 mg katatu / tsiku. Mlingo wa insulin umasankhidwa malinga ndi zotsatira za kutsimikiza kwa shuga m'magazi.

Kuchita

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, salicylates, ma inhibitors a MAO, oxytetracycline, zoletsa ACE, ndi clofibrate, cyclophosphamide, hypoglycemic zotsatira za metformin zimatha kupititsidwa patsogolo.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, njira yolerera ya mahomoni pakugwiritsira ntchito pakamwa, danazol, epinephrine, glucagon, mahomoni a chithokomiro, zotuluka za phenothiazine, zotupa za thiazide, zotumphukira za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Odwala omwe amalandila metformin, kugwiritsidwa ntchito kwa ayodini okhala ndi zotsutsana poyerekeza ndi mayeso (kuphatikizapo intravenous urography, intravenous cholangiography, angiography, CT) kumawonjezera chiopsezo cha kusokonekera kwa impso ndi lactic acidosis. Izi kuphatikiza ndi zotsutsana.

Beta₂-adrenomimetics mu mawonekedwe a jakisoni amawonjezera kuchuluka kwa shuga m'magazi chifukwa cha kukondoweza kwa β₂-makampani. Poterepa, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi. Ngati ndi kotheka, tikulimbikitsidwa kupereka insulin.

Kugwiritsa ntchito cimetidine mozungulira kungakulitse chiopsezo cha lactic acidosis.

Kugwiritsa ntchito munthawi yomweyo mankhwala a "loop" okodzetsa kungayambitse kukula kwa lactic acidosis chifukwa chakulephera kugwira ntchito kwaimpso.

Yofanana makonzedwe ndi Mowa kumapangitsa ngozi lactic acidosis.

Nifedipine imachulukitsa mayamwidwe ndi C_max metformin.

Mankhwala a Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim ndi vancomycin) omwe amatulutsidwa mu renal tubules kupikisana ndi metformin kwa machitidwe oyendetsa ma tubular ndipo angayambitse kuchuluka kwa C_max.

Zotsatira zoyipa

Kuchokera pamimba yogaya: kutheka (nthawi zambiri kumayambiriro kwa mankhwalawa) nseru, kusanza, kutsegula m'mimba, kuphwanya pansi, kumva kusasangalala pamimba, munthawi zina - kuphwanya kwa chiwindi, chiwindi (kutha pambuyo poti chithandizo chatha).

Kuchokera kumbali ya kagayidwe: kawirikawiri - lactic acidosis (kuleka kwa chithandizo ndikofunikira).

Kuchokera ku hemopoietic dongosolo: kawirikawiri - malabsorption a vitamini B₁₂.

Mbiri yamachitidwe osavomerezeka mu ana azaka zapakati pa 10 ndi akulu ndi chimodzimodzi pa akulu.

Type 2 matenda a shuga a mellitus (osadalira insulini) omwe ali ndi chithandizo chamankhwala komanso kupanikizika kochita masewera olimbitsa thupi, odwala omwe ali ndi kunenepa kwambiri: akuluakulu - monga monotherapy kapena osakanikirana ndi ena othandizira pakamwa kapena ndi insulin, mwa ana a zaka 10 kapena kuposerapo - monga monotherapy kapena kuphatikiza ndi insulin.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala amathandizidwa ndi dokotala yemwe amapanga njira yochizira ndikukhazikitsa mlingo woyenera. Ndizosatheka kugula mankhwala muchipatala popanda mankhwala. Malangizo ogwiritsira ntchito Metformin 1000 amaphatikizidwa phukusi lililonse. Musanamwe mankhwalawa, muyenera kuonetsetsa kuti muwerenga malangizo.

Mapiritsi amatengedwa pakamwa, osatafuna komanso kumwa madzi. Mankhwala atha kumwa kapena mutadya.Kwa akuluakulu, omwe ali ndi monotherapy kapena kuphatikiza kwa Metformin 1000 ndi mankhwala ena ochepetsa shuga, mankhwalawa otsatirawa amaloledwa:

• Pa gawo loyamba la chithandizo, amaloledwa kumwa mapiritsi a 0,5 (500 mg) katatu patsiku. Popita nthawi, mlingo wa mankhwalawa ukhoza kuchuluka kutengera kuchuluka kwa shuga m'magazi a wodwala.
• Kusamalira mankhwalawa kumapereka tsiku lililonse - 1500 mpaka 2000 mg, ndiye mpaka mapiritsi 2. Pofuna kupewa zoyipa zomwe zimakhudzana ndikusokoneza chimbudzi, tikulimbikitsidwa kugawa mankhwalawa katatu patsiku.
• Mlingo wapamwamba wa mankhwalawa ndi 3000 mg. Iyenera kugawidwa m'njira zitatu.

Ngati wodwalayo atasintha kuti asinthane ndi Metformin ndi mankhwala ena, muyenera kusiya kugwiritsa ntchito.

Pophatikiza mankhwalawa ndi mankhwala a insulin, odwala ambiri amatha kuwongolera zomwe zili m'magazi. Kumayambiriro kwa chithandizo, akulu amapatsidwa piritsi limodzi patsiku (1000 mg). Kwa ana (kuyambira azaka 10) ndi achinyamata, amaloledwa kumwa mankhwalawa mapiritsi 0,5 (500 mg) tsiku lililonse mu monotherapy komanso osakanikirana ndi insulin.

Pambuyo pa milungu iwiri yamankhwala, imasinthidwa potengera kuwunika kwa shuga. Mlingo woyenera kwambiri pakukula kwa achinyamata ndi mapiritsi awiri (2000 mg), ogawidwa pawiri. Dotolo amatipatsa mankhwala a odwala okalamba, poganizira zaumoyo wawo. Dokotala ayenera kusamala makamaka ngati ntchito ya impso ya wodwalayo imazirala pamene akumwa mankhwalawo. Kuti muwone ma pathologies, kusanthula kumapangidwa chifukwa cha kuchuluka kwa creatinine mu seramu yamagazi.

Njira yochizira imatha kutsimikiziridwa ndi dokotala wopita.

Contraindication ndi zoyipa

Pali zifukwa zina zomwe kugwiritsa ntchito mankhwalawa sikungatheke. Monga mankhwala ena, Meformin 1000 ili ndi zotsutsana zingapo:

1. Kusalolera kwamunthu aliyense payekha pazinthu zomwe zikugwira komanso zothandizira.
2. Mkhalidwe wa matenda ashuga, precoma, matenda ashuga ketoacidosis (kuphwanya kwa kagayidwe kazachilengedwe).
3. Kulephera kwina kapena kulephera kwa impso.
4. Mkhalidwe wamadzi, kusokonezeka, matenda.
5. Acute kapena matenda opatsirana omwe amakulitsa kupuma, mtima kulephera, kupweteka kwamtima.
6. Kutumiza kwa kulowererapo kwa opaleshoni, kukhalapo kwa kuvulala kambiri.
7. Kusokonezeka kwa chiwindi, chitukuko cha kulephera kwa chiwindi.
8. Kuzindikira thupi ndi zakumwa zoledzeretsa.
9. Kubereka ana komanso kunyamula mkaka.
10. Gwiritsani ntchito masiku awiri isanachitike komanso itatha mayeso a x-ray ndi radioisotope pogwiritsa ntchito ayodini.
11. Ana osakwana zaka 10.
12. Zakudya zamafuta ochepa-kashiamu zosakwana 1000 kcal patsiku.
13. Lactic acidosis (kudzikundikira kwa lactic acid).

Kugwiritsa ntchito molakwika mankhwala kapena mankhwala osokoneza bongo, wodwalayo amatha kukumana ndi zovuta:

• Matenda a metabolism, owonetsedwa ndi lactic acidosis. Vutoli limatha chifukwa cha malabsorption a vitamini B12.
• Kuphwanya kwamanjenje, chifukwa, kusintha kwa kukoma.
• Matenda am'mimba, owonetsedwa ndi mseru, kusanza, kupweteka kwam'mimba, kusowa kwa chakudya.
• Mkwiyo pakhungu, mwachitsanzo, totupa, erythema, kuyabwa.
• Kuphwanya chiwindi, mawonekedwe a chiwindi.

Zotsatira zoyipa zomwe zimadza kwambiri chifukwa chotenga Metformin ndi zovuta m'mimba. Amagwirizana ndi kupewa matumbo a m'mimba. Zotsatira zake, kupatsa mphamvu kwa chakudya kumayamba, zomwe zimathandiza kukulitsa zizindikiro zosiyanasiyana. Pakatha milungu iwiri mutagwiritsa ntchito mankhwalawa, mavuto omwewo amadzichitira okha. Kuti muchepetse zizindikiro, muyenera kuthana ndi mankhwalawa kangapo patsiku.

Kuphatikiza apo, kafukufuku wasonyeza kuti ana a zaka zapakati pa 10 mpaka 16 amakumananso ndi mavuto omwewa ngati omwe akulu amakhala nawo.

Kugwiritsa ntchito mankhwala ochepetsa

Aliyense amadziwa kuti kunenepa kwambiri kumayenderana ndi matenda a shuga. Chifukwa chake, odwala matenda ashuga ambiri omwe onenepa kwambiri sangathe kubwezeretsanso matendawa.

Koma kulimbana ndi kunenepa kwambiri kungakhalenso ndi vuto la shuga. Mankhwala Metformin 1000 amagwiritsidwa ntchito ndi odwala ambiri kuchepetsa thupi. Kuti mukhale ndi zotsatira zabwino komanso kupewa zovuta, munthu ayenera kutsatira malangizo angapo:

1. Pitilizani maphunziro anu osaposa masiku 22.
2. Khalani ndi moyo wokangalika.
3. Tenganso madzi ena ambiri.
4. Tsatirani zakudya ndipo muzikhala ndi chakudya.

Ngati wodwalayo akufuna kuchepa thupi komanso kuchepetsa shuga, ayenera kuchita masewera olimbitsa thupi tsiku lililonse. Kuyamba, kuyenda kwa mphindi 30 kumakhala kokwanira. Popita nthawi, mutha kusinthanitsa zochitika zapanja ndi masewera, kusambira padziwe, kuthamanga mmawa, Pilates, kulimbitsa thupi ndi zina zambiri.

Mukamagwiritsa ntchito mankhwalawa, zakudya zazing'ono ndizofunikira kwambiri. Mautumiki azikhala ochepa. Zakudya zamafuta, zakudya zokazinga, komanso zopatsa mphamvu zamagetsi zosafunikira ziyenera kuyikidwa pambali pazakudyazo. Zakudya za wodwalayo ziyenera kukhala ndi masamba ambiri ndi zipatso zosaphatikizika, zakudya zomwe zimakhala ndi michere yambiri komanso fiber.

Kudzilanga nokha pakadali pano sikofunika. Dotolo yekha ndi amene amatha kusankha mlingo woyenera wa mankhwalawo, atawunika momwe wodwalayo alili.

Kuphatikiza apo, Metformin 1000 imatha kutengedwa osati ndi anthu onenepa kwambiri, komanso owonda, omwe amakonda kuzala.

Ndemanga ndi mitengo yamankhwala

Metformin 1000 imatha kugulidwa ndi aliyense ku pharmacy iliyonse kapena kuyitanitsa pa intaneti. Mtengo wa mankhwalawa umatengera kaya ndi zapakhomo kapena zakunja. Popeza mankhwalawa ndi othandiza komanso otchuka padziko lonse lapansi, amapangidwa m'maiko ambiri. Mtengo wa Metformin 1000 umatengera dziko lomwe akupanga komanso kampani yopanga mankhwala. Chifukwa chake Metformin, yopangidwa pagawo la Russian Federation, imakhala ndi mtengo wokwanira kuyambira 196 mpaka 305 ruble, mankhwala omwe amapangidwa ku Slovakia m'dera la Russian Federation amatenga ma ruble 130. Zomwe zimachokera ku Hungary zimakhala ndi mitengo pafupifupi 314 rubles.

Titha kunena kuti mtengo wa mankhwalawo ndi wochepa, kuti aliyense athe kugula mankhwalawa. Ali ndi chinthu chachikulu - metformin, osiyana ndi wina ndi mnzake m'magawo othandizira okha. Wodwala aliyense amagula mankhwala potengera zochizira zomwe zimayembekezera komanso kuthekera kwazandalama. Kuphatikiza apo, mankhwala apakhomo ndi otsika mtengo, koma amakhala ndi zotsatira zake.

Zokhudza ogula za mankhwalawa, zimakhala zabwino. Kuunika kwa odwala ambiri kumawonetsa kuchepa kwenikweni kwa misempha ya shuga kukhala yofanana. Pankhaniyi, mankhwalawa amakwanitsa kupititsa muyeso wamagazi m'magazi ndi njira yayitali yothandizira. Pakati pazabwino za mankhwalawa, kugwiritsa ntchito mosavuta komanso mtengo wotsika kumasiyanitsidwa.

Ambiri odwala matenda ashuga akuti Metformin 1000 imathandiza kuthana ndi mapaundi owonjezera. Nthawi yomweyo, ena a iwo adakwanitsa kuchepetsa thupi chifukwa chotsatira malamulo onse munthawi yogwiritsa ntchito mankhwala osokoneza bongo. Kulephera kugwiritsa ntchito mapiritsi kungatengeke ndi zinthu monga kusakwanira kwa mankhwalawa, kusadya bwino kwa matenda ashuga, kudya mosafunikira kwa mankhwalawa, komanso kusazindikira tanthauzo la mankhwalawa.

Mankhwalawa ali ndi zovuta zina. Amaphatikizidwa ndi kupezeka kwa zoyipa, makamaka kugaya kwam'mimba, thupi la munthu likazolowera zochita za hypoglycemic wothandizira.

Nthawi zambiri, izi zimachitika zokha.

Othandizira a hypoglycemic omwe

Chifukwa cha kutchuka kwake, Metformin ili ndi mavumikidwe ambiri. Kukonzekera kofananira komwe kumakhala nako kogawana kungasiyane pokhapokha. Mankhwalawa akuphatikizapo:

Mndandandawu ukhoza kuwonjezeredwa ndi ndalama zambiri zofananira. Anthu ambiri amadabwa kuti ndi mapiritsi ati omwe ndi abwino kusankha. M'malo mwake, palibe kusiyana kwakukulu, popeza gawo lalikulu limapezeka mumankhwala onsewa. Chifukwa chake, chomwe chimakhudza kusankha kwa mankhwala ndi mtengo wake.

Ngati mankhwalawa Metformin 1000 sangakhale oyenera kwa wodwalayo, zomwe zimapangitsa kuti ayambe kudwala, dokotalayo amatha kusintha mankhwalawa popereka mankhwala ena. Mwachitsanzo:

1. Siofor ndi mankhwala abwino kwambiri ochepetsa shuga omwe amatha kuphatikizidwa ndi mankhwala ena monga salicylate, sulfonylurea, insulin ndi zina zambiri. Ndi chithandizo chovuta ndi mankhwalawa, zotsatira zake zimasintha. Mtengo wapakati wamankhwala (1000 mg) ndi ma ruble 423.
2. Glucophage ndi mankhwala ena othandiza omwe ali ndi vuto la hypoglycemic. Kafukufuku waposachedwa akuwonetsa kuti kumwa mankhwalawa kumachepetsa chiyembekezo chakufa ndi matenda ashuga ndi 53%, mwayi wakuphwanya myocardial - ndi 35%, ndi stroke - ndi 39%. Pafupifupi, mankhwala (850 mg) angagulidwe kwa ma ruble 235.
3. Diagnizide ndi mankhwala omwe amachepetsa kukana kwa insulin ndikuwonjezera mphamvu ya kutsitsa kwa shuga - insulin. Gawo lalikulu la mankhwalawa limakhudzana ndi zotumphukira za sulfonylurea. Mankhwalawa sangatengedwe ndi uchidakwa wambiri, kutenga phenylbutazone ndi danazole. Mtengo wapakati wa mankhwalawa (2 mg, mapiritsi 30) ndi ma ruble 278.
4. Guwa lili ndi gawo limodzi - glimepiride, yomwe imatulutsa insulin ndi maselo a beta a kapamba. Chifukwa chake, chida ichi chimagwiritsidwa ntchito pochiza matenda a shuga ndi kunenepa kwambiri. Kuphatikiza apo, mankhwalawa ali ndi zovuta zambiri zomwe zimaganiziridwa musanagwiritse ntchito. Mtengo wapakati wa mankhwala (3 mg, 30 ma PC.) Ndi 749 rubles.

Chifukwa chake, Metformin 1000 ndi othandizira a hypoglycemic omwe adziyambitsa okha bwino kwambiri m'maiko ambiri padziko lapansi. Kugwiritsa ntchito kwake kumatheka pokhapokha mukaonana ndi dokotala, popeza mankhwalawa ali ndi zotsutsana zina komanso zotsutsana. Pogwiritsa ntchito mapiritsi molondola, wodwala matenda ashuga angaiwale za vuto la hyperglycemia kwa nthawi yayitali ndipo amatha kutaya mapaundi owonjezera.

Mu kanema munkhaniyi, a Elena Malysheva, pamodzi ndi akatswiri, adzalankhula za Metformin.

Kuchiza ndi kupewa matenda a shuga a 2

Metformin imachepetsa glycemia, potero amateteza ziwalo kuti zisawonongeke mpaka kalekale, zomwe zingapangitse kuti azikhala ndi vuto kapena azigwira ntchito kwakanthawi. Mankhwalawa amagwira ntchito kudzera pa AMPK, yomwe imayambitsa kuyamwa kwa shuga m'magazi kupita m'minyewa. Metformin imakulitsa AMPK, yomwe imalola minofu kugwiritsa ntchito glucose yambiri, yomwe imachepetsa kuchuluka kwa shuga m'magazi.

Kuphatikiza apo, metformin imatha kuchepetsa shuga m'magazi poletsa kupanga kwake (gluconeogeneis).

Kuchuluka kwa insulin

Kukana kwa insulini ndi chinthu chomwe chimayambitsa kukula kwa matenda a shuga a 2, komanso kuwonedwa mu polycystic ovary syndrome komanso ngati njira imodzi yothandizira pakulimbana ndi HIV.

Mankhwalawa amathandizira chidwi cha insulin komanso amawonetsa zotsatira za kukana kwa insulin mwa anthu odwala matenda a shuga.

Kulimbana Zizindikiro za PCOS

Polycystic Ovary Syndrome (PCOS) ndi vuto la mahomoni lomwe nthawi zambiri limachulukitsidwa chifukwa cha kunenepa kwambiri komanso kukana insulini. Metformin imalepheretsa kudumphira kwa ovulation, kusamba kwa msambo komanso insulin yambiri mthupi. Zimawonjezera mwayi wokhala ndi pakati wopambana komanso zimachepetsa chiopsezo cha kutenga pathupi. Amachepetsa kuchepa kwa matenda ashuga komanso kutupa komwe kumayenderana ndi polycystic ovary syndrome.

Metformin imawonjezera mwayi wokhala ndi pakati wopambana komanso imachepetsa chiopsezo cha kutenga pathupi.

Titha kupewa khansa kapena kugwiritsa ntchito mankhwalawa

Metformin adayimitsa kukula ndikukula kwa mitundu ina ya khansa odwala oposa 300,000 omwe ali ndi matenda amtundu wa 2.

Kufufuza kwa meta kunawonetsa kuchepa 60% mu chiwopsezo cha matenda a chiwindi a oncological (intrahepatic cholangiocarcinoma) mwa anthu odwala matenda a shuga omwe adalembedwa kuti metformin. Kafukufukuyu akuwonetsa kuchepa kwa kuthekera kwa khansa ya pancreatic ndi m'mawere, khansa ya m'matumbo ndi m'mapapo ndi 50-85%.

Kodi kiwi ndizothandiza kwa odwala matenda ashuga? Werengani zambiri mu nkhaniyi.

Amachepetsa cholesterol

Metformin imatsitsa cholesterol "yoipa", yotsika lipoproteins (LDL).

Zimathandizira kuwonda

Pakufufuza komwe azimayi azaka zapakati omwe amakhala ndi insulin yayikulu molingana ndi shuga wamagazi ndi kulemera kwa thupi adatengedwa, zidapezeka kuti metformin imathandizira kuchepetsa thupi.

Pakufufuza kwina, metformin yachepetsa kuchuluka kwa thupi mwa odwala 19 omwe ali ndi kachilombo ka HIV omwe amagawa mafuta ochulukirapo (lipodystrophy).

Tetezani ku zowonongeka zomwe zimayambitsa glamicin

Gentamicin ndi maantibayotiki omwe amachititsa kuwonongeka kwa impso ndi makina owonera. Metformin imatha kuteteza kutayidwa kwamakutu komwe kumayamba chifukwa cha kuyamwa.

Kuchepetsa thupi

Amakhulupirira kuti mankhwalawa amatha kuthandizira kuchepetsa thupi. Komabe, asanagwiritse ntchito, upangiri waukatswiri umafunika.

Dongosolo la Endocrine

Pali kuthekera kwa hypoglycemia.

Thupi lawo siligwirizana.

Malangizo apadera

Mankhwalawa sangathe kugwiritsidwa ntchito masiku awiri asanachitike opaleshoni komanso maola 48 atatha (pokhapokha ngati wodwalayo ali ndi ntchito yofanana ndi impso).

Ndikulimbikitsidwa kuti kuyesedwa kuchitike pafupipafupi kuti muchepetse matenda a shuga.

Musanagwiritse ntchito, ndikofunikira kudziwa nokha momwe mungagwiritsire ntchito.