Kuwunika kwa mankhwala a statin kuti muchepetse cholesterol

Ma statins a m'badwo waposachedwa amadziwika kuti ndi mankhwala othandiza komanso otetezeka polimbana ndi zovuta za atherosulinosis. Mankhwala osokoneza bongo amathandizira kuchepetsa cholesterol, komanso zinthu zina zamafuta metabolism. Kutenga ma statins kumachedwetsa kukhala ndi vuto la mtima - mtima, kugunda.

Matenda a mtima amatenga malo oyamba pakati pazomwe zimayambitsa kufa. Malinga ndi Unduna wa Zaumoyo, mu 2017, 47.8% ya nzika zaku Russia zidamwalira ndi matenda a mtima. WHO ilosera kuti chiwerengerochi chidzachuluka chifukwa cha kukalamba pang'onopang'ono, komanso kusintha kwa moyo.

Madera: ndi chiyani, amene wapatsidwa ntchito

Statins ndi mankhwala omwe amalepheretsa biosynthesis ya cholesterol m'chiwindi, m'malo mwa HMG-CoA reductase enzyme. Chifukwa chake, dzina lawo lovomerezeka ndi HMG-CoA reductase inhibitors. Kuphatikiza apo, ma statins amachepetsa kuchuluka kwa lipoproteins "zovulaza" (LDL), kuwonjezera kuchuluka kwa lipoproteins "zabwino".

Matenda a ndende ya cholesterol, LDL, HDL amathandizira kupewa kupita kwa atherosulinosis, zovuta zake: kugunda kwa mtima, kugunda, necrosis yam'munsi. Pamodzi ndi thrombosis komanso matenda oopsa, matendawa amadziwika kuti ndiwoopsa kwambiri pamitsempha yonse ya mtima.

Ku Europe, USA, chizolowezi chopangira ma statins ndizofala kwambiri. 95% ya aku America, 55% ya odwala aku Europe omwe amapatsidwa mankhwala, amawatenga. Ku Russia, chiwerengerochi ndi 12% chokha. Kafukufuku wina wapadziko lonse lapansi, VALIANT, adawonetsa kuti madokotala amatipatsa mankhwala ochulukitsa nthawi 100 kuposa antchito awo akunja.

Kulemba ma statins kumakupatsani mwayi:

• chepetsa chiopsezo cha matenda a mtima, sitiroko,
• kuchepetsa kuchuluka kwa odwala omwe ali ndi vuto lodana ndi mtima lakufuna kuchipatala,
• sinthani kuchuluka kwa maopareshoni kuti mubwezeretse magazi,
• kupewa angina.

Ngakhale kuthekera kwakukulu kwakuchiritsa, mapiritsi a statin amatengedwa kuti awonetse momveka bwino, osati kuwonjezereka kwa cholesterol. Si owopsa, amakhala ndi zotsatirapo zoyipa. Ma Statins akulimbikitsidwa anthu:

• opulumuka nthenda ya mtima, sitiroko, micostroke,
• kukonzekera opareshoni yamatumbo apamtunda,
• ndi milingo ya LDL yochulukirapo ya 190 mg / dL (4.9 mmol / L),
• akudwala matenda a shuga komanso kukhala ndi ndende ya LDL ya 70-189 mg / dl (1.8-4.9 mmol / l),
• Ana opitirira zaka 10 omwe ali pachiwopsezo cha kudwala mtima.

Atorvastatin

Chiwerengero chogulitsa kwambiri padziko lapansi. Mwa mphamvu, ili patsogolo pa mankhwala oyamba (simvastatin, pravastatin, lovastatin). Kugwiritsa ntchito kwake mwa odwala ambiri kumakupatsani mwayi woti muchepetse cholesterol yomwe ikukulirakulira mpaka mulingo woyenera. Nthawi yomweyo, mtengo wamapiritsi umachepa kwambiri poyerekeza ndi rosuvastatin, ndipo kulolerana kwa odwala ambiri kuli bwino.

Rosuvastatin

Mankhwalawa amawonedwa ngati amphamvu kwambiri pazomwe zilipo. Rosuvastatin amalembedwa pazochitika zapamwamba kwambiri, poika mankhwala ena osaloledwa kukwaniritsa kutsika koyenera kwa cholesterol, LDL. Masiku ano palibe mgwirizano pazomwe zimagwiritsidwa ntchito mwa odwala omwe ali ndi hypercholesterolemia, chiopsezo chochepa cha matenda a mtima. Mankhwalawa adatulutsidwa posachedwapa, ntchito yake yaphunziridwa moyipa kuposa atorvastatin. Chifukwa chake, mafunso ena, makamaka ngati akukhudzana ndi zotsatira zazitali, palibe yankho lenileni.

Pitavastatin

Mankhwala osowa kwambiri a 4th, omwe amapangidwa ndi kampani yaku Spain Recordati Viwanda Chemist Pharmaseutics ogulitsa Livazo. Poyerekeza ndi rosuvastatin wotchuka, waphunziridwa kwambiri. Chifukwa chake, madokotala amapereka mankhwala a pitavastatin kuti achepetse cholesterol yochepa. Nthawi zambiri amamuikira odwala monga njira ina ya rosuvastatin pofuna kutsutsana. Mtengo wa Livazo ndi ma ruble 540-1205.

Status a m'badwo wotsiriza: mayina a mankhwala a 3, mibadwo 4 akuwonetsedwa patebulopo.

Ndi mtundu uti wa mibadwo yaposachedwa kwambiri womwe uli ndi zotsatira zoyipa zochepa? Malo otetezeka kwambiri ndi ma statins Liprimar (atorvastatin), Crestor (rosuvastatin). Mtengo wawo ndi wosiyana kwambiri ndi ma analogu, koma ndi woyenera. Ngati bajeti ya wodwalayo ili yochepetsetsa, amaikidwa m'malo mwake ndi mbiri yabwino: Tulip, Torvakard, Atoris, Rosucard, Lipoprime. Dokotala atha kukulemberani mankhwala ena kutengera zomwe akudziwa ndi mankhwalawo. Osagula okonda zotsika mtengo. Kuchita kwawo, chitetezo chiri kukayikira.

Kusiyana pakati pa mankhwala am'badwo watsopano ndi wakale

Pali mibadwo 4 ya ma statins:

• yoyamba ndi simvastatin, lovastatin, pravastatin,
• Lachiwiri ndi fluvastatin,
• chachitatu ndi atorvastatin,
• wachinayi ndi rosuvastatin, pitavastatin.

Rosuvastatin nthawi 1.5-2 bwino amachepetsa LDL kuposa atorvastatin, nthawi 4 kuposa simvastatin, nthawi 8 kuposa pravastatin kapena lovastatin. Kuphatikizika kwa lipoproteins "yowopsa" kumawerengedwa ngati chisonyezo chachikulu chomwe chimakhudza kuchepetsedwa kwa chiwopsezo cha zovuta zamtima. Amagwiritsidwa ntchito kuneneratu za mankhwalawa.

Kagayidwe ka ma statins a m'badwo wotsiriza ndi ofanana ndi mankhwala a mibadwo 1-2, koma ndi zovuta zina. Izi zimakuthandizani kuti muwalembe nthawi imodzi ndi mankhwala ena omwe sagwirizana ndi simva-, nsomba, pravastatin. Mwayiwu umakulitsa kwambiri gulu la odwala omwe angathe kukhala nawo.

Kusiyanitsa kwakukulu pakati pa ma statins a m'badwo waposachedwa ndikutha kutsitsa kuchuluka kwa mapuloteni a C-reactive (CRP factor). Kafukufuku watsopano akukakamiza madokotala kuti azindikire kuti chinthu ichi sichingakhale ndi gawo lililonse pakukula kwa atherosulinosis kuposa cholesterol. Matenda a mtundu wake umakupatsani mwayi wolepheretsa chitukuko, komanso kupewa mavuto obwera chifukwa chowononga moyo. Nyumbayi mwachidziwikire imangopezeka mu rosuvastatin, komanso mawonekedwe ake.

Zina zomwe zimagwirizana ndi mankhwala

Mapiritsi a m'badwo wachitatu ndi wachinayi amagwirizana bwino ndi mankhwala ena. Atorvastatin sangathe kulembedwa nthawi imodzi ndi:

• gemfibrozil,
• kuphatikiza kwa tipranavir ndi ritonavir,
• telaprevir
• cyclosporine.

Malangizo a mapiritsi ndi ofunikira mukamamwa mankhwala otsatirawa:

• boceprivir,
• verapamil
• digoxin
• diltiazem
• itraconazole,
• madalin,
• colchicine
• lopinavir ndi ritonavir,
• nelfinavir
• niacin
• omeprazole
• ezetimibe.

Mapiritsi a Rosuvastatin amasiyana ndi ma statin ena polumikizana pang'ono ndi ma enzymes a cytochrome P450. Itha, koma yosafunikira, itha kutumizidwa ngati yowonjezera pamankhwala omwe mankhwala ena a HMG-CoA reductase inhibitors sagwirizana. Kukonzekera kwa Rosuvastatin sikumaperekedwa kwa odwala omwe amatenga fibrate, cyclosporine.

Ubwino ndi kuvulaza kwa ma statins

Mankhwala omwe amapezeka m'mibadwo yatsopano ya cholesterol yapamwamba ndi zifukwa zomveka ngati pali umboni. Malinga ndi kafukufuku, kugwiritsa ntchito rosuvastatin kutha kuchepetsedwa ndi:

• 20% yakufa konse,
• 44% yakufa chifukwa cha zovuta za atherosulinosis,
• 50% mwayi wokhala ndi stroke, matenda a mtima.

Ma statin ena amatha kudzitamandira modzichepera, komabe zotsatira zabwino. Cholinga chawo chitha kuchepetsedwa ndi:

• 20-42% akufa pamatumbo,
• 25-37% ya obwera chifukwa cha myocardial infaration,
• 28-31% mwayi wa stroke.

Tsoka ilo, ma statin sakhala otetezeka kwathunthu. Mapiritsi amakhala ndi zovuta zambiri, zingapo zotsutsana. Sizolembedwa kwa anthu omwe:

• matenda a chiwindi
• ana (kupatula - nthenda yachilengedwe yachilendo, yomwe imayendera limodzi ndi cholesterol yayikulu),
• amayi apakati, komanso amayi amene akufuna kubereka,
• kunyambita.

Zotsatira zake zoyipa sizowopsa. Pafupifupi 12% ya odwala ali ndi zilonda zapakhosi, 6.6% ya mutu, 5.3% yazizindikiro ngati chimfine, 5.1% ya kupweteka kwa minofu. Odwala ambiri amafotokoza za kusintha kwamankhwala ambiri akamamwa mankhwalawo pakatha masiku angapo kapena milungu ingapo. Koma anthu ena amapitilizabe kukumana ndi maphunziro onse.

Njira yotsogola kwambiri yochotsera mavuto ndi kusiya ma statins. Asanaganize zosiya chithandizo, madokotala amalimbikitsa kupima zabwino ndi zovuta zake. Kupatula apo, ma statins amakulitsa moyo wa munthu, ndipo ndichabwino kupirira ndikusokonekera kwazing'ono kuti akhale ndi moyo wabwino. Kuphatikiza apo, pali njira zina zomwe zingathandizire ena:

• vomerezani yopuma yayifupi pakumwa mankhwalawo. Onani zosintha. Nthawi zina kupweteka kwa minofu, kufooka kwathunthu kumachitika chifukwa cha ukalamba kapena matenda ena, osati zotsatira zoyipa za mankhwala. Njira zawo zimathandizira,
• Funsani dokotala wanu kuti alowe m'malo mankhwalawo kapena kuti muchepetse ntchito. Ma Statin ndi gulu lalikulu la mankhwala, omwe amalola kuti wodwala aliyense asankhe mankhwala omwe angamuthandize,
• fotokozerani kuphatikiza kwa ma statins ndi mankhwala ena ochepetsa cholesterol. Ma Statin ndi mankhwala othandiza kwambiri kusintha misempha ya cholesterol. Koma nthawi zina, kuphatikiza kwawo ndi mankhwala ena kumachepetsa mlingo, kusunga mulingo wa LDL wotsika.
• chita masewera olimbitsa thupi mosamala. Zochita zolimbitsa thupi zitha kuvulaza minofu pamaselo a ma cell. Poyerekeza ndi kumbuyo kwa kutenga HMG-CoA reductase inhibitors, izi zimakhala ndi zowawa kwambiri. Kungakhale koyenera kubwereza dongosolo la maphunziro pochepetsa pang'ono katundu,
• kutenga coenzyme Izi zowonjezera zakudya zimathandiza kupewa zovuta zina mwa anthu ochepa.

Amakhulupirira kuti zoletsa za HMG-CoA reductase zimatha kuyambitsa matenda ashuga. Izi ndizowona. Kafukufuku wamkulu wa JUPITER adachitika, pomwe mkhalidwe waumoyo wa odwala 17 802 omwe adatenga rosuvastatin adawunikiridwa. Type 2 shuga mellitus yomwe idapangidwa mu 270 odwala omwe amamwa mapiritsi, motsutsana ndi 216 milandu yokhudzana ndi matenda pakati pa iwo omwe adamwa. Madotolo akufotokozera kuwonjezeka pang'ono kwa kuthekera kokulirapo kwa anthu m'gulu lofufuzaku pakukula kwa matenda ashuga.

Chifukwa chiyani cholesterol ikukwera?

Cholesterol ndi gulu lachilengedwe lomwe limapezeka m'thupi ndipo limagwira ntchito yake. Ndi gawo lofunikira la lipid metabolism.

Kuzindikira kwa zinthu kumatha kupitilira muyeso womwe unakhazikitsidwa. Izi zimasokoneza thanzi komanso zimayambitsa matenda angapo. Izi zimaphatikizapo kugunda kwa mtima ndi stroko, angina pectoris, atherosulinosis.

20% ya cholesterol yakunja imachokera ku chakudya, 80% yotsalayo imapangidwa ndi thupi. Pophwanya lamulo la kudya ndi kutulutsa chinthu, zinthu zake zimasintha.

Zoyambitsa mkati ndi zakunja zimapangitsanso kuti mafuta azikhala ndi mafuta ambiri:

• kagayidwe kachakudya
• chibadwire
• Zakudya zopitilira muyeso zokhala ndi mafuta a nyama,
• kugwiritsa ntchito mankhwala ena
• matenda oopsa
• kupsinjika kwakanthawi
• matenda ashuga
• kusowa zolimbitsa thupi
• kusasamala kwa mahomoni kapena kukonza,
• kunenepa kwambiri komanso kunenepa kwambiri
• ukalamba.

Zisonyezo zakusanthula kwa labotale ndi:

• kuzindikira kwa atherosclerosis ndi kupewa kwake pangozi
• kukhalapo kwa mitundu ina yamatenda amtima,
• matenda a impso
• matenda a endocrine - hypothyroidism,
• matenda ashuga
• matenda a chiwindi.

Ngati zovuta zapezeka, dokotala amakupatsani njira zingapo zochepetsera cholesterol. Mankhwala a Statin amatha kuperekedwa malinga ndi chithunzi cha chipatala.

Kodi ma statins ndi ati?

Ili ndi gulu la mankhwala ochepetsa lipid omwe amapangidwira kuti muchepetse cholesterol yoyipa. Amaletsa ntchito ya chiwindi, yomwe imakhudzidwa ndikupanga zinthu.

Statins amatengedwa ngati mankhwala othandizira kupewa matenda oyamba ndi obwereza pamtima. Gulu la mankhwala limasinthasintha magawo amitsempha yamagazi ndikuletsa mapangidwewo.

Ndi mankhwala okhazikika, odwala amatha kutsitsa cholesterol ndi 40%. Malinga ndi ziwerengero, amachepetsa kufa kwa matenda a mtima ndi pafupifupi kawiri.

Mankhwalawa amachepetsa mphamvu ya mafuta m'thupi, amachepetsa kaphatikizidwe ka lipoproteins ndi chiwindi, amatulutsa magazi, kuchepetsa kukongola kwake, kukulitsa kuchuluka kwa mitsempha yamagazi, kumasuka ndikukula, ndikulepheretsa mapangidwe a zipupa pamakoma.

Kutenga nthawi yayitali bwanji? Mankhwalawa amachita pokhapokha kuti alandire, atatsiriza, zizindikiritso zimatha kubwerera ku ziwerengero zam'mbuyomu. Kugwiritsira ntchito kosatha sikuchotsedwa.

Zizindikiro zogwiritsidwa ntchito

Zisonyezero zakugwiritsa ntchito ma statins kutsitsa cholesterol:

• hypercholesterolemia,
• kwambiri atherosclerosis ndi kuopsa kwa kukula kwake,
• kupewa koyipa kwa mikwingwirima, mtima,
• kukonza mankhwala pambuyo sitiroko, mtima,
• ukalamba (kutengera kusanthula)
• angina pectoris
• Matenda a mtima wa Ischemic,
• chiopsezo chotchinga mitsempha yamagazi,
• homozygous cholowa (achibale) Hypercholesterolemia,
• kuchitapo kanthu kwa mtima ndi mitsempha yamagazi.

Mwa zina zotsutsana ndi ma statins:

• kukanika kwa impso
• tsankho pamagawo ena
• mimba
• kuyamwitsa
• Hypersensitivity zimachitika
• wazaka 18.

Mndandanda wa mankhwala a statin

Mankhwala a Statin amayimilidwa ndi mibadwo 4.

Iliyonse mwa iwo muli zinthu zomwe zimatchulidwa ndi nthawi ya kukhazikitsa:

1. M'badwo woyamba - Lovastatin, Simvastatin, Pravastatin. Zoyambira ndi zachilengedwe. Ntchito yochepetsa cholesterol ndi 25%. Ndiwosagwira pamtengo wotsika ndipo amatha kuwonetsa zovuta zake. M'badwowo ukuyimiriridwa ndi mankhwala otsatirawa: Vasilip - 150 r, Zokor - 37 r, Lovastatin - 195 r, Lipostat - 540 r.
2. Mbadwo wachiwiri ndi fluvastatin. Zoyambira zake ndi zapawiri. Zizindikiro zochepera pa ntchito - 30%. kuchitapo kanthu kwakutali komanso kuchuluka kwa zisonyezero kuposa otsogola. Mayina a 2nd mankhwala: Leskol ndi Leskol Forte. Mtengo wawo ndi pafupifupi 865 p.
3. Mbadwo wachitatu ndi Atorvastatin. Chiyambi chake ndichopangidwa. Ntchito yochepetsera kugwiritsidwa ntchito kwa zinthuzo mpaka kufika pa 45%. Chepetsani msanga LDL, TG, onjezani HDL. Gulu la mankhwalawa limaphatikizapo: Atokor - rubles 130, Atorvasterol - 280 p, Atoris - 330 p, Limistin - 233 p, Liprimar - 927 p, Torvakard - 250 p, Tulip - 740 p, Atorvastatin - 127 p.
4. Mbadwo wachinayi ndi Rosuvastatin, Pitavastatin. Chiyambi chake ndichopangidwa. Ntchito yochepetsa cholesterol ili pafupifupi 55%.M'badwo wokalamba kwambiri, wofanana mu kuchitapo chachitatu. Sonyezani njira zochizira pamunsi. Kuphatikizidwa ndi mankhwala ena a mtima. Otetezeka komanso wothandiza kuposa mibadwo yakale. Gulu la 4th la mankhwala limaphatikizapo: Rosulip - 280 r, Rovamed - 180 r. Tevastor - 770 p, Rosusta - 343 p, Rosart - 250 p, Mertenil - 250 p, Crestor - 425 p.

Zokhudza thupi

Mankhwala a Statin amathandiza odwala omwe ali ndi matenda amtima. Amachepetsa kutupa m'matumbo, cholesterol, amachepetsa kuopsa kwa matenda a mtima ndi stroko. Mankhwala amathandizanso kuyambitsa mavuto ambiri kuchokera kwaofatsa mpaka kwambiri.

Popeza mapiritsi amatengedwa nthawi yayitali, chiwindi chimakhala pachiwopsezo. Mothandizidwa ndi mankhwalawa, kangapo pachaka, kuphatikiza magazi kumachitika.

Zotsatira zoyipa za mankhwala zimaphatikizapo:

• mawonekedwe owopsa a khungu,
• mutu ndi chizungulire,
• kufooka kowonjezereka ndi kutopa,
• matenda am'mimba
• zotumphukira neuropathy,
• chiwindi
• kuchepa kwa libido, kusabala,
• kupweteka m'mimba
• zotumphukira edema,
• kusamalira chidwi, kuiwalaiwala kwamigawo yosiyanasiyana,
• thrombocytopenia
• kufooka kwa minofu ndi kukokana
• mavuto a chiwindi
• myopathy
• amnesia wapadziko lonse lapansi - kawirikawiri,
• rhabdomyolysis sichisowa.

Ndi mankhwala ati oti musankhe?

Statin ndi gulu lamankhwala amphamvu. Sangapangidwe kuti azidzipiritsa nokha. Amangotchulidwa ndi dokotala wokhazikika, poganizira kuopsa kwa matendawa komanso zotsatira za kafukufuku. Zimatengera kuopsa konse komwe kumachitika chifukwa cha ukalamba, matenda opatsirana, kumwa mankhwala ena.

Pakupita miyezi isanu ndi umodzi, kusanthula kwa zamankhwala kumaperekedwa mwezi uliwonse kuti kuwunikire zizindikiro za chiwindi. Maphunziro owonjezereka amachitika katatu pachaka.

Kodi mankhwalawa amasankhidwa bwanji? Dokotala amasankha mankhwalawo ndikupereka maphunzirowo. Mukamaliza, zizindikiro zimayang'aniridwa. Palibe mphamvu, ndi osakwanira Mlingo, kuwonetsedwa kwa zoyipa, pakhale mankhwala ena. Atatenga mankhwala ofunikira, chiwembucho chakhazikika.

Zotsatira zoyipa, kuphatikiza ndi mankhwala ena, nthawi yoyendetsedwa imayang'aniridwa. Ziwerengero za m'badwo wotsiriza zimadziwika kuti ndizabwino kwambiri. Amawonetsa kuyendetsa bwino chitetezo ndikuchita bwino.

Pafupifupi palibe vuto ndi kagayidwe ka glucose, pitani bwino ndi mankhwala ena a mtima. Pochepetsa mulingo (ndi zotsatira zake), zoopsa zomwe zimapangitsa kukhala ndi mavuto zimachepa.

Nkhani ya kanema yochokera kwa Dr. Malysheva wonena za ma statins:

Malingaliro odwala

Ndemanga za odwala zimawonetsa kukhalapo kwa mfundo zabwino komanso zoyipa pochizira ma statins. Ambiri amati polimbana ndi cholesterol yayikulu, mankhwala amawonetsa zotsatira zowoneka. Zotsatira zoyipa zambiri zidadziwikanso.

Ndemanga za madotolo za ma statins ndi osakanikirana. Ena amati ndi othandiza komanso kupitilira kwawo, pomwe ena amati ndi zoyenera.

Anandipatsa Atoris kuti ndichepetse cholesterol. Mutatha kumwa mankhwalawa, chizindikirocho chatsika kuchoka pa 7.2 mpaka 4.3. Chilichonse chinkawoneka ngati chikuyenda bwino, kenako kutupikira modzidzimutsa, kuphatikizanso kupweteka kwa mafupa ndi minofu kunayamba. Tolerate sanakhale woleza. Chithandizo chake chidayimitsidwa. Patatha milungu iwiri, zonse zidapita. Ndipita kukakumana ndi adotolo, mumulole kuti akupatseni mankhwala ena.

Olga Petrovna, wa zaka 66, Khabarovsk

Abambo anga adasankhidwa kukhala Crestor. Ndi m'badwo wotsiriza wama statins, wabwinobwino kwambiri kuposa onse. Pambuyo pake panali Leskol, panali zowonjezereka. Abambo adamwa Krestor pafupifupi zaka ziwiri. Zimawonetsa zotsatira zabwino, ndipo mbiri ya lipid imakwaniritsa miyezo yonse. Nthawi zina pamakhala chimbudzi chokha. Dokotala wopezekayo akuti zotsatira zake zimakhala zabwino kwambiri kuposa momwe amayembekezera. Pofuna kupulumutsa ndalama, sitikufuna kusinthitsa ndalama zotsika mtengo.

Oksana Petrova, wazaka 37, St. Petersburg

Apongoziwo akhala akutenga zaka 5 pambuyo pogwidwa kwambiri. Nthawi zingapo anasintha mankhwalawo. Wina sanatsike cholesterol, winayo sanakwanitse. Pambuyo posankha mosamala, tinaima ku Akorta. Mwa mankhwala onse, adapezeka kuti ali abwino kwambiri okhala ndi zotsatira zoyipa zochepa. Apongozi awo nthawi zonse amawunika momwe chiwindi chimakhalira. Mayeserowa samakhala nthawi zonse. Koma kwa iye, palibe chosankha.

Alevtina Agafonova, wazaka 42, Smolensk

Dotolo adandiuza Rosuvastatin kwa ine - adati m'badwo uwu ndiwo wabwino koposa, wokhala ndi zovuta zochepa. Ndinawerenga malangizo oti agwiritse ntchito, komanso kuchita mantha pang'ono. Pali ma contraindication ambiri komanso zoyipa kuposa mawonekedwe ndi mapindu. Zikhala kuti timachitira imodzi, ndi kulumala inayo. Ndinayamba kumwa mankhwalawo, ndimamwa kwa mwezi umodzi, mpaka pano osapitirira muyeso.

Valentin Semenovich, wazaka 60, Ulyanovsk

Ma Statin ndi ofunika kwambiri mu atherosulinosis, kugunda kwa mtima, komanso stroko. Tsoka ilo, nthawi zina munthu sangathe popanda iwo. Mankhwala sangathetse vuto lathunthu poletsa zovuta. Koma zinthu zina zikuyenda bwino.

Agapova L.L., katswiri wamtima

Statin ndi gulu la mankhwala omwe ali pamndandanda wa mankhwala ofunikira polimbana ndi cholesterolemia ndi zotsatira zake. Ndi chithandizo chawo, ndizotheka kuchepetsa anthu omwe akuvutika ndi mikwingwirima ndi matenda a mtima. Mbadwo wachinayi umawonedwa ngati wothandiza kwambiri komanso wotetezeka.

Ma Statin - ndi chiyani

Statins ndi gulu la mankhwala omwe amapangidwa kuti achepetse cholesterol yamagazi. Koma mankhwalawa samukhudza mwachindunji. Zimakhudza chiwindi, kulepheretsa kubisika kwa enzyme yomwe imakhudzidwa ndikupanga cholesterol.

Mu thupi la munthu muli ziwalo zake - lipoproteins. Amakhala ndi malo ochulukirapo komanso otsika. Ngati njira za metabolic sizisokonezeka, ndiye kuti ma lipoprotein sakuwaika pachiwopsezo chaumoyo. Koma kuphatikiza cholesterol yochulukirapo kumathandizira kupanga mapangidwe am'madzi, omwe amatsogolera pakupanga matenda oopsa.

Statin cholinga chake ndi kuchepetsa kuchuluka kwa cholesterol chonyamula zimakhala. Nthawi yomweyo, kuchuluka kwa zolimba kwambiri za lipoprotein receptors pa hepatocytes kumachulukana. Mwakutero, amasamutsa cholesterol mbali inayo - kuchokera kukayenda kwa magazi kupita ku chiwindi. Chifukwa cha mankhwalawa, kupanga mafuta m'thupi kumapangidwanso. Kugwiritsa ntchito kwawo kumapangitsa kuti zinthu zake zizikhala bwino.

Zofunika! Cholesterol choti mutenge ma statins? Ndizofunikira kwa munthu wokhala ndi chizindikiro pamwamba pa 5 mmol / l. Pambuyo pang'onopang'ono infarction, mu kwambiri matenda a mtima, chidwi cholesterol zili amachepetsa.

Zomwe zimagawidwa ndi ma statins

Pali njira zingapo zopatulira ma statins:

1. Kwa mibadwo: m'badwo woyamba, wachiwiri, wachitatu komanso wotsiriza.
2. Zoyambira: zopangidwa, zopangira theka komanso zachilengedwe.
3. Malinga ndi kuchuluka kwa yogwira zinthu: mlingo waukulu, pakati Mlingo wochepa komanso wochepa.

Gawoli lotsirizalo ndilosavuta kwambiri, popeza ma statin ndi omwe amapatsidwa mitundu yambiri.

Ma cholesterol achilengedwe

Kuti muchepetse mafuta m'thupi, mumapatsidwa zakudya zapadera. Ndizofunikira, monga zakudya zina zomwe zimakhala ndi zachilengedwe.

Kutsitsa cholesterol popanda mankhwala ndikotheka ndikugwiritsa ntchito:

1. Zinthu zomwe zili ndi ascorbic acid. Izi zikuphatikiza ndi zipatso za zipatso, zakuda zakuda, nyanja yamchere, m'chiuno, ndi tsabola wokoma.
2. Zogulitsa ndi nikotini acid. Izi ndi mitundu yonse ya mtedza, nyama yopendekera, nsomba yofiira.
3. Omega-3 mafuta acids - nsomba zofiira, mafuta aliwonse azamasamba.
4. Polyconazole. Imapezeka m'm nzimbe, ndipo ingagulidwe ku pharmacy.
5. Pectin. Kuzindikira kwake kwakukulu kumadziwika mu maapulo, kaloti, kabichi, nyemba, chimanga, chinangwa.
6. Resveratrol ndi mphesa.
7. Chi Turmeric

Garlic imathandizanso cholesterol yotsika.

Kodi ndiyenera kumwa ma statins ndikumatsata zakudya za anticholesterol? Zakudya zoyenera ndi gawo la mankhwalawa. Chifukwa chake, wodwalayo amasintha momwe zilili, wodwalayo amasintha zakudya ndikumwa mankhwala a gululi.

Contraindication

Choyamba, gululi la mankhwalawa limapangidwa mwa azimayi panthawi yoyembekezera. Ndipo zoletsedwa kuzigwiritsa ntchito pazinthu zotere:

• matupi awo sagwirizana, kusalolera pakapangidwe kamankhwala.
• matenda akulu a impso
• kukanika kwa endocrine system,
• matenda a musculoskeletal system,
• matenda a chiwindi osachiritsika.

Ngati mugwiritsa ntchito mankhwala a statin kwa nthawi yayitali, akhoza kuyambitsa mavuto:

• kupweteka m'matumbo am'mimba,
• kudzimbidwa
• kusanza ndi kusanza
• kupendekera
• Kutupa kwa malekezero ake kumtunda ndi m'munsi,
• kunenepa kwambiri, kunenepa kwambiri,
• minofu kukokana
• kupweteka kumbuyo
• matenda olowa.

Komanso, kuphatikiza kwa mankhwala omwe ali ndi zovuta mankhwala ayenera kukumbukiridwa. Kugwiritsa ntchito mankhwala osagwirizana ndi ma statins kungayambitse zotsatira zoyipa.

Mwachidule, dziwani kuti ma statins ndi otetezeka komanso ogwira mtima ngati atagwiritsidwa ntchito moyenera. Mukamayang'ana momwe munthu akuonekera m'thupi, zomwe zimayenderana ndi matenda, wodwalayo amasankha njira zothandiza kwambiri.