Kukonza kosagwiritsa ntchito mankhwala osokoneza bongo

Glidiab ndi mankhwala osokoneza bongo a hypoglycemic, omwe amatanthauza m'badwo wachiwiri wa sulfonylurea. Ndikulimbikitsidwa zochizira mtundu wachiwiri wa matenda a shuga limodzi ndi zakudya zopatsa thanzi komanso zolimbitsa thupi.

Mankhwala amathandizira kuchepetsa shuga la magazi ndikuwakhazikika pamlingo womwe mukufuna. Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kumawonjezera mphamvu ya zakudya zomwe munthu akudwala matenda ashuga kwambiri kapena onenepa kwambiri.

Mutha kugula mankhwala ku khemisi kapena ku pharmacy kiosk. Mtengo wa mankhwalawa umasiyana ndi ma ruble 130 mpaka 200, ndipo zimatengera kuchuluka kwa zinthu zogwiritsidwa ntchito pamapiritsi. Glidiab 80 ndi 30 mg akugulitsa.

M'pofunika kuganizira zomwe contraindication ndi zotsatira zoyipa zomwe mankhwalawo ali nazo, komanso momwe angathere molondola? Ndi ndemanga iti ku Glidiab, ndipo anthu ashuga akuti chiyani?

Mfundo za mankhwalawa

Mankhwala ochiza matenda "okoma" a mtundu wachiwiri amapezeka mu mawonekedwe apiritsi, chinthu chachikulu chomwe chimagwiritsidwa ntchito pa mankhwala ndi glyclazide. Kuphatikizika kwa mapiritsiwa kumaphatikizanso zina zowonjezera - microcrystalline cellulose, magnesium stearate ndi zinthu zina.

Chidule "MV", chopezeka m'dzina la mankhwalawa, chikuyimira kumasulidwa. Ma Dokotala akuwunikira kuti izi zimakuthandizani kuti mumwe mankhwalawa kamodzi patsiku.

Chopanga chachikulu panthawi ya mayamwidwe amathandizira kulimbikitsa ntchito ya minofu ya glycogen synthetase komanso kupanga kwa insulin ya thupi m'thupi. Kuphatikiza apo, gawo lalikulu limasankha chinsinsi cha insulini, ndipo zimapangitsa kuti azikhala ndi chidwi chambiri.

Chosafunikanso kwambiri ndichakuti mapiritsi a Glidiab amathandizira kuchepetsa pakati pa kugwiritsa ntchito chakudya ndi kuyamba kwa insulin. Kudziwitsa za mankhwalawa kukuwonetsa kuti kugwiritsidwa ntchito kwa mankhwalawa kumatsitsa chidwi cha dziko la hyperglycemic, pomwe pakubwezeretsanso pachimake cha kupangika kwa mahomoni.

Zinthu zonsezi pamwambapa zimakhudza kagayidwe kazakudya ndi michere. Kugwiritsa ntchito mankhwala Glidiab kumachepetsa mwayi wokhala ndi kusintha kwa mitsempha ya mitsempha m'mitsempha yamagazi.

Chifukwa cha zodabwitsa za mawonekedwe, mlingo umodzi patsiku umatsimikizira wodwala kuti azigwira ntchito ya plasma kwa maola 24.

Contraindication ndi zoyipa

Pa Glidiab MV, malangizo ogwiritsidwira ntchito akuti mankhwalawo ali ndi mndandanda womveka bwino wa zotsutsana zomwe zimapangitsa kuti mankhwalawa asagwiritsidwe ntchito m'njira zina.

Simungathe kumwa mapiritsi othandizira matenda a matenda a shuga 1 a mtundu 1

Kuphatikiza apo, Glidiab MB imatsutsana pazochitika izi: kusalolera kwa mankhwala athunthu kapena zida zake, kuvulala kwambiri, kulowererapo kwa opaleshoni, chiwindi ndi impso ntchito, nthawi ya bere ndi nthawi yoyamwitsa.

Mankhwala a Glidiab amatha kupangitsa zotsatirazi zoyipa za thupi:

• Kusokonezeka mu mtima ndi kuzungulira kwa dongosolo: leukopenia, kuchepa magazi.
• Hypoglycemic state (kuchepa kwambiri kwa shuga m'magazi), kuchuluka kudya, kufooka, kuperewera, kusilira, thukuta, kupweteka mutu ndi chizungulire.
• Kukhumudwa kwachisoni, kusakwiya mosavomerezeka ndi kupsa mtima, kuletsa mayankho.
• Kupsinjika kwa malekezero, dziko lokhumudwitsa, kupweteka kwa minofu ndi molumikizana, kusokonezeka kowonekera, kugunda kwamtima kofulumira.
• Kuphwanya kwam'mimba ndi m'mimba thirakiti.
• Thupi lawo siligwirizana ndi mawonekedwe a khungu - redness of the khungu, zotupa, urticaria, kutentha kwamphamvu.

Ndi mankhwala osokoneza bongo, kukula kwambiri kwa vuto la hypoglycemic, komwe kumayambitsa kudwala matenda ashuga sikuwonetsedwa.

Malangizo ogwiritsira ntchito mapiritsi

Kuzindikira kwa mankhwala a Glidiab MB akuwonetsa kuti mankhwalawa amalimbikitsidwa pochiza matenda a shuga mellitus limodzi ndi zolimbitsa thupi.

Monga lamulo, mankhwala nthawi zonse amagwira ntchito ngati njira yokhayo yotsitsira shuga. Pokhapokha pokhapokha pakhoza kuvomerezedwa pazovuta za matenda. Mwachitsanzo, kuphatikiza ndi kukonzekera kochokera ku gulu la Biguanide.

Mlingo wa mankhwalawa umaperekedwa potengera shuga pamimba yopanda kanthu, komanso maola awiri mutatha kudya.

Pa Glidiab, malangizo ogwiritsira ntchito amapereka malangizo awa:

1. Mapiritsi akulimbikitsidwa kuti amwe kamodzi patsiku, nthawi yokwanira ndiye m'mawa musanadye.
2. Pafupifupi, mlingo patsiku ndi 80 mg, kuphatikiza kwa okalamba (opitilira 65).
3. Ngati achire zotsatira zake ndizosakwanira, ndizovomerezeka kuti pang'onopang'ono muwonjezere mlingo ndi masiku 14.
4. Mlingo wambiri patsiku soposa 320 mg.

Ngati wodwalayo wasokoneza ntchito ya chiwindi ndi impso, ndiye kuti kusintha kwa mankhwala a Glidiab MV sikofunikira.

Mtengo wa mankhwalawa, komwe kuchuluka kwa zinthu ndi 80 mg (mapiritsi 60 pa paketi iliyonse) ndi 134 ma ruble. Mtengo wa mapiritsi 60 mgulu la 30 mg ndi ma ruble a 130. Glidiab MB ndiyokwera mtengo kwambiri, mtengo wake ndi 60 ma PC. 80 mg iliyonse ndi ma ruble 185.

Mitu ya mankhwalawa

Muzochitika zingapo, Glidiab sakulangizidwa kuti apereke chifukwa cha kupezeka kwa ma contraindication, kuthekera kwakukulu kwa zovuta kuchokera ku mtima wamkati ndi dongosolo la mtima.

Kusintha mankhwalawo ndi amodzi kapena mankhwala ena kuyenera kuchitika kokha ndi adokotala, palibe china.

Tiyeni tiganizire za fanizo mwatsatanetsatane:

• Formetin ndi mankhwala omwe amalimbikitsidwa pochiza matenda amishuga amtundu wa 2 pomwe chithandizo chamankhwala sichitha konse. Nthawi zambiri amalimbikitsidwa kuphatikizidwa ndi mankhwala omwe amachokera ku sulfonylurea.
• ali ndi ntchito yogwira glibenclamide, ndi zotumphukira za sulfonylurea. Mankhwala amalimbikitsa yogwira insulin, imapereka insulin yotulutsa shuga.
• Glibenclamide imalembedwa mtundu wachiwiri wa matenda ashuga, pomwe sizingatheke kulipira chipangizochi kudzera mu zakudya komanso masewera. Mlingo womwe umapangidwira malinga ndi zomwe zikuwonetsa shuga, amatha kusiyanasiyana kuchokera pa 2,5 mpaka 15 mg. Kuchulukana kwa kangapo patsiku.
• Amaryl - wothandizira wa hypoglycemic, adalembedwa kuti apereke chithandizo chamankhwala amtundu wachiwiri ngati mankhwala okhawo kapena osakanikirana ndi insulin kapena metformin. Monga lamulo, chithandizo ndi mankhwalawa chimachitika nthawi yayitali.

Mankhwala Glidiab ndi ofanana nawo ndi othandiza kwambiri pochiza matenda "okoma". Komabe, limodzi ndi katundu wabwino, ali ndi zotsutsana ndi zoyipa. Chifukwa chake, kusankhidwa kuyenera kuchitidwa kokha ndi dokotala.

Kumwa mapiritsi kumathandizira kuti thupi muchepetse kuchuluka kwa shuga ndikuwakhazikika pamlingo wofunikira. Koma, kuti athandize kugwiritsidwa ntchito bwino kwa mankhwalawa, wodwalayo ayenera kutsatira zakudya komanso masewera olimbitsa thupi kuti achulukitse mphamvu ya minofu yofewa.

Kodi mukuganiza bwanji pamenepa? Ndi mankhwala ati omwe adanenedwa ndi adotolo anu, ndipo mungauze chiyani za iwo malinga ndi zomwe mwakumana nazo?

Piritsi limodzi limaphatikizapo 80 mg gliclazide. Kuphatikiza apo: shuga ya mkaka, magnesium hydrosilicate, cellcrystalline cellulose, hydroxypropyl methyl cellulose, starch ya mbatata, sodium starch glycolate, magnesium stearate.

Piritsi limodzi la MB (kutulutsidwa kosinthidwa) kumaphatikizapo 30 mg gliclazide. Kuphatikiza apo: hydroxypropyl methylcellulose, aerosil, cellcrystalline cellulose, magnesium stearate.

Matenda a shuga odwala matenda ashuga

Kwa zaka zambiri osalimbana ndi ma DIABETES?

Mutu wa Bungwe: “Mudzadabwitsidwa kuti kumakhala kovuta motani kuchiritsa matenda a shuga tsiku lililonse.

Odwala omwe ali ndi matenda a shuga a zaka 41-50, izi zimakhazikitsidwa mu 11.3% ya milandu, ndipo pazaka za 51-60 zaka - mu 39,7% ya milandu. Komanso, titha kudziwa kuti pakati pa odwala matenda ashuga omwe tidawawona, 16 adawonetsa kusintha kwa ma electrocardiographic cicatricial atatha kupindika kwa myocardial, ndipo sizinasonyeze kuti angina pectoris m'mbiri ya odwala. Mwa odwala 27 omwe ali ndi matenda osokoneza bongo omwe amayambitsa matenda ashuga, kuchuluka kwa kufa komwe tidapereka pamwambapa, popanda kupweteka kwa infrction ya myocardial kudadziwika mwa odwala 5.

Pakadali pano, othandizira amadziwa bwino matenda okhudzana ndi matenda ashuga omwe amayamba chifukwa cha matenda omwe amapezeka kale. Mwa zina mwazinthu izi, glycosuria ndi hyperglycemia ndizochulukirapo kapena zosafunikira, odwala amafunikira kukonza zakudya komanso mankhwala osokoneza bongo a metabolism komanso pakadutsa nthawi yayitali atayamba kulowerera. Zikatero, ziyenera kuganiziridwa kuti kuperewera kwa mphamvu ya ziphuphu kunapangitsa kuti matenda asinthidwe am'mimba azitha kuwoneka bwino. Ponena za odwala omwe myocardial infarction inayamba mu mawonekedwe a shuga kale, kuwonongeka kwa kagayidwe kachakudya kamodzi kumayambiriro kwa pachimake mawonetsedwe a ischemic amawonetsedwa nthawi zambiri (A.R. Zlotopolsky ndi A.I. Khazanov, 1963, S. A. Sideraite ndi XX Kibarskis, 1964, Nielsen, 1967, D.F. Presnyakov ndi A.M. Kostenboim, 1970, ndi ena).

Funso la kufunikira kwa mankhwala a insulini pakukula kwa matenda a mtima ndi matenda a mtima sizingachitike mwanjira imeneyi, komabe, ntchito ina yoyesera imapangitsa kuti izi zitheke.

Zakudya regimen atheromatosis

Pick et al. (1959) anali ndi amuna pambuyo pang'ono pancreatectomy pachakudya chambiri chamafuta, kupatsanso atheromatosis mwanjira imeneyi. Pambuyo posamutsa abambo ku regimen yachilendo, atheromatosis sanachedwe, koma utsogoleri wa insulin unachepetsa kusintha kwa atheromatosis. Poyeserera O. N. Voskresensky (1962), mosiyana, insulin idachepetsa kusintha kwa kagayidwe kachakudya pakuyesayesa kwa atheromatosis mu akalulu. Umboni waukulu wotsutsana ndi gawo la insulini monga chifukwa cha pathogenesis ya atherosulinosis umaperekedwa ndi zidziwitso zamankhwala komanso zachigawo. Liebow et al. (1955), Perrin et al. (1962), Otto et al. (1964), Nielsen (1967) mwa kusanthula kwapadera sikunayambitse kusiyana koopsa kwa atherossteosis pakati pa odwala matenda ashuga omwe amathandizidwa ndi insulin, mankhwala a sulfonamide kapena zakudya zokha .

EG Moskovich (1958), Azerad et al. (1963) anayerekezera kutalika kwa mankhwala a insulin komanso Mlingo wa insulin ndi zovuta zakuchipatala komanso ma electrocardiographic owonetsa coronary atherosulinosis odwala omwe ali ndi matenda ashuga ndipo sanapeze kufanana. Pomaliza, chakuti odwala omwe ali ndi matenda a shuga achinyamata akhala akulandira insulin kwazaka zambiri osawonetsa zizindikiro za coronary kapena atherosulinosis, komanso odwala omwe ali ndi zaka zopitilira 40, umboni wowonjezera wa zamankhwala komanso wa electrocardiographic wa coronary sclerosis wapezeka ndi mitundu yonse ya zamankhwala, umapangitsa kukayikira kuthekera kwa kuthekera kwa insulin.Vutoli limakhala lovuta kwambiri chifukwa cha insulin pamagetsi a electrocardiogram komanso kugwiritsa ntchito insulin kwa odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto la kuperewera kwa mtima. Kafukufuku wina adawona kuchepa kwa mafunde a T, kusamutsidwa kwawo ndikusintha mawonekedwe a nthawi ya 5-T pa electrocardiogram pambuyo pa utsogoleri wa insulin kwa anthu onse opanda matenda a shuga (Mitschke, 1966) ndi anthu omwe ali ndi matenda a shuga mellitus (A. I. Romanov, 1964, N. I. Meshalkina, 1964, Mitschke, 1968).

The zikuchokera mankhwala

Pulogalamu yamankhwala Glidiab (mumitundu yapadziko lonse - Glidiab) ingagulidwe ngati mapiritsi ogwiritsira ntchito pakamwa. Kuphatikizika kwapadera ndi matekinoloje atsopano zimapereka kuwongolera kwa kuchuluka kwa kumasulidwa kwa chinthucho. Mtundu wokutira ndi multivariate: yoyera, yachikaso, kirimu.

Pa chithuza m'maselo a contour, mapiritsi 10 olemera 80 mg amamuunjikira ndi chophatikiza gliclazide. Amathandizira ndi zowonjezera zowonjezera: wowuma, magnesium stearate, sodium wowuma glycolate, shuga ya mkaka, hypromellose, MCC, talc.

Piritsi limodzi la mankhwala Glidiab MV lili ndi 30 mg ya gliclazide. Imathandizidwa ndi MCC, hypromellose, magnesium stearate, aerosil.

Kuthekera kwama pharmacological

Mosiyana ndi mzere wakale wa mankhwala, Glidiab sakhala woopsa komanso wogwira ntchito kwambiri, ndipo machitidwe ake a hypoglycemic amatengera kuti motsogozedwa ndi Glidiab:

• Kupanga kwa insulini Β-cell kumawonjezeka
• Kupanga kwa hepatic glycogen kumayambitsidwa,
• Mapuloteni a Receptor amaletsa gluconeogenesis,
• Endo native insulin imatheka,
• Kuphatikiza kwa shuga kwa mapuloteni ndi mafuta m'chiwindi kumatsekedwa,
• Chiwindi ndi mafupa amkati amamwa glucose mwachangu,
• Imachepetsa lipolysis mu zimakhala.

About Glidiab, kuwunika kwa madotolo kumatitsimikizira kuti limodzi ndi kugwiritsa ntchito mankhwalawa, insulin kukana kwa zotumphukira amachepetsa, ma enzymes ma cell, makamaka glycogen synthetase, amathandizidwa, nthawi pakati pa chakudya ndi insulin yowonjezera imachepetsedwa kwambiri.

Poyerekeza ndi mankhwala ena a gulu la sulfonylurea (glibenclamide, chlorpropamide), omwe amagwira ntchito makamaka mu gawo lachiwiri la kaphatikizidwe ka mahomoni, glycoslide imathandizira kubwezeretsa kutulutsa kokwanira kwambiri kwa insulin komanso kuchepetsa glycemia. Kuphatikiza pa kusintha kwa kagayidwe kachakudya kagayidwe kake, mankhwalawa amasintha kayendedwe ka magazi, kumachepetsa kuphatikiza kwa magazi ndi kuphatikizika, potero akuletsa mapangidwe.

Malinga ndi malangizo, gliclazide:

• Amasintha kukhuthala kwa mtima komanso kusasimbika,
• Zogwiritsidwa ntchito popewa microthrombosis,
• Imapangitsa chidwi cha makoma a mtima kupita ku adrenaline,
• Kubwezeretsanso thupi kwa thupi (kutsukidwa ku magazi),
• Imachepetsa zonse za cholesterol yathunthu, imakhala ndi anti-atherogenic zotsatira (kupewa ndi kuwongolera kwa atherosulinosis),
• Imayimitsa kukwera kwa retinopathy pa gawo lomwe silikukula.

Kugwiritsira ntchito kwa nthawi yayitali kwa Glidiab ndi odwala matenda ashuga omwe ali ndi nephropathy kumawongolera kuchuluka kwa mapuloteni mumkodzo. Mankhwalawa samathandizira pakukula, chifukwa ntchito yake yayikulu ndi kupanga insulini yoyambirira, yomwe siyimayambitsa hyperinsulinemia. Mankhwala amalola odwala matenda ashuga kwambiri kuti achepetse thupi, malinga ndi kusintha kwa moyo.

Pharmacokinetics wa mankhwala

Mlingo wa mayamwidwe a gliclazide m'mimba mwake pambuyo pakamwa pakumwa mankhwala ndiwokwera. Kumwa mlingo umodzi wa mankhwalawa (80 mg) kumapereka gawo lochulukirapo la gawo la magazi m'magazi 4 pambuyo pa maola anayi. Ma metabolabol mu chiwindi ndi biotransformed: makutidwe ndi okosijeni, hydroxylation ndi glucuronidation kumabweretsa mapangidwe a metabolites a 8 omwe samalowerera pankhani ya shuga. Imodzi mwa metabolites imatha kukhudza ma microcirculation. Zovunda zimachotsedwa impso (70%) ndi matumbo (12%). Mwanjira yake yoyambirira, 1% yokha ya Glidiab imachotsedwa.Kutha kwa theka-moyo kumakhazikitsidwa mu maola 8-11.

Ndani amasankhidwa Glidiab

Glidiab malinga ndi malangizo omwe amagwiritsidwa ntchito amalimbikitsidwa kwa odwala matenda ashuga omwe ali ndi matenda amtundu 2 wolimba, pakakhala zovuta monga microangiopathy. Amaloledwa kugwiritsa ntchito mankhwalawa monotherapy kapena chithandizo chovuta, pogwiritsa ntchito mitundu ina ya hypoglycemic. Glidiab amalembedwa pamodzi ndi mankhwala ena ochepetsa shuga kuti tiletse zovuta za matenda a shuga.

Munthawi zonsezi, mankhwalawa amapatsidwa mankhwala osakwanira osagwiritsa ntchito mankhwala osokoneza bongo kapena kuwonjezera pa kusintha kwa moyo.

Zitha kuvulaza gliclazide

Mankhwala okhala ndi glyclazide amatsutsana:

• Anthu odwala matenda ashuga a mtundu woyamba,
• Ndi kukula kwadwala 2 matenda ashuga,
• Ndi ketoacidosis,
• Odwala ndi insuloma
• M'mikhalidwe yomwe imayambitsa precom ndi odwala matenda ashuga,
• Anthu omwe ali ndi vuto laimpso komanso kwa chiwindi,
• Ndi microangiopathy yayikulu,
• Anthu odwala matenda ashuga omwe ali ndi hypersensitivity kuti sulfonylureas
• Mu nthawi ya matenda opatsirana,
• Pa mimba ndi mkaka wa m`mawere,
• Muubwana (palibe chidziwitso chokhudza zabwino ndi chitetezo),
• Maola 48 asanachitike komanso atachitidwa opaleshoni yayikulu.

Momwe mungagwiritsire ntchito mankhwalawa

Asanapange njira yodwala, dokotala amawunika momwe wodwalayo alili, msinkhu, magawo, komanso mavuto ena. Pamaziko a zizindikiro za kusala kudya ndi postprandial glycemia, komanso kupezeka kwa mankhwala ena opatsirana omwe wodwala amatenga nawo limodzi, muyezo watsiku ndi tsiku wa Glidiab amawerengedwa. Maganizo a wodwalayo pamankhwala amakumbidwanso.

Mankhwala okhazikika

Kwa Glidiab yosavuta, malangizo ogwiritsira ntchito amalimbikitsa kuchuluka kwa mankhwalawa - 80 mg / tsiku., Pakati - 160 mg, pazipita - 320 mg. Gwiritsani ntchito kawiri: m'mawa ndi madzulo, piritsi limodzi musanadye. Mu aimpso a impso, ngati creatinine chilolezo chochepa kuposa magawo 15, kusintha kwa mankhwalawa sikofunikira.

Za mitundu Glidiab MV

Mu odwala matenda ashuga (kuphatikiza gulu la gerontological), muyezo wa mankhwala womwe umatenga nthawi yayitali kuyambira 30-30 mg. Kuwongolera kwa chizolowezi kumatha masiku 14. Mlingo wambiri wa Glidiab MV, malinga ndi malangizo ogwiritsira ntchito, ndi 120 mg / tsiku .. Izi zikufanana ndi ma 4 pcs. mapiritsi. Mankhwalawa amamwa pakumwa m'mawa. Amaloledwa kutenga othandizira ena a hypoglycemic ofanana: biguanides, α-glucosidase enzyme inhibitors, insulin.

Zotsatira zoyipa

Za ndemanga za Glidiab zikuwonetsa kuti nthawi zina, kulandira chithandizo kumayendetsedwa ndi zochitika zosayembekezereka.

Anthu odwala matenda ashuga amadandaula za kutopa, chizungulire, kupweteka mutu, matenda am'mimba, khungu, kuyabwa, khungu

Zomwe zimapezeka kwambiri ndi hypoglycemia, paresis, thrombocytopenia, leukopenia, agranclocytosis, kuchepa magazi. Nthawi zambiri, zovuta zonse zimasinthidwa: atasiya kugwiritsa ntchito mankhwala, amachoka okha.

Kuti mupewe hypoglycemia ndi zina zosakomera, ndikofunikira kudziwa nthawi yoyenera kugwiritsa ntchito mapiritsi kudya zakudya, kupewa kufa ndi njala komanso kupewa mowa kwambiri.

Kuyanjana ndi Mankhwala ndi Glidiab

Bongo

Ndi kuwonjezeka kwa mlingo wambiri kuposa achire, pali kuthekera kwa kuchepa kwakukulu kwa glycemic indices. Mankhwala osokoneza bongo oopsa amatha kuthandizira kukulitsa glycemic coma. Ngati wovutikayo akudziwa ndi kumeza mapiritsiwo, amapatsidwa sucrose, dextrose, glucose kapena zakudya zotsekemera (zopanda zotsekemera zotulutsa).

Wodwala yemwe sakudziwa, mankhwalawa amaperekedwa kudzera mu minyewa (40% dextrose) kapena intramuscularly (1-2 g ya glucagon). Pambuyo pozindikira, wozunzidwayo amayenera kupatsidwa chakudya chambiri chamafuta kuti asayambenso kudwala.

Mlingo

Mankhwala apakamwa m'matumbo a mankhwala amatha kugulidwa mu mawonekedwe a mapiritsi. Zimapangidwa m'mitundu iwiri: Glidiab wamba (zigawo 6 za ma PC 10. Paketi iliyonse) ndi Glidiab MV, yemwe amadziwika ndi kutulutsidwa kwa zinthu zogwira ntchito (ma 3 kapena 6 a ma PC 10. Bokosi lililonse).

Pamtengo wosavuta wa Glidiab ndi wokwera mtengo kwambiri - ma ruble a 106-136. mapiritsi 60 a 80 mg. Pa Glidiab MV, mtengo muma pharmacie opezeka pa intaneti ndiwokwera pang'ono: ma ruble 160-166. mapiritsi 60 a 30 mg.

Malamulo osungira

Glidiab safuna mikhalidwe yapadera. Zipangizo zothandizira ziyenera kuyikidwa kutali ndi gwero lamvumbi, zowopsa zowopsa za radiation komanso chidwi cha ana, ziweto komanso olumala. Kutentha kwamtunda - mpaka 25 ° С. Mapiritsi amagwiritsidwa ntchito mkati mwa kumaliza ntchito: zaka 4 zamankhwala a Glidiab ndi 1 chaka chake chosinthika cha Glidiab MV. Pamapeto pa tsiku lotha ntchito lomwe linapangidwa ndi wopanga, mankhwalawo ayenera kutayidwa, chifukwa kugwira kwake ntchito kumachepetsedwa, ndipo kuchuluka kwa zotsatira zake kukukula.

Ma Synonyms ndi kufanana kwa Glidiab

Mankhwala oyamba ndi Gliclazide omwe ali ndi chinthu chomwecho, ena onse ndi opanga majini. Glidiab pamudindo amadziwika kuti ndiothandiza kwambiri. Potengera gawo logwira (gliclazide) ndi gulu (antidiabetic agents), ma fanizo ndi Glidiab ndi omwewo: Gliclazide, Diagnizid, Diatika, Diabinax, Diabefarm, Diabresid, Diabetesalong, Glioral, Predian, Gliclada, Glucostabil, Diabetes, Panmicron, Gluktam, Glisid, Medoklazid.

Mwa zina mwazomwe maanjidwe omwe adayikidwa ndi ofanana (mtundu wachiwiri wa matenda ashuga), otchuka kwambiri ndi awa: Lymphomyozot, Januvia, Multisorb, Bagomet, Glemaz, Metamin, Baeta, Apidra, Glyurenorm, Formmetin, Glyukobay, Novoformin, Levemir Flekspen, Formin, Levemir Penfill Avandia, Pioglar.

Malangizo owonjezera

Zotsatira zamankhwala ndi Glidiab zidzachepetsedwa kwambiri popanda kusintha kwa moyo wa anthu odwala matenda ashuga: chakudya chochepa chopatsa mphamvu, kuchita masewera olimbitsa thupi mokwanira, kuwongolera dziko la psychoemotional, kutsatira kugona ndi kupuma.

Ndikofunikira kuyang'anitsitsa mbiri yanu ya glycemic pofufuza kuchuluka kwa shuga kunyumba ndi mu labotale.

Ndi glucometer, glycemia wofulumira amayang'aniridwa pamimba yopanda kanthu m'mawa, maola awiri atatha kudya komanso asanagone, madzulo.

Anthu odwala matenda ashuga omwe amalandila mankhwala osakanikirana ndi insulin amayenera kuwunika mawonekedwe a magazi nthawi iliyonse ya jakisoni iliyonse. Ndikofunikira kutsatira kayendedwe kazosintha mu tsiku lonse, ndikuwunikanso kuwerenga kwapakati pa mwezi - kuchokera pakulankhula wina wa endocrinologist kupita ku msonkhano wina.

Mankhwalawa amatha kukhala ndi vuto pa psychomotor reaction. Izi zimatha kubweretsa mavuto poyendetsa, kuyendetsa makina ovuta, kugwira ntchito pamalo okwera komanso zinthu zina zoopsa zomwe zimafunikira chidwi.

Ngati Glidiab adawonetsedwa kwa mayi woyamwitsa, angagwiritsidwe ntchito pokhapokha posamutsa mwana kuti akwanitse kudya.

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Mafuta ndi shuga ndizosangalatsa kwambiri

Kodi shuga ndi shuga ndizofanana? Yoyamba ndi yosiyana popeza ndi manosaccharide, monga zimawonekera ndi kupezeka kwa kapangidwe kameneka kamodzi kokha. Shuga ndi disaccharide, chifukwa pali mafuta awiri omwe amaphatikizidwa. Chimodzi mwamafuta amenewa ndi glucose.

Zinthu izi zimayenderana m'chilengedwe chawo.

Madzi, zipatso, zipatso - magwero omwe shuga ndi shuga zimapangidwa bwino.

Poyerekeza ndi njira yopangira shuga (yomwe imapangidwa pamtengo wambiri kuchokera pazowerengeka zochepa), kuti mupeze shuga mu mawonekedwe ake oyera, ndikofunikira kugwiritsa ntchito njira yotsogola kwambiri komanso yowonjezera ntchito. Kupeza shuga m'magulu azakudya ndizotheka ndi cellulose.

Pazambiri zothandiza pazinthu ziwiri

Mafuta kapena shuga, ndi ati amene angakhale abwino? Palibe yankho limodzi ku funso ili. Tithana ndi katundu.

Chakudya chilichonse, munthu amadya shuga. Kugwiritsa ntchito kwake kwazindikiridwa kuti ndiwowonjezera mbale zamitundu yonse. Izi zidatchuka zaka 150 zapitazo ku Europe. Zowonjezeranso pazinthu zovulaza za betri iyi.

1. Mafuta amthupi. Dziwani kuti shuga omwe timadya amapangidwa ngati glycogen m'chiwindi. Muzochitika pamene mulingo wa glycogen umapangidwa mwapamwamba kwambiri kuposa momwe amafunikira, shuga yemwe wadyedwa amapanga imodzi mwamavuto ambiri osautsa - mafuta amana. Mwambiri, milandu yambiri imawoneka pamimba ndi m'chiuno.
2. Kukalamba koyambirira. Kugwiritsa ntchito kuchuluka kwa zinthu kumathandizira kuti pakhale makwinya. Izi zimayikidwa mu collagen ngati nkhokwe, zomwe zimapangitsa kuti khungu lizisalala. Palinso chinthu china chomwe kukalamba kumachitika - zovuta zapadera zimakopeka ndi shuga, zomwe zimawononga thupi, mwakutero kuwononga kuchokera mkati.
3. Kuledzera. Malinga ndi kuyesa pa makoswe, ndikugwiritsa ntchito pafupipafupi, kudalira kwakukulu kumawonekera. Izi zimakhudzanso anthu. Gwiritsani ntchito zomwe zimabweretsa kusintha kwapadera muubongo komwe kumafanana ndi cocaine kapena nikotini. Popeza wosuta sangathe ngakhale tsiku lopanda utsi wa chikonga, kotero popanda maswiti.

Mapeto ake amadzitsimikizira kuti kudya shuga wambiri ndizowopsa mthupi la munthu. Ndikwabwino kuchepetsa zakudya ndi shuga wambiri. Izi zidapezeka ndi ogwira ntchito ku University of California.Pambuyo pakuyesa kambiri, asayansi atsimikizira kuti mukagwiritsira ntchito pafupipafupi fructose, matenda a mtima wamtima amakula, komanso matenda ashuga.

Kuyesera kunachitika komwe anthu omwe amamwa zakumwa zowonjezera shuga amawonetsa kusintha kosafunikira m'chiwindi ndi mafuta osunga. Madokotala samalimbikitsa kuti atenge gawo ili. Ndipo onse chifukwa makhalidwe a anthu asintha kwambiri, chifukwa ndife opanda ntchito, chifukwa chomwe chimasungidwa mafuta nthawi zonse, chomwe chimakhudza mavuto azachipatala. Ambiri ayenera kuganizira izi.

Zingakhale zokoma bwanji?

Ndi funso la kusiyana pakati pa shuga ndi glucose omwe adatulutsa. Tsopano tiyeni tikambirane za iti omwe amatsekemera, shuga kapena shuga?

Shuga wochokera ku zipatso ndiwotsekemera pokoma, komanso ali ndi kumaliza. Koma kutenga shuga wa glucose nthawi zambiri kumachitika mwachangu, ndipo mphamvu zambiri zimawonjezeredwa. Pali lingaliro limodzi kuti ma disaccharides ndi okoma kwambiri. Koma ngati mukuyang'ana, pomwe yalowa mkamwa wamkamwa wamunthu, imapanga glucose ndi fructose polumikizana ndi malovu, pambuyo pake ndi kukoma kwa fructose komwe kumamveka mkamwa. Mapeto ake ali omveka: shuga panthawi ya hydrolysis imatulutsa bwino fructose, chifukwa chake imakhala yokoma kwambiri kuposa shuga. Ndizifukwa zonse zomwe zimamveka momwe glucose amasiyanirana ndi shuga.

Kunena mosalekeza za zoopsa za shuga, zomwe zimamveka lero kuchokera ku nyanga zonse zidziwitso, zimatipangitsa kuti tizikhulupirira kuti vutoli lilidi.

Ndipo popeza chikondi cha shuga chimasokonekera mu chikumbumtima chathu kuyambira pobadwa ndipo simukufuna kukana, muyenera kuyang'ana njira zina.

Glucose, fructose ndi sucrose ndi mitundu itatu yamatenda omwe ali ndi kufanana, koma pali kusiyana kwakukulu.

Amapezeka mwachilengedwe mu zipatso zambiri, masamba, zinthu mkaka ndi tirigu. Komanso, munthu amaphunzira kudzipatula ku zinthu izi ndi kuziphatikiza ndi ntchito zamanja kuti azilankhula.

M'nkhaniyi tikambirana za momwe glucose, fructose ndi sucrose zimasiyana, ndipo tidziwitsa amene ali othandiza / ovulaza.

Glucose, fructose, sucrose: kusiyana pankhani yamapangidwe. Tanthauzo

Kuchokera pamawonedwe a chemistry, mitundu yonse ya shuga imatha kugawidwa kukhala ma monosaccharides ndi ma disaccharides.

Monosaccharides ndi mitundu yosavuta kwambiri yamasamba omwe safuna chimbudzi ndipo amatengeka monga momwe aliri komanso mwachangu kwambiri. Njira yogwirira imayamba kale mkamwa, ndipo imathera mu rectum. Izi zimaphatikizapo shuga ndi fructose.

Ma disaccharides amapanga ma monosaccharides awiri ndipo makulidwe azigawidwa m'magawo awo (monosaccharides) pakukumba. Woimira wotchuka kwambiri wa ma disaccharides ndi sucrose.

Kodi sucrose ndi chiyani?

Sucrose ndi dzina lasayansi la shuga.

Sucrose ndi disaccharide. Molekyu yake imakhala kuchokera mu molekyu imodzi ya glucose ndi fructose imodzi . Ine.e. monga gawo la shuga lathu patebulo - 50% glucose ndi 50% fructose 1.

Sucrose mawonekedwe ake achilengedwe amapezeka muzinthu zambiri zachilengedwe (zipatso, ndiwo zamasamba, chimanga).

Zambiri zomwe zimafotokozedwa ndi "zotsekemera" zoyankhulira m'mawu athu zimachitika chifukwa zimakhala ndi sucrose (maswiti, ayisikilimu, zakumwa zoziziritsa kukhosi, zopangidwa ndi ufa).

Shuga wa tebulo amapezeka kuchokera ku beets shuga ndi nzimbe.

Zokonda za Sucrose Wotsekemera kuposa fructose koma wokoma kuposa glucose 2 .

Kodi shuga ndi chiyani?

Glucose ndiye gwero lenileni lamphamvu lamthupi lathu. Amaperekedwa ndi magazi ku maselo onse amthupi chifukwa cha zakudya zawo.

Dongosolo longa magazi monga "shuga wamagazi" kapena "shuga wamagazi" limafotokoza kuchuluka kwa shuga mkati mwake.

Mitundu ina yonse ya shuga (fructose ndi sucrose) imakhala ndi shuga m'magulu awo, kapena imasinthidwa kuti igwiritsidwe ntchito ngati mphamvu.

Glucose ndi monosaccharide, i.e. Sichifuna chimbudzi ndipo chimakamizidwa mwachangu kwambiri.

Pazakudya zachilengedwe, nthawi zambiri zimakhala gawo la zovuta zamankhwala - ma polysaccharides (wowuma) ndi ma disaccharides (sucrose kapena lactose (amapereka kukoma kwa mkaka).

Mitundu yonse itatu ya shuga - shuga, fructose, sucrose - shuga ndiye kukoma kochepa kwambiri 2 .

Kodi fructose ndi chiyani?

Fructose kapena "shuga wa zipatso" ndiwonso monosaccharide, monga glucose, i.e. odzipereka mwachangu.

Kukoma kokoma kwa zipatso zambiri ndi uchi kuli chifukwa cha zomwe amakhala ndi fructose.

Mwanjira yokoma, fructose imapezeka kuchokera ku shuga, nzimbe ndi chimanga chomwechi.

Poyerekeza ndi sucrose ndi glucose, fructose ali ndi kukoma kokoma kwambiri 2 .

Fructose yatchuka kwambiri pakati pa odwala matenda ashuga lero, chifukwa cha mitundu yonse ya shuga imakhala ndi mphamvu yochepa pa shuga 2. Komanso, ikagwiritsidwa ntchito limodzi ndi shuga, fructose imakulitsa kuchuluka kwa shuga omwe amasungidwa ndi chiwindi, komwe kumapangitsa kutsika kwake m'magazi 6.

Suprose, glucose, fructose ndi mitundu itatu ya shuga omwe amasiyana mu nthawi ya assimilation (osachepera glucose ndi fructose), kuchuluka kwa kutsekemera (pazofunikira kwa fructose) komanso momwe shuga imayambira m'magazi (osachepera fructose)

Momwe shuga amaleredwera

Mkulu akalowa m'magazi, amathandizira kutulutsa insulini, timadzi tosungunuka tomwe ntchito yake ndikuibweretsa m'maselo.

Pamenepo, imathira poizoni pomwepo "mu ng'anjo" kuti isanduke mphamvu, kapena kusungidwa ngati glycogen mu minofu ndi chiwindi kuti mugwiritse ntchito 3.

Ngati mulingo wa glucose m'magazi ndi wocheperapo ndipo zakudya zamafuta sizimachokera mu chakudya, ndiye kuti thupi limatha kudzipanga kuchokera ku mafuta ndi mapuloteni, osati kuchokera kwa omwe amapezeka mu chakudya, komanso kuchokera kwa iwo omwe akusungidwa m'thupi 4.

Izi zikufotokozera catabolism ya minofu kapena kuwonongeka kwa minofu amadziwika pomanga thupi komanso makina oyaka mafuta Mukamachepetsa zakudya zopatsa mphamvu.

CHINA KUSINTHA

Zotsatira za kafukufuku wamkulu kwambiri wamgwirizano pakati pa zakudya ndi thanzi

Zotsatira za kafukufuku wambiri wokhudzana ndi ubale pakati pa zakudya ndi thanzi, kumwa nyama mapuloteni ndi .. khansa

"Buku lambala 1 pazakudya, zomwe ndimalangiza aliyense kuti aziwerenga, makamaka masewera othamanga. Zaka makumi angapo kafukufuku wina wasayansi wotchuka padziko lonse lapansi adanenanso zambiri zokhudzana ndi mgwirizano pakati pa momwe amamwa nyama mapuloteni ndi .. khansa "

Andrey Kristov,
oyambitsa

Kuchepa kwa mphamvu ya minofu catabolism kumakhala kochulukirapo panthawi ya chakudya chochepa kwambiri: mphamvu ndi chakudya chamafuta ndi mafuta zimabwera pang'ono ndipo mapuloteni am'mimba amatha kuwonongeka kuti athe kuthandizira magwiridwe ofunikira (bongo, mwachitsanzo) 4.

Glucose ndiye gwero lofunikira lamphamvu kwa maselo onse mthupi. Ikagwiritsidwa ntchito, mulingo wa insulin ya m'magazi umakwera, womwe umasokoneza glucose m'maselo, kuphatikiza minofu ya minofu, kuti isanduke mphamvu. Ngati pali shuga wambiri, gawo lina limasungidwa monga glycogen, ndipo gawo lingasinthidwe kukhala mafuta

Kodi fructose amamwa bwanji?

Monga shuga, fructose imalowa mwachangu kwambiri.

Mosiyana ndi glucose, atatha kuyamwa kwa fructose shuga wamagazi amatuluka pang'onopang'ono ndipo sizitengera kulumpha lakuthwa mu insulin level 5.

Kwa odwala matenda ashuga omwe asokoneza insulin sensitivity, uwu ndi mwayi.

Koma fructose ali ndi gawo limodzi lofunikira polekanitsa.

Kuti thupi lizitha kugwiritsa ntchito fructose mphamvu, liyenera kusinthidwa kukhala glucose. Kutembenuka kumeneku kumachitika m'chiwindi.

Amakhulupirira kuti chiwindi sichitha kukonza ma fructose ambiri, ndipo, ngati pali zochuluka kwambiri mu zakudya, zochulukazo zimasinthidwa kukhala triglycerides 6, omwe adziwa zotsatira zoyipa zaumoyo, kuwonjezera chiwopsezo cha kunenepa kwambiri, mapangidwe a chiwindi chamafuta, etc. 9.

Malingaliro awa nthawi zambiri amagwiritsidwa ntchito ngati mkangano pamkangano "chovuta kwambiri ndi chiyani: shuga (sucrose) kapena fructose?".

Komabe, kafukufuku wina wasayansi akuti katundu wowonjezera kuchuluka kwa triglycerides m'magazi amakhala wofanana mu fructose, ndi sucrose, ndi glucose, pokhapokha atagwiritsidwa ntchito mopitilira muyeso (ochulukirapo zama calorie ofunikira tsiku ndi tsiku), ndipo osati pomwe ndi chithandizo chawo, gawo la zopatsa mphamvu limasinthidwa, mkati mwa zovomerezeka za 1.

Fructose, mosiyana ndi glucose, samakulitsa kuchuluka kwa insulin m'magazi ndipo imachita pang'onopang'ono. Izi ndi mwayi kwa odwala matenda ashuga. Kuchuluka kwa ma triglycerides m'mwazi ndi chiwindi, omwe amatsutsidwa kuti ndi ovuta kwambiri ku fructose kuposa glucose, alibe umboni wowonekera.

Momwe sucrose imamwidwira

Sucrose amasiyana ndi fructose ndi glucose chifukwa ndi disaccharide, i.e. chifukwa cha kukopeka ziyenera kudulidwa mu glucose ndi fructose . Njira imeneyi imayamba m'kamwa, kumapitirira m'mimba ndipo imatha m'matumbo ang'onoang'ono.

Komabe, kuphatikiza kwa shuga awa awiri kumabweretsa chidwi china: pamaso pa glucose, fructose yambiri imatengedwa ndipo insulin yambiri imakwera kwambiri , zomwe zikutanthauza kuwonjezeka kwakukulu kwa kuthekera kwamafuta 6.

Kudzikongoletsa yokha mwa anthu ambiri kumakhala kosakwanira ndipo pamlingo wina thupi limakana. Komabe, glucose akamadyedwa ndi fructose, kuchuluka kwake kumayamwa.

Izi zikutanthauza kuti mukamadya fructose ndi glucose (komwe ndi shuga), zotsatira zoyipa zaumoyo zitha kukhala zamphamvu kuposa pomwe amadyedwa payokha.

Ku West, masiku ano madokotala ndi asayansi akuda nkhawa kwambiri ndi momwe anthu ambiri amagwiritsira ntchito "chimanga cha chimanga" pachakudya, chomwe ndi mitundu yosiyanasiyana ya shuga. Zambiri zasayansi zikuwonetsa kuvulaza kwake kwambiri thanzi.

Suprose (kapena shuga) amasiyana ndi glucose ndi fructose chifukwa ndi chophatikiza chake. Kuvulaza thanzi la kuphatikiza koteroko (makamaka pokhudzana ndi kunenepa kwambiri) kumatha kukhala koopsa kuposa zigawo zake zokha

Nanga chabwino (chosavulaza): sucrose (shuga) ndi chiyani? fructose? kapena glucose?

Kwa iwo omwe ali ndi thanzi labwino, mwina palibe chifukwa chilichonse choopera mashuga omwe amapezeka kale pazinthu zachilengedwe: chilengedwe chimakhala chanzeru komanso zopanga zakudya m'njira yoti, kudya zokha, ndizovuta kwambiri kudzipweteka.

Zosakaniza mkati mwake ndizabwino, zimadzaza ndi CHIKWANGWANI NDI Madzi ndipo ndizosavuta kudya.

Zovuta zamasamba (onse shuga patebulo ndi fructose) zomwe aliyense akukamba lero ndi chifukwa chakugwiritsa ntchito kwawo mochuluka kwambiri .

Malinga ndi ziwerengero zina, Western Western amadya pafupifupi 80 g shuga patsiku (kupatula zomwe zimapezeka kale pazinthu zachilengedwe). Izi ndi pafupifupi 16% yazakudya zonse zopatsa mphamvu zopatsa thanzi - kwambiri kuposa zomwe zakulimbikitsidwa.

Kuti zimveke bwino, timamasulira chilankhulo cha zinthu: 330 ml ya Coca-Cola muli pafupifupi 30 g shuga 11. Izi, mokhazikika, ndizomwe zimaloledwa ...

Ndikofunikanso kukumbukira kuti shuga amawonjezeredwa osati pazakoma zotsekemera (ayisikilimu, maswiti, chokoleti). Itha kupezekanso mu "zokonda zokonda": msuzi, ketchups, mayonesi, mkate ndi soseji.

Kwa iwo, kudya fructose kumakhala koopsa kuposa shuga. kapena shuga wowona, popeza ali ndi index yotsika ya glycemic ndipo samatsogolera kukuwonjezeka kwa shuga m'magazi.

Chifukwa chake upangiri ndi uwu:

• muchepetsani, ndipo ndibwino kuchotsa pazakudya zamtundu uliwonse za shuga (shuga, fructose) ndi zinthu zatsopano zomwe zimapangidwa ndi iwo ambiri,
• osagwiritsa ntchito zokometsera zilizonse, chifukwa chowonjezera cha chilichonse chimadzaza ndi thanzi.
• pangani zakudya zanu kokha zakudya zonse zamagulu ndipo musawope shuga mumapangidwe awo: chilichonse chimakhala “chogwidwa” molingana ndi momwe.

Mitundu yonse ya shuga (onse shuga pathebulo ndi fructose) imakhala yovulaza thanzi mukamadyedwa kwambiri. Mawonekedwe awo achilengedwe, monga gawo lazinthu zachilengedwe, sizowopsa. Kwa odwala matenda ashuga, fructose imakhala yovulaza kuposa sucrose.

Pharmacodynamics ndi pharmacokinetics

Gliclazide ndi mankhwala amkamwa a hypoglycemic okhudzana ndi zotumphukira sulfonylureas M'badwo wachiwiri. Kuchita kwa mankhwalawa kumayambitsa kukhazikitsidwa kwa maselo β m'magazi, kupanga, kukulitsa chiwopsezo cha zotumphukira zake, ndikulimbitsa shuga insulin katulutsidwe zotsatira ndi kukondoweza kwa intracellular ntchito glycogen synthetase m'misempha minofu. Mankhwalawa amachepetsa nthawi kuyambira nthawi yomwe chakudya chimayambira mpaka pakuyamba kupanga insulinamachepetsa shuga wa postprandial, komanso kubwezeretsa choyambirira (choyambirira) pachimake insulin katulutsidwe (mosiyana ndi mankhwala ena sulfonylureasmakamaka ikugwira ntchito mu gawo lachiwiri).

Kuphatikiza pa kukhazikitsa kagayidwe kazachilengedwe gliclazide bwino kuyesapochepetsa pulateleti , komanso matenda a mtima kukhathamiritsa, kubwezeretsa kwa zochita zathupi parietal fibrinolysis.

Kuchiza kwa Glidiab kumachepetsa chidwi cha mitsempha ya magazi kuti iwonetsere, kumalepheretsa mapangidwe a. Zimalepheretsa kupita patsogolo kwa zomwe sizowonjezera (kumbuyo). Ndi chithandizo cha nthawi yayitali, kuchepa kwakukulu kumawonedwa, kukulira kumbuyomatenda ashuga nephropathy.

Kumwa mankhwalawa, chifukwa cha momwe amakhudzira siteji yoyambirira insulin katulutsidwe, sikhala limodzi ndi kunenepa kwambiri komanso imakondanso kuchepa kwa odwala onenepa ngati kuli koyenera.

Oyang'anira pakamwa gliclazide kumabweretsa kuyamwa pafupifupi kwathunthu m'mimba. TCmax mu seramu ndi maola 4 (mapiritsi a MV - maola 6-12). Kumangiriza kwa mapuloteni a plasma kuli pamlingo wa 90-95%. Kusintha kwa ma metabolic kumachitika m'chiwindi ndikutulutsa kwa zinthu zopanda ntchito. T1 / 2 ndi maola 8-11 (mapiritsi a MV - maola 16). Kupereka mawonekedwe mu mawonekedwe kumachitika makamaka ndi impso (pafupifupi 70%), komanso matumbo (12%). Pafupifupi 1% gliclazide yachotsa mkodzo osasinthika.

Kugwiritsa ntchito Glidiab ndikutsutsana kwathunthu mu:

• matenda ashuga ketoacidosis,
• Mtundu woyamba,
• matenda a shuga
• zolemetsa/ ,
• leukopenia,
• nyengo zopweteka, ndi kufunika kugwiritsa ntchito insulinkuphatikiza kuvulala, opareshonichachikulu amayaka,
• paresis am'mimba,
• matumbo kutsekeka,
• matenda ndi malabsorption chakudya ndikusintha hypoglycemia (kuphatikizapo matenda opatsirana)
• zanga zokha Hypersensitivity kuti gliclazide kapena mankhwala ena
• muubwana.

Zotsatira zoyipa

Zotsatira zoyipa komanso zoyipa kwambiri za Glidiab hypoglycemia, nthawi zambiri zimayamba chifukwa chophwanya mtundu wa mankhwala komanso zosakwanira zakudya mankhwala. Chizindikiro cha izi ndizosiyanasiyana ndipo chimatha kudziwonetsa :, ndi kumverera kwanjala, kutopa, mwadzidzidzi, osasamala, nkhawa, nkhanzakusakhazikika limatikuchepa kwapang'onopang'ono, kulephera kulolera, kuwonongeka kwamawonekedwekusowa thandizo aphasiakusokonezeka kwa malingaliro delirium, kulephera kudziletsa, spasmskulephera kudziwa Hypersomnia, kupuma kosazama ,, bradycardia.

Zotsatira zofunikira kwambiri za corking za Glidiab mankhwala amaonedwa kuti ndi zotsatira zoyipa zochokera m'mimba, zomwe zafotokozedwa (nseru, zovuta mu epigastrium ndi), kuphwanya hepatic ntchito (kuchuluka kwantchitochiwindi transaminase, cholestatic jaundice), (potenga mapiritsi ndi chakudya, zovuta kukomoka amachepetsa).

Nthawi zina leukopenia, thrombocytopenia ndi kuchepa magazi.

Glidiab, malangizo ogwiritsira ntchito

Kusankhidwa kwa Mlingo wa mankhwala Glidiab amachitika payekhapayekha malinga ndi mawonetseredwe azachipatala NIDDM ndi msinkhu glycemia, yomwe imayeza pamimba yopanda kanthu, komanso pambuyo pa maola awiri mutatha kudya.

Poyamba, kudya kwa tsiku ndi tsiku piritsi la 1 Glidiab 80 mg kapena piritsi la 1st Glidiab MV 30 mg ndikulimbikitsidwa. Mlingo wamba watsiku ndi tsiku ndi 160 mg ndi 60 mg, ndipo kutalika kwake ndi 320 mg ndi 120 mg, motero, pamapiritsi ndi mapiritsi a MV. Mapiritsi achire a Glidiab 80 mg amatengedwa mphindi 30-60 musanadye kawiri m'maola 24 (m'mawa ndi madzulo). Mapiritsi MV 30 mg amasonyezedwa kuti amatengedwa kamodzi m'mawa uliwonse mukamadya kadzutsa. Kuchulukitsa Mlingo angathe kuchitidwa ndi imeneyi osachepera masiku 14.

Okalamba odwala ndi odwala omwe ali ndi matenda a impso (ndi CC 15-80 ml / min) safuna kusintha kwa mlingo.

Kuchita

Kutsika kwa mphamvu ya hypoglycemic ya Glidiab kumawonedwa ngati kugwiritsidwa ntchito kwake ndi glucocorticoids, barbituratesamanditititita (Terbutaline, , Ritodrin,,), okana calcium thiazide okodzetsakaboni anhydrase inhibitors (), Triamteren, , , Asparaginase, , Diazoxide, , , , Glucagon., ndi chithokomiro cha chithokomiro (kuphatikiza).

Kulandila kwa Joidi kwa Glidiab ndi mtima glycosides kumawonjezera chiopsezo cha mapangidwe chamkati extrasystole.

Zotsatira za β-blockers ,,, Guanethidine imatha kuzindikira zodwala matenda hypoglycemia.

Malo osungira

Kutentha kwakukulu kosungirako kwa mapiritsi ndi mapiritsi a MV Glidiab ndi 25 ° C.

Anthu omwe ali ndi matenda a shuga a mtundu wachiwiri sakhala okhazikika nthawi zonse amathanso kukhala ndi shuga wamagazi ambiri pakudya komanso masewera olimbitsa thupi. Chifukwa chake, odwala matenda ashuga ena amagwiritsa ntchito othandizira a hypoglycemic, makamaka Glidiab.

Mankhwalawa amathandizira kukhazikika pamlingo wa shuga m'magazi, ndikuwonjezera mphamvu ya zakudya ngati wodwala matenda ashuga akudwala kunenepa kwambiri. Komanso, mukamagwiritsa ntchito Glidiab MV 30, nsonga ya insulin secretion imabwezeretseka.

Kodi ndingagule bwanji mankhwala a Glidiab? Mu mankhwala, mtengo wa mankhwala ndi ma ruble a 120-200. Mtengo wake umadalira kuchuluka kwa mankhwala opangira piritsi. Glidiab MB 30 mg ndi 80 mg amapezeka pamsika.

Njira yamachitidwe ndikuwonetsa ntchito

Glidiab MV ndi wothandizira waogoglycemic wa gulu la sulfonylurea zotumphukira za m'badwo wachiwiri. Mankhwalawa amakhala ndi gliclazide ndi zotuluka. Glyclazide piritsi limodzi lili ndi 80 mg kapena 30 mg.

Kodi chigawo chogwira ntchito cha mankhwalawo chimagwira ntchito bwanji? Glyclazide pa mayamwidwe imalimbikitsa minofu glycogen synthetase ntchito ndi insulin katulutsidwe. Komanso, izi zimapangitsa kuti inshuwaransi ikhale yachinsinsi, komanso imathandizira kuti chiwopsezo cha zotumphukira ziwonongeke.

Komanso, gliclazide imathandizira kuchepetsa kusiyana pakati pa kudya ndi kuyambika kwa gawo lobisika la insulin. Ngati mungayang'ane malangizo omwe angagwiritsidwe ntchito a Glidiab, mutha kudziwa kuti mukamagwiritsa ntchito mapiritsi, kuchuluka kwa hyperglycemia kumachepa, ndipo nsonga yoyambirira ya insulin secretion imabwezeretseka.

Zinthu zonsezi zimakhudza kagayidwe kazakudya ndi michere. Ngati mukukhulupirira malangizowo, ndiye kuti Glidiab MV amathandizira kuchepetsa kuphatikiza ndi kuphatikizika kwa mapulosi, komanso munthawi imodzimodziyo kusintha matendawa.Mwachidule, pogwiritsa ntchito mapiritsi, mwayi wopita patsogolo kwa micothrombosis ndi atherosulinosis umachepetsedwa kwambiri.

Kafukufuku adawonekeranso kuti wothandizira wa hypoglycemic amathandizira kuti muchepetse kukula kwa zovuta monga matenda ashuga retinopathy pa gawo lomwe silikukula. Kuphatikiza apo, kugwiritsa ntchito mapiritsi a Glidiab MV kungakulitse kwambiri mphamvu ya mankhwala othandizira odwala onenepa kwambiri.

Ndikufuna kudziwa kuti ma metabolites a mankhwalawa amachotsedwa pamodzi ndi mkodzo m'njira yosasinthika, komanso palinso ndowe mu mawonekedwe a metabolites.

Malangizo ogwiritsira ntchito mankhwalawa

Ndi munthawi ziti zomwe zikuyenera kugwiritsa ntchito mapiritsi a Glidiab 80? Malangizowo akunena kuti ndikofunikira kugwiritsa ntchito mankhwalawa pochiza matenda a shuga 2, ngati mankhwala othandizira pakudya ndi masewera olimbitsa thupi samathandizira kukhazikika kwa shuga.

Molumikizana ndi mankhwala ena, Glidiab MB sigwiritsidwa ntchito kwambiri. Koma ziyenera kudziwika kuti zotsatira za hypoglycemic za mankhwalawa zitha kuchuluka ngati, limodzi ndi mankhwala osokoneza bongo, kudya ndikusewera masewera ndizoyenera.

Momwe mungamwere mankhwala? Mlingo woyambirira ndi 80 mg. Komanso, pafupipafupi kugwiritsa ntchito ndi 2 kawiri pa tsiku - m'mawa ndi madzulo. Ndi bwino kumwa mapiritsi 30-60 mphindi musanadye.

Ngati mulingo wocheperako wa 80 mg ulibe hypoglycemic, ndiye kuti mwapang'onopang'ono kuchuluka kwake. Nthawi zambiri, matenda amtundu wa 2 shuga, muyezo wa 160 mg ndi wokwanira. Mlingo woyenera wovomerezeka wa mankhwalawa ndi 320 mg.

Koma tiyenera kukumbukira kuti ndi kuchuluka kwa Mlingo, mwayi wopita patsogolo wa hypoglycemia ndi zovuta zina kumakula kwambiri.

Kuyanjana Ndi Mankhwala Osokoneza Ubwenzi

Kumbukirani kuti mankhwalawa amatha kuonjezera mphamvu ya hypoglycemic ya mankhwala a Glidiab MB. Chifukwa chake, malangizowo amanenanso kuti mankhwalawa amayenera kuphatikizidwa mosamala kwambiri ndi histamine H2-receptor blockers, mankhwala osapatsa mankhwala a antiidal, othandizira antifungal, ACE inhibitors.

Mankhwala ochepetsa chifuwa, ma beta-adrenoblockers, anticoagulants osadziwika, anabolic steroids, Mao inhibitors, salicylates ndi ena amathanso kukulitsa zotsatira za hypoglycemic.

Ndiye chifukwa chake, musanagwiritse ntchito mapiritsi a Glidiab, muyenera kuphunzira mosamala malangizo ndikuyang'ana dokotala.

Mwa contraindication kugwiritsa ntchito mapiritsi angadziwike:

1. Matenda a shuga a Mtundu woyamba amadalira insulin.
2. Matenda a shuga ketoacidosis.
3. Zabwino kapena zaphokoso. Kuphatikiza apo, kutsutsana kokhwima ndi hyperosmolar coma.
4. Leukopenia
5. Nthawi yapakati.
6. Nthawi yochepetsetsa.
7. Kulephera kwakukulu kwa hepatic ndi aimpso.
8. Mikhalidwe yomwe imayendetsedwa ndi kuphwanya njira ya mayamwidwe akudya, komanso kukula kwa hypoglycemia. Zinthu zoterezi zimaphatikizira matumbo, kutsekeka kwa m'mimba komanso matenda opatsirana.
9. Chiwopsezo kwa zigawo za mapiritsi.
10. Mikhalidwe yomwe insulin mankhwala ingafunikire. Izi zimaphatikizapo kupsa, kuvulala, kapena opaleshoni.
11. Mowa
12. Febrile syndrome.

Komanso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala kwa anthu omwe ali ndi vuto la chithokomiro.

Ndemanga ndi zoyipa za Glidiab

Ndi ndemanga ziti za Glidiab? Anthu odwala matenda ashuga amayankha bwino mankhwalawo. Anthu ambiri amakopeka ndi mtengo wotsika mtengo wa mankhwalawo, komanso zizindikiro zapamwamba kwambiri.

Komanso, Gladiab, malinga ndi odwala matenda ashuga, ndiabwino chifukwa samayambitsa zotsatira zoyipa pamankhwala ochepa. Chikhalidwe chinanso cha mankhwalawa kwa anthu ndikuti zimawonjezera mphamvu ya mankhwala azakudya.

Zotsatira zoyipa zomwe mankhwala a hypoglycemic angayambitse? Malinga ndi malangizo, mankhwalawa angayambitse:

• Kuphwanya kwa endocrine dongosolo.Amawoneka mu mawonekedwe. Koma dziwani kuti kuphatikiza uku kumachitika pokhapokha ngati pali mankhwala osankhidwa bwino.
• Kukwiya, kugona, kuzunzidwa, kunjenjemera miyendo, mutu, chizungulire, kutopa kwambiri.
• Kuchepetsa maonedwe owoneka.
• Aphasia.
• Bradycardia
• Kupuma kosapumira.
• Delirium.
• Thrombocytopenia, kuchepa magazi, leukopenia.
• Thupi lawo siligwirizana.
• Matumbo dongosolo. Munthu amatha kudwala matenda otsekula m'mimba, kumva kupsinjika kwa dera la epigastric, nseru, matenda anorexia, cholestatic jaundice, kuchuluka kwa hepatic transaminases.

Nthawi zambiri, mavuto amadzisinthira atasiya kumwa mankhwalawo ndikulandira chithandizo chamankhwala choyenera.

Pharmacological zochita za glidiab mv

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imapangitsa secretion ya insulin ndi ma pancreatic cell. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Zikuwoneka, zimapangitsa ntchito ya ma intracellular enzymes (makamaka, minofu glycogen synthetase). Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Amabwezeretsa chiyambi choyambirira cha insulin katemera, amachepetsa chiwerengero cha hyperglycemia pambuyo pake.

Glyclazide imachepetsa kuphatikiza kwa mapulateleti ndi kusakanikirana, imachepetsa kukula kwa parietal thrombus, ndikuwonjezera ntchito ya mtima. Matendawa mtima kukhathamira. Ili ndi antiatherogenic katundu: imatsitsa kuchuluka kwa cholesterol kwathunthu ndi cholesterol / LDL m'magazi, kumachulukitsa kuchuluka kwa cholesterol / HDL, komanso kumachepetsa kuchuluka kwa zopitilira muyeso. Zimalepheretsa kukula kwa microthrombosis ndi atherosulinosis. Amasintha kusintha kwakachulukidwe. Imachepetsa mphamvu ya mtima ku adrenaline.

Ndi diabetesic nephropathy yogwiritsa ntchito gliclazide nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika.

Pomaliza

Suprose, shuga ndi fructose onse amamva kukoma, koma fructose ndiye okoma kwambiri.

Mitundu yonse itatu ya shuga imagwiritsidwa ntchito m'thupi mphamvu: glucose ndiye gwero lamphamvu lamphamvu, fructose amasandulika kukhala glucose mu chiwindi, ndipo sucrose idagawika zonse ziwiri.

Mitundu yonse itatu ya shuga - shuga, frutose, ndi sucrose - imapezeka mwachilengedwe muzakudya zambiri zachilengedwe. Palibe mlandu uliwonse wogwiritsa ntchito.

Zowononga thanzi ndizochulukirapo. Ngakhale kuti kuyesayesa kumachitika kuti apeze "shuga wowopsa", kafukufuku wasayansi satsimikizira mosakhalitsa kuti alipo: asayansi amawona zotsatirapo zoipa zaumoyo akamagwiritsa ntchito mulingo waukulu kwambiri.

Ndikofunika kupeweratu kugwiritsa ntchito zotsekemera zilizonse, ndikusangalala ndi kukoma kwa zinthu zachilengedwe zomwe zimapezeka (zipatso, masamba).

Mphamvu za sucrose ziyenera kuganiziridwa pofotokoza za fizikisi ndi umagwirira. Katunduyu ndi disaccharide wamba, koposa zonse imapezeka mum nzimbe ndi beets.

Ikalowa m'matumbo, kapangidwe kake ka sucrose kamawonongeka ndikosavuta ma carbohydrate - fructose ndi glucose. Ndiye gwero lalikulu lamphamvu, popanda zomwe zimachitika kuti thupi lizigwira ntchito ndizosatheka.

Ndi katundu wanji amadziwika ndi chinthu, komanso zomwe zimakhudza thupi, zimawululidwa pazinthu izi.

Kapangidwe ndi zinthu za thunthu

Sucrose (mayina ena - nzimbe kapena sucrose) ndimachotsa m'gulu la oligosaccharides okhala ndi zotsalira za 2-10 monosaccharide. Muli zinthu ziwiri - glucose wa alpha ndi beta fructose. Mitundu yake yamafuta ndi C 12 H 22 O 11.

Thupi lomwe limakhala loyera limayimiriridwa ndi makristalo owoneka bwino a monoclinic. Unyinji wosungunuka ukakhazikika, caramel imapangidwa, i.e. mawonekedwe amourphous wopanda mtundu.Mafuta a nzimbe amasungunuka kwambiri m'madzi (H 2 O) ndi Mowa (C 2 H 5 OH), osungunuka pang'ono mu methanol (CH 3 OH) ndipo pafupifupi osalowa mu diethyl ether ((C 2 H 5) 2 O). Zinthu zimatha kusungunuka pa kutentha kwa 186 ℃.

Suprose sikuti ndi aldehyde, koma imawerengedwa kuti ndi yoyatsira yofunika kwambiri. Ngati sucrose yatenthedwa ndi yankho la ammonia Ag 2 O, ndiye kuti "galasi lasiliva" silidzachitika. Kutenthetsera zinthu ndi Cu (OH) 2 sikungapangitse kuti mupangidwe ndi mkuwa wamkuwa. Ngati mumaphika yankho la sucrose limodzi ndi hydrogen chloride (HCl) kapena sulfuric acid (H 2 SO 4), kenako ndikusintha ndi alkali ndikuwupatsa kutentha pamodzi ndi Cu (OH) 2, ndiye kuti mpweya wofiyira umapezeka kumapeto.

Mothandizidwa ndi madzi, shuga ndi fructose amapangidwa. Pakati pa ma iscrose isomers omwe ali ndi mtundu womwewo wamapangidwe, lactose ndi maltose ndizodzipatula.

Ndi zinthu ziti zomwe zimapezeka?

Mwachilengedwe, disaccharide iyi ndiyofala. Suprose imapezeka mu zipatso, zipatso, ndi zipatso.

Mochulukirapo, amapezeka mumankhwala a nzimbe ndi shuga. Nzimbe ndizofala kumadera otentha ndi ku South America. Mapulogalamu ake ndi 18-21% shuga.

Tiyenera kudziwa kuti zimachokera ku nzimbe kuti 65% yazopanga shuga padziko lonse lapansi zimapezeka. Mayiko otsogola kupangira malonda ndi India, Brazil, China, Thailand, Mexico.

Beetroot ili ndi pafupifupi 20% sucrose ndipo ndiomera wazaka ziwiri. Zomera mu Ufumu wa Russia zinayamba kukula, kuyambira m'zaka za zana la XIX. Pakadali pano, Russia ikumakula ma beets okwanira kudzidyetsa ndikutumiza shuga wa shuga kunja.

Munthu samazindikira kuti m'zakudya zake wamba amakhala padera. Imapezeka mu zakudya zotere:

• masiku
• mikanda
• prunes
• makeke ophikira
• marmalade
• zoumba
• irge
• apulo marshmallow,
• medlar
• uchi uchi
• mapulo madzi
• nsapato zotsekemera
• nkhuyu zouma
• kuyamwa
• vwende
• Persimmon

Kuphatikiza apo, gawo lalikulu la sucrose limapezeka mu kaloti.

Kuthandiza kwa sucrose kwa anthu

Shuga ikangolowa m'magawo am'mimba, imagawika m'mafuta osavuta. Kenako zimatengedwa kudzera m'magazi kupita kuzinthu zonse zamthupi.

Chofunika kwambiri pakupasuka kwa sucrose ndi glucose, chifukwa ndiye gwero lalikulu la mphamvu yazinthu zonse zamoyo. Chifukwa cha izi, 80% ya mtengo wamagetsi imalipidwa.

Chifukwa chake, kufunikira kwa sucrose kwa thupi la munthu ndi motere:

1. Kuwonetsera kugwira ntchito kwathunthu kwa mphamvu.
2. Kupititsa patsogolo ntchito za ubongo.
3. Kubwezeretsa ntchito yoteteza ku chiwindi.
4. Kuthandizira ntchito ya minyewa ndi minyewa yolimba.

Kuperewera kwa Sucrose kumayambitsa kukwiya, mkhalidwe wopanda chidwi, kutopa, kusowa mphamvu komanso kukhumudwa. Kuchuluka kwa zinthu kumayambitsa kuchuluka kwa mafuta (kunenepa kwambiri), matenda osakhazikika, kuwonongeka kwa minofu ya mano, matenda amkamwa, kukondoweza, kuyamwa, komanso kumakulitsa mwayi wa hyperglycemia ndi kukula kwa matenda ashuga.

Kumwa mowa mwauchidakwa kumawonjezeka ngati munthu amakhala akusunthasuntha, atanganidwa ndi ntchito zaluntha, kapenanso kuledzera kwambiri.

Ubwino wa ma sucrose constituent - fructose ndi glucose - ayenera kuganiziridwa padera.

Fructose ndiye chinthu chomwe chimapezeka zipatso zambiri zatsopano. Imakhala ndi kadzutsa wokoma ndipo sikakhudza glycemia. Mndandanda wa glycemic ndi magawo 20 okha.

Fructose yowonjezera imayambitsa matenda a cirrhosis, kunenepa kwambiri, matenda a mtima, gout, kunenepa kwambiri kwa chiwindi, komanso kukalamba msanga. Popita kafukufuku wa asayansi, zidatsimikizika kuti chinthuchi chimathamanga kwambiri kuposa glucose chimayambitsa zizindikiro za ukalamba.

Glucose ndiye mtundu wa michere yambiri padziko lapansi. Zimayambitsa kuchuluka kwa glycemia ndipo kumadzaza thupi ndi mphamvu yofunikira.

Chifukwa chakuti glucose amapangidwa kuchokera kuzakudya zam'mimba, kudya mopitirira muyeso kwa zinthu zomwe zimakhala zosavuta ma starches (mpunga ndi ufa wa premium) kumabweretsa kuwonjezeka kwa shuga m'magazi.

Njira yotereyi imaphatikizanso kuchepa kwa chitetezo chokwanira, kulephera kwa impso, kunenepa kwambiri, kuchuluka kwa nseru za lipid, kuchiritsa kwamabala pang'ono, kusweka kwamitsempha, stroko komanso mtima.

Phindu ndi zovulaza za zotsekemera zotengera

Anthu ena sangathe kudya shuga yemwe amakhala bwino kwa ena. Kufotokozera kofala kwa izi ndi matenda amtundu wa shuga.

Ndiyenera kugwiritsa ntchito zachilengedwe komanso. Kusiyana pakati pa kupanga ndi zotsekemera zachilengedwe ndi zopatsa mphamvu zosiyanasiyana komanso zowononga thupi.

Zinthu zopanga (aspart ndi sucropase) zili ndi zovuta zina: kapangidwe kake ka mankhwala kamayambitsa ma migraines ndikukulitsa mwayi wopezeka ndi zotupa zoyipa. Kuphatikiza kokhako kwa zotsekemera zotsekemera kumangokhala zopatsa mphamvu zochepa.

Pakati pa zotsekemera zachilengedwe, sorbitol, xylitol ndi fructose ndizodziwika kwambiri. Amakhala ndi kalori yayitali, motero, chifukwa chomwa mowa kwambiri zimayambitsa kunenepa kwambiri.

Chothandiza kwambiri ndi stevia. Zothandiza zake zimaphatikizidwa ndi kuwonjezeka kwa chitetezo chamthupi, kuphatikiza kwamphamvu kwa kuthamanga kwa magazi, kubwezeretsanso khungu ndi kuthetsa kwa candidiasis.

Kugwiritsa ntchito mankhwala otsekemera kwambiri kungapangitse zotsatirazi zotsatirazi:

• nseru, kudzimbidwa, chifuwa, kugona pang'ono, kupsinjika, arrhythmia, chizungulire (aspartame kudya),
• thupi lawo siligwirizana, kuphatikizapo dermatitis (ntchito suklamat),
• Kukula kwa chosaopsa ndi neoplasms yoyipa (kutenga saccharin),
• khansa ya chikhodzodzo (kumwa ndi sorbitol),
• kuphwanya mulingo wa acid-base (kugwiritsa ntchito fructose).

Chifukwa cha chiwopsezo chokhala ndi ma pathologies osiyanasiyana, zotsekemera zimagwiritsidwa ntchito pazochepa. Ngati sucrose sangathe kudya, pang'onopang'ono mutha kuwonjezera uchi ku zakudya - zotetezeka komanso zopatsa thanzi. Kugwiritsa ntchito uchi mopitirira muyeso sikubweretsa kudumphira mu glycemia ndikukulitsa chitetezo chokwanira. Komanso madzi a mapulo, omwe amangokhala ndi 5% sucrose, amagwiritsidwa ntchito ngati zotsekemera.

Fructose nthawi zambiri amagwiritsidwa ntchito ngati zotsekemera anthu omwe ali ndi matenda ashuga. Glucose ndiosavomerezeka kwa iwo. Nthawi zina, mutha kugwiritsa ntchito fructose, ndipo pazomwe sizoyenera. Kodi pali kusiyana pakati pa shuga, fructose ndi sucrose?

Anthu ambiri amadziwa kuti fructose ndi glucose ndi "mbali ziwiri za ndalama imodzi," kutanthauza, zigawo za sucrose. Anthu odwala matenda a shuga amadziwa kuti saloledwa kugwiritsa ntchito maswiti pazakudya. Chifukwa cha izi, anthu ambiri amakonda zopangidwa ndi shuga wa zipatso, koma kodi ndizotetezeka monga momwe zimawonekera poyamba? Tiyeni tiyese kudziwa kuti pali kusiyana kotani pakati pa ma monosaccharides awiri.

Kodi zipatso monosaccharide ndi chiyani?

Fructose ndi glucose palimodzi ndi molekyulu imodzi ya sucrose. Asayansi atsimikizira kuti zipatso za monosaccharide ndizochulukirapo kuposa theka la glucose. Ndizosangalatsa, koma ngati sucrose ndi zipatso monosaccharide zimagwiritsidwa ntchito zomwezo, zotsalazo zimakhalanso zokoma. Koma potengera zomwe zili ndi caloric, sucrose imapitilira zomwe zimapezeka.

Zipatso monosaccharide ndizowoneka bwino kwa madokotala, amalangizidwa kuti azigwiritsa ntchito m'malo mwa shuga. Izi ndichifukwa choti imalowa m'magazi pang'onopang'ono kuposa shuga. Nthawi yovomerezeka ili pafupifupi mphindi 20. Sizikhumudwitsa kutulutsa insulin yambiri. Chifukwa cha malowa, odwala matenda ashuga amatha kukana shuga pogwiritsa ntchito zinthu zomwe zimachokera ku monosaccharide iyi. Uku ndiye kusiyana kwakukulu pakati pa fructose ndi sucrose ndi glucose.

Koma sizili zovulaza, chifukwa, zochulukirapo 50 g patsiku zimayambitsa kusweka ndi kutulutsa. Asayansi azindikira kuti minofu ya adipose imawonjezeka kwambiri kuchokera ku fructose.Izi ndichifukwa choti zimakonzedwa m'chiwindi, ndipo chiwalochi ndichoperewera mwanjira yakukwaniritsa zinthu. Pamene kuchuluka kwa monosaccharide kulowa mthupi, chiwindi sichitha, ndipo chinthuchi chimasinthidwa kukhala mafuta.

Ubwino wa sucrose ndi shuga wa zipatso mu shuga

Shuga kapena shuga, zomwe ndizofanana zomwezo, ndizoletsedwa kugwiritsa ntchito shuga, chifukwa chinthu ichi chimayambitsa zotsatira zamthupi - kutulutsa kwa insulin. Ndipo ngati insulin sikokwanira (1 mtundu wa matenda) kapena kapamba wanu safuna kutenga insulin yanu (matenda a 2), kuchuluka kwa glucose kumakwera.

Ubwino wa fructose mu shuga siabwino. Itha kugwiritsidwa ntchito, koma ochepa. Ngati munthu akusowa kutsekemera komwe kumaperekedwa ndi zipatso monosaccharide patsiku, ndibwino kugwiritsa ntchito zina zotsekemera kuwonjezera. Mtundu wachiwiri wa shuga, shuga ndiwowopsa kwa odwala kuposa fructose. Ndikofunika kupewa izi pazinthu zonse: onetsetsani kuti zikuchokera bwanji ndipo musaphike mbale zopangidwa zokha ndi kusungidwa ndi sucrose.

Kusiyana pakati pa fructose ndi sucrose

1. Zipatso monosaccharide sizovuta kupangika, kotero ndizosavuta kuyamwa. Shuga ndi disaccharide, kotero kuyamwa kumatenga nthawi yayitali.
2. Phindu la fructose kwa odwala matenda ashuga ndikuti insulin siyikhudzidwa ndi kuyamwa kwake. Uku ndiye kusiyana kwake kwakukulu ndi shuga.
3. Monosaccharide iyi imakoma kwambiri kuposa sucrose; Pankhaniyi zilibe kanthu kuti shuga kapena fructose adzagwiritsidwa ntchito mu mbale, kulekerera kwa zinthu izi kuyenera kukumbukiridwa.
4. Mchere wa zipatso sizimapatsa mphamvu “mwachangu”. Ngakhale wodwala matenda ashuga atasowa kwambiri shuga (wokhala ndi hypoglycemia), zinthu zomwe zimakhala ndi fructose sizingamuthandize. M'malo mwake, muyenera kugwiritsa ntchito chokoleti kapena cube ya shuga kuti mubwezeretsenso msanga momwe muliri m'magazi.

Zotsatira za caloric za monosaccharides, Mlingo wovomerezeka

Glucose ndi fructose ali ndi zofanana zofanana. Omalizirawo ndi apamwamba ngakhale khumi ndi awiri - 399 kcal, pomwe monosaccharide woyamba - 389 kcal. Ndizotheka kuti zopatsa mphamvu za zinthu ziwiri sizosiyana kwambiri. Koma ndizopindulitsa kwambiri kugwiritsa ntchito fructose mumadontho ang'onoang'ono a shuga. Kwa odwala oterowo, mtengo wovomerezeka wa monosaccharide patsiku ndi 30 g. Ndikofunikira kutsatira izi:

• Katunduyu simalowa mthupi osati mwa mtundu wake, koma mankhwala.
• Tsiku ndi tsiku yang'anirani shuga m'magazi kuti pasapezeke kuchuluka.

Kugwiritsa ntchito monosaccharide mu shuga

Tasankha kale momwe monosaccharide yachiwiri imasiyanirana ndi glucose. Koma ndibwino kugwiritsa ntchito ngati chakudya, ndi zakudya ziti zomwe zimakhala ndi vuto la matenda ashuga?

Pali zinthu zomwe mu fructose ndi shuga zimakhala zofanana. Kwa anthu athanzi, tandem iyi ndi yabwino, popeza zinthu ziwiri izi zokha zimaphatikizidwa mwachangu, popanda kukhalabe m'thupi momwe amapangira mafuta. Kwa odwala matenda a shuga, kugwiritsa ntchito kwawo sikuloledwa. Zogulitsa zotere zimaphatikizapo zipatso zakupsa ndi zakudya zosiyanasiyana kuchokera kwa iwo, kuphatikizapo kusunga. Zakumwa zochokera m'masitolo ndizovomerezeka, chifukwa zimakhala ndi fructose ndi shuga nthawi yomweyo.

Anthu ambiri amafunsa kuti, "Kodi shuga kapena fructose amawonjezera zakumwa zotentha za matenda ashuga?" Yankho lake ndi losavuta: "Palibe chochokera pamwambapa!" Shuga ndi mawonekedwe ake omwe amapezekanso ndizovulaza. Yotsirizira mu mawonekedwe ake oyera ili ndi pafupifupi 45% sucrose, yokwanira kuvulaza mkhalidwe wodwala wodwala matenda a shuga.

Kugwiritsa ntchito Monosaccharide ndi Ana

Amayi nthawi zina amasankha: fructose kapena shuga amakhala othandiza kwa ana monga maswiti. Ndi chinthu chiti chomwe chiri bwino kusankha zinthu?

• Imakhala yosakanikirana bwino, ndikuchepetsa katundu pa zikondamoyo za mwana.
• Sizoyambitsa diathesis.
• Zimalepheretsa kuchulukana kwa tizilombo toyambitsa matenda mkamwa.
• Amapereka mphamvu zambiri.
• Ndi matenda 1 a shuga, mutha kuchepetsa mlingo wa insulin.

Koma muyenera kukumbukira kuti fructose kapena shuga adzagwiritsidwa ntchito, sangathe kuzunzidwa makamaka ali aang'ono kuti aletse kukula kwa matenda ashuga.

Glycated (glycosylated) hemoglobin. Kuyesa kwa magazi kwa hemoglobin ya glycated

Glycated (glycosylated) hemoglobin ndi gawo limodzi lathunthu la hemoglobin lomwe limazungulira m'magazi lomwe limapangidwa ndi glucose. Chizindikiro ichi chimayeza mu%. Mwazi wamagazi ochulukirapo, kuchuluka kwa hemoglobin amadzadulidwa. Uku ndikuyezetsa magazi kofunikira kwa anthu odwala matenda ashuga kapena amisala. Zimawonetsa bwino kuchuluka kwa shuga m'magazi atatu m'miyezi itatu yapitayo. Amakulolani kuti muzindikire matenda ashuga panthawi ndikuyamba kuthandizidwa. Kapenanso musimikizireni munthu ngati alibe matenda ashuga.

• Momwe mungakonzekere ndikuyezetsa magazi awa,
• Mitundu ya hemoglobin wa glycated - gome losavuta,
• Glycated hemoglobin mwa amayi apakati
• Zoyenera kuchita ngati zotsatira zake zikukwezedwa,
• Dziwani matenda am'mbuyomu, mtundu 1 ndi mtundu 2
• Kuwunika momwe chithandizo cha matenda ashuga chimayendera.

Mayina ena chizindikiro ichi:

• glycosylated hemoglobin,
• hemoglobin A1C,
• HbA1C,
• kapena A1C chabe.

Kuyesedwa kwa magazi kwa hemoglobin ya glycated ndi koyenera kwa odwala ndi madokotala. Ili ndiubwino wopindulitsa mayeso a shuga wamagazi ndi mayeso opitilira shuga a maola awiri. Izi ndi zabwino:

• kuwunika kwa hemoglobin wa glycated kumatha kuchitika nthawi iliyonse, osati pamimba yopanda kanthu,
• ndizolondola kuposa kuyesa kwa shuga m'magazi, kumakupatsani mwayi wofufuza matenda ashuga kale,
• ndiwofulumira komanso wosavuta kuposa mayeso a glucose a 2 maola,
• limakupatsani mwayi woyankha funso ngati munthu ali ndi matenda ashuga kapena ayi,
• Zimathandiza kudziwa kuti munthu wodwala matenda ashuga amawongolera bwanji shuga m'miyezi itatu yapitayo,
• hemoglobin wa glycated samakhudzidwa ndi mfundo zazifupi monga kuzizira kapena zinthu zovuta.

Upangiri wabwino: mukapita kukayezetsa magazi - nthawi yomweyo onani kuchuluka kwa hemoglobin HbA1C.

Zotsatira zakuwunika izi sizimadalira:

• nthawi yakupereka magazi,
• Amaipereka pamimba yopanda kanthu kapena itatha kudya,
• kumwa mankhwala kusiyapo mapiritsi a shuga,
• mkhalidwe wodwala
• chimfine ndi matenda ena.

Chifukwa chiyani kuyezetsa magazi kwa glycated hemoglobin

Choyamba, kuti mupeze matenda ashuga kapena kuwunika kuti munthu akhale ndi matenda ashuga. Kachiwiri, pofuna kuwunika ndi matenda ashuga momwe wodwalayo amatha kutsata matenda ndikusunga shuga pafupi ndi masiku abwinobwino.

Pozindikira matenda ashuga, chizindikirochi chakhala chikugwiritsidwa ntchito (pamalangizo a World Health Organisation) kuyambira 2011, ndipo chakhala chokwanira kwa odwala komanso madokotala.

Mitundu ya glycated hemoglobin

Kutsika kwa hemoglobin m'magazi, momwemo shuga yakeyo idalipidwa m'miyezi itatu yapitayo.

Makulidwe a HbA1C pa kuchuluka kwa shuga m'magazi atatu kwa miyezi itatu

• Momwe mungalandiridwire matenda a shuga a mtundu wachiwiri: njira imodzi ndi imodzi
• Mankhwala 2 a shuga: nkhani yatsatanetsatane
• Mapiritsi a Siofor ndi Glucofage
• Momwe mungaphunzirire kusangalala ndi maphunziro akuthupi

Kuyesedwa kwa magazi kwa hemoglobin ya glycated: zabwino ndi zovuta

Kuyesedwa kwa magazi kwa HbA1C, kuyerekeza ndi kusanthula shuga wosala kudya, kuli ndi maubwino angapo:

• munthu samayenera kukhala ndi mimba yopanda kanthu
• magazi amasungidwa mosavuta mu chubu choyeserera kufikira atasanthula posachedwa (preanalytical solid),
• kusala shuga wa plasma kumatha kusiyanasiyana chifukwa cha kupsinjika ndi matenda opatsirana, ndipo hemoglobin ya glycated imakhazikika

Kuyesedwa kwa magazi kwa hemoglobin ya glycated kumakupatsani mwayi woti muzindikire matenda ashuga kumayambiriro, pamene kupenda shuga kosala kudya kumasonyezabe kuti zonse zili bwino.

Zovuta zoyesa magazi a hemoglobin glycated:

• mtengo wokwera kwambiri poyerekeza ndi kuyesa kwa shuga m'magazi am'madzi (koma mwachangu komanso osavuta!),
• mwa anthu ena, kuphatikiza pakati pa HbA1C ndi kuchuluka kwa shuga kumachepa
• Odwala omwe ali ndi magazi m'thupi komanso hemoglobinopathies, amawunika amasintha,
• M'madera ena a dziko, odwala sangakhale ndi kochita kuyesa,
• zimaganiziridwa kuti ngati munthu atenga waukulu mavitamini C ndi / kapena E, ndiye kuti kuchuluka kwa hemoglobin ya glycated kumakhala kotsika mwachinyengo (sizinatsimikizidwe!),
• kuchepa kwa mahomoni a chithokomiro kungachititse kuti HbA1C iwonjezeke, koma magazi a magazi samachuluka.

Ngati muchepetsa HbA1C ndi 1%, kuchuluka kwa zovuta za matenda ashuga kuzachepa:

Glycated hemoglobin pa nthawi yapakati

Glycated hemoglobin pa nthawi yomwe ali ndi pakati ndi imodzi mwazomwe angathe kuyesa magazi a shuga. Komabe, uku ndikusankha koyipa. Pa nthawi yomwe muli ndi pakati, ndibwino kuti musapereke hemoglobin wa glycated, koma kuyang'ana shuga wamagazi ake m'njira zina. Tiyeni tifotokozere chifukwa chake zili choncho, ndikuyankhula pazina zolondola.

Kodi chiwopsezo chochuluka cha shuga mu amayi apakati ndi chiyani? Choyamba, chakuti mwana wosabadwayo amakula kwambiri, ndipo chifukwa cha izi padzakhala kubadwa kovuta. Kuopsa kwa mayi ndi mwana kumachuluka. Osanenapo zoyipa zazitali za onsewo. Kuchulukitsa kwa magazi panthawi yomwe ali ndi pakati kumawononga mitsempha yamagazi, impso, mawonekedwe amaso, ndi zina. Zotsatira za izi zikuwoneka pambuyo pake. Kukhala ndi mwana ndi theka nkhondo. Ndikofunikira kuti akhale ndi thanzi lokwanira kuti amulere ...

Mwazi wamagazi panthawi yokhala ndi pakati umatha kuchuluka ngakhale mwa azimayi omwe sanadandaulepo za thanzi lawo kale. Pali mbali ziwiri zofunika pano:

1. Shuga wapamwamba samayambitsa chilichonse. Nthawi zambiri mkazi samayikira chilichonse, ngakhale ali ndi chipatso chachikulu - chimphona cholemera makilogalamu 4-4,5.
2. Shuga samatuluka pamimba yopanda kanthu, koma akatha kudya. Atatha kudya, amakweza maola 1-4. Pakadali pano, akuchita ntchito yake yowononga. Kusala shuga nthawi zambiri. Ngati shuga amakwezedwa pamimba yopanda kanthu, ndiye kuti nkhaniyo ndiyabwino kwambiri.

Chifukwa chiyani kuyezetsa magazi kwa glycated hemoglobin sikulinso koyenera? Chifukwa samvera mochedwa. Glycated hemoglobin imangokulira pambuyo poti shuga m'magazi atakwezedwa kwa miyezi iwiri. Ngati mayi akweza shuga, ndiye kuti nthawi zambiri izi sizichitika kale kuposa mwezi wa 6 wamayi. Nthawi yomweyo, hemoglobin ya glycated idzachulukitsidwa pakangotha ​​miyezi 8-9, itatsala pang'ono kubereka. Ngati mayi woyembekezera samayang'anira shuga wake m'mbuyomu, ndiye kuti padzakhala zotsatirapo zoipa kwa iye ndi mwana wake.

Ngati glycated hemoglobin komanso kuyeza magazi kwa glucose sizoyenera, ndiye kuti mungayang'anire bwanji shuga kwa amayi apakati? Yankho: liyenera kufufuzidwa mukamadya pafupipafupi milungu iwiri iliyonse. Kuti muchite izi, mutha kuyesa mayeso a glucose a maola awiri mu labotale. Koma ichi ndi chochitika chachitali komanso chotopetsa. Ndiosavuta kugula mita yolowera m'magazi komanso kuyeza shuga 30, 60 ndi mphindi 120 mutatha kudya. Ngati zotsatira zake sizabwino kuposa 6.5 mmol / l - zabwino kwambiri. Muli mitundu 6.5-7.9 mmol / l - yolekerera. Kuchokera ku 8.0 mmol / L ndi kukwera - zoyipa, muyenera kuchitapo kanthu kuti muchepetse shuga.

Sungani chakudya chamagulu owonjezera, koma idyani zipatso, kaloti, ndi beets tsiku lililonse kuti muchepetse ketosis. Nthawi yomweyo, kukhala ndi pakati sikungakhale chifukwa chodzilola kuti mudye kwambiri ndi maswiti ndi mankhwala a ufa. Kuti mumve zambiri, onani nkhani za Pregnty Diabetes and Gestational Diabetes.

Zotsatira zoyipa Glidiab mv:

Kuchokera mmimba:

Kuchokera ku hemopoietic system: nthawi zina - thrombocytopenia, agranulocytosis kapena leukopenia, kuchepa magazi (nthawi zambiri kumatha kusintha).

Kuchokera endocrine dongosolo: ndi bongo - hypoglycemia.

Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa.

Zotsatira zamankhwala:

Insulin yodalira matenda a shuga a m'mellitus (mtundu I), ketoacidosis, matenda a shuga komanso chikomokere, matenda opweteka kwambiri aimpso ndi kwa chiwindi, hypersensitivity kuti sulfonylureas ndi sulfonamide kukonzekera. Kugwiritsa ntchito munthawi yomweyo gliclazide ndi imidazole zotumphukira (kuphatikizapo miconazole).

Malangizo apadera ogwiritsira ntchito Glidiab mv.

Gliclazide imagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe samatengera insulin kuphatikiza ndi zakudya zama calorie ochepa, zama carb ochepa.

Pa chithandizo, muyenera kuwunika kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, kusinthasintha kwa tsiku ndi tsiku m'magazi a shuga.

Pankhani ya chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, ndikofunikira kulingalira kuti mwina mungagwiritse ntchito insulin pokonzekera.

Ndi chitukuko cha hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena yankho la shuga) amapatsidwa mkati. Pofuna kutaya chikumbumtima, glucose wamitsempha kapena glucagon sc, intramuscularly kapena kudzera m'mitsempha amathandizira. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.

Pogwiritsa ntchito munthawi yomweyo gliclazide yokhala ndi verapamil, kuyang'anira kuchuluka kwa shuga m'magazi kumafunika, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa dongosolo lothandizira la hypoglycemic.

Kugwiritsa ntchito pamodzi gliclazide ndi cimetidine osavomerezeka.