Flemoklav Solutab 875 125 mg - malangizo ogwiritsira ntchito

Flemoklav Solutab 875 + 125 mg - mankhwala ochokera pagulu la ma penicillin omwe ali ndi zochita zambiri. Kuphatikiza kophatikizira kwa amoxicillin ndi clavulanic acid, choletsa-lactamase inhibitor.

Piritsi limodzi lili:

Chosakaniza chogwira ntchito: amoxicillin trihydrate (yomwe imagwirizana ndi amoxicillin base) - 1019.8 mg (875.0 mg), potaziyamu clavulanate (yomwe imafanana ndi clavulanic acid) - 148.9 mg (125 mg).
Omwe amathandizira: cellulose omwazika - 30,4 mg, cellcrystalline cellulose - 125.9 mg, crospovidone - 64.0 mg, vanillin - 1.0 mg, kununkhira kwa tangerine - 9.0 mg, kununkhira kwa mandimu - 11.0 mg, saccharin - 13.0 mg; magnesium stearate - 6.0 mg.

Kugawa

Pafupifupi 25% ya clavulanic acid ndi 18% ya plasma amoxicillin amagwirizanitsidwa ndi mapuloteni a plasma. Kuchuluka kwa kufalitsa amoxicillin ndi 0,3 - 0,4 l / kg ndipo kuchuluka kwa magawidwe a clavulanic acid ndi 0,2 l / kg.

Pambuyo pokonzekera intravenous, amoxicillin ndi clavulanic acid amapezeka mu chikhodzodzo, m'mimba, pakhungu, mafuta ndi minofu minofu, mu madzi amwano ndi a peritoneal, komanso bile. Amoxicillin amapezeka mkaka wa m'mawere.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Biotransformation

Amoxicillin amapakidwa pang'ono limodzi ndi mkodzo mu mawonekedwe a penicilloid acid, mu 10-25% yoyamba ya mankhwala. Clavulanic acid imapangidwa mu chiwindi ndi impso (zowonjezera mu mkodzo ndi ndowe), komanso mpweya wa kaboni ndi mpweya wotayika.

Hafu ya moyo wa amoxicillin ndi clavulanic acid kuchokera ku seramu yamagazi mwa odwala omwe ali ndi vuto lofanana ndi aimpso pafupifupi ola limodzi (0,9-1.2 maola), mwa odwala omwe ali ndi chilolezo cha creatinine mkati mwa 10-30 ml / mphindi ndi maola 6, ndipo kwa anuria amasiyanasiyana. pakati pa 10 ndi 15 maola. Mankhwala amachotsedwa pa hemodialysis.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osasinthika ndi mkodzo m'maola 6 oyamba.

Zizindikiro zogwiritsidwa ntchito

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

Matenda opumira kwambiri a m'mapapo (kuphatikizapo matenda a ENT), mwachitsanzo.
Matenda ochepetsa kupuma am'mimba, monga kufalikira kwa chifuwa cham'mimba, chibayo, ndi bronchopneumonia, omwe amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus fuluwenza, ndi Moraxella catarrhalis.
Matenda a urogenital thirakiti, monga cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli), Staphylococcus saprophyticus ndi mitundu ya genus Enterococcus, komanso gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae.
Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, Streptococcus pyogene, ndi mitundu ya mtundu wa Bacteroides.
Kutupa kwa mafupa ndi mafupa, mwachitsanzo, osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, ngati pakufunika kutero, chithandizo cha nthawi yayitali ndizotheka.
Matenda a Odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, zotupa zamano kwambiri ndi kufalitsa kwa cellulitis.
Matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake, intra-m'mimba sepsis) monga gawo la njira yothandizira.

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Flemoklav Solutab ®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Flemoklav Solutab ® amasonyezedwanso zochizira matenda osakanikirana omwe amayambitsidwa ndi tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa beta-lactamase, yokhudzidwa ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Contraindication

Mankhwalawa amatha kutengedwa pokhapokha atakambilana ndi dokotala komanso kukayezetsa. Kugwiritsa ntchito mosamala mapiritsi a mankhwalawa popanda kupenda kumapangitsa chithunzi cha matenda kupangitsa kuti zikhale zovuta kudziwa bwinobwino.

Mapiritsi a Flemoklav Solutab 875 + 125 mg ali ndi zotsutsana zotsatirazi:

Hypersensitivity kwa amoxicillin, clavulanic acid, zinthu zina za mankhwalawa, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,
magawo am'mbuyomu a jaundice kapena chiwindi chovuta kugwiritsa ntchito pophatikiza amoxicillin wokhala ndi clavulanic acid m'mbiri
ana osakwana zaka 12 kapena kulemera kwa thupi zosakwana 40 makilogalamu,
aimpso kuwonongeka (creatinine chilolezo ≤ 30 ml / min).

Mosamala kwambiri, mankhwalawa pazotsatira zotsatirazi:

Kulephera kwamphamvu kwa chiwindi,
matenda am'mimba (kuphatikizapo mbiri ya colitis yokhudzana ndi kugwiritsidwa ntchito kwa penicillin),
aakulu aimpso kulephera.

Mlingo ndi makonzedwe

Poletsa zizindikiro za dyspeptic, Flemoklav Solutab ® amalembedwa koyambirira kwa chakudya. Piritsi limamezedwa lonse, kutsukidwa ndi kapu ya madzi, kapena kusungunuka ndi theka kapu yamadzi (osachepera 30 ml), kuyambitsa bwino musanagwiritse ntchito.

Zokhudza pakamwa.

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita stepwise mankhwala (woyamba kholo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Matenda aimpso

Mapiritsi a 875 + 125 mg ayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi chilolezo cha creatinine choposa 30 ml / min, kusintha mawonekedwe ake sikofunikira.

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa. Odwala omwe ali ndi vuto laimpso, amatha kukomoka.

Mimba

Mu maphunziro a ntchito yolereka mu nyama, pakamwa komanso pa uchembere wabwino wa amoxicillin + clavulanic acid sizinayambitsa zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matuza kusanachitike, anapezeka kuti mankhwala a prophylactic amatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis akhanda. Monga mankhwala onse, Flemoklav Solutab ® samalimbikitsidwa kuti agwiritse ntchito panthawi yomwe ali ndi pakati, pokhapokha ngati phindu lomwe limayembekezera kwa mayi likupereka chiwopsezo cha mwana wosabadwayo.

Nthawi yoyamwitsa

Flemoklav Solutab angagwiritsidwe ntchito poyamwitsa. Kupatula kuti kuthekera kwa kutulutsa chidwi, kutsegula m'mimba, kapena masoka a mucous nembanemba amkati omwe amalumikizana ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimagwira popanga mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zimawonedwa mwa makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Zotsatira zoyipa

Mukamamwa mapiritsi a Flemoklav Solutab odwala omwe ali ndi hypersensitivity ya mankhwala, mavuto amadzayamba:

kuchokera ku ziwalo za hemopoietic - thrombocytosis, leukopenia, kuchepa magazi, thrombocytopenia, agranulocytosis, kuchuluka kwa prothrombin nthawi,
Kuchokera mmimba - kupweteka m'mimba, nseru, kutentha kwa mtima, kusanza, kutsegula m'mimba, matenda am'mimba, matenda am'mimba, chiwindi, dysbiosis, kukula kwa chiwindi,
ku mantha amisempha - kupweteka, paresthesias, chizungulire, kusokonekera, psychomotor, kusokonezeka kwa tulo, mkwiyo,
Kuchokera kwamikodzo dongosolo - kutukusira kwa chikhodzodzo, kupweteka pokodzo, kupweteka kwapakati, kupsa ndi kuyabwa mu nyini mwa akazi,
thupi lawo siligwirizana - zotupa pakhungu, exanthema, urticaria, dermatitis, mankhwala, kutentha kwa anaphylactic, matenda a seramu,
kukula kwa umunthu wapamwamba.

Ngati vuto limodzi kapena zingapo zakula, muyenera kufunsa dokotala kuti akuthandizeni, mungafunike kusiya kumwa mankhwalawo.

Bongo

Zizindikiro zochokera m'matumbo am'mimba komanso kusokonezeka kwa madzi mu electrolyte zitha kuwonedwa. Amoxicillin crystalluria wafotokozedwa, nthawi zina zomwe zimapangitsa kuti pakhale kulephera kwa impso (onani gawo "Maupangiri Apadera ndi Mayendedwe").

Kusinthika kumatha kuchitika kwa odwala omwe ali ndi vuto la impso, komanso mwa iwo omwe amalandira kuchuluka kwa mankhwalawa (onani gawo "Mlingo ndi Administration" - Odwala omwe ali ndi vuto laimpso, "Zotsatira zoyipa").

Zizindikiro kuchokera m'mimba thirakiti ndi chizindikiro cha mankhwala, kulabadira kuthekera kwa kutulutsa bwino muyezo wamagetsi wamadzi. Amoxicillin ndi clavulanic acid amatha kuchotsedwa m'magazi ndi hemodialysis.

Zotsatira za kafukufuku woyembekezeredwa yemwe adachitika ndi ana 51 kumalo operekera poizoni adawonetsa kuti kuyang'anira amoxicillin pamlingo wochepera 250 mg / kg sizinachititse kuti pakhale ndi zidziwitso zazikulu zakuchipatala ndipo sizinafune kuti pakhale chiphuphu.

Kuchita kwa mankhwala ndi mankhwala ena

Ndi makonzedwe omwewo munthawi yomweyo mankhwala omwe ali ndi Acetylsalicylic acid kapena Indomethacin, kutalika kwa nthawi yomwe Amoxicillin amakhalabe m'magazi ndipo bile limakulirakulira, zomwe zimawonjezera chiopsezo cha mavuto.

Ndi munthawi yomweyo kugwiritsa ntchito mapiritsi a Flemoklav, solutab yokhala ndi maantacid, ma laxatives kapena aminoglycosides amachepetsa kuyamwa kwa Amoxicillin mthupi, chifukwa chamankhwala omwe amathandizira kuti mankhwalawo akhale osakwanira.

Kukonzekera kwa Ascorbic, m'malo mwake, kuonjezera kuyamwa kwa Amoxicillin m'thupi.

Ndi makonzedwe omwewo a mapiritsi a Flemoklav ndi Allopurinol, chiopsezo cha zotupa pakhungu chimakulanso.

Ndi kulumikizana kwa mankhwalawa Flemoklav Solutab ndi anticoagulants osadziwika, wodwalayo amatha kutuluka magazi.

Nthawi zina, mothandizidwa ndi mankhwalawa, kugwiritsa ntchito njira zakulera zamkamwa kumachepa, chifukwa chake, azimayi omwe amakonda mtundu wotetezedwa ku mimba yosafunikira ayenera kusamala ndikugwiritsa ntchito njira zoletsa panthawi ya mankhwalawa.

Malangizo apadera

Odwala amakonda chizolowezi chomwa mankhwala osokoneza bongo musanagwiritse ntchito Flemoklav solutab, ndikofunikira kuyesa kuyesa, chifukwa ma penicillin nthawi zambiri amayambitsa ziwengo. Ndi kukula kwa anaphylaxis kapena angioedema, mankhwalawo amathetsedwa nthawi yomweyo ndikuyang'ana kwa dokotala.

Simungasokoneze chithandizo ndi mankhwalawo mutangoyamba kusintha kumene. Ndikofunikira kumwa maphunziro okhazikitsidwa ndi adokotala mpaka kumapeto. Kulowerera mankhwala pasadakhale kungayambitse kukula kwa kukana kwa tizilombo toyambitsa matenda ku Amoxicillin komanso kusintha kwa matendawa kukhala matenda obwera chifukwa cha maphunzirowo. Sitikulimbikitsidwa kumwa mapiritsi nthawi yayitali kuposa nthawi yoikidwiratu (osaposa masabata awiri), chifukwa pamenepa chiwopsezo cha kukhala wamphamvu kwambiri komanso kuchuluka kwa zizindikiro zonse za matendawa kumachuluka. Popeza mankhwalawa amathandizira munthu asanadutse masiku atatu kuchokera pa chiyambi chamankhwala, wodwalayo ayenera kufunsa dokotala kuti afotokozere za matendawo komanso kuti akonze mankhwalawo.

Ngati kutsekula m'mimba kumachitika pakumwa mankhwalawo ndikudula ululu wam'mimba, chithandizo chiyenera kuyimitsidwa nthawi yomweyo ndipo adokotala azifunsidwa, zomwe zingayambitse matenda a pseudomembranous colitis.

Odwala omwe ali ndi matenda osachiritsika a chiwindi ayenera kusamala makamaka akamagwiritsa ntchito Flemoklav Solutab, chifukwa motsogozedwa ndi mankhwala opha maantibayotiki, momwe mbali yonse imagwirira ntchito ingathe kukulira.

Mukamamwa mankhwala osokoneza bongo, muyenera kusamala mukamayendetsa galimoto kapena zida zomwe zimafunika kuyankha mwachangu. Izi ndichifukwa choti mukamalandira chithandizo, odwala amatha kumva chizungulire mwadzidzidzi.

Mapiritsi 7 pachimake, matuza awiri pamodzi ndi malangizo ogwiritsira ntchito adayikidwa pabokosi lamatoni.

Mankhwala Okhala Pamalo a Pharmacy

Analogs a Flemoklav Solutab 875 + 125 mwa mankhwala a pharmacological ndi:

Mapiritsi a Augmentin ndi ufa woyimitsidwa
Amoxiclav
Amoxicillin
Flemoxin

M'mafakisi ku Moscow, mtengo wapakati wa mapiritsi a Flemoklav Solutab 875 + 125 mg ndi 390 rubles. (14 ma PC).

Fomu ya Mlingo:

Piritsi limodzi lili:

Chithandizo: amxicillin trihydrate (yomwe imagwirizana ndi amoxicillin base) - 1019.8 mg (875.0 mg), potaziyamu clavulanate (yomwe imafanana ndi clavulanic acid) -148.9 mg (125 mg).

Othandizira: mapiritsi omwazika - 30,4 mg, cellcrystalline cellulose - 125.9 mg, crospovidone - 64.0 mg, vanillin - 1.0 mg, kukoma kwa tangerine - 9.0 mg, kununkhira kwa mandimu - 11.0 mg, saccharin - 13, 0 mg, magnesium stearate - 6.0 mg.

Mapiritsi okhala ndi mawonekedwe obisika kuchokera oyera mpaka achikasu, popanda zoopsa, zolembedwa "425" komanso chithunzi cha kampani. Malo amtundu wa brown amaloledwa.

Mlingo

Mapiritsi okhala ndi moyo 875 mg + 125 mg

Piritsi limodzi lili

ntchito: amoxicillin mu mawonekedwe a amoxicillin trihydrate

- 875 mg, clavulanic acid mu mawonekedwe a potaziyamu clavulanate - 125 mg.

zokopa: cellers wopatsika, cellcrystalline cellulose, crospovidone, vanillin, mandarin kununkhira, mandimu kununkhira, saccharin, magnesium stearate.

Mapiritsi okhala ndi zoyera kuchokera ku zoyera mpaka zachikasu, zosowa, zolembedwa "GBR 425" ndi chithunzi cha logo. Malo amtundu wa brown amaloledwa

Mankhwala

Pharmacokinetics

Mtheradi wa bioavailability wa amoxicillin / clavulanic acid ndi 70%. Mafuta osungirako zakudya popanda kudya. Pambuyo pa limodzi mlingo wa Flemoklav Solutab pa mlingo wa 875 + 125 mg, kuchuluka kwambiri kwa amoxicillin m'madzi a m'magazi kumapangidwa pambuyo pa ola limodzi, ndipo ndi 12 μg / ml. Kumanga mapuloteni a Serum kuli pafupifupi 17-20%. Amoxicillin amadutsa chotchinga ndi kudutsa mkaka wa m'mawere ochepa.

Chilolezo chonse cha zinthu ziwiri zogwira ntchito ndi 25 l / h.

Pambuyo pokonzekera intravenous, amoxicillin ndi clavulanic acid amapezeka mu ndulu ya ndulu, m'mimba, pakhungu, mafuta ndi minofu minofu, mu madzi amwano ndi a peritoneal, komanso mu bile. Amoxicillin amapezeka mkaka wa m'mawere.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Amoxicillin amapukusidwa pang'ono pamodzi ndi mkodzo mu mawonekedwe a penicilloid acid, mu 10-25% yoyamba ya mankhwala. Clavulanic acid imapangidwa mu chiwindi ndi impso (zowonjezera mu mkodzo ndi ndowe), komanso mpweya wa kaboni ndi mpweya wotayika.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osasinthika ndi mkodzo m'maola 6 oyamba.

Mankhwala

Flemoklav Solutab® - anti-spectrum antiotic, kuphatikiza kwa amoxicillin ndi clavulanic acid - beta-lactamase inhibitor. Imagwira bactericidal, imalepheretsa kapangidwe ka khoma la bakiteriya. Imagwira ntchito motsutsana ndi gramu-gramu komanso gram-hasi opanda pake (kuphatikiza zingwe zopanga beta-lactamases). Clavulanic acid omwe ali m'gulu lamankhwala osokoneza bongo a II, III, IV ndi V a beta-lactamase, osagwira ntchito motsutsana ndi mtundu I beta-lactamases opangidwa Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid imakhala yotentha kwambiri chifukwa cha penicillinases, chifukwa imapanga zovuta ndi enzyme, yomwe imalepheretsa kuchepa kwa enzymatic pansi pa mphamvu ya beta-lactamases ndikukulitsa mawonekedwe ake ochita.

Flemoklav Solutab® Imagwira:

Mabakiteriya olimbitsa thupi aerobic: Streptococcus pyogene, viridans wa Streptococcus, Streptococcus pneumoniae, Staphylococcus aureus (kuphatikiza zingwe zopanga beta-lactamases), Staphylococcus epidermidis (kuphatikiza zingwe zopanga beta-lactamases), Enterococcus faecalis, Corynebacterium spp. Bacillus anthracis, Listeria monocytogenes,Gardnerellavaginalis

Bakiteriya wa gramu yabwino wa Anaerobic: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.

Mabakiteriya olakwika a aerobic: Escherichia coli, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Yersinia enterocolitica, Salmonella spp., Shigella spp., Haemophilus influenzae, Haemophilus duсreyi, Neisseria gonorrhoeae (kuphatikiza tizilombo ta mabakiteriya pamwambapa omwe amapanga beta-lactamases), Neisseria meningitidis, Bordetella pertussis, Gardnerella vaginalis, Brucella spp., Branhamella catarrhalis, Pasteurella multocida, Campylobacter jejuni, Vibrio cholerae, Moraxella catarrhalis, Helicobacter pylori.

Mabakiteriya osokoneza bongo a Anaerobic: Bacteroides spp.kuphatikiza Bacteroides fragilis,Fusobacteriumspp (kuphatikiza zingwe zopanga beta-lactamases).

Mlingo ndi makonzedwe

Kutalika kwa chithandizo kumatengera kuopsa kwa matendawa ndipo sikuyenera kupitirira masiku 14 popanda vuto linalake.

Akuluakulu ndi ana ≥ 40 kg Flemoklav Solyutab ® mu kipimo

875 mg / 125 mg ndi mankhwala 2 kawiri pa tsiku.

Ndi matenda am'munsi kupuma thirakiti kapena otitis media, kumwa mankhwala akhoza kuchuluka mpaka katatu patsiku.

Mlingo umodzi umatengedwa pafupipafupi, pafupifupi maola 12 aliwonse.

Kuyambira 25 mg / 3.6 mg / kg / tsiku mpaka 45 mg / 6.4 mg / kg / tsiku kawiri pa tsiku.

Pa matenda am'munsi kupuma thirakiti kapena otitis media, mlingo akhoza kuchuluka kwa 70 mg / 10 mg / kg / tsiku, 2 kawiri pa tsiku.

At odwala ndi mkhutu aimpso ntchito excretion wa clavulanic acid ndi amoxicillin kudzera impso amachepetsa. Flemoklav Solutab ® pa mlingo wa 875 mg / 125 mg ungagwiritsidwe ntchito pokhapokha posintha fayidi> 30 ml / min.

At Odwala omwe ali ndi vuto la chiwindi Flemoklav Solyutab ® ayenera kusankhidwa mosamala. Ntchito ya chiwindi iyenera kuyang'aniridwa nthawi zonse.