Glucophage XR

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Glucophage. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito glucophage pamachitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Glucophage analogues kukhalapo kwa masanjidwe omwe amapezeka. Gwiritsani ntchito mankhwalawa mtundu wa shuga wachiwiri mwa akulu, ana, komanso panthawi yoyembekezera. The zikuchokera ndi mogwirizana ndi mankhwala ndi mowa.

Glucophage - mankhwala akumwa a hypoglycemic ochokera pagulu la Biguanide.

Glucophage imachepetsa hyperglycemia, popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi.

Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis. Kuchepetsa mayamwidwe m'matumbo.

Metformin (yogwira mankhwala a Glucophage) imalimbikitsa kapangidwe ka glycogen, zomwe zimakhudza synthetase ya glycogen. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Kuphatikiza apo, ili ndi phindu pa metabolidi ya lipid: imatsitsa cholesterol yathunthu, LDL ndi TG.

Poyerekeza ndi kumbuyo kwa kutenga Glucofage, kulemera kwa thupi la wodwalayo mwina kumakhala kosasunthika kapena kumachepetsedwa pang'ono.

Kupanga

Metformin hydrochloride + Excipients.

Pharmacokinetics

Mutatha kumwa mankhwalawo mkati, Glucophage amachokera kwathunthu m'mimba. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Mtheradi bioavailability ndi 50-60%. Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma. Amachepetsa pang'ono ndi kupukusidwa ndi impso.

Zizindikiro

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:

• Akuluakulu, monga monotherapy kapena kuphatikiza mankhwala ena amkamwa hypoglycemic, kapena insulin,
• mwa ana a zaka 10 kapena kupitirira ngati monotherapy kapena osakaniza.

Kutulutsa Mafomu

Mapiritsi okhala ndi 500 mg, 850 mg ndi 1000 mg.

Mapiritsi olimbitsa thupi a 500 mg ndi 750 mg (Kutalika).

Malangizo ogwiritsira ntchito ndi regimen

Mankhwala amatengedwa pakamwa.

Monotherapy ndi kuphatikiza mankhwalawa ndi ena othandizira pakamwa

Mulingo woyambira woyamba ndi 500 mg kapena 850 mg katatu patsiku mutatha kudya kapena pakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg patsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba kwambiri ndi 3000 mg patsiku, wogawidwa pawiri.

Kuchepetsa pang'ono kwa mankhwalawa kungathandize kusintha kulolerana kwa m'mimba.

Odwala kulandira metformin mu Mlingo wa 2-3 g patsiku angathe kusamutsidwa ku makonzedwe a mankhwala Glucofage 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg patsiku, womwe umagawidwa pazigawo zitatu.

Pankhani yakukonzekera kusintha kwa kutenga mankhwala enanso a hypoglycemic: muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucophage pamwambapa wonenedwa pamwambapa.

Kuphatikiza kwa insulin

Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Glucophage ndi 500 mg kapena 850 mg kawiri pa tsiku, pomwe mlingo wa insulin umasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ana ndi achinyamata

Mwa ana a zaka zapakati pa 10 ndi kupitirira, Glucophage ingagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi patsiku mutatha kudya kapena. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba

Chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa zomwe zili serum creatinine osachepera 2-4 pachaka).

Glucophage iyenera kumwedwa tsiku lililonse, popanda kusokonezedwa. Ngati chithandizo chalekeka, wodwalayo ayenera kudziwitsa dokotala.

Mankhwala amatengedwa pakamwa. Mapiritsiwo amamezedwa kwathunthu popanda kutafuna, kutsukidwa ndi madzi pang'ono.

500 mg mapiritsi otulutsidwa

Mankhwalawa amatengedwa nthawi ya chakudya chamadzulo (nthawi 1 patsiku) kapena pakudya cham'mawa komanso chakudya chamadzulo (2 kawiri pa tsiku). Mapiritsi ayenera kumwedwa kokha ndi chakudya.

Mlingo wa mankhwala umatsimikizika potengera zomwe zili m'magazi a m'magazi.

Monotherapy ndi kuphatikiza mankhwalawa kuphatikiza othandizira ena a hypoglycemic

Mankhwala Glucofage Long amatchulidwa koyamba mlingo wa 500 mg (piritsi 1) 1 nthawi patsiku chakudya.

Mukasintha kuchokera ku Glucofage (mapiritsi okhala ndi kutulutsidwa kwanthumbo kantchito), gawo loyambirira la Glucofage Long liyenera kukhala lofanana ndi tsiku la Glucofage.

Mlingo kukhudzana: kutengera glucose zomwe zili m'magazi, tsiku lililonse la 10-15 pang'onopang'ono mlingo umakulitsidwa ndi 500 mg mpaka pazipita tsiku lililonse.

Mulingo wambiri tsiku ndi tsiku wa Glucofage Long ndi 2 g (mapiritsi 4) nthawi imodzi patsiku lamadzulo.

Ngati magazi a glucose sangakwaniritsidwe kamodzi pazomwe zimachitika kamodzi patsiku, ndiye kuti mutha kulingalira zogawa mankhwalawa kangapo patsiku malinga ndi dongosolo lotsatirali: mapiritsi awiri pakudya cham'mawa komanso mapiritsi awiri panthawi ya chakudya.

Mukamagwiritsa ntchito mankhwala Glucofage Long pamodzi ndi insulin, muyezo woyenera wa mankhwalawa ndi 500 mg (piritsi 1) kamodzi patsiku, ndipo mlingo wa insulin umasankhidwa potengera zotsatira za kuyeza shuga m'magazi a m'magazi.

Glucophage Kutalika kuyenera kumwedwa tsiku lililonse, popanda kusokonezedwa. Ngati chithandizo chalekeka, wodwalayo ayenera kudziwitsa dokotala.

Mukadumpha mlingo wotsatira, mlingo wotsatira uyenera kumwedwa nthawi yokhazikika. Musamachulukitse kawiri pa mankhwala.

Mapiritsi ochita kuleza 750 mg

Mankhwalawa amatengedwa nthawi ya chakudya chamadzulo kapena pambuyo pake (1 nthawi patsiku).

Monotherapy ndi kuphatikiza mankhwalawa kuphatikiza othandizira ena a hypoglycemic

Mlingo woyamba nthawi zambiri piritsi limodzi 1 nthawi patsiku.

Pambuyo masiku 10-15 chithandizo, mlingo uyenera kusintha malinga ndi zotsatira za kuyeza magazi ndende. Kukula pang'onopang'ono kwa mankhwalawa kumathandizira kuchepetsa zoyipa kuchokera m'mimba.

Mlingo woyenera wa mankhwalawa ndi 1.5 g (mapiritsi awiri) 1 nthawi patsiku. Ngati mukulephera kukwaniritsa chiwonetsero chokwanira cha glycemic mukamamwa mlingo womwe umalimbikitsidwa, mutha kuwonjezera mankhwalawa mpaka 2.25 g (mapiritsi atatu) kamodzi patsiku.

Ngati glycemic yokwanira siyikwaniritsidwa mukamamwa mapiritsi atatu a 750 mg kamodzi patsiku, ndiye kuti mungathe kusinthira kukonzekera kwa metformin ndikumasulidwa kwazomwe zimachitika ndi 3 mg.

Kwa odwala omwe amalandila chithandizo ndi mapiritsi a metformin, muyezo wa Glucofage Long uyenera kukhala wofanana ndi mlingo wa mapiritsi a tsiku ndi tsiku ndikamasulidwa mwachizolowezi. Odwala omwe amatenga metformin mu mawonekedwe a mapiritsi omwe amapezeka mwachindunji mu 2 ga osavomerezeka amasinthidwa kupita ku Glucofage Long.

Pofuna kukonza kusintha kuchokera kwa wothandizila wina wa hypoglycemic: ndikofunikira kusiya kumwa mankhwala ena ndikuyamba kumwa Glucofage Long pa mlingo womwe ukunenedwa pamwambapa.

Kuphatikiza kwa insulin

Kuti mupeze kuwongolera kwakukhazikika kwa shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Glucofage Long ndi piritsi limodzi 750 mg 1 nthawi patsiku chakudya chamadzulo, pamene mlingo wa insulin umasankhidwa potengera zotsatira za kuyeza shuga.

Magulu apadera a odwala

Mu okalamba odwala ndi odwala aimpso kuchepetsedwa, mlingo umasinthidwa malinga ndi kuwunika kwa aimpso, omwe amayenera kuchitidwa pafupipafupi 2 pachaka.

Glucofage Long sayenera kugwiritsidwa ntchito mwa ana ndi achinyamata ochepera zaka 18 chifukwa chosowa deta pakugwiritsa ntchito.

Zotsatira zoyipa

• lactic acidosis
• pogwiritsa ntchito nthawi yayitali, kuchepa kwa mayamwidwe a vitamini B12 ndikotheka,
• kulakwira
• kusanza, kusanza,
• kutsegula m'mimba
• kupweteka m'mimba
• kusowa kwa chakudya
• erythema
• kuyabwa
• zotupa
• kuphwanya zizindikiro za chiwindi,
• chiwindi.

Pambuyo pakutha kwa Metformin, zovuta zoyipa zimatheratu.

Contraindication

• matenda ashuga ketoacidosis,
• matenda a shuga
• wodwala matenda ashuga
• kuwonongeka kwaimpso ntchito (QC

Gulu la mankhwala.

Khodi ya PBX. Oral hypoglycemic wothandizira, kupatula insulin. Nambala yosinthira mafoni ya A10V A02.

Type 2 matenda a shuga a mellitus (osadalira insulini) mwa akulu omwe ali ndi vuto la kudya komanso kuchita masewera olimbitsa thupi (makamaka odwala omwe ali ndi kunenepa kwambiri), monga monotherapy kapena kuphatikiza ena othandizira pakamwa kapena molumikizana ndi insulin.

Contraindication

• Hypersensitivity kuti metformin kapena mbali ina iliyonse ya mankhwala
• matenda ashuga ketoacidosis, matenda ashuga,
• mkhutu aimpso ntchito (creatinine chilolezo
• zovuta pachimake ndi chiopsezo cha aimpso kukanika, monga:

kuperewera kwa madzi m'thupi, matenda opatsirana opatsirana, mantha

• matenda owopsa komanso osachiritsika omwe angayambitse kukula kwa hypoxia:

kugunda kwa mtima kapena kupuma, chithokomiro chachikulu cha myocardial, kugwedezeka

• chiwindi ntchito, poizoni mowa, uchidakwa.

Mlingo ndi makonzedwe

Monotherapy kapena kuphatikiza mankhwalawa molumikizana ndi ena othandizira pakamwa.

Mankhwala GlucofageXR1000 mg amagwiritsidwa ntchito kamodzi patsiku ndi chakudya madzulo. Mulingo wofunikira kwambiri ndi mapiritsi awiri patsiku.

Odwala omwe amathandizidwa ndi Glucofage XR, kuchuluka kwa 2000 mg patsiku sikuyenera kupitilira.

Kwa odwala omwe ayamba kulandira chithandizo, nthawi zambiri mlingo woyambirira wa Glucophage XR ndi 500 mg kamodzi tsiku lililonse panthawi yamadzulo.

Ngati kuchuluka kwa glycemia sikungatheke ndi Glucofage XR muyezo waukulu wa 2000 mg, womwe umatengedwa kamodzi patsiku, mlingo ungagawidwe pawiri (kamodzi m'mawa komanso kamodzi madzulo, pakudya). Ngati kuchuluka kwa glycemia sikungakhale kosatheka, mutha kuumitsa Glucofage, mapiritsi okhala ndi mafilimu, 500 mg, 850 mg, 1000 mg pa mlingo woyenera wa 3000 mg patsiku.

Pankhani yosinthira ku mankhwala a GlucofageXR, mapiritsi otulutsidwa, 1000 mg, ndikofunikira kusiya kumwa mankhwala ena a antiidiabetes.

Musanagwiritse ntchito mankhwala Glucofage XR 1000 mg, mlingo umatengedwa ndipo umayamba ndi makonzedwe a Glucofage XR 500 mg.

GlucofageXR1000 mg imagwiritsidwa ntchito ngati chithandizo chokonzanso odwala omwe adalandira kale chithandizo cha metformin. Mlingo wa GlucofageXR, mapiritsi olimbikitsidwa otulutsidwa ayenera kukhala ofanana ndi tsiku lililonse la mapiritsi otulutsidwa mwachangu.

Kuphatikiza mankhwala ndi insulin .

Kuti akwaniritse bwino kuchuluka kwa shuga m'magazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala osakanikirana. Mwachilengedwe, mlingo woyambirira wa Glucofage XR ndi 500 mg kamodzi patsiku ndi chakudya madzulo, ndiye kuti mlingo wa insulin umasankhidwa malinga ndi zotsatira za kuyeza shuga m'magazi.

Glucophage XR, mapiritsi osinthika osasunthika, 1000 mg angagwiritsidwe ntchito pambuyo poti aperekedwe ka mankhwala.

Odwala okalamba kuwonongeka kwa impso, motero, mlingo wa metformin uyenera kusankhidwa potengera ntchito ya aimpso, yoyenera kuchitika pafupipafupi (onani Gawo " Zolemba ntchito »).

Zotsatira zoyipa

Nthawi zambiri zoyipa zimachitika, makamaka kumayambiriro kwa mankhwalawa, enudot, kusanza, kutsekula m'mimba, kupweteka kwam'mimba, kusowa kudya.

Zotsatira zoyipa zomwe zimachitika pafupipafupi zimagawidwa m'magulu otsatirawa:

nthawi zambiri ( > 1/10), nthawi zambiri ( > 1/100 ndi 1/1000 ndi 1/10000 ndi 400 ml / min, izi zikuwonetsa kuti metformin imachotsedwera chifukwa chosinthana ndi kusefukira kwam'mimba komanso kubisalira kwa tubular. Mutamwa, theka-moyo ndi pafupifupi maola 6.5. Mu vuto la impso, kutsekeka kwa impso kumatsika molingana ndi kupezeka kwa creatinine chilolezo, motero kuthetsa theka la moyo kumawonjezeka, komwe kumabweretsa kuwonjezeka kwa plasma metformin.

Ndi mankhwala ati omwe amagwiritsidwa ntchito pochiritsa matenda?

Type 2 shuga mellitus ndi endocrine matenda omwe maselo amthupi amakana insulini yopangidwa ndi kapamba.

Zotsatira zake, maselo amalephera kumva kukoma kwa timadzi tam'magazi, glucose sangathe kulowa mu minofu, kudzikundikira m'thupi.

Nawonso, kuwonjezeka kwamankhwala a insulin kumawonekeranso, chifukwa kapamba amayamba kupanga kuchuluka kwa timadzi timeneti.

Mpaka pano, chithandizo cha matenda a shuga 2 ndi kugwiritsa ntchito imodzi mwa magulu otsatirawa a zida zamankhwala:

1. Mankhwala omwe amachokera ku sulfonylurea. The pharmacological tingati kulimbikitsa katulutsidwe wa amkati insulin. Ubwino waukulu wa gulu la mankhwalawa ndi kulekerera mosavuta kwa mankhwalawa kwa odwala ambiri.
2. Zogulitsa kuchokera ku gulu la Biguanide. Zotsatira zawo cholinga chake ndikuchepetsa kufunika kwa insulin katulutsidwe.
3. Mankhwala omwe amachokera ku thiazolidinol amathandizira kuchepetsa shuga m'magazi ndipo amathandizanso kusintha kwa mawonekedwe a lipid.
4. Amayamwa.

Maziko a mankhwala onse ochokera ku gulu la Biguanide ndiwothandizika ngati metformin. Type 2 shuga mellitus nthawi zambiri amawonetsedwa molumikizana ndi insulin - kulephera kwa maselo kuzindikira bwino mahomoni opangidwa ndi kapamba.

Zotsatira zazikulu zamankhwala zomwe mankhwala ochokera ku gulu la Biguanide ndi:

• bwino kuchepetsa shuga
• Malangizo a insulin ndi kapamba, omwe amalola kuti achepetse kuchuluka kwa thupi mthupi,
• sizimathandizira pakukula kwa hypoglycemia.

Kuphatikiza apo, mankhwala osokoneza bongo, pamodzi ndi chithandizo choyenera cha zakudya, amatha kuchepa thupi komanso kuthana ndi kunenepa kwambiri, zomwe ndizofunikira kwambiri kwa odwala omwe ali ndi vutoli.

Metformin amagwiritsidwa ntchito pochiza matenda osokoneza bongo chifukwa chowonjezera insulin. Imachepetsa kuyamwa kwa glucose m'matumbo ang'onoang'ono ndikuchepetsa mphamvu yake yopanga maselo a chiwindi.

Kuchuluka kwa Mlingo wa mankhwalawa kutengera mlingo wake.Mpaka pano, mapiritsi oterewa akupezeka ndi 400, 500, 850 kapena 100 mg ya mankhwala othandizira piritsi limodzi.

Ndi mankhwala ati a gululi omwe amaperekedwa pamsika wamankhwala? Choyambirira, mankhwalawa akuphatikiza othandizira pakamwa awa:

Kuphatikizidwa kwa mankhwalawa kuli ndi chinthu chachikulu chomwe chimagwira - metformin, yomwe imatha kuperekedwa mosiyanasiyana ndipo, mwanjira ina, imakhala ndi zotsatira zina. Mankhwala oterewa amaperekedwa m'mafakitala amzindawo kokha ndi mankhwala.

Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa

Glucophage ndi mankhwala omwe nthawi zambiri amaperekedwa kwa odwala omwe ali ndi matenda a shuga.

Mapiritsi amathandizira kuchepetsa shuga wamagazi, komanso amathandizanso kuchepetsa kunenepa kwambiri.

Mankhwalawa amagwiritsidwa ntchito ngati wodwalayo ali ndi zisonyezo zina zoti agwiritse ntchito.

Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa ndi:

• osagwirizana ndi insulin omwe amadalira odwala matenda a shuga monga chithandizo chachikulu kapena njira yonse yochizira,
• muubwana (pambuyo zaka khumi).

Chithandizo cha mankhwala chimaperekedwa ndi adotolo atatha kudya komanso kuchita masewera olimbitsa thupi osaneneka.

Kuphatikiza apo, zopindulitsa za mapiritsi a Glucophage ndi izi:

1. Imathandizira kuteteza ubongo ku ukalamba, womwe umalola kuti uzigwiritsira ntchito prophylactic zolinga motsutsana ndi matenda a Alzheimer's.
2. Mosangalatsa zimakhudza mitsempha yamagazi ndi mitsempha. Chifukwa chake, mothandizidwa ndi Metformin, kukula kwa mitsempha ya mitsempha, kulephera kwa mtima, matenda oopsa, komanso kupimitsa mtima kwamitsempha.
3. Amachepetsa mwayi wokhala ndi khansa.
4. Amathandizira kusintha kwa potency mwa abambo, omwe anali opuwala chifukwa cha matenda osiyanasiyana a senile.
5. Zimalepheretsa kukula kwa mafupa a anthu odwala matenda ashuga. Makamaka, nthawi zambiri, azimayi amakhala ndi vuto la mafupa osaneneka atasiya kusamba, popeza pali kuchepa kwakukulu kwamahomoni - estrogen.
6. Zokhudza bwino chithokomiro cha chithokomiro.
7. Ili ndi ntchito yoteteza mokhudzana ndi dongosolo la kupuma.

Kusiyana kwakukulu pakati pa Glucophage ndikuwonetsera zazotsatira monga:

• pali njira yogwirira ntchito komanso kuwonjezereka kwa mafuta m'thupi,
• chakudya chamagulu omwe amalowa mthupi limodzi ndi chakudya amalowa m'makoma am'mimba kwambiri,
• pali kukondoweza ndi kutsegula kwa glucose kukonzedwa ndi minofu minofu,
• kuchuluka kwa cholesterol yoyipa m'thupi yafupika,
• chifukwa cha zonse zomwe tafotokozazi, kunenepa kwambiri kumachoka pang'onopang'ono.

Ichi ndichifukwa chake Glucophage nthawi zambiri imagwiritsidwa ntchito ndi anthu odwala matenda ashuga, makamaka ngakhale kutsatira kwambiri chithandizo chamankhwala sikubweretsa zotsatira zoyenera.

Pharmacological katundu wa mankhwala

Chofunikira chachikulu cha mankhwala Glucofage xp ndi metformin hydrochloride; silicon dioxide, povidone, magnesium stearate, ndi macrogol amagwiritsidwa ntchito ngati zida zothandizira.

Metformin ndi chinthu chochokera ku gulu la Biguanides ndi kuchepetsa shuga.

Dziwani kuti kukonzekera kwa piritsi kumathandizira kukula kwa shuga m'magazi am'magazi, komanso kuwongolera kudumpha kwa shuga mukatha kudya.

Kugwiritsa ntchito bwino kwa mankhwalawa ndikuwonetsa zinthu zitatu zomwe zimagwira ntchito:

1. Zimathandizira kuchepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis.
2. Zimawonjezera chidwi cha maselo ndi minyewa kupita ku insulin ya mahomoni, yomwe imakhudza bwino kugwidwa ndi kupukusa kwa shuga m'magazi.
3. Imachepetsa mayamwidwe a shuga m'matumbo.

Mutatha kumwa mapiritsiwo, gawo lalikulu lomwe limagwira ntchito limagawilidwa pazinthu zina zathupi, pomwe silikugwirizana ndi mapuloteni amwazi.

Monga zikuwonetsedwa ndi malangizo a Glucofage xp 500, mankhwalawa amachotsedwa m'thupi osasinthika.

Ubwino waukulu wa chida chachipatala chotere ndikuti kumwa mankhwalawa sikuti kumayambitsa chitukuko cha hypoglycemia, monga zimakhalira nthawi zambiri ndi zotumphukira za sulfonylurea.

Malangizo ogwiritsira ntchito mankhwalawa

Njira yoyendetsera, kuchuluka ndi kuchuluka kwa mankhwalawa ndiudokotala.

Mlingo umadalira kuuma kwa matenda, m'badwo wa wodwalayo ndi chithunzi chake chonse chachipatala.

Tiyenera kudziwa kuti masiku ano pali mitundu ingapo ya mankhwalawa, yomwe imasiyana malinga ndi kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito:

Mitundu yotsatirayi yamankhwala ilipo:

• Glucophage xr 500 (imakhala ndi mazana asanu mg a yogwira ntchito)
• Glucophage xr 850,
• Glucophage xr 1000.

Mankhwala okhala piritsi amayenera kugwiritsidwa ntchito ngati mankhwala odziyimira pawokha kapena molumikizana ndi mankhwala ena ochepetsa shuga, kutengera malangizo a dokotala.

Kuyambitsa njira yothandizira mankhwalawa ndi Glucofage xr, mlingo woyambirira umakhazikitsidwa pa 500 mg ya mankhwala othandizira. Mankhwalawa amatengedwa madzulo atatha kudya. Pakatha masiku khumi mpaka khumi ndi anayi, mlingo woyambirira umatha kusintha ngati pakufunika kutero, kutengera zotsatira za kuyezetsa magazi. Ndiwonjezereka pang'onopang'ono komanso pang'ono pang'onopang'ono pamankhwala omwe amachepetsa chiopsezo chodana ndi zovuta. Mlingo woyenera kwambiri ndikutenga mapiritsi anayi patsiku, ndiye kuti, osaposa mamililita 3,000 a chinthucho. Ndikulimbikitsidwa kuti mukulitse mlingo kuti musatengedwe kamodzi pa sabata ndi mamiligalamu mazana asanu.

Kuphatikiza apo, nthawi zina, adotolo angalimbikitse kumwa mankhwalawa kawiri patsiku - m'mawa ndi madzulo. Poterepa, chizolowezi cha tsiku ndi tsiku chimagawidwa kawiri.

Nthawi zina, pofuna kukwaniritsa zotsatira zabwino, mapiritsi a Glucofage amayikidwa limodzi ndi insulin. Kuphatikizikako kumakupatsani mwayi wowongolera kuchuluka kwa shuga m'magazi.

Kuwonetsa pamachitidwe ati omwe amayenera kusamala nawo?

Kugwiritsa ntchito molakwika mankhwalawa kapena kulephera kutsatira malangizo omwe atengedwa kungayambitse zovuta.

Pankhani ya mankhwala osokoneza bongo, wodwala amayenera kugonekedwa m'chipatala nthawi yomweyo kuti athandizidwe. Monga lamulo, mankhwala othandizira amachitidwa. Kuchotsa mankhwalawo mwachangu mthupi, chinthu monga hemodiliasis chimagwiritsidwa ntchito.

Zotsatira zoyipa zomwe zitha kuchitika panthawi ya achire ndi mankhwalawa zimawonekera ngati:

1. Kukhazikitsidwa kwa chithandizo kumayambitsa limodzi ndi kuwonetsa nseru, nthawi zina ndi kusanza. Wodwalayo amatha kudandaula za kulawa kwazitsulo pamlomo wamkamwa, kupweteka pamimba, kuchuluka kwaulemu, kutsekula m'mimba komanso kusowa kwa chakudya.
2. Pogwiritsa ntchito mankhwalawa kwa nthawi yayitali, acidosis imayamba, popeza kuchepa kwa kuchuluka kwa mavitamini a B mu seramu yamagazi. Poterepa, adotolo apanga chisankho chokhudza kuchotsedwa kwa mankhwalawa.
3. chiwindi ntchito ndi hepatitis mankhwala.
4. Mwina kuwoneka ngati totupa kapena kuyabwa pakhungu, kakulidwe ka urticaria, matenda a shuga.

Akaphatikizidwa ndi mankhwala ena, odwala ayenera kusamala makamaka, popeza chiwopsezo cha zotsatira zoyipa ndi thanzi labwino zimawonjezeka. Ichi ndichifukwa chake adotolo omwe amayenera kuphunzitsidwa ayenera kudziwitsidwa za matenda onse okhudzana, komanso kumwa mankhwala ena. Kukhazikitsa pamodzi kwa Glucofage xr ndi okodzetsa zambiri kumayambitsa lactic acidosis.

Kutenga Glucofage xr ndi chlorpromazine nthawi yomweyo, pali kuwonjezeka kwambiri kwa shuga m'magazi ndipo kutulutsidwa kwa insulin ya m'madzi kumachepa.

Kodi pali zoletsa zoletsa kugwiritsa ntchito mankhwalawa?

Glucophage xr, yomwe imaphatikizapo mainformin yogwira pophika, sigwirizana ndi kumwa nthawi yomweyo.

Kuphatikiza apo, lero pali zoletsa zina pa kugwiritsa ntchito mapiritsi oterewa, omwe muyenera kudziwa.

Chachikulu contraindication kugwiritsa ntchito mankhwala:

1. Pamaso pa kuwonjezeka kwa kumverera kwa chinthu chimodzi kapena zingapo zomwe zimapanga mankhwala.
2. Mkhalidwe wa matenda a shuga a ketoacidosis kapena kholo la odwala matenda ashuga amawonekera.
3. Zowonongeka zamkati zimawonedwa. Matendawa akuwonetsa zotsatira za clearine zotsika kuposa 60 ml / min.
4. Matenda opatsirana kwambiri.
5. Kuthetsa madzi m'thupi
6. Kukula kwa ma pathologies mu mitundu yovuta kapena yovuta yomwe ingayambitse minofu hypoxia.
7. Lactic acidosis.
8. Matenda akulu a chiwindi.
9. Iwo ali osavomerezeka kugwiritsa ntchito mankhwalawa pa nthawi yoyembekezera komanso mkaka wa m`mawere.
10. Muubwana, mpaka zaka khumi.

Popewa chiopsezo chokhala ndi vuto la chikomokere cha hyperglycemic, mankhwalawa saloledwa kutengedwa nthawi yomweyo ndi danazol.

Katswiri muvidiyoyi munkhaniyi afotokoza mwatsatanetsatane za Hypoglycemic zotsatira za Glucofage.